protein s

Summary

Summary: The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.

Top Publications

  1. ncbi Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages
    Aisleen McColl
    Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 183:2167-75. 2009
  2. ncbi The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    T N Stitt
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
    Cell 80:661-70. 1995
  3. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
  4. pmc Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex
    Atsuo Suzuki
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461 8673, Japan
    J Biol Chem 285:13444-53. 2010
  5. ncbi The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis
    P S Crosier
    Department of Molecular Medicine, University of Auckland, New Zealand
    Exp Hematol 24:318-23. 1996
  6. ncbi Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques
    B Hurtado
    Translational Research Laboratory, Catalan Institute of Oncology IDIBELL, L Hospitalet de Llobregat, Spain
    Thromb Haemost 105:873-82. 2011
  7. ncbi Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Childhood Thrombophilia Study Group
    S Ehrenforth
    Department of Internal Medicine, University Hospital Frankfurt, Germany
    Eur J Pediatr 158:S97-104. 1999
  8. ncbi Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
    Rina Kimura
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Int J Hematol 84:387-97. 2006
  9. ncbi Failure in the detection of aberrant mRNA from the heterozygotic splice site mutant allele for protein S in a patient with protein S deficiency
    H Iida
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 812-8582, Fukuoka, Japan
    Thromb Res 102:187-96. 2001
  10. ncbi Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    Q Lu
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 293:306-11. 2001

Research Grants

Detail Information

Publications245 found, 100 shown here

  1. ncbi Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages
    Aisleen McColl
    Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 183:2167-75. 2009
    ..filtration chromatography, we identified a high molecular mass serum fraction containing C4-binding protein and protein S responsible for the augmentation of phagocytosis of apoptotic neutrophils...
  2. ncbi The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    T N Stitt
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
    Cell 80:661-70. 1995
    ..These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related to protein S but lacking any ..
  3. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
    Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions...
  4. pmc Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex
    Atsuo Suzuki
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461 8673, Japan
    J Biol Chem 285:13444-53. 2010
    Pregnant women show a low level of protein S (PS) in plasma, which is known to be a risk for deep venous thrombosis...
  5. ncbi The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis
    P S Crosier
    Department of Molecular Medicine, University of Auckland, New Zealand
    Exp Hematol 24:318-23. 1996
    ..Ligands for Dtk and Ufo have been identified as protein S and the related molecule Gas6, respectively...
  6. ncbi Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques
    B Hurtado
    Translational Research Laboratory, Catalan Institute of Oncology IDIBELL, L Hospitalet de Llobregat, Spain
    Thromb Haemost 105:873-82. 2011
    The GAS6/ProS-TAM system is composed of two vitamin K-dependent ligands (GAS6 and protein S) and their three protein tyrosine kinase receptors TYRO3, AXL and MERTK, known as the TAM receptors...
  7. ncbi Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Childhood Thrombophilia Study Group
    S Ehrenforth
    Department of Internal Medicine, University Hospital Frankfurt, Germany
    Eur J Pediatr 158:S97-104. 1999
    ..APC-resistance (FV:Q506), protein C, protein S, antithrombin, heparin cofactor II (HCII), histidine-rich glycoprotein (HRGP), and prothrombin (F...
  8. ncbi Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
    Rina Kimura
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Int J Hematol 84:387-97. 2006
    ..polymorphisms in VKORC1, GGCX, and CALU to interindividual variation in the activities of plasma protein C and protein S. We sequenced these 3 genes in 96 Japanese individuals and geno-typed 9 representative single-nucleotide ..
  9. ncbi Failure in the detection of aberrant mRNA from the heterozygotic splice site mutant allele for protein S in a patient with protein S deficiency
    H Iida
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 812-8582, Fukuoka, Japan
    Thromb Res 102:187-96. 2001
    ..history including thrombosis in the deep veins and pulmonary infarction presented with a reduced level of both protein S (PS) activity and free PS...
  10. ncbi Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    Q Lu
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 293:306-11. 2001
    ..These phenotypes are cell nonautonomous with respect to lymphocytes and result from the hyperactivation of antigen-presenting cells in which the three receptors are normally expressed...
  11. pmc TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus
    Chang Hee Suh
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arthritis Res Ther 12:R146. 2010
    ..Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis...
  12. ncbi Genetic risk factors of venous thrombosis
    R F Franco
    Laboratory for Experimental Internal Medicine, Meibergdreef 9, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Hum Genet 109:369-84. 2001
    ..These include mutations in the genes that encode antithrombin, protein C and protein S, and the factor V Leiden and factor II G20210 A mutations...
