fibrinogen

Summary

Summary: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

Top Publications

  1. doi Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus
    Takehisa Ohbayashi
    Department of Oral and Maxillo Facial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Microbiology 157:786-92. 2011
  2. ncbi Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination
    David M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med 114:758-62. 2003
  3. ncbi Fibrinogen and fibrin structure and functions
    M W Mosesson
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 3:1894-904. 2005
  4. pmc Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease
    Annelyse Duvoix
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, UK
    Thorax 68:670-6. 2013
  5. ncbi Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    P M Ridker
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 285:2481-5. 2001
  6. ncbi Wound-healing defects in mice lacking fibrinogen
    A F Drew
    Division of Developmental Biology, Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, PH 45229 3039, USA
    Blood 97:3691-8. 2001
  7. doi An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease
    David A Lomas
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    J Clin Pharmacol 52:416-24. 2012
  8. pmc Anopheles fibrinogen-related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 284:9835-44. 2009
  9. ncbi Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen
    Lars Alfredsson
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 28:238-48. 2002
  10. ncbi Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels
    J A Wedzicha
    Department of Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    Thromb Haemost 84:210-5. 2000

Detail Information

Publications437 found, 100 shown here

  1. doi Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus
    Takehisa Ohbayashi
    Department of Oral and Maxillo Facial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Microbiology 157:786-92. 2011
    ..Staphopains also prolonged the thrombin time of both plasma and fibrinogen, indicating that these enzymes can cause impaired plasma clotting through fibrinogen degradation...
  2. ncbi Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination
    David M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med 114:758-62. 2003
  3. ncbi Fibrinogen and fibrin structure and functions
    M W Mosesson
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 3:1894-904. 2005
    b>Fibrinogen molecules are comprised of two sets of disulfide-bridged Aalpha-, Bbeta-, and gamma-chains. Each molecule contains two outer D domains connected to a central E domain by a coiled-coil segment...
  4. pmc Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease
    Annelyse Duvoix
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, UK
    Thorax 68:670-6. 2013
    ..b>Fibrinogen is an acute phase plasma protein that has emerged as a promising biomarker in COPD...
  5. ncbi Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    P M Ridker
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 285:2481-5. 2001
    ..Several novel risk factors for atherosclerosis have recently been proposed, but few comparative data exist to guide clinical use of these emerging biomarkers...
  6. ncbi Wound-healing defects in mice lacking fibrinogen
    A F Drew
    Division of Developmental Biology, Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, PH 45229 3039, USA
    Blood 97:3691-8. 2001
    ..To test directly these concepts, the effect of fibrinogen deficiency on cutaneous tissue repair in mice was investigated using incisional and excisional wounds...
  7. doi An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease
    David A Lomas
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    J Clin Pharmacol 52:416-24. 2012
    ..Losmapimod was well tolerated and reduced plasma fibrinogen by 11% (-0.4 g/L, ratio of effect of losmapimod/placebo 0.89; 95% confidence interval, 0.83-0.96; P = ...
  8. pmc Anopheles fibrinogen-related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 284:9835-44. 2009
    The fibrinogen-related protein family (FREP, also known as FBN) is an evolutionarily conserved immune gene family found in mammals and invertebrates...
  9. ncbi Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen
    Lars Alfredsson
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 28:238-48. 2002
    ..The aim of this study was to analyze the relationship of job strain (high psychological job demands and low decision latitude) to hypertension, serum lipids, and plasmafibrinogen...
  10. ncbi Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels
    J A Wedzicha
    Department of Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    Thromb Haemost 84:210-5. 2000
    ..We hypothesized that transient acute increases in plasma fibrinogen, an independent risk factor for CHD, could occur at COPD exacerbation (mediated through a rise in IL6) and ..
  11. doi Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial
    Paul M Ridker
    MPH, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Circulation 126:2739-48. 2012
    ..hypothesis of atherothrombosis, an agent is needed that reduces inflammatory biomarkers such as C-reactive protein, interleukin-6, and fibrinogen but that does not have major effects on lipid pathways associated with disease progression.
  12. doi The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity
    Henrik Watz
    Pulmonary Research Institute, Center for Pneumology and Thoracic Surgery, Hospital Grosshansdorf, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Chest 136:1039-46. 2009
    ..Here, we studied the following: (1) the frequency of the coexisting metabolic syndrome in patients with chronic bronchitis (CB) and COPD of different severities; and (2) its association with systemic inflammation and physical inactivity...
  13. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  14. ncbi A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin
    M Matsushita
    Department of Biochemistry, Fukushima Medical College, Japan
    J Biol Chem 271:2448-54. 1996
    ..amino acid sequence of 313 residues revealed that the mature form of P35 consists mainly of collagen- and fibrinogen-like domains...
  15. pmc Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor
    Jeremy Sokolove
    Stanford University School of Medicine, Stanford, California, USA
    Arthritis Rheum 63:53-62. 2011
    ..Nearly two-thirds of patients with ACPA-positive RA have immune complexes that contain citrullinated fibrinogen, and these citrullinated fibrinogen-containing immune complexes (cFb-IC) can exacerbate disease in murine models ..
  16. pmc Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
    Yok Ai Que
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    J Exp Med 201:1627-35. 2005
    ..This reflected the capacity of FnBPA to trigger cell internalization in vitro. Because FnBPA carries both fibrinogen- and fibronectin-binding domains, we tested the role of these functionalities by deleting the fibrinogen-binding ..
  17. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
    Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD)...
  18. pmc Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway
    Berta Vidal
    Program on Differentiation and Cancer, Center for Genomic Regulation CRG, Pompeu Fabra University UPF, E 08003 Barcelona, Spain
    Genes Dev 22:1747-52. 2008
    ..Here, we show that fibrinogen accumulates in dystrophic muscles of DMD patients and mdx mice...
  19. pmc Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3
    Timothy A Springer
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 182:791-800. 2008
    Hemostasis and thrombosis (blood clotting) involve fibrinogen binding to integrin alpha(IIb)beta(3) on platelets, resulting in platelet aggregation...
  20. doi Relation between C-reactive protein, homocysteine levels, fibrinogen, and lipoprotein levels and leukocyte and platelet counts, and 10-year risk for cardiovascular disease among healthy adults in the USA
    Chan Seok Park
    Division of Cardiology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Am J Cardiol 105:1284-8. 2010
    ..01, p <0.0001; >10.0 mg/L: OR 1.41, 95% CI 1.03 to 1.93, p = 0.034). The high-risk group had circulating fibrinogen, homocysteine, leukocyte, and platelet levels that were 20.98 mg/dl (95% CI 12.53 to 29.43, p <0.0001), 1...
