fibrin fibrinogen degradation products

Summary

Summary: Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.

Top Publications

  1. ncbi Does this patient have deep vein thrombosis?
    Philip S Wells
    Department of Medicine, University of Ottawa, Ontario
    JAMA 295:199-207. 2006
  2. ncbi Cross-talk between inflammation,coagulation/fibrinolysis and vascular access in hemodialysis patients
    E Costa
    Instituto de Ciências da Saúde da Universidade Católica Portuguesa, Porto, Portugal
    J Vasc Access 9:248-53. 2008
  3. ncbi Multidetector-row computed tomography in suspected pulmonary embolism
    Arnaud Perrier
    Service of General Internal Medicine, Geneva Faculty of Medicine and Geneva University Hospital, Geneva, Switzerland
    N Engl J Med 352:1760-8. 2005
  4. ncbi Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer
    P S Wells
    Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
    Ann Intern Med 135:98-107. 2001
  5. ncbi D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study
    John E Rectenwald
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Thromb Haemost 94:1312-7. 2005
  6. ncbi Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 91:812-8. 2004
  7. doi Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial
    Dan Atar
    Division of Cardiology and Faculty of Medicine, Aker University Hospital, University of Oslo, Oslo, Norway
    J Am Coll Cardiol 53:720-9. 2009
  8. doi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
  9. ncbi Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing
    Ruud Oudega
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 94:200-5. 2005
  10. pmc Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
    Luc Y Dirix
    Oncology Center, AZ St Augustinus Oosterveldlaan 24, 2610 Wilrijk, Belgium
    Br J Cancer 86:389-95. 2002

Research Grants

Detail Information

Publications286 found, 100 shown here

  1. ncbi Does this patient have deep vein thrombosis?
    Philip S Wells
    Department of Medicine, University of Ottawa, Ontario
    JAMA 295:199-207. 2006
    ..Missed DVT diagnosis may result in fatal pulmonary embolism. Since many patients may have DVT, a selective and efficient diagnostic process is needed...
  2. ncbi Cross-talk between inflammation,coagulation/fibrinolysis and vascular access in hemodialysis patients
    E Costa
    Instituto de Ciências da Saúde da Universidade Católica Portuguesa, Porto, Portugal
    J Vasc Access 9:248-53. 2008
    ..The increased levels of Ddimer, tPA and inflammatory markers in CKD patients using a CVC, led us to propose a relationship between the type of VA chosen for HD, and the risk of thrombogenesis...
  3. ncbi Multidetector-row computed tomography in suspected pulmonary embolism
    Arnaud Perrier
    Service of General Internal Medicine, Geneva Faculty of Medicine and Geneva University Hospital, Geneva, Switzerland
    N Engl J Med 352:1760-8. 2005
    ..We evaluated whether the use of D-dimer measurement and multidetector-row CT, without lower-limb ultrasonography, might safely rule out pulmonary embolism...
  4. ncbi Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer
    P S Wells
    Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
    Ann Intern Med 135:98-107. 2001
    ..5% (CI, 99.1% to 100%). CONCLUSION: Managing patients for suspected pulmonary embolism on the basis of pretest probability and D -dimer result is safe and decreases the need for diagnostic imaging...
  5. ncbi D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study
    John E Rectenwald
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Thromb Haemost 94:1312-7. 2005
    ..However for clinical applicability, the sensitivity/specificity will need to be improved. These studies also suggest the importance of soluble P-selectin in assessing DVT in humans...
  6. ncbi Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 91:812-8. 2004
    ..The present data on the distribution of values may provide a basis for the selection of appropriate cutoff points for assigning 2, and 3 points in the score...
  7. doi Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial
    Dan Atar
    Division of Cardiology and Faculty of Medicine, Aker University Hospital, University of Oslo, Oslo, Norway
    J Am Coll Cardiol 53:720-9. 2009
    ..The purpose of this study was to investigate whether FX06 would limit infarct size when given as an adjunct to percutaneous coronary intervention...
  8. doi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
    ..To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma...
  9. ncbi Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing
    Ruud Oudega
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 94:200-5. 2005
    ....
  10. pmc Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
    Luc Y Dirix
    Oncology Center, AZ St Augustinus Oosterveldlaan 24, 2610 Wilrijk, Belgium
    Br J Cancer 86:389-95. 2002
    ..A role of interleukin-6, by influencing both angiogenesis and haemostasis, is suggested by these observations...
  11. ncbi Fibrin D-dimer and cardiovascular risk
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    Semin Vasc Med 5:387-98. 2005
    ..Harmonization of results from different assays would increase clinical utility...
  12. ncbi Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
    ....
  13. doi Contemporary management of pulmonary embolism: the answers to ten questions
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    J Intern Med 268:218-31. 2010
    ..A critical appraisal of the contemporary management of suspected PE is given in this overview with the discussion of 10 practical questions...
