Genomes and Genes
Summary: Signal molecules that are involved in the control of cell growth and differentiation.
Publications218 found, 100 shown here
- Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamilyE E Storm
Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427
Nature 368:639-43. 1994..The highly specific skeletal alterations in bp and short ear mice suggest that different members of the BMP family control the formation of different morphological features in the mammalian skeleton...
- WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumorsD Pennica
Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 95:14717-22. 1998..These results suggest that the WISP genes may be downstream of Wnt-1 signaling and that aberrant levels of WISP expression in colon cancer may play a role in colon tumorigenesis...
- Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancP N Nair
Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Oncogene 20:8203-14. 2001..This likely protects cells from unfavorable conditions and allows cells to rapidly re-enter the cell cycle when conditions are favorable...
- Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironmentsYoav Soen
Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
Mol Syst Biol 2:37. 2006....
- Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factorsSamuel Ebong
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Invest Ophthalmol Vis Sci 45:872-8. 2004....
- Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathwayA E Aplin
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Sci 112:695-706. 1999....
- Cyclooxygenase regulates angiogenesis induced by colon cancer cellsM Tsujii
Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
Cell 93:705-16. 1998..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
- Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cellsKan Ding
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
J Cell Biol 171:729-38. 2005..These results support a specific role for shed syndecan-1 or MMP7-syndecan-1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo...
- Trefoil peptides: from structure to functionL Thim
Department of Protein Chemistry, Novo Nordisk A S, Bagsvaerd, Denmark
Cell Mol Life Sci 53:888-903. 1997..This review summarises our present knowledge of trefoil peptide structures, their sites of expression, and their protection and repair functions, with a focus on the mechanism by which these peptides exert their biological function...
- Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb inductionX Xu
Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Development 125:753-65. 1998....
- Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene familyN M Wolfman
Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
J Clin Invest 100:321-30. 1997..In addition, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are important regulatory components of synovial joint morphogenesis...
- Upstream and downstream of mTORNissim Hay
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
Genes Dev 18:1926-45. 2004..We also summarize the roles of mTOR in the control of cell growth and proliferation, as well as its relevance to cancer and synaptic plasticity...
- The effect of discontinuing the use of antimicrobial growth promoters on the productivity in the Danish broiler productionH Emborg
Danish Veterinary Laboratory, Bulowsvej 27, DK 1790, Copenhagen V, Denmark
Prev Vet Med 50:53-70. 2001..However, the feed-conversion ratio increased marginally 0.016 kg/kg and has remained at this level throughout the rest of the study period...
- ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivoGieri Camenisch
Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 277:17281-90. 2002..Taken together, our data demonstrate that ANGPTL3 is the first member of the angiopoietin-like family of secreted factors binding to integrin alpha(v)beta(3) and suggest a possible role in the regulation of angiogenesis...
- WISP-1 is a Wnt-1- and beta-catenin-responsive oncogeneL Xu
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
Genes Dev 14:585-95. 2000..Although these cells did not acquire anchorage-independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1...
- Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversityS T Baur
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Development 127:605-19. 2000....
- Progranulin is a mediator of the wound responseZhiheng He
Division of Experimental Medicine, McGill University, and Endocrine Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada
Nat Med 9:225-9. 2003..It acts directly on isolated dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Progranulin is, therefore, a probable wound-related growth factor...
- A human chondrodysplasia due to a mutation in a TGF-beta superfamily memberJ T Thomas
Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 12:315-7. 1996..The resulting phenotype provides direct evidence for the involvement of CDMP-1 in human skeletal development and represents the first human disorder attributable to a mutation in a TGF-beta superfamily member...
- Tissue engineering for bone defect healing: an update on a multi-component approachInga Drosse
Department of Surgery, University of Munich, LMU, Munich, Germany
Injury 39:S9-20. 2008..With a strong focus on the preclinical research in this field, the goal of this review is to give an update on the multi-component approaches that are currently being investigated in tissue engineering of bone...
- Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combinationRobert I Nicholson
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff, Wales, United Kingdom
Clin Cancer Res 10:346S-54S. 2004....
- Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factorH Mashimo
Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Jackson 7, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
Science 274:262-5. 1996..ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa...
- Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selectionMelody Baddoo
Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Cell Biochem 89:1235-49. 2003..Therefore, FGF2 appears to function as a mitogen and self-maintenance factor for murine MSCs enriched from bone marrow by negative selection...
- Tumor-stroma interactions: their role in the control of tumor cell invasionP Zigrino
Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Joseph Stelzmann Strasse, 50931 Cologne, Germany
Biochimie 87:321-8. 2005..We shortly review the most important and well characterized mechanisms involved in the progression of tumor cells through tissues, especially those participating in cellular communication, cell adhesion, and proteolysis...
- Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic developmentK M Lyons
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
Genes Dev 3:1657-68. 1989..Our results suggest that the coordinated expression of several members of the TGF beta superfamily is required to control the progression of specific cell types through their differentiation pathways...
- GDF5 coordinates bone and joint formation during digit developmentE E Storm
Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University, Beckman Center B300, Palo Alto, California 94305 5329, USA
Dev Biol 209:11-27. 1999..Thus, GDF5 function in the digits demonstrates a link between cartilage development and joint development and is an important determinant of the pattern of bones and articulations in the digits...
- Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic miceL Aigner
Friedrich Miescher Institute, Basel, Switzerland
Cell 83:269-78. 1995..A mutant GAP-43 that cannot be phosphorylated by PKC had reduced sprout-promoting activity. The results establish GAP-43 as an intrinsic presynaptic determinant for neurite outgrowth and plasticity...
- Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrixBarbara Blum
Wright Medical Technology, Inc, Arlington, Tenn, USA
Orthopedics 27:s161-5. 2004..A strong association was noted between BMP-2 and TGF-beta1 levels. A strong association was also found between BMP-2 and new bone formation in an ectopic nude rat model...
- Factors stimulating bone formationM Lind
Orthopaedic Research Laboratory, University Hospital of Aarhus, Denmark
Eur Spine J 10:S102-9. 2001..Apart from bone transplantation, clinical experience with the many stimulation modalities is limited. Possible areas for clinical use of these novel methods are discussed...
- Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathwaysJiahu Wang
Department of Cell Biology, University of Virginia, Charlottesville, VA 22904, USA
J Cell Biol 174:689-700. 2006..Outward flow of lacritin from secretory cells through ducts may generate a proliferative/secretory field as a different unit of cellular renewal in nongermative epithelia where luminal structures predominate...
- Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cellsXinghui Tian
Stem Cell Institute and Dept of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Exp Hematol 32:1000-9. 2004..Here, we better characterize cell-bound and secreted factors that support this hematopoietic development...
- The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factorsL Bianchini
Centre de Biochimie, CNRS, Universite de Nice, France
J Biol Chem 272:271-9. 1997..In contrast, we found no evidence in favor of the contribution of any MAPK, p42/p44, p38 MAPKs, and Jun kinase, in NHE1 activation by osmotic stress...
- Novel strategies for tracing the exposure of meat cattle to illegal growth-promotersC Nebbia
Dipartimento di Patologia Animale, Sezione di Farmacologia e Tossicologia, Universita di Torino, Via Leonardo da Vinci 44, 10095 Grugliasco, Turin, Italy
Vet J 189:34-42. 2011..Further research is required before any potential biomarkers can be utilised for large scale high throughput screening tests...
- Maturational disturbance of chondrocytes in Cbfa1-deficient miceM Inada
Department of Medicine III, Osaka University Medical School, Japan
Dev Dyn 214:279-90. 1999..These findings demonstrate that Cbfa1 is an important factor for chondrocyte differentiation...
- Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced featuresD Xie
Division of Hematology Oncology, Cedars Sinai Medical Center, Department of Biomathematics, UCLA School of Medicine, Los Angeles, California 90048, USA
Cancer Res 61:8917-23. 2001..In summary, these results suggest that CTGF, WISP-1, and CYR61 may play a role in the progression of breast cancer and might serve as a valuable tool for monitoring tumor status of breast cancer patients...
- The development of androgen-independent prostate cancerB J Feldman
Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
Nat Rev Cancer 1:34-45. 2001....
- Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cellsN Ferrara
Department of Pharmacological Sciences, Genentech Inc, South San Francisco, CA 94080
Biochem Biophys Res Commun 161:851-8. 1989..Microsequencing reveals a unique N-terminal amino acid sequence. On the basis of its apparent target cell selectivity, we propose to name this factor vascular endothelial growth factor (VEGF)...
- X. Trefoil peptide and EGF receptor/ligand transgenic miceA S Giraud
Department of Medicine, University of Melbourne, Western Hospital, Footscray 3011, Australia
Am J Physiol Gastrointest Liver Physiol 278:G501-6. 2000..Future applications of transgenic technology to these areas are likely to be productive in furthering our understanding of the biology of these peptides in health and disease...
- All for one and one for all: condensations and the initiation of skeletal developmentB K Hall
Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
Bioessays 22:138-47. 2000..Growth of a condensation ceases when Noggin inhibits BMP signalling, setting the stage for transition to the next stage of skeletal development, namely overt cell differentiation. BioEssays 22:138-147, 2000...
- Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarrayM Rosario Hernandez
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
Glia 38:45-64. 2002....
- Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chainsA E Aplin
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 274:31223-8. 1999....
- WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinaseFei Su
Laboratory of Cancer Biology, The Rockefeller University, New York, New York 10021 6399, USA
Genes Dev 16:46-57. 2002..WISP-1 acts to block cell death at a late stage in the p53-mediated apoptosis pathway...
- Fibroblast growth factor interactions in the developing lungD Lebeche
Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
Mech Dev 86:125-36. 1999..Our data support a model in which Shh, TGFbeta-1 and BMP-4 counteract the bud promoting effects of FGF-10, and where FGF levels are maintained throughout lung development by other FGFs and Shh...
- BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear miceJ A King
Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427
Dev Biol 166:112-22. 1994..The combined genetic, biochemical, and expression data suggest that BMP5 is a key signal used to initiate formation of particular skeletal elements and is required for normal development of several soft tissues as well...
- Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptorsH Friess
Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland
J Mol Med (Berl) 74:35-42. 1996..These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection...
- The role of the IGF-I receptor in the growth and transformation of mammalian cellsR Baserga
Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cell Prolif 27:63-71. 1994..The picture emerging from these studies is that several transforming agents may exert their growth promoting effects through the direct or indirect activation of the IGF autocrine loop...
- Collision-induced dissociation of corticosteroids in electrospray tandem mass spectrometry and development of a screening method by high performance liquid chromatography/tandem mass spectrometryJ P Antignac
Laboratoire National de Référence LDH LNR, Ecole Nationale Veterinaire de Nantes, BP 50707, Nantes Cedex 3, France
Rapid Commun Mass Spectrom 14:33-9. 2000..The MRM method was then evaluated with the objective of use for the detection of corticosteroid residues in biological samples (urine, hair, muscle) and for a metabolism study...
- Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cellsY Hashimoto
Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104, Japan
J Exp Med 187:289-96. 1998..Metastatic potential of transfectants was reduced in proportion to the level of Elm1 expression. Thus, Elm1 is a novel gene of CCN family that can suppress the in vivo growth and metastatic potential of K-1735 mouse melanoma cells...
- Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1J T Thomas
Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 17:58-64. 1997..The mutation and its proposed mechanism of action provide the first human genetic indication that composite expression patterns of different BMPs dictate limb and digit morphogenesis...
- Expression profiling of skeletal muscle in young bulls treated with steroidal growth promotersL Carraro
Department of Public Health, Comparative Pathology, and Veterinary Hygiene, University of Padova, Legnaro PD, Italy
Physiol Genomics 38:138-48. 2009..g., cell shape and motility). Finally, the observed differences in the expression profile will allow the development of indirect bio-markers to detect illegal Dex treatments in beef cattle using quantitative RT-PCR...
- Study of dexamethasone urinary excretion profile in cattle by LC-MS/MS: comparison between therapeutic and growth-promoting administrationMarco Vincenti
Department of Animal Pathology, Division of Pharmacology and Toxicology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Torino, Italy
J Agric Food Chem 57:1299-306. 2009..Our findings confirm the high and rapid rate of dexamethasone urinary excretion irrespective of the nature of the treatment, and provide useful reference values that can be conveniently employed for forensic purposes...
- FGF-10 is a chemotactic factor for distal epithelial buds during lung developmentW Y Park
Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Dev Biol 201:125-34. 1998....
- Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouseC M Jones
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
Development 111:531-42. 1991..Together, the data support the hypothesis that polypeptide growth factors of the TGF-beta superfamily play key roles in the initial stages of neurogenesis and organogenesis during murine development...
- Patterning systems--from one end of the limb to the otherC Tickle
Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom
Dev Cell 4:449-58. 2003..This review describes current understanding of these regulatory mechanisms and how they form a framework for future analysis of limb patterning...
- IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injuryJ Corne
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
J Clin Invest 106:783-91. 2000..They also demonstrate that IL-13, alone and in combination with 100% (2), stimulates pulmonary VEGF accumulation, that this stimulation is isoform-specific, and that the protective effects of IL-13 are mediated, in part, by VEGF...
- Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signalingOksana V Tyurina
Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
Dev Biol 277:537-56. 2005..These results reveal a conserved role for Gli3 in vertebrate development and uncover novel regional functions and regulatory interactions among gli genes...
- Evaluation of indirect biomarkers for detecting corticosteroids used as illegal growth promoters in beef cattleM Vascellari
Department of Histopathology, Istituto Zooprofilattico Sperimentale delle Venzie, Via dell Università 10, 35020 Legnaro, Padova, Italy
Vet Rec 163:147-51. 2008..The samples that were positive by chemical analysis had cortisol concentrations of less than 2.0 ng/ml, whereas the mean cortisol concentration of the negative samples was 10.3 ng/ml...