  21. pmc Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
    Dimitrios Davalos
    Gladstone Institute of Neurological Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Nat Commun 3:1227. 2012
    ..Here we show that the blood protein fibrinogen induces rapid microglial responses toward the vasculature and is required for axonal damage in neuroinflammation...
  22. pmc Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4
    Valentine Ongeri Millien
    Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX, USA
    Science 341:792-6. 2013
    ..These outcomes were induced by proteinase cleavage of the clotting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway epithelial cells and macrophages...
  23. doi Genetic variation in fibrinogen; its relationship to fibrinogen levels and the risk of myocardial infarction and ischemic stroke
    B Siegerink
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    J Thromb Haemost 7:385-90. 2009
    ..by common causes and reverse causation have been proposed as explanations for the association between high fibrinogen levels and cardiovascular disease...
  24. ncbi Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: functional consequences
    Pawel Nowak
    Department of General Biochemistry, University of Lodz, Banacha 12 16 Street, 90 237 Lodz, Poland
    Thromb Res 121:163-74. 2007
    Based on previous studies suggesting that fibrinogen (Fg) might be a potential target for peroxynitrite (PN) action in plasma, we investigated the effects of PN on structure and hemostatic function of Fg in vitro...
  25. pmc MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes
    Matthias Brock
    Center of Experimental Rheumatology, University Zurich, Switzerland
    J Biol Chem 286:40142-50. 2011
    ..of transcription 3), which rapidly induces the production of acute-phase proteins such as haptoglobin and fibrinogen. Another target of the IL-6/STAT3 signal transduction pathway is the microRNA cluster miR-17/92...
  26. pmc Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen
    Aaron M S Thompson
    Gage Occupational and Environmental Health Unit, University of Toronto, Ontario, Canada
    Environ Health Perspect 118:120-4. 2010
    ..Interleukin-6 (IL-6) and fibrinogen are biomarkers of systemic inflammation that are independent risk factors for cardio-vascular disease.
  27. ncbi Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release
    S Sehgal
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Thromb Haemost 5:2009-16. 2007
    von Willebrand factor (VWF) and fibrinogen are major storage proteins of platelet alpha-granules. VWF is synthesized by the megakaryocyte, the cell from which platelets bud, and fibrinogen is delivered to alpha-granules by endocytosis.
  28. pmc Subdomains N2N3 of fibronectin binding protein A mediate Staphylococcus aureus biofilm formation and adherence to fibrinogen using distinct mechanisms
    Joan A Geoghegan
    Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin, Ireland
    J Bacteriol 195:2675-83. 2013
    ..Zn(2+), while the removal of Zn(2+) had no effect on the ability of FnBPA to mediate bacterial adherence to fibrinogen. We also investigated the role of FnBPA expressed on the surface of S...
  29. pmc Binding of glycoprotein Srr1 of Streptococcus agalactiae to fibrinogen promotes attachment to brain endothelium and the development of meningitis
    Ho Seong Seo
    Division of Infectious Diseases, Veterans Affairs Medical Center and the University of California, San Francisco, California, United States of America
    PLoS Pathog 8:e1002947. 2012
    ..Srr1 contributes to GBS attachment to hBMEC via the direct interaction of its binding region (BR) with human fibrinogen. When assessed by Far Western blotting, Srr1 was the only protein in GBS extracts that bound fibrinogen...
  30. ncbi M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
    Heiko Herwald
    Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
    Cell 116:367-79. 2004
    ..Here we find that M protein, released from the streptococcal surface, forms complexes with fibrinogen, which by binding to beta2 integrins of neutrophils, activate these cells...
  31. ncbi Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease
    M Dahl
    Department of Clinical Biochemistry, Herlev and Copenhagen University Hospitals, Copenhagen, Denmark
    Am J Respir Crit Care Med 164:1008-11. 2001
    We tested whether increased concentrations of the acute-phase reactant fibrinogen correlate with pulmonary function and rate of chronic obstructive pulmonary disease (COPD) hospitalization...
  32. ncbi The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth
    Nobuaki Akakura
    Department of Dermatology, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Cancer Res 66:9691-7. 2006
    b>Fibrinogen is a major plasma protein (350 kDa) that induces proliferative signals by serving as a scaffold to support the binding of growth factors and to promote the cellular responses of adhesion, proliferation, and migration during ..
  33. doi Fibrinogen, fibrin, and FDP induce C-reactive protein generation in rat vascular smooth muscle cells: pro-inflammatory effect on atherosclerosis
    Fang Guo
    Department of Pharmacology, Xi an Jiaotong University School of Medicine, People s Republic of China
    Biochem Biophys Res Commun 390:942-6. 2009
    ..But, it is unknown whether fibrinogen exerts a pro-inflammatory effect on vascular smooth muscle cells (VSMCs)...
  34. ncbi Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial
    Keren Shapira-Schweitzer
    Faculty of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Acta Biomater 3:33-41. 2007
    ..A novel biomaterial technology using PEGylated fibrinogen has been developed with controllable physicochemical properties based on the poly(ethylene glycol) (PEG) ..
  35. pmc Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 118:1934-42. 2011
    ..we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels of fibrinogen (Fg)α, Fgβ, and Fgγ chains significantly increase in the kidney and remain elevated throughout the ..
  36. doi Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    A Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574 Japan
    Gut 58:550-9. 2009
    ..Recent studies have shown strong expression of fibrinogen, the central protein in the haemostasis pathway, in the stromal tissues of pancreatic cancer and chronic ..
  37. doi A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease
    Hong Ren Yu
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taiwan
    Pediatr Allergy Immunol 20:699-707. 2009
    ..Differential protein displays between KD patients and febrile controls were determined. Fibrinogen beta and gamma chains, alpha-1-antitrypsin (A1AT), CD5 antigen-like precursor (CD5L), and clusterin were ..
  38. pmc Reduced bacterial adhesion to fibrinogen-coated substrates via nitric oxide release
    Gregory W Charville
    Department of Chemistry, University of North Carolina at Chapel Hill, Caudill and Kenan Laboratories, CB 3290, Chapel Hill, NC 27599 3290, USA
    Biomaterials 29:4039-44. 2008
    The ability of nitric oxide (NO)-releasing xerogels to reduce fibrinogen-mediated adhesion of Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli is described...
