peptidyl dipeptidase a

Summary

Summary: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.

Top Publications

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
  2. ncbi Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    Chad Vickers
    Department of Metabolic Disease, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:14838-43. 2002
  3. ncbi A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
    S R Tipnis
    Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds, United Kingdom
    J Biol Chem 275:33238-43. 2000
  4. pmc Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
    Gillian I Rice
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 383:45-51. 2004
  5. ncbi Angiotensin-converting enzyme 2 is an essential regulator of heart function
    Michael A Crackower
    Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nature 417:822-8. 2002
  6. ncbi Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
    Ramanathan Natesh
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nature 421:551-4. 2003
  7. ncbi Angiotensin-converting enzyme 2 protects from severe acute lung failure
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A 1030, Austria
    Nature 436:112-6. 2005
  8. pmc Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure
    X Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Hum Genet 68:1139-48. 2001
  9. pmc Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
    F Soubrier
    Institut National de la Sante et de la Recherche Medicale, Unite 36, Paris, France
    Proc Natl Acad Sci U S A 85:9386-90. 1988
  10. pmc The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice
    C R Esther
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 99:2375-85. 1997

Research Grants

Detail Information

Publications258 found, 100 shown here

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ..The full text of this article is available at http://www. circresaha.org...
  2. ncbi Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    Chad Vickers
    Department of Metabolic Disease, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:14838-43. 2002
    ..An alignment of the ACE2 peptide substrates reveals a consensus sequence of: Pro-X((1-3 residues))-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid...
  3. ncbi A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
    S R Tipnis
    Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds, United Kingdom
    J Biol Chem 275:33238-43. 2000
    ..4 kilobase pairs and is most highly expressed in testis, kidney, and heart. This is the first report of a mammalian homolog of ACE and has implications for our understanding of cardiovascular and renal function...
  4. pmc Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
    Gillian I Rice
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 383:45-51. 2004
    ..These kinetic data highlight that the flux of peptides through the RAS is complex, with the levels of ACE, ACE2 and NEP dictating whether vasoconstriction or vasodilation will predominate...
  5. ncbi Angiotensin-converting enzyme 2 is an essential regulator of heart function
    Michael A Crackower
    Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nature 417:822-8. 2002
    ..But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo...
  6. ncbi Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
    Ramanathan Natesh
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nature 421:551-4. 2003
    ..The structure provides an opportunity to design domain-selective ACE inhibitors that may exhibit new pharmacological profiles...
  7. ncbi Angiotensin-converting enzyme 2 protects from severe acute lung failure
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A 1030, Austria
    Nature 436:112-6. 2005
    ..Our data identify a critical function for ACE2 in acute lung injury, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year...
  8. pmc Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure
    X Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Hum Genet 68:1139-48. 2001
    ..Furthermore, allelic interaction may play an important role in the dissection of complex traits such as BP...
  9. pmc Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
    F Soubrier
    Institut National de la Sante et de la Recherche Medicale, Unite 36, Paris, France
    Proc Natl Acad Sci U S A 85:9386-90. 1988
    ..Whereas the ACE gene is transcribed as a 4.3-kilobase mRNA in vascular endothelial cells, a 3.0-kilobase transcript was detected in the testis, where a shorter form of ACE is synthesized...
  10. pmc The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice
    C R Esther
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 99:2375-85. 1997
    ..These studies strongly support the concept that the tissue-bound ACE is essential to the control of blood pressure and the structure and function of the kidney...
  11. ncbi Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence
    Jodie L Guy
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Biochemistry 42:13185-92. 2003
    ....
  12. ncbi Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease
    C Kramers
    Department of Pharmacology/Toxicology, Laboratory of Tumor Immunology, University Medical Center, Nijmegen, The Netherlands
    Circulation 104:1236-40. 2001
    ..These findings qualify the importance of serum ACE and establish a new determinant of ACE solubilization...
  13. pmc The renin-angiotensin system and diabetes: an update
    Antônio Ribeiro-Oliveira
    Laboratorio de Endocrinologia, Departamento de Clinica Medica, Centro Universitário de Belo Horizonte, UNIBH, Belo Horizonte, MG, Brazil
    Vasc Health Risk Manag 4:787-803. 2008
    ....
  14. ncbi The presence of allele D of angiotensin-converting enzyme polymorphism is associated with diabetic nephropathy in patients with less than 10 years duration of Type 2 diabetes
    L H Canani
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabet Med 22:1167-72. 2005
    ..To investigate the association between angiotensin-converting enzyme gene I/D polymorphism and diabetic nephropathy (DN) in patients with Type 2 diabetes mellitus (DM) taking into consideration the known duration of DM...
  15. ncbi The angiotensinogen gene 235T variant is associated with an increased risk of restenosis after percutaneous transluminal coronary angioplasty
    H Volzke
    Clinic of Internal Medicine B, Ernst Moritz Arndt University, Greifswald, Germany
    Clin Sci (Lond) 99:19-25. 2000
    ..We conclude that the angiotensinogen M235T gene polymorphism may be an independent predictor of restenosis after PTCA...