- Protein expression changes in skeletal muscle in response to growth promoter abuse in beef cattleRoberto Stella
Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell Università 10, 35020 Legnaro, Italy
J Proteome Res 10:2744-57. 2011..As a further validation, we repeated the analysis using an independent set of samples from a strain of pure-bred cattle and verified these proteins by Western blot analysis...
- HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivoYuemeng Dai
Department of Pathology and the Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Biol Chem 280:40066-73. 2005..These findings demonstrate that dynamic regulation of heparan sulfate structure by Sulfs present within the tumor microenvironment can have a dramatic impact on the growth and progression of malignant cells in vivo...
- Investigating the effect of VEGF glycosylation on glycosaminoglycan binding and protein unfoldingBarbara Brandner
Institute of Pharmaceutical Sciences, University of Graz, A 8010 Graz, Austria
Biochem Biophys Res Commun 340:836-9. 2006..Unfolding studies of the VEGF proteins indicated a stabilising effect of heparin on the growth factor structure...
- Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor)R Lu
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 North Pine Street, Baltimore, MD 21201-1180, USA
Proc Natl Acad Sci U S A 98:142-7. 2001..We conclude that autocrine PCDGF mediates the E(2) mitogenic effect via stimulation of cyclin D1. These studies provide information on estrogen action and identify an autocrine molecular target in human breast cancer cells...
- The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) familyD R Brigstock
Department of Surgery, Ohio State University, Columbus 43210, USA
Endocr Rev 20:189-206. 1999
- Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytesC Ueta
Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
J Cell Biol 153:87-100. 2001..These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis, including formation of joints, permanent cartilages, and endochondral bones...
- Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cellsK Matsuda
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Biological Chemistry, and Pharmacology, University of California, Irvine, California 92697, USA
Cancer Res 61:5562-9. 2001....
- Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factorsS Rafii
Division of Vascular Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
Gene Ther 9:631-41. 2002..VEGF-mobilized endothelial and hematopoietic stem cells provide for an enriched source of adult pluripotent cells that can be used for revascularization, tissue regeneration or gene therapy...
- Induction of neuronal markers in bone marrow cells: differential effects of growth factors and patterns of intracellular expressionKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Exp Neurol 184:78-89. 2003....
- The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsA J Ridley
Institute for Cancer Research, Chester Beatty Laboratories, London, England
Cell 70:389-99. 1992..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
- CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domainT M Grzeszkiewicz
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
J Biol Chem 276:21943-50. 2001..Together, these findings establish CYR61 as a novel ligand for integrin alpha(v)beta(5) and show that CYR61 interacts with distinct integrins to mediate disparate activities in a cell type-specific manner...
- WISP3 is a novel tumor suppressor gene of inflammatory breast cancerCelina G Kleer
Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Oncogene 21:3172-80. 2002..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis...
- Heparanase regulates murine hair growthEyal Zcharia
Department of Oncology, Hadassah Hebrew University of Medical Center, Jerusalem, Israel
Am J Pathol 166:999-1008. 2005....
- Leptin is a growth factor in cancerPonnandai Somasundar
West Virginia University, Department of Surgery, PO Box 9238, Morgantown, West Virginia 26506, USA
J Surg Res 116:337-49. 2004
- Prospective cell sorting of embryonic rat neural stem cells and neuronal and glial progenitors reveals selective effects of basic fibroblast growth factor and epidermal growth factor on self-renewal and differentiationDragan Maric
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 23:240-51. 2003....
- Molecular prognostic markers in pancreatic cancerPaula Ghaneh
Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
J Hepatobiliary Pancreat Surg 9:1-11. 2002..Two studies (including our own) have found bcl-XL expression to be significantly associated with poor survival. These and newer molecular markers may prove to be important in the choice of future therapies for pancreatic cancer...
- Cyclooxygenase-independent actions of cyclooxygenase inhibitorsI Tegeder
Pharmazentrum Frankfurt, , Frankfurt, 60590 Frankfurt am Main, Germany
FASEB J 15:2057-72. 2001....
- Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acidsK Hayashi
Department of Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
Circ Res 89:251-8. 2001..Thus, this report demonstrates the first finding that unsaturated LPAs, but not saturated LPAs, specifically induce VSMC phenotypic modulation, suggesting that these molecules could function as atherogenic factors...
- Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epitheliumC D Donald
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Anticancer Res 21:3739-42. 2001..CONCLUSION: These data suggest that acrogranin may be a functional important growth factor in RCC and may be a potential molecular marker for high-grade RCC...
- Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of mSarama Sathyaseelan Deepa
Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
J Biol Chem 279:37368-76. 2004....
- Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissuesWai K Leung
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
J Pathol 197:582-8. 2002..Progressive loss of TFF1 and TFF2, together with the induction of TFF3, is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway...
- Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimersPascal Knuefermann
Winters Center for Heart Failure Research, Molecular Cardiology Unit, Cardiology Section of Department of Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, Texas 77030, USA
J Biol Chem 277:23888-97. 2002....
- Pancreatic cancer: factors regulating tumor development, maintenance and metastasisX Shi
Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland
Pancreatology 1:517-24. 2001..A complex disturbance of factors is present in pancreatic cancer, resulting in a distinct growth advantage which clinically results in rapid tumor progression and poor patient survival...
- Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginaseP G Cavanaugh
Institute for Molecular Medicine, Huntington Beach, California 92649, USA
Clin Exp Metastasis 18:509-18. 2000..The results indicate that certain liver-colonizing tumor cells can escape, to a degree, the proliferation-damping effects of arginine depletion...
- Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophySudhiranjan Gupta
Department of Molecular Cardiology NB 50, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA
Biochim Biophys Acta 1589:247-60. 2002..Our data provide evidence that myotrophin-kappaB DNA interaction may be an important step in initiating cardiac hypertrophy...
- Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cellsA Danilkovitch
Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, USA
Mol Cell Biol 20:2218-27. 2000..Growth factors induce MAPK activation, and adhesion mediates MAPK translocation from the cytoplasm into the nucleus...
- The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancerJ Kleeff
Departments of Medicine, Biological Chemistry, and Pharmacology, University of California, 92697, USA
J Clin Invest 102:1662-73. 1998....
- Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblastsD J Abraham
Center for Rheumatology, Royal Free and University College Medical School, Rowland Hill St, London W3 PF, United Kingdom
J Biol Chem 275:15220-5. 2000....
- Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structureK Miura
Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
Biochem Biophys Res Commun 187:375-80. 1992..The amino acid sequences of Nuc are highly conserved between mouse and human. We discuss the possible role of Nuc in autoimmunity...
- Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivoZ He
Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Cancer Res 59:3222-9. 1999....
- The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domainR Marais
Transcription Laboratory, Imperial Cancer Research Fund, London, England
Cell 73:381-93. 1993..These findings directly link transcriptional activation by the SRE to the growth factor-regulated phosphorylation of an SRE-binding protein...
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10D M Bradham
Department of Ophthalmology, University of South Florida College of Medicine, Tampa 33620
J Cell Biol 114:1285-94. 1991..The protein has a 45% overall homology to the translation product of the v-src-induced CEF-10 mRNA from chick embryo fibroblasts. We have termed this new mitogen connective tissue growth factor...
- The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident proteinP Lin
Division of Cellular and Molecular Medicine and Department of Pathology, University of California, San Diego, La Jolla, California 92093 0651, USA
J Cell Biol 141:1515-27. 1998..The properties of CALNUC and its high homology to calreticulin suggest that it may play a key role in calcium homeostasis in the CGN and cis-Golgi cisternae...
- Interaction of the protein nucleobindin with G alpha i2, as revealed by the yeast two-hybrid systemN Mochizuki
Department of Pharmacology, University of California San Diego, La Jolla 92093 0636, USA
FEBS Lett 373:155-8. 1995..Our results indicate that the yeast two-hybrid system provides a means to identify novel proteins that interact with G alpha proteins. Nucleobindin appears to represent one of those proteins...
- Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitroN Sivasubramanian
Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
J Biol Chem 271:2812-6. 1996..Thus, these results clearly indicate that the myotrophin protein to be a unique rel/NF-kappa B interacting protein...
- Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich proteinR P Ryseck
Bristol Myers Squibb Pharmaceutical Research Institute, Department of Molecular Biology, Princeton, New Jersey 08543
Cell Growth Differ 2:225-33. 1991..The fisp-12 gene maps to the [10A3-10B1] region of the murine genome...
- Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular developmentN W Gale
Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591 6707, USA
Genes Dev 13:1055-66. 1999
- Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrixA H Reddi
Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Matrix Biol 14:599-606. 1995..An avalanche of recent advances from seemingly disparate areas bodes well for the complete elucidation of the molecular basis of morphogenesis of cartilage, the architectural blue-print for the skeleton...
- Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) familyE E Storm
Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427, USA
Development 122:3969-79. 1996..This process helps determine the number of elements in repeating series in both limbs and sternum, and is required for normal generation of the functional articulations between many adjacent structures in the vertebrate skeleton...
- Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated proteinB A Ballif
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
Proc Natl Acad Sci U S A 93:5544-9. 1996..It also identifies Nuc as a potential regulator of COXs through this interaction...
- Myotrophin in human cardiomyopathic heartP Sil
Department of Cardiovascular Biology, Cleveland Clinic Foundation, OH 44195 5071
Circ Res 73:98-108. 1993....