  39. ncbi Fibrin structure and wound healing
    N Laurens
    Department of Biomedical Research, TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    J Thromb Haemost 4:932-9. 2006
    b>Fibrinogen and fibrin play an important role in blood clotting, fibrinolysis, cellular and matrix interactions, inflammation, wound healing, angiogenesis, and neoplasia...
  40. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
    ..Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD...
  41. ncbi Fibrinogen and fibrin
    John W Weisel
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    Adv Protein Chem 70:247-99. 2005
    b>Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains linked together by 29 disulfide bonds...
  42. ncbi Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    S T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 167:2887-94. 2001
    ..Fibrin is generated from plasma-derived fibrinogen, which escapes the vasculature in response to endothelial cell retraction at sites of inflammation...
  43. ncbi Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial
    M Suckfüll
    Klinikum Grosshadern, 81377, Munchen, Germany
    Lancet 360:1811-7. 2002
    ..We aimed to determine whether acute reduction of plasma fibrinogen and serum LDL is effective for treatment of SSHL of suspected vascular origin.
  44. ncbi Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells
    Joseph S Palumbo
    Division of Hematology Oncology, Children s Hospital Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Blood 105:178-85. 2005
    ..Analyses of the distribution of radiolabeled tumor cells demonstrated that platelet function, like fibrinogen, significantly improved the survival of circulating tumor cells in the pulmonary vasculature...
  45. ncbi Fibrinogen: biochemistry, epidemiology and determinants
    S Kamath
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    QJM 96:711-29. 2003
  46. ncbi Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells
    Camie W Y Chan
    Multi Organ Transplant Program, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Immunol 170:4036-44. 2003
    b>Fibrinogen-like protein 2 (fgl2)/fibroleukin is a member of the fibrinogen-related protein superfamily. In addition to its established role in triggering thrombosis, it is known to be secreted by T cells...
  47. ncbi Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway
    Fredric Carlsson
    Department of Medical Microbiology, Dermatology and Infection, Lund University, Solvegatan 23, SE 22362 Lund, Sweden
    Mol Microbiol 56:28-39. 2005
    Human fibrinogen (Fg) binds to surface proteins expressed by many pathogenic bacteria and has been implicated in different host-pathogen interactions, but the role of bound Fg remains unclear...
  48. pmc Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis
    Natalia Wegner
    Imperial College London, London, UK
    Arthritis Rheum 62:2662-72. 2010
    ..To investigate protein citrullination by the periodontal pathogen Porphyromonas gingivalis as a potential mechanism for breaking tolerance to citrullinated proteins in rheumatoid arthritis (RA)...
  49. pmc Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage
    Christian Schachtrup
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:5843-54. 2010
    ..Here we show that the blood protein fibrinogen, which leaks into the CNS immediately after blood-brain barrier (BBB) disruption or vascular damage, serves as ..
  50. ncbi Microalbuminuria, von Willebrand factor and fibrinogen levels as markers of the severity in COPD exacerbation
    Mehmet Polatli
    Department of Pulmonology, Adnan Menderes University Hospital, Aydin, Turkey
    J Thromb Thrombolysis 26:97-102. 2008
    ..occurs, should von Willebrand Factor, a clotting factor of endothelium origin, and the plasma level of fibrinogen vary with the severity of the disease in COPD, the variability of arterial blood gas values, and the stability ..
  51. ncbi Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27,247 adults in 15 prospective studies
    Angela M Wood
    Int J Epidemiol 35:1570-8. 2006
    ..The extent of this regression dilution bias for plasma fibrinogen was investigated using repeat measurement data collected at varying time intervals on 27 247 adults in 15 ..
  52. pmc Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease
    Marta Cortes-Canteli
    Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Neuron 66:695-709. 2010
    ..Moreover, depletion of fibrinogen lessened cerebral amyloid angiopathy pathology and reduced cognitive impairment in AD mice...
  53. pmc Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
    Tsan Xiao
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 432:59-67. 2004
    ..basis for allosteric regulation of the conformation and affinity for ligand of the integrin ectodomain, and how fibrinogen-mimetic therapeutics bind to platelet integrin alpha(IIb)beta3...
  54. ncbi The structure and biological features of fibrinogen and fibrin
    M W Mosesson
    Blood Research Institute, Blood Center of Southeastern Wisconsin, P O Box 2178, Milwaukee, Wisconsin 53201, USA
    Ann N Y Acad Sci 936:11-30. 2001
    b>Fibrinogen and fibrin play important, overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, inflammation, wound healing, and neoplasia...
  55. pmc Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Crit Care 15:R83. 2011
    Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared ..
  56. pmc Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics
    Masaya Ono
    Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 284:29041-9. 2009
    ..Here, we describe successful detection of novel prolyl hydroxylation of alpha-fibrinogen using 2DICAL, based on comparison of plasma samples of 38 pancreatic cancer patients and 39 healthy subjects...
  57. pmc Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
    Crit Care 14:R55. 2010
    ..The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates...
  58. doi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  59. doi Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene
    Zhiyong Chen
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8510, Japan
    Hum Genet 128:443-52. 2010
    A deletion/insertion (Del/Ins) polymorphism of 28 base pairs (bp) in the 3' untranslated region (UTR) of fibrinogen alpha gene (FGA) was associated with thromboembolic diseases, but the underlying mechanisms remain unknown...
  60. doi Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes
    C Rourke
    Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Thromb Haemost 10:1342-51. 2012
    Low fibrinogen levels are known to occur in trauma. However, the extent of fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and association with patient outcomes remain unclear.
  61. doi Fibrinogen as a key regulator of inflammation in disease
    Dimitrios Davalos
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA
    Semin Immunopathol 34:43-62. 2012
    ..Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component...
  62. ncbi Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study
    Jan Malte Sinning
    Department of Medicine, Bundeswehrzentralkrankenhaus Koblenz, Germany
    Eur Heart J 27:2962-8. 2006
    C-reactive protein and fibrinogen have been extensively studied and shown to be predictive for a first cardiovascular event in healthy individuals...
  63. ncbi Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies
    J Danesh
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, England
    JAMA 279:1477-82. 1998
    ..A large number of epidemiologic studies have reported on associations between various "inflammatory" factors and coronary heart disease (CHD)...
  64. pmc Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
    Sibylle Kozek-Langenecker
    Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
    Crit Care 15:R239. 2011
    ..Purified human fibrinogen concentrate may offer an alternative to FFP in some instances...
