calcium

Summary

Summary: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

Top Publications

  1. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  2. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
  3. pmc Crystal structure of the calcium release-activated calcium channel Orai
    Xiaowei Hou
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Science 338:1308-13. 2012
  4. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
  5. pmc Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurosci 30:6838-51. 2010
  6. pmc The crystal structure of a voltage-gated sodium channel
    Jian Payandeh
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    Nature 475:353-8. 2011
  7. ncbi A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    Stefan Feske
    The CBR Institute for Biomedical Research, and the Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 441:179-85. 2006
  8. pmc An expanded palette of genetically encoded Ca²⁺ indicators
    Yongxin Zhao
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Science 333:1888-91. 2011
  9. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
  10. pmc Glutamate-dependent neuroglial calcium signaling differs between young and adult brain
    Wei Sun
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Science 339:197-200. 2013

Detail Information

Publications450 found, 100 shown here

  1. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  2. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
    Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus (type 2 DM)...
  3. pmc Crystal structure of the calcium release-activated calcium channel Orai
    Xiaowei Hou
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Science 338:1308-13. 2012
    The plasma membrane protein Orai forms the pore of the calcium release-activated calcium (CRAC) channel and generates sustained cytosolic calcium signals when triggered by depletion of calcium from the endoplasmic reticulum...
  4. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
    ..Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx...
  5. pmc Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    Evangelia Emmanouilidou
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurosci 30:6838-51. 2010
    ..We have found that, in this model, alpha-synuclein is secreted by externalized vesicles in a calcium-dependent manner...
  6. pmc The crystal structure of a voltage-gated sodium channel
    Jian Payandeh
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    Nature 475:353-8. 2011
    ..This structure provides the template for understanding electrical signalling in excitable cells and the actions of drugs used for pain, epilepsy and cardiac arrhythmia at the atomic level...
  7. ncbi A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    Stefan Feske
    The CBR Institute for Biomedical Research, and the Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 441:179-85. 2006
    ..We propose that Orai1 is an essential component or regulator of the CRAC channel complex...
  8. pmc An expanded palette of genetically encoded Ca²⁺ indicators
    Yongxin Zhao
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Science 333:1888-91. 2011
    Engineered fluorescent protein (FP) chimeras that modulate their fluorescence in response to changes in calcium ion (Ca(2+)) concentration are powerful tools for visualizing intracellular signaling activity...
  9. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
    ..Finally, we summarize the recent literature on putative molecular players in synaptic plasticity and the effects of genetic manipulations and other modulatory influences...
  10. pmc Glutamate-dependent neuroglial calcium signaling differs between young and adult brain
    Wei Sun
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Science 339:197-200. 2013
    ..shows that astrocytes exhibit metabotropic glutamate receptor 5 (mGluR5)-dependent increases in cytosolic calcium ions (Ca(2+)) in response to glutamatergic transmission and, in turn, modulate neuronal activity by their Ca(2+)-..
  11. ncbi Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    Nat Methods 1:31-7. 2004
    ..Furthermore, by combining this method with calcium indicator loading of cell populations, we demonstrated distinct calcium dynamics in astroglial and neuronal ..
  12. pmc STIM1, an essential and conserved component of store-operated Ca2+ channel function
    Jack Roos
    Torrey Pines Therapeutics, Inc, La Jolla, CA 92037, USA
    J Cell Biol 169:435-45. 2005
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels...
  13. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
    ..We therefore demonstrate that Ca(2+)-dependent release of D-serine from an astrocyte controls NMDAR-dependent plasticity in many thousands of excitatory synapses nearby...
  14. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993
    ....
  15. pmc Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins
    Takeharu Nagai
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 101:10554-9. 2004
    ..Our study provides an important guide for the development and improvement of indicators using GFP-based FRET...
  16. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
    ..patients, data on 40,538 hemodialysis patients with at least one determination of serum phosphorus and calcium during the last 3 mo of 1997 were analyzed...
  17. pmc A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
    Diego De Stefani
    Department of Biomedical Science, University of Padua, 35121 Padua, Italy
    Nature 476:336-40. 2011
    ..of aerobic metabolism and cell survival, but the molecular identity of the Ca(2+) channel, the mitochondrial calcium uniporter, is still unknown...
  18. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons...
  19. ncbi Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin
    A Miyawaki
    Department of Pharmacology, University of California, San Diego, La Jolla 92093 0647, USA
    Nature 388:882-7. 1997
    ..Thus FRET between GFP mutants can monitor localized Ca2+ signals and protein heterodimerization in individual live cells...
  20. pmc Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 473:528-31. 2011
    ..ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein response...
  21. pmc MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
    Fabiana Perocchi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 467:291-6. 2010
    Mitochondrial calcium uptake has a central role in cell physiology by stimulating ATP production, shaping cytosolic calcium transients and regulating cell death...