  16. ncbi Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?
    Mark C Chappell
    Hypertension and Vascular Disease Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27015, USA
    Hypertension 50:596-9. 2007
  17. ncbi High-resolution genetic mapping of the ACE-linked QTL influencing circulating ACE activity
    Florent Soubrier
    INSERM U 525, Faculté de Médecine Pitié Salpêtrière, Universite Paris VI, 91 Bd de l Hopital, 75013 Paris, France
    Eur J Hum Genet 10:553-61. 2002
    ..The approaches developed will be applicable to the fine-mapping of other quantitative trait loci in humans...
  18. ncbi Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocr Rev 24:261-71. 2003
    ..The role of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light of these newly recognized components...
  19. ncbi Sequence variation in the human angiotensin converting enzyme
    M J Rieder
    University of Washington, Department of Molecular Biotechnology, Seattle 98195, USA
    Nat Genet 22:59-62. 1999
    ..The highly correlated structure in DCP1 raises important issues for the determination of functional DNA variants within genes and genetic studies in humans based on marker association...
  20. ncbi Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells
    Z Su
    Division of Nephrology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
    Kidney Int 69:2212-8. 2006
    ..Generation of Ang-(1-7) by proximal tubular ACE2 could thereby serve a protective role by counteracting the effects of locally generated Ang II...
  21. ncbi SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells
    I Chueh Huang
    Pulmonary Division, Children s Hospital, Children s Hospital Laboratory of Molecular Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:3198-203. 2006
    ..Our data indicate that two coronaviruses that utilize a common receptor nonetheless enter cells through distinct mechanisms...
  22. ncbi Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
    Jose A Hernandez Prada
    McKnight Brain Institute and Department of Physiology, College of Medicine, University of Florida, Gainesville, USA
    Hypertension 51:1312-7. 2008
    ..We conclude that structure-based screening can help identify compounds that activate ACE2, decrease blood pressure, and reverse tissue remodeling. Administration of ACE2 activators may be a valid strategy for antihypertensive therapy...
  23. ncbi ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
    Paul Towler
    Drug Discovery and Protein Sciences, Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    J Biol Chem 279:17996-8007. 2004
    ....
  24. ncbi Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor
    Rebecca A Lew
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Clayton, Victoria 3800, Australia
    Exp Physiol 93:685-93. 2008
    ..e.m., 4.44 +/- 0.56 pmol min-1 ml-1). Future studies of patients with cardiovascular, renal and liver disease will determine whether plasma ACE2 is elevated in parallel with increased tissue levels observed in these conditions...
  25. ncbi Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
    Heather N Reich
    Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 74:1610-6. 2008
    ..Our results suggest that the kidney disease of patients with type 2 diabetes is associated with a reduction in ACE2 gene and protein expression and this may contribute to the progression of renal injury...
  26. ncbi ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites
    B Agerholm-Larsen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 20:484-92. 2000
    ....
  27. ncbi Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design
    Hazel R Corradi
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 357:964-74. 2006
    ..The structure now provides a platform for the design of "domain-specific" second-generation ACE inhibitors...
  28. ncbi ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice
    M J Soler
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Kidney Int 72:614-23. 2007
    ..Our study shows that chronic pharmacologic ACE2 inhibition worsens glomerular injury in streptozotocin-induced diabetic mice in association with increased ACE expression...
  29. ncbi Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study
    C J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Mass 01701, USA
    Circulation 97:1766-72. 1998
    ..We investigated these relations in a large population-based sample of men and women by using association and linkage analyses...
  30. ncbi Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart
    Chantal Mercure
    Clinical Research Institute of Montreal IRCM, Montreal, Canada
    Circ Res 103:1319-26. 2008
    ....
  31. ncbi Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    Wenhui Li
    Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
    Nature 426:450-4. 2003
    ..Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV...
  32. pmc Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
    Anura P Jayasooriya
    Dean s Ganglion, Centre for Neuroscience, Department of Physiology, and Royal Melbourne Hospital, Faculty of Medicine, and Howard Florey Institute, University of Melbourne, Victoria 3010, Australia
    Proc Natl Acad Sci U S A 105:6531-6. 2008
    ....
  33. ncbi Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
    Maria Paz Ocaranza
    Departamento Enfermedades Cardiovasculares, Escuela de Medicina, P Universidad Catolica de Chile
    Hypertension 48:572-8. 2006
    ..These findings suggest that in this second arm of the renin-angiotensin system, ACE2 may act through Ang-(1-9), rather than Ang-(1-7), as a counterregulator of the first arm, where ACE catalyzes the formation of Ang II...