  13. ncbi Cellular and molecular targets of protein S-glutathiolation
    Rodney E Shackelford
    Louisiana State University at Shreveport, Department of Pathology, Shreveport, LA, USA
    Antioxid Redox Signal 7:940-50. 2005
    ..Among these defenses, protein S-glutathiolation has emerged as an important mechanism, both in the maintenance of thiol stability during oxidant ..
  14. pmc C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies
    Alfonso Buil
    Unitat de Genomica de Malalties Complexes, Institut de Recerca Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Blood 115:4644-50. 2010
    Through its binding with protein S (PS), a key element of the coagulation/fibrinolysis cascade, the C4b-binding protein (C4BP) has been hypothesized to be involved in the susceptibility to venous thrombosis (VT)...
  15. ncbi Recurrent venous thromboembolism in patients with a partial deficiency of protein S
    P C Comp
    N Engl J Med 311:1525-8. 1984
    b>Protein S is an antithrombotic plasma protein that serves as a cofactor for another plasma protein, activated protein C...
  16. pmc Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
    Tal Burstyn-Cohen
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California, USA
    J Clin Invest 119:2942-53. 2009
    b>Protein S (ProS) is a blood anticoagulant encoded by the Pros1 gene, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity...
  17. pmc In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Pathol 175:36-45. 2009
    b>Protein S-glutathionylation (PSSG) is a posttranslational modification that involves the conjugation of the small antioxidant molecule glutathione to cysteine residues and is emerging as a critical mechanism of redox-based signaling...
  18. ncbi Factor XII but not protein C, protein S, antithrombin III, or factor XIII is a predictor of recurrent miscarriage
    M S Ogasawara
    Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan
    Fertil Steril 75:916-9. 2001
    OBJECTIVE: To investigate whether a decrease in the values of protein C (PC), protein S (PS), antithrombin III (ATIII), factor XII (FXII), or factor XIII (FXIII) has predictive value for subsequent miscarriages. DESIGN: Prospective study...
  19. ncbi Micro-ribonucleic Acid 494 regulation of protein S expression
    J W Tay
    Department of Hematology, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia
    J Thromb Haemost 11:1547-55. 2013
    ....
  20. ncbi Interaction of the protein C/protein S anticoagulant system, the endothelium and pregnancy
    P Clark
    Department of Haematology, Royal Infirmary, Glasgow, UK
    Blood Rev 13:127-46. 1999
    ..A common feature of these abnormalities is their ability to alter endothelial function or the protein C/protein S system and increase thrombin generation...
  21. ncbi A novel G-to-A mutation in the intron-N of the protein S gene leading to abnormal RNA splicing in a patient with protein S deficiency
    Giovanna D'Andrea
    Unità di Aterosclerosi e Trombosi IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, San Giovanni Rotondo, 71013 Foggia, Italy
    Haematologica 88:459-64. 2003
    Hereditary protein S (PS) deficiency is a rare autosomal disorder of the coagulation pathway associated with familial thrombophilia.
  22. ncbi Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma
    E Castoldi
    Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 8:294-300. 2010
    b>Protein S and tissue factor pathway inhibitor (TFPI) act together in down-regulating coagulation.
  23. ncbi Expression of protein C (PC), protein S (PS) and thrombomodulin (TM) in human colorectal cancer
    Ewa Sierko
    Department of Oncology, Medical University, Bialystok, Poland
    Thromb Res 125:e71-5. 2010
    ..An important inhibitory mechanism is provided by the protein C (PC) system consisting of PC, protein S (PS) and thrombomodulin (TM)...
  24. ncbi Inappropriate use of protein C, protein S, and antithrombin testing for hereditary thrombophilia screening: an experience from a large university hospital
    P Tientadakul
    Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Int J Lab Hematol 33:593-600. 2011
    Deficiencies of protein C, protein S, and antithrombin are the main inherited risk factors in Thai patients with venous thromboembolism, although the prevalence is not high.
  25. ncbi Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va
    Eva A Norstrøm
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Sweden
    J Biol Chem 278:24904-11. 2003
    ..The effect of APC is potentiated by negatively charged phospholipid membranes and the APC cofactor protein S. Protein S has been reported to selectively stimulate cleavage at Arg306, an effect hypothesized to be related ..
  26. ncbi Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis
    B Knoll
    Institute for Genetic and Developmental Biology, University of Salzburg, Salzburg, Austria
    Thromb Res 103:3-8. 2001
    ..We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type ..
  27. ncbi Upregulation of protein S by progestins
    Q Hughes
    Department of Haematology, Royal Perth Hospital, Perth, WA, Australia
    J Thromb Haemost 5:2243-9. 2007
    Users of progestin-only contraceptives have raised protein S (PS) levels compared with baseline...