  22. doi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors...
  23. ncbi A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein
    J Nakai
    Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, 444 8585, Japan
    Nat Biotechnol 19:137-41. 2001
    ..G-CaMP will be a useful tool for visualizing intracellular Ca2+ in living cells. Mutational analysis, together with previous structural information, suggests the residues that may alter the fluorescence of GFP...
  24. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
  25. pmc Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
    Elizabeth Murphy
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Physiol Rev 88:581-609. 2008
    ..During ischemia, when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (Ca(2+)), which further accelerates ATP depletion...
  26. pmc Differential innate immune signalling via Ca(2+) sensor protein kinases
    Marie Boudsocq
    Department of Genetics, Harvard Medical School, Center for Computational and Integrative Biology, Massachusetts General Hospital, Massachusetts 02114, USA
    Nature 464:418-22. 2010
    ..Using a functional genomic screen and genome-wide gene expression profiling, here we show that four calcium-dependent protein kinases (CDPKs) are Ca(2+)-sensor protein kinases critical for transcriptional reprogramming in ..
  27. doi Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX
    Oliver Borst
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 302:C644-51. 2012
    ..The present observations demonstrate that eryptotic erythrocytes adhere to endothelial cells of the vascular wall in part by interaction of phosphatidylserine exposed at the erythrocyte surface with endothelial CXCL16...
  28. doi Deoxygenation-induced and Ca(2+) dependent phosphatidylserine externalisation in red blood cells from normal individuals and sickle cell patients
    Erwin Weiss
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cell Calcium 51:51-6. 2012
    ..The high affinity component accounted for PS scrambling in ≥2/3rd RBCs. It is likely to be most significant in vivo and may be involved in the pathophysiology of SCD or other conditions involving eryptosis...
  29. ncbi Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase
    Andrew P Somlyo
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, PO Box 800736, Charlottesville, VA 22908 0736
    Physiol Rev 83:1325-58. 2003
    ..It is a potentially important therapeutic target and a subject for translational research...
  30. ncbi Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    M Uehata
    Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
    Nature 389:990-4. 1997
    ..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
  31. ncbi Orai1 is an essential pore subunit of the CRAC channel
    Murali Prakriya
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 443:230-3. 2006
    ..These changes in ion selectivity provide strong evidence that Orai1 is a pore subunit of the CRAC channel...
  32. pmc Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
    Jaime N Guzman
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nature 468:696-700. 2010
    ..of green fluorescent protein targeted to the mitochondrial matrix, that the engagement of plasma membrane L-type calcium channels during normal autonomous pacemaking created an oxidant stress that was specific to vulnerable SNc ..
  33. pmc Coping with stresses: roles of calcium- and calcium/calmodulin-regulated gene expression
    Anireddy S N Reddy
    Department of Biology, Program in Molecular Plant Biology, Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    Plant Cell 23:2010-32. 2011
    ..We will discuss emerging paradigms in the field, highlight the areas that need further investigation, and present some promising novel high-throughput tools to address Ca(2+)-regulated transcriptional networks...
  34. doi Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway
    Shobana Ganesan
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, United States
    Toxicology 294:54-60. 2012
    ..alone or in presence of pooled human liver microsomes neither produced significant effect on intraerythrocytic calcium levels nor affected the phosphatidyl serine asymmetry of the normal and G6PD-deficient human erythrocytes as ..
  35. pmc Role of mitochondrial Ca2+ in the regulation of cellular energetics
    Brian Glancy
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20817, USA
    Biochemistry 51:2959-73. 2012
    b>Calcium is an important signaling molecule involved in the regulation of many cellular functions...
  36. doi The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
    Hawon Cho
    Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
    Nat Neurosci 15:1015-21. 2012
    ..These results indicate that ANO1 is a heat sensor that detects nociceptive thermal stimuli in sensory neurons and possibly mediates nociception...
  37. ncbi The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
    John T R Isaac
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 54:859-71. 2007
    ..Here, we bring together recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity...
  38. doi TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    Antonella Caputo
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova 16148, Italy
    Science 322:590-4. 2008
    b>Calcium-dependent chloride channels are required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability. The molecular identity of these membrane proteins is still unclear...
  39. ncbi CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
    M Vig
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 312:1220-3. 2006
    ..Although overexpression of CRACM1 did not affect CRAC currents, RNAi-mediated knockdown disrupted its activation. CRACM1 could be the CRAC channel itself, a subunit of it, or a component of the CRAC signaling machinery...
  40. pmc Nanodomain coupling between Ca²⁺ channels and sensors of exocytosis at fast mammalian synapses
    Emmanuel Eggermann
    IST Austria Institute of Science and Technology Austria, Am Campus 1, A 3400 Klosterneuburg, Austria
    Nat Rev Neurosci 13:7-21. 2012
    ..Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission...
