oligoclonal bands

Summary

Summary: Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.

Top Publications

  1. ncbi Cerebrospinal fluid analysis in the diagnosis of multiple sclerosis
    Edward J Thompson
    Department of Neuroimmunology, National Hospital for Neurology and Neurosurgery, Queen Square, London, Ontario, Canada
    Adv Neurol 98:147-60. 2006
  2. ncbi The clinical significance of an intrathecal monoclonal immunoglobulin band: a follow-up study
    Gerard Davies
    Department of Neuroinflammation, Institute of Neurology, University College London
    Neurology 60:1163-6. 2003
  3. ncbi Multiple sclerosis and occult gluten sensitivity
    Marios Hadjivassiliou
    Neurology 64:933-4; author reply 933-4. 2005
  4. ncbi Unusual association of multiple sclerosis with monoclonal gammopathy of undetermined significance (MGUS): two case reports
    Michael Rentzos
    Department of Neurology, Aeginition Hospital Athens Medical School, Athens, Greece
    Funct Neurol 19:253-6. 2004
  5. ncbi Clinical and laboratory features of in-patients with multiple sclerosis in a University Hospital in Tokyo from 1988-2002
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, Shinanomachi, Tokyo
    Intern Med 44:560-6. 2005
  6. ncbi The prognostic significance of cerebrospinal fluid in multiple sclerosis
    Sasitorn Siritho
    The Ottawa Hospital, General Campus, 4th Floor, Multiple Sclerosis Research Unit, Ottawa, ON, Canada
    J Neurol Sci 279:21-5. 2009
  7. ncbi Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    Hans Link
    Karolinska Institute, 14185 Stockholm, Sweden
    J Neuroimmunol 180:17-28. 2006
  8. ncbi Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude
    Ruth Dobson
    Blizard Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    J Neurol Neurosurg Psychiatry 84:909-14. 2013
  9. ncbi Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort
    L Romero-Pinel
    Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Eur J Neurol 18:1258-62. 2011
  10. ncbi Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    M Tintore
    Unit of Clinical Neuroimmunology, Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurology 70:1079-83. 2008

Detail Information

Publications216 found, 100 shown here

  1. ncbi Cerebrospinal fluid analysis in the diagnosis of multiple sclerosis
    Edward J Thompson
    Department of Neuroimmunology, National Hospital for Neurology and Neurosurgery, Queen Square, London, Ontario, Canada
    Adv Neurol 98:147-60. 2006
  2. ncbi The clinical significance of an intrathecal monoclonal immunoglobulin band: a follow-up study
    Gerard Davies
    Department of Neuroinflammation, Institute of Neurology, University College London
    Neurology 60:1163-6. 2003
    ..At present, it is not known whether a single band will convert to an oligoclonal response with time...
  3. ncbi Multiple sclerosis and occult gluten sensitivity
    Marios Hadjivassiliou
    Neurology 64:933-4; author reply 933-4. 2005
  4. ncbi Unusual association of multiple sclerosis with monoclonal gammopathy of undetermined significance (MGUS): two case reports
    Michael Rentzos
    Department of Neurology, Aeginition Hospital Athens Medical School, Athens, Greece
    Funct Neurol 19:253-6. 2004
    ..This association is very unusual and it is not certain whether the co-occurrence of these disorders might be the result of a causal link between multiple sclerosis and monoclonal gammopathy or a fortuitous phenomenon...
  5. ncbi Clinical and laboratory features of in-patients with multiple sclerosis in a University Hospital in Tokyo from 1988-2002
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, Shinanomachi, Tokyo
    Intern Med 44:560-6. 2005
    ..The aim of this study was to analyze the clinical and laboratory features of each subtype of multiple sclerosis (MS) (relapsing-remitting, primary progressive, and secondary progressive) in the Tokyo metropolitan area...
  6. ncbi The prognostic significance of cerebrospinal fluid in multiple sclerosis
    Sasitorn Siritho
    The Ottawa Hospital, General Campus, 4th Floor, Multiple Sclerosis Research Unit, Ottawa, ON, Canada
    J Neurol Sci 279:21-5. 2009
    Multiple Sclerosis (MS) patients lacking CSF oligoclonal bands are purported to have a milder course of disease. We reviewed the natural history of oligoclonal band (OCB) - negative (OCB-) compared to OCB positive (OCB+) patients.
  7. ncbi Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    Hans Link
    Karolinska Institute, 14185 Stockholm, Sweden
    J Neuroimmunol 180:17-28. 2006
    ..systemic B-cell responses in patients with MS or CIS vs. patients with other inflammatory neurological diseases should shed new light on the role of CSF OB, which remains enigmatic...
  8. ncbi Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude
    Ruth Dobson
    Blizard Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    J Neurol Neurosurg Psychiatry 84:909-14. 2013
    b>Oligoclonal bands (OCBs) unique to the cerebrospinal fluid are used in the diagnosis of multiple sclerosis (MS). The precise prevalence of OCBs in MS and clinically isolated syndrome (CIS) is unknown...