  28. ncbi Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue
    Josefin Ahnström
    Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
    Blood 117:6685-93. 2011
    b>Protein S has an important anticoagulant function by acting as a cofactor for activated protein C (APC). We recently reported that the EGF1 domain residue Asp95 is critical for APC cofactor function...
  29. pmc Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b
    B Dahlback
    Proc Natl Acad Sci U S A 80:3461-5. 1983
    ..In plasma and in purified form C4bp also forms a bimolecular complex (Kd = 0.9 X 10(-7) M) with protein S, a recently identified vitamin K-dependent plasma protein...
  30. pmc The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibition
    Matthew Ndonwi
    Division of Hematology, Washington University, St Louis, MO 63110, USA
    Blood 116:1344-51. 2010
    b>Protein S (PS) enhances the inhibition of factor Xa (FXa) by tissue factor pathway inhibitor-alpha (TFPI-alpha) in the presence of Ca(2+) and phospholipids...
  31. ncbi Associations between high factor VIII and low free protein S levels with traditional arterial thrombotic risk factors and their risk on arterial thrombosis: results from a retrospective family cohort study
    Rene Mulder
    Division of Haemostasis and Thrombosis, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
    Thromb Res 126:e249-54. 2010
    Whether high factor (F)VIII and low free protein S levels are risk factors for arterial thrombosis is unclarified.
  32. ncbi The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner
    Sylvain Fraineau
    Institut de Physiologie et de Biologie Cellulaires, Centre National de la Recherche Scientifique, Formation de Recherche en Evolution 3511, Universite de Poitiers, Poitiers, France
    Blood 120:5073-83. 2012
    b>Protein S is a vitamin K-dependent glycoprotein, which, besides its anticoagulant function, acts as an agonist for the tyrosine kinase receptors Tyro3, Axl, and Mer. The endothelium expresses Tyro3, Axl, and Mer and produces protein S...
  33. ncbi Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S
    Josefin Ahnström
    Centre for Haematology, Faculty of Medicine, Imperial College London, Du Cane Road, London, United Kingdom
    Blood 120:5059-62. 2012
    b>Protein S is a cofactor for tissue factor pathway inhibitor (TFPI) that critically reduces the inhibition constant for FXa to below the plasma concentration of TFPI. TFPI Kunitz domain 3 is required for this enhancement to occur...
  34. ncbi Protein S gene mutation in a young woman with type III protein S deficiency and venous thrombosis during pregnancy
    Masaya Hirose
    Department of Obstetrics and Gynecology, Shiga University of Medical Science, Ohtsu, Japan
    J Thromb Thrombolysis 13:85-8. 2002
    We attempted to identify a gene defect in a young woman with type III protein S deficiency and venous thrombosis during pregnancy.
  35. ncbi Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va
    Eva A Norstrøm
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
    J Biol Chem 281:31486-94. 2006
    ..The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged...
  36. ncbi Plasma protein S activity correlates with protein S genotype but is not sensitive to identify K196E mutant carriers
    R Kimura
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    J Thromb Haemost 4:2010-3. 2006
    b>Protein S (PS) is an anticoagulant protein that functions as a cofactor for activated protein C (APC), and congenital PS deficiency is a well-known risk factor for the development of deep vein thrombosis (DVT)...
  37. ncbi A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort
    N J Beauchamp
    Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK
    Thromb Haemost 79:1086-91. 1998
    In the course of investigating the molecular basis of protein S deficiency in 31 index cases with thrombophilia, we identified seven kindred where the underlying defect was a novel A to G transition 9 bp upstream of exon 12 in intron K ..
  38. ncbi New quantitative total protein S-assay system for diagnosing protein S type II deficiency: clinical application of the screening system for protein S type II deficiency
    Tomohide Tsuda
    Research and Development, Shino Test Corporation, Kanagawa, Japan
    Blood Coagul Fibrinolysis 23:56-63. 2012
    ..Deficiency of protein S, an important blood coagulation regulator, is a risk factor for VTE...
  39. ncbi Different effects of oral contraceptives containing different progestogens on protein S and tissue factor pathway inhibitor
    H A A M van Vliet
    Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:346-51. 2008
    ..Our objective was to study the effect of OC on the two main determinants of the APC-resistance test, free protein S and free tissue factor pathway inhibitor (TFPI).
  40. ncbi Regulation of the human protein S gene promoter by liver enriched transcription factors
    Adrian J Hall
    Academic Unit of Haematology, Henry Wellcome Laboratories for Medical Research, University of Sheffield, Sheffield, UK
    Br J Haematol 135:538-46. 2006
    b>Protein S is expressed in a number of tissue types, one of the most physiologically relevant being the liver. However, transcriptional control of protein S gene expression is poorly understood...