  41. ncbi Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
    Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking.
  42. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
    Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important...
  43. ncbi Necrotic death as a cell fate
    Wei Xing Zong
    Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, New York 11794, USA
    Genes Dev 20:1-15. 2006
    ..By initiating these adaptive responses, programmed cell necrosis may serve to maintain tissue and organismal integrity...
  44. ncbi Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    David D McKemy
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 416:52-8. 2002
    ....
  45. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  46. pmc Circularly permuted green fluorescent proteins engineered to sense Ca2+
    T Nagai
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
    Proc Natl Acad Sci U S A 98:3197-202. 2001
    ..The Ca(2+)-dependent interaction between calmodulin and M13 in HeLa cells was monitored by the association of the two halves of GFP, neither of which was fluorescent by itself...
  47. ncbi Annexins: linking Ca2+ signalling to membrane dynamics
    Volker Gerke
    Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Munster, Germany
    Nat Rev Mol Cell Biol 6:449-61. 2005
    ..These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration...
  48. doi Skeletal muscle fatigue: cellular mechanisms
    D G Allen
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Physiol Rev 88:287-332. 2008
    ....
  49. doi GABAergic hub neurons orchestrate synchrony in developing hippocampal networks
    P Bonifazi
    Institut de Neurobiologie de la Méditerranée INSERM U901, Universitéde la Méditerranée, Parc Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 9, France
    Science 326:1419-24. 2009
    ..These findings establish a central role for GABAergic interneurons in shaping developing networks and help provide a conceptual framework for studying neuronal synchrony...
  50. doi Calcium-dependent phospholipid scrambling by TMEM16F
    Jun Suzuki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Nature 468:834-8. 2010
    ..A patient with Scott syndrome, which results from a defect in phospholipid scrambling activity, was found to carry a mutation at a splice-acceptor site of the gene encoding TMEM16F, causing the premature termination of the protein...
  51. doi Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Hei
    Kuanrong Li
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Heart 98:920-5. 2012
    It has been suggested that a higher calcium intake might favourably modify cardiovascular risk factors. However, findings of an ultimately decreased risk of cardiovascular disease (CVD) are limited...
  52. ncbi The mitochondrial calcium uniporter is a highly selective ion channel
    Yuriy Kirichok
    Howard Hughes Medical Institute, Department of Cardiovascular Research, Children s Hospital, andHarvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:360-4. 2004
    ..The channel is inwardly rectifying, making it especially effective for Ca2+ uptake into energized mitochondria. Thus, we conclude that the properties of the current mediated by this novel channel are those of the MCU...
  53. ncbi The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
    Rebecca L Hurley
    Departments of Medicine and Biochemistry, Dartmouth Medical School and the Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Biol Chem 280:29060-6. 2005
    ..These data indicate that the CaMKKs function in intact cells as AMPKKs, predicting wider roles for these kinases in regulating AMPK activity in vivo...
  54. pmc Inositol trisphosphate receptor Ca2+ release channels
    J Kevin Foskett
    Department of Physiology, University of Pennsylvania, Philadelphia 19104 6085, USA
    Physiol Rev 87:593-658. 2007
    ..The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular ..
  55. doi Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin
    Nazneen Shaik
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:678-86. 2012
    ..In conclusion, naringin blunts the increase of cytosolic Ca(2+) concentration, the shrinkage, the cell membrane scrambling and thus the suicidal death of erythrocytes following energy depletion or oxidative stress...
  56. doi Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis
    Andrea Rasola
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy
    Cell Calcium 50:222-33. 2011
    ....
  57. ncbi Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease
    A Levin
    Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
    Kidney Int 71:31-8. 2007
    ..Blood for parathyroid hormone (PTH), vitamin D metabolites, creatinine, calcium (Ca), and phosphorus (P) were drawn between June and October 2004...
  58. pmc RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
    Pascal S Kaeser
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5453, USA
    Cell 144:282-95. 2011
    ..We propose that RIMs tether N- and P/Q-type Ca(2+) channels to presynaptic active zones via a direct PDZ-domain-mediated interaction, thereby enabling fast, synchronous triggering of neurotransmitter release at a synapse...
  59. doi Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis
    Suetonia C Palmer
    Department of Medicine, University of Otago, Christchurch, New Zealand
    JAMA 305:1119-27. 2011
    Clinical practice guidelines on the management of mineral and bone disorders due to chronic kidney disease recommend specific treatment target levels for serum phosphorus, parathyroid hormone, and calcium.
  60. ncbi Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..Here we show that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca(2+)) within the barrel cortex of adult mice...