  9. ncbi Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort
    L Romero-Pinel
    Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Eur J Neurol 18:1258-62. 2011
    ..This study investigated the association between HLA-DRB1 alleles and the presence of oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid (CSF) in a Spanish population with MS...
  10. ncbi Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    M Tintore
    Unit of Clinical Neuroimmunology, Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurology 70:1079-83. 2008
    To evaluate whether oligoclonal bands (OB) add information to MRI in predicting both a second attack and development of disability in patients with clinically isolated syndromes (CIS).
  11. ncbi Idiopathic acute transverse myelitis: application of the recent diagnostic criteria
    J de Seze
    Department of Neurology, University of Lille, France
    Neurology 65:1950-3. 2005
    ..In a retrospective study of 288 patients with ATM, 45 cases (15.6%) met the criteria for idiopathic ATM. The patients formed a relatively homogeneous group in terms of clinical and MRI data, but the prognosis was highly variable...
  12. ncbi Multiple sclerosis with and without CSF bands: clinically indistinguishable but immunogenetically distinct
    Kerstin Imrell
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:1062-4. 2006
    We sought to determine whether Swedish patients with multiple sclerosis (MS) with and without oligoclonal bands (OCBs) in the CSF constitute distinct subpopulations, clinically and immunogenetically...
  13. ncbi CSF oligoclonal band status informs prognosis in multiple sclerosis: a case control study of 100 patients
    F G Joseph
    University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK
    J Neurol Neurosurg Psychiatry 80:292-6. 2009
    ..The study hypothesis was that a definitive study would not only be of clinical and prognostic value but also potentially offer information about the possible role of CSF oligoclonal immunoglobulins in MS disease processes...
  14. ncbi Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-beta
    Pasquale Annunziata
    Department of Neurological Sciences and Behaviour, University of Siena, Italy
    J Neurol Sci 244:97-102. 2006
    To assess the role of CSF oligoclonal bands (OB) in determining the clinical outcome in patients with relapsing-remitting multiple sclerosis (RRMS) treated with IFN-beta, we carried out a retrospective, multicentre, observational study ..
  15. ncbi HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands. Human leukocyte antigen
    S Kikuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurology 60:647-51. 2003
    ....
  16. ncbi The significance of oligoclonal bands in multiple sclerosis in Japan: relevance of immunogenetic backgrounds
    T Fukazawa
    Hokuyukai Neurology Hospital, Sapporo, Japan
    J Neurol Sci 158:209-14. 1998
    ..Further investigations involving more patients are warranted...
  17. ncbi The significance of oligoclonal bands in multiple sclerosis: relevance of demographic and clinical features, and immunogenetic backgrounds
    Egemen Idiman
    Dokuz Eylul University, Faculty of Medicine, Department of Neurology, Balcova, Izmir, Turkey
    J Neuroimmunol 212:121-4. 2009
    ..007) and control group (p=0.0002). In conclusion, our results suggested that, MS patients with CSF OCBs have a female predominance, better clinical course with less disability and better prognosis, are associated with HLA-DR15...
  18. ncbi Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort
    Jing Shan Wu
    Australian Neuromuscular Research Institute, Sir Charles Gairdner Hospital, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, 6009, Perth, WA, Australia
    J Neurol Sci 288:63-7. 2010
    ..Our study is the first to show that HLA-DRB1 allele interactions and dose-effects influence the frequency of OCB...
  19. ncbi Brain atrophy and lesion load are related to CSF lipid-specific IgM oligoclonal bands in clinically isolated syndromes
    María José Magraner
    Multiple Sclerosis Unit, Neurology Department, Hospital La Fe, Av Campanar 21, Valencia, 46009, Spain
    Neuroradiology 54:5-12. 2012
    ....
  20. ncbi Cerebrospinal fluid oligoclonal bands and progression of disability in multiple sclerosis
    M Koch
    Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Neurol 14:797-800. 2007
    ..The majority of patients with MS have oligoclonal bands (OCB), corresponding to antibodies against a variety of antigens, in their cerebrospinal fluid (CSF)...
  21. ncbi Cerebrospinal fluid parameters of B cell-related activity in patients with active disease during natalizumab therapy
    A Harrer
    Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Austria
    Mult Scler 19:1209-12. 2013
    Recently, the disappearance of oligoclonal bands (OCBs) from the cerebrospinal fluid (CSF) of a few natalizumab-treated patients with multiple sclerosis (MS) has been reported...
  22. ncbi Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition
    Carlos Fernández de Larrea
    Departments of Hematology, Hospital Clinic, Barcelona and Institut d Investigacions Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain
    Blood 114:4954-6. 2009
    ..2%) showed an abnormal FLC ratio. The frequency of abnormal FLC ratio in patients with or without oligoclonal bands was 72.7% versus 26%, respectively (P = .023). The median value of FLC ratio was 2...
  23. ncbi Oligoclonal bands and antibody responses in multiple sclerosis
    Jorge Correale
    Departmento de Neurologia, Instituto de Investigaciones Neurológicas, Dr Raúl Carrea, Buenos Aires, Argentina
    J Neurol 249:375-89. 2002
    ..The introduction of more sensitive procedures for protein detection has allowed demonstrating oligoclonal bands (OCBs) in up to 95 % of patients with clinically definite MS...
