Genomes and Genes
Summary: The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.
Publications245 found, 100 shown here
- Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophagesAisleen McColl
Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
J Immunol 183:2167-75. 2009..filtration chromatography, we identified a high molecular mass serum fraction containing C4-binding protein and protein S responsible for the augmentation of phagocytosis of apoptotic neutrophils...
- The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesT N Stitt
Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
Cell 80:661-70. 1995..These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related to protein S but lacking any ..
- Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamilySassan Hafizi
Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
FEBS J 273:5231-44. 2006Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions...
- Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complexAtsuo Suzuki
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461 8673, Japan
J Biol Chem 285:13444-53. 2010Pregnant women show a low level of protein S (PS) in plasma, which is known to be a risk for deep venous thrombosis...
- The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesisP S Crosier
Department of Molecular Medicine, University of Auckland, New Zealand
Exp Hematol 24:318-23. 1996..Ligands for Dtk and Ufo have been identified as protein S and the related molecule Gas6, respectively...
- Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaquesB Hurtado
Translational Research Laboratory, Catalan Institute of Oncology IDIBELL, L Hospitalet de Llobregat, Spain
Thromb Haemost 105:873-82. 2011The GAS6/ProS-TAM system is composed of two vitamin K-dependent ligands (GAS6 and protein S) and their three protein tyrosine kinase receptors TYRO3, AXL and MERTK, known as the TAM receptors...
- Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Childhood Thrombophilia Study GroupS Ehrenforth
Department of Internal Medicine, University Hospital Frankfurt, Germany
Eur J Pediatr 158:S97-104. 1999..APC-resistance (FV:Q506), protein C, protein S, antithrombin, heparin cofactor II (HCII), histidine-rich glycoprotein (HRGP), and prothrombin (F...
- Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general populationRina Kimura
Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
Int J Hematol 84:387-97. 2006..polymorphisms in VKORC1, GGCX, and CALU to interindividual variation in the activities of plasma protein C and protein S. We sequenced these 3 genes in 96 Japanese individuals and geno-typed 9 representative single-nucleotide ..
- Failure in the detection of aberrant mRNA from the heterozygotic splice site mutant allele for protein S in a patient with protein S deficiencyH Iida
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 812-8582, Fukuoka, Japan
Thromb Res 102:187-96. 2001..history including thrombosis in the deep veins and pulmonary infarction presented with a reduced level of both protein S (PS) activity and free PS...
- Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 familyQ Lu
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Science 293:306-11. 2001..These phenotypes are cell nonautonomous with respect to lymphocytes and result from the hyperactivation of antigen-presenting cells in which the three receptors are normally expressed...
- TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosusChang Hee Suh
Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
Arthritis Res Ther 12:R146. 2010..Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis...
- Genetic risk factors of venous thrombosisR F Franco
Laboratory for Experimental Internal Medicine, Meibergdreef 9, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Hum Genet 109:369-84. 2001..These include mutations in the genes that encode antithrombin, protein C and protein S, and the factor V Leiden and factor II G20210 A mutations...
- Cellular and molecular targets of protein S-glutathiolationRodney E Shackelford
Louisiana State University at Shreveport, Department of Pathology, Shreveport, LA, USA
Antioxid Redox Signal 7:940-50. 2005..Among these defenses, protein S-glutathiolation has emerged as an important mechanism, both in the maintenance of thiol stability during oxidant ..
- C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studiesAlfonso Buil
Unitat de Genomica de Malalties Complexes, Institut de Recerca Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Blood 115:4644-50. 2010Through its binding with protein S (PS), a key element of the coagulation/fibrinolysis cascade, the C4b-binding protein (C4BP) has been hypothesized to be involved in the susceptibility to venous thrombosis (VT)...
- Recurrent venous thromboembolism in patients with a partial deficiency of protein SP C Comp
N Engl J Med 311:1525-8. 1984b>Protein S is an antithrombotic plasma protein that serves as a cofactor for another plasma protein, activated protein C...
- Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesisTal Burstyn-Cohen
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California, USA
J Clin Invest 119:2942-53. 2009b>Protein S (ProS) is a blood anticoagulant encoded by the Pros1 gene, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity...
