porphyrins

Summary

Summary: A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.

Top Publications

  1. ncbi Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
    Jonathan F Lovell
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5G 1L7, Canada
    Nat Mater 10:324-32. 2011
  2. ncbi Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
    Julian Leon Huppert
    Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge, UKCB3 0HE
    Chem Soc Rev 37:1375-84. 2008
  3. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
  4. ncbi Improvement of porphyrins for G-quadruplex DNA targeting
    Carmen Romera
    CNRS, Laboratoire de Chimie de Coordination, 205 route de Narbonne, Toulouse Cedex 4, France
    Biochimie 93:1310-7. 2011
  5. ncbi Structural basis for binding of porphyrin to human telomeres
    Gary N Parkinson
    CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Biochemistry 46:2390-7. 2007
  6. ncbi The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4
    Jeyaprakashnarayanan Seenisamy
    College of Pharmacy, The University of Arizona, 1703 East Mabel, Tucson, Arizona 85721, USA
    J Am Chem Soc 126:8702-9. 2004
  7. ncbi Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients
    W Stummer
    Department of Neurosurgery, Institute for Neuropathology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Neurosurg 93:1003-13. 2000
  8. ncbi Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase
    D F Shi
    College of Pharmacy, University of Texas at Austin, 78712, USA
    J Med Chem 44:4509-23. 2001
  9. ncbi Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy
    Aisling E O'Connor
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Photochem Photobiol 85:1053-74. 2009
  10. ncbi A spectroscopic study on the interactions of porphyrin with G-quadruplex DNAs
    Chunying Wei
    State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Biochemistry 45:6681-91. 2006

Detail Information

Publications344 found, 100 shown here

  1. ncbi Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
    Jonathan F Lovell
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5G 1L7, Canada
    Nat Mater 10:324-32. 2011
    ..The optical properties and biocompatibility of porphysomes demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy...
  2. ncbi Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
    Julian Leon Huppert
    Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge, UKCB3 0HE
    Chem Soc Rev 37:1375-84. 2008
    ..G-quadruplex structures are the subject of considerable interest for the development of small-molecule ligands, and are also the targets of a wide variety of natural proteins...
  3. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
    ....
  4. ncbi Improvement of porphyrins for G-quadruplex DNA targeting
    Carmen Romera
    CNRS, Laboratoire de Chimie de Coordination, 205 route de Narbonne, Toulouse Cedex 4, France
    Biochimie 93:1310-7. 2011
    ..acids was not found to provide clear additional molecular clues for G-quadruplex nucleic acids targeting by porphyrins tested in the present study...
  5. ncbi Structural basis for binding of porphyrin to human telomeres
    Gary N Parkinson
    CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Biochemistry 46:2390-7. 2007
    ..Implications for the design of quadruplex-binding ligands are discussed, together with a model for the formation of anaphase bridges, which are observed following cellular treatment with TMPyP4...
  6. ncbi The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4
    Jeyaprakashnarayanan Seenisamy
    College of Pharmacy, The University of Arizona, 1703 East Mabel, Tucson, Arizona 85721, USA
    J Am Chem Soc 126:8702-9. 2004
    ....
  7. ncbi Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients
    W Stummer
    Department of Neurosurgery, Institute for Neuropathology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Neurosurg 93:1003-13. 2000
    It has been established that 5-aminolevulinic acid (5-ALA) induces the accumulation of fluorescent porphyrins in glioblastoma multiforme (GBM), a phenomenon potentially exploitable to guide tumor resection...
  8. ncbi Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase
    D F Shi
    College of Pharmacy, University of Texas at Austin, 78712, USA
    J Med Chem 44:4509-23. 2001
    ..This SAR is consistent with a model presented for the complexation of TMPyP4 with human telomeric quadruplex DNA...
  9. ncbi Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy
    Aisling E O'Connor
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Photochem Photobiol 85:1053-74. 2009
    ..As a result, the requirement for new photosensitizers, including second generation porphyrins and porphyrin derivatives as well as third generation photosensitizers has arisen, with the aim of alleviating ..
  10. ncbi A spectroscopic study on the interactions of porphyrin with G-quadruplex DNAs
    Chunying Wei
    State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Biochemistry 45:6681-91. 2006
    ....
  11. ncbi Treatment of choroidal melanoma using photodynamic therapy
    Irene A Barbazetto
    E S Harkness Eye Institute, New York Presbyterian Hospital, Columbia University, New York, New York 10032, USA
    Am J Ophthalmol 135:898-9. 2003
    ..To InternetAdvance publication at ajo.com Feb 26, 2002. investigate the effect of photodynamic therapy using verteporfin on choroidal melanoma...
  12. ncbi Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes
    Luigi Martino
    Dipartimento di Chimica P Corradini, Universita degli Studi di Napoli Federico II, Via Cintia, I 80126, Napoli, Italy
    J Phys Chem B 113:14779-86. 2009
    ..This finding reinforces the potential applications of TMPyP4...
  13. ncbi Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines
    Yoko Mikami-Terao
    Department of Pediatrics, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Exp Eye Res 89:200-8. 2009
    ..This study provides insight into the molecular mechanism of the antitumor effects of TMPyP4. G-quadruplex structure may be a potential therapeutic target in retinoblastoma...
  14. ncbi Evidence for the binding mode of porphyrins to G-quadruplex DNA
    Chunying Wei
    Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China
    Phys Chem Chem Phys 11:4025-32. 2009
    ..58 x 10(6) and 1.24 x 10(7) M(-1) for parallel-stranded and antiparallel/parallel hybrid structures of AG(3)(T(2)AG(3))(3) G-quadruplex, respectively...
  15. ncbi Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light
    Helena Ashkenazi
    Health Sciences Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    FEMS Immunol Med Microbiol 35:17-24. 2003
    ..It is known to naturally produce high amounts of intracellular porphyrins. The results of the present study confirm that the investigated strain of P...
  16. ncbi Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles
    Andreas Fercher
    Biochemistry Department, University College Cork, Cavanagh Building, College Road, Cork, Ireland
    ACS Nano 5:5499-508. 2011
    ..High brightness and photostability allow its use in screening experiments with cell populations on a commercial TR-F reader, and for single cell analysis on a fluorescent microscope...
  17. ncbi Enhanced photodynamic activity of meso-tetra(4-hydroxyphenyl)porphyrin by incorporation into sub-200 nm nanoparticles
    Yvette Niamien Konan
    School of Pharmacy, University of Geneva, 30 quai E Ansermet, CH 1211 4, Geneva, Switzerland
    Eur J Pharm Sci 18:241-9. 2003
    ..The most important photocytotoxicity was observed with 50:50 PLGA nanoparticles allowing low drug doses and short drug administration-irradiation intervals for local photodynamic therapy...