  34. ncbi Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study
    S Hadjadj
    Medecine B, Centre Hospitalier Universitaire, Angers, Paris, France
    J Am Soc Nephrol 12:541-9. 2001
    ..The AGT M235T polymorphism was not associated with renal events. The D allele of the ACE I/D polymorphism is an independent risk factor for both the onset and the progression of diabetic nephropathy in type 1 diabetes mellitus patients...
  35. ncbi Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region
    M Eyries
    Institut National de la Santé et de la Recherche Médicale Unit 525, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75013 Paris, France
    J Biol Chem 276:5525-32. 2001
    ..Our results show that different molecular mechanisms are responsible for the common genetic variation of plasma ACE and for its more rare familial elevation...
  36. ncbi Two quantitative trait loci affect ACE activities in Mexican-Americans
    Candace M Kammerer
    Graduate School of Public Health, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hypertension 43:466-70. 2004
    ..We also have evidence that an additional QTL affects ACE activity. Identification of this additional QTL might lead to alternate means of prophylaxis...
  37. ncbi Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    T Lau
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetologia 47:240-8. 2004
    ..This study aimed, primarily, to investigate the existence of a local angiotensin-generating system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin secretion...
  38. ncbi Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors
    Dimitris Georgiadis
    Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens, Greece
    Circ Res 93:148-54. 2003
    ..Based on these findings, it might be suggested that the gene duplication of ACE in vertebrates may represent a means for regulating the cleavage of Ang I differently from that of BK...
  39. ncbi Frequency of angiotensin-converting enzyme gene polymorphism in Turkish type 2 diabetic patients
    I Degirmenci
    Department of Medical Biology, Medical Faculty, Osmangazi University, Eskisehir, Turkey
    Int J Clin Pract 59:1137-42. 2005
    ..ID genotype was suggested to be a risk factor and II was suggested to be protective for diabetic neuropathy. The DD and ID genotypes might be a predictor for the development of retinopathy in relation to duration of diabetes...
  40. ncbi A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
    Keiji Kuba
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Med 11:875-9. 2005
    ..These results provide a molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses...
  41. ncbi Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease
    R Alvarez
    Laboratorio de Genética Molecular Instituto de Investigación Nefrológica, Hospital Central de Asturias, Oviedo, Spain
    Nitric Oxide 5:343-8. 2001
    ..82; 95% CI = 1.40, 5.70). Although based on a limited number of patients, our work suggests that individuals who are NOS3-CC + ACE-DD are at a higher risk for early CAD, probably as a consequence of increased endothelial dysfunction...
  42. ncbi Blockade of angiotensin AT1a receptor signaling reduces tumor growth, angiogenesis, and metastasis
    Mamoru Fujita
    Department of Pharmacology, Kitasato University School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 294:441-7. 2002
    ..Blockade of AT1a-R signaling may therefore become an effective novel strategy for tumor chemoprevention...
  43. ncbi Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population
    Trinidad Mata-Balaguer
    Departamento de Genetica, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain
    Int J Cardiol 95:145-51. 2004
    ..To evaluate the genetic contribution to myocardial infarction in a homogeneous Caucasian population (a Mediterranean Spanish population) with very low frequency of coronary heart disease (CHD)...
  44. ncbi Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women
    Giorgio Mello
    Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Viale GB Morgagni 85, 50134 Florence, Italy
    Hypertension 45:86-91. 2005
    ..LMWH reduces the recurrence of preeclampsia, of negative outcomes, and the resistance of uteroplacental flow, and also prevents maternal blood pressure increase in ACE DD homozygote women with a previous history of preeclampsia...
  45. ncbi Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arch Intern Med 168:1077-89. 2008
    ..To shed light on these inconclusive findings, we conducted a meta-analysis of studies relating the ACE I/D polymorphic variant to the risk of CAD...
  46. ncbi Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site
    V Beldent
    Institut National de la Sante et de la Recherche Medicale, Unit 36, College de France, Paris
    J Biol Chem 268:26428-34. 1993
    ..In addition, the carboxyl-terminal sequence of the human plasma ACE was identified as AGQR, thus supporting the fact that a similar mechanism could operate in human vascular cells...
  47. ncbi Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness: a meta-analysis
    Fakhredin A Sayed-Tabatabaei
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:1634-9. 2003
    ..The aim of this study was to evaluate this association by performing a meta-analysis on published articles...
  48. ncbi Ace revisited: a new target for structure-based drug design
    K Ravi Acharya
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nat Rev Drug Discov 2:891-902. 2003
  49. ncbi End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms
    Peter D Arkwright
    Academic Unit of Child Health, Booth Hall Children s Hospital, and School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 167:384-9. 2003
    ....
  50. ncbi Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis
    V J Dzau
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hypertension 37:1047-52. 2001
    ..This model may also explain the beneficial effects of ACE inhibitors on cardiovascular events beyond blood pressure reduction...
  51. ncbi Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
    H J Jacob
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 67:213-24. 1991
    ..We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals...