  24. ncbi The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands
    I Bosca
    Neurology Department, Hospital La Fe, Valencia, Spain
    J Neuroimmunol 226:143-6. 2010
    ..4-fold compared to having only OC-IgG. Median time to second relapse was 0.7 years for patients with OC-IgG+LS-OC-IgM and 3.3 years for those with only OC-IgG. Therefore, CSF analysis identifies CIS patients at risk of second relapse...
  25. ncbi Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression
    Pedro Lourenco
    Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Mult Scler 19:577-84. 2013
    The use of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) parameters are established in the diagnosis of MS, but poorly as markers of disease.
  26. pmc Oligoclonal bands in the cerebrospinal fluid of amyotrophic lateral sclerosis patients with disease-associated mutations
    Nicola Ticozzi
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy
    J Neurol 260:85-92. 2013
    ..This study investigates the occurrence of oligoclonal bands (OCBs) in the CSF of a large series of ALS patients, attempting a correlation with genotype data...
  27. ncbi Prospective study of patients presenting with acute partial transverse myelopathy
    C Cordonnier
    Dept of Neurology, CHRU de Lille, Lille, France
    J Neurol 250:1447-52. 2003
    ..Nevertheless, it remains difficult for the clinician to ascertain conversion to MS after a first episode of acute partial transverse myelopathy (APTM)...
  28. pmc Emergence of oligoclonal bands in patients with multiple myeloma in complete remission after induction chemotherapy: association with the use of novel agents
    Carlos Fernández de Larrea
    Departments of Hematology, Servei d Hematologia, Hospital Clinic de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Haematologica 96:171-3. 2011
    The emergence of oligoclonal bands is associated with a favorable outcome after autologous stem cell transplantation in multiple myeloma...
  29. ncbi Comparison of two methods for the detection of oligoclonal bands in a large number of clinically isolated syndrome and multiple sclerosis patients
    Aljoša Andlovic
    Department of Neurology, Medical Centre, Ljubljana, Slovenia
    Clin Neurol Neurosurg 114:659-62. 2012
    ..It also accurately predicted conversion to MS in patients with CIS. The aim of our study was to compare sensitivity of a novel and the standard procedure with peroxidase immunodetection in a large number of CIS and MS patients...
  30. ncbi Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands in cerebrospinal fluid
    Jussi O Virtanen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Neuroimmunol 237:93-7. 2011
    ..of the central nervous system (CNS) often include elevated IgG production in intrathecal space presenting as oligoclonal bands (OCBs) in cerebrospinal fluid (CSF). In most demyelinating diseases, e.g...
  31. ncbi Acute transverse myelitis with normal brain MRI : long-term risk of MS
    Jui Perumal
    Multiple Sclerosis Center, Dept of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Neurol 255:89-93. 2008
    ..To investigate the long-term risk of developing MS in patients presenting with acute transverse myelitis (ATM) and normal brain MRI scans at onset...
  32. ncbi Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases
    Diego Franciotta
    Laboratory of Neuroimmunology, IRCCS National Neurological Institute C Mondino, University of Pavia, Italy
    J Neuroimmunol 230:160-3. 2011
    ....
  33. ncbi Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid are less likely to develop neutralizing antibodies against interferon beta
    M Lundkvist
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mult Scler 16:796-800. 2010
    ..46%). We propose that oligoclonal IgG band-negative patients differ immunologically from oligoclonal IgG band-positive patients, potentially influenced by distinct HLA-DRB1 alleles...
  34. ncbi The significance of HLA DRB1*1501 and oligoclonal bands in multiple sclerosis: clinical features and disability
    Renata Balnytė
    Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
    Medicina (Kaunas) 47:368-73. 2011
    ..The aim of the present study was to determine the value of immunogenetic risk factors and to estimate their relationship with the clinical features and disability status of patients with multiple sclerosis in a Lithuanian population...
  35. ncbi HLA-DRB115 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis
    Kerstin Imrell
    Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Neuroimmunol 210:128-30. 2009
    ..0. Both carriage of HLA-DRB1*15 and the presence of OCB hastened attainment of EDSS 6.0...
  36. ncbi Cerebrospinal fluid oligoclonal bands in childhood opsoclonus-myoclonus
    Michael R Pranzatelli
    Division of Child and Adolescent Neurology, Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9643, USA
    Pediatr Neurol 45:27-33. 2011
    b>Oligoclonal bands in cerebrospinal fluid reflect local B-cell responses associated with various neuroinflammatory disorders...
  37. ncbi Oligoclonal bands and MRI in clinically isolated syndromes: predicting conversion time to multiple sclerosis
    Rojas Juan Ignacio
    MS Section, Neurology Department, Italian Hospital of Buenos Aires, Gascon 450, Buenos Aires, Argentina
    J Neurol 257:1188-91. 2010
    The objective of the study was to evaluate whether the presence of oligoclonal bands (OB) adds information in predicting CIS conversion to clinical definite multiple sclerosis (CDMS) and conversion time to CDMS...