  61. ncbi Calcium, ATP, and ROS: a mitochondrial love-hate triangle
    Paul S Brookes
    University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 287:C817-33. 2004
    The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP generation. Calcium is a key regulator of mitochondrial function and acts at several levels within the organelle to stimulate ATP synthesis...
  62. doi TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
    b>Calcium (Ca(2+))-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and ..
  63. pmc Functional specificity of local synaptic connections in neocortical networks
    Ho Ko
    Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Nature 473:87-91. 2011
    ..Our results reveal the degree of functional specificity of local synaptic connections in the visual cortex, and point to the existence of fine-scale subnetworks dedicated to processing related sensory information...
  64. ncbi TRP channels as cellular sensors
    David E Clapham
    Howard Hughes Medical Institute, Pediatric Cardiology, Children s Hospital of Boston, Department of Neurobiology, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 426:517-24. 2003
    ..They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell...
  65. ncbi Coupling endoplasmic reticulum stress to the cell death program
    R V Rao
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Death Differ 11:372-80. 2004
    ..ER) regulates protein synthesis, protein folding and trafficking, cellular responses to stress and intracellular calcium (Ca(2+)) levels...
  66. ncbi Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
    Julia Foreman
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Nature 422:442-6. 2003
    ..This indicates that NADPH oxidases control development by making ROS that regulate plant cell expansion through the activation of Ca2+ channels...
  67. ncbi Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
    Maria Høyer-Hansen
    Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, 2100 Copenhagen, Denmark
    Mol Cell 25:193-205. 2007
    ..Here, we demonstrate that a rise in the free cytosolic calcium ([Ca(2+)](c)) is a potent inducer of macroautophagy...
  68. pmc Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    I Kehat
    Cardiovascular Research Laboratory, Department of Physiology and Biophysics, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
    J Clin Invest 108:407-14. 2001
    ..Establishment of this unique differentiation system may have significant impact on the study of early human cardiac differentiation, functional genomics, pharmacological testing, cell therapy, and tissue engineering...
  69. pmc Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
    Robert D Burgoyne
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, UK
    Nat Rev Neurosci 8:182-93. 2007
    In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function...
  70. pmc Pathways towards and away from Alzheimer's disease
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nature 430:631-9. 2004
    ..But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies...
  71. pmc Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    Anna C Schinzel
    Howard Hughes Medical Institute and Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12005-10. 2005
    Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix calcium and is characterized by the opening of the PT pore (PTP)...
  72. pmc NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
    Raz Palty
    Department of Physiology, and Zlotowski Center for Neuroscience, Ben Gurion University of Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 107:436-41. 2010
    ..Taken together, our results converge to the conclusion that NCLX is the long-sought mitochondrial Na(+)/Ca(2+) exchanger...
  73. ncbi Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 366:575-80. 1993
    ..and features a large extracellular domain, containing clusters of acidic amino-acid residues possibly involved in calcium binding, coupled to a seven-membrane-spanning domain like those in the G-protein-coupled receptor superfamily.
  74. ncbi Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity
    Felice Arcuri
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Prostate 60:130-40. 2004
    ..as a growth-related protein, knowledge of the biological actions of TCTP has been recently extended to include calcium binding, regulation of apoptosis, and microtubules stabilization...
  75. ncbi Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
    Angela Woods
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Cell Metab 2:21-33. 2005
    ..These results demonstrate that AMPK is regulated by at least two upstream kinases and suggest that AMPK may play a role in Ca(2+)-mediated signal transduction pathways...
  76. pmc Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels
    Qingtang Lin
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 12:748-54. 2010
    ..Moreover, the protective effect of astrocytes resulted from their sequestering calcium from the cytoplasm of tumor cells...
  77. pmc TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
    Eiji Shigetomi
    Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Neurosci 15:70-80. 2011
    ..Here, using a membrane-tethered, genetically encoded calcium indicator (Lck-GCaMP3), we report the serendipitous discovery of a new type of Ca(2+) signal in rat hippocampal ..
  78. ncbi Defective membrane repair in dysferlin-deficient muscular dystrophy
    Dimple Bansal
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nature 423:168-72. 2003
    ..Our findings show that disruption of the muscle membrane repair machinery is responsible for dysferlin-deficient muscle degeneration, and highlight the importance of this basic cellular mechanism of membrane resealing in human disease...
  79. ncbi Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 282:11590-601. 2007
    ..Memantine and the anti-NR1 antibody also attenuated a rapid ADDL-induced increase in intraneuronal calcium, which was essential for stimulated ROS formation...
  80. doi Glutamate receptors, neurotoxicity and neurodegeneration
    Anthony Lau
    Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Pflugers Arch 460:525-42. 2010
    ....
  81. ncbi Mitochondrial transport of cations: channels, exchangers, and permeability transition
    P Bernardi
    Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche Center for the Study of Biomembranes, Padova, Italy
    Physiol Rev 79:1127-55. 1999
    ....
