sterigmatocystin

Summary

Summary: A carcinogenic mycotoxin produced in high yields by strains of the common molds, Aspergillus versicolor, A. nidulans, and an unidentified species of Bipolaris. It causes necrosis of the liver and kidney and has an inhibitory effect on orotic acid incorporation into nuclear RNA.

Top Publications

  1. ncbi Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity
    V Sivakumar
    Unit of Biochemistry, Department of Zoology, University of Madras, Chennai, India
    Hum Exp Toxicol 20:398-403. 2001
  2. ncbi Sterigmatocystin: occurrence in foodstuffs and analytical methods--an overview
    Aleksandrs Versilovskis
    Laboratory of membrane active substances, Latvian Institute of Organic Synthesis, Riga, Latvia
    Mol Nutr Food Res 54:136-47. 2010
  3. pmc The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development
    Naoki Kato
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Eukaryot Cell 2:1178-86. 2003
  4. pmc Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulans
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706 1187, USA
    Genetics 165:1083-93. 2003
  5. pmc Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
    D W Brown
    Department of Plant Pathology, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 93:1418-22. 1996
  6. pmc Relationship between secondary metabolism and fungal development
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Microbiol Mol Biol Rev 66:447-59, table of contents. 2002
  7. pmc veA-dependent RNA-pol II transcription elongation factor-like protein, RtfA, is associated with secondary metabolism and morphological development in Aspergillus nidulans
    Vellaisamy Ramamoorthy
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Mol Microbiol 85:795-814. 2012
  8. pmc Occurrence of toxigenic Aspergillus versicolor isolates and sterigmatocystin in carpet dust from damp indoor environments
    Steffen Engelhart
    Institute of Hygiene and Public Health, University of Bonn, Bonn, Germany
    Appl Environ Microbiol 68:3886-90. 2002
  9. pmc Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils
    Masahiro Kusunoki
    Department of Matrix Medicine, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu, Oita, 879 5593, Japan
    Environ Health Prev Med 16:224-31. 2011
  10. ncbi Sterigmatocystin production by nine newly described Aspergillus species in section Versicolores grown on two different media
    Zeljko Jurjevic
    EMSL Analytical, Inc, Cinnaminson, NJ 08077, USA
    Mycotoxin Res 29:141-5. 2013

Research Grants

  1. IMMUNOCHEMICAL STUDIES ON CARCINOGENIC MYCOTOXIN
    FUN CHU; Fiscal Year: 1990
  2. Acetate Metabolism in Mycotoxin Synthesis
    LORI MAGGIO HALL; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications171 found, 100 shown here

  1. ncbi Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity
    V Sivakumar
    Unit of Biochemistry, Department of Zoology, University of Madras, Chennai, India
    Hum Exp Toxicol 20:398-403. 2001
    b>Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1...
  2. ncbi Sterigmatocystin: occurrence in foodstuffs and analytical methods--an overview
    Aleksandrs Versilovskis
    Laboratory of membrane active substances, Latvian Institute of Organic Synthesis, Riga, Latvia
    Mol Nutr Food Res 54:136-47. 2010
    b>Sterigmatocystin (STC) is a mycotoxin produced by fungi of many different Aspergillus species. Other species such as Bipolaris, Chaetomium, Emiricella are also able to produce STC...
  3. pmc The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development
    Naoki Kato
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Eukaryot Cell 2:1178-86. 2003
    ..Specifically, veA regulates the expression of genes implicated in the synthesis of the mycotoxin sterigmatocystin and the antibiotic penicillin...
  4. pmc Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulans
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706 1187, USA
    Genetics 165:1083-93. 2003
    ..Loss of fluG results in the blockage of both conidiation and production of the mycotoxin sterigmatocystin (ST)...
  5. pmc Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
    D W Brown
    Department of Plant Pathology, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 93:1418-22. 1996
    b>Sterigmatocystin (ST) and the aflatoxins (AFs), related fungal secondary metabolites, are among the most toxic, mutagenic, and carcinogenic natural products known...
  6. pmc Relationship between secondary metabolism and fungal development
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Microbiol Mol Biol Rev 66:447-59, table of contents. 2002
    ..case of the filamentous fungus Aspergillus nidulans, we review the only described work that genetically links the sporulation of this fungus to the production of the mycotoxin sterigmatocystin through a shared G-protein signaling pathway.
  7. pmc veA-dependent RNA-pol II transcription elongation factor-like protein, RtfA, is associated with secondary metabolism and morphological development in Aspergillus nidulans
    Vellaisamy Ramamoorthy
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Mol Microbiol 85:795-814. 2012
    ..gene veA is necessary for the biosynthesis of several secondary metabolites, including the mycotoxin sterigmatocystin (ST)...
  8. pmc Occurrence of toxigenic Aspergillus versicolor isolates and sterigmatocystin in carpet dust from damp indoor environments
    Steffen Engelhart
    Institute of Hygiene and Public Health, University of Bonn, Bonn, Germany
    Appl Environ Microbiol 68:3886-90. 2002
    ..versicolor isolates in native carpet dust from damp dwellings with mold problems and to determine whether sterigmatocystin can be detected in this matrix. Carpet dust samples (n = 11) contained from <2.5 x 10(1) to 3...
  9. pmc Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils
    Masahiro Kusunoki
    Department of Matrix Medicine, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu, Oita, 879 5593, Japan
    Environ Health Prev Med 16:224-31. 2011
    The causal agents of gastric cancer could include fungus toxins. Sterigmatocystin (ST), a fungus toxin, is a risk factor of gastric cancer. We investigated the effects of ST on the stomach tissues of Mongolian gerbils.