  38. ncbi Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: results from 211 lumbar punctures
    S Jarius
    Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Germany
    J Neurol Sci 306:82-90. 2011
    ..AQP4-Ab positive NMO is now considered an immunopathogenetically distinct disease in its own right. However, to date little is known about the cerebrospinal fluid (CSF) in AQP4-Ab positive NMO...
  39. ncbi Paediatric and adult multiple sclerosis: age-related differences and time course of the neuroimmunological response in cerebrospinal fluid
    H Reiber
    Neurochemistry Laboratory, Department of Neurology, University Göttingen, Germany
    Mult Scler 15:1466-80. 2009
    ..CSF analysis may help to discriminate between acute and mono-symptomatic chronic inflammatory disease already at earliest clinical manifestation...
  40. ncbi Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis
    T Matsuoka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mult Scler 14:1181-90. 2008
    ..We aimed to disclose possible factors contributing to the development of such MRI features...
  41. ncbi Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis
    Birgit Obermeier
    Institute of Clinical Neuroimmunology, Ludwig Maximilians University, University Hospital Grosshadern, Marchioninistrasse 15, D 81377 Munich, Germany
    Nat Med 14:688-93. 2008
    ..This approach can be applied to other organ-specific diagnostic fluid or tissue samples to compare the Ig transcripts of local B cells with the corresponding antibody proteomes of individual subjects...
  42. ncbi A multifactorial prognostic index in multiple sclerosis. Cerebrospinal fluid IgM oligoclonal bands and clinical features to predict the evolution of the disease
    Jessica Mandrioli
    Clinica Neurologica, Dept of Neuroscience, University of Modena and Reggio Emilia, Nuovo Ospedale Civile S Agostino Estense di Modena, Via Giardini 1355, 41100 Modena, Italy
    J Neurol 255:1023-31. 2008
    ..The aim of the study was to create a multifactorial prognostic index (MPI) providing the probability of a severe MS course at diagnosis based on clinical and immunological CSF parameters...
  43. ncbi The prevalence of oligoclonal bands in the CSF of patients with primary neurodegenerative dementia
    J C Janssen
    Dementia Research Group, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    J Neurol 251:184-8. 2004
    ..that younger patients with dementia should undergo CSF examination, which frequently includes analysis for oligoclonal bands (OCB)...
  44. ncbi Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis: differences in repeated cerebrospinal fluid examinations
    R Bergamaschi
    Centre for Multiple Sclerosis, Neurological Institute IRCCS C Mondino, University of Pavia, Pavia, Italy
    Mult Scler 10:2-4. 2004
    ..Variations of oligoclonal bands (OBs) had opposite trends in the two groups...
  45. ncbi The discovery of oligoclonal bands: a 50-year anniversary
    Trygve Holmøy
    Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo University Hospital Rikshospitalet and Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    Eur Neurol 62:311-5. 2009
    ..The discovery of OCB led to the still prevailing concept that MS is mediated by clonally expanded lymphocytes, and provided the basis for modern diagnostic procedures in MS...
  46. ncbi Isolated demyelinating syndromes: comparison of CSF oligoclonal bands and different MR imaging criteria to predict conversion to CDMS
    M Tintore
    Unit of Clinical Neuroimmunology Department of Neurology, Vall d Hebron University Hospitals, Barcelona, Spain
    Mult Scler 7:359-63. 2001
    To evaluate and compare the capacity of oligoclonal bands (OB) and three sets of MR imaging criteria to predict the conversion of clinically isolated syndromes (CIS) to clinically definite multiple sclerosis (CDMS).
  47. ncbi Oligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseases
    Diego Franciotta
    Laboratory of Neuroimmunology, IRCCS Neurological Institute C Mondino, Via Mondino 2, 27100 Pavia, Italy
    J Neuroimmunol 200:125-8. 2008
    ..These results indicate that CSF analysis can help differentiate between MS and ADEM and that, similarly to EAE, the 'mirror pattern' observed in ADEM accounts for a predominantly systemic immune activation...
  48. ncbi MRI criteria in MS patients with negative and positive oligoclonal bands: equal fulfillment of Barkhof's criteria but different lesion patterns
    Hagen B Huttner
    Department of Neurology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Neurol 256:1121-5. 2009
    In multiple sclerosis (MS) more than 95% of the patients have positive oligoclonal bands (OCB) in the cerebrospinal fluid (CSF)...
  49. ncbi Epstein-Barr virus nuclear antigen-1 (EBNA-1) associated oligoclonal bands in patients with multiple sclerosis
    K H Rand
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Florida, JHMHC, Box 199275, Gainesville, FL 32610 0275, USA
    J Neurol Sci 173:32-9. 2000
    b>Oligoclonal bands (OCBs) are frequently observed in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS), but the target antigens of these antibodies remain unknown...
  50. ncbi The contribution of cerebrospinal fluid oligoclonal bands to the early diagnosis of multiple sclerosis
    V Zipoli
    Department of Neurology, University of Florence, Florence, Italy
    Mult Scler 15:472-8. 2009
    ..McDonald Criteria (MDC) have been validated in selected patients at high risk for multiple sclerosis (MS). However, possible overdiagnosis of MS can represent critical issues in less controlled clinical settings...