  52. pmc Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer
    Yoriko Yamazato
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, PO Box 100274, Gainesville, FL 32610 0274, USA
    Hypertension 54:365-71. 2009
    ....
  53. ncbi Increased D allele frequency of the angiotensin-converting enzyme gene in pulmonary fibrosis
    C D Morrison
    Department of Anatomic Pathology and Molecular Pathology, Ohio State University, Columbus, OH 43210, USA
    Hum Pathol 32:521-8. 2001
    ..1; chi(2) test); there were marginally significantly more D alleles among the 48 observed alleles than would be expected (P =.04)...
  54. ncbi Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2
    Lawrence S Zisman
    The Heart Institute and The Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Circulation 108:1707-12. 2003
    ..The formation of angiotensin-(1-7) from either angiotensin (Ang) I or Ang II in failing human hearts is not well understood...
  55. ncbi Properties and distribution of angiotensin I converting enzyme
    Rajko Igic
    Department of Anesthesiology and Pain Management, Cook County Hospital, Chicago, IL 60612, USA
    Curr Pharm Des 9:697-706. 2003
    ..A safer way of producing therapeutic effects is promised by the delivery of the ACE antisense sequences by a vector producing a permanent inhibition of ACE and long-term control of blood pressure in hypertensive patients...
  56. ncbi Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease
    S F Wu
    Department of Pediatrics, China Medical University Hospital, No 2 Yuh Der Road Taichung, Taiwan, Republic of China
    Pediatr Cardiol 25:529-33. 2004
    ....
  57. pmc Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity
    T A Williams
    INSERM U36, College de France, Paris, France
    Biochem J 318:125-31. 1996
    ....
  58. pmc Angiotensin-converting enzyme and male fertility
    J R Hagaman
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:2552-7. 1998
    ..Males heterozygous for the mutation inactivating both ACE isozymes sire wild-type and heterozygous offspring at an indistinguishable frequency, indicating no selection against sperm carrying the mutation...
  59. ncbi The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors
    L Wei
    Institut de la Santé et de la Recherche Médicale Unité 36, Paris, France
    J Biol Chem 267:13398-405. 1992
    ..The different inhibitor binding properties of the two domains observed in the present study provide strong evidence for the presence of structural differences between the two active sites of ACE...
  60. ncbi A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus
    Daniel P K Ng
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    Diabetes 55:2660-3. 2006
    ..T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus...
  61. pmc Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis
    Gavin Y Oudit
    Rm 68, 150 College St, Heart and Stroke Richard Lewar Centre of Excellence, Fitzgerald Bldg, University of Toronto, Toronto M5S 3E2, Canada
    Am J Pathol 168:1808-20. 2006
    ..These findings have important implications for our understanding of ACE2, the renin-angiotensin system, and gender in renal injury, with ACE2 likely to be an important therapeutic target in kidney disease...
  62. ncbi Haplotypes extending across ACE are associated with Alzheimer's disease
    Patrick G Kehoe
    Department of Care of the Elderly, University of Bristol, The John James Building, Frenchay Hospital, Bristol, UK
    Hum Mol Genet 12:859-67. 2003
    ..Results support a model whereby decreased ACE activity may influence AD susceptibility by a mechanism involving beta-amyloid metabolism...
  63. ncbi ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes
    Chris Tikellis
    Danielle Alberti Memorial Centre for Diabetes Complications, Baker Medical Research Institute, Melbourne, Australia
    Diabetes 57:1018-25. 2008
    ..This study examines the role of ACE2 in early renal changes associated with diabetes and the influence of ACE2 deficiency on ACE inhibitor-mediated renoprotection...
  64. pmc Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2
    G Paizis
    University of Melbourne, Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
    Gut 54:1790-6. 2005
    ..The renin-angiotensin system (RAS) has been implicated in the pathogenesis of cirrhosis but the role of ACE2 in liver disease is not known...
  65. ncbi Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis
    M Linnebank
    Klinik und Poliklinik fuer Neurologie, Universitaetsklinikum Bonn, Germany
    Neurology 61:1819-20. 2003
  66. ncbi An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site
    Darren R Brooks
    Molecular and Cellular Biosciences Research, Faculty of Biological Sciences, Miall Building, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 278:52340-6. 2003
    ....
  67. ncbi Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells
    Karin Kohlstedt
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 94:60-7. 2004
    ..Thus, ACE is involved in outside-in signaling in endothelial cells and "ACE signaling" may be an important cellular mechanism contributing to the beneficial effects of ACE inhibitors...
  68. ncbi Human performance: a role for the ACE genotype?
    Alun Jones
    Department of Cardiovascular Genetics, Rayne Institute, University College London, UK
    Exerc Sport Sci Rev 30:184-90. 2002
    ..Conversely, the D allele is associated with training-related strength gain and elite power-oriented performance secondary to increased ACE and angiotensin II, a growth factor...
  69. pmc Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites
    Z L Woodman
    Department of Medical Biochemistry, University of Cape Town, Rondebosch 7700, South Africa
    Biochem J 347:711-8. 2000
    ....