  14. pmc Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis
    Henrike J Schouten
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508GA Utrecht, Netherlands
    BMJ 346:f2492. 2013
    ..To review the diagnostic accuracy of D-dimer testing in older patients (>50 years) with suspected venous thromboembolism, using conventional or age adjusted D-dimer cut-off values...
  15. doi An age-adapted approach for the use of D-dimers in the exclusion of deep venous thrombosis
    Fred J L M Haas
    Department of Clinical Chemistry, St Antonius Hospital, 3430 EM Nieuwegein, The Netherlands
    Am J Hematol 84:488-91. 2009
    ..A cut-off level of 750 microg/L for patients > or = 60 years improves the clinical performance of DD assays in combination with the PTP score without the loss of NPV. The NNT improves substantially with an age-adapted algorithm...
  16. doi Study on construction of nano tPA plasmid to prevent thrombosis after mechanical valve replacement in dogs
    Shangyi Ji
    Shenzhen Sun Yat sen Cardiovascular Hospital, Shenzhen Heart Institute, Guangdong, China
    J Surg Res 168:e1-5. 2011
    ..Mechanical valve is inclined to induce thrombosis. We intend to elucidate the transfection of nano tissue-type plasminogen activator (tPA) gene plasmid to prevent thrombosis after tricuspid mechanical valve replacement in dogs...
  17. ncbi Different cut-off values for two D-dimer assays to exclude deep venous thrombosis in primary care
    Ruud Oudega
    Thromb Haemost 95:744-6. 2006
  18. pmc Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis
    James Douketis
    St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
    BMJ 342:d813. 2011
    ..Data source Comprehensive search of electronic databases (Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials) until July 2010, supplemented by review of conference abstracts and contact with content experts...
  19. doi Elevated D-dimer levels predict recurrence in patients with idiopathic venous thromboembolism: a meta-analysis
    E Bruinstroop
    Leiden University Medical Center, Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, Leiden, The Netherlands
    J Thromb Haemost 7:611-8. 2009
    ..The evidence on the optimal duration of treatment in patients with an idiopathic venous thromboembolic event (VTE) is inconclusive. d-dimer testing to predict recurrent VTE has been evaluated in several studies...
  20. doi High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study
    M Besser
    Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK
    J Thromb Haemost 6:1720-5. 2008
    ..To determine the predictive value of measurement of parameters of thrombin generation for unprovoked recurrent venous thrombosis...
  21. doi Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism
    James Douketis
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 153:523-31. 2010
    ..However, questions remain about the utility of measuring d-dimer in clinical practice...
  22. ncbi Efficacy and safety of recombinant human activated protein C for severe sepsis
    G R Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 344:699-709. 2001
    ..In this phase 3 trial, we assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis...
  23. ncbi Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review
    M Di Nisio
    Department of Medicine and Aging, School of Medicine, and Aging Research Centre, Ce S I, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    J Thromb Haemost 5:296-304. 2007
    ..It is unknown to what extent this is due to differences in study design or patient groups, or to genuine differences between D-dimer assays...
  24. ncbi Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia
    Gualtiero Palareti
    Dipartimento di Angiologia, Unità Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Circulation 108:313-8. 2003
    ..The aim of the present study was to assess the predictive value of D-dimer for recurrent VTE in subjects with a previous unprovoked event who are either carriers of inherited thrombophilia or not...
  25. ncbi D-dimer levels and risk of recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, University of Vienna, Austria
    JAMA 290:1071-4. 2003
    ..Because of the increasing number of risk factors, assessing the risk of recurrence in an individual patient is intricate; therefore, a laboratory method that measures multifactorial thrombophilia is required...
  26. ncbi Plasma D-dimers in the diagnosis of venous thromboembolism
    James Kelly
    SpR in Elderly Care GIM, Elderly Care Dept, c o Alexandra Ward, North Wing, Ninth Floor, St Thomas Hospital, Lambeth Palace Road, Lambeth, London SE1 7EH, England
    Arch Intern Med 162:747-56. 2002
    ..If alternative assays are to be substituted, these should consistently have been shown to possess equivalent or greater sensitivity...
  27. ncbi Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis
    Philip S Wells
    Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
    N Engl J Med 349:1227-35. 2003
    ....
  28. ncbi Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
    J Allergy Clin Immunol 119:705-10. 2007
    ..In patients with chronic urticaria (CU), plasma shows signs of thrombin generation and autologous plasma skin tests score positive in as many as 95% of cases...
  29. pmc High incidence of silent venous thromboembolism before treatment in ovarian cancer
    T Satoh
    Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Br J Cancer 97:1053-7. 2007
    ..The usefulness of preoperative assessment of VTE needs further confirmation in randomised controlled trials...
  30. ncbi Diagnosing pulmonary embolism: running after the decreasing prevalence of cases among suspected patients
    G Le Gal
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    J Thromb Haemost 2:1244-6. 2004
  31. ncbi Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Thromb Haemost 83:416-20. 2000
    ..The combination of a score < or =4.0 by our simple clinical prediction rule and a negative SimpliRED D-Dimer result may safely exclude PE in a large proportion of patients with suspected PE...