  82. ncbi BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
    Luca Scorrano
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Department of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Science 300:135-9. 2003
    ..embryonic fibroblasts deficient for BAX and BAK (DKO cells) were found to have a reduced resting concentration of calcium in the ER ([Ca2+]er) that results in decreased uptake of Ca2+ by mitochondria after Ca2+ release from the ER...
  83. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
    ..Therefore, because astrocytes discriminate and integrate synaptic information, we propose that they can be considered as cellular elements involved in the information processing by the nervous system...
  84. ncbi Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
    A Deniaud
    Universite de Versailles SQY, CNRS UMR 8159, 45, Versailles, France
    Oncogene 27:285-99. 2008
    ....
  85. pmc Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
    P Pinton
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Oncogene 27:6407-18. 2008
    ..Among the latter, a clear role is played by calcium (Ca(2+)), the ubiquitous second messenger involved in the control of a broad variety of physiological events...
  86. doi What is the mitochondrial permeability transition pore?
    Andrew P Halestrap
    Department of Biochemistry and Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol, UK
    J Mol Cell Cardiol 46:821-31. 2009
    Under conditions of mitochondrial calcium overload, especially when accompanied by oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a non-specific pore, the mitochondrial permeability transition pore (..
  87. pmc NAADP mobilizes calcium from acidic organelles through two-pore channels
    Peter J Calcraft
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
    Nature 459:596-600. 2009
    ..TPCs therefore provide new insights into the regulation and organization of Ca(2+) signals in animal cells, and will advance our understanding of the physiological role of NAADP...
  88. pmc Calcium channels and pumps in cancer: changes and consequences
    Gregory R Monteith
    School of Pharmacy, The University of Queensland, Brisbane 4075, Australia
    J Biol Chem 287:31666-73. 2012
    ..In some cases, these Ca(2+) channels or pumps are potential therapeutic targets for specific cancer subtypes or correlate with prognosis...
  89. doi Mitochondria as sensors and regulators of calcium signalling
    Rosario Rizzuto
    Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Via G Colombo 3, 35131 Padua, Italy
    Nat Rev Mol Cell Biol 13:566-78. 2012
    During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance...
  90. doi Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames
    Emile G Magny
    School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QG, UK
    Science 341:1116-20. 2013
    ..Here, we describe two peptides of less than 30 amino acids regulating calcium transport, and hence influencing regular muscle contraction, in the Drosophila heart...
  91. ncbi A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 311:1012-7. 2006
    ..Activity-dependent calcium signaling induced a calcineurin-mediated dephosphorylation of MEF2A at serine-408 and, thereby, promoted a switch ..
  92. doi Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    The intracellular calcium concentration ([Ca(2+)]) has important roles in the triggering of neurotransmitter release and the regulation of short-term plasticity (STP)...
  93. ncbi Sphingosine-1-phosphate: an enigmatic signalling lipid
    Sarah Spiegel
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    Nat Rev Mol Cell Biol 4:397-407. 2003
    ..These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement...
  94. pmc Glucose sensing in L cells: a primary cell study
    Frank Reimann
    Cambridge Institute for Medical Research, Department of Clinical Biochemistry, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Cell Metab 8:532-9. 2008
    ..of a fluorescent protein, we studied the characteristics of primary L cells by electrophysiology, fluorescence calcium imaging, and expression analysis and show that single L cells are electrically excitable and glucose responsive...
  95. pmc PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
    Sonia Gandhi
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK
    Mol Cell 33:627-38. 2009
    ..PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function in PINK1-deficient mammalian neurons...
  96. ncbi Regulation of contraction in striated muscle
    A M Gordon
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 7290, USA
    Physiol Rev 80:853-924. 2000
    ..9) Different Tn subunit isoforms can modulate the cross-bridge detachment rate as shown by studies with mutant regulatory proteins in myotubes and in in vitro motility assays. (ABSTRACT TRUNCATED)..
  97. pmc NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis
    June M Kwak
    Cell and Developmental Biology Section, Division of Biological Sciences and Center for Molecular Genetics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0116, USA
    EMBO J 22:2623-33. 2003
    ..These data provide direct molecular genetic and cell biological evidence that ROS are rate-limiting second messengers in ABA signaling, and that the AtrbohD and AtrbohF NADPH oxidases function in guard cell ABA signal transduction...
  98. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003
    ..Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription...
  99. ncbi Transcriptional regulation by calcium, calcineurin, and NFAT
    Patrick G Hogan
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:2205-32. 2003
  100. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  101. doi A genetically encoded calcium indicator for chronic in vivo two-photon imaging
    Marco Mank
    Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nat Methods 5:805-11. 2008
    ..We increased the signal strength of troponin C-based calcium biosensors in the low-calcium regime by mutagenesis and domain rearrangement within the troponin C calcium ..