  51. ncbi Analysis of Chlamydia pneumoniae-specific oligoclonal bands in multiple sclerosis and other neurologic diseases
    D Franciotta
    Laboratory of Neuroimmunology, IRCCS, Foundation Neurological Institute C Mondino, University of Pavia, Pavia, Italy
    Acta Neurol Scand 112:238-41. 2005
    Paired serum and cerebrospinal fluid (CSF) specimens were investigated for Chlamydia pneumoniae-specific oligoclonal bands (OCBs) to determine band specificity in multiple sclerosis (MS).
  52. ncbi Oligoclonal bands and immunoglobulin isotype switch during monitoring of patients with multiple myeloma and autologous hematopoietic cell transplantation: a 16-year experience
    Mariel Emilce Alejandre
    Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Clin Chem Lab Med 48:727-31. 2010
    ..During 16 years of follow-up, the degree of tumor response and survival in 238 patients with autologous stem cell transplantation (ASCT) and changes in the serum protein electrophoretic pattern were analyzed...
  53. ncbi B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation
    Edgar Meinl
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Munich, Germany
    Ann Neurol 59:880-92. 2006
    ..findings offer a plausible explanation for the notorious persistence and stability of cerebrospinal fluid oligoclonal bands. Furthermore, we highlight similarities and differences of intrathecal immunoglobulin production in multiple ..
  54. ncbi Antigen-specific oligoclonal bands in cerebrospinal fluid and serum from patients with anti-amphiphysin- and anti-CV2/CRMP5 associated paraneoplastic neurological syndromes
    O Stich
    Neurologische Klinik und Poliklinik der Albert Ludwigs Universitaet Freiburg, Freiburg, Germany
    Eur J Neurol 14:650-3. 2007
    ..blot preloaded with paraneoplastic antigen, we detected in three of four patients more or stronger specific oligoclonal bands (OCB) in the CSF than in the corresponding serum, providing qualitative evidence of antigen specific ..
  55. ncbi Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands"
    Hans Christian von Büdingen
    Dept of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
    J Neuroimmunol 218:134-9. 2010
    Clonally expanded plasma cells (cePC) and oligoclonal IgG (oligoclonal bands, OCB) in the cerebrospinal fluid (CSF) suggest an involvement of B cell mechanisms in autoimmune CNS demyelination...
  56. ncbi Assessment of outcome predictors in first-episode acute myelitis: a retrospective study of 53 cases
    Alberto Gajofatto
    Section of Clinical Neurology, Department of Neurological and Vision Sciences, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy
    Arch Neurol 67:724-30. 2010
    ..To identify predictors of short- and long-term outcomes in acute myelitis (AM)...
  57. ncbi Oligoclonal bands predict multiple sclerosis after optic neuritis: a literature survey
    A G Skov
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Mult Scler 17:404-10. 2011
    ..Cerebrospinal fluid from a patient with MS analysed by electrophoresis often shows a split to form so called oligoclonal bands (OCBs). OCBs consist of proteins from activated lymphocytes and plasma cell clones.
  58. ncbi MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS
    A Saiz
    Services of Neurology, , , University of Barcelona, Spain
    Neurology 56:1084-9. 2001
    OBJECTIVE: To analyze the MRI and CSF oligoclonal bands (OB) changes in patients with MS who underwent an autologous hematopoietic stem cell transplantation (AHSCT). BACKGROUND: AHSCT is evaluated as an alternative therapy in severe MS...
  59. ncbi Relevance of callosal and periventricular MRI lesions to oligoclonal bands in multiple sclerosis
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Seiryo machi, Sendai, Japan
    Acta Neurol Scand 113:125-31. 2006
    ..To evaluate the association between callosal or periventricular lesions, and the presence of oligoclonal IgG bands (OB) or the IgG index in Japanese patients with multiple sclerosis (MS)...
  60. ncbi CSF oligoclonal bands in MS include antibodies against Chlamydophila antigens
    S Y Yao
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neurology 56:1168-76. 2001
    ..Affinity-driven immunoblot studies and solid-phase adsorption of CSF oligoclonal bands by elementary body antigens of C pneumoniae, viral antigens (measles and herpes simplex virus-1), bacterial ..
  61. ncbi Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis
    Ichiro Nakashima
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Neuroimmunol 159:133-6. 2005
    ..When OSMS was excluded, the frequency increased to 77% by IEF, whereas it remained 23% by AGE. Our study strongly suggests that IEF is highly effective for detecting OB in Japanese MS patients...
  62. ncbi Oligoclonal bands measured in unconcentrated cerebrospinal fluid and other biochemical parameters in multiple sclerosis
    Jacek Kurzepa
    Chair and Department of Neurology, Skubiszewski Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 59:392-6. 2004
    ..Total protein level, white blood cells (WBC) count and presence of oligoclonal bands (OB) in CSF were examined...