  70. ncbi The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme
    A Rousseau
    Centre National de la Recherche Scientifique, Institut de Chimie des Substances Naturelles, Gif Yvette, France
    J Biol Chem 270:3656-61. 1995
    ....
  71. ncbi Myocardial infarction increases ACE2 expression in rat and humans
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
    Eur Heart J 26:369-75; discussion 322-4. 2005
    ..We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts...
  72. ncbi Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study
    Pasquale Strazzullo
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Ann Intern Med 138:17-23. 2003
    ..The renin-angiotensin system is involved in adipocyte growth and differentiation and possibly in adipose tissue metabolism...
  73. ncbi Epitope mapping of mAbs to denatured human testicular ACE (CD143)
    I V Balyasnikova
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA
    Tissue Antigens 72:354-68. 2008
    ..Their high reactivity in paraffin-embedded tissues provides opportunities to study changes in the pattern of ACE expression and glycosylation (particularly with mAb 5B9) in different tissues and cells...
  74. ncbi Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys
    H Zhang
    Department of Medicine III, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 780 8558, Japan
    J Biol Chem 276:17132-9. 2001
    ....
  75. ncbi Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice
    Kenneth E Bernstein
    Department of Pathology and Laboratory of Medicine, Emory University, Atlanta, GA 30322, USA
    Circ Res 96:1135-44. 2005
  76. ncbi Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II
    C Karlsson
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 83:3925-9. 1998
    ..This opens the possibility that angiotensinogen-derived peptides, produced in adipose tissue itself, may affect adipogenesis and play a role in the pathogenesis of obesity...
  77. ncbi Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes
    Minghao Ye
    Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    J Am Soc Nephrol 17:3067-75. 2006
    ....
  78. ncbi High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells
    D B Vidotti
    Renal Div, UNIFESP, Rua Botucatu, 740, 04023 900 São Paulo, Brazil
    Am J Physiol Renal Physiol 286:F1039-45. 2004
    ..The consistent upregulation of ACE mRNA suggests that, besides renin, ACE is directly involved in the increased mesangial ANG II generation induced by HG...
  79. ncbi Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme: a major risk factor and a marker of risk for coronary stent restenosis
    F Ribichini
    Cardiac Catheterization Unit, Ospedale Santa Croce, Cuneo, Italy
    Circulation 97:147-54. 1998
    ..The association among restenosis within coronary stents, plasma ACE level, and the I/D polymorphism is analyzed in the present prospective study...
  80. ncbi Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease
    Ryuji Fukazawa
    Department of Pediatrics, Nippon Medical School, 113 8603 Tokyo, Japan
    Pediatr Res 56:597-601. 2004
    ..These results suggested that the renin-angiotensin system is associated with the formation of severe coronary artery stenosis and myocardial ischemia...
  81. ncbi Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  82. ncbi Monoclonal antibodies to denatured human ACE (CD 143), broad species specificity, reactivity on paraffin sections, and detection of subtle conformational changes in the C-terminal domain of ACE
    I V Balyasnikova
    Department of Anesthesiology, University of Illinois at Chicago, IL 60612, USA
    Tissue Antigens 61:49-62. 2003
    ..Their reactivity in routinely processed tissues of various species may prove useful for correlation of ACE expression in animal models to human diseases...
  83. ncbi Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster
    M J Cornell
    Department of Pure and Applied Biology, University of Leeds, United Kingdom
    J Biol Chem 270:13613-9. 1995
    ..6 x 10(-9) M) and trandolaprilat (IC50 = 2 x 10(-8) M). The evolutionary significance of these results is discussed...
  84. ncbi ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells
    Priscila C Cristovam
    Department of Medicine Renal Division, Federal University of Sao Paulo, Sao Paulo, Brazil
    Exp Biol Med (Maywood) 233:1035-43. 2008
    ....
  85. ncbi Renal ACE2 expression in human kidney disease
    A T Lely
    Department of Nephrology, Groningen University Medical Centre, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Pathol 204:587-93. 2004
    ..Further studies should elucidate the possible protective mechanisms involved in the de novo expression of ACE2 in renal disease...
  86. ncbi Skeletal muscle RAS and exercise performance
    Alun Jones
    Department of Cardiovascular Genetics, 3rd Floor, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Int J Biochem Cell Biol 35:855-66. 2003
    ....
  87. pmc Localisation of renin-angiotensin system (RAS) components in breast
    M Tahmasebi
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Br J Cancer 95:67-74. 2006
    ..3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer...
  88. ncbi Angiotensin-converting enzyme 2--a new cardiac regulator
    Manfred Boehm
    National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    N Engl J Med 347:1795-7. 2002
  89. pmc The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients
    Christoph Rocken
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Neoplasia 9:716-22. 2007
    ..Our study shows that ACE is differentially expressed in CRCs and that gene polymorphism is associated with gender-specific differences in primary tumor size and patient survival...