  10. ncbi Sterigmatocystin production by nine newly described Aspergillus species in section Versicolores grown on two different media
    Zeljko Jurjevic
    EMSL Analytical, Inc, Cinnaminson, NJ 08077, USA
    Mycotoxin Res 29:141-5. 2013
    ..Aspergillus species and four known species in section Versicolores were tested for their ability to produce sterigmatocystin on two liquid media, Czapek w/20% Sucrose Broth and Yeast Extract Broth grown in the dark for 1 week at 25 °..
  11. ncbi Effects of sterigmatocystin on TNF-α, IL-6 and IL-12 expression in murine peripheral blood mononuclear cells and peritoneal macrophages in vivo
    Ying Zhang
    Department of Pathology, Second Hospital, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China
    Mol Med Rep 5:1318-22. 2012
    b>Sterigmatocystin (ST) is a toxic metabolite mainly produced by the fungi Aspergillus nidulans and Aspergillus versicolor. ST is considered a potent carcinogen, mutagen and teratogen...
  12. ncbi Determination of sterigmatocystin in cheese by high-performance liquid chromatography-tandem mass spectrometry
    A Versilovskis
    Department of Bio Analysis, Laboratory of Food Analysis, Ghent University, Ghent, Belgium
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:127-33. 2009
    Different cheese samples produced in Latvia (eight) and Belgium (13) were analysed for their sterigmatocystin (STC) content. Only two (9.5%) of the samples were positive for STC with concentration levels of 1.23 and 0...
  13. ncbi Correlation between the regulation of sterigmatocystin biosynthesis and asexual and sexual sporulation in Emericella nidulans
    D Guzmán-de-Peña
    Departamentos de Genética y Biología Molecular Unidad México, D F, Centro de Investigacion y de Estudios Avanzados del IPN, Irapuato, Gto, Mexico
    Antonie Van Leeuwenhoek 73:199-205. 1998
    We analyzed the regulation of sterigmatocystin biosynthesis in wild type and mutant strains of Emericella nidulans (= Aspergillus nidulans)...
  14. ncbi Distribution of sterigmatocystin in filamentous fungi
    Christian Rank
    Technical University of Denmark, Department of Systems Biology, Center for Microbial Biotechnology, Søltofts Plads Building 221, DK 2800 Kongens Lyngby, Denmark
    Fungal Biol 115:406-20. 2011
    During the last 50y, the carcinogenic mycotoxin sterigmatocystin (ST) has been reported in several phylogenetically and phenotypically different genera: Aschersonia, Aspergillus, Bipolaris, Botryotrichum, Chaetomium, Emericella, Eurotium, ..
  15. ncbi Contribution of uniformly 13C-enriched sterigmatocystin to the study of its pulmonary metabolism
    Odile Cabaret
    UMR BIPAR, U PEC, AFSSA, ENVA, Faculte de Medecine, Créteil Cedex F 94010, France
    Rapid Commun Mass Spectrom 25:2704-10. 2011
    ..Among these mycotoxins, sterigmatocystin is one of the most prevalent...
  16. ncbi [High levels of sterigmatocystin in patients with chronic liver diseases]
    C Hutanasu
    Facultatea de Medicina, Disciplina de Semiologie Medicală Gastroenterologie, Universitatea de Medicină si Farmacie Gr T Popa Iaşi
    Rev Med Chir Soc Med Nat Iasi 115:33-7. 2011
    b>Sterigmatocystin (STC) is a wide spread mycotoxin produced by Aspergillus fungi, with hepatotoxic and carcinogenetic proprieties.
  17. ncbi Analytical method for the determination of sterigmatocystin in grains using high-performance liquid chromatography-tandem mass spectrometry with electrospray positive ionization
    Aleksandrs Versilovskis
    National Diagnostic Centre NDC, Food and Environmental Investigations Laboratory, Lejupes iela 3, Riga LV 1076, Latvia
    J Chromatogr A 1157:467-71. 2007
    ..ESI+) MS/MS method was developed and validated for the determination of the Aspergillus mycotoxin, sterigmatocystin, in grains at levels down to less than 0.5 microg/kg...
  18. ncbi Role of hMLH1 in sterigmatocystin-induced G₂ phase arrest in human esophageal epithelial Het-1A cells in vitro
    Juan Wang
    Department of Pathology, The Second Hospital, Hebei Medical University, Shijiazhuang, China
    Toxicol Lett 217:226-34. 2013
    b>Sterigmatocystin (ST), a common environmental contaminant found across the world, is generally recognized as a potential carcinogen, mutagen and teratogen...
  19. ncbi Long-term treatment with sterigmatocystin, a fungus toxin, enhances the development of intestinal metaplasia of gastric mucosa in Helicobacter pylori-infected Mongolian gerbils
    F Ma
    Second Dept of Public Health and Hygiene, Oita Medical University, Hasama, Oita, Japan
    Scand J Gastroenterol 38:360-9. 2003
    Helicobacter pylori is a human gastric carcinogen. Sterigmatocystin (ST), a fungus toxin, is a risk factor of gastric cancer. Cytotoxin-vacuolation toxin A (VacA) present in supernatants of H...
  20. ncbi Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells
    Xin Xing
    Department of Pathology, The Second Hospital, Hebei Medical University, Shijiazhuang, P R China
    Mol Nutr Food Res 55:749-60. 2011
    b>Sterigmatocystin (ST), a mycotoxin commonly found in foodstuff and feedstuff, has been shown to be a carcinogenic mycotoxin in animal models...
