growth substances

Summary

Summary: Signal molecules that are involved in the control of cell growth and differentiation.

Top Publications

  1. ncbi Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
    E E Storm
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427
    Nature 368:639-43. 1994
  2. pmc WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors
    D Pennica
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 95:14717-22. 1998
  3. ncbi Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the panc
    P N Nair
    Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Oncogene 20:8203-14. 2001
  4. pmc Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments
    Yoav Soen
    Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Mol Syst Biol 2:37. 2006
  5. ncbi Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors
    Samuel Ebong
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:872-8. 2004
  6. ncbi Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
    A E Aplin
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 112:695-706. 1999
  7. ncbi Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
  8. pmc Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    Kan Ding
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
    J Cell Biol 171:729-38. 2005
  9. ncbi Trefoil peptides: from structure to function
    L Thim
    Department of Protein Chemistry, Novo Nordisk A S, Bagsvaerd, Denmark
    Cell Mol Life Sci 53:888-903. 1997
  10. ncbi Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
    X Xu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 125:753-65. 1998

Research Grants

Detail Information

Publications218 found, 100 shown here

  1. ncbi Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
    E E Storm
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427
    Nature 368:639-43. 1994
    ..The highly specific skeletal alterations in bp and short ear mice suggest that different members of the BMP family control the formation of different morphological features in the mammalian skeleton...
  2. pmc WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors
    D Pennica
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 95:14717-22. 1998
    ..These results suggest that the WISP genes may be downstream of Wnt-1 signaling and that aberrant levels of WISP expression in colon cancer may play a role in colon tumorigenesis...
  3. ncbi Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the panc
    P N Nair
    Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Oncogene 20:8203-14. 2001
    ..This likely protects cells from unfavorable conditions and allows cells to rapidly re-enter the cell cycle when conditions are favorable...
  4. pmc Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments
    Yoav Soen
    Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Mol Syst Biol 2:37. 2006
    ....
  5. ncbi Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors
    Samuel Ebong
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:872-8. 2004
    ....
  6. ncbi Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
    A E Aplin
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 112:695-706. 1999
    ....
  7. ncbi Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
  8. pmc Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    Kan Ding
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
    J Cell Biol 171:729-38. 2005
    ..These results support a specific role for shed syndecan-1 or MMP7-syndecan-1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo...
  9. ncbi Trefoil peptides: from structure to function
    L Thim
    Department of Protein Chemistry, Novo Nordisk A S, Bagsvaerd, Denmark
    Cell Mol Life Sci 53:888-903. 1997
    ..This review summarises our present knowledge of trefoil peptide structures, their sites of expression, and their protection and repair functions, with a focus on the mechanism by which these peptides exert their biological function...
  10. ncbi Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
    X Xu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 125:753-65. 1998
    ....
  11. pmc Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family
    N M Wolfman
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    J Clin Invest 100:321-30. 1997
    ..In addition, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are important regulatory components of synovial joint morphogenesis...
  12. ncbi Upstream and downstream of mTOR
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    Genes Dev 18:1926-45. 2004
    ..We also summarize the roles of mTOR in the control of cell growth and proliferation, as well as its relevance to cancer and synaptic plasticity...
  13. ncbi The effect of discontinuing the use of antimicrobial growth promoters on the productivity in the Danish broiler production
    H Emborg
    Danish Veterinary Laboratory, Bulowsvej 27, DK 1790, Copenhagen V, Denmark
    Prev Vet Med 50:53-70. 2001
    ..However, the feed-conversion ratio increased marginally 0.016 kg/kg and has remained at this level throughout the rest of the study period...
  14. ncbi ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo
    Gieri Camenisch
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:17281-90. 2002
    ..Taken together, our data demonstrate that ANGPTL3 is the first member of the angiopoietin-like family of secreted factors binding to integrin alpha(v)beta(3) and suggest a possible role in the regulation of angiogenesis...
  15. pmc WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene
    L Xu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 14:585-95. 2000
    ..Although these cells did not acquire anchorage-independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1...
  16. ncbi Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity
    S T Baur
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 127:605-19. 2000
    ....
  17. ncbi Progranulin is a mediator of the wound response
    Zhiheng He
    Division of Experimental Medicine, McGill University, and Endocrine Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada
    Nat Med 9:225-9. 2003
    ..It acts directly on isolated dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Progranulin is, therefore, a probable wound-related growth factor...
  18. ncbi A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
    J T Thomas
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:315-7. 1996
    ..The resulting phenotype provides direct evidence for the involvement of CDMP-1 in human skeletal development and represents the first human disorder attributable to a mutation in a TGF-beta superfamily member...
  19. ncbi Tissue engineering for bone defect healing: an update on a multi-component approach
    Inga Drosse
    Department of Surgery, University of Munich, LMU, Munich, Germany
    Injury 39:S9-20. 2008
    ..With a strong focus on the preclinical research in this field, the goal of this review is to give an update on the multi-component approaches that are currently being investigated in tissue engineering of bone...