  63. ncbi [Oligoclonal IgG bands in the cerebrospinal fluid of portuguese patients with multiple sclerosis: negative results indicate benign disease]
    Maria José Sá
    Head of Cerebrospinal Fluid CSF Unit, Head of Multiple Sclerosis MS Outpatient Clinical Care
    Arq Neuropsiquiatr 63:375-9. 2005
    ..We conclude that the frequency of positive IgG-OCB patterns in our MS patients fits most values reported in the literature, and that negative results indicate benign disease...
  64. ncbi Lack of serum oligoclonal antibody responses to Chlamydophila pneumoniae in multiple sclerosis
    M D Chapman
    Department of Neuroimmunology, Institute of Neurology, Great Ormond Street Hospital, London, UK
    Eur Neurol 53:81-3. 2005
    ..We undertook to investigate whether the presence of CSF oligoclonal IgG OCB or oligoclonal bands correlated with serum IgG raised against C. pneumoniae...
  65. ncbi Early differential diagnosis of multiple sclerosis using a new oligoclonal band test
    Luisa M Villar
    Department of Immunology, Hospital Ramon y Cajal, Madrid, Spain
    Arch Neurol 62:574-7. 2005
    ..Recently, we developed a new oligoclonal IgG band (OCGB) test for ITGS detection that is more sensitive and easier to interpret than previously described methods...
  66. ncbi Ankylosing spondylitis and multiple sclerosis in an HLA-B27 negative patient
    Funda Uysal Tan
    Kirikkale University, Faculty of Medicine, Department of Neurology, Kirikkale, Turkey
    Acta Neurol Belg 104:169-72. 2004
    ..MS) as the patient had insidious neurological progression, CSF evidence of inthrathecal production of oligoclonal bands, conduction defects at VEP, multiple brain and additional spinal cord lesions on MRI and continued ..
  67. ncbi Clinical correlations of CSF single IgG bands
    Diego Franciotta
    J Neurol 252:1274-5. 2005
  68. ncbi Increased intracranial pressure in a case of pediatric multiple sclerosis
    Brice J Williams
    Department of Neurosciences, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    J Child Neurol 23:699-702. 2008
    ..a diagnostic lumbar puncture showed significant intracranial hypertension in addition to numerous oligoclonal bands, elevated immunoglobulin G index and immunoglobulin G/albumin ratio in the cerebrospinal fluid...
  69. ncbi Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis
    N H Beyer
    Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
    Scand J Clin Lab Invest 67:696-706. 2007
    ..We investigated whether PAB serum status in acute monosymptomatic optic neuritis (ON) and MS differed significantly from that of healthy controls, and whether or not PAB status is predictive of later MS development in patients with ON...
  70. ncbi Intrathecal IgM-synthesis does not correlate with the risk of relapse in patients with a primary demyelinating event
    R Schneider
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany
    Eur J Neurol 14:907-11. 2007
    ..These data do not support the idea that the presence of IgM-OCB in CSF might predict an unfavourable course in MS...
  71. ncbi Interlaboratory reproducibility of isoelectric focusing in oligoclonal band detection
    Diego Franciotta
    Clin Chem 53:1557-8. 2007
  72. ncbi Higher IgG index found in African Americans versus Caucasians with multiple sclerosis
    John R Rinker
    Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO, USA
    Neurology 69:68-72. 2007
    ..Interethnic immunologic differences in MS and their relationship to disease-related disability have not been described...
  73. ncbi Clinical characteristics of patients with late-onset multiple sclerosis
    Bernhard Kis
    Dept of Neurology, Alfried Krupp Hospital, Essen, Germany
    J Neurol 255:697-702. 2008
    ..004). For individuals who develop LOMS, a primary progressive course is frequent, with motor symptoms as the prominent feature. Vigilance is necessary to recognise MS in this population because of its unusual presentation...
  74. ncbi Mitoxantrone for multiple sclerosis causing acute lymphoblastic leukemia
    M S Cartwright
    Wake Forest University School of Medicine, Department of Neurology, Winston Salem, NC 27157, USA
    Neurology 68:1630-1. 2007
  75. ncbi Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain
    J Qin
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Neurosci Res 85:977-84. 2007
    ..We therefore conclude that we can detect both OxPC and 15-kDa protein modified by OxPC and the antibody to the antibody to OxPC (antiidiotype) in pathological tissue and suggest that this could play a role in the progression of MS...
  76. ncbi Acute partial transverse myelitis: risk factors for conversion to multiple sclerosis
    J Sellner
    Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland corrected
    Eur J Neurol 15:398-405. 2008
    ..03) and lesions on brain MRI (P = 0.03) were predictive factors for conversion to MS. CSF-specific oligoclonal bands (P = 0.04) or abnormal IgG-index (P = 0.04) were associated with increased risk for MS as well...
  77. ncbi Intrathecal immunoglobulin G synthesis and brain injury by quantitative MRI in multiple sclerosis
    Carlos O Brandão
    Department of Microbiology and Immunology, Medical School, University of Campinas, Campinas, Brazil
    Neuroimmunomodulation 13:89-95. 2006
    ....