  21. pmc An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin
    Kenneth C Ehrlich
    SRRC ARS USDA, 1100 R E Lee Blvd, P O Box 19687, New Orleans, LA 70179, USA
    Appl Environ Microbiol 71:8963-5. 2005
    ..This gene is predicted to encode the Baeyer-Villiger oxidase necessary for formation of the xanthone ring of the aflatoxin precursor demethylsterigmatocystin...
  22. ncbi Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro
    Xu Ming Sun
    Department of Experimental Pathology, Hebei Medical University, Shijiazhuang 050017, Hebei, China
    Biomed Environ Sci 15:145-52. 2002
    To explore the effects of Sterigmatocystin (ST), Deoxynivalenol (DON) and Aflatoxin G1 (AFG1) on apoptosis of human peripheral blood lymphocytes (HPBLs) in vitro and thus to further elucidate the putative roles of these three mycotoxins ..
  23. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
    ..Deletion of laeA (DeltalaeA) blocks the expression of metabolic gene clusters, including the sterigmatocystin (carcinogen), penicillin (antibiotic), and lovastatin (antihypercholesterolemic agent) gene clusters...
  24. ncbi VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
    ..VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites...
  25. ncbi Taxonomic comparison of three different groups of aflatoxin producers and a new efficient producer of aflatoxin B1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov
    Jens C Frisvad
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Syst Appl Microbiol 28:442-53. 2005
    ..rambellii referable to Ochraceorosei, that accumulates very large amounts of sterigmatocystin, 3-O-methylsterigmatocystin and aflatoxin B1, but not any of the other known extrolites produced by members ..
  26. ncbi Characterization of the Aspergillus ochraceoroseus aflatoxin/sterigmatocystin biosynthetic gene cluster
    J W Cary
    USDA, ARS, Southern Regional Research Center, 1100 Robert E Lee Boulevard, New Orleans, Louisiana 70124, USA
    Mycologia 101:352-62. 2009
    ..rambellii have been shown to accumulate both aflatoxin (AF) and the aflatoxin precursor sterigmatocystin (ST). Alhough morphologically distinct from A. nidulans, molecular characterization of A...
  27. ncbi Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1
    Jens C Frisvad
    Center for Microbial Biotechnology, BioCentrum DTU, Building 221, Technical University of Denmark, Lyngby, Denmark
    Syst Appl Microbiol 27:672-80. 2004
    ..Emericella venezuelensis produces aflatoxin B1, sterigmatocystin, and terrein and compounds with chromophores of the shamixanthone, emerin and desertorin type of compounds. E...
  28. pmc Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans
    N P Keller
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, Texas 77843, USA
    Appl Environ Microbiol 66:359-62. 2000
    b>Sterigmatocystin (ST) and aflatoxin B(1) (AFB(1)) are two polyketide-derived Aspergillus mycotoxins synthesized by functionally identical sets of enzymes...
  29. ncbi Emericella astellata, a new producer of aflatoxin B, B and sterigmatocystin
    J C Frisvad
    BioCentrum DTU, Technical University of Denmark, Lyngby, Denmark
    Lett Appl Microbiol 38:440-5. 2004
    ..To report on aflatoxin B(1) and B(2) production from a species of Emericella...
  30. pmc Cross-talk between light and glucose regulation controls toxin production and morphogenesis in Aspergillus nidulans
    A Atoui
    Department of Biological Sciences, Northern Illinois University, Lincoln Hwy 1425 W, DeKalb, IL 60115, USA
    Fungal Genet Biol 47:962-72. 2010
    ..In this study we show that in Aspergillus nidulans the effect of light on the production of the sterigmatocystin (ST) toxin depends on the glucose concentration...
  31. ncbi Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans
    T H Adams
    Cereon Genomics, LLC 270 Albang Sq, Cambridge, MA 02139, USA tom h
    Curr Opin Microbiol 1:674-7. 1998
    ..has provided new insights into the mechanisms coordinating production of the toxic secondary metabolite sterigmatocystin with asexual sporulation...
  32. ncbi Adsorption of sterigmatocystin by montmorillonite and inhibition of its genotoxicity in the Nile tilapia fish (Oreachromis nilaticus)
    Mosaad A Abdel-Wahhab
    Food Toxicology and Contaminants Department, National Research Center, Dokki, Cairo, Egypt
    Mutat Res 582:20-7. 2005
    b>Sterigmatocystin (Stg) is closely related to the mycotoxin aflatoxin as a precursor in aflatoxin biosynthesis and classified as an IARC Group-2B carcinogen...
  33. pmc Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin
    N P Keller
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station 77843
    Appl Environ Microbiol 60:1444-50. 1994
    Aspergillus nidulans produces the carcinogenic mycotoxin sterigmatocystin (ST), the next-to-last precursor in the aflatoxin (AF) biosynthetic pathway found in the closely related fungi Aspergillus flavus and Aspergillus parasiticus...
  34. ncbi Secondary metabolic gene cluster silencing in Aspergillus nidulans
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Drive, WI 53706, USA
    Mol Microbiol 61:1636-45. 2006
    ..e. aflR) and biosynthetic genes required for biosynthesis of sterigmatocystin (ST), a carcinogenic toxin...
  35. ncbi Dominant mutations affecting both sporulation and sterigmatocystin biosynthesis in Aspergillus nidulans
    J Wieser
    Department of Biology, Texas A and M University, College Station 77843, USA
    Curr Genet 32:218-24. 1997
    ..are not only developmentally altered but also fail to produce the toxic, carcinogenic, secondary metabolite sterigmatocystin. At least three of the mutants isolated result from dominant activating mutations in fadA which encodes the G ..