  20. ncbi Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination
    Robert I Nicholson
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff, Wales, United Kingdom
    Clin Cancer Res 10:346S-54S. 2004
    ....
  21. ncbi Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
    H Mashimo
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Jackson 7, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Science 274:262-5. 1996
    ..ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa...
  22. ncbi Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection
    Melody Baddoo
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cell Biochem 89:1235-49. 2003
    ..Therefore, FGF2 appears to function as a mitogen and self-maintenance factor for murine MSCs enriched from bone marrow by negative selection...
  23. ncbi Tumor-stroma interactions: their role in the control of tumor cell invasion
    P Zigrino
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Joseph Stelzmann Strasse, 50931 Cologne, Germany
    Biochimie 87:321-8. 2005
    ..We shortly review the most important and well characterized mechanisms involved in the progression of tumor cells through tissues, especially those participating in cellular communication, cell adhesion, and proteolysis...
  24. ncbi Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development
    K M Lyons
    Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
    Genes Dev 3:1657-68. 1989
    ..Our results suggest that the coordinated expression of several members of the TGF beta superfamily is required to control the progression of specific cell types through their differentiation pathways...
  25. ncbi GDF5 coordinates bone and joint formation during digit development
    E E Storm
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University, Beckman Center B300, Palo Alto, California 94305 5329, USA
    Dev Biol 209:11-27. 1999
    ..Thus, GDF5 function in the digits demonstrates a link between cartilage development and joint development and is an important determinant of the pattern of bones and articulations in the digits...
  26. ncbi Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
    L Aigner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 83:269-78. 1995
    ..A mutant GAP-43 that cannot be phosphorylated by PKC had reduced sprout-promoting activity. The results establish GAP-43 as an intrinsic presynaptic determinant for neurite outgrowth and plasticity...
  27. ncbi Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix
    Barbara Blum
    Wright Medical Technology, Inc, Arlington, Tenn, USA
    Orthopedics 27:s161-5. 2004
    ..A strong association was noted between BMP-2 and TGF-beta1 levels. A strong association was also found between BMP-2 and new bone formation in an ectopic nude rat model...
  28. pmc Factors stimulating bone formation
    M Lind
    Orthopaedic Research Laboratory, University Hospital of Aarhus, Denmark
    Eur Spine J 10:S102-9. 2001
    ..Apart from bone transplantation, clinical experience with the many stimulation modalities is limited. Possible areas for clinical use of these novel methods are discussed...
  29. pmc Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways
    Jiahu Wang
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22904, USA
    J Cell Biol 174:689-700. 2006
    ..Outward flow of lacritin from secretory cells through ducts may generate a proliferative/secretory field as a different unit of cellular renewal in nongermative epithelia where luminal structures predominate...
  30. ncbi Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells
    Xinghui Tian
    Stem Cell Institute and Dept of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Hematol 32:1000-9. 2004
    ..Here, we better characterize cell-bound and secreted factors that support this hematopoietic development...
  31. ncbi The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors
    L Bianchini
    Centre de Biochimie, CNRS, Universite de Nice, France
    J Biol Chem 272:271-9. 1997
    ..In contrast, we found no evidence in favor of the contribution of any MAPK, p42/p44, p38 MAPKs, and Jun kinase, in NHE1 activation by osmotic stress...
  32. ncbi Novel strategies for tracing the exposure of meat cattle to illegal growth-promoters
    C Nebbia
    Dipartimento di Patologia Animale, Sezione di Farmacologia e Tossicologia, Universita di Torino, Via Leonardo da Vinci 44, 10095 Grugliasco, Turin, Italy
    Vet J 189:34-42. 2011
    ..Further research is required before any potential biomarkers can be utilised for large scale high throughput screening tests...
  33. ncbi Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    M Inada
    Department of Medicine III, Osaka University Medical School, Japan
    Dev Dyn 214:279-90. 1999
    ..These findings demonstrate that Cbfa1 is an important factor for chondrocyte differentiation...
  34. ncbi Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features
    D Xie
    Division of Hematology Oncology, Cedars Sinai Medical Center, Department of Biomathematics, UCLA School of Medicine, Los Angeles, California 90048, USA
    Cancer Res 61:8917-23. 2001
    ..In summary, these results suggest that CTGF, WISP-1, and CYR61 may play a role in the progression of breast cancer and might serve as a valuable tool for monitoring tumor status of breast cancer patients...
  35. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
    ....
  36. ncbi Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    N Ferrara
    Department of Pharmacological Sciences, Genentech Inc, South San Francisco, CA 94080
    Biochem Biophys Res Commun 161:851-8. 1989
    ..Microsequencing reveals a unique N-terminal amino acid sequence. On the basis of its apparent target cell selectivity, we propose to name this factor vascular endothelial growth factor (VEGF)...