  18. ncbi Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterization
    David N Zacks
    Retina Service and Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:2384-91. 2002
    ..To develop a model of verteporfin photodynamic therapy (PDT) for experimental choroidal neovascularization CNV in the rat...
  19. ncbi Intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy for choroidal neovascularization in age-related macular degeneration
    Bradley T Smith
    Barnes Retina Institute, St Louis, Missouri, USA
    Retina 28:675-81. 2008
    ..To report the outcome for eyes treated with intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy (PDT) for choroidal neovascularization (CNV) in age-related macular degeneration (AMD)...
  20. ncbi G-quadruplexes: targets in anticancer drug design
    Tian Miao Ou
    School of Pharmaceutical Science, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    ChemMedChem 3:690-713. 2008
    ..This review also covers research methodologies that have been developed to study the binding of ligands to G-quadruplexes...
  21. ncbi Differential biophysical behavior of human telomeric RNA and DNA quadruplex
    Amit Arora
    Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India
    J Phys Chem B 113:10515-20. 2009
    ..Our study provides a lead in extending the knowledge generated for the DNA quadruplex to the RNA level...
  22. ncbi Spectroscopic study on the binding of porphyrins to (G(4)T(4)G(4))4 parallel G-quadruplex
    Chunying Wei
    Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
    Biophys Chem 148:51-5. 2010
    ..05 x 10(6)M(-1) for (G(4)T(4)G(4))4-TPrPyP4, respectively. The two porphyrin molecules stack on the two ends of G-quadruplex with the higher binding affinity, another two porphyrins bind weakly to the two external grooves.
  23. pmc G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
    Susanna Cogoi
    Department of Biomedical Science and Technology, School of Medicine, P le Kolbe 4, 33100 Udine, Italy
    Nucleic Acids Res 34:2536-49. 2006
    ..Such a mechanism, which is probably adopted by other growth-related genes, provides useful hints for the rational design of anticancer drugs against the KRAS oncogene...
  24. ncbi Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
    Sayuri Taniguchi
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Biol Chem 280:7614-23. 2005
    ..Identification of small molecule inhibitors of heparin-induced assembly of tau will form a starting point for the development of mechanism-based therapies for the tauopathies...
  25. ncbi A prospective study of mercury toxicity biomarkers in autistic spectrum disorders
    David A Geier
    Institute of Chronic Illnesses, Silver Spring, Maryland, USA
    J Toxicol Environ Health A 70:1723-30. 2007
    b>Porphyrins are derivatives formed in the heme synthesis pathway and porphyrins afford a measure of xenobiotic exposure...
  26. pmc Hemoglobin-derived porphyrins preserved in a Middle Eocene blood-engorged mosquito
    Dale E Greenwalt
    Departments of Paleobiology and Mineral Sciences, National Museum of Natural History, Washington, DC 20013
    Proc Natl Acad Sci U S A 110:18496-500. 2013
    ..These data confirm the existence of taphonomic conditions conducive to the preservation of biomolecules through deep time and support previous reports of the existence of heme-derived porphyrins in terrestrial fossils.
  27. ncbi Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate
    Q Peng
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 62:140-5. 2001
    ..Both the distribution pattern and the amount of porphyrins in 32 lesions of 16 patients were studied after topical application of 16, 80 or 160 mg/g of methyl 5-..
  28. ncbi End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes
    Sarah E Evans
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    J Biol Inorg Chem 12:1235-49. 2007
    ..Consistent with our previous model for d(T(4)G(4)T(4)), we propose that two CuTMpyP4 molecules are externally stacked at each end of the run of guanines in all d(T(4)G( n )T(4)) (n = 4-10) quadruplexes...
  29. ncbi Photodynamic therapy with verteporfin for corneal neovascularization
    Kyung Chul Yoon
    Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea
    Am J Ophthalmol 144:390-395. 2007
    ..To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization...
  30. pmc Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action
    Karen Smith
    Department of Chemistry and Centre for Biomedical Research, University of Hull, Kingston upon Hull, UK
    Immunology 132:256-65. 2011
    Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized...
  31. ncbi Pd(II)-mediated assembly of porphyrin channels in bilayer membranes
    Usha Devi
    Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    Langmuir 27:1448-56. 2011
    ..Further studies suggested these Pd(II)/porphyrin oligomers transported 5/6-CF via a channel mechanism...
  32. ncbi Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure
    Jeyaprakashnarayanan Seenisamy
    College of Pharmacy, The University of Arizona, 1703 East Mabel, Tucson, Arizona 85721, USA
    J Am Chem Soc 127:2944-59. 2005
    Cationic porphyrins are known to bind to and stabilize different types of G-quadruplexes. Recent studies have shown the biological relevance of the intramolecular parallel G-quadruplex as a transcriptional silencer in the c-MYC promoter...
  33. ncbi Perylene anhydride fused porphyrins as near-infrared sensitizers for dye-sensitized solar cells
    Chongjun Jiao
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543
    Org Lett 13:3652-5. 2011
    Two perylene anhydride fused porphyrins 1 and 2 have been synthesized and employed successfully in dye-sensitized solar cells (DSCs)...
  34. ncbi Applications of liposomes in ophthalmology
    Shehab Ebrahim
    Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Surv Ophthalmol 50:167-82. 2005
    ..Although verteporfin is the only liposomal drug currently approved for use in the eye, the benefits of liposomes will likely be applied widely in all treatment, diagnostic, and research aspects of ophthalmology in the future...
  35. pmc Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly
    Cheng S Jin
    Ontario Cancer Institute, Campbell Family Cancer Research Institute and Techna Institute, University Health Network UHN, Toronto, Canada M5G 2M9
    ACS Nano 7:2541-50. 2013
    ..Using a novel hypoxia tumor model, we determined that nanostructured porphyrin PTT enhancers are advantageous to overcome hypoxic conditions to achieve effective ablation of solid tumors...
  36. ncbi Formation of a complex of 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)-21H,23H-porphyrin with G-quadruplex DNA
    Hajime Mita
    Department of Chemistry, University of Tsukuba, Tsukuba 305 8571, Japan
    Biochemistry 45:6765-72. 2006
    ..These findings provide novel insights for the design of porphyrin derivatives that bind to DNA with high affinity and specificity...
  37. pmc Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies
    Shiguang Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    PLoS ONE 8:e63682. 2013
    ....