  65. doi Role of relationship between HbA1c, fibrinogen and HDL-cholesterol on cardiovascular disease in patients with type 2 diabetes mellitus
    Antonio Pacilli
    Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy
    Atherosclerosis 228:247-8. 2013
    To assess the impact of relationship between glycated hemoglobin (HbA(1c)), fibrinogen and HDL-cholesterol (HDL-c) on cardiovascular disease in type 2 diabetes.
  66. ncbi Human blood plasma advanced oxidation protein products (AOPP) correlates with fibrinogen levels
    Laszlo Selmeci
    Semmelweis University, Department of Cardiovascular Surgery, Faculty of Medicine, Budapest, Hungary
    Free Radic Res 40:952-8. 2006
    ..pooled samples of human citrate-plasma or EDTA-plasma at 50 degrees C resulted in a rapid and parallel loss of fibrinogen concentration and AOPP reactivity...
  67. ncbi Polymorphism 10034C>T is located in a region regulating polyadenylation of FGG transcripts and influences the fibrinogen gamma'/gammaA mRNA ratio
    S Uitte de Willige
    Department of Hematology, Hemostasis and Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:1243-9. 2007
    b>Fibrinogen gamma haplotype 2 (FGG-H2) is associated with reduced fibrinogen gamma' levels and fibrinogen gamma'/total fibrinogen ratios and with an increased deep-venous thrombosis (DVT) risk...
  68. doi Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity
    Sheng Zheng
    Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, 5268, Remin Street, Changchun 130024, P R China
    Cancer Sci 100:859-65. 2009
    The functions of platelets and fibrinogen in protecting tumor cells from natural killer cytotoxicity have been discussed for more than 20 years. However, their exact roles and relationships in the process are still not clear...
  69. doi Fibrinogen alpha chain O-glycopeptides as possible markers of urinary tract infection
    Tiziana Pacchiarotta
    Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Proteomics 75:1067-73. 2012
    ..An unequivocal structural identification of these peptides, as O-glycosylated fragments of the human fibrinogen alpha 1 chain, required MS2 and MS3 experiments on two different MS platforms: ESI-UHR-Qq-ToF and ESI-ion trap, ..
  70. ncbi Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species
    Caryn Vadseth
    Stokes Research Institute and Department of Biochemistry and Biophysics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biol Chem 279:8820-6. 2004
    ..Here we report a selective increase in circulating levels of nitrated fibrinogen in patients with coronary artery disease...
  71. pmc Systemic inflammation in young adults is associated with abnormal lung function in middle age
    Ravi Kalhan
    Asthma Chronic Obstructive Pulmonary Disease Program, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e11431. 2010
    ..Whether systemic inflammation in healthy young adults is associated with future impairment in lung health is uncertain...
  72. ncbi Novel mfgl2 antisense plasmid inhibits murine fgl2 expression and ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice
    Chuanlong Zhu
    Laboratory of Infectious Immunology, Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hum Gene Ther 17:589-600. 2006
    Our previous reports, both experimental and human studies, have shown the importance of fibrinogen-like protein-2 (fgl2) prothrombinase in the development of fulminant viral hepatitis, a disease with a mortality of more than 80% in cases ..
  73. ncbi Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 94:3829-38. 1999
    ..Endothelial cells rendered ischemic acquire a procoagulant phenotype, characterized by fibrinogen accumulation. Therefore, we evaluated whether fibrinogen deposition during I/R mediates platelet adhesion...
  74. pmc Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont, Colchester Research Facility, Colchester, VT 05446, USA
    Circulation 124:695-703. 2011
    ....
  75. doi Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen
    Shaynoor Dramsi
    Institut Pasteur, Unité des Bactéries Pathogènes à Gram positif, 75015 Paris, France
    Microbes Infect 14:1044-8. 2012
    ..Here we show that strain NCTC10/84 used in this study is not representative for GBS isolates and question the importance of collagen as a critical extracellular matrix component for GBS infections of the central nervous system...
  76. ncbi Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke
    M Di Napoli
    Department of Neurology and Neurorehabilitation, Villa Pini d Abruzzo Care Center, Chieti, Italy
    Stroke 32:133-8. 2001
    The prognostic influences of fibrinogen and C-reactive protein (CRP) levels and their relations in ischemic stroke have not been well described...
  77. ncbi Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine
    T J Roseboom
    Department of Clinical Epidemiology, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 111:112-7. 2000
    To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5...
  78. doi Leptospira immunoglobulin-like protein B (LigB) binding to the C-terminal fibrinogen αC domain inhibits fibrin clot formation, platelet adhesion and aggregation
    Yi Pin Lin
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, NY, USA
    Mol Microbiol 79:1063-76. 2011
    ..In addition, Lig proteins are fibrinogen (Fg)-binding proteins, although the physiological role of the Lig-Fg interaction is unclear...
  79. pmc The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis
    Aydin Nazmi
    Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Room 3659, Ann Arbor, MI 48109, USA
    BMC Public Health 10:706. 2010
    ..Antibody levels of pathogens have not been examined in relation to inflammation...
  80. pmc Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization
    Hyung Jin Ahn
    Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:21812-7. 2010
    ..In the present study, we show that Aβ specifically interacts with fibrinogen with a K(d) of 26.3 ± 6...
  81. ncbi Fibrinogen mediates bladder cancer cell migration in an ICAM-1-dependent pathway
    Yann Roche
    Unité INSERM 578, Institut Albert Bonniot, Grenoble, France
    Thromb Haemost 89:1089-97. 2003
    b>Fibrinogen (fg), present in tumor matrices, has been demonstrated to be determinant in metastatic potential. We have recently shown that fg/ICAM-1 interactions are involved in leukocyte migration across endothelial cell monolayers...
  82. doi Particle and nanoparticle interactions with fibrinogen: the importance of aggregation in nanotoxicology
    Michaela Kendall
    European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, The Knowledge Spa, Truro, Cornwall
    Nanotoxicology 5:55-65. 2011
    ..inhaled or injected particles come into contact with biological fluids containing polymers, such as the protein fibrinogen. We studied interactions between well-characterized submicron particles or nanoparticles (NPs) and human ..
  83. ncbi Substitution of high monounsaturated fatty acid avocado for mixed dietary fats during an energy-restricted diet: effects on weight loss, serum lipids, fibrinogen, and vascular function
    Z Pieterse
    Potchefstroom Institute of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa
    Nutrition 21:67-75. 2005
    ..Second, we examined the effects of avocados, a rich source of monounsaturated fatty acids, as part of an energy-restricted diet on weight loss, serum lipids, fibrinogen, and vascular function in overweight and obese subjects.