  37. ncbi X. Trefoil peptide and EGF receptor/ligand transgenic mice
    A S Giraud
    Department of Medicine, University of Melbourne, Western Hospital, Footscray 3011, Australia
    Am J Physiol Gastrointest Liver Physiol 278:G501-6. 2000
    ..Future applications of transgenic technology to these areas are likely to be productive in furthering our understanding of the biology of these peptides in health and disease...
  38. ncbi All for one and one for all: condensations and the initiation of skeletal development
    B K Hall
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Bioessays 22:138-47. 2000
    ..Growth of a condensation ceases when Noggin inhibits BMP signalling, setting the stage for transition to the next stage of skeletal development, namely overt cell differentiation. BioEssays 22:138-147, 2000...
  39. ncbi Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray
    M Rosario Hernandez
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Glia 38:45-64. 2002
    ....
  40. ncbi Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains
    A E Aplin
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:31223-8. 1999
    ....
  41. pmc WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase
    Fei Su
    Laboratory of Cancer Biology, The Rockefeller University, New York, New York 10021 6399, USA
    Genes Dev 16:46-57. 2002
    ..WISP-1 acts to block cell death at a late stage in the p53-mediated apoptosis pathway...
  42. ncbi Fibroblast growth factor interactions in the developing lung
    D Lebeche
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
    Mech Dev 86:125-36. 1999
    ..Our data support a model in which Shh, TGFbeta-1 and BMP-4 counteract the bud promoting effects of FGF-10, and where FGF levels are maintained throughout lung development by other FGFs and Shh...
  43. ncbi BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice
    J A King
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427
    Dev Biol 166:112-22. 1994
    ..The combined genetic, biochemical, and expression data suggest that BMP5 is a key signal used to initiate formation of particular skeletal elements and is required for normal development of several soft tissues as well...
  44. ncbi Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors
    H Friess
    Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland
    J Mol Med (Berl) 74:35-42. 1996
    ..These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection...
  45. ncbi The role of the IGF-I receptor in the growth and transformation of mammalian cells
    R Baserga
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Prolif 27:63-71. 1994
    ..The picture emerging from these studies is that several transforming agents may exert their growth promoting effects through the direct or indirect activation of the IGF autocrine loop...
  46. ncbi Collision-induced dissociation of corticosteroids in electrospray tandem mass spectrometry and development of a screening method by high performance liquid chromatography/tandem mass spectrometry
    J P Antignac
    Laboratoire National de Référence LDH LNR, Ecole Nationale Veterinaire de Nantes, BP 50707, Nantes Cedex 3, France
    Rapid Commun Mass Spectrom 14:33-9. 2000
    ..The MRM method was then evaluated with the objective of use for the detection of corticosteroid residues in biological samples (urine, hair, muscle) and for a metabolism study...
  47. pmc Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells
    Y Hashimoto
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104, Japan
    J Exp Med 187:289-96. 1998
    ..Metastatic potential of transfectants was reduced in proportion to the level of Elm1 expression. Thus, Elm1 is a novel gene of CCN family that can suppress the in vivo growth and metastatic potential of K-1735 mouse melanoma cells...
  48. ncbi Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
    J T Thomas
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 17:58-64. 1997
    ..The mutation and its proposed mechanism of action provide the first human genetic indication that composite expression patterns of different BMPs dictate limb and digit morphogenesis...
  49. ncbi Expression profiling of skeletal muscle in young bulls treated with steroidal growth promoters
    L Carraro
    Department of Public Health, Comparative Pathology, and Veterinary Hygiene, University of Padova, Legnaro PD, Italy
    Physiol Genomics 38:138-48. 2009
    ..g., cell shape and motility). Finally, the observed differences in the expression profile will allow the development of indirect bio-markers to detect illegal Dex treatments in beef cattle using quantitative RT-PCR...
  50. ncbi Study of dexamethasone urinary excretion profile in cattle by LC-MS/MS: comparison between therapeutic and growth-promoting administration
    Marco Vincenti
    Department of Animal Pathology, Division of Pharmacology and Toxicology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Torino, Italy
    J Agric Food Chem 57:1299-306. 2009
    ..Our findings confirm the high and rapid rate of dexamethasone urinary excretion irrespective of the nature of the treatment, and provide useful reference values that can be conveniently employed for forensic purposes...
  51. ncbi FGF-10 is a chemotactic factor for distal epithelial buds during lung development
    W Y Park
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Dev Biol 201:125-34. 1998
    ....
  52. ncbi Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse
    C M Jones
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
    Development 111:531-42. 1991
    ..Together, the data support the hypothesis that polypeptide growth factors of the TGF-beta superfamily play key roles in the initial stages of neurogenesis and organogenesis during murine development...
  53. ncbi Patterning systems--from one end of the limb to the other
    C Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom
    Dev Cell 4:449-58. 2003
    ..This review describes current understanding of these regulatory mechanisms and how they form a framework for future analysis of limb patterning...