Research Grants81

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..5-1 micron corrals, smaller cortical cytoskeletal subdomains and protein islands. Assays for calcium flux, secretory response and cytokine production will correlate functional responses with receptor immobilization,..
  3. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..investigate the effect of chitosan administered in dosed feed on bone osteopenia and osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other ..
  4. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..investigate the effect of chitosan administered in dosed feed on bone osteopenia and osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other ..
  5. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..uncoupling protein 2 (UCP2), which also regulates production of reactive oxygen species (ROS) and cytosolic calcium, and mast cell activation. There are no effective therapies for CFS...
  6. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..We focus on ocular motility abnormalities in mice carrying mutations of the CACNA1A gene of the P/Q (CaV2.1) calcium channel, but the results should be applicable to other causes and manifestations of cerebellar dysfunction...
  7. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..LPA and S1P regulate chemotaxis, stress responses, cytoskeletal organization, calcium signaling, cell survival, apoptosis, autophagy, and gene transcription...
  8. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..Other investigators have proposed that calpain may be regulated by the non-voltage gated calcium channel TRPM7, by direct phosphorylation by the extracellular response kinase ERK, or by phosphorylation of ..
  9. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..of the a3 pump modulates excitability of central nervous system neurons, as well as the levels of cytoplasmic calcium and other second messengers implicated in regulating synaptic function, growth and maturation...
  10. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..and the rational design of therapeutic corrections will be addressed better as we understand what controls stored calcium, and what the stored calcium controls...
  11. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Multiple mechanisms such as lipotoxicity, glucotoxicity, oxidative stress, impaired myocardial calcium homeostasis and impaired insulin signaling have been implicated...
  12. Paul E Micevych; Fiscal Year: 2016
    ..The resulting rise in free cytoplasmic calcium is sufficient to stimulate neuroP synthesis...
  13. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..Aim 2 will probe the role of 1,25(OH)2D3-VDR to stimulate calcium and phosphate translocation in small intestine and kidney through the enhanced expression of epithelial calcium ..
  14. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..In this program we focus on a group of interlocking themes, including the biology of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and the function of its ligands and toll like receptor ligands ..
  15. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..Now recent evidence has emerged demonstrating that the Na/Ca exchanger plays a role in nuclear calcium homeostasis in some cells which immediately suggests that there must be a sodium concentration gradient across ..
  16. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..To accomplish this goal, I have focused calcium signaling in heart function and development since undergraduate studies...
  17. Masayuki Yazawa; Fiscal Year: 2015
    ..To accomplish this goal, I have focused calcium signaling in heart function and development since undergraduate studies...
  18. MATTHEW PETER COGGINS; Fiscal Year: 2014
    ..IKKB deletion produces moderate contractile dysfunction in young mice associated with altered cardiomyocyte (CM) calcium handling...
  19. Petr Tvrdik; Fiscal Year: 2014
    ..Intracellular calcium transients represent such convenient, measurable signals that strongly correlate with cellular activity...
  20. Sharon M Moe; Fiscal Year: 2014
    ..by treating CKD animals with high turnover bone disease, or low turnover bone disease induced by increased calcium intake, with an anti-VEGF antibody (bevacizumab) or zoledronic acid in a 2 x 2 design, and biochemical, skeletal, ..
  21. Thomas L Clemens; Fiscal Year: 2016
    ..function Preliminary studies suggest that OC increases pancreatic insulin secretion by increasing intracellular calcium ([Ca2+]i ), which we postulate occurs secondarily to interaction with a G-protein receptor on the b-cell...
  22. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..of elevated parathyroid hormone (PTH), typically a consequence of depressed vitamin D levels and/or low calcium intake, is also high in African Americans...
  23. James B Martins; Fiscal Year: 2014
    ..Tissue excised from the endocardial focus is studied in vitro with pacing protocols generating cellular calcium based oscillations termed delayed afterdepolarization (DADs) giving rise to an arrhythmia called triggered ..
  24. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..endoplasmic reticulum (ER or sarcoplasmic reticulum in cardiac myocytes) is a principal site for protein folding, calcium storage and calcium signaling...
  25. Mary K Sheats; Fiscal Year: 2016
    ..are known cell membrane and actin binding proteins regulated by protein kinase C (PKC) phosphorylation and calcium/calmodulin binding...
  26. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Over the last ten years, we have undertaken a program of targeting important calcium cycling proteins which has led to the first in man clinical trial of gene therapy for heart failure using adeno-..
  27. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..Mitochondria then take up this iron via the electrogenic calcium uniporter to promote intramitochondrial OH7 formation, the mitochondrial permeability transition (MPT) and ..