- Global analysis of gene expression in renal ischemia-reperfusion in the mouseTakumi Yoshida
Renal Division, Department of Medicine, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
Biochem Biophys Res Commun 291:787-94. 2002..Our data identified several novel genes that may be important in renal repair after ischemia...
- Amphiregulin is a mitogen for adult neural stem cellsAnna Falk
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
J Neurosci Res 69:757-62. 2002....
- An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activityPaolo Michieli
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
Nat Biotechnol 20:488-95. 2002..In an in vivo murine model of drug-induced nephrotoxicity, intravenous injection of recombinant Metron factor 1 prevented renal damage and preserved tubular integrity...
- Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcomaShibani Pati
Institute of Human Virology, University of Maryland Biotechnology Institute, Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, USA
Blood 99:3771-9. 2002..Taken together, these data suggest that ritonavir has antineoplastic effects that are independent from its ability to inhibit the HIV protease...
- BREAST TUMOR PROXIMAL STROMA INTERACTION AND AROMATASESerdar Bulun; Fiscal Year: 2000..We will determine the effects of steroids and various growth substances on cytokine expression...
- ETS FACTOR NERF AND B CELL FUNCTIONJ Oettgen; Fiscal Year: 2000..proliferation of cells of the immune system often occur in response to external stimuli, such as antigens or growth substances. This response requires that the receptors on the surface of these cells recognize the stimulus and initiate ..
- EXPERIMENTAL ASBESTOS-INDUCED MESOTHELIOMAJOHN CRAIGHEAD; Fiscal Year: 1992..The outcome of these studies will support or refute the hypothesis that pro-growth substances stimulate their replication in the course of multistage carcinogenesis...
- Regulation of Wound Healing by Opioid Growth FactorRonald Wilson; Fiscal Year: 2005..It is now appreciated that a number of growth substances participate in the healing process to coordinate the interaction between the cells involved...
- ANGIOGENESIS, HEALING, AND AGING IN RETINA AND CHOROIDMichael Goldbaum; Fiscal Year: 1980..In the previous two years of the project, a technique of incorporating the growth substances in Elvax for slow release into adjacent tissue was developed...
- Tissue Engineering for the Treatment of Delayed HealingVincent Falanga; Fiscal Year: 2007..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
- Neonatal Stem Cells: Unique Traits in Paracine Signaling and CardioprotectionJEREMY HERRMANN; Fiscal Year: 2009..Understanding the ways that stem cells help patients will allow scientists to create "super" stem cells that both survive better in stressful conditions and release protective growth substances.
- PATHOGENIC MECHANISMS OF VENOUS DISEASEVincent Falanga; Fiscal Year: 2004..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
- MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDSVincent Falanga; Fiscal Year: 2003..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
- Lung epithelial and vascular morphogenesisDavid Warburton; Fiscal Year: 2006..abstract_text> ..
- Nanoparticle Targeting to Control AngiogenesisJEFFREY DAVIDSON; Fiscal Year: 2006..The objective is to design drug delivery systems that will specifically target pathological angiogenesis with minimal effects on the normal vasculature. ..
- ESTROGEN BIOTRANSFORMATIONS AND BREAST CANCER ETIOLOGYROBERT BRUEGGEMEIER; Fiscal Year: 2006..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
- NEUROENDOCRINE BASES OF REPRODUCTIVE BEHAVIORANNE ETGEN; Fiscal Year: 2006..Specific Aim 4 will determine how IGF-1 acutely potentiates a1-adrenoceptor signaling in the HYP-POA of E2-treated females and whether this is important for reproductive behavior. ..
- Angiogenesis in the Pulmonary MicrovasculatureDenis English; Fiscal Year: 2007..abstract_text> ..
- DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATIONDavid Warburton; Fiscal Year: 2010..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
- STEROID HORMONES--BRAIN AND BEHAVIORANNE ETGEN; Fiscal Year: 2007..These studies will provide novel[unreadable] insights into the cellular and molecular mechanisms by which ovarian[unreadable] sterioids act in the brain and to produce predictable behavioral[unreadable] changes. ..
- ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOLRichard Santen; Fiscal Year: 2008..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
- Human Hematopoietic Cell Transformation by BCR/ABLRavi Bhatia; Fiscal Year: 2008..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
- Abnormalities in gene expression in therapy-related MDSRavi Bhatia; Fiscal Year: 2008..These studies may also allow identification of markers of susceptibility to t-MDS allowing early detection of patients at risk for this complication. ..
- DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITYRichard Santen; Fiscal Year: 2009..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
- Estrogen: Neuroprotection in the PerimenopauseAnne M Etgen; Fiscal Year: 2010..These experiments will provide new information on the potential for hormone therapy instituted during the perimenopausal transition to protect the brain from damage due to global ischemia. ..