  54. pmc IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
    J Corne
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 106:783-91. 2000
    ..They also demonstrate that IL-13, alone and in combination with 100% (2), stimulates pulmonary VEGF accumulation, that this stimulation is isoform-specific, and that the protective effects of IL-13 are mediated, in part, by VEGF...
  55. ncbi Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
    Oksana V Tyurina
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Dev Biol 277:537-56. 2005
    ..These results reveal a conserved role for Gli3 in vertebrate development and uncover novel regional functions and regulatory interactions among gli genes...
  56. ncbi Evaluation of indirect biomarkers for detecting corticosteroids used as illegal growth promoters in beef cattle
    M Vascellari
    Department of Histopathology, Istituto Zooprofilattico Sperimentale delle Venzie, Via dell Università 10, 35020 Legnaro, Padova, Italy
    Vet Rec 163:147-51. 2008
    ..The samples that were positive by chemical analysis had cortisol concentrations of less than 2.0 ng/ml, whereas the mean cortisol concentration of the negative samples was 10.3 ng/ml...
  57. ncbi Protein expression changes in skeletal muscle in response to growth promoter abuse in beef cattle
    Roberto Stella
    Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell Università 10, 35020 Legnaro, Italy
    J Proteome Res 10:2744-57. 2011
    ..As a further validation, we repeated the analysis using an independent set of samples from a strain of pure-bred cattle and verified these proteins by Western blot analysis...
  58. ncbi HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo
    Yuemeng Dai
    Department of Pathology and the Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:40066-73. 2005
    ..These findings demonstrate that dynamic regulation of heparan sulfate structure by Sulfs present within the tumor microenvironment can have a dramatic impact on the growth and progression of malignant cells in vivo...
  59. ncbi Investigating the effect of VEGF glycosylation on glycosaminoglycan binding and protein unfolding
    Barbara Brandner
    Institute of Pharmaceutical Sciences, University of Graz, A 8010 Graz, Austria
    Biochem Biophys Res Commun 340:836-9. 2006
    ..Unfolding studies of the VEGF proteins indicated a stabilising effect of heparin on the growth factor structure...
  60. pmc Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor)
    R Lu
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 North Pine Street, Baltimore, MD 21201-1180, USA
    Proc Natl Acad Sci U S A 98:142-7. 2001
    ..We conclude that autocrine PCDGF mediates the E(2) mitogenic effect via stimulation of cyclin D1. These studies provide information on estrogen action and identify an autocrine molecular target in human breast cancer cells...
  61. ncbi The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
    D R Brigstock
    Department of Surgery, Ohio State University, Columbus 43210, USA
    Endocr Rev 20:189-206. 1999
  62. pmc Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
    C Ueta
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 153:87-100. 2001
    ..These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis, including formation of joints, permanent cartilages, and endochondral bones...
  63. ncbi Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells
    K Matsuda
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Biological Chemistry, and Pharmacology, University of California, Irvine, California 92697, USA
    Cancer Res 61:5562-9. 2001
    ....
  64. ncbi Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors
    S Rafii
    Division of Vascular Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Gene Ther 9:631-41. 2002
    ..VEGF-mobilized endothelial and hematopoietic stem cells provide for an enriched source of adult pluripotent cells that can be used for revascularization, tissue regeneration or gene therapy...
  65. ncbi Induction of neuronal markers in bone marrow cells: differential effects of growth factors and patterns of intracellular expression
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Exp Neurol 184:78-89. 2003
    ....
  66. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
  67. ncbi CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain
    T M Grzeszkiewicz
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    J Biol Chem 276:21943-50. 2001
    ..Together, these findings establish CYR61 as a novel ligand for integrin alpha(v)beta(5) and show that CYR61 interacts with distinct integrins to mediate disparate activities in a cell type-specific manner...
  68. ncbi WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Oncogene 21:3172-80. 2002
    ..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis...
  69. pmc Heparanase regulates murine hair growth
    Eyal Zcharia
    Department of Oncology, Hadassah Hebrew University of Medical Center, Jerusalem, Israel
    Am J Pathol 166:999-1008. 2005
    ....
  70. ncbi Leptin is a growth factor in cancer
    Ponnandai Somasundar
    West Virginia University, Department of Surgery, PO Box 9238, Morgantown, West Virginia 26506, USA
    J Surg Res 116:337-49. 2004
  71. ncbi Prospective cell sorting of embryonic rat neural stem cells and neuronal and glial progenitors reveals selective effects of basic fibroblast growth factor and epidermal growth factor on self-renewal and differentiation
    Dragan Maric
    Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 23:240-51. 2003
    ....
  72. ncbi Molecular prognostic markers in pancreatic cancer
    Paula Ghaneh
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    J Hepatobiliary Pancreat Surg 9:1-11. 2002
    ..Two studies (including our own) have found bcl-XL expression to be significantly associated with poor survival. These and newer molecular markers may prove to be important in the choice of future therapies for pancreatic cancer...