  38. ncbi Chemically converted graphene induced molecular flattening of 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin and its application for optical detection of cadmium(II) ions
    Yuxi Xu
    Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, People s Republic of China
    J Am Chem Soc 131:13490-7. 2009
    ..On the basis of this phenomenon, we used the complex of TMPyP and CCG as an optical probe for rapid and selective detection of Cd(2+) ions in aqueous media...
  39. ncbi Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity
    Andrey A Rosenkranz
    Department of Molecular Genetics of Intracellular Transport, Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov St, 119334, Moscow, Russia
    FASEB J 17:1121-3. 2003
    ..The modular fusion proteins described here for the first time, capable of cell-specific targeting to particular subcellular compartments to increase drug efficacy, represent new pharmaceuticals with general application...
  40. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..e. porphyrins) are detrimental to Bcrp(-/-) cells under hypoxia...
  41. ncbi Water-soluble bis(imidazolylporphyrin) self-assemblies with large two-photon absorption cross sections as potential agents for photodynamic therapy
    Kazuya Ogawa
    Graduate School of Materials Science, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Med Chem 49:2276-83. 2006
    ..Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these newly prepared compounds are potential candidates as 2PA-photodynamic therapy agents...
  42. ncbi Two-photon absorption in tetraphenylporphycenes: are porphycenes better candidates than porphyrins for providing optimal optical properties for two-photon photodynamic therapy?
    Jacob Arnbjerg
    Department of Chemistry, University of Aarhus, DK 8000 Arhus, Denmark
    J Am Chem Soc 129:5188-99. 2007
    Porphycenes are structural isomers of porphyrins that have many unique properties and features...
  43. ncbi Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyes
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 240:748-57. 2002
    ..To determine the effects of photodynamic therapy (PDT) on choroidal and retinal structures of human eyes...
  44. ncbi Recognition of caffeine in aqueous solutions
    Roberto Fiammengo
    Laboratory of Supramolecular Chemistry and Technology MESA Research Institute, University of Twente, 7500 AE Enschede, The Netherlands
    Chemistry 9:784-92. 2003
    ..Receptors Zn-1 have also been investigated for the recognition of molecules structurally related to caffeine, for example, 1-methylimidazole. Selectivity towards oxopurine derivatives (caffeine and theophylline) have been found...
  45. ncbi Photodynamic therapy for lung cancers based on novel photodynamic diagnosis using talaporfin sodium (NPe6) and autofluorescence bronchoscopy
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
    Lung Cancer 58:317-23. 2007
    ..Recently, we established the autofluorescence diagnosis system integrated into a videoendoscope (SAFE-3000) as a very useful technique for the early diagnosis of lung cancer...
  46. ncbi Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides
    Ruslan I Dmitriev
    Biochemistry Department, University College Cork, Cavanagh Pharmacy Building, Cork, Ireland
    Anal Biochem 398:24-33. 2010
    ..They provide a simple and versatile tool for O(2) monitoring in live cells and in tissue, and an alternative to the existing O(2) probes which require facilitated transport into the cell...
  47. ncbi Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways >1.0 cm in diameter
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Clin Cancer Res 16:2198-204. 2010
    ..0 cm in diameter, which are assumed to involve extracartilaginous invasion and to be unsuitable for treatment with Photofrin-PDT...
  48. pmc Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses
    Haitao Guo
    Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 55:478-86. 2011
    ..The possible application of this family of compounds as antiviral agents, as microbicides and systemic virus neutralizing agents, is discussed...
  49. ncbi The binding mode of porphyrins with cation side arms to (TG4T)4 G-quadruplex: spectroscopic evidence
    Chunying Wei
    Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
    Biophys Chem 143:79-84. 2009
    ..one porphyrin molecule stacks on the one end of G-quadruplex with the higher binding affinity, another two porphyrins bind weakly to the two external grooves...
  50. ncbi Photodynamic therapy with verteporfin combined with subconjunctival injection of bevacizumab for corneal neovascularization
    In Cheon You
    Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea
    Cornea 30:30-3. 2011
    ..To investigate the efficacy of combined photodynamic therapy with verteporfin and subconjunctival injection of bevacizumab for the treatment of patients with corneal neovascularization...
  51. ncbi Ranibizumab for the treatment of neovascular age-related macular degeneration: a review
    Helen Kourlas
    Department of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA
    Clin Ther 29:1850-61. 2007
    ..The actions of ranibizumab result in reduced cell proliferation, reduced formation of new blood vessels, and minimization of vascular leakage...
  52. ncbi Combined treatment modalities for age related macular degeneration
    R A Das
    Selayang Eye Department, Hospital Selayang Batu Caves, Selangor, Malaysia
    Curr Drug Targets 12:182-9. 2011
    ..Age-related macular degeneration (AMD) is a condition that accounts for 75% of cases of legal blindness in individuals over the age of 50...
  53. ncbi Altered porphyrin excretion and histopathology of greylag geese (Anser anser) exposed to soil contaminated with lead and arsenic in the Guadalquivir Marshes, southwestern Spain
    Rafael Mateo
    Instituto de Investigación en Recursos Cinegéticos IREC, Consejo Superior de Investigaciones Cientificas Universidad de Castilla La Mancha Junta de Comunidades de Castilla la Mancha, Ronda de Toledo s n, 13005 Ciudad Real, Spain
    Environ Toxicol Chem 25:203-12. 2006
    ..to Pb, Zn, Cu, Mn, and As and to determine its relationship with soil ingestion and with the excretion of porphyrins and biliverdin as biomarkers...
  54. pmc Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer
    Imran Rizvi
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cancer Res 70:9319-28. 2010
    ..This approach combining biological modeling with high-content imaging provides a platform to rapidly screen therapeutic strategies for a broad array of metastatic tumors...
  55. ncbi A noninvasive thin film sensor for monitoring oxygen tension during in vitro cell culture
    Peter C Thomas
    Biochemical Science Division, National Institutes of Standard and Technology, Gaithersburg, Maryland 20899, USA
    Anal Chem 81:9239-46. 2009
    ..This sensor is likely to enable new studies on the effects of dissolved oxygen on cellular behavior...
  56. ncbi Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATX-s10 (Na)
    Shuji Ichinose
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Int J Oncol 29:349-55. 2006
    ..We conclude that lysosomal damage by ATX-s10-PDT can initiate apoptotic response and this apoptotic pathway can be regulated by photodamage to Bcl-2 via mitochondrial damage...