- Mechanism of Myocardial Angiogenesis in Transgenic/Knockout AnimalsNilanjana Maulik; Fiscal Year: 2010..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
- AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESISDavid Warburton; Fiscal Year: 2009..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
- Excess TGF beta in neonatal lung injury and repairDavid Warburton; Fiscal Year: 2004..abstract_text> ..
- MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATESDouglas Burrin; Fiscal Year: 2004....
- Hypoglycemia & exercise in children with type 1 diabetesPietro Galassetti; Fiscal Year: 2007..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..
- LIPOSOMAL BCL-2 ANTISENSE THERAPY FOR SOLID TUMORSFrancisco Esteva; Fiscal Year: 2003..Gabriel Lopez-Berestein (Department of Bioimmunotherapy). M. D. Anderson Cancer Center has the patients and resources necessary for Dr. Esteva to successfully complete this research project. ..
- Chemokine Blockade to Preserve Lung DevelopmentRichard Auten; Fiscal Year: 2005..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
- Akt, cellular senescence, and lifespanNissim Hay; Fiscal Year: 2010..abstract_text> ..
- The Role of IGF2 in Fetal Growth RestrictionPinchas Cohen; Fiscal Year: 2008..abstract_text> ..
- GDF Modulation of Tendon Maintenance and RepairBorjana Mikic; Fiscal Year: 2008..These studies combine to enhance our understanding of the mechanisms of action of GDFs in tendon maintenance and repair. ..
- NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENTSergio R Ojeda; Fiscal Year: 2010..4) To examine the hypothesis that a novel gene, termed EAP-1 (Enhanced At. Puberty-1) belongs - along with TTF-1 - to the hierarchy of controlling genes involved in the transcriptional regulation of the pubertal process. ..
- Thyroid Stimulating Hormone Promotes the Growth and Progression of Human MelanomaJulie Ellerhorst; Fiscal Year: 2008..Furthermore, melanoma cases may be prevented by heightened surveillance of individuals with a history of hypothyroidism. [unreadable] [unreadable] [unreadable]..
- ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIESJudith White; Fiscal Year: 2004..For example, the dual functions of ADAMs as both adhesion molecules and as proteases suggests that they may be key players in the de-adhesive, migratory, and re-adhesive activities involved in tumor metastasis. ..
- T cell homing in intestinal graft-versus-host diseaseMarcel van den Brink; Fiscal Year: 2009..These studies will contribute to a better mechanistic understanding of intestinal GVHD and provide preclinical data for new strategies to treat or prevent intestinal GVHD, while sparing GVT activity. ..
- LAMININ-8 AND LAMININ-10 IN SQUAMOUS CELL CARCINOMASJie Li; Fiscal Year: 2009....
- Axonal growth and guidance for nervous system repairGeorge Smith; Fiscal Year: 2009....
- Cyclin D1 and mammary carcinomaJ Diehl; Fiscal Year: 2009..The work proposed herein will establish the relationship between cyclin D1 nuclear retention and the function of cyclin D1 as an oncogenic protein in mammary carcinoma. ..
- REGULATION OF BONE REMODELING BY MEGAKARYOCYTESMark Horowitz; Fiscal Year: 2009..Such information would be applicable to a wide variety of skeletal defects including, post-menopausal osteoporosis, age-related osteopenia, fracture repair, and extended survival of prosthetic implants. ..
- REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTESRobert Olney; Fiscal Year: 2002..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
- GDF REGULATION OF ENDOCHONDRAL BONE GROWTHBorjana Mikic; Fiscal Year: 2002....
- Vein wall remodeling after DVT is matrix metalloproteinase dependentPeter Henke; Fiscal Year: 2009..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
- Mechanisms of Synovial Joint FormationMaurizio Pacifici; Fiscal Year: 2009..The results will be invaluable in conceiving novel, directed and specific therapies to repair and restore malfunctioning joints common to aging individuals and otherwise affected patients. ..
- 2003 FASEB Summer Conference on LysophospholipidsGabor Tigyi; Fiscal Year: 2003..The conference should provide a contemporary perspective of this rapidly moving field and allow the evaluation of future directions, as well as critical review of recent research. ..
- Lipotrope stimulates breast cancer cell deathChung Park; Fiscal Year: 2003..abstract_text> ..
- National Pharmacology Directors of Graduate Programs MeetingJoey Barnett; Fiscal Year: 2007..A continuing dialogue among Directors of training programs and other scientists with an interest in training is identified as a desired major outcome. [unreadable] [unreadable] [unreadable]..