  73. ncbi Cyclooxygenase-independent actions of cyclooxygenase inhibitors
    I Tegeder
    Pharmazentrum Frankfurt, , Frankfurt, 60590 Frankfurt am Main, Germany
    FASEB J 15:2057-72. 2001
    ....
  74. ncbi Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids
    K Hayashi
    Department of Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
    Circ Res 89:251-8. 2001
    ..Thus, this report demonstrates the first finding that unsaturated LPAs, but not saturated LPAs, specifically induce VSMC phenotypic modulation, suggesting that these molecules could function as atherogenic factors...
  75. ncbi Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium
    C D Donald
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Anticancer Res 21:3739-42. 2001
    ..CONCLUSION: These data suggest that acrogranin may be a functional important growth factor in RCC and may be a potential molecular marker for high-grade RCC...
  76. ncbi Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of m
    Sarama Sathyaseelan Deepa
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 279:37368-76. 2004
    ....
  77. ncbi Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Pathol 197:582-8. 2002
    ..Progressive loss of TFF1 and TFF2, together with the induction of TFF3, is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway...
  78. ncbi Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers
    Pascal Knuefermann
    Winters Center for Heart Failure Research, Molecular Cardiology Unit, Cardiology Section of Department of Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Biol Chem 277:23888-97. 2002
    ....
  79. ncbi Pancreatic cancer: factors regulating tumor development, maintenance and metastasis
    X Shi
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland
    Pancreatology 1:517-24. 2001
    ..A complex disturbance of factors is present in pancreatic cancer, resulting in a distinct growth advantage which clinically results in rapid tumor progression and poor patient survival...
  80. ncbi Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase
    P G Cavanaugh
    Institute for Molecular Medicine, Huntington Beach, California 92649, USA
    Clin Exp Metastasis 18:509-18. 2000
    ..The results indicate that certain liver-colonizing tumor cells can escape, to a degree, the proliferation-damping effects of arginine depletion...
  81. ncbi Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy
    Sudhiranjan Gupta
    Department of Molecular Cardiology NB 50, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA
    Biochim Biophys Acta 1589:247-60. 2002
    ..Our data provide evidence that myotrophin-kappaB DNA interaction may be an important step in initiating cardiac hypertrophy...
  82. pmc Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells
    A Danilkovitch
    Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, Maryland, USA
    Mol Cell Biol 20:2218-27. 2000
    ..Growth factors induce MAPK activation, and adhesion mediates MAPK translocation from the cytoplasm into the nucleus...
  83. pmc The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer
    J Kleeff
    Departments of Medicine, Biological Chemistry, and Pharmacology, University of California, 92697, USA
    J Clin Invest 102:1662-73. 1998
    ....
  84. ncbi Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts
    D J Abraham
    Center for Rheumatology, Royal Free and University College Medical School, Rowland Hill St, London W3 PF, United Kingdom
    J Biol Chem 275:15220-5. 2000
    ....
  85. ncbi Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure
    K Miura
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Biochem Biophys Res Commun 187:375-80. 1992
    ..The amino acid sequences of Nuc are highly conserved between mouse and human. We discuss the possible role of Nuc in autoimmunity...
  86. ncbi Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo
    Z He
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Cancer Res 59:3222-9. 1999
    ....
  87. ncbi The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
    R Marais
    Transcription Laboratory, Imperial Cancer Research Fund, London, England
    Cell 73:381-93. 1993
    ..These findings directly link transcriptional activation by the SRE to the growth factor-regulated phosphorylation of an SRE-binding protein...
  88. pmc Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
    D M Bradham
    Department of Ophthalmology, University of South Florida College of Medicine, Tampa 33620
    J Cell Biol 114:1285-94. 1991
    ..The protein has a 45% overall homology to the translation product of the v-src-induced CEF-10 mRNA from chick embryo fibroblasts. We have termed this new mitogen connective tissue growth factor...
  89. pmc The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein
    P Lin
    Division of Cellular and Molecular Medicine and Department of Pathology, University of California, San Diego, La Jolla, California 92093 0651, USA
    J Cell Biol 141:1515-27. 1998
    ..The properties of CALNUC and its high homology to calreticulin suggest that it may play a key role in calcium homeostasis in the CGN and cis-Golgi cisternae...
  90. ncbi Interaction of the protein nucleobindin with G alpha i2, as revealed by the yeast two-hybrid system
    N Mochizuki
    Department of Pharmacology, University of California San Diego, La Jolla 92093 0636, USA
    FEBS Lett 373:155-8. 1995
    ..Our results indicate that the yeast two-hybrid system provides a means to identify novel proteins that interact with G alpha proteins. Nucleobindin appears to represent one of those proteins...