- In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatizationScott W Aesif
Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Pathol 175:36-45. 2009b>Protein S-glutathionylation (PSSG) is a posttranslational modification that involves the conjugation of the small antioxidant molecule glutathione to cysteine residues and is emerging as a critical mechanism of redox-based signaling...
- Factor XII but not protein C, protein S, antithrombin III, or factor XIII is a predictor of recurrent miscarriageM S Ogasawara
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan
Fertil Steril 75:916-9. 2001OBJECTIVE: To investigate whether a decrease in the values of protein C (PC), protein S (PS), antithrombin III (ATIII), factor XII (FXII), or factor XIII (FXIII) has predictive value for subsequent miscarriages. DESIGN: Prospective study...
- Micro-ribonucleic Acid 494 regulation of protein S expressionJ W Tay
Department of Hematology, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia
J Thromb Haemost 11:1547-55. 2013....
- Interaction of the protein C/protein S anticoagulant system, the endothelium and pregnancyP Clark
Department of Haematology, Royal Infirmary, Glasgow, UK
Blood Rev 13:127-46. 1999..A common feature of these abnormalities is their ability to alter endothelial function or the protein C/protein S system and increase thrombin generation...
- A novel G-to-A mutation in the intron-N of the protein S gene leading to abnormal RNA splicing in a patient with protein S deficiencyGiovanna D'Andrea
Unità di Aterosclerosi e Trombosi IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, San Giovanni Rotondo, 71013 Foggia, Italy
Haematologica 88:459-64. 2003Hereditary protein S (PS) deficiency is a rare autosomal disorder of the coagulation pathway associated with familial thrombophilia.
- Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasmaE Castoldi
Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 8:294-300. 2010b>Protein S and tissue factor pathway inhibitor (TFPI) act together in down-regulating coagulation.
- Expression of protein C (PC), protein S (PS) and thrombomodulin (TM) in human colorectal cancerEwa Sierko
Department of Oncology, Medical University, Bialystok, Poland
Thromb Res 125:e71-5. 2010..An important inhibitory mechanism is provided by the protein C (PC) system consisting of PC, protein S (PS) and thrombomodulin (TM)...
- Inappropriate use of protein C, protein S, and antithrombin testing for hereditary thrombophilia screening: an experience from a large university hospitalP Tientadakul
Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Int J Lab Hematol 33:593-600. 2011Deficiencies of protein C, protein S, and antithrombin are the main inherited risk factors in Thai patients with venous thromboembolism, although the prevalence is not high.
- Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor VaEva A Norstrøm
Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Sweden
J Biol Chem 278:24904-11. 2003..The effect of APC is potentiated by negatively charged phospholipid membranes and the APC cofactor protein S. Protein S has been reported to selectively stimulate cleavage at Arg306, an effect hypothesized to be related ..
- Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosisB Knoll
Institute for Genetic and Developmental Biology, University of Salzburg, Salzburg, Austria
Thromb Res 103:3-8. 2001..We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type ..
- Upregulation of protein S by progestinsQ Hughes
Department of Haematology, Royal Perth Hospital, Perth, WA, Australia
J Thromb Haemost 5:2243-9. 2007Users of progestin-only contraceptives have raised protein S (PS) levels compared with baseline...
- Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residueJosefin Ahnström
Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
Blood 117:6685-93. 2011b>Protein S has an important anticoagulant function by acting as a cofactor for activated protein C (APC). We recently reported that the EGF1 domain residue Asp95 is critical for APC cofactor function...
- Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4bB Dahlback
Proc Natl Acad Sci U S A 80:3461-5. 1983..In plasma and in purified form C4bp also forms a bimolecular complex (Kd = 0.9 X 10(-7) M) with protein S, a recently identified vitamin K-dependent plasma protein...
- The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibitionMatthew Ndonwi
Division of Hematology, Washington University, St Louis, MO 63110, USA
Blood 116:1344-51. 2010b>Protein S (PS) enhances the inhibition of factor Xa (FXa) by tissue factor pathway inhibitor-alpha (TFPI-alpha) in the presence of Ca(2+) and phospholipids...