  41. ncbi A novel splice acceptor site mutation of protein S gene in affected individuals with type I protein S deficiency: allelic exclusion of the mutant gene
    M Nakahara
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan
    Thromb Res 101:387-93. 2001
    Sequencing studies of the protein S gene (PROS1) in a Japanese patient suffering from recurrent thrombosis revealed the following...
  42. ncbi Level of antithrombin III, protein C, protein S and other selected parameters of coagulation and fibrinolysis in the blood of the patients with recurrent deep venous thrombosis
    Andrzej Swiatkiewicz
    Clinic of General Surgery, Medical University of Bydgoszcz, Poland
    Med Sci Monit 8:CR263-8. 2002
    Thrombophilia is caused mainly by disturbances of hemostasis involving excessive coagulation system activation, reduction of anticoagulation system (antithrombin III, protein C, protein S, RAPC) or fibrinolytic activity.
  43. ncbi DNA sequence analysis of protein S deficiency--identification of four point mutations in twelve Japanese subjects
    T Iwaki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan
    Semin Thromb Hemost 27:155-60. 2001
    The molecular basis for the hereditary type I protein S (PS) deficiency was investigated. DNA sequence analysis of 12 patients with PS deficiency in Japan identified four point mutations and three of them were novel...
  44. ncbi Effect of antithrombin, protein C and protein S on portal vein thrombosis in liver cirrhosis: a meta-analysis
    Xingshun Qi
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, China
    Am J Med Sci 346:38-44. 2013
    The effects of antithrombin (AT), protein C (PC) and protein S (PS) on the pathogenesis of portal vein thrombosis (PVT) in liver cirrhosis remain controversial in different studies...
  45. ncbi An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiency
    Naomi Sanda
    Br J Haematol 138:663-5. 2007
  46. ncbi Three novel missense mutations in unrelated Japanese patients with type I and type II protein S deficiency and venous thrombosis
    H Fujimura
    Department of Surgery II, Osaka University Medical School, Suita, Japan
    Thromb Res 89:151-60. 1998
    A molecular analysis of protein S deficiency in three unrelated Japanese patients was performed...
  47. ncbi Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis
    Toshiyuki Miyata
    National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Thromb Res 124:14-8. 2009
    ..This study was undertaken to reveal the frequency of nonsynonymous mutations of these three genes in Japanese DVT patients...
  48. pmc Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency
    Maria C Pintao
    Einthoven Laboratory for Experimental Vascular Medicine, C2 143, Department of Thrombosis and Haemostasis, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Hum Genet 126:449-56. 2009
    Hereditary protein S (PS) deficiency is an autosomal disorder caused by mutations in the PS gene (PROS1). Conventional PCR-based mutation detection identifies PROS1 point mutations in approximately 50% of the cases...
  49. ncbi Protein S and protein C gene mutations in Japanese deep vein thrombosis patients
    Sachiko Kinoshita
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3 1 1 Maedashi Fukuoka 812 8582, Japan
    Clin Biochem 38:908-15. 2005
    ..Hitherto, the constitutional background of Japanese thrombotic patients has never been systematically examined. We have performed a systematic investigation to determine pathogenesis for deep vein thrombosis in a Japanese population...
  50. ncbi Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei
    Steven P Larosa
    Division of Infectious Disease, Rhode Island Hospital, Gerry House 113, 593 Eddy Street, and Infectious Diseases and Microbiologic Divisions of Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Int J Infect Dis 10:25-31. 2006
    ..Excessive release of these cytokines may lead to endothelial injury, depletion of naturally occurring endothelial modulators, microvascular thrombosis, organ failure, and death...
  51. ncbi Levels of antibodies against protein C and protein S in pregnancy and in preeclampsia
    Michela Torricelli
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    J Matern Fetal Neonatal Med 22:993-9. 2009
    The clinical relevance of antibodies anti-protein C and anti-protein S in pregnancy remains controversial...
  52. ncbi Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S
    T Hayashi
    Department of Molecular Biology on Genetic Disease, Mie University School of Medicine, Tsu City, Japan
    Blood 83:683-90. 1994
    A 29-year-old female patient with heterozygous congenital protein S deficiency suffering from thrombotic disease had normal levels of both total and free protein S antigen (70% and 65%, respectively), but low cofactor activity (31%) for ..
  53. ncbi Direct effects of protein S in ameliorating acute lung injury
    T Takagi
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Mie Prefecture, Japan
    J Thromb Haemost 7:2053-63. 2009
    b>Protein S may exert an anticoagulant activity by enhancing the anticoagulant activity of activated protein C and/or by directly inhibiting the prothrombinase complex...