  84. ncbi Transcriptional control mechanism of fibrinogen gene expression
    G M Fuller
    Department of Cell Biology, BHSB 680, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Ann N Y Acad Sci 936:469-79. 2001
    Although fibrinogen genes are expressed constitutively in hepatocytes, their transcription can be greatly increased during inflammatory stress...
  85. ncbi Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis
    Tullio Palmerini
    Department of Cardiology, Policlinico S Orsola, University of Bologna, Italy
    Eur J Cardiothorac Surg 31:685-90. 2007
    ..However, there are no data regarding the impact of C-reactive protein on mid-term mortality in patients with unprotected left main coronary artery stenosis treated with coronary artery bypass graft...
  86. ncbi Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI study
    Mary Mcgrae McDermott
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am Heart J 150:276-81. 2005
    ..To determine whether peripheral arterial disease is associated with high circulating levels of pro-inflammatory cytokines, independent of confounders...
  87. pmc Cross-sectional and longitudinal associations of neighborhood characteristics with inflammatory markers: findings from the multi-ethnic study of atherosclerosis
    Aydin Nazmi
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Health Place 16:1104-12. 2010
    ..associations of neighborhood deprivation, problems, safety, and cohesion with circulating levels of fibrinogen, interleukin-6, and C-reactive protein (n = 5370) and longitudinal associations with changes in IL-6 over a 3-4 ..
  88. pmc Fibrinogen induces endothelial cell permeability
    Neetu Tyagi
    Department of Physiology and Biophysics, Health Sciences Center, A 1115, University of Louisville, Louisville, KY 40292, USA
    Mol Cell Biochem 307:13-22. 2008
    Many cardiovascular and cerebrovascular disorders are accompanied by an increased blood content of fibrinogen (Fg), a high molecular weight plasma adhesion protein...
  89. doi Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
    Hong Yang
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Blood 114:425-36. 2009
    ..Here, we first observed that P-selectin expression was significantly decreased on platelets of fibrinogen and VWF double-deficient mice. Subsequently, we identified this was due to fibrinogen deficiency...
  90. doi UafB is a serine-rich repeat adhesin of Staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells
    Nathan P King
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Microbiology 157:1161-75. 2011
    ..The uafB mutant had a significantly reduced ability to bind to fibronectin and fibrinogen. Furthermore, we show that a recombinant protein containing the putative binding domain of UafB binds ..
  91. doi Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis
    Inga Sörensen
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Kidney Int 80:1035-44. 2011
    b>Fibrinogen plays an important role in blood coagulation but its function extends far beyond blood clotting being involved in inflammation and repair. Besides these crucial functions it can also promote tissue fibrosis...
  92. pmc Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
    Juhua Chen
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, NB50, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Blood 104:1703-10. 2004
    ..the absence of Akt-1 did not influence expression of the major platelet receptors for thrombin and collagen, fibrinogen binding in response to these agonists was significantly reduced...
  93. pmc Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection
    Kaori Sakamoto
    Department of Pathology, College of Veterinary Medicine, 501 D W Brooks Dr, University of Georgia, Athens, GA 30602 7388, USA
    Infect Immun 78:1004-11. 2010
    During inflammatory responses and wound healing, the conversion of soluble fibrinogen to fibrin, an insoluble extracellular matrix, long has been assumed to create a scaffold for the migration of leukocytes and fibroblasts...
  94. pmc Simultaneous activation of complement and coagulation by MBL-associated serine protease 2
    Anders Krarup
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 2:e623. 2007
    ..We have shown that MASP2 is capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin...
  95. pmc Inflammatory markers are increased in youth with type 1 diabetes: the SEARCH Case-Control study
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, P O Box 6511, Mail Stop A 140, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:2868-76. 2010
    ..Increased inflammation may contribute to type 1 diabetes (T1D) complications...
  96. pmc Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery
    C Solomon
    Department of Anaesthesiology and Intensive Care, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Br J Anaesth 104:555-62. 2010
    Normalization of plasma fibrinogen levels may be associated with satisfactory haemostasis and reduced bleeding...
  97. pmc Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis
    A J M Schuerwegh
    Department of Rheumatology and Pathology, and Central Medical Immunology Laboratory, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Proc Natl Acad Sci U S A 107:2586-91. 2010
    ..Moreover, these data indicate a role for IgE-ACPAs and FcepsilonRI-positive cells in the pathogenesis of RA...
  98. pmc Mechanics and contraction dynamics of single platelets and implications for clot stiffening
    Wilbur A Lam
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Nat Mater 10:61-6. 2011
    ..We find that platelets contract nearly instantaneously when activated by contact with fibrinogen and complete contraction within 15 min...
  99. pmc Fibrin(ogen) mediates acute inflammatory responses to biomaterials
    L Tang
    Division of Experimental Pathology, Albany Medical College, New York 12208
    J Exp Med 178:2147-56. 1993
    ..Rather, spontaneous adsorption of fibrinogen appears to be critical: (a) PET coated with serum or hypofibrinogenemic plasma attracts as few phagocytes as ..
  100. doi Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial
    Niels Rahe-Meyer
    Clinic for Anesthesiology and Intensive Care Medicine, Franziskus Hospital, Bielefeld, Germany
    Anesthesiology 118:40-50. 2013
    b>Fibrinogen is suggested to play an important role in managing major bleeding. However, clinical evidence regarding the effect of fibrinogen concentrate (derived from human plasma) on transfusion is limited...

Research Grants77

  1. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..bacteria;(3) evaluate the potential of applying SFS-CFI enabling technology to human plasma proteins such as fibrinogen and other components;and (4) evaluate compatibility of SFS-CFI with other enabling pathogen inactivation/ ..
  2. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum amyloid A, MMP-9, E-selectin, P-selectin, CD40 ligand, fibrinogen, von Willebrand factor, and D-dimer)...
  3. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..ClotFoam employs a new technology that bypasses the traditional mixture in situ of thrombin and fibrinogen, which translates in greater clotting efficacy and safety...
  4. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
    ..Aim 2 will determine the role of thrombin and the downstream effectors fibrinogen and PAR-1 in AAA...
  5. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..The thrombus probe is based on a peptide that binds to and has specificity for fibrin over circulating fibrinogen or other plasma proteins...
  6. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..3) Impaired FMD of the brachial artery and elevated PAI-1 and fibrinogen predict accelerated decline in lung function, increased emphysema and decreased LV end-diastolic volume over 6-..