- Associations between high factor VIII and low free protein S levels with traditional arterial thrombotic risk factors and their risk on arterial thrombosis: results from a retrospective family cohort studyRene Mulder
Division of Haemostasis and Thrombosis, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
Thromb Res 126:e249-54. 2010Whether high factor (F)VIII and low free protein S levels are risk factors for arterial thrombosis is unclarified.
- The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent mannerSylvain Fraineau
Institut de Physiologie et de Biologie Cellulaires, Centre National de la Recherche Scientifique, Formation de Recherche en Evolution 3511, Universite de Poitiers, Poitiers, France
Blood 120:5073-83. 2012b>Protein S is a vitamin K-dependent glycoprotein, which, besides its anticoagulant function, acts as an agonist for the tyrosine kinase receptors Tyro3, Axl, and Mer. The endothelium expresses Tyro3, Axl, and Mer and produces protein S...
- Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein SJosefin Ahnström
Centre for Haematology, Faculty of Medicine, Imperial College London, Du Cane Road, London, United Kingdom
Blood 120:5059-62. 2012b>Protein S is a cofactor for tissue factor pathway inhibitor (TFPI) that critically reduces the inhibition constant for FXa to below the plasma concentration of TFPI. TFPI Kunitz domain 3 is required for this enhancement to occur...
- Protein S gene mutation in a young woman with type III protein S deficiency and venous thrombosis during pregnancyMasaya Hirose
Department of Obstetrics and Gynecology, Shiga University of Medical Science, Ohtsu, Japan
J Thromb Thrombolysis 13:85-8. 2002We attempted to identify a gene defect in a young woman with type III protein S deficiency and venous thrombosis during pregnancy.
- Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor VaEva A Norstrøm
Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
J Biol Chem 281:31486-94. 2006..The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged...
- Plasma protein S activity correlates with protein S genotype but is not sensitive to identify K196E mutant carriersR Kimura
Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
J Thromb Haemost 4:2010-3. 2006b>Protein S (PS) is an anticoagulant protein that functions as a cofactor for activated protein C (APC), and congenital PS deficiency is a well-known risk factor for the development of deep vein thrombosis (DVT)...
- A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohortN J Beauchamp
Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK
Thromb Haemost 79:1086-91. 1998In the course of investigating the molecular basis of protein S deficiency in 31 index cases with thrombophilia, we identified seven kindred where the underlying defect was a novel A to G transition 9 bp upstream of exon 12 in intron K ..
- New quantitative total protein S-assay system for diagnosing protein S type II deficiency: clinical application of the screening system for protein S type II deficiencyTomohide Tsuda
Research and Development, Shino Test Corporation, Kanagawa, Japan
Blood Coagul Fibrinolysis 23:56-63. 2012..Deficiency of protein S, an important blood coagulation regulator, is a risk factor for VTE...
- Different effects of oral contraceptives containing different progestogens on protein S and tissue factor pathway inhibitorH A A M van Vliet
Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 6:346-51. 2008..Our objective was to study the effect of OC on the two main determinants of the APC-resistance test, free protein S and free tissue factor pathway inhibitor (TFPI).
- Regulation of the human protein S gene promoter by liver enriched transcription factorsAdrian J Hall
Academic Unit of Haematology, Henry Wellcome Laboratories for Medical Research, University of Sheffield, Sheffield, UK
Br J Haematol 135:538-46. 2006b>Protein S is expressed in a number of tissue types, one of the most physiologically relevant being the liver. However, transcriptional control of protein S gene expression is poorly understood...
- A novel splice acceptor site mutation of protein S gene in affected individuals with type I protein S deficiency: allelic exclusion of the mutant geneM Nakahara
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan
Thromb Res 101:387-93. 2001Sequencing studies of the protein S gene (PROS1) in a Japanese patient suffering from recurrent thrombosis revealed the following...
- Level of antithrombin III, protein C, protein S and other selected parameters of coagulation and fibrinolysis in the blood of the patients with recurrent deep venous thrombosisAndrzej Swiatkiewicz
Clinic of General Surgery, Medical University of Bydgoszcz, Poland
Med Sci Monit 8:CR263-8. 2002Thrombophilia is caused mainly by disturbances of hemostasis involving excessive coagulation system activation, reduction of anticoagulation system (antithrombin III, protein C, protein S, RAPC) or fibrinolytic activity.