  54. ncbi Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients
    Rina Kimura
    Blood 107:1737-8. 2006
  55. ncbi Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S
    Hiroko Tsuda
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Thromb Res 105:233-9. 2002
    Four missense mutations, G54R, T589I, K155E, and Y595C, were identified in the protein S (PS) gene of the patients with PS deficiency and venous thrombosis...
  56. ncbi The association of protein S Tokushima-K196E with a risk of deep vein thrombosis
    Makoto Ikejiri
    Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Hematol 92:302-5. 2010
    ..the factor V Leiden and the prothrombin-20210G>A mutation do not exist in Japanese populations, a mutation in protein S (PS) Tokushima (K196E) has been attracting attention in Japan...
  57. ncbi Rapid intracellular degradation of a truncated mutant protein S (Q522X)
    Tomio Yamazaki
    Thromb Haemost 87:171-2. 2002
  58. ncbi In vitro characterization of missense mutations associated with quantitative protein S deficiency
    H Okada
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Thromb Haemost 4:2003-9. 2006
    To elucidate the molecular consequences of hereditary protein S (PS) deficiency, we investigated the in vitro synthesis of the PS missense mutants in COS-1 cells and their activated protein C (APC) cofactor activities.
  59. pmc Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
    Helena M Andersson
    Department of Haematology, Faculty of Medicine, Imperial College London, London, UK
    Blood 115:4878-85. 2010
    b>Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property of activated protein C (APC)...
  60. ncbi Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency
    Hiromi Okada
    Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan
    Br J Haematol 126:219-25. 2004
    Eight distinct and potentially causative mutations were identified in eight unrelated Japanese patients with protein S (PS) deficiency, by direct DNA sequencing of the protein Salpha (PSalpha) gene-specific polymerase chain reaction ..
  61. ncbi Decreased protein S activity is related to the disease activity of Behcet's disease
    Seong Ryul Kwon
    Department of Internal Medicine, College of Medicine, Inha University, Inchon, 400 711, South Korea
    Rheumatol Int 27:39-43. 2006
    ..see whether the active inflammation in Behcet's disease (BD) can cause a thrombotic disorder by decreasing the protein S (PS) activity, and we evaluated the relationship between the decreased PS activity and the disease activity of ..
  62. pmc Normal ranges and genetic variants of antithrombin, protein C and protein S in the general Chinese population. Results of the Chinese Hemostasis Investigation on Natural Anticoagulants Study I Group
    Tienan Zhu
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730 Beijing, China
    Haematologica 96:1033-40. 2011
    Inherited deficiency of antithrombin, protein C and protein S, three important, naturally occurring coagulation inhibitors, might play a major role in the occurrence of venous thromboembolism in Chinese...
  63. ncbi Anti-protein S antibodies following a varicella infection: detection, characterization and influence on thrombin generation
    V Regnault
    Inserm 734 and Hospital of Nancy, France
    J Thromb Haemost 3:1243-9. 2005
    ..The 4-year-old child was found to have a severe transient protein S deficiency...
  64. pmc Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor
    Tilman M Hackeng
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Proc Natl Acad Sci U S A 103:3106-11. 2006
    ..In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the ..
  65. ncbi Performance goals for the laboratory testing of antithrombin, protein C and protein S
    Piet Meijer
    ECAT Foundation, Leiden, The Netherlands
    Thromb Haemost 96:584-9. 2006
    ..from 136 different laboratories for the assay of antithrombin (activity), protein C (activity and antigen) and protein S (activity, total and free antigen)...
  66. ncbi Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin
    J H Griffin
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037
    Blood 79:3203-11. 1992
    The levels of total, free, and bound protein S and C4BP were determined using enzyme-linked immunosorbent assays (ELISAs) in plasma samples (8 males and 8 females) that were individually subjected to immunoadsorption studies in which "..
  67. ncbi A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state
    A C Dykes
    Department of Haematology, Glasgow Royal Infirmary, Scotland, UK
    Br J Haematol 113:636-41. 2001
    Total Protein S (tPS) and free Protein S (fPS) antigen levels were measured in 3788 healthy blood donors. Men had higher levels of both parameters than women (P < 0.001)...
  68. ncbi A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 23:508-11. 2003
    b>Protein S (PS) is a component of the protein C anticoagulant system. PS deficiency is associated with myocardial infarction and venous thromboembolism, two highly prevalent causes of death in industrialized nations...
  69. ncbi The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells
    Lena Kask
    Lund University, The Wallenberg Laboratory, Department of Clinical Chemistry, University Hospital Malmö S 205 02 Malmö, Sweden
    J Biol Chem 279:23869-73. 2004
    ..The major form of C4BP present in blood is composed of seven alpha-chains and one beta-chain, which binds protein S (PS)...