  7. PLASMINOGEN AND PLASMIN: STRUCTURE AND FUNCTION
    Francis J Castellino; Fiscal Year: 2013
    ..part through their ability to bind to host human plasminogen (hPg) directly (PAM), or, indirectly (M1), via fibrinogen (Fg)/fibrin (Fn)...
  8. Fibronectin-binding Protein of Treponema Denticola in Periodontal Disease
    Xiaoping Xu; Fiscal Year: 2012
    ..denticola is very limited. The genome project of T. denticola has identified a new putative fibronectin/fibrinogen-binding protein gene, fbp (Gene ID: 2739776), which is homologous to an N-terminal segment of the prokaryotic FN-..
  9. Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis
    Steven M Kawut; Fiscal Year: 2010
    ..plasma measures, such as von Willebrand factor, soluble thrombomodulin, C-reactive protein, interleukin-6, and fibrinogen, are associated with RV mass and RV ejection fraction, and 3) to determine whether plasma measures of ..
  10. HTS platform for identification of regulators of cell adhesion molecule signaling
    Darren G Woodside; Fiscal Year: 2013
    ..Integrins bind a variety of extracellular ligands such as serum fibrinogen, extracellular matrix (ECM) components, and cell-surface counter receptors...
  11. Role of influenza-induced prothrombosis in Streptococcus pyogenes superinfections
    Michael S Chaussee; Fiscal Year: 2012
    ..pyogenes superinfections. Influenza infection induces thrombosis, which results in fibrinogen/fibrin (Fb) and fibronectin (Fn) deposition in the respiratory tract. These ae well-known ligands involved in S...
  12. Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study
    Gailen D Marshall; Fiscal Year: 2013
    ..outcomes will be changes in participants'systolic and diastolic blood pressure and their levels of CRP, fibrinogen, homocysteine, and interleukin-6...
  13. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013
    ..More recently fibrinogen and fibrin have been implicated in multiple sclerosis...
  14. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012
    ..for these activities was purified and identified unequivocally as pH-regulated Antigen 1 (Pra1p), also known as Fibrinogen Binding Protein 1, Fbp1, by mass spectrometry and amino acid sequence...
  15. A Novel Electrospun Vascular Graft
    David J Vachon; Fiscal Year: 2010
    ..These materials are prone to rapid protein (e.g. fibrinogen, fibrin) deposition, denaturation and subsequent adhesion and activation of blood platelets potentially leading ..
  16. Thrombosis Genetics, MI and Stroke in Older Adults
    Alexander P Reiner; Fiscal Year: 2012
    ..traditional risk factors, subclinical disease, and several important inflammation/thrombosis biomarkers (fibrinogen, C-reactive protein, factor VII, and others) are also available...
  17. Mechanism of Staphylocoagulase-activated Blood Clotting
    Paul E Bock; Fiscal Year: 2013
    ..Active SC/vWbp.ProT* complexes cleave fibrinogen (Fbg) to fibrin (Fbn), aiding growth of platelet-Fbn-bacteria vegetations. S...
  18. Treatment and Risk Factor Determinants of Cardiovascular Outcomes in BARI 2D
    Maria Mori Brooks; Fiscal Year: 2013
    ..During the five- year follow-up, plasminogen activator inhibitor-1 (PAI-1), C-reactive protein (CRP), fibrinogen, and D-dimer were lower in the insulin sensitization group compared with the insulin provision group, indicating ..
  19. Pathogen specific imaging of endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2013
    ..and D2-domains bind to thrombin (or the ProT imaging platform), while the COOH-terminal repeats region binds to fibrinogen at the same time. Therefore, staphylocoagulase firmly anchors the imaging probe in endocarditic vegetations...
  20. CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPE
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..b>Fibrinogen activates signaling via [unreadable]2 integrins and immune complexes ligate Fc receptors...
  21. Therapeutic-Expression of a Platelet-Specific Integrin
    DAVID ALLEN WILCOX; Fiscal Year: 2010
    ..abnormalities in the sequences encoding either the allb or beta3 subunit prevent GT platelets from binding fibrinogen and forming platelet aggregates...
  22. Mechanisms of the M protein in group A Streptococcus virulence
    Victor Nizet; Fiscal Year: 2013
    ..phagocytic clearance of GAS by recruiting specific host factors to the GAS surface, the most common being fibrinogen (Fg) and C4b-binding protein (C4BP), that interfere with the deposition of opsonic antibodies and the activation ..
  23. Bacterial Infection in COPD
    Sanjay Sethi; Fiscal Year: 2013
    ..A comprehensive assessment of airway inflammation in sputum will also be made. Serum c-reactive protein and fibrinogen will be used to measure systemic inflammation...
  24. Impaired integrin-dependent function of WASP-deficient platelets
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..mice are impaired (relative to respective control platelets) in adhesion and spreading on immobilized fibrinogen, a classic integrin outside-in dependent function, by the use of fluorescence microscopy and a photometric plate ..
  25. Analysis and Characterization of Trauma-Induced Coagulopathy
    Stephen R Wisniewski; Fiscal Year: 2013
    ..the cofactor factor Va and implicated systemic fibrinolytic activity in which unregulated proteolysis destroys fibrinogen and parts of the plasma coagulation system...
  26. Fibrinogen as a molecular mediator of cognitive dysfunction
    Frances Alexandra Loucks; Fiscal Year: 2010
    ..b>Fibrinogen, a critical component of blood coagulation, extravasates into the brain after vascular damage or BBB disruption...
  27. Community Assessment of Freeway Pollution and Health
    Doug Brugge; Fiscal Year: 2012
    ..pulmonary function tests from children and analyze multiple blood samples per person from adults for CRP and fibrinogen. Our study will be (1) the first to test associations between highway pollution gradients and biological markers ..
  28. Model of Platelet Adhesion and Thrombus Formation
    Michael R King; Fiscal Year: 2013
    ..A third platelet receptor, 1IIb23, binds to plasma fibrinogen and is critical for mediating platelet: platelet interactions that contribute to thrombus growth and stability...
  29. Mechanisms linking the hemostatic protease thrombin to arthritic disease
    Matthew J Flick; Fiscal Year: 2013
    ..Importantly, fibrinogen appears to be just one of many downstream effectors by which thrombin regulates events central to arthritis ..
  30. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
    ..Specifically, our previous studies show that Akt2 plays a role in promoting fibrinogen binding and dense granule secretion and that Akt2 knockout mice are resistant to arterial thrombosis...