  90. pmc Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion
    Daniel R Beniac
    Viral Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 2:e1082. 2007
    ..The SARS-CoV spike provides an ideal model system to study receptor binding and membrane fusion in the native state, employing cryo-electron microscopy and single-particle image analysis...
  91. ncbi Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Donna K Arnett
    University of Minnesota, Division of Epidemiology, Minneapolis, USA
    Circulation 111:3374-83. 2005
    ....
  92. ncbi ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala
    Kristel Sleegers
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 26:1153-9. 2005
    ..Vascular pathology was not significantly associated with ACE. This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors...
  93. ncbi Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression
    L Burchill
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia
    Exp Physiol 93:622-30. 2008
    ....
  94. ncbi Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility
    C R Esther
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Lab Invest 74:953-65. 1996
    ..ACE-deficient animals demonstrate the role of this enzyme in systemic blood pressure, renal development and function, and male fertility...
  95. ncbi Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    D M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Circulation 103:1644-8. 2001
    ....
  96. ncbi New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy
    Daniel Batlle
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Nephrol Hypertens 17:250-7. 2008
    ....
  97. ncbi Association between angiotensin-converting enzyme gene polymorphisms and diabetic nephropathy: case-control, haplotype, and family-based study in three European populations
    Samy Hadjadj
    CHU de Poitiers, Department of Diabetology, Poitiers University Hospital, Poitiers, France
    J Am Soc Nephrol 18:1284-91. 2007
    ..This study population is suitable to search for additional candidate genes for DN...
  98. ncbi The secret life of ACE2 as a receptor for the SARS virus
    Dimiter S Dimitrov
    Human Immunovirology and Computational Biology Group, LECB, CCR, NCI Frederick, NIH, Frederick, MD 21702, USA
    Cell 115:652-3. 2003
    ..Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion...
  99. ncbi Angiotensin-converting enzyme insertion-deletion polymorphism in normotensive and pre-eclamptic pregnancies
    L Morgan
    Clinical Chemistry Division, School of Clinical Laboratory Sciences, University Hospital, Nottingham, UK
    J Hypertens 17:765-8. 1999
    ..To investigate the hypothesis that pre-eclampsia is associated with a common insertion-deletion polymorphism in the angiotensin-converting enzyme gene...
  100. pmc Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis
    S Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Heart 89:1195-9. 2003
    ..To test the hypothesis that gene-gene interaction of the renin-angiotensin system is associated with an effect on the extent of coronary atherosclerosis...
  101. ncbi DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans
    R Butler
    University Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Hypertension 33:1164-8. 1999
    ..These data demonstrate that the DD ACE genotype in a young population is associated with a blunting of stimulated endothelial NO and donated NO responses but not to non-NO vasodilators or vasoconstrictors...

Research Grants62

  1. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..In this proposal we will test the hypothesis that the endogenous RAAS impairs peripheral insulin sensitivity, hepatic insulin sensitivity, and insulin secretion in humans via aldosterone. ..
  2. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
  3. Role of Chymase In The Post-Myocardial Infarction Heart
    Ahsan Husain; Fiscal Year: 2013
    ..The proposed identification of the downstream targets of chymase should provide a foundation for the development of novel therapeutic agents directed toward patients with cardiovascular disease. ..
  4. ACE and ACE2 in Glomerular Angiotensin Peptides Metabolism
    JAN ANDRZEJ WYSOCKI; Fiscal Year: 2010
    ..This proposal will provide a better understanding of ACE and ACE2 in diabetic kidney disease and has the promise to offer novel insights into ways to protect the kidney from diabetes related damage. ..
  5. Renin Angioensin Aldosterone System in Drub Abuse and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
    ..Based on our preliminary data, we hypothesize that modulation of RAAS by its selective inhibitors will not only prevent or attenuate HIV-1- induced renal injury but also delay or slow down the progression of HIVAN. ..
  6. Vasoactive Peptides that Stimulate Smooth Muscles
    RANDAL A contact SKIDGEL; Fiscal Year: 2010
    ..abstract_text> ..
  7. CONTROL OF THE CIRCULATION DURING THERMAL STRESS
    DUANE PROPPE; Fiscal Year: 1991
    ..These renal flow studies will enhance understanding of control of a vascular bed that may be involved in producing some forms of hypertension...
  8. ANGIOTENSIN II--AN INTRAOVARIAN REGULATORY PEPTIDE
    Ahsan Husain; Fiscal Year: 1992
    ..The studies proposed are designed to provide the first steps toward defining the role of Ang II in ovarian function, and should ultimately prove to be useful in understanding the follicular selection processes in the human ovary...
  9. GASTROINTESTINAL KALLIKREIN AND RENIN SYSTEMS
    Patrick Ward; Fiscal Year: 1990
    ..Such studies may eventually lead to development of drugs (inhibitors) which, via attenuation or potentiation of endogenous peptides, are of clinical value in the treatment of variety of pathologic conditions...