  57. ncbi Two-photon absorbing block copolymer as a nanocarrier for porphyrin: energy transfer and singlet oxygen generation in micellar aqueous solution
    Ching Yi Chen
    Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195 2120, USA
    J Am Chem Soc 129:7220-1. 2007
  58. ncbi Porphyrin, chlorin, and bacteriochlorin isothiocyanates: useful reagents for the synthesis of photoactive bioconjugates
    J M Sutton
    Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK
    Bioconjug Chem 13:249-63. 2002
    A novel method for conjugating porphyrins and related molecules to proteins has been developed...
  59. pmc ABA, porphyrins and plant TSPO-related protein
    Damien Guillaumot
    Institut des Sciences de la Vie, Molecular Physiology Group FYMO, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Plant Signal Behav 4:1087-90. 2009
    ..of AtTSPO, suggesting an inherent post-translational regulation mechanism also involving ABA and likely porphyrins. We present additional evidence that ABA can help stabilize constitutively expressed AtTSPO and that ALA feeding ..
  60. ncbi Spectroscopic STM studies of single gold(III) porphyrin molecules
    Stefan Müllegger
    Department of Solid State Physics and Institute of Inorganic Chemistry, Johannes Kepler University, Altenbergerstrasse 69, 4040 Linz, Austria
    J Am Chem Soc 131:17740-1. 2009
    ..AuTPP serves as a model system for chemotherapeutically relevant Au(III) porphyrins. For the first time, real-space images and local scanning tunneling spectroscopy data of the frontier molecular ..
  61. ncbi BDNF reduces the retinal toxicity of verteporfin photodynamic therapy
    Daniel M Paskowitz
    Department of Ophthalmology, University of California, San Francisco, 94143 0730, USA
    Invest Ophthalmol Vis Sci 45:4190-6. 2004
    ..In the current study, it was found that the neuroprotective agent brain-derived neurotrophic factor (BDNF) reduces this retinal damage...
  62. ncbi Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization
    Haicheng She
    Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 48:2268-77. 2007
    ..To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV)...
  63. ncbi Antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy can be enhanced by the use of a low dose of photofrin in human tumor xenografts
    Q Peng
    Department of Pathology, The Norwegian Radium Hospital, Institute for Cancer Research, University of Oslo, Montebello, 0310 Oslo, Norway
    Cancer Res 61:5824-32. 2001
    ..Although effective in tumor destruction, they also, unavoidably, induce phototoxicity of normal tissues. Porphyrins synthesized endogenously from 5-aminolevulinic acid (ALA) accumulate within cells...
  64. ncbi Stability and molecular recognition of quadruplexes with different loop length in the absence and presence of molecular crowding agents
    Amit Arora
    Institute of Genomics and Integrative Biology, CSIR, Delhi, India
    J Phys Chem B 113:8784-92. 2009
    ..The binding affinity (K(a)) of TMPyP4 was found to be decreased approximately by 1 order for the quadruplex sequences with total loop length varying from 11 to 15 in the presence of molecular crowding agents...
  65. ncbi Synthesis, photophysical properties, tumor uptake, and preliminary in vivo photosensitizing efficacy of a homologous series of 3-(1'-alkyloxy)ethyl-3-devinylpurpurin-18-N-alkylimides with variable lipophilicity
    G Zheng
    Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Med Chem 44:1540-59. 2001
    ..The mechanisms of the formation of the unexpected 12-formyl- and 12-(hydroxymethyl)purpurinimides under certain reaction conditions are also discussed...
  66. ncbi Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells
    Yoko Mikami-Terao
    Department of Pediatrics and Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer Lett 261:226-34. 2008
    ..These findings may provide a rationale for the development of guanine-quadruplex-interactive agents as novel antileukemic therapies...
  67. pmc TolC-dependent exclusion of porphyrins in Escherichia coli
    Ryoko Tatsumi
    Department of Bioengineering, Tokyo Institute of Technology, 4259 J2 14 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    J Bacteriol 190:6228-33. 2008
    ..that Escherichia coli tolC mutants showed increased sensitivity to 5-aminolevulinic acid (ALA), a precursor of porphyrins. The tolC mutant cells grown in the presence of ALA showed a reddish brown color under visible light and a ..
  68. pmc Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone
    Tomas Majtan
    Department of Pediatrics, University of Colorado, Denver, Aurora, Colorado 80045, USA
    J Biol Chem 283:34588-95. 2008
    ..Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme...
  69. pmc The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism
    Celine Vanhee
    Institute of Life Sciences, Molecular Physiology Group, Universite Catholique de Louvain, Croix du Sud 4 15, 1348 Louvain la Neuve, Belgium
    Plant Cell 23:785-805. 2011
    ..plant cell membrane protein, belongs to the TspO/MBR family of regulatory proteins, which can bind porphyrins. This work finds that boosting tetrapyrrole biosynthesis enhanced TSPO degradation in Arabidopsis thaliana and ..
  70. pmc The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA
    Noa Ofer
    Department of Biochemistry, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Nucleic Acids Res 37:2712-22. 2009
    ..Whereas low doses of TMPyP4, CBF-A or hnRNP A2 by themselves did not affect the in vivo utilization of (CGG)(99)-FL mRNA, introduction of TMPyP4 together with either protein synergistically augmented its translation efficiency...
  71. ncbi Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment--TAP and VIP report No. 2
    Irene Barbazetto
    Medizinische Universitat zu Lubeck, Klinik fur Augenheilkunde, Lubeck, Germany
    Arch Ophthalmol 121:1253-68. 2003
    ....
  72. ncbi Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins
    C J Gomer
    Clayton Ocular Oncology Center, Childrens Hospital Los Angeles, California 90027, USA
    Cancer Res 56:2355-60. 1996
    ....
  73. ncbi Fas ligand and TRAIL augment the effect of photodynamic therapy on the induction of apoptosis in JURKAT cells
    D J Granville
    QLT Inc, Vancouver, BC, Canada
    Int Immunopharmacol 1:1831-40. 2001
    ..For PDT, immune cell-mediated death receptor ligation may represent a way whereby tumor cells that have withstood the direct effects of photosensitization may be eliminated...
  74. ncbi Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnes
    S Ramstad
    Department of Physics, Norwegian University of Science and Technology, Dragvoll, Norway
    J Photochem Photobiol B 40:141-8. 1997
    ..It therefore appears that damage to membrane-associated components is at least partly responsible for [Ca2+]i alterations after photosensitization...