  36. ncbi A new sterigmatocystin-producing Emericella variant from agricultural desert soils
    M Klich
    SRRC, New Orleans, LA 70124, USA
    Syst Appl Microbiol 24:131-8. 2001
    An unusual, sterigmatocystin-producing taxon with characteristics of both Emericella nidulans (anamorph Aspergillus nidulans) and Emericella rugulosa (anamorph Aspergillus rugulovalvus, formerly A...
  37. ncbi Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta
    Lori A Maggio-Hall
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Plant Microbe Interact 18:783-93. 2005
    Seed contamination with polyketide mycotoxins, including aflatoxin (AF) and sterigmatocystin (ST) produced by Aspergillus spp., is an agricultural, economic, and medical issue worldwide...
  38. pmc Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase
    Ali Atoui
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Appl Environ Microbiol 74:3596-600. 2008
    ..An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels...
  39. pmc Kipukasins, nucleoside derivatives from Aspergillus versicolor
    Ping Jiao
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Nat Prod 70:1308-11. 2007
    ..The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the known metabolite sterigmatocystin, but kipukasins A and B showed modest activity in assays against Gram-positive bacteria.
  40. ncbi Characterization of aflatoxin-producing fungi outside of Aspergillus section Flavi
    J W Cary
    USDA, ARS, Southern Regional Research Center, 1100 Robert E Lee Blvd, New Orleans, Louisiana 70124, USA
    Mycologia 97:425-32. 2005
    ..Aflatoxins and sterigmatocystin production were quantified by high-pressure liquid chromatography (HPLC) and confirmed by HPLC-mass ..
  41. ncbi Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem
    Marion Brodhagen
    Department of Plant Pathology, University of Wisconsin Madison, 1630 Linden Dr, Madison, WI 53706 1598, USA
    Mol Microbiol 67:378-91. 2008
    ..nidulans, and into a DeltappoAC strain that was reduced in production of oxylipins, conidia and the mycotoxin sterigmatocystin. ZmLOX3 expression increased production of conidia and sterigmatocystin in both backgrounds...
  42. ncbi [Molecular biology of aflatoxin biosynthesis]
    Jin Xu
    Institute of Nutrition and Food Safety, China CDC, Beijing 100021, China
    Wei Sheng Yan Jiu 32:628-31. 2003
    ..This review provides several important breakthroughs on the molecular biology of aflatoxin biosynthesis and information on the regulation and evolution of the aflatoxin pathway, and the elimination of the toxin from the food chain as well...
  43. ncbi Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites
    Kevin M Henry
    Department of Chemistry, The Johns Hopkins University, Charles and 34th Streets, Baltimore, Maryland 21218, USA
    J Am Chem Soc 127:3724-33. 2005
    ..Mechanistic and stereoelectronic principles that underlie this proposal are described and may prove general as illustrated in biogenetic hypotheses for four other fungal anthraquinone --> xanthone transformations...
  44. pmc The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin
    Jeffrey W Cary
    Southern Regional Research Center ARS USDA, P O Box 19687, New Orleans, LA 70179, USA
    Appl Environ Microbiol 72:1096-101. 2006
    ..A homolog of this gene, stcQ, is present in the A. nidulans sterigmatocystin (ST) biosynthesis cluster...
  45. ncbi Spiroethers of German chamomile inhibit production of aflatoxin G and trichothecene mycotoxin by inhibiting cytochrome P450 monooxygenases involved in their biosynthesis
    Tomoya Yoshinari
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    FEMS Microbiol Lett 284:184-90. 2008
    ..1 and 103 microM, respectively. Our results suggest that the spiroethers inhibited AFG(1) and 3-ADON production by inhibiting CYPA and TRI4, respectively...
  46. ncbi Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis
    T S Hitchman
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Bioorg Chem 29:293-307. 2001
    ..The most convincing evidence of such a dedicated FAS comes from the biosyntheses of aflatoxin (AF) and sterigmatocystin (ST) in certain species of the filamentous fungus Aspergillus...
  47. ncbi The effect of Egyptian honeybee propolis on the growth of Aspergillus versicolor and sterigmatocystin biosynthesis in Ras cheese
    Salwa A Aly
    Department of Food Hygiene and Control, Faculty Veterinary Medicine, Cairo University, Egypt
    J Dairy Res 74:74-8. 2007
    ..was tested for its antifungal effect against Aspergillus versicolor ATCC 12996 as well as biosynthesis of sterigmatocystin during ripening of Egyptian Ras cheese...
  48. ncbi Aflatoxigenicity in Aspergillus: molecular genetics, phylogenetic relationships and evolutionary implications
    Jeffrey W Cary
    USDA, ARS, Southern Regional Research Center, 1100 Robert E Lee Blvd, New Orleans, LA 70124, USA
    Mycopathologia 162:167-77. 2006
    ..Characterization of the AF and sterigmatocystin (ST) gene clusters and analysis of factors governing regulation of their biosynthesis has resulted in these ..
  49. ncbi Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans
    Yong Qiang Zhang
    Department of Plant Pathology, University of Wisconsin, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Microbiol 52:541-50. 2004
    Aspergillus nidulans produces the polyketide toxin sterigmatocystin (ST) of which the biosynthetic and pathway specific regulatory genes compose a stc gene cluster...
  50. ncbi Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus
    Tomoya Yoshinari
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo 113 8657, Japan
    Microbiology 153:2774-80. 2007
    ..Furthermore, DotA inhibited production of sterigmatocystin, which is a toxic aflatoxin biosynthetic intermediate, and it also inhibited conidiation in Aspergillus ..