  31. Role of the Plasminogen Activator Protease during Pneumonic Plague
    Wyndham W Lathem; Fiscal Year: 2013
    ..We propose to determine the extent of pulmonary thrombosis induced by Y. pestis, the roles that plasminogen and fibrinogen play in the control of pneumonic plague, the effects that Pla has on coagulation and fibrinolysis, and the ..
  32. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2013
    ..on the market to address this need, the body's own coagulation system based on the polymerization of fibrinogen, still represents the best approach...
  33. Assay for Monitoring Glycemic Control in Diabetics
    Ralph Ballerstadt; Fiscal Year: 2010
    ..g. hemoglobin HbA1c, IgM, IgG, serum albumin, and fibrinogen), followed by fluorescence detection using a microplate reader...
  34. Alternative Approaches for E. faecalis Infections
    Barbara E Murray; Fiscal Year: 2013
    ..We also identified a family of fibrinogen (FG)-binding MSCRAMMs that require the presence of Ebp pili to confer FG adherence to Efs cells and, recently, ..
  35. Fatty acids-mediated inflammation and ethnic disparity in pregnancy outcome
    Xinhua Chen; Fiscal Year: 2013
    ..Markers of inflammation will include TNF-[unreadable], IL-1, IL-6, IL-8, C-reactive protein, fibrinogen, soluble TNF- receptors 1 and 2 and adiponectin...
  36. Occult Small Vessel Cerebrovascular Disease in High Risk Families
    PAUL ALAN NYQUIST; Fiscal Year: 2013
    ..IL-6, TNF-[unreadable], hs- CRP, sVCAM-1, sICAM1, and MCP-1) and prothrombotic factors (PAI-1, Lp(a) and fibrinogen), endothelium dependent vascular reactivity (flow mediated dilatation [FMD] of the brachial artery, and ..
  37. FIBRINOGEN SIGNALING IN KIDNEY TISSUE REPAIR
    Vishal S Vaidya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fibrinogen (Fg) is a soluble, dimeric glycoprotein with a hexameric structure composed of three distinct pairs of disulfide-linked polypeptide chains (Fg1, Fg2 and Fg3)...
  38. Pathobiology of Staphyloccocus areus Endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2010
    ..expresses a unique non-proteolytic prothrombin (ProT) activator, staphylocoagulase that mediates recognition of fibrinogen by the active staphylocoagulase-ProT complex resulting in conversion of fibrinogen to fibrin...
  39. Functional G Protein pathways in platelet activation
    Satya P Kunapuli; Fiscal Year: 2010
    Platelet activation plays a major role in hemostasis and thrombosis. Platelet agonists cause shape change, fibrinogen receptor activation, dense granule release, and thromboxane A2 (TXA2) generation, leading to the activation of other ..
  40. Serine/Threonine Phosphatases and Platelet Physiology
    K Vinod Vijayan; Fiscal Year: 2013
    ..on the agonist-induced inside-out signaling to integrin [unreadable]IIb[unreadable]3 that regulates soluble fibrinogen binding, and outside-in signaling through aIIbb3 that controls the platelet cytoskeletal rearrangement...
  41. Deep Vein Thrombosis and Chronic Thrombotic Venous Disease
    Timothy A Morris; Fiscal Year: 2012
    ..Our previous studies disclosed that fibrinogen purified from CTEPH patients is somewhat resistant to lysis by exogenous plasmin...
  42. Predisposing Factors for the Development of Atrial Fibrillation Among Women
    Christine M Albert; Fiscal Year: 2010
    ..Biomarkers to be examined include hsCRP, Fibrinogen, ICAM-1, Lp (a), HgbA1C, and lipid levels...
  43. Mechanisms of normal and abnormal platelet homeostasis
    Joel S Bennett; Fiscal Year: 2010
    ..continues to study the conformational changes that regulate integrin activation states, focusing on the platelet fibrinogen receptor allb-beta-3...
  44. Citrullinated Antigens Bridge Innate and Adaptive Immunity in RA
    Jeremy Sokolove; Fiscal Year: 2013
    ..A recently identified target of the anti-citrullinated protein antibody (ACPA) response in RA is citrullinated fibrinogen (cFb)...
  45. Pathobiology of Staphyloccocus areus Endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2013
    ..expresses a unique non-proteolytic prothrombin (ProT) activator, staphylocoagulase that mediates recognition of fibrinogen by the active staphylocoagulase-ProT complex resulting in conversion of fibrinogen to fibrin...
  46. Integrin alphaIIbbeta3 Structure, Activation, and Ligand Binding
    Barry Coller; Fiscal Year: 2013
    ..as inputs to state-of-the art computational methods to identify interactions between the fibrinogen ?-module and [unreadable]IIb[unreadable]3 in addition to those made by the fibrinogen ?- chain C-terminal ..
  47. Transglutaminase-Based Imaging of Wound Healing
    Gregory W Faris; Fiscal Year: 2013
    ..is produced in part through the action of transglutaminase (TG) enzymes cross-linking plasma proteins such as fibrinogen and vitronectin...
  48. EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISM
    Aaron R Folsom; Fiscal Year: 2013
    ..Especially intriguing GWAS findings relate to the factor XI (F11) and fibrinogen gamma (FGG) regions...
  49. Hemostatic factors and sickle cell disease
    Punam Malik; Fiscal Year: 2013
    ..g., protease-activated receptors, fibrinogen, factor XI, and factor XIII], as well as negatively controls further thrombin generation through the activation ..
  50. Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque Formation
    Suresh C Tyagi; Fiscal Year: 2013
    ..Although a strong association between Ab, fibrinogen (Fg), and elevated level of homocysteine (Hcy), i.e...
  51. MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES
    Timothy A Springer; Fiscal Year: 2013
    ..and mechanism of activation of aIphalB3, its complexes with small molecules and macromolecules including fibrinogen and Del-1, and the structural basis for immune thrombocytopenic purpura...
  52. University Health Network's Application to Join the A2ALL Consortium
    David R Grant; Fiscal Year: 2013
    ..if plasma and liver tisssue expression of the novel CD4(+)CD25(+) regulatory T cell effector molecule - fibrinogen-like protein 2 (FGL2) - can be used as a biomarker for i) the rapidity and severity of hepatitis C recurrence ..
  53. Preconditioning Improves Coronary Patency
    Karin Przyklenk; Fiscal Year: 2012
    ..by novel evidence of a significant, PC-induced down-regulation of platelet P-selectin expression, platelet-fibrinogen binding, and formation of neutrophil-platelet aggregates (NPAs)...