- DNA sequence analysis of protein S deficiency--identification of four point mutations in twelve Japanese subjectsT Iwaki
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan
Semin Thromb Hemost 27:155-60. 2001The molecular basis for the hereditary type I protein S (PS) deficiency was investigated. DNA sequence analysis of 12 patients with PS deficiency in Japan identified four point mutations and three of them were novel...
- Effect of antithrombin, protein C and protein S on portal vein thrombosis in liver cirrhosis: a meta-analysisXingshun Qi
Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, China
Am J Med Sci 346:38-44. 2013The effects of antithrombin (AT), protein C (PC) and protein S (PS) on the pathogenesis of portal vein thrombosis (PVT) in liver cirrhosis remain controversial in different studies...
- An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiencyNaomi Sanda
Br J Haematol 138:663-5. 2007
- Three novel missense mutations in unrelated Japanese patients with type I and type II protein S deficiency and venous thrombosisH Fujimura
Department of Surgery II, Osaka University Medical School, Suita, Japan
Thromb Res 89:151-60. 1998A molecular analysis of protein S deficiency in three unrelated Japanese patients was performed...
- Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosisToshiyuki Miyata
National Cardiovascular Center Research Institute, Suita, Osaka, Japan
Thromb Res 124:14-8. 2009..This study was undertaken to reveal the frequency of nonsynonymous mutations of these three genes in Japanese DVT patients...
- Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiencyMaria C Pintao
Einthoven Laboratory for Experimental Vascular Medicine, C2 143, Department of Thrombosis and Haemostasis, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Hum Genet 126:449-56. 2009Hereditary protein S (PS) deficiency is an autosomal disorder caused by mutations in the PS gene (PROS1). Conventional PCR-based mutation detection identifies PROS1 point mutations in approximately 50% of the cases...
- Protein S and protein C gene mutations in Japanese deep vein thrombosis patientsSachiko Kinoshita
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3 1 1 Maedashi Fukuoka 812 8582, Japan
Clin Biochem 38:908-15. 2005..Hitherto, the constitutional background of Japanese thrombotic patients has never been systematically examined. We have performed a systematic investigation to determine pathogenesis for deep vein thrombosis in a Japanese population...
- Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomalleiSteven P Larosa
Division of Infectious Disease, Rhode Island Hospital, Gerry House 113, 593 Eddy Street, and Infectious Diseases and Microbiologic Divisions of Brown University School of Medicine, Providence, Rhode Island 02903, USA
Int J Infect Dis 10:25-31. 2006..Excessive release of these cytokines may lead to endothelial injury, depletion of naturally occurring endothelial modulators, microvascular thrombosis, organ failure, and death...
- Levels of antibodies against protein C and protein S in pregnancy and in preeclampsiaMichela Torricelli
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
J Matern Fetal Neonatal Med 22:993-9. 2009The clinical relevance of antibodies anti-protein C and anti-protein S in pregnancy remains controversial...
- Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein ST Hayashi
Department of Molecular Biology on Genetic Disease, Mie University School of Medicine, Tsu City, Japan
Blood 83:683-90. 1994A 29-year-old female patient with heterozygous congenital protein S deficiency suffering from thrombotic disease had normal levels of both total and free protein S antigen (70% and 65%, respectively), but low cofactor activity (31%) for ..
- Direct effects of protein S in ameliorating acute lung injuryT Takagi
Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Mie Prefecture, Japan
J Thromb Haemost 7:2053-63. 2009b>Protein S may exert an anticoagulant activity by enhancing the anticoagulant activity of activated protein C and/or by directly inhibiting the prothrombinase complex...
- Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patientsRina Kimura
Blood 107:1737-8. 2006
- Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein SHiroko Tsuda
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Thromb Res 105:233-9. 2002Four missense mutations, G54R, T589I, K155E, and Y595C, were identified in the protein S (PS) gene of the patients with PS deficiency and venous thrombosis...
- The association of protein S Tokushima-K196E with a risk of deep vein thrombosisMakoto Ikejiri
Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan
Int J Hematol 92:302-5. 2010..the factor V Leiden and the prothrombin-20210G>A mutation do not exist in Japanese populations, a mutation in protein S (PS) Tokushima (K196E) has been attracting attention in Japan...