  75. ncbi Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung
    Harubumi Kato
    Department of Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 42:103-11. 2003
    ..PDT using the second generation photosensitizer NPe6 and a diode laser will likely become a standard modality of PDT for central type early superficial squamous cell carcinoma of the lung...
  76. ncbi Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston 02114 2698, USA
    Photochem Photobiol 75:51-7. 2002
    ..Our study points to the possible use of this methodology in the rapid control of wounds and other localized infections...
  77. ncbi Differential cytotoxic responses to low- and high-dose photodynamic therapy in human gastric and bladder cancer cells
    Je Ok Yoo
    Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Kangwon Do 200 701, Korea
    J Cell Biochem 112:3061-71. 2011
    ..Thus, these results demonstrate that LDP and HDP induced apoptotic and necrotic cell death by differential signaling mechanisms involving intracellular Ca(2+) , ROS, and TG2...
  78. ncbi Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins
    Janet K Kern
    Research Department, Genetics Consultants of Dallas ASD Centers, LLC, 408 N Allen Dr, Allen, TX 75013, USA
    Pediatr Int 53:147-53. 2011
    ..that children diagnosed with an autism spectrum disorder (ASD) have significantly increased levels of urinary porphyrins associated with mercury (Hg) toxicity, including pentacarboxyporphyrin (5cxP), precoproporphyrin (prcP), and ..
  79. ncbi Photodynamic therapy for exudative hamartoma in tuberous sclerosis
    Stefan Mennel
    Department of Ophthalmology, Philipps University, Marburg, Germany
    Arch Ophthalmol 124:597-9. 2006
  80. ncbi A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Toxicol Environ Health A 72:1585-91. 2009
    ..autism spectrum disorder (ASD) severity measured by Childhood Autism Rating Scale (CARS) scores and urinary porphyrins among a cohort of participants (n = 26)...
  81. pmc Photodynamic therapy-generated vaccines: relevance of tumour cell death expression
    M Korbelik
    Department of Cancer Imaging, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Br J Cancer 97:1381-7. 2007
    ..This opens attractive prospects for employing PDT vaccines tailored for individual patients targeting specific antigens of the patient's tumour...
  82. ncbi Identification of a mammalian mitochondrial porphyrin transporter
    Partha C Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Nature 443:586-9. 2006
    The movement of anionic porphyrins (for example, haem) across intracellular membranes is crucial to many biological processes, but their mitochondrial translocation and coordination with haem biosynthesis is not understood...
  83. ncbi The effect of photodynamic treatment combined with antibiotic action or host defence mechanisms on Staphylococcus aureus biofilms
    Antonella Di Poto
    University of Pavia, Department of Biochemistry, Viale Taramelli 3 b, Pavia 27100, Italy
    Biomaterials 30:3158-66. 2009
    ..The results suggest that PDT combined with vancomycin and the host defences may be a useful approach for the inactivation of staphylococcal biofilms adhering to medical implant surfaces...
  84. ncbi Benefits and complications of photodynamic therapy of papillary capillary hemangiomas
    Ursula M Schmidt-Erfurth
    Department of Ophthalmology, the University Eye Hospital, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Ophthalmology 109:1256-66. 2002
    ..To evaluate the potential benefit and risks of photodynamic therapy (PDT) in the treatment of papillary capillary hemangioma...
  85. pmc Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivative
    B A Allison
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Br J Cancer 69:833-9. 1994
    ..Thus, utilisation of this delivery system may provide for improvements in photodynamic therapy in clinical practice...
  86. ncbi Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion
    Gerardo Ferrer-Sueta
    Laboratorio de Fisicoquímica Biológica, Facultad de Ciencias, Universidad de la Republica, Montevideo 11400, Uruguay
    J Biol Chem 278:27432-8. 2003
    We have studied the reaction kinetics of ten manganese porphyrins, differing in their meso substituents, with peroxynitrite (ONOO-) and carbonate radical anion (CO3.) using stopped-flow and pulse radiolysis, respectively...
  87. ncbi Macrocyclic G-quadruplex ligands
    M C Nielsen
    Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark
    Curr Med Chem 17:3438-48. 2010
    ..These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments...
  88. ncbi DNA damage and apoptosis induced by photosensitization of 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin via singlet oxygen generation
    Saeko Tada-Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Photochem Photobiol 85:1391-9. 2009
    ..Taken together, the results demonstrated that TMPyP was localized in the nucleus where it was photosensitized to induce DNA damage, suggesting that TMPyP may have clinical utility as a nucleus-targeted PDT...
  89. pmc Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins
    John Lynch
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Cancer Res 69:5560-7. 2009
    The ATP-binding cassette (ABC) transporter ABCB6 localizes to the mitochondria, where it imports porphyrins and up-regulates de novo porphyrin synthesis...
  90. ncbi G-quadruplex DNA: a potential target for anti-cancer drug design
    H Han
    Arizona Cancer Center, Tucson, AZ 85724, USA
    Trends Pharmacol Sci 21:136-42. 2000
    ..The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article...
  91. pmc Mitochondrial release of apoptosis-inducing factor and cytochrome c during smooth muscle cell apoptosis
    D J Granville
    Department of Pathology and Laboratory Medicine, University of British Columbia McDonald Research Laboratories/The iCAPTURE Centre, St. Paul's Hospital/Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Pathol 159:305-11. 2001
    ....
  92. ncbi Antifungal photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    Microbiol Res 163:1-12. 2008
    ....
  93. ncbi Verteporfin PDT for non-standard indications--a review of current literature
    Wai Man Chan
    Department of Ophthalmology, HK Sanatorium Hospital, Happy Valley, Hong Kong
    Graefes Arch Clin Exp Ophthalmol 248:613-26. 2010
    ..We summarize current literature that has documented the use of verteporfin PDT in these conditions...
  94. ncbi Porphyrin precursors and porphyrins in three patients with acute intermittent porphyria and end-stage renal disease under different therapy regimes
    E Sardh
    Porphyria Centre Sweden, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Cell Mol Biol (Noisy-le-grand) 55:66-71. 2009
    Porphyrin precursors and porphyrins were measured in three patients with recurrent attacks of acute intermittent porphyria and end-stage renal disease (ESRD): two patients on hemodialysis and one on peritoneal dialysis...
  95. ncbi Photodynamic therapy for vasoproliferative retinal tumors
    Maria A Blasi
    Department of Ophthalmology, University of L Aquila, San Salvatore Hospital, Via Vetoio, 67100 Coppito, L Aquila, Italy
    Retina 26:404-9. 2006
    ..To report our experience with photodynamic therapy (PDT) with verteporfin for patients with vasoproliferative retinal tumors (VPRTs)...