  32. ncbi Combination of a normal D-dimer concentration and a non-high pretest clinical probability score is a safe strategy to exclude deep venous thrombosis
    R E G Schutgens
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Circulation 107:593-7. 2003
    ..We studied the clinical validity of the combination of a pretest clinical probability score and a D-dimer test in the initial evaluation of patients suspected of deep venous thrombosis...
  33. doi Unprovoked recurrent venous thrombosis: prediction by D-dimer and clinical risk factors
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 6:577-82. 2008
    ..The aim of the study was to determine the predictive value of D-dimer measurement for unprovoked recurrent venous thrombosis and the influence of sex, age and type of first event (unprovoked or provoked)...
  34. doi Analytical and clinical validation of a new point-of-care testing system for determination of D-Dimer in human blood
    Johannes J Sidelmann
    Department for Thrombosis Research, Institute for Public Health, University of Southern Denmark, and Department of Clinical Biochemistry, Hospital of South West Denmark, Esbjerg, Denmark
    Thromb Res 126:524-30. 2010
    ..The test is rapidly performed and the measuring range of the assay is wide. The NPV, PPV, specificity, sensitivity and AUC of AQT D-Dimer for both proximal and distal DVT are comparable to routine D-Dimer assays...
  35. ncbi Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Arch Intern Med 164:2483-7. 2004
    ....
  36. doi A new diagnostic rule for deep vein thrombosis: safety and efficiency in clinically relevant subgroups
    D B Toll
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Fam Pract 25:3-8. 2008
    ..However, the rule's 'efficiency' (proportion of patients designated by the rule as very low risk) and safety (DVT prevalence among these very low risk patients) may change according to patient characteristics...
  37. pmc Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded
    Renee A Douma
    Department of Vascular Medicine, Academic Medical Center, F4 Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Haematologica 97:1507-13. 2012
    ..We retrospectively validated the efficacy of this cut-off combined with clinical probability for the exclusion of deep vein thrombosis...
  38. ncbi The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury
    Peter Petzelbauer
    Department of General Dermatology, Medical University of Vienna, 18 20 Waehringer Guertel, Vienna, 1090, Austria
    Nat Med 11:298-304. 2005
    ..The naturally occurring peptide Bbeta15-42 represents a potential candidate for reperfusion therapy in humans...
  39. pmc Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review
    Tonya L Fancher
    Division of General Medicine, University of California at Davis, Patient Support Services Building, Suite 2400, Sacramento, California 95817, USA
    BMJ 329:821. 2004
    ..To summarise the evidence supporting the use of rapid d-dimer testing combined with estimation of clinical probability to exclude the diagnosis of deep venous thrombosis among outpatients...
  40. ncbi A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis
    Shannon M Bates
    McMaster University Medical Centre, HSC 3W11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Ann Intern Med 138:787-94. 2003
    ..Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT)...
  41. doi Clinical probability assessment and D-dimer determination in patients with suspected deep vein thrombosis, a prospective multicenter management study
    J L Elf
    Department of Emergency Medicine, Lund University, Lund University Hospital, Sweden
    Thromb Res 123:612-6. 2009
    ..To investigate the reliability of a combined strategy of clinical assessment score followed by a local D-dimer test to exclude deep vein thrombosis. For comparison D-dimer was analysed post hoc and batchwise at a coagulation laboratory...
  42. ncbi The predictive value of D-dimer measurement for cancer in patients with deep vein thrombosis
    Roger E G Schutgens
    Department of Hematology, University Hospital Utrecht, The Netherlands
    Haematologica 90:214-9. 2005
    ..The aim of this study was to evaluate the value of D-dimer concentration in predicting cancer in patients with DVT...
  43. doi Clinical decision rules for excluding pulmonary embolism: a meta-analysis
    Wim Lucassen
    Academic Medical Center, Amsterdam, University Medical Center Utrecht, The Netherlands
    Ann Intern Med 155:448-60. 2011
    ..Clinical probability assessment is combined with d-dimer testing to exclude pulmonary embolism (PE)...
  44. ncbi The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury
    Jan P Roesner
    Department of Anaesthesia, University Hospital Rostock, Germany
    Crit Care Med 35:1730-5. 2007
    ..In addition, we evaluated the pharmacokinetics and safety of Bbeta15-42 in several species, including humans...
  45. ncbi Simplification of the diagnostic management of suspected deep vein thrombosis
    Roderik A Kraaijenhagen
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arch Intern Med 162:907-11. 2002
    ..We hypothesized that a normal finding of a D-dimer assay safely obviates the need for repeated ultrasonography. In addition, we evaluated the potential value of a pretest probability assessment for this purpose...
  46. doi Patient-level compared with study-level meta-analyses demonstrate consistency of D-dimer as predictor of venous thromboembolic recurrences
    Maura Marcucci
    Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    J Clin Epidemiol 66:415-25. 2013
    ....