- Rapid intracellular degradation of a truncated mutant protein S (Q522X)Tomio Yamazaki
Thromb Haemost 87:171-2. 2002
- In vitro characterization of missense mutations associated with quantitative protein S deficiencyH Okada
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Thromb Haemost 4:2003-9. 2006To elucidate the molecular consequences of hereditary protein S (PS) deficiency, we investigated the in vitro synthesis of the PS missense mutants in COS-1 cells and their activated protein C (APC) cofactor activities.
- Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domainHelena M Andersson
Department of Haematology, Faculty of Medicine, Imperial College London, London, UK
Blood 115:4878-85. 2010b>Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property of activated protein C (APC)...
- Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiencyHiromi Okada
Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan
Br J Haematol 126:219-25. 2004Eight distinct and potentially causative mutations were identified in eight unrelated Japanese patients with protein S (PS) deficiency, by direct DNA sequencing of the protein Salpha (PSalpha) gene-specific polymerase chain reaction ..
- Decreased protein S activity is related to the disease activity of Behcet's diseaseSeong Ryul Kwon
Department of Internal Medicine, College of Medicine, Inha University, Inchon, 400 711, South Korea
Rheumatol Int 27:39-43. 2006..see whether the active inflammation in Behcet's disease (BD) can cause a thrombotic disorder by decreasing the protein S (PS) activity, and we evaluated the relationship between the decreased PS activity and the disease activity of ..
- Normal ranges and genetic variants of antithrombin, protein C and protein S in the general Chinese population. Results of the Chinese Hemostasis Investigation on Natural Anticoagulants Study I GroupTienan Zhu
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730 Beijing, China
Haematologica 96:1033-40. 2011Inherited deficiency of antithrombin, protein C and protein S, three important, naturally occurring coagulation inhibitors, might play a major role in the occurrence of venous thromboembolism in Chinese...
- Anti-protein S antibodies following a varicella infection: detection, characterization and influence on thrombin generationV Regnault
Inserm 734 and Hospital of Nancy, France
J Thromb Haemost 3:1243-9. 2005..The 4-year-old child was found to have a severe transient protein S deficiency...
- Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitorTilman M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
Proc Natl Acad Sci U S A 103:3106-11. 2006..In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the ..
- Performance goals for the laboratory testing of antithrombin, protein C and protein SPiet Meijer
ECAT Foundation, Leiden, The Netherlands
Thromb Haemost 96:584-9. 2006..from 136 different laboratories for the assay of antithrombin (activity), protein C (activity and antigen) and protein S (activity, total and free antigen)...
- Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudinJ H Griffin
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037
Blood 79:3203-11. 1992The levels of total, free, and bound protein S and C4BP were determined using enzyme-linked immunosorbent assays (ELISAs) in plasma samples (8 males and 8 females) that were individually subjected to immunoadsorption studies in which "..
- A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency stateA C Dykes
Department of Haematology, Glasgow Royal Infirmary, Scotland, UK
Br J Haematol 113:636-41. 2001Total Protein S (tPS) and free Protein S (fPS) antigen levels were measured in 3788 healthy blood donors. Men had higher levels of both parameters than women (P < 0.001)...
- A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) projectLaura Almasy
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
Arterioscler Thromb Vasc Biol 23:508-11. 2003b>Protein S (PS) is a component of the protein C anticoagulant system. PS deficiency is associated with myocardial infarction and venous thromboembolism, two highly prevalent causes of death in industrialized nations...
- The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cellsLena Kask
Lund University, The Wallenberg Laboratory, Department of Clinical Chemistry, University Hospital Malmö S 205 02 Malmö, Sweden
J Biol Chem 279:23869-73. 2004..The major form of C4BP present in blood is composed of seven alpha-chains and one beta-chain, which binds protein S (PS)...
- Regulation of TFPI function by protein ST M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 7:165-8. 2009b>Protein S is an anticoagulant cofactor of full-length tissue factor pathway inhibitor (TFPI) that facilitates optimal factor Xa-inhibition and efficient down-regulation of thrombin generation in plasma...
- Generation and phenotypic analysis of protein S-deficient miceFrançois Saller
Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Blood 114:2307-14. 2009b>Protein S (PS) is an important natural anticoagulant with potentially multiple biologic functions. To investigate further the role of PS in vivo, we generated Pros(+/-) heterozygous mice...