  70. ncbi Regulation of TFPI function by protein S
    T M Hackeng
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 7:165-8. 2009
    b>Protein S is an anticoagulant cofactor of full-length tissue factor pathway inhibitor (TFPI) that facilitates optimal factor Xa-inhibition and efficient down-regulation of thrombin generation in plasma...
  71. pmc Generation and phenotypic analysis of protein S-deficient mice
    François Saller
    Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Blood 114:2307-14. 2009
    b>Protein S (PS) is an important natural anticoagulant with potentially multiple biologic functions. To investigate further the role of PS in vivo, we generated Pros(+/-) heterozygous mice...
  72. pmc Species-specific anticoagulant and mitogenic activities of murine protein S
    Jose A Fernandez
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Haematologica 94:1721-31. 2009
    ..In preclinical studies using models of murine injury (e.g., sepsis and ischemic stroke), murine protein S may be required because of restrictive species specificity.
  73. ncbi Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency
    Hiroko Tsuda
    Department of Nutritional Sciences, Nakamura Gakuen University, 5 7 1 Befu, Johnan ku, Fukuoka 814 0198, Japan
    Thromb Res 117:323-31. 2006
    ..We previously identified a Tyr595Cys (Y595C) mutation of protein S (PS) in a family of a quantitative PS deficiency...
  74. pmc Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region
    Zhihui Zhong
    Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:15521-34. 2010
    The anticoagulant factor protein S (PS) protects neurons from hypoxic/ischemic injury. However, molecular mechanisms mediating PS protection in injured neurons remain unknown...
  75. ncbi Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells
    Michael O Hall
    Jules Stein Eye Institute, UCLA Medical Center, 100 Stein Plaza, Los Angeles, CA 90095 7008, USA
    Exp Eye Res 81:581-91. 2005
    ..b>Protein S (PS) is a vitamin K-dependent serum protein with a high degree of structural similarity to Gas6, and a well ..
  76. ncbi Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells
    Howard A Anderson
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Nat Immunol 4:87-91. 2003
    ..Serum enhances macrophage phagocytosis of apoptotic cells. Here we identified protein S as the factor responsible for serum-stimulated phagocytosis of apoptotic cells...
  77. pmc Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae
    Daniel Shenton
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, P O Box 88, Manchester M60 1QD, UK
    Biochem J 374:513-9. 2003
    The irreversible oxidation of cysteine residues can be prevented by protein S-thiolation, a process by which protein SH groups form mixed disulphides with low-molecular-mass thiols such as glutathione...
  78. pmc Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor
    Donghui Zhu
    Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery, University of Rochester Medical Center, NY, USA
    Blood 115:4963-72. 2010
    The anticoagulant factor protein S (PS) has direct cellular activities...
  79. ncbi Haemostatic changes in pregnancy
    Benjamin Brenner
    Thrombosis and Hemostasis Unit, Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, P O Box 9602, Haifa 31096, Israel
    Thromb Res 114:409-14. 2004
    ..There is a decrease in physiological anticoagulants manifested by a significant reduction in protein S activity and by acquired activated protein C (APC) resistance...
  80. ncbi Study of protein C, protein S, and antithrombin III in newborns with sepsis
    Amal El Beshlawy
    Department of Paediatrics, Faculty of Medicine, Cairo University, Egypt
    Pediatr Crit Care Med 11:52-9. 2010
    ..of this study is to clarify the effect of sepsis on the physiologic inhibition system of coagulation including protein S, protein C, and antithrombin III, and to study their further effect on thromboembolic accidents of septic ..
  81. ncbi Blood coagulation
    B Dahlback
    Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    Lancet 355:1627-32. 2000
    ..Analysis of knock-out mice has shown the relative importance of the coagulation factors in vivo. Gene therapy may soon be a therapeutic option for inherited deficiencies of factors VIII and IX...
  82. ncbi Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency
    Y Espinosa-Parrilla
    Departament de Genètica Mèdica i Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Hum Mutat 14:30-9. 1999
    DNA sequence analysis of the protein S gene (PROS1) in 22 Spanish probands with type I or III PS deficiency, has allowed the identification of 10 different mutations and 2 new sequence variants in 15 probands...
  83. ncbi Plasma concentrations of growth arrest-specific protein 6 and protein S in patients with acute pancreatitis
    Soichiro Uehara
    Department of Internal Medicine and Gastroenterology, Ohtakionsen Hospital, Hokkaido, Japan
    J Gastroenterol Hepatol 24:1567-73. 2009
    The aim of the present study was to clarify the changes in plasma concentrations of growth arrest-specific protein 6 (Gas6) and protein S (PS) in patients with mild or severe acute pancreatitis (AP).