- NEURONAL DEGENERATION: MECHANISMS AND PREVENTIONCAROL TROY; Fiscal Year: 2007..4. To determine how caspases-8 and -7 are activated after SOD1 down-regulation. 5. To determine if there is activation/regulation of caspase-3 and other caspases after SOD1 down-regulation. ..
- Mechanisms of MMP-3 Action in Acute Lung InjuryJames Varani; Fiscal Year: 2005..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
- Signaling Molecules and Long Bone FormationMaurizio Pacifici; Fiscal Year: 2005..The results will provide much needed information on the regulation of long bone formation, and will have relevance to questions of skeletal growth, fracture repair and congenital conditions of cartilage and bone. ..
- Inhibition of Migration for PVR TreatmentEugene Levin; Fiscal Year: 2005..Time course study to determine the minimum number of injections needed to inhibit PVR. These results will provide the basis for the eventual use of LD22-4 in the treatment of PVR. ..
- Xenoestrogens: Genomic and Non-genomic MechanismsNira Ben Jonathan; Fiscal Year: 2006..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
- Aging and the MicrovasculatureMay Reed; Fiscal Year: 2006..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
- Retinoic Acid Regulation of ErythropoiesisHenry Sucov; Fiscal Year: 2004..In this Aim, I will test the hypothesis that a transition occurs in definitive erythropoiesis from regulation of Epo gene expression retinoic acid and RXRalpha to regulation by HNF4. ..
- Conference: Biology of Calpains in Health and DiseaseNEIL FORSBERG; Fiscal Year: 2004..The proposed program will provide the forum by which the momentum in this field may be maintained. ..
- Identification of circadian clock output genesMark Drapeau; Fiscal Year: 2006..Then, some of these genes will be studied molecularly to determine how they are regulated by the central clock. ..
- IC Communication in Breast Cancer Metastasis to BoneHenry Donahue; Fiscal Year: 2005..The results of this project will provide insights into the mechanism by which breast cancer cells preferentially metastasize to bone, an important step in developing approaches to inhibit bone metastasis. ..
- A Novel Gene Network Controlling Mammalian PubertySergio Ojeda; Fiscal Year: 2006..Although siRNAs are widely used to perturb gene expression in mammalian cells, the methodology to achieve long-term silencing effects in vivo is still in its infancy. [unreadable] [unreadable]..
- BIOGENESIS AND FUNCTION OF CONNECTIVE TISSUE PROTEINSPaul Bornstein; Fiscal Year: 2004..It is anticipated that some of the mutations created in mice will generate useful models for human disorders of these tissues, specifically some of the Ehlers-Danlos syndromes and osteoporosis. ..
- A Request for support of 25th SPRSM MeetingJames Wang; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- PATHWAY OF VENTRICULAR MORPHOGENESIS MEDICATED BY RXRAHenry Sucov; Fiscal Year: 2001..abstract_text> ..
- Preventing choroidal neovascularization by long-term transscleral drug deliveryPURAN BORA; Fiscal Year: 2006..For proof-of-concept, we will use a novel, human protein-based therapy that has shown great potential in preliminary animal studies. [unreadable] [unreadable] [unreadable] [unreadable]..
- STUDY OF REG RECEPTOR-LIGAND BIOLOGY IN GI MUCOSABrian Dieckgraefe; Fiscal Year: 2008..These studies will also provide new insight into the role of Reg IV antagonists and lay the groundwork for development of therapeutic reagents active in gastrointestinal adenocarcinomas. ..
- Near Infra Red Energy To Treat Diabetic NeuropathyNIGEL CALCUTT; Fiscal Year: 2006..abstract_text> ..
- Local Angiogenic Gene Therapy/VEGF/Treat Diabetic UlcersHarold Brem; Fiscal Year: 2003..In addition, we will analyze the wound fluid in order to determine the temporal expression of VEGF in a diabetic ulcer. ..
- THE ROLE OF THE SIGNAL TRANSDUCERS IN TUMORIGENESISCorinne Silva; Fiscal Year: 2004..The ultimate goal is that these studies will lead to the identification of novel therapeutic methods and/or reagents for treating breast cancer. ..
- AASK NIH Cohort StudyJoel Kopple; Fiscal Year: 2007..Such results might eventually lead to new strategies that delay or prevent ESRD__ ..
- ALS-mutant SOD1-induced motor neuron apoptosisAlvaro Estevez; Fiscal Year: 2006....
- Testicular Torsion: Mechanisms and TreatmentTerry Turner; Fiscal Year: 2005..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
- Local Angiogenic Therapy for Diabetic UlcersHarold Brem; Fiscal Year: 2006..Support from this proposal will allow the applicant to use knowledge from the fields of gene therapy, angiogenesis and wound healing to develop a safe angiogenic gene therapy for diabetic foot ulcers. ..