  28. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..To this end, mitochondrial function (oxygen uptake, ROS production, mitochondrial coupling, and calcium transport) will be evaluated in mitochondria isolated from several tissues (liver, skeletal muscle, heart, and ..
  29. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..NO release, measure reactive oxygen species, determine the redox status of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), and assess intracellular Ca2+...
  30. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..is based on the fact that we just don't know how much is enough (we do know from our previous studies on calcium metabolism that these levels are not toxic). 3...
  31. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
    ..and their metabolites in trafficking of Rhodopsin 1 and Transient Receptor Potential (TRP) and in maintenance of calcium homeostasis mediated by TRP family of proteins...
  32. MARK REID PHILIPS; Fiscal Year: 2015
    ..and that phospho-K-Ras forms a trimolecular complex with Bcl-XL and the IP3 receptor (IP3R) and regulates the calcium channel activity...
  33. David E Clapham; Fiscal Year: 2014
    ..and control information flow from one synapse to another, and in particular, to initiate changes in intracellular calcium that control neurotransmitter release...
  34. LIVER PRESERVATION FOR TRANSPLANTATION
    John J Lemasters; Fiscal Year: 2012
    ..leads to necrosis and apoptosis;how enhanced ROS formation contributes to MPT onset;and if mitochondrial calcium dysregulation contributes to MPT onset...
  35. ANNE LOUISE SCHAFER; Fiscal Year: 2015
    ..Other factors are likely involved as well, such as non-vitamin D-mediated calcium malabsorption, signals related to decreased skeletal loading, and changes in fat-secreted hormones or estrogen (..
  36. Tsung Ung W Woo; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Neural circuits of inhibitory neurons that contain the calcium-binding protein parvalbumin (PV) are functionally altered in schizophrenia (SZ)...
  37. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
  38. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial obstruction, and ..
  39. Jingsong Zhou; Fiscal Year: 2014
    ..We ask if muscle is also involved in the disease onset and progression. Muscle cells use Calcium (Ca) as a messenger to control their contraction activity, while excessive elevation of Ca inside the cell will ..
  40. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..cardiomyocytes from cell death by rapid activation of PI3K, eNOS and protein kinase G and increased diastolic calcium levels (Brero et al. 2010)...
  41. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..other degenerative changes in dendrites such as dilation of the smooth endoplasmic reticulum (SER), the major calcium storage component of PN dendrites...
  42. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..to identify how EGFR regulates excessive PTHrP production in lung cancer and causes life-threatening elevated calcium levels...
  43. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..a novel feed-forward regulation of NOX5 by hydrogen peroxide (H2O2) acting through a signaling pathway involving calcium and the non-receptor tyrosine kinase c-Abl...
  44. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..the hypercalcemic toxicity. Consequently, current on-market VDRMs require frequent dose titration and serum calcium monitoring, which causes considerable challenges in clinical management...
  45. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..We will use state of the art techniques such as calcium imaging and calcium uncaging to test the hypothesis: Calcium ion transients play a critical role in determining ..
  46. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..This hormone is involved in the complex regulation of blood calcium level by inhibiting bone resorption...
  47. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..and n6 fatty acids bind to receptors on resident macrophages resulting in a sustained increase in cytoplasmic calcium, activation of the cPLA2/5-lipoxygenase pathway and fatty acid binding protein-dependent leukotriene synthesis...
  48. Leonard H Augenlicht; Fiscal Year: 2015
    ..western countries: 1) the NWD is formulated on the basis of nutrient density to reflect the higher fat and lower calcium and vitamin D3 levels consumed by large segments of the population;2) tumors develop in control C57Bl/6 mice fed ..
  49. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..Hypercalcemic toxicity that interferes with calcium homeostasis and detriments body functions is the limiting factor to expanded use of on-market VDRMs...
  50. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..and HB-EGF on Ang II and ET-1-stimulated transactivation of the EGFR;2) whether Ac-SDKP inhibits the effects of calcium ionophores or EGF on p42/44 MAPK and collagen synthesis;3) whether PLC, EGFR, cSrc, calmodulin kinase or IP3 ..
  51. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..Hypercalcemic toxicity that interferes with calcium homeostasis and detriments body functions is the limiting factor to expanded use of on-market VDRMs...
  52. Regulation of IFN-beta induction by P2X7 purinergic receptor signaling
    JUDITH ANNE SMITH; Fiscal Year: 2011
    ..P2X7 ligation is known to initiate multiple signal transduction pathways: the contribution of calcium and MAP-kinase signaling pathways to the effect of BzATP on IFN- [unreadable] induction will be analyzed...
  53. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Calcium-sensing receptors are molecules on the membranes of cells that sense the level of calcium in the environment and ..