  78. ncbi Roles of immunoglobulins and B cells in multiple sclerosis: from pathogenesis to treatment
    Jack Antel
    Neuroimmunology Unit, Montreal Neurological Institute and McGill University, 3801 University Street, Room 111, Montreal, Quebec, Canada H3A2B4
    J Neuroimmunol 180:3-8. 2006
    ..Analysis of CSF Ig in terms of rate of production and restricted diversity (oligoclonal bands) remains a supportive diagnostic criteria for MS...
  79. ncbi Cerebrospinal fluid IgG profiles and oligoclonal bands in Chinese patients with multiple sclerosis
    B Li
    Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China
    Acta Neurol Scand 115:319-24. 2007
    To investigate the significance of oligoclonal bands (OCBs) and intrathecal IgG fractions (IgGIF) for the diagnosis of multiple sclerosis (MS) in northern China.
  80. ncbi CSF analysis in suspected MS: do bands aid?
    Rogier Q Hintzen
    Neurology 70:1059-60. 2008
  81. ncbi [Immunofixation compared to isoelectric focusing in the detection of oligoclonal bands in cerebrospinal fluid of multiple sclerosis patients]
    A Fromont
    Service de Neurologie, CHU, Dijon
    Rev Neurol (Paris) 161:1183-90. 2005
    Intrathecal immunoglobulins (Ig) synthesis, reflected by oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) is observed in up to 90 percent of patients with clinically definite Multiple Sclerosis (MS)...
  82. ncbi X-linked Charcot-Marie-Tooth disease and progressive-relapsing central demyelinating disease
    G Isoardo
    SOC Neurologia, Ospedale Civile di Asti, Asti, Italy
    Neurology 65:1672-3. 2005
  83. doi 10 most commonly asked questions about cerebrospinal fluid characteristics in demyelinating disorders of the central nervous system
    Matthias Mehling
    Department of Neurology, University Hospital, Basel, Switzerland
    Neurologist 14:60-5. 2008
  84. ncbi Between-laboratory variability in oligoclonal IgG band numbering
    Diego Franciotta
    Clin Chem 51:270-2. 2005
  85. ncbi [Clinical characteristics and neurophysiologic findings in patients with multiple sclerosis without oligoclonal IgG in cerebrospinal fluid]
    Sarlota Mesaros
    Institute of Neurology, Clinical Centre of Serbia, Belgrade
    Srp Arh Celok Lek 131:122-6. 2003
    ..This study was designed to compare clinical data and evoked potential (EP) findings between CSF OCB positive and OCB negative MS patients...
  86. ncbi [Magnetic resonance findings in the brain of patients with multiple sclerosis without oligoclonal bands in the cerebrospinal fluid]
    Sarlota Mesaroc
    Institute of Neurology, Clinical Center of Serbia, Belgrade
    Srp Arh Celok Lek 131:31-5. 2003
    ....
  87. ncbi The correlation between cerebrospinal fluid findings and evoked potentials during an acute MS attack
    C Irkec
    Gazi University Faculty of Medicine, Department of Neurology
    Electromyogr Clin Neurophysiol 41:117-22. 2001
    ..VEP, BAEP latencies were found to be prolonged as Ig G index increased. (p < 0.05) However the same correlation can not be found with SEP parameters...
  88. ncbi Relevance of immunological variables in neuroborreliosis and multiple sclerosis
    J Bednarova
    Department of Clinical Microbiology, Faculty Hospital, Masaryk University, Brno, Czech Republic
    Acta Neurol Scand 112:97-102. 2005
    ....
  89. ncbi Multiple sclerosis in Taiwan
    Ching Piao Tsai
    Neurology, The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:500-5. 2004
    ..The clinical features and prevalence of MS in Taiwan still remain to be clarified. The aim of this study was to determine the prevalence and delineate the clinical features of MS in Taiwanese patients...
  90. ncbi A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Mult Scler 8:459-62. 2002
    ..Our results suggest that the majority of OB-negative Japanese MS patents show either no or few brain MRI lesions or atypical brain MRI lesions...
  91. ncbi [Multiple sclerosis. Chlamydia hypothesis in debate]
    T Derfuss
    , , Am Klopferspitz 18a, 82152 Martinsried
    Nervenarzt 72:820-3. 2001
    ..involved in the pathogenesis of MS, one would expect that, in analogy to other infections of the CNS, the oligoclonal bands in the CSF of MS patients would recognize the responsible agent...
  92. ncbi Chlamydia pneumoniae in children with MS: frequency and quantity of intrathecal antibodies
    K Rostasy
    Department of Pediatric Neurology, University of Gottingen, Germany
    Neurology 61:125-8. 2003
    ....
  93. pmc High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis
    Richard A Nash
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 102:2364-72. 2003
    ..0 point EDSS) at 3 years was 27%. Of 12 patients who had oligoclonal bands in the cerebrospinal fluid at baseline, 9 had persistence after HDIT...