  84. ncbi Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells
    Joanna H Webb
    Division of Clinical Chemistry, Department of Laboratory Medicine, University Hospital Malmo, Lund University, Sweden
    J Immunol 169:2580-6. 2002
    ..The vitamin K-dependent protein S has a high affinity for this type of phospholipid...
  85. pmc High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein
    B Dahlback
    Proc Natl Acad Sci U S A 78:2512-6. 1981
    b>Protein S, a recently described vitamin K-dependent plasma protein, is shown to exist in two forms in plasma--free protein and in complex with C4b-binding protein...
  86. ncbi Protein S confers neuronal protection during ischemic/hypoxic injury in mice
    Dong Liu
    Frank P Smith Neurosurgical Research Laboratory, Division of Neurovascular Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
    Circulation 107:1791-6. 2003
    b>Protein S is an antithrombotic factor that also exhibits mitogenic activity. Thus, we hypothesized that protein S may control cerebrovascular thrombosis in stroke and protect brain tissue from ischemic injury.
  87. ncbi Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication
    O Boccara
    Department of Dermatology, University René DescartesParis V, 75473 Paris Cedex 15, France
    Br J Dermatol 161:181-3. 2009
    ..Laboratory data revealed disseminated intravascular coagulation and a severe transient protein S deficiency. Antiprotein S autoantibodies and active human herpesvirus-6 (HHV6) replication were demonstrated...
  88. ncbi Regulation of coagulation by protein S
    Elisabetta Castoldi
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Curr Opin Hematol 15:529-36. 2008
    b>Protein S has been one of the least mechanistically understood amongst the vitamin K-dependent coagulation proteins, and diagnosis of protein S deficiency and quantification of the associated thrombotic risk are not straightforward...
  89. ncbi Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation
    Lisbeth F A Maurissen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    Blood 111:3034-41. 2008
    b>Protein S expresses cofactor activity for activated protein C (APC) by enhancing the APC-catalyzed proteolysis at R(306) in factor Va...
  90. ncbi The tale of protein S and C4b-binding protein, a story of affection
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg laboratory 6th floor, University Hospital, Malmo, SE 20502 Malmo, Sweden
    Thromb Haemost 98:90-6. 2007
  91. ncbi Novel subunit in C4b-binding protein required for protein S binding
    A Hillarp
    Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
    J Biol Chem 263:12759-64. 1988
    ..It also interacts with vitamin K-dependent protein S, which is involved in the regulation of the coagulation system...
  92. ncbi Large deletions of the PROS1 gene in a large fraction of mutation-negative patients with protein S deficiency
    Anna M Johansson
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Thromb Haemost 94:951-7. 2005
    b>Protein S deficiency is an autosomal dominant disorder that results from mutations in the PROS1 gene. Conventional mutation detection techniques fail to detect a pathogenic PROS1 mutation in approximately 50% of cases...
  93. ncbi The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependent
    Joanna H Webb
    Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Sweden
    Blood Coagul Fibrinolysis 14:355-9. 2003
    Vitamin K-dependent protein S and complement regulator C4b-binding protein (C4BP) form a high-affinity complex in plasma. We have previously shown that both free protein S and the C4BP-protein S complex can bind to apoptotic Jurkat cells...
  94. ncbi Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, ON, Canada
    Clin Lab Haematol 28:9-13. 2006
    ..Most physicians are under the impression that assays for protein C and protein S should not be measured at the time of diagnosis because of a high false positive rate...
  95. ncbi Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulants
    B Brenner
    Hematology Institute, Rambam Medical Center, Haifa, Israel
    Br J Haematol 75:537-42. 1990
    ..factor IX:Ag 57 U/dl; factor X:C 17 U/dl, factor X:Ag 54 U/dl; protein C activity 43 U/dl; protein C:Ag 45 U/dl; protein S:Ag 34 U/dl; levels of factors V:C and VIII:C were normal...
  96. ncbi Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex
    Suely Meireles Rezende
    Research Laboratory, Fundação Hemominas, Alameda Ezequiel Dias, 321 Belo Horizonte MG Brazil, 30130 110
    Blood 103:1192-201. 2004
    b>Protein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa...
  97. ncbi Changes in haemostasis during normal pregnancy
    Ekaterina H Uchikova
    Department of Obstetrics and Gynecology, Higher Medical Institute, Plovdiv Bul Konstantin, Velichkov 9, Plovdiv, Bulgaria
    Eur J Obstet Gynecol Reprod Biol 119:185-8. 2005
    ..1) To study the changes in the haemostatic variables during normal pregnancy, and (2) to compare them with the corresponding variables in a control group of nonpregnant women...