  47. doi Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    J Thromb Haemost 8:2436-42. 2010
    ..To determine if the mode of presentation of venous thromboembolism (VTE), as deep vein thrombosis (DVT) or pulmonary embolism (PE), predicts the likelihood and type of recurrence...
  48. ncbi Does this patient have pulmonary embolism?
    Sanjeev D Chunilal
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 290:2849-58. 2003
    ..Recent studies have shown that the combination of a low pretest probability (using a clinical prediction rule) and a normal result of a D-dimer test reliably excludes pulmonary embolism without the need for further testing...
  49. ncbi Steady-state end-tidal alveolar dead space fraction and D-dimer: bedside tests to exclude pulmonary embolism
    M A Rodger
    Department of Medicine, University of Ottawa, Ontario, Canada
    Chest 120:115-9. 2001
    ..15, (2) a negative D-dimer result, and (3) the combination of a steady-state end-tidal AVDSf of < 0.15 and a negative D-dimer result...
  50. ncbi Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped
    Gualtiero Palareti
    Department of Angiology, Unità Ricerca Clinica sulla Trombofilia M Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Haemost 87:7-12. 2002
    ..Only five idiopathic recurrences occurred in the 186 patients with consistently normal D-dimer. In conclusion, D-dimer has a high NPV for VTE recurrence when performed after OAT discontinuation...
  51. ncbi Plasma D-dimer concentrations in different clinical conditions
    K ver Elst
    Laboratorium Hematologie en Hemostase, Academisch Ziekenhuis Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussel, Belgie
    Acta Clin Belg 57:325-30. 2002
    ..Overall, we found 64% DD positivity with a median concentration of 775 micrograms/L. We found elevated DD concentrations in various clinical conditions...
  52. ncbi Laboratory markers in the diagnosis of venous thromboembolism
    Joseph A Caprini
    Department of Surgery, Evanston Northwestern Healthcare, Burch 104, 2650 Ridge Ave, Evanston, Ill 60201, USA
    Circulation 109:I4-8. 2004
    ..Often, lifelong anticoagulation may be needed as these patients and family members may need testing before taking birth control pills or hormonal replacement...
  53. ncbi Reduced efficacy of clinical probability score and D-dimer assay in elderly subjects suspected of having deep vein thrombosis
    Roger E G Schutgens
    Haematology, University Hospital Utrecht, Utrecht, The Netherlands
    Br J Haematol 129:653-7. 2005
    ..8 years) versus 25% in younger patients (P = 0.00005). We therefore conclude that the combined strategy of a low/moderate PCP score with a normal D-dimer test is safe for excluding DVT in all age groups, but is less useful in the elderly...
  54. ncbi Use of different D-dimer levels to exclude venous thromboembolism depending on clinical pretest probability
    L A Linkins
    Department of Medicine, Henderson Research Center, McMaster University, Hamilton, Canada
    J Thromb Haemost 2:1256-60. 2004
    ..Use of three pretest probability-specific D-dimer cut-off points rather than a single D-dimer cut-off point for all patients, has the potential to increase the utility of D-dimer testing for the diagnosis of venous thromboembolism...
  55. ncbi Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis
    Dimitrios Kirmizis
    Department of Nephrology, Serres General Hospital, Serres, Greece
    Med Sci Monit 12:CR55-62. 2006
    ..We designed this case-control study to investigate their validity and any differences between them...
  56. ncbi Clinical practice. The evaluation of suspected pulmonary embolism
    Peter F Fedullo
    Division of Pulmonary and Critical Care Medicine, University of California, San Diego, Medical Center, San Diego, La Jolla, CA 92037 1300, USA
    N Engl J Med 349:1247-56. 2003
  57. pmc Cost effective approach for emergency department investigation of deep vein thrombosis
    R Sinharay
    Emerg Med J 21:126. 2004
  58. ncbi Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism
    John E Schrecengost
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin Chem 49:1483-90. 2003
    ..The ability of various D-dimer assays to exclude the diagnosis of thromboembolic diseases is controversial. We examined the diagnostic accuracy of two D-dimer methods in hospitalized patients and outpatients...
  59. ncbi D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 121:1262-8. 2002
    ..To determine the relationship between d-dimer (DD) and both proinflammatory and anti-inflammatory cytokine levels, and to confirm the association between DD status and outcomes in critically ill patients...
  60. doi Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?
    Violeta Dopsaj
    Institute of Medical Biochemistry, Clinical Centre of Serbia, 11000 Belgrade, Serbia
    Blood Coagul Fibrinolysis 20:546-51. 2009
    ....
  61. ncbi Comparison of four strategies for diagnosing deep vein thrombosis: a cost-effectiveness analysis
    N Perone
    Medical Clinic 2 (NP, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Am J Med 110:33-40. 2001
    ..Serial ultrasonography is less cost-effective...