  91. ncbi Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro
    N Sivasubramanian
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 271:2812-6. 1996
    ..Thus, these results clearly indicate that the myotrophin protein to be a unique rel/NF-kappa B interacting protein...
  92. ncbi Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein
    R P Ryseck
    Bristol Myers Squibb Pharmaceutical Research Institute, Department of Molecular Biology, Princeton, New Jersey 08543
    Cell Growth Differ 2:225-33. 1991
    ..The fisp-12 gene maps to the [10A3-10B1] region of the murine genome...
  93. ncbi Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
    N W Gale
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591 6707, USA
    Genes Dev 13:1055-66. 1999
  94. ncbi Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix
    A H Reddi
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Matrix Biol 14:599-606. 1995
    ..An avalanche of recent advances from seemingly disparate areas bodes well for the complete elucidation of the molecular basis of morphogenesis of cartilage, the architectural blue-print for the skeleton...
  95. ncbi Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
    E E Storm
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427, USA
    Development 122:3969-79. 1996
    ..This process helps determine the number of elements in repeating series in both limbs and sternum, and is required for normal generation of the functional articulations between many adjacent structures in the vertebrate skeleton...
  96. pmc Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein
    B A Ballif
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
    Proc Natl Acad Sci U S A 93:5544-9. 1996
    ..It also identifies Nuc as a potential regulator of COXs through this interaction...
  97. ncbi Myotrophin in human cardiomyopathic heart
    P Sil
    Department of Cardiovascular Biology, Cleveland Clinic Foundation, OH 44195 5071
    Circ Res 73:98-108. 1993
    ....
  98. ncbi Global analysis of gene expression in renal ischemia-reperfusion in the mouse
    Takumi Yoshida
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    Biochem Biophys Res Commun 291:787-94. 2002
    ..Our data identified several novel genes that may be important in renal repair after ischemia...
  99. ncbi Amphiregulin is a mitogen for adult neural stem cells
    Anna Falk
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    J Neurosci Res 69:757-62. 2002
    ....
  100. ncbi An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
    Paolo Michieli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    Nat Biotechnol 20:488-95. 2002
    ..In an in vivo murine model of drug-induced nephrotoxicity, intravenous injection of recombinant Metron factor 1 prevented renal damage and preserved tubular integrity...
  101. ncbi Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma
    Shibani Pati
    Institute of Human Virology, University of Maryland Biotechnology Institute, Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, USA
    Blood 99:3771-9. 2002
    ..Taken together, these data suggest that ritonavir has antineoplastic effects that are independent from its ability to inhibit the HIV protease...

Research Grants70

  1. BREAST TUMOR PROXIMAL STROMA INTERACTION AND AROMATASE
    Serdar Bulun; Fiscal Year: 2000
    ..We will determine the effects of steroids and various growth substances on cytokine expression...
  2. ETS FACTOR NERF AND B CELL FUNCTION
    J Oettgen; Fiscal Year: 2000
    ..proliferation of cells of the immune system often occur in response to external stimuli, such as antigens or growth substances. This response requires that the receptors on the surface of these cells recognize the stimulus and initiate ..
  3. EXPERIMENTAL ASBESTOS-INDUCED MESOTHELIOMA
    JOHN CRAIGHEAD; Fiscal Year: 1992
    ..The outcome of these studies will support or refute the hypothesis that pro-growth substances stimulate their replication in the course of multistage carcinogenesis...
  4. Regulation of Wound Healing by Opioid Growth Factor
    Ronald Wilson; Fiscal Year: 2005
    ..It is now appreciated that a number of growth substances participate in the healing process to coordinate the interaction between the cells involved...
  5. ANGIOGENESIS, HEALING, AND AGING IN RETINA AND CHOROID
    Michael Goldbaum; Fiscal Year: 1980
    ..In the previous two years of the project, a technique of incorporating the growth substances in Elvax for slow release into adjacent tissue was developed...
  6. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  7. Neonatal Stem Cells: Unique Traits in Paracine Signaling and Cardioprotection
    JEREMY HERRMANN; Fiscal Year: 2009
    ..Understanding the ways that stem cells help patients will allow scientists to create "super" stem cells that both survive better in stressful conditions and release protective growth substances.
  8. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  9. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  10. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  11. Nanoparticle Targeting to Control Angiogenesis
    JEFFREY DAVIDSON; Fiscal Year: 2006
    ..The objective is to design drug delivery systems that will specifically target pathological angiogenesis with minimal effects on the normal vasculature. ..
  12. ESTROGEN BIOTRANSFORMATIONS AND BREAST CANCER ETIOLOGY
    ROBERT BRUEGGEMEIER; Fiscal Year: 2006
    ..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
  13. NEUROENDOCRINE BASES OF REPRODUCTIVE BEHAVIOR
    ANNE ETGEN; Fiscal Year: 2006
    ..Specific Aim 4 will determine how IGF-1 acutely potentiates a1-adrenoceptor signaling in the HYP-POA of E2-treated females and whether this is important for reproductive behavior. ..