  51. ncbi [Experimental lung carcinoma induced by fungi and mycotoxins--a review]
    Xianghong Zhang
    Laboratory of Experimental Pathology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
    Beijing Da Xue Xue Bao 35:4-6. 2003
    ..and corn flours inoculated with Aspergillus flavus, Aspergillus versicolor in which aflatoxin G1(AFG1) and Sterigmatocystin (ST) were detected, could induce lung adenocarcinoma in Kunming, LACA and NIH mice as well as Wistar rats...
  52. ncbi Mycotoxin production by indoor molds
    Kristian Fog Nielsen
    The Mycology Group, BioCentrum DTU, Building 221, Technical University of Denmark, DK 2800, Kgs Lyngby, Denmark
    Fungal Genet Biol 39:103-17. 2003
    ..The worst-case scenario for homeowners is produced by consecutive episodes of water damage that promote fungal growth and mycotoxin synthesis, followed by drier conditions that facilitate the liberation of spores and hyphal fragments...
  53. ncbi Metal ion enhancement of fungal growth, gene expression and aflatoxin synthesis in Aspergillus flavus: RT-PCR characterization
    R Cuero
    Prairie View A and M University, CARC, PO BOX 685, Prairie View, TX 77446, USA
    J Appl Microbiol 94:953-61. 2003
    ..To determine the effect of mineral ions (e.g., Zn2+, Cu2+, and Fe2+) on the enhancement of fungal growth, total RNA, aflatoxin pathway gene expression, and production of aflatoxin and its precursor O-methylsterigmatocystin (OMST)...
  54. ncbi Generation of aflR disruption mutants of Aspergillus parasiticus
    J W Cary
    USDA, ARS, Southern Regional Research Center, New Orleans, LA 70124, USA
    Appl Microbiol Biotechnol 53:680-4. 2000
    ....
  55. ncbi RcoA has pleiotropic effects on Aspergillus nidulans cellular development
    J Hicks
    Department of Plant Pathology and Microbiology, TAMUS 2132, Texas A and M University, College Station, TX 77843-2132, USA
    Mol Microbiol 39:1482-93. 2001
    ..a recessive mutation, resulted in gross defects in vegetative growth, asexual spore production and sterigmatocystin (ST) biosynthesis...
  56. pmc Function of native OmtA in vivo and expression and distribution of this protein in colonies of Aspergillus parasiticus
    Li Wei Lee
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, USA
    Appl Environ Microbiol 68:5718-27. 2002
    ..the filamentous fungus Aspergillus parasiticus were reported to convert the aflatoxin pathway intermediate sterigmatocystin to O-methylsterigmatocystin in vitro...
  57. ncbi Identification of Aspergillus nidulans genes essential for the accumulation of sterigmatocystin
    N O Dezotti
    Department of Parasitology and Biotechnology Research Center, Institute of Biomedical Sciences, , Av. Prof. Lineu Prestes, 1374, , CEP, , 05508-900, Brazil
    Fungal Genet Biol 34:93-105. 2001
    ..nidulans) was used as a genetic model for the identification of genes required for efficient accumulation of sterigmatocystin (ST)...
  58. pmc Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver
    T Shimada
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    Proc Natl Acad Sci U S A 86:462-5. 1989
    ..closely related protein also appears to be the major catalyst involved in the activation of aflatoxin G1 and sterigmatocystin, the latter compound being more genotoxic than AFB1 in these systems...
  59. ncbi Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis
    Daniel W Udwary
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Am Chem Soc 124:5294-303. 2002
    ..Having secured the role of HOMST in aflatoxin formation, the mechanism of the second oxidative cycle of this P-450 is considered...
  60. ncbi [Specific features of albumin interactions with hemiacetals of aflatoxins and sterigmatocystin]
    G P Kononenko
    All Russian Research Institute of Veterinary Sanitation, Hygiene, and Ecology, Russian Academy of Agricultural Sciences, Moscow, 123022 Russia
    Prikl Biokhim Mikrobiol 39:116-21. 2003
    Aflatoxin B2a (AB2a), aflatoxin G2a (AG2a), and hemiacetal of sterigmatocystin have been shown to form immunoreactive conjugates with albumin...
  61. ncbi The ability of fungal isolates from human lung aspergilloma to produce mycotoxins
    S Pepeljnjak
    Department for Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR 10000 Zagreb, Croatia
    Hum Exp Toxicol 23:15-9. 2004
    ..A. versicolor strains produced AFB1 and sterigmatocystin. Neither isolated Aspergillus strain produced aflatoxin G2 or ochratoxin A...
  62. ncbi Kinetics of the oxidoreductase involved in the conversion of O-methylsterigmatocystin to aflatoxin B1
    Robert M Gengan
    Department of Chemistry, Faculty of Engineering, Science and the Built Environment, Durban University of Technology, Durban, South Africa
    Prep Biochem Biotechnol 36:297-306. 2006
    ..The Km was calculated as 5.65 microM for this CFES and varied marginally among the OMST homologues studied...
  63. ncbi Computer aided boar semen motility analysis for cereulide detection in different food matrices
    Andreja Rajkovic
    Laboratory of Food Microbiology and Food Preservation, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Belgium
    Int J Food Microbiol 114:92-9. 2007
    ..cereus Hemolysin BL (HBL) and non-hemolytic enterotoxin (NHE) and three mycotoxins (Sterigmatocystin, Fumonisin B1 and Patulin) exhibited a toxic impact on semen progressive motility...
  64. pmc DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin
    Kirsten E Rakkestad
    Department of Air Pollution and Noise, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Toxicol Sci 115:140-55. 2010
    ..chartarum isolate IBT 9634, and sterigmatocystin-producing Aspergillus versicolor isolate IBT 3781, as well as the trichothecenes T-2 and satratoxin G...