  62. doi Diagnostic accuracy and user-friendliness of 5 point-of-care D-dimer tests for the exclusion of deep vein thrombosis
    Geert Jan Geersing
    University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Chem 56:1758-66. 2010
    ..Before implementation in practice, however, the diagnostic accuracy of each test should be validated...
  63. ncbi Emergency department D-dimer testing
    A T Sadosty
    Department of Emergency Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Emerg Med 21:423-9. 2001
    ..We conclude with a discussion of the clinical utility of D-dimer in the evaluation of patients with venous thromboembolism...
  64. ncbi Management of suspected deep venous thrombosis in outpatients by using clinical assessment and D-dimer testing
    C Kearon
    McMaster University Clinic, Room 401, Henderson General Hospital, 711 Concession Street; Hamilton, Ontario L8V 1C3, Canada
    Ann Intern Med 135:108-11. 2001
    ..9% to 100%]). CONCLUSION: The combination of a low pretest probability of deep venous thrombosis and a negative result on a whole-blood D -dimer test rules out deep venous thrombosis in a large proportion of symptomatic outpatients...
  65. pmc Comparing the diagnostic performance of 2 clinical decision rules to rule out deep vein thrombosis in primary care patients
    Eit Frits van der Velde
    Department of General Practice, Vascular Medicine and Clinical Epidemiology, University of Amsterdam, The Netherlands
    Ann Fam Med 9:31-6. 2011
    ..The objective was to compare the ability of both rules to safely rule out DVT and to efficiently reduce the number of referrals for leg ultrasound investigation that would result in a negative finding...
  66. ncbi Does this patient have deep vein thrombosis?
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 279:1094-9. 1998
    ..To review the validity of the clinical assessment and diagnostic tests in patients with suspected deep vein thrombosis (DVT)...
  67. ncbi A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
    Ann Intern Med 142:490-6. 2005
    ..With suspected deep venous thrombosis and normal results on proximal vein ultrasonography, a negative d-dimer result may exclude thrombosis and a positive D-dimer result may be an indication for venography...
  68. ncbi Accuracy of D-dimer/fibrinogen ratio to predict pulmonary embolism: a prospective diagnostic study - a rebuttal
    J M Calvo-Romero
    J Thromb Haemost 2:1862-3; author reply 1863-4. 2004
  69. doi Cancer-associated ischemic stroke is associated with elevated D-dimer and fibrin degradation product levels in acute ischemic stroke with advanced cancer
    Tomoyuki Kono
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Geriatr Gerontol Int 12:468-74. 2012
    ..The aim of the present study was to elucidate the clinical characteristics of cancer-associated ischemic stroke...
  70. ncbi Locating the active site for angiogenesis and cell proliferation due to fibrin fragment E with a phage epitope display library
    C M Stirk
    Department of Pathology, University of Aberdeen Medical School, Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK
    Gen Pharmacol 35:261-7. 2000
    ..Such peptide information has therapeutic potential for both stimulating and suppressing angiogenesis and cell proliferation...
  71. ncbi Validation, calibration, and specificity of quantitative D-dimer assays
    Carl Erik Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Semin Vasc Med 5:315-20. 2005
    ..Assay technologies include manual latex agglutination assays, automated latex-enhanced light-scattering immunoassays, enzyme-linked immunoassays, and others...
  72. doi The importance of clinical probability assessment in interpreting a normal d-dimer in patients with suspected pulmonary embolism
    Nadine S Gibson
    Department of Vascular Medicine, Academical Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Chest 134:789-93. 2008
    ..The objective of this study was to investigate how often the d-dimer test fails when clinical probability is not taken into account...
  73. doi Evaluation of soluble fibrin and D-dimer in the diagnosis of postoperative deep vein thrombosis
    Rui Niimi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    Biomarkers 15:149-57. 2010
    ..Although the SF and D-dimer tests cannot be used as stand-alone tests, SF and D-dimer are valuable screening tools. We recommend two-stage screening including first with the SF or D-dimer test, followed by ultrasonography or venography...
  74. ncbi Dose response of intravenous heparin on markers of thrombosis during primary total hip replacement
    N E Sharrock
    Department of Anesthesiology, The Hospital for Special Surgery, Cornell University Medical College, New York, New York 10021, USA
    Anesthesiology 90:981-7. 1999
    ..This study assesses the effect of two doses of unfractionated intravenous heparin administered before femoral preparation during THR on circulating markers of thrombosis...
  75. doi Further validation and simplification of the Wells clinical decision rule in pulmonary embolism
    Nadine S Gibson
    Department of Vascular Medicine, Academical Medical Center, Meibergdreef 9, 1105 AZ Amsterdam
    Thromb Haemost 99:229-34. 2008
    ..This study further validates the diagnostic utility of the Wells rule and indicates that the scoring system can be simplified to one point for each variable...