  54. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    JAMES MORLEY ANDERSON; Fiscal Year: 2010
    ..epidermidis biofilm formed on cardiovascular biomaterials, 4) develop a treatment for infection by using the fibrinogen-Fbe binding mechanism by which Staphylococcus epidermidis specifically adheres to thrombus formations on ..
  55. Mechanism of Staphylocoagulase-activated Blood Clotting
    Paul E Bock; Fiscal Year: 2012
    ..which SC activates prothrombin (ProT) non-proteolytically and forms an SOProT complex that specifically converts fibrinogen (Fbg) into fibrin...
  56. Viper Resource Center (VRC) at Texas A&M University-Kingsville
    JOHN CARLOS PEREZ; Fiscal Year: 2013
    ..A good example of these molecules is the disintegrins, which are competitive inhibitors of fibrinogen and interfere with platelet function...
  57. ANALYSIS OF STAPHYLOCOCCUS AUREUS HOST INTERACTIONS
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..We propose to continue our very productive studies on Staphylococcal MSCRAMMs and their interactions with Fibrinogen (Fib) through further studies of the following three groups of MSCRAMMs...
  58. Functional PKC isoforms in platelets
    Satya P Kunapuli; Fiscal Year: 2012
    ..Work from this and other laboratories established that protein kinase C (PKC)-pathways modulate agonist-induced fibrinogen receptor activation and secretion in platelets...
  59. Role of Fibrinogen in Alzheimer's Disease
    Sidney Strickland; Fiscal Year: 2013
    ..We have also found that A binds to fibrinogen and has a dramatic effect on fibrin clot formation...
  60. Structure Function Analysis of Staphylococcal Complement Inhibitors
    BRIAN GEISBRECHT; Fiscal Year: 2012
    ..Together with a newly identified homolog denoted Ehp, the Extracellular Fibrinogen-binding Protein (Efb) defines a novel family of complement inhibitory proteins that disrupt downstream functions ..
  61. FIBRIN(OGEN) STRUCTURE AND INTERACTIONS
    LEONID V MEDVED; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fibrinogen is a multifunctional plasma protein that after conversion into fibrin contributes to hemostasis and other physiological and pathological processes through its interaction with different ..
  62. Novel Device for Sensitive, Small Sample Volume Assessment of Clot Elasticity
    Amy L Oldenburg; Fiscal Year: 2012
    ..To investigate the capabilities of RASOV, additional fibrinogen or antibodies will be added to blood to simulate hyperfibrinogenemia and hemophilia, respectively, which we ..
  63. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2004
    ..The role of fibrinogen and its macrophage-binding region will also be explored...
  64. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ..One is the mechanism causing exposure of the binding sites (receptors) for fibrinogen and fibrin monomer on the luminal membrane of the endothelial cells, initiating clinically silent or apparent ..
  65. PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    SANFORD SHATTIL; Fiscal Year: 1993
    ..First, the intracellular processes that regulate binding of fibrinogen to GP IIb-IIIa will be examined...
  66. HEMOSTATIC EFFECTS OF FIBRINOLYTIC THERAPY
    BARBARA ALEVRIADOU; Fiscal Year: 2000
    ..b>fibrinogen, von Willebrand factor (vWF)...
  67. PLATELETS, PLATELET AGGREGATES & PLASMINOGEN ACTIVATION
    Joseph Loscalzo; Fiscal Year: 1991
    ..platelet aggregate by tissue plasminogen activator (but not by streptokinase) initiates selective proteolysis of fibrinogen bound to the platelet surface and, in so doing, facilitates disaggregation...
  68. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2004
    ..a molecular level, platelet aggregation depends upon the binding of adhesive ligands, such as the plasma protein fibrinogen, to the major membrane protein on the platelet surface, integrin alphalibBeta3 (GPllb-llla)...
  69. BIOSYNTHESIS NAD STRUCTURE OF THE FIBRINOGEN RECEPTOR
    Paul Bray; Fiscal Year: 1990
    The goal of this project is to characterize the synthesis and structure of the fibrinogen receptor on the plasma membrane of platelets...
  70. Enhanced Cryoprecipiate in Wound Healing
    Edward Shanbrom; Fiscal Year: 2007
    ..More crude fibrinogen preparations, such as cryoprecipitate made from patient's own blood on location, appear to have better ..
  71. MOLECULAR MARKER FOR INVASIVE CANDIDA ALBICANS
    MARGARET HOSTETTER; Fiscal Year: 2001
    ..facilitation of epithelial and endothelial adhesion by recognition of RGD sequences in proteins such as iC3b and fibrinogen that serve as substrates for adhesion...
  72. CELLULAR CONSEQUENCES OF DEFECTIVE IIB AND IIIA GENES
    Paul Bray; Fiscal Year: 1993
    ..Platelets from patients with this disease do not bind fibrinogen and therefore, cannot participate in normal blood clotting...
  73. Physiological Role of Fibrin Anti-Thrombin I Activities
    MICHAEL MOSESSON; Fiscal Year: 2005
    Thrombin binding to fibrinogen at its substrate recognition sites in the central E domain leads to proteolytic conversion of fibrinogen to fibrin...
  74. FIBRINOGEN RECEPTORS IN HEREDITARY THROMBOPATHIA
    Thomas Bell; Fiscal Year: 1991
    ..In initial studies, glycoprotein IIb-IIIa content, 125-labeled fibrinogen binding, gold-labeled fibrinogen binding, electron micrographic morphology, platelet counts and clot retraction ..
  75. BIOSYNTHESIS AND GENETICS OF GLYCOPROTEINS IIB AND IIIA
    Marc Shuman; Fiscal Year: 1993
    ..The heterodimer is the primary receptor for fibrinogen, and is critical for normal blood clotting...
  76. FIBRINOGEN--ROLE OF THE GAMMA VARIANT
    David Farrell; Fiscal Year: 2001
    The broad, long-term objectives of the applicant are to define the roles of fibrinogen in hemostasis and thrombosis. This proposal addresses the issue of fibrin clot strength, a critical factor in the outcome of fibrinolytic therapy...
  77. BASIC AND CLINICAL STUDIES OF COAGULATION PROTEINS
    Charles Francis; Fiscal Year: 2003
    ..established investigators to study basic and clinical aspects of hemostasis and vascular biology with a focus on fibrinogen, fibrin and the vessel wall...