  65. ncbi Molds and mycotoxins in dust from water-damaged homes in New Orleans after hurricane Katrina
    E Bloom
    Laboratory Medicine, Division of Medical Microbiology, Lund University, Solvegatan 23, Lund, Sweden
    Indoor Air 19:153-8. 2009
    ..was identified in three dust samples by gas chromatography-tandem mass spectrometry, and sterigmatocystin (produced by various Aspergillus spp...
  66. ncbi Species-specific profiles of mycotoxins produced in cultures and associated with conidia of airborne fungi derived from biowaste
    G Fischer
    Institute of Hygiene and Environmental Medicine, University Hospital, RWTH Aachen, Germany
    Int J Hyg Environ Health 203:105-16. 2000
    ..Some mycotoxins, such as sterigmatocystin in Emericella nidulans, were not present in the conidial extracts, though produced by most strains...
  67. ncbi Development of a liquid chromatography/tandem mass spectrometry method for the simultaneous determination of 16 mycotoxins on cellulose filters and in fungal cultures
    B Delmulle
    Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Food Analysis, Harelbekestraat 72, 9000 Ghent, Belgium
    Rapid Commun Mass Spectrom 20:771-6. 2006
    ..nivalenol, deoxynivalenol, zearalenone, diacetoxyscirpenol, T-2 toxin, verrucarol, verrucarin A, neosolaniol, sterigmatocystin, roridin A, ochratoxin A, aflatoxin B1, aflatoxin B2, aflatoxin G1 and aflatoxin G2, which can be produced by ..
  68. ncbi Analysis of multiple mycotoxins in beer employing (ultra)-high-resolution mass spectrometry
    Milena Zachariasova
    Institute of Chemical Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Chemistry and Analysis, Technicka 3, 166 28 Prague 6, Czech Republic
    Rapid Commun Mass Spectrom 24:3357-67. 2010
    ..the control of 32 mycotoxins (Fusarium and Alternaria toxins, aflatoxins, ergot alkaloids, ochratoxins, and sterigmatocystin) in beer...
  69. pmc Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
    K Shimizu
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843 2132, USA
    Genetics 157:591-600. 2001
    ..domain protein, encoded by fadA and flbA, respectively, regulate production of the carcinogenic metabolite sterigmatocystin (ST) and asexual spores (i.e., conidia)...
  70. pmc The carboxy-terminal portion of the aflatoxin pathway regulatory protein AFLR of Aspergillus parasiticus activates GAL1::lacZ gene expression in Saccharomyces cerevisiae
    P K Chang
    Southern Regional Research Center, Agricultural Research Service, U S Department of Agriculture, New Orleans, Louisiana 70124, USA
    Appl Environ Microbiol 65:2508-12. 1999
    ..expression of aflatoxin biosynthesis genes in Aspergillus parasiticus and Aspergillus flavus, as well as the sterigmatocystin synthesis genes in Aspergillus nidulans...
  71. pmc Mycotoxins in crude building materials from water-damaged buildings
    T Tuomi
    Finnish Institute of Occupational Health FIOH, Uusimaa Regional Institute, FIN 00370 Helsinki, Finland
    Appl Environ Microbiol 66:1899-904. 2000
    ..We found the aflatoxin precursor, sterigmatocystin, in 24% of the samples and trichothecenes in 19% of the samples...
  72. ncbi Aspergillus nidulans VeA subcellular localization is dependent on the importin alpha carrier and on light
    Suzanne M Stinnett
    Northern Illinois University, Biological Sciences, 1425 W Lincoln Hwy Montgomery Hall, DeKalb, IL 60115, USA
    Mol Microbiol 63:242-55. 2007
    ..We also evaluated the effect of light on production of the mycotoxin sterigmatocystin in a veA wild-type and the veA1 mutant strains and found that the highest amount of toxin was produced by the ..
  73. ncbi JEM Spotlight: Fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings
    Viviana Polizzi
    Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Food Analysis, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Environ Monit 11:1849-58. 2009
    ..The mycotoxins found were mainly roquefortine C, chaetoglobosin A and sterigmatocystin but also roridin E, ochratoxin A, aflatoxin B(1) and aflatoxin B(2) were detected...
  74. pmc Gene duplication, modularity and adaptation in the evolution of the aflatoxin gene cluster
    Ignazio Carbone
    Center for Integrated Fungal Research, Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695 USA
    BMC Evol Biol 7:111. 2007
    ..enzymatic reactions in a complex polyketide pathway that converts acetate and malonate to the intermediates sterigmatocystin (ST) and O-methylsterigmatocystin (OMST), the respective penultimate and ultimate precursors of AF...
  75. ncbi Fungi on wheat bran and their toxinogenity
    Dana Tancinova
    Department of Microbiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Tr A Hlinku 2, 949 76 Nitra, Slovak Republic
    Ann Agric Environ Med 16:325-31. 2009
    ..griseofulvin (23 isolates), ochratoxin A (14 isolates), patulin (30 isolates), penitrem A (18 isolates) and sterigmatocystin (7 isolates). Furthermore, fumonisin B1 as well as moniliformin producing Fusarium strains, were recovered...
  76. ncbi Metabolic detoxication pathways for sterigmatocystin in primary tracheal epithelial cells
    Odile Cabaret
    UMR BIPAR, U PEC, AFSSA, ENVA, Faculté de Médecine, Créteil, France
    Chem Res Toxicol 23:1673-81. 2010
    ..Among these mycotoxins, sterigmatocystin is one of the most prevalent...
  77. ncbi Four new species of Emericella from the Mediterranean region of Europe
    Polona Zalar
    University of Ljubljana, Biotechnical Faculty, Biology Department, Vecna pot 111, 1000 Ljubljana, Slovenia
    Mycologia 100:779-95. 2008
    ..filifera produced shamixanthone and varitriols; E. discophora produced sterigmatocystin and versicolorins; E...