  96. ncbi Photodynamic treatment in a rabbit model of glaucoma surgery
    Kalliopi Stasi
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Acta Ophthalmol Scand 84:661-6. 2006
    ..To evaluate the safety and efficacy of postoperative verteporfin photodynamic treatment as an adjunct to glaucoma experimental filtration surgery in rabbits...
  97. ncbi Contact transcleral photodynamic cyclo-suppression in human eyes: a feasibility study
    Spyridon K Charisis
    University Hospital of Heraklion, Department of Ophthalmology, Crete, Greece
    Can J Ophthalmol 46:196-8. 2011
    ..To evaluate the safety and efficacy of contact transcleral ciliary body photodynamic treatment (CB-PDT) with verteporfin in human eyes...
  98. pmc Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier
    Julio S Reboucas
    Department of Radiation Oncology, Duke University Medical School, Durham, NC 27710, USA
    Free Radic Biol Med 45:201-10. 2008
    Understanding the factors that determine the ability of Mn porphyrins to scavenge reactive species is essential for tuning their in vivo efficacy...
  99. ncbi Sewage bacteriophage inactivation by cationic porphyrins: influence of light parameters
    Liliana Costa
    CESAM and Department of Biology, University of Aveiro, Campus Universitario de Santiago, 3810 193, Aveiro, Portugal
    Photochem Photobiol Sci 9:1126-33. 2010
    ..In this way, the light source, fluence rate and total light dose play an important role in the effectiveness of the antimicrobial photodynamic therapy and should always be considered when establishing an optimal antimicrobial protocol...
  100. ncbi Mechanisms of photodynamic inactivation of a gram-negative recombinant bioluminescent bacterium by cationic porphyrins
    Anabela Tavares
    CESAM and Department of Biology, University of Aveiro, 3810 193, Aveiro, Portugal
    Photochem Photobiol Sci 10:1659-69. 2011
    ..the photoinactivation (PI) of a bioluminescent recombinant Escherichia coli, induced by three different cationic porphyrins, was identified in this work using a rapid method based on the monitoring of the metabolic activity of this ..
  101. ncbi Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy
    Yuichiro Hagiya
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    J Exp Ther Oncol 7:153-67. 2008
    ..Nrf2-specific siRNA treatments suppressed the induction of both ABCG2 and HO-1 after the photoactivation of porphyrins, suggesting that Nrf2 is a common regulator for transcriptional activation of the ABCG2 and HO-1 genes...

Research Grants65

  1. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..Specific aim #1 will determine if treating wildtype and HO-1 knockout mice with heme-like porphyrins or carbon monoxide decreases the binding of Rev-ERBa to the PGC1a promoter, a process that would stimulate ..
  2. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..MRI constructs utilize manganese(III) porphyrins. Strategies are adopted for attaching an optional third module to localize photoluminescence-based zinc sensors ..
  3. Molecular Probes of the Mechanisms of Cytocrhome P450
    JOHN TAYLOR GROVES; Fiscal Year: 2013
    ..We have discovered that some iron porphyrins are highly bioactive in suppressing protein nitration by peroxynitrite...
  4. Coupled Transfers of Electrons and Protons
    James M Mayer; Fiscal Year: 2013
    ..The systems to be examined include phenols, iron porphyrins, ruthenium complexes, and models for iron/sulfur cluster cofactors...
  5. Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome
    Ines Batinic-Haberle; Fiscal Year: 2013
    ..The potency of these compounds approaches that of SOD enzymes. Like SOD enzymes, Mn porphyrins suppress oxidative stress and excessive inflammation via direct reactions with reactive species (e.g., O2-, ...
  6. Structures and complexes of vertebrate telomere repeat DNAs.
    PHILIP BOLTON; Fiscal Year: 2009
    ..These studies include DNAs with more than one quadruplex unit since the effects of porphyrins may be to disrupt the interactions between quadruplex units. Specific Aim 3...
  7. BIOMEDICAL APPLICATIONS OF EXPANDED PORPHYRINS
    Alan B Watts; Fiscal Year: 2013
    ..Gadolinium(III) texaphyrins are a class of expanded porphyrins developed by the P.I. that have a clinically validated ability to localize selectively in tumors...
  8. Proton-Coupled Electron Transfer in Biomimetic and Natural Systems
    Daniel G Nocera; Fiscal Year: 2013
    ..The examination of how cofactor active sites are generated by PCET will be examined with hangman porphyrins, which are faithful structural and functional mimics of heme hydroperoxidase enzymes...
  9. 2010 Chemistry and Biology of Tetrapyrroles Gordon Research Conference
    Angela Wilks; Fiscal Year: 2010
    ..In addition important newresearch in the area of synthetic porphyrins as imaging and therapeutic molecules indiseases such as cancer will be presented.
  10. PORPHYRIN BIOSYNTHESIS IN NORMAL AND DISEASE STATES
    JOHN DEARBORN PHILLIPS; Fiscal Year: 2013
    ..We will also define the method used by cells to transfer porphyrins from the lysosome to the cytosol...
  11. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
    ..The potential of BNCT will only be realized if new and improved BNCT agents are discovered, synthesized and their properties thoroughly investigated. ..
  12. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    ..To study BR-sensitized degradation of copper-porphyrins under physiologic conditions and identify the products...
  13. De novo design of alpha-helical bundles
    William F Degrado; Fiscal Year: 2013
    ..for the design of a variety of helical bundles and b-proteins that encapsulate metal ions, homes, synthetic porphyrins, and linked porphyrin-quinone conjugates. Aim 3...
  14. Metalloprotein MRI Contrast Agent...for Targeted Imaging
    Zhan Wang; Fiscal Year: 2013
    ..As a complementary approach, we will also synthesize gadolinium(III) porphyrins for incorporation into BM3h...
  15. CYSTEINE THERAPY FOR ERYTHROPOIETIC PROTOPORPHYRIA
    MICHELINE MATHEWS ROTH; Fiscal Year: 1993
    ..shown to be very effective excited species quenchers, and in animal models, have prevented photosensitization by porphyrins: however, the ones studied are not approved for human use...
  16. HEME PROTEINS, MICROSPHERES AND SYNTHETIC ANALOGS
    KENNETH SUSLICK; Fiscal Year: 2004
    ..oxygen activation and hydrocarbon oxidation by metalloporphyrins, and the interactions between porphyrins as redox partners in organized media...