- Species-specific anticoagulant and mitogenic activities of murine protein SJose A Fernandez
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Haematologica 94:1721-31. 2009..In preclinical studies using models of murine injury (e.g., sepsis and ischemic stroke), murine protein S may be required because of restrictive species specificity.
- Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiencyHiroko Tsuda
Department of Nutritional Sciences, Nakamura Gakuen University, 5 7 1 Befu, Johnan ku, Fukuoka 814 0198, Japan
Thromb Res 117:323-31. 2006..We previously identified a Tyr595Cys (Y595C) mutation of protein S (PS) in a family of a quantitative PS deficiency...
- Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like regionZhihui Zhong
Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 30:15521-34. 2010The anticoagulant factor protein S (PS) protects neurons from hypoxic/ischemic injury. However, molecular mechanisms mediating PS protection in injured neurons remain unknown...
- Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cellsMichael O Hall
Jules Stein Eye Institute, UCLA Medical Center, 100 Stein Plaza, Los Angeles, CA 90095 7008, USA
Exp Eye Res 81:581-91. 2005..b>Protein S (PS) is a vitamin K-dependent serum protein with a high degree of structural similarity to Gas6, and a well ..
- Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cellsHoward A Anderson
Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Nat Immunol 4:87-91. 2003..Serum enhances macrophage phagocytosis of apoptotic cells. Here we identified protein S as the factor responsible for serum-stimulated phagocytosis of apoptotic cells...
- Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiaeDaniel Shenton
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, P O Box 88, Manchester M60 1QD, UK
Biochem J 374:513-9. 2003The irreversible oxidation of cysteine residues can be prevented by protein S-thiolation, a process by which protein SH groups form mixed disulphides with low-molecular-mass thiols such as glutathione...
- Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptorDonghui Zhu
Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery, University of Rochester Medical Center, NY, USA
Blood 115:4963-72. 2010The anticoagulant factor protein S (PS) has direct cellular activities...
- Haemostatic changes in pregnancyBenjamin Brenner
Thrombosis and Hemostasis Unit, Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, P O Box 9602, Haifa 31096, Israel
Thromb Res 114:409-14. 2004..There is a decrease in physiological anticoagulants manifested by a significant reduction in protein S activity and by acquired activated protein C (APC) resistance...
- Study of protein C, protein S, and antithrombin III in newborns with sepsisAmal El Beshlawy
Department of Paediatrics, Faculty of Medicine, Cairo University, Egypt
Pediatr Crit Care Med 11:52-9. 2010..of this study is to clarify the effect of sepsis on the physiologic inhibition system of coagulation including protein S, protein C, and antithrombin III, and to study their further effect on thromboembolic accidents of septic ..
- Blood coagulationB Dahlback
Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
Lancet 355:1627-32. 2000..Analysis of knock-out mice has shown the relative importance of the coagulation factors in vivo. Gene therapy may soon be a therapeutic option for inherited deficiencies of factors VIII and IX...
- Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiencyY Espinosa-Parrilla
Departament de Genètica Mèdica i Molecular, Institut de Recerca Oncologica, Barcelona, Spain
Hum Mutat 14:30-9. 1999DNA sequence analysis of the protein S gene (PROS1) in 22 Spanish probands with type I or III PS deficiency, has allowed the identification of 10 different mutations and 2 new sequence variants in 15 probands...
- Plasma concentrations of growth arrest-specific protein 6 and protein S in patients with acute pancreatitisSoichiro Uehara
Department of Internal Medicine and Gastroenterology, Ohtakionsen Hospital, Hokkaido, Japan
J Gastroenterol Hepatol 24:1567-73. 2009The aim of the present study was to clarify the changes in plasma concentrations of growth arrest-specific protein 6 (Gas6) and protein S (PS) in patients with mild or severe acute pancreatitis (AP).
- Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cellsJoanna H Webb
Division of Clinical Chemistry, Department of Laboratory Medicine, University Hospital Malmo, Lund University, Sweden
J Immunol 169:2580-6. 2002..The vitamin K-dependent protein S has a high affinity for this type of phospholipid...