  76. doi Implementation of a rapid whole blood D-dimer test in the emergency department of an urban academic medical center: impact on ED length of stay and ancillary test utilization
    Elizabeth Lee-Lewandrowski
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Clin Pathol 132:326-31. 2009
    ..The rapid D-dimer test was associated with a shorter ED LOS and fewer hospital admissions...
  77. doi Performance of age-adjusted D-dimer cut-off to rule out pulmonary embolism
    A Penaloza
    Emergency Department, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    J Thromb Haemost 10:1291-6. 2012
    ..Age-adjusted D-dimer cut-off has recently been proposed to increase D-dimer usefulness in older patients suspected of pulmonary embolism (PE)...
  78. doi Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery
    Akihiro Sudo
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Hematol 89:572-6. 2009
    ..6 microg/ml of SF at day 1 after surgery, or less than 7.0 microg/ml of D-dimer at day 4 excluded DVT. These findings suggest that the D-dimer and SF are useful for the diagnosis and exclusion of DVT after orthopaedic surgery...
  79. doi Can D-dimer become a new diagnostic parameter for acute appendicitis?
    Oner Mentes
    Department of General Surgery, Gulhane Military School of Medicine, Etlik Ankara 06018, Turkey
    Am J Emerg Med 27:765-9. 2009
    ..In this study, we investigated D-dimer serum level as a diagnostic parameter for acute appendicitis...
  80. doi The combination of four different clinical decision rules and an age-adjusted D-dimer cut-off increases the number of patients in whom acute pulmonary embolism can safely be excluded
    Josien van Es
    Vascular Medicine, Amsterdam Medical Center, AMC F4 142 Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Thromb Haemost 107:167-71. 2012
    ..The number of VTE failures was also comparable in all CDRs. In conclusion, irrespective of which CDR is used, the age-adjusted D-dimer substantially increases the number of patients above 50 years in whom PE can be safely excluded...
  81. ncbi [Parameters related to fibrinolysis and their meanings]
    Tetsumei Urano
    Department of Physiology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Rinsho Byori 59:703-8. 2011
    ..These assay methods are described together with underlying molecular mechanisms at each step of fibrinolytic system...
  82. ncbi Crystal structure of fragment double-D from human fibrin with two different bound ligands
    S J Everse
    Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    Biochemistry 37:8637-42. 1998
    ..Additionally, we have found that the beta-chain domain, like its gamma-chain counterpart, binds calcium...
  83. ncbi The value of D-dimer test in the diagnosis of patients with nontraumatic acute abdomen
    Hizir Yakup Akyildiz
    Department of General Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey
    Ulus Travma Acil Cerrahi Derg 16:22-6. 2010
    ..In these patients, it is very important to distinguish between surgical and nonsurgical pathology. Our aim was to compare the accuracy of the leukocyte count and D-dimer test in the diagnosis of acute abdomen...
  84. ncbi D-dimer in the early diagnosis of acute mesenteric ischemia secondary to arterial occlusion in rats
    Y Kurt
    Department of General Surgery, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey
    Eur Surg Res 37:216-9. 2005
    ....
  85. pmc Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis
    Henrike J Schouten
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, Netherlands
    BMJ 344:e2985. 2012
    ..To determine whether the use of age adapted D-dimer cut-off values can be translated to primary care patients who are suspected of deep vein thrombosis...
  86. doi European and American suspected and confirmed pulmonary embolism populations: comparison and analysis
    A Penaloza
    Emergency Department, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Belgium, France
    J Thromb Haemost 10:375-81. 2012
    ..If the prevalence of pulmonary embolism (PE) differs significantly between the US and Europe, this observation could reduce the generalizability of diagnostic protocols for PE derived in either location...
  87. doi Relation between D-dimer level, venous valvular reflux and the development of post-thrombotic syndrome after deep vein thrombosis
    J Latella
    Department of Medicine, McGill University, Montreal, Canada
    J Thromb Haemost 8:2169-75. 2010
    ..The pathophysiology of post-thrombotic syndrome (PTS) is postulated to involve persistent venous obstruction and venous valvular reflux...
  88. doi Current approach to the diagnosis of acute nonmassive pulmonary embolism
    Lisa K Moores
    Department of Medicine, The Uniformed Services University of the Health Sciences, Office for Student Affairs, Bethesda, MD 20814, USA
    Chest 140:509-18. 2011
    ..A completely noninvasive diagnostic algorithm for patients presenting with suspected acute pulmonary embolism is proposed...
  89. doi Inappropriate use of D-dimer assay and pulmonary CT angiography in the evaluation of suspected acute pulmonary embolism
    Fang Yin
    Good Samaritan Hospital of Maryland, Baltimore, USA
    Am J Med Qual 27:74-9. 2012
    ..This result suggests that d-dimer assay and CTA are used inappropriately to evaluate patients with suspected acute PE in our ED. The low threshold for initiating an evaluation for PE decreases the prevalence of PE in this population...