  78. ncbi Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations
    Urban Bren
    National Institute of Chemistry, Hajdrihova 19, SI 1001 Ljubljana, Slovenia
    Chem Res Toxicol 20:1134-40. 2007
    ..This explains why the planar region of related mycotoxins sterigmatocystin and aflatoxin G 1 could have been evolutionarily optimized in a different way.
  79. ncbi [Detection of sterigmatocystin based on the novel aflatoxin-oxidase/chitosan-single-walled carbon nanotubes/poly-o-phenylenediamine modified electrode]
    Junhua Chen
    Institute of Microbial Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
    Sheng Wu Gong Cheng Xue Bao 25:2029-35. 2009
    A sensitive electrochemical biosensor based on Aflatoxin-Oxidase (AFO) was developed for detection of sterigmatocystin (ST)...
  80. pmc Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes
    Rosie E Bradshaw
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Appl Environ Microbiol 68:2885-92. 2002
    ..pini clone was identified that contained four dot genes with similarity to genes in aflatoxin and sterigmatocystin gene clusters with predicted activities of a ketoreductase (dotA), oxidase (dotB), major facilitator ..
  81. pmc A key role for vesicles in fungal secondary metabolism
    Anindya Chanda
    Department of Food Science and Human Nutrition, National Food Safety and Toxicology Center, and Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824
    Proc Natl Acad Sci U S A 106:19533-8. 2009
    ..parasiticus under aflatoxin-inducing conditions converts sterigmatocystin, a late intermediate in aflatoxin synthesis, to aflatoxin B(1); these organelles also compartmentalize ..
  82. ncbi Cloning and characterization of avfA and omtB genes involved in aflatoxin biosynthesis in three Aspergillus species
    J Yu
    Southern Regional Research Center, USDA, Agricultural Research Service, New Orleans, LA 70179, USA
    Gene 248:157-67. 2000
    ..omtB, encoding for an O-methyltransferase involved in the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST), was cloned from A...
  83. pmc FluG-dependent asexual development in Aspergillus nidulans occurs via derepression
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 172:1535-44. 2006
    ..be necessary for activation of asexual sporulation (conidiation) and production of the carcinogenic mycotoxin sterigmatocystin (ST) in the model filamentous fungus Aspergillus nidulans, the molecular mechanisms underlying the ..
  84. pmc FvVE1 regulates biosynthesis of the mycotoxins fumonisins and fusarins in Fusarium verticillioides
    Kyung Myung
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    J Agric Food Chem 57:5089-94. 2009
    The veA gene positively regulates sterigmatocystin production in Aspergillus nidulans and aflatoxin production in Aspergillus parasiticus and Aspergillus flavus ...
  85. ncbi Analysis of multiple mycotoxins in cereals under ambient conditions using direct analysis in real time (DART) ionization coupled to high resolution mass spectrometry
    Lukas Vaclavik
    Institute of Chemical Technology Prague, Department of Food Chemistry and Analysis, Technicka 5, 16628 Prague 6, Czech Republic
    Talanta 82:1950-7. 2010
    ..deepoxy-deoxynivalenol, fusarenon-X, altenuene, alternariol, alternariolmethylether, diacetoxyscirpenol, sterigmatocystin). The lowest calibration levels (LCLs) estimated for the respective analytes ranged from 50 to 150 μg kg(-1)...
  86. ncbi Metabolic activation of four drugs in the eye mosaic assay measuring principally mitotic recombination in Drosophila melanogaster: differences in strain susceptibility and route of exposure
    R Rodriguez-Arnaiz
    Laboratorio de Genetica, Facultad de Ciencias, Coyoacan, Mexico, D F, Mexico
    Mutat Res 305:157-63. 1994
    ..of light spots almost one order of magnitude higher than those obtained with the carcinogen mycotoxin sterigmatocystin (STC), the antiprotozoal and antimicrobial metronidazole (MNZ), and the antifungal griseofulvin (GF)...
  87. pmc Asexual sporulation in Aspergillus nidulans
    T H Adams
    Department of Biology, Texas A and M University, College Station 77843, USA
    Microbiol Mol Biol Rev 62:35-54. 1998
    ..and represses both asexual and sexual sporulation as well as production of the toxic secondary metabolite, sterigmatocystin. The second pathway apparently requires an extracellular signal to induce sporulation-specific events and to ..
  88. ncbi Direct detection using the Drosophila DNA-repair test and isolation of a DNA-damaging mycotoxin, 5,6-dihydropenicillic acid, in fungal culture
    H Obana
    Osaka Prefectural Institute of Public Health, Japan
    Food Chem Toxicol 32:37-43. 1994
    ..The extracts of A. parasiticus and A. versicolor contained aflatoxin B1 and sterigmatocystin, respectively. The DNA-damaging compound in the extract of A...
  89. ncbi Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy
    Maria Karlgren
    Karolinska Institutet, Section of Pharmacogenetics, Department of Physiology and Pharmacology, SE 171 77 Stockholm, Sweden
    Expert Opin Ther Targets 11:61-7. 2007
    ..activate several procarcinogens, including polycyclic aromatic hydrocarbon dihydrodiols, aflatoxin B1 and sterigmatocystin. The gene expression is governed by gene methylation...
  90. ncbi Biosynthesis of dothistromin
    Rosie E Bradshaw
    National Centre for Advanced Bio Protection Technologies, Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Mycopathologia 162:201-13. 2006
    ..is a mycotoxin that is remarkably similar in structure to versicolorin B, a precursor of both aflatoxin and sterigmatocystin. Dothistromin-producing fungi also produce related compounds, including some aflatoxin precursors as well as ..