  94. ncbi Detection of oligoclonal immunoglobulins in cerebrospinal fluid by an immunofixation-peroxidase method
    Sophie Richard
    Laboratory of Immunology, Centre Hospitalier Regional et Universitaire de Bordeaux, 33076 Bordeaux, France
    Clin Chem 48:167-73. 2002
    ....
  95. ncbi [Contribution of biology to diagnosis of multiple sclerosis]
    R Liblau
    Laboratoire d'Immunologie Cellulaire et INSERM U 546, , Paris, France
    Rev Neurol (Paris) 157:963-7. 2001
    ..To date, no prognostic criteria can be drawn from the analysis of the CSF. Other biological tests can be performed in order to eliminate other diagnosis. These tests only have a great interest in atypical forms of the disease...
  96. ncbi CSF oligoclonal bands in multiple sclerosis
    I Siddiqui
    Department of Pathology, Aga Khan University, Karachi
    J Pak Med Assoc 52:351-3. 2002
    To study the significance of oligoclonal bands in neurological disorders, specifically in Multiple Sclerosis (MS).
  97. ncbi [Late onset multiple sclerosis]
    S Delalande
    Service de Neurologie D, Hopital Roger Salengro, CHRU Lille, 59037 Lille Cedex, France
    Rev Neurol (Paris) 158:1082-7. 2002
    ..This study highlights the differences between the late onset MS and earlier onset. As previously reported, our study underlines the high frequency of progressive course, motor function involvement and poor prognosis...
  98. ncbi Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis
    B Rostrom
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Acta Neurol Scand 109:106-12. 2004
    b>Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).
  99. pmc Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis
    S Goffette
    Service de Neurologie, Cliniques Universitaires Saint Luc, UCL, Brussels, Belgium
    J Neurol Neurosurg Psychiatry 75:308-10. 2004
    ..As such, they too are markers of an ongoing intrathecal immune process...
  100. ncbi CSF characteristics in early-onset multiple sclerosis
    D Pohl
    Department of Pediatrics and Pediatric Neurology, Georg August University Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Neurology 63:1966-7. 2004
    ..CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS...
  101. ncbi Paraneoplastic antibodies detected by isoelectric focusing of cerebrospinal fluid and serum
    Anette Storstein
    Department of Neurology, Haukeland University Hospital, N 5021, Bergen, Norway
    J Neuroimmunol 155:150-4. 2004
    ..employed isoelectric focusing and peroxidase-labeled anti-IgG or 35S-labeled Hu or Yo antigens to identify oligoclonal bands (OCB) representing either total IgG or Hu or Yo antibodies in serum and CSF of patients with paraneoplastic ..

Research Grants13

  1. The Role of Intrathecal Plasma Cell Clones in MS Pathogenesis
    GREGORY PARKS OWENS; Fiscal Year: 2013
    ..nature of disease are indicated by increased and persistent intrathecal IgG synthesis and the presence of oligoclonal bands (OCBs)...
  2. TEAR ABNORMALITIES IN NEUROLOGICAL DISEASES
    Patricia Coyle; Fiscal Year: 1990
    ..antibodies (Ab), the relative amounts of dimeric and monomeric IgA (using ELISA); and immunological markers (oligoclonal bands, Ab to myelin basic protein, distinct protein bands) using SDS polyacrylamide gel electrophoresis, ..
  3. ONTOGENY OF GENERATION OF NEONATAL ANTIBODY DIVERSITY
    Richard Insel; Fiscal Year: 2000
    ..The results of these investigations should provide novel insights into the ontogeny of the neonatal B cell repertoire and in the potential to accelerate of immunity. ..
  4. Genetic loci predisposing to multiple sclerosis (MS)
    Leena Peltonen; Fiscal Year: 2005
    ..abstract_text> ..
  5. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
    ..The program contains 3 scientific projects, an administrative core and a scientific core. Because oligoclonal bands (OGB) in multiple CNS infectious diseases are specific for the agent that causes disease, Project 1 analyzes ..
  6. Lung Transplantation and Immune Tolerance in Young Recipients
    Richard Nash; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Nonmyeloablative Hematopoietic Cell Transplantation for Severe Systemic Sclerosis
    Richard Nash; Fiscal Year: 2006
    ..The unique observations in this study regarding responses and recovery of organs after inducing a sustained remission of SSc will serve to focus and direct other non-transplant research activities. [unreadable] [unreadable] [unreadable]..
  8. Immunologic Mechanism/Destruction/Biliary Artesia
    Cara Mack; Fiscal Year: 2006
    ..Cytokine profiles will be characterized by cytokine mRNA expression. ..
  9. ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENS
    Richard Nash; Fiscal Year: 2002
    ..By lessening the morbidity and mortality associated with conventional conditioning, these studies could significantly change the management of selected inherited red blood cell diseases. ..
  10. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
  11. Cloning Kawasaki Disease-specific antigens
    Anne Rowley; Fiscal Year: 2005
    ..These plans will provide me with opportunities for enhanced career development by acquisition of new research skills, and will be fostered by the strong interdisciplinary research environment at Northwestern. ..
  12. Protection from GVHD with Gene-Modified Donor T Cells
    Richard Nash; Fiscal Year: 2008
    ....