  10. PHYSIOLOGIC RESPONSES TO CHRONIC COLD EXPOSURE
    M Phillips; Fiscal Year: 1999
    ....
  11. PROLIFERATION AND FUNCTION IN HUMAN ENDOTHELIAL CELLS
    ELLIOT LEVINE; Fiscal Year: 1990
    ..4. After sufficient progress has been made in achieving the above goals, possible effects of vascular site, donor age and sex, and in vitro cultivation on function and proliferation in culture human EC will be investigated...
  12. SEPARATE ACTIVE DOMAINS OF ANGIOTENSIN CONVERTING ENZYME
    ERVIN ERDOS; Fiscal Year: 2000
    ..Ultimately, the experiments should lead to a better understanding of the structure and function of ACE and the therapeutic applications of the inhibitors. ..
  13. METABOLISM OF PEPTIDES BY HUMAN LUNG ENZYMES
    ERVIN ERDOS; Fiscal Year: 1993
    ..Specific inhibitors of peptidases will also be used to characterize the enzymes involved...
  14. NHLBI MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    Scott Williams; Fiscal Year: 2000
    ..This design will detect any associations with these genes and hypertension. As new data become available, other candidate genes will also be analyzed in these subjects. ..
  15. EXPRESSION OF ACE IN SHEAR STRESSED ENDOTHELIAL CELLS
    KAREN FRASIER SCOTT; Fiscal Year: 1990
    ..Cells subjected to these conditions will then be assayed for ACE activity using a radiolabeled synthetic substrate and monoclonal antibodies developed by our laboratory...
  16. VASCULAR SMOOTH MUSCLE CELLS: PATHOPHYSIOLOGY
    MICHAEL GIMBRONE; Fiscal Year: 1991
    ..The above studies will be extended to vascular preparations obtained from spontaneously hypertensive rats and rats with experimentally-induced alterations in renin-angiotensin system activity...
  17. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004
    ..The proposed research will uncover novel mechanisms of atherogenesis that may have significant impact in the development of new therapeutic modalities applicable to cardiovascular and blood vessel diseases. ..
  18. Estrogen, ACE2 and Salt-Sensitivity
    Mark Chappell; Fiscal Year: 2008
    ..Lewis strain. ..
  19. Robotics Extraction System/HPLC for Shared Resource Lab
    Mark Chappell; Fiscal Year: 2005
    ..abstract_text> ..
  20. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2003
    ..In addition, plasma markers that predict risk of recurrent stroke may indicate novel therapies to prevent this condition. ..
  21. Role of Ang-(1-7) in normal and hypertensive pregnancy
    K Brosnihan; Fiscal Year: 2003
    ..The major goal of these studies is to understand the contribution of the vasodilator component of the RAAS to blood pressure regulation in normal pregnancy. ..
  22. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2005
    ..Receptor activation will be assessed by measuring arachidonic acid release, ..
  23. Training Program in Molecular Medicine
    KATHLEEN BROSNIHAN; Fiscal Year: 2008
    ..This training grant will allow continued growth and recruitment of the most competitive applicants and minorities into the Program. [unreadable] [unreadable]..
  24. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  25. Defining an Obesity QTL on Chromosome 3q
    Xiaofeng Zhu; Fiscal Year: 2007
    ..The methodologies applied have been used successfully to identify unique sequence variants in linkage peaks and to conduct fine mapping with specific physiologic candidate genes. ..
  26. Gender and susceptibility to kidney damage in high BP
    Jane F Reckelhoff; Fiscal Year: 2010
    ....
  27. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    ..These studies promise to provide important information regarding the effects of drugs that interrupt the RAS and generate new strategies to reduce morbidity in patients undergoing CPB. ..
  28. CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIEN
    Daniel Batlle; Fiscal Year: 2002
    ....
  29. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  30. Genetic and Environmental Determinants of Triglycerides
    Donna Arnett; Fiscal Year: 2008
    ..Genotypic characterization of individuals who respond favorably to fenofibrate may enable targeted interventions to reduce TGs and identify the most effective treatments in clinical practice. [unreadable] [unreadable] [unreadable]..
  31. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  32. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..
  33. Dissection of cellular interactions with integrated functional genomics in comple
    Martin Hessner; Fiscal Year: 2008
    ..Understanding the relationship between mast cells, T effector, and TREG cells in autoimmunity and has the potential to establish a new paradigm for immune regulation and create new insights to human disease. ..
  34. PRESSURE NATRIURESIS MEDIATED BY EXTRACELLULAR cGMP
    Robert Carey; Fiscal Year: 2009
    ..Proof of the specific aims will identify and characterize a novel role of extracellular Rl cGMP and provide a potential therapeutic target for hypertension and other disease states associated with sodium retention. ..