  54. Hamid I Akbarali; Fiscal Year: 2014
    ..produced during colonic inflammation cause nitration of the tyrosine residues within the c-terminus of the calcium channel and result in down-regulation of channel function...
  55. Raghu R Krishnamoorthy; Fiscal Year: 2014
    ..of G-protein coupled receptors, namely, the ETA and ETB receptors, which are B predominantly linked to the calcium and nitric oxide signaling pathways respectively...
  56. E Sherwood Brown; Fiscal Year: 2014
    ..antiseizure and bipolar disorder medication that decreases glutamate release through interactions with sodium and calcium channels...
  57. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ..Molecular interactions of hair cell voltage-gated calcium channels (VGCC) with synaptic proteins and with scaffolding proteins will be investigated...
  58. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..Filipinos) who had electron beam computed tomography (EBCT) scans of the chest and abdomen for coronary artery calcium (CAC) and visceral fat (VF), respectively...
  59. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial obstruction, and ..
  60. Linda M Graham; Fiscal Year: 2014
    ..which opens TRPC5 through a unique TRPC activation cascade, leading to a prolonged rise in intracellular free calcium ion concentration ([Ca2+]i)...
  61. David E Cohen; Fiscal Year: 2016
    ..be used to evaluate whether PC-TP, via the activity of Them2, exacerbates free fatty acid-induced depletion of calcium from the ER lumen...
  62. Alexandra M Machikas; Fiscal Year: 2014
    ..in the regulation of cell death via the mitochondrial permeability transition pore's (PTP) sensitivity to calcium overload, excess reactive oxygen species (ROS), and ATP depletion...
  63. CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2014
    ..including in vivo time-lapse 2 photon imaging, in vivo electrophysiological recordings of visual responses, calcium-imaging and behavior...
  64. Diet and the Calcium Channel TRPV6 in Colon Hyperplasia
    Sara Peleg; Fiscal Year: 2010
    ..and western life style that impair the microbial flora in the gut, such as diets high in fat and low in fiber and calcium. These factors combine to compromise the innate immunity of the gut and to increase the susceptibility to ..
  65. Dietary Factors Affecting Calcium and Zinc Absorption
    Steven Abrams; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant) [unreadable] We have conducted a series of studies to evaluate calcium and bone mineral status in children...
  66. NAD & CD38 Form a Communication System in the Retina
    Robert Miller; Fiscal Year: 2006
    ..Our working hypothesis is that cADPR and/or NAADP modulate the internal levels of calcium in Muller cells and that cADPR alters calcium through activation of ryanodine receptors...
  67. The Effect of PTHrP During Lactation
    John J Wysolmerski; Fiscal Year: 2010
    ..Newborns depend on milk for all nutrients, including calcium. Supplying enough calcium for milk production requires the mobilization of skeletal calcium in the mother, and ..
  68. CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE
    Cynthia Morris; Fiscal Year: 1990
    The importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators...
  69. OSTEOPOROSIS/DIHYDROXYVITAMIN REGULATED GENE EXPRESSION
    Sylvia Christakos; Fiscal Year: 1993
    ..to examine changes with aging in both male and female rats in the expression of two genes involved in intestinal calcium absorption and in vitamin D regulated renal handling of calcium; calbindin (the vitamin D- dependent calcium ..
  70. Synergistic effects of conjugated linoleic acid and calcium on bone mass
    Yeonhwa Park; Fiscal Year: 2009
    ..The main emphasis of prevention strategies has been on dietary calcium intake, however calcium by itself has limited efficacy...
  71. Claudin-2, Claudin-12 and Cadherin-17: Novel Targets of Vitamin D Action
    ANGELA R PORTA; Fiscal Year: 2011
    ..by applicant): The object of this proposal is to obtain a better understanding of vitamin D action on intestinal calcium transport...
  72. Calcium Absorption and Bone Formation During Puberty
    Steven Abrams; Fiscal Year: 2005
    ..Scanned from the applicant's abstract) Background: Rapid increases in bone mass occur during Liberty Optimizing calcium absorption (Ca abs) and bone calcium deposition (V0+) during puberty can enhance peak bone mass and ultimately ..
  73. Calcium, Vitamin D, and Markers of Adenomatous Polyps
    Roberd Bostick; Fiscal Year: 2006
    ..is strong biological plausibility and animal experimental evidence for protection against colorectal cancer by calcium and vitamin D, calcium significantly reduced adenoma recurrence in a large clinical trial in humans (yet the ..
  74. BILE ACIDS AND HEPATOCELLULAR SIGNAL TRANSDUCTION
    Bernard Bouscarel; Fiscal Year: 1999
    The grant proposal of the PI is based on the significant role of hepatocellular calcium homeostasis in the maintenance of liver function...
  75. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the applicant's abstract) - Calcium is the single most important regulator of keratinocyte differentiation...