  14. Angiogenesis in the Pulmonary Microvasculature
    Denis English; Fiscal Year: 2007
    ..abstract_text> ..
  15. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  16. STEROID HORMONES--BRAIN AND BEHAVIOR
    ANNE ETGEN; Fiscal Year: 2007
    ..These studies will provide novel[unreadable] insights into the cellular and molecular mechanisms by which ovarian[unreadable] sterioids act in the brain and to produce predictable behavioral[unreadable] changes. ..
  17. ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOL
    Richard Santen; Fiscal Year: 2008
    ..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
  18. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2008
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
  19. Abnormalities in gene expression in therapy-related MDS
    Ravi Bhatia; Fiscal Year: 2008
    ..These studies may also allow identification of markers of susceptibility to t-MDS allowing early detection of patients at risk for this complication. ..
  20. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  21. Estrogen: Neuroprotection in the Perimenopause
    Anne M Etgen; Fiscal Year: 2010
    ..These experiments will provide new information on the potential for hormone therapy instituted during the perimenopausal transition to protect the brain from damage due to global ischemia. ..
  22. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
  23. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  24. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  25. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 2004
    ....
  26. Hypoglycemia & exercise in children with type 1 diabetes
    Pietro Galassetti; Fiscal Year: 2007
    ..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..
  27. LIPOSOMAL BCL-2 ANTISENSE THERAPY FOR SOLID TUMORS
    Francisco Esteva; Fiscal Year: 2003
    ..Gabriel Lopez-Berestein (Department of Bioimmunotherapy). M. D. Anderson Cancer Center has the patients and resources necessary for Dr. Esteva to successfully complete this research project. ..
  28. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  29. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2010
    ..abstract_text> ..
  30. The Role of IGF2 in Fetal Growth Restriction
    Pinchas Cohen; Fiscal Year: 2008
    ..abstract_text> ..
  31. GDF Modulation of Tendon Maintenance and Repair
    Borjana Mikic; Fiscal Year: 2008
    ..These studies combine to enhance our understanding of the mechanisms of action of GDFs in tendon maintenance and repair. ..
  32. NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENT
    Sergio R Ojeda; Fiscal Year: 2010
    ..4) To examine the hypothesis that a novel gene, termed EAP-1 (Enhanced At. Puberty-1) belongs - along with TTF-1 - to the hierarchy of controlling genes involved in the transcriptional regulation of the pubertal process. ..
  33. Thyroid Stimulating Hormone Promotes the Growth and Progression of Human Melanoma
    Julie Ellerhorst; Fiscal Year: 2008
    ..Furthermore, melanoma cases may be prevented by heightened surveillance of individuals with a history of hypothyroidism. [unreadable] [unreadable] [unreadable]..
  34. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 2004
    ..For example, the dual functions of ADAMs as both adhesion molecules and as proteases suggests that they may be key players in the de-adhesive, migratory, and re-adhesive activities involved in tumor metastasis. ..
  35. T cell homing in intestinal graft-versus-host disease
    Marcel van den Brink; Fiscal Year: 2009
    ..These studies will contribute to a better mechanistic understanding of intestinal GVHD and provide preclinical data for new strategies to treat or prevent intestinal GVHD, while sparing GVT activity. ..
  36. LAMININ-8 AND LAMININ-10 IN SQUAMOUS CELL CARCINOMAS
    Jie Li; Fiscal Year: 2009
    ....
  37. Axonal growth and guidance for nervous system repair
    George Smith; Fiscal Year: 2009
    ....
  38. Cyclin D1 and mammary carcinoma
    J Diehl; Fiscal Year: 2009
    ..The work proposed herein will establish the relationship between cyclin D1 nuclear retention and the function of cyclin D1 as an oncogenic protein in mammary carcinoma. ..
  39. REGULATION OF BONE REMODELING BY MEGAKARYOCYTES
    Mark Horowitz; Fiscal Year: 2009
    ..Such information would be applicable to a wide variety of skeletal defects including, post-menopausal osteoporosis, age-related osteopenia, fracture repair, and extended survival of prosthetic implants. ..
  40. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2002
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  41. GDF REGULATION OF ENDOCHONDRAL BONE GROWTH
    Borjana Mikic; Fiscal Year: 2002
    ....
  42. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  43. Mechanisms of Synovial Joint Formation
    Maurizio Pacifici; Fiscal Year: 2009
    ..The results will be invaluable in conceiving novel, directed and specific therapies to repair and restore malfunctioning joints common to aging individuals and otherwise affected patients. ..
  44. 2003 FASEB Summer Conference on Lysophospholipids
    Gabor Tigyi; Fiscal Year: 2003
    ..The conference should provide a contemporary perspective of this rapidly moving field and allow the evaluation of future directions, as well as critical review of recent research. ..