  90. ncbi Accuracy of D-dimer/fibrinogen ratio to predict pulmonary embolism: a prospective diagnostic study
    N Kucher
    Cardiology, Swiss Cardiovascular Center Bern, Department of Emergency Medicine, University Hospital Bern, Bern, Switzerland
    J Thromb Haemost 1:708-13. 2003
    ..D/F ratio >103 is highly specific for the presence of acute PE, and causes a doubling of the diagnostic rate compared with d-dimer testing alone...
  91. doi D-dimers and efficacy of clinical risk estimation algorithms: sensitivity in evaluation of acute pulmonary embolism
    Rajan T Gupta
    Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710, USA
    AJR Am J Roentgenol 193:425-30. 2009
    ..The goal of this study was to test the efficacy of clinical risk algorithms and a quantitative immunoturbidimetric D-dimer assay in the evaluation of patients undergoing pulmonary CT angiography for suspected acute pulmonary embolism...
  92. ncbi Comparison of general and spinal anesthesia and their influence on hemostatic markers in patients undergoing total hip arthroplasty
    Sabine Brueckner
    Department of Anesthesiology, Department of Internal Medicine, Subdivision of Hemostaseology, University of Luebeck, Ratzeburger Allee 160, D 23528 Luebeck, Germany
    J Clin Anesth 15:433-40. 2003
    ..To evaluate the profile of molecular hemostatic markers in patients receiving either spinal or balanced general anesthesia for total hip arthroplasty...
  93. ncbi D-dimer in venous thromboembolism
    Paula Bockenstedt
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical Center, Ann Arbor, USA
    N Engl J Med 349:1203-4. 2003
  94. ncbi Comparison of the diagnostic performance of three soluble fibrin monomer tests and a D-dimer assay in patients with clinically suspected deep vein thrombosis of the lower limbs
    Antoine Elias
    Haematologica 89:499-501. 2004
    ..Thrombosis was confirmed or excluded by complete lower-limb ultrasound. SFM assay were less accurate than VIDAS D-dimer and in patients with small thrombosis or under anticoagulation. Specificity was lower for a similar sensitivity...
  95. ncbi Pulmonary embolism: accuracy and safety of a negative CT pulmonary angiogram and value of a negative D-dimer assay to exclude CT pulmonary angiogram-detectable pulmonary embolism
    R M Subramaniam
    Department of Radiology, Waikato Clinical School, University of Auckland, Hamilton, New Zealand
    Australas Radiol 50:424-8. 2006
    ..Negative Simplify D-dimer assay and low pretest clinical probability exclude CTPA-detectable PE, and a CTPA is unnecessary in this cohort of patients...
  96. ncbi D-dimer local expression is increased in symptomatic patients undergoing carotid endarterectomy
    Jerzy Krupinski
    Cardiovascular Research Center, IIBB CSIC HSCSP UAB, Barcelona, Spain
    Int J Cardiol 116:174-9. 2007
    ..We hypothesized that symptomatic patients with advanced, unstable carotid plaques have increased local intraplaque and circulating levels of fibrin-fibrinogen related products...
  97. ncbi Non-overt disseminated intravascular coagulation scoring for critically ill patients: the impact of antithrombin levels
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan
    Thromb Haemost 101:696-705. 2009
    ..When information on AT levels was included, non-overt DIC scoring was found to predict development of overt-DIC significantly earlier than non-overt DIC scoring without AT...
  98. ncbi Evaluation and management of the acutely dyspneic patient: the role of biomarkers
    Alex Harrison
    Division of Medical Education and General Internal Medicine, Scripps Mercy Hospital, San Diego, CA 92103, USA
    Am J Emerg Med 23:371-8. 2005
    ..If a PE, AMI, or CHF is determined to be the cause of dyspnea, a biomarker panel could help risk stratify and help determine initial therapies. Subsequent clinical research is needed to corroborate this postulation...
  99. doi Are fibrin-related markers useful for the diagnosis of thrombosis?
    Hideo Wada
    Departments of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan
    Semin Thromb Hemost 34:33-8. 2008
    ..Overall, elevated levels of FRMs indicate a high risk for thrombosis, and they are thus considered to be useful for the diagnosis of thrombosis...
  100. ncbi D-dimer is useful in the diagnosis of cortical venous sinus thrombosis
    Usha K Misra
    Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India
    Neurol India 57:50-4. 2009
    ..Estimations of D-dimer correlate with deep vein thrombosis and pulmonary thromboembolism and may serve as a marker of cortical venous sinus thrombosis (CVST)...
  101. ncbi D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism
    S Shrivastava
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
    J Thromb Haemost 4:1208-14. 2006
    ..Elevated plasma D-dimer and factor VIII coagulant activity (FVIIIc) may be associated with the risk of recurrent venous thromboembolism (VTE)...

Research Grants42

  1. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
  2. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  3. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2008
    ..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
  4. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  5. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  6. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  7. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  8. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  9. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  10. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  11. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..4) The team of investigators is strong, and has collaborated previously in successful research in PE. ..