  98. ncbi Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications
    M J Paidas
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Thromb Haemost 3:497-501. 2005
    We posit that low levels of protein S (PS) and protein Z (PZ) contribute to adverse pregnancy outcome (APO).
  99. ncbi Prevention of thrombosis following deep arterial injury in rats by bovine activated protein C requiring co-administration of bovine protein S
    Karl Malm
    Department of Plastic and Reconstructive Surgery, University Hospital Malmo, S 205 02 Malmo, Sweden
    Thromb Haemost 90:227-34. 2003
    The antithrombotic effect of bovine activated protein C (bAPC) given with or without bovine protein S (bPS) was investigated in a rat model of deep arterial injury...
  100. ncbi Acquired protein C and protein S deficiency in HIV-infected patients
    Matthias Erbe
    Medical Department of Internal Medicine, Division of Angiology, University Hospital, Frankfurt Main, Germany
    Clin Appl Thromb Hemost 9:325-31. 2003
    ..In acutely ill patients, the incidence of protein S deficiency was 67% (33/49) and of protein C deficiency 25% (12/49), while at the follow-up visit the incidences ..
  101. ncbi Free protein S levels are elevated in familial C4b-binding protein deficiency
    P C Comp
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104
    Blood 76:2527-9. 1990
    In plasma, 40% of the protein S is free and functions as a cofactor for the anticoagulant effects of activated protein C. The remaining 60% of protein S is complexed to C4b-binding protein and is functionally inactive...

Research Grants16

  1. Thrombus Formation and Antithrombotic Intervention
    John H Griffin; Fiscal Year: 2013
    ..Project 1 (Griffin: Murine protein C and protein S proof of principle research) will focus on the initiation of signaling by activated protein C (APC) via apoER2 ..
  2. ONTOGENY OF THE PROTEIN C SYSTEM
    Marilyn Manco Johnson; Fiscal Year: 1992
    ..differ from results found in the neonatal lamb or the mature sheep? 2) When in gestation are PC and its cofactor protein S (PS) expressed in fetal ovine plasma? 3) What is the developmental rate of rise of these proteins? 4) Is the ..
  3. Structure:function studies of the glucocorticoid receptor
    Raj Kumar; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. Novel Anticoagulant Mechanisms
    MARY HEEB; Fiscal Year: 2006
    ..We will find whether a ZPI polymorphism we identified affects function. ..
  5. FORMS OF PROSTATE SPECIFIC ANTIGEN AND HK2 IN CANCER
    MARY HEEB; Fiscal Year: 2003
    ..Techniques will include protein purification, antibody and ELISA development, immunoblotting, enzyme activity assays, and peptide synthesis. ..
  6. Novel targets and agents to treat thrombotic disorders
    John Griffin; Fiscal Year: 2004
    ..abstract_text> ..
  7. Pathophysiologies Involving Hemostasis-related Genes
    Francis Castellino; Fiscal Year: 2008
    ..abstract_text> ..
  8. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  9. Structure-based In silico Screen for Small Molecule Inhibitors of Ets-1 Activity
    Alan Rigby; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. THROMBOMODULIN FUNCTION IN CELLULAR PHYSIOLOGY
    Hartmut Weiler; Fiscal Year: 2007
    ..abstract_text> ..
  11. AIDS ASSOCIATED MALIGNANCIES CLINICAL TRIALS CONSORTIUM
    Alexandra Levine; Fiscal Year: 2005
    ..The expertise of our labs and experience will be available to the AMC, which will be considered of the highest priority for our Group. ..
  12. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
  13. Gas6/Mertk mediated phagocytosis of OS by RPE cells
    Michael Hall; Fiscal Year: 2005
    ..abstract_text> ..
  14. Stabilized factor VIIIa as improved therapy for hemophilia A
    ANDREW GALE; Fiscal Year: 2008
    ..This treatment could improve the quality of life and overall health of the hemophilia A sufferers. ..
  15. Structure/Function Study of the Anticoagulant Protein S
    Alan Rigby; Fiscal Year: 2005
    ..mechanism for regulating thrombin formation, whereby activated protein C (APC) in association with its cofactor protein S enhances the inactivation of factor Va (FVa) and factor VIIIa (FVIIIa)...
  16. PDE3 Inhibitors: Selective Blockers of Oocyte Maturation
    Jeffrey Jensen; Fiscal Year: 2007
    ..This approach is expected to provide a foundation for future Phase 1 trials of PDE3 inhibitors in humans. ..