  17. BIOSYNTHETIC INTERMEDIATES OF PORPHYRINS
    Benjamin Frydman; Fiscal Year: 1990
    ..These studies are important in view of the fact that porphyrins and metalloporphyrins are increasingly being used as therapeutic, diagnostic and as phototherapeutic agents...
  18. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2009
    ..b>Porphyrins are important in anti-tumor therapies being developed...
  19. GORDON RESEARCH CONFERENCE ON PYRROLES
    SAMUEL BEALE; Fiscal Year: 1990
    ..Familiar pyrroles that have biological relevance include hemes, porphyrins, chlorophylls, bilins, and vitamin B12. Pyrroles are central to a number of human health areas...
  20. Transgenic porphyric Leishmania as suicidal live vaccines against leishmaniasis
    Kwang Poo Chang; Fiscal Year: 2007
    ..However, porphyrins formed in macrophages are metabolized rapidly to the background level, while those in Leishmania accumulate and ..
  21. PORPHYRINS AND QUINONES AS ENZYME COFACTORS
    THOMAS LOEHR; Fiscal Year: 1999
    ..vibrational spectroscopy, coupled with a vigorous synthetic model approach using novel, highly protected metallo-porphyrins that even stabilize an Fe-O2 adduct at room temperature...
  22. NORMAL AND ABNORMAL HEME BIOSYNTHESIS
    Timothy Lash; Fiscal Year: 1992
    ..All four of the pentacarboxylate porphyrins related to uroporphyrin-III will be synthesized and the action of coproporphyrinogen oxidase on the related ..
  23. TRANSITION METAL ORGANOIMIDO PORPHYRINS
    JOANNE SMIEJA; Fiscal Year: 1990
    ....
  24. UROPORPHYRINOGEN DECARBOXYLASE KNOCKOUT MOUSE
    RICHARD LAMBRECHT; Fiscal Year: 2001
    ..Patients with these diseases accumulate massively increased tissue levels of porphyrins, and consequently develop a variety of clinical symptoms...
  25. EFFECT OF LASER RADIATION ON PERIODONTOPATHIC BACTERIA
    CLAY HENRY; Fiscal Year: 1990
    ..laser radiation can be selectively toxic to black-pigmented Bacteroides: these bacteria possess endogenous porphyrins, which absorb laser radiation, transmitting that energy to acceptors, rendering them toxic...
  26. Heme Acquisition in Shigella Dysenteriae.
    Angela Wilks; Fiscal Year: 2005
    ..outer-membrane receptor (HutA) and the periplasmic binding protein (ShuT) will be determined with substituted porphyrins, with the premise that such data may provide templates for the development of small molecule inhibitors...
  27. MC5 RECEPTOR--REGULATION OF EXOCRINE GLAND FUNCTION
    ROGER CONE; Fiscal Year: 2003
    ..The MC5-R is also required for the production of porphyrins by the Harderian gland, and regulation of protein secretion by the lacrimal gland via the MC5-R...
  28. 3RD BIENNIAL MEETING--PHOTODYNAMIC ASSOCIATION
    Thomas Dougherty; Fiscal Year: 1990
    ..of the basic mechanisms of action, as well as the safety and efficacy of its clinical application using mainly porphyrins as sensitizers, the past several years have been characterized by a surge in the development of second ..
  29. IRON PORPHYRIN ACTIVATION OF DIOXYGEN/SMALL MOLECULES
    ALAN BALCH; Fiscal Year: 2004
    ..This project has recently discovered that iron porphyrins with a single meso substituent are remarkably sensitive to attack on the heme by O2...
  30. PROGRAM FOR DEVELOPMENT OF BNCT AGENTS
    Stephen B Kahl; Fiscal Year: 2010
    ..This program focuses on the synthesis and testing of boronated porphyrins as potential BNCT agents, making use of the fact that porphyrins are known to localize in solid tumors...
  31. APPROACHES TO DESIGNED METALLOPROTEINS
    David Benson; Fiscal Year: 2000
    ..Specific aims are to: 1) Prepare new helix-sandwiched porphyrins (HSP's) in order to more fully understand the factors which stabilize a-helices, particularly within the context ..
  32. ACTIVATION OF ANTI-CANCER AGENTS WITH ULTRASOUND
    Charles Cain; Fiscal Year: 1993
    ..In addition to hematoporphyrin, additional oxygen active compounds including other porphyrins, adriamycin, chlorins, phthalocyanines, bacteriochlorophylls, and cationic dyes, will be assayed for ultrasound ..
  33. Developing Mn Porphyrins as a Treatment for ALS
    Irwin Fridovich; Fiscal Year: 2006
    ..When tested in a murine model of FALS, by Dr. John Crow, one of our manganese porphyrins dramatically delayed paralysis and death (See preliminary data)...
  34. TRACE METAL ALTERATION OF RENAL PORPHYRIN METABOLISM
    James Woods; Fiscal Year: 1993
    ..These events promote oxidation of reduced porphyrins and peroxidation of cellular constituents, leading progressively to porphyria and cell injury, respectively...
  35. 2000 GORDON CONFERENCE ON TETRAPYRROLES
    Paul Ortiz de Montellano; Fiscal Year: 2000
    ..g. porphyrins, bilirubin, heme) is associated with numerous pathologies of the skin, liver and brain...
  36. RAMAN STUDIES OF PORPHYRINS/PROTEIN MAQUETTES/PROTEINS
    DAVID BOCIAN; Fiscal Year: 2003
    ..The first objective is (1) to elucidate the vibrational (and other) properties of phlorins (porphyrins with saturated methine positions) and hydrocorphinoids (porphyrins with saturated methine and beta-pyrrole ..
  37. 2006 Tetrapyrroles Chemistry and Biology of Gordon Research Conference
    Ann Smith; Fiscal Year: 2006
    ..But due to their photodynamic, toxic and lipophilic properties some tetrapyrroles (e.g. porphyrins, bilirubin) accumulate in cells of the skin, liver and brain, producing diverse pathologies (e.g. porphyrias)...
  38. ELECTRONIC STRUCTURE OF FERRIC PORPHYRINS
    CHARLES STROUSE; Fiscal Year: 1990
    ..crystal field effects in the determination of the spin distribution and electronic energies of low-spin ferric porphyrins. This situation is encountered in heme proteins when, for example, two axial imidazole ligands adopt nearly ..
  39. PHOTOSENSITIZERS IN MODEL MICROENVIRONMENTS
    Natalie Foster; Fiscal Year: 1990
    ..with micelles, reverse micelles and gel microemulsions, and (2) evaluating the distribution and reactivity of porphyrins in these microenvironments...