  12. Prospective Investigation for Pulmonary Embolism Dx III
    Paul Stein; Fiscal Year: 2008
    ..abstract_text> ..
  13. Characterization of the flexible portions of fibrinogen
    Russell Doolittle; Fiscal Year: 2007
    ..These studies are aimed at determining the degree of specificity involved in the assembly of fibrin units and protofibrils as well as the relative locations of the regions involved. ..
  14. MANAGEMENT OF PATIENTS WITH SUSPECTED PULMONARY EMBOLISH
    Suman Rathbun; Fiscal Year: 2005
    ..abstract_text> ..
  15. STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRIN
    Russell Doolittle; Fiscal Year: 2003
    ..Combined with the full structures of the native molecules at high resolution, these results should dispel much of the mystery of fibrin formation. ..
  16. Pleasant Events and Moods: A Time-Series Analysis
    Brent Mausbach; Fiscal Year: 2006
    ..The remaining participants will receive no feedback. All participants will receive a one-month follow-up to determine if those receiving detailed feedback experience fewer negative emotions and more positive emotions. ..
  17. Antiestrogenic Effects on Tumor Angiogenesis
    Kimberly Blackwell; Fiscal Year: 2006
    ..The results of this project will have profound implications, especially as clinicians begin to use the newer estrogen receptor modulating drugs for the prevention and treatment of breast cancer. ..
  18. UCSD Hillcrest Flow Cytometer
    Paul Mills; Fiscal Year: 2003
    ..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
  19. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul J Mills; Fiscal Year: 2010
    ..abstract_text> ..
  20. COAGULATION ACTIVATION IN SICKLE CELL DISEASE
    Kenneth I Ataga; Fiscal Year: 2010
    ..abstract_text> ..
  21. Thrombospondins and Atherothrombosis
    Edward Plow; Fiscal Year: 2004
    ..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
  22. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
  23. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
  24. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  25. Treatment of Hyperglycemia Ischemic Stroke(THIS)Trial
    Askiel Bruno; Fiscal Year: 2004
    ..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months. ..
  26. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  27. LEUKOCYTE INTEGRIN ALPHA M BETA 2
    Edward Plow; Fiscal Year: 2004
    ....
  28. CYTOKINE BALANCE IN VENOUS THROMBOSIS
    Thomas Wakefield; Fiscal Year: 2002
    ..abstract_text> ..
  29. Pathogenesis of SIV in African green monkeys
    Ivona Pandrea; Fiscal Year: 2010
    ..Combined, these aims are designed to determine the viral and/or host factors responsible for resistance to AIDS. ..
  30. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2011
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
  31. MEDIATORS OF AGE ASSOCIATED OUTCOMES IN HIV INFECTION
    Amy Justice; Fiscal Year: 2002
    ..By virtue of the requested support, the applicant believes she will gain the experience and insight needed to conduct multidisciplinary interventional studies to improve outcomes for middle-aged and older people with HIV. ..
  32. 2004 Hemostasis Gordon Research Conference
    Edward Plow; Fiscal Year: 2004
    ..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
  33. THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIA
    Edward Plow; Fiscal Year: 2003
    ..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
  34. SAFER THROMBOLYTIC THERAPY USING PLASMIN
    Victor Marder; Fiscal Year: 2007
    ..We hypothesize and anticipate that plasmin will provide clinically effective thrombolysis without an increased risk of bleeding . ..
  35. Immune Thrombocytopenia and Low-Level Mercury Exposure
    Jodi Segal; Fiscal Year: 2006
    ..Segal with the necessary support for successful completion [unreadable] [unreadable] [unreadable]..
  36. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..e., is the "hypercoagulability" observed in patients with SCD a primary cause of the vasoocclusion or is it simply a secondary event that is observed in this clinical setting. ..
  37. Alcohol Associated Outcomes Among HIV+/-Aging Veterans
    Amy Justice; Fiscal Year: 2002
    ..After completing baseline enrollment, follow up will occur at 6-month intervals and new patients will be enrolled as they present for care. ..
  38. Chronic Thromboembolic Pulmonary Hypertension
    TIMOTHY MORRIS; Fiscal Year: 2006
    ..The fragments will be subjected to liquid chromatography-mass spectroscopy with data-dependent MS-2 data acquisition, followed by computer-assisted sequence analysis. ..
  39. Manufacturing Process for Albumin-ICG Solder & Denatured Albumin Scaffold
    Yasmin Wadia; Fiscal Year: 2006
    ..3) Blood conservation by reducing transfusion requirements. 4) Can be used laparoscopically for elective surgeries on liver and kidney. [unreadable] [unreadable]..
  40. Pretest probability assesment and D-dimer testing for pulmonary embolism
    D Courtney; Fiscal Year: 2008
    ..He has significant experience in mentoring junior investigators and an emphasis in disease detection and outcome prediction to ensure development of the PI toward that of an independently funded investigator. ..
  41. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..