  45. Lipotrope stimulates breast cancer cell death
    Chung Park; Fiscal Year: 2003
    ..abstract_text> ..
  46. National Pharmacology Directors of Graduate Programs Meeting
    Joey Barnett; Fiscal Year: 2007
    ..A continuing dialogue among Directors of training programs and other scientists with an interest in training is identified as a desired major outcome. [unreadable] [unreadable] [unreadable]..
  47. NEURONAL DEGENERATION: MECHANISMS AND PREVENTION
    CAROL TROY; Fiscal Year: 2007
    ..4. To determine how caspases-8 and -7 are activated after SOD1 down-regulation. 5. To determine if there is activation/regulation of caspase-3 and other caspases after SOD1 down-regulation. ..
  48. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  49. Signaling Molecules and Long Bone Formation
    Maurizio Pacifici; Fiscal Year: 2005
    ..The results will provide much needed information on the regulation of long bone formation, and will have relevance to questions of skeletal growth, fracture repair and congenital conditions of cartilage and bone. ..
  50. Inhibition of Migration for PVR Treatment
    Eugene Levin; Fiscal Year: 2005
    ..Time course study to determine the minimum number of injections needed to inhibit PVR. These results will provide the basis for the eventual use of LD22-4 in the treatment of PVR. ..
  51. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
  52. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  53. Retinoic Acid Regulation of Erythropoiesis
    Henry Sucov; Fiscal Year: 2004
    ..In this Aim, I will test the hypothesis that a transition occurs in definitive erythropoiesis from regulation of Epo gene expression retinoic acid and RXRalpha to regulation by HNF4. ..
  54. Conference: Biology of Calpains in Health and Disease
    NEIL FORSBERG; Fiscal Year: 2004
    ..The proposed program will provide the forum by which the momentum in this field may be maintained. ..
  55. Identification of circadian clock output genes
    Mark Drapeau; Fiscal Year: 2006
    ..Then, some of these genes will be studied molecularly to determine how they are regulated by the central clock. ..
  56. IC Communication in Breast Cancer Metastasis to Bone
    Henry Donahue; Fiscal Year: 2005
    ..The results of this project will provide insights into the mechanism by which breast cancer cells preferentially metastasize to bone, an important step in developing approaches to inhibit bone metastasis. ..
  57. A Novel Gene Network Controlling Mammalian Puberty
    Sergio Ojeda; Fiscal Year: 2006
    ..Although siRNAs are widely used to perturb gene expression in mammalian cells, the methodology to achieve long-term silencing effects in vivo is still in its infancy. [unreadable] [unreadable]..
  58. BIOGENESIS AND FUNCTION OF CONNECTIVE TISSUE PROTEINS
    Paul Bornstein; Fiscal Year: 2004
    ..It is anticipated that some of the mutations created in mice will generate useful models for human disorders of these tissues, specifically some of the Ehlers-Danlos syndromes and osteoporosis. ..
  59. A Request for support of 25th SPRSM Meeting
    James Wang; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  60. PATHWAY OF VENTRICULAR MORPHOGENESIS MEDICATED BY RXRA
    Henry Sucov; Fiscal Year: 2001
    ..abstract_text> ..
  61. Preventing choroidal neovascularization by long-term transscleral drug delivery
    PURAN BORA; Fiscal Year: 2006
    ..For proof-of-concept, we will use a novel, human protein-based therapy that has shown great potential in preliminary animal studies. [unreadable] [unreadable] [unreadable] [unreadable]..
  62. STUDY OF REG RECEPTOR-LIGAND BIOLOGY IN GI MUCOSA
    Brian Dieckgraefe; Fiscal Year: 2008
    ..These studies will also provide new insight into the role of Reg IV antagonists and lay the groundwork for development of therapeutic reagents active in gastrointestinal adenocarcinomas. ..
  63. Near Infra Red Energy To Treat Diabetic Neuropathy
    NIGEL CALCUTT; Fiscal Year: 2006
    ..abstract_text> ..
  64. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..In addition, we will analyze the wound fluid in order to determine the temporal expression of VEGF in a diabetic ulcer. ..
  65. THE ROLE OF THE SIGNAL TRANSDUCERS IN TUMORIGENESIS
    Corinne Silva; Fiscal Year: 2004
    ..The ultimate goal is that these studies will lead to the identification of novel therapeutic methods and/or reagents for treating breast cancer. ..
  66. AASK NIH Cohort Study
    Joel Kopple; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD__ ..
  67. ALS-mutant SOD1-induced motor neuron apoptosis
    Alvaro Estevez; Fiscal Year: 2006
    ....
  68. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2005
    ..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
  69. Local Angiogenic Therapy for Diabetic Ulcers
    Harold Brem; Fiscal Year: 2006
    ..Support from this proposal will allow the applicant to use knowledge from the fields of gene therapy, angiogenesis and wound healing to develop a safe angiogenic gene therapy for diabetic foot ulcers. ..