- High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding proteinB Dahlback
Proc Natl Acad Sci U S A 78:2512-6. 1981b>Protein S, a recently described vitamin K-dependent plasma protein, is shown to exist in two forms in plasma--free protein and in complex with C4b-binding protein...
- Protein S confers neuronal protection during ischemic/hypoxic injury in miceDong Liu
Frank P Smith Neurosurgical Research Laboratory, Division of Neurovascular Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
Circulation 107:1791-6. 2003b>Protein S is an antithrombotic factor that also exhibits mitogenic activity. Thus, we hypothesized that protein S may control cerebrovascular thrombosis in stroke and protect brain tissue from ischemic injury.
- Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replicationO Boccara
Department of Dermatology, University René DescartesParis V, 75473 Paris Cedex 15, France
Br J Dermatol 161:181-3. 2009..Laboratory data revealed disseminated intravascular coagulation and a severe transient protein S deficiency. Antiprotein S autoantibodies and active human herpesvirus-6 (HHV6) replication were demonstrated...
- Regulation of coagulation by protein SElisabetta Castoldi
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
Curr Opin Hematol 15:529-36. 2008b>Protein S has been one of the least mechanistically understood amongst the vitamin K-dependent coagulation proteins, and diagnosis of protein S deficiency and quantification of the associated thrombotic risk are not straightforward...
- Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivationLisbeth F A Maurissen
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
Blood 111:3034-41. 2008b>Protein S expresses cofactor activity for activated protein C (APC) by enhancing the APC-catalyzed proteolysis at R(306) in factor Va...
- The tale of protein S and C4b-binding protein, a story of affectionBjorn Dahlback
Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg laboratory 6th floor, University Hospital, Malmo, SE 20502 Malmo, Sweden
Thromb Haemost 98:90-6. 2007
- Novel subunit in C4b-binding protein required for protein S bindingA Hillarp
Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
J Biol Chem 263:12759-64. 1988..It also interacts with vitamin K-dependent protein S, which is involved in the regulation of the coagulation system...
- Large deletions of the PROS1 gene in a large fraction of mutation-negative patients with protein S deficiencyAnna M Johansson
Department of Cell and Organism Biology, Lund University, Lund, Sweden
Thromb Haemost 94:951-7. 2005b>Protein S deficiency is an autosomal dominant disorder that results from mutations in the PROS1 gene. Conventional mutation detection techniques fail to detect a pathogenic PROS1 mutation in approximately 50% of cases...
- The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependentJoanna H Webb
Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Sweden
Blood Coagul Fibrinolysis 14:355-9. 2003Vitamin K-dependent protein S and complement regulator C4b-binding protein (C4BP) form a high-affinity complex in plasma. We have previously shown that both free protein S and the C4BP-protein S complex can bind to apoptotic Jurkat cells...
- Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, ON, Canada
Clin Lab Haematol 28:9-13. 2006..Most physicians are under the impression that assays for protein C and protein S should not be measured at the time of diagnosis because of a high false positive rate...
- Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulantsB Brenner
Hematology Institute, Rambam Medical Center, Haifa, Israel
Br J Haematol 75:537-42. 1990..factor IX:Ag 57 U/dl; factor X:C 17 U/dl, factor X:Ag 54 U/dl; protein C activity 43 U/dl; protein C:Ag 45 U/dl; protein S:Ag 34 U/dl; levels of factors V:C and VIII:C were normal...
- Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complexSuely Meireles Rezende
Research Laboratory, Fundação Hemominas, Alameda Ezequiel Dias, 321 Belo Horizonte MG Brazil, 30130 110
Blood 103:1192-201. 2004b>Protein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa...
- Changes in haemostasis during normal pregnancyEkaterina H Uchikova
Department of Obstetrics and Gynecology, Higher Medical Institute, Plovdiv Bul Konstantin, Velichkov 9, Plovdiv, Bulgaria
Eur J Obstet Gynecol Reprod Biol 119:185-8. 2005..1) To study the changes in the haemostatic variables during normal pregnancy, and (2) to compare them with the corresponding variables in a control group of nonpregnant women...
- Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complicationsM J Paidas
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
J Thromb Haemost 3:497-501. 2005We posit that low levels of protein S (PS) and protein Z (PZ) contribute to adverse pregnancy outcome (APO).