  40. EXCITED STATE DYNAMICS OF TRANSITION METAL PORPHYRINS
    Dewey Holten; Fiscal Year: 2000
    ..molecular structure, electron properties, and ground and excited state reactivity and relaxation dynamics of porphyrins and related ring systems...
  41. REDOX REACTIONS OF IRON PORPHYRINS
    KARL KADISH; Fiscal Year: 1991
    ..of the research project is to evaluate electron transfer reactivity of low, intermediate, and high spin iron porphyrins. Porphyrins with Fe(I), Fe(II), Fe(III), and Fe(IV) central metal ions will be investigated...
  42. NEW (B22H22)2 FOR NEUTRON CAPTURE AND DIAGNOSTICS
    BERNARD SPIELVOGEL; Fiscal Year: 1999
    ..polyhedral borane and carboranyl derivatives of biomolecules such as amino acids, nucleotides, nucleic acids, porphyrins, antibodies, etc. have been prepared as possible next generation BNCT agents...
  43. 2004 Tetrapyrroles Gordon Conference
    MARK O BRIAN; Fiscal Year: 2004
    ..Owing to their photodynamic activity, toxicity and lipophilicity, the accumulation of tetrapyrroles (e.g., porphyrins, bilirubin) is associated with numerous pathologies of the skin, liver and brain...
  44. PORPHYRIN INDUCED CA2+ RELEASE FROM SR
    JONATHAN ABRAMSON; Fiscal Year: 1990
    b>Porphyrins are prosthetic groups for a large number of biological molecules which carry out diverse roles in nature...
  45. Gordon Research Conference on Tetrapyrroles
    Gloria Ferreira; Fiscal Year: 2002
    ..Owing to their photodynamic activity, toxicity and lipophilicity, the accumulation of Tetrapyrroles (e.g., porphyrins, bilirubin) is associated with numerous pathologies of the skin, liver and brain...
  46. MASS SPECTROMETER FOR ORGANIC STRUCTURE DETERMINATION
    James Jackson; Fiscal Year: 1991
    ..Stille); (2) Studies in synthesis and functions of novel porphyrins and long-wavelength absorbing photosensitizers for photodynamic therapy (Dr...
  47. Supramolecular Porphyrin Based Catalysts and Sensors
    FRANCIS D SOUZA; Fiscal Year: 2001
    ..Homonuclear porphyrin dimers, such as Co-Co, Fe-Fe or Mn-Mn will be prepared by using water soluble porphyrins bearing different charges on peripheral substituents...
  48. Quantifying Biosynthesized Porphyrins and Complexes
    MARK SCHLAUTMAN; Fiscal Year: 2004
    ..is that fast, simple and inexpensive methodologies can be developed to quantify low-level concentrations of porphyrins and porphyrin-metal complexes found in organisms by improving photophysical (e.g...
  49. PORPHYRINS AS MICROBICIDES FOR PREVENTION OF STDS/HIV
    Richard Compans; Fiscal Year: 2003
    ..Luigi Marzilli and Dabney Dixon will synthesize, purify, and characterize porphyrins and metalloporphyrins for biological studies in projects and will support the biological studies with ..
  50. NADH FLUORESCENCE IMAGING IN HEART
    CLYDE BARLOW; Fiscal Year: 1990
    ..that an enhanced instrument can produce complimentary images of tissue oxygen tension using unique palladium porphyrins. Phase II will consist of: (1) upgrading the videofluorometer to obtain sequential NADH and palladium porphyrin ..
  51. Hangman Metalloporphyrins as Heme Hydroperoxidase Models
    JAKE SOPER; Fiscal Year: 2004
    ..Recently, a methodology for the preparation of "Hangman" porphyrins was developed. This architecture positions an acid-base group above an oxidizing active site via a rigid spacer...
  52. NERVOUS SYSTEM PORPHYRINS AND LEAD AND PCB EFFECTS
    William Whetsell; Fiscal Year: 1980
    ..In mature cultures treated with chlorinated hydrocarbons (polychlorinated biphenyls-PCB's), biochemical and morphological effects will be studied in relationship to nervous system porphyrin-heme pathways...
  53. Synthesis of a Fluorescent Sensor for Nitric Oxide
    Matthew Clark; Fiscal Year: 2003
    ..The short term aims are: to develop efficient syntheses of soluble porphyrins with a single linking site; to synthesize linkable fluorescein derivatives containing a Lewis basic site for ..
  54. Biosynthesis of Unnatural Porphyrins in E. Coli
    Claudia Schmidt Dannert; Fiscal Year: 2005
    ..seek so to expand this approach to the biosynthesis of yet other, even more complex novel chemical compounds-porphyrins-demanding the development of new screening and analytical tools...
  55. HIGH RESOLUTION SPECTROSCOPY OF PORPHYRINS
    BORIS KIM; Fiscal Year: 1980
    ..Of particular interest in this project are the effects of impurity ligands on the spectra of porphyrins. A theoretical effort will be directed toward the calculation of the intensities of vibronic transitions...
  56. Fourier Transform Ion Cyclotron Resonance Mass Spect.
    Mehdi Moini; Fiscal Year: 2003
    ..single cell analysis, analysis of biological fluids at the endogenous level, biomedical applications of expanded porphyrins, cell metabolism in normal vs...
  57. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  58. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  59. Vacsular Remodeling and Effects of Angiogenic Inhibition in Diabetic Retinopathy
    Peter Kaiser; Fiscal Year: 2006
    ..The CAM continues to serve as a convenient testbed for ongoing development of fractal methods and for examination of effects of human regulators on angiogenesis and vascular remodeling. ..
  60. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  61. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  62. Glutathione transport, oxidative stress and lung injury
    Brian Day; Fiscal Year: 2007
    ..air pollutants in sensitive populations with pre-existing lung disease, since a large number of pulmonary diseases (including COPD, ARDS, asthma and pulmonary fibrosis) also have deficits pulmonary ELF GSH [unreadable] [unreadable]..
  63. Role of Oxidatve Stress in Chronic Beryllium Disease
    Brian Day; Fiscal Year: 2006
    ..These studies have the potential to further define the etiology of CBD, risk factors, and suggest novel approaches to prevent and treat this disease. ..
  64. Medicinal Inorganic Chemistry ACS Symposium F-2003
    Jonathan Sessler; Fiscal Year: 2003
    ..It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission. ..
  65. Oligopyrrole-based Anion Binding Agents
    Jonathan L Sessler; Fiscal Year: 2010
    ..abstract_text> ..