  91. ncbi Detection of aflatoxins (G(1-2), B(1-2)), sterigmatocystin, citrinine and ochratoxin A in samples contaminated by microbes
    T Tuomi
    Finnish Institute of Occupational Health, Uusimaa Regional Institute, Helsinki
    Analyst 126:1545-50. 2001
    ..is described for the simultaneous determination of common aflatoxins (G1, G2, B1, B2) and their precursor sterigmatocystin, and also citrinine and ochratoxin A...
  92. ncbi Cloning and functional expression of an esterase gene in Aspergillus parasitcus
    Jiujiang Yu
    Southern Regional Research Center, USDA, Agricultural Research Service, New Orleans, Louisiana 70124, USA
    Mycopathologia 156:227-34. 2002
    ..The estA gene is a homolog of the stcI gene identified in A. nidulans involved in the biosynthesis of sterigmatocystin and dihydro-sterigmatocystin for the conversion of versiconal hemiacetal acetate to versiconal...
  93. ncbi Molecular characterization of StcI esterase from Aspergillus nidulans
    Carolina Peña-Montes
    Food and Biotechnology Department, Chemistry Faculty, National Autonomous University of Mexico, Ciudad Universitaria, Mexico City, DF 04510, Mexico
    Appl Microbiol Biotechnol 84:917-26. 2009
    Aspergillus nidulans produces StcI esterase, which is involved in the biosynthesis of sterigmatocystin, a precursor of aflatoxins. Previous reports of this esterase in A...
  94. ncbi A novel biosensor for sterigmatocystin constructed by multi-walled carbon nanotubes (MWNT) modified with aflatoxin-detoxifizyme (ADTZ)
    Dong Sheng Yao
    Lab of Biotechnology, Life Science and Technology College, Jinan University, China
    Bioelectrochemistry 68:126-33. 2006
    b>Sterigmatocystin, ST, is carcinogenic mycotoxin with toxicity second to aflatoxins, contaminated in foods- and feeds-stuff widely...
  95. pmc Aspergillus has distinct fatty acid synthases for primary and secondary metabolism
    D W Brown
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 93:14873-7. 1996
    ..mutants require long-chain fatty acids for growth, whereas sFAS mutants grow normally but cannot synthesize sterigmatocystin (ST), a carcinogenic secondary metabolite structurally and biosynthetically related to aflatoxin...
  96. ncbi [Establishment of transgenic cell line CHL-3A4 and its metabolic activation]
    Q Chen
    Institute for Hematology, First Hospital Affiliated to Zhejiang Medical University, Hangzhou
    Zhonghua Yu Fang Yi Xue Za Zhi 32:281-4. 1998
    ..To establish a model cell line CHL-3A4 to study metabolic pathways for some genotoxic chemicals...
  97. ncbi [The mechanisms of gastric cancer development produced by the combination of Helicobacter pylori with Sterigmatocystin, a mycotoxin]
    Junichi Misumi
    Department of Human Environmental and Social Medicine, Division of Preventive Medicine, Oita University Faculty of Medicine
    Nihon Rinsho 62:1377-86. 2004
    ..b>Sterigmatocystin is a mycotoxin and a precursor of aflatoxin which is produced by Aspergillus versicolor...
  98. ncbi Regulation of secondary metabolism in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Phytopathol 43:437-58. 2005
    ..Particularly, the roles of G protein signaling components and developmental regulators in the mycotoxin sterigmatocystin biosynthesis in the model fungus Aspergillus nidulans are discussed in depth.
  99. ncbi Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, WI 53706, USA
    J Microbiol 44:145-54. 2006
    ..In particular, their functions in controlling hyphal proliferation, asexual spore formation, sexual fruiting, and the mycotoxin sterigmatocystin production are discussed.
  100. ncbi LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs
    Martien C Spanjer
    National Reference Laboratory for Mycotoxins and Pesticides in Food, Food and Consumer Product Safety Authority VWA, Hoogte Kadijk 401, The Netherlands
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:472-89. 2008
    ..A, deoxynivalenol, zearalenone, T-2 toxin, HT-2 toxin, alpha-zearalenol, alpha-zearalanol, beta-zearalanol, sterigmatocystin, cyclopiazonic acid, penicillic acid, fumonisins B1, B2 and B3, diacetoxyscirpenol, 3- and 15-acetyl-..
  101. pmc Seven new and two known lipopeptides as well as five known polyketides: the activated production of silent metabolites in a marine-derived fungus by chemical mutagenesis strategy using diethyl sulphate
    Chang jing Wu
    Key Laboratory of Structure Based Drug Design and Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
    Mar Drugs 12:1815-38. 2014
    ..B (8), fellutamide C (9), 1'-O-methylaverantin (10), averantin (11), averufin (12), nidurufin (13), and sterigmatocystin (14). In the MTT assay, 1-14 inhibited several human cancer cell lines to varying extents...

Research Grants3

  1. IMMUNOCHEMICAL STUDIES ON CARCINOGENIC MYCOTOXIN
    FUN CHU; Fiscal Year: 1990
    ..Specific antibodies against different mycotoxins including aflatoxins B1, B1-diol, G1, M1, Q, ochratoxin A, sterigmatocystin, and trichothecene mycotoxins such as T-2 toxin, diacetoxyscirpenol, deoxynivalenol and deoxyverrucarol have ..
  2. Acetate Metabolism in Mycotoxin Synthesis
    LORI MAGGIO HALL; Fiscal Year: 2004
    b>Sterigmatocystin (SI) is a carcinogenic polyketide mycotoxin produced by members of the Aspergillus genus...