- Prevention of thrombosis following deep arterial injury in rats by bovine activated protein C requiring co-administration of bovine protein SKarl Malm
Department of Plastic and Reconstructive Surgery, University Hospital Malmo, S 205 02 Malmo, Sweden
Thromb Haemost 90:227-34. 2003The antithrombotic effect of bovine activated protein C (bAPC) given with or without bovine protein S (bPS) was investigated in a rat model of deep arterial injury...
- Acquired protein C and protein S deficiency in HIV-infected patientsMatthias Erbe
Medical Department of Internal Medicine, Division of Angiology, University Hospital, Frankfurt Main, Germany
Clin Appl Thromb Hemost 9:325-31. 2003..In acutely ill patients, the incidence of protein S deficiency was 67% (33/49) and of protein C deficiency 25% (12/49), while at the follow-up visit the incidences ..
- Free protein S levels are elevated in familial C4b-binding protein deficiencyP C Comp
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104
Blood 76:2527-9. 1990In plasma, 40% of the protein S is free and functions as a cofactor for the anticoagulant effects of activated protein C. The remaining 60% of protein S is complexed to C4b-binding protein and is functionally inactive...
- Thrombus Formation and Antithrombotic InterventionJohn H Griffin; Fiscal Year: 2013..Project 1 (Griffin: Murine protein C and protein S proof of principle research) will focus on the initiation of signaling by activated protein C (APC) via apoER2 ..
- ONTOGENY OF THE PROTEIN C SYSTEMMarilyn Manco Johnson; Fiscal Year: 1992..differ from results found in the neonatal lamb or the mature sheep? 2) When in gestation are PC and its cofactor protein S (PS) expressed in fetal ovine plasma? 3) What is the developmental rate of rise of these proteins? 4) Is the ..
- Structure:function studies of the glucocorticoid receptorRaj Kumar; Fiscal Year: 2007..unreadable] [unreadable]..
- Novel Anticoagulant MechanismsMARY HEEB; Fiscal Year: 2006..We will find whether a ZPI polymorphism we identified affects function. ..
- FORMS OF PROSTATE SPECIFIC ANTIGEN AND HK2 IN CANCERMARY HEEB; Fiscal Year: 2003..Techniques will include protein purification, antibody and ELISA development, immunoblotting, enzyme activity assays, and peptide synthesis. ..
- Novel targets and agents to treat thrombotic disordersJohn Griffin; Fiscal Year: 2004..abstract_text> ..
- Pathophysiologies Involving Hemostasis-related GenesFrancis Castellino; Fiscal Year: 2008..abstract_text> ..
- Epidemiologic Study of Placental AbruptionCande Ananth; Fiscal Year: 2006..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
- Structure-based In silico Screen for Small Molecule Inhibitors of Ets-1 ActivityAlan Rigby; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGYHartmut Weiler; Fiscal Year: 2007..abstract_text> ..
- AIDS ASSOCIATED MALIGNANCIES CLINICAL TRIALS CONSORTIUMAlexandra Levine; Fiscal Year: 2005..The expertise of our labs and experience will be available to the AMC, which will be considered of the highest priority for our Group. ..
- Association of Thrombophilia and Inflammation with Post-Thrombotic SyndromeMary Cushman; Fiscal Year: 2008..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
- Gas6/Mertk mediated phagocytosis of OS by RPE cellsMichael Hall; Fiscal Year: 2005..abstract_text> ..
- Stabilized factor VIIIa as improved therapy for hemophilia AANDREW GALE; Fiscal Year: 2008..This treatment could improve the quality of life and overall health of the hemophilia A sufferers. ..
- Structure/Function Study of the Anticoagulant Protein SAlan Rigby; Fiscal Year: 2005..mechanism for regulating thrombin formation, whereby activated protein C (APC) in association with its cofactor protein S enhances the inactivation of factor Va (FVa) and factor VIIIa (FVIIIa)...
- PDE3 Inhibitors: Selective Blockers of Oocyte MaturationJeffrey Jensen; Fiscal Year: 2007..This approach is expected to provide a foundation for future Phase 1 trials of PDE3 inhibitors in humans. ..