  35. AT2 RECEPTOR MECHANISMS IN ANG II DEPENDENT HYPERTENSION
    Robert Carey; Fiscal Year: 2001
    ..The proposed studies will provide for the first time in any form of hypertension an understanding of the relevance and mediators of AT2 receptors in the long term control of blood pressure and kidney function. ..
  36. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 2001
    ....
  37. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..
  38. Pathogenesis of Experimental Autoimmune Myocarditis
    David M Engman; Fiscal Year: 2010
    ....
  39. Genetic Epidemiology of Multiple Sclerosis
    Jonathan L Haines; Fiscal Year: 2010
    ..We will take advantage of our unique large multiplex family dataset to sequence MS cases most likely to carry rare variants of strong effect. ..
  40. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  41. Vitamin D, falls, fractures and function in community-dwelling older adults
    Stephen Kritchevsky; Fiscal Year: 2009
    ....
  42. Natriuretic mechanisms of AT2 receptors
    ROBERT MUNSON CAREY; Fiscal Year: 2010
    ..This application will increase our understanding of the mechanisms whereby the kidney renin-angiotensin system regulates salt and water excretion, suggesting new molecular targets for the treatment and prevention of hypertension. ..
  43. Epidemiology of Diabetes Complication:Phase II
    Trevor Orchard; Fiscal Year: 2008
    ..This study will continue to advance our knowledge of diabetes complications and lead to appropriate preventive strategies. ..
  44. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  45. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  46. Diet and Exercise: Race, Postmenopause and Metabolism
    ALICE RYAN; Fiscal Year: 2005
    ..These findings may provide a rationale for targeting specific populations of women who might improve glucose and fat metabolism more from the addition of exercise to hypocaloric weight loss than weight loss alone. ..
  47. Informatics Support to Enhance Human Subjects Research
    John Burnett; Fiscal Year: 2003
    ..We also will work with both Olmsted Medical Center and Luther Midelfort in evaluation of standardized procedures. We plan to share our best practices with all three of these institutions at the conclusion of the grant. ..
  48. TRYPANOSOME FLAGELLAR CALCIUM ACYL SWITCH PROTEINS
    DAVID ENGMAN; Fiscal Year: 2004
    ....
  49. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM
    John Burnett; Fiscal Year: 2004
    ..In summary, the new IIRF will strategically position Mayo's research effort in the new millennium, enabling NIH-level imaging research across multiple imaging modalities in one facility. ..
  50. Maternal/fetal genotype incompatibility in schizophrenia
    Janet Sinsheimer; Fiscal Year: 2003
    ..This proposal is important because it could lead to a concrete research model in which the essential genetic and environmental elements involved in the etiology of schizophrenia could be studied precisely. ..
  51. PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITION
    CHARLES STIER; Fiscal Year: 2003
    ..abstract_text> ..
  52. Training CAM Clinical Investigators
    Richard Grimm; Fiscal Year: 2006
    ..Dr. Richard Grimm is Program Director. The Program will produce a highly trained cadre of clinical investigators with the knowledge and experience to becoming leading researchers in CAM. ..
  53. Excellence in Cardiovascular Sciences Summer Research
    Debra Diz; Fiscal Year: 2007
    ..Moreover, all students regarded the experience as a positive influence on their career and 76% of those who responded said they plan to pursue some aspect of biomedical research as a career. ..
  54. Central ACE2, Blood Pressure Regulation and Hypertension
    Eric Lazartigues; Fiscal Year: 2008
    ..Evidence of a role of ACE2 in the regulation of BP could lead to the development of new therapeutics as well as a better utilization of existing therapeutics for the treatment of hypertension and other CV diseases. ..
  55. Genetic Modulation of Left Ventricular Recovery
    Dennis McNamara; Fiscal Year: 2008
    ..Specific Aim 3 will examine other genetic loci which act as modifiers of the cytokine and neurohomonal response, in particular NOS2, NOS3 and aldosterone synthase. ..
  56. Progression of Cardiovascular Disease in TID: CADRE/EDC
    Trevor Orchard; Fiscal Year: 2007
    ..This study will help advance our knowledge of CAD in T1D and hopefully lead to appropriate preventative strategies. ..
  57. TRAINING A NEW GENERATION OF CAM CLINICAL INVESTIGATORS
    Richard Grimm; Fiscal Year: 2006
    ..abstract_text> ..
  58. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. Genetic risk factors for Sudden Cardiac Death
    Nona Sotoodehnia; Fiscal Year: 2007
    ....
  60. Glycogen Synthase Kinase-3 and Muscle Insulin Resistance
    ERIK HENRIKSEN; Fiscal Year: 2007
    ..abstract_text> ..
  61. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    ..abstract_text> ..
  62. GALACTOSYLTRANSFERASES--STRUCTURE AND REGULATION
    Keith Brew; Fiscal Year: 2003
    ..The activity and structure will be investigated using a recombinant form of this protein. ..