igg receptors

Summary

Summary: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).

Top Publications

  1. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
  2. ncbi Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    R A Clynes
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Nat Med 6:443-6. 2000
  3. ncbi Mechanisms of phagocytosis in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Annu Rev Immunol 17:593-623. 1999
  4. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
  5. ncbi Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene
    Guillaume Cartron
    Service d Oncologie Médicale et Maladies du Sang et Laboratoire d Immunologie, Centre Hospitalier Régional et Universitaire de Tours, 37044 Tours Cedex, France
    Blood 99:754-8. 2002
  6. ncbi Fcgamma receptors: old friends and new family members
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York 10021, USA
    Immunity 24:19-28. 2006
  7. ncbi The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex
    P Sondermann
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Nature 406:267-73. 2000
  8. ncbi Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 313:670-3. 2006
  9. ncbi The structure of a human type III Fcgamma receptor in complex with Fc
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 276:16469-77. 2001
  10. ncbi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004

Detail Information

Publications272 found, 100 shown here

  1. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
    ..Collectively, the data demonstrate that TMPD-stimulated IFN-I production requires TLR7/MyD88 signaling and is independent of autoantibody-mediated uptake of ribonucleoproteins by FcgammaRs...
  2. ncbi Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    R A Clynes
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Nat Med 6:443-6. 2000
    ....
  3. ncbi Mechanisms of phagocytosis in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Annu Rev Immunol 17:593-623. 1999
    ..Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response...
  4. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
    ..The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease...
  5. ncbi Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene
    Guillaume Cartron
    Service d Oncologie Médicale et Maladies du Sang et Laboratoire d Immunologie, Centre Hospitalier Régional et Universitaire de Tours, 37044 Tours Cedex, France
    Blood 99:754-8. 2002
    ..This finding will certainly give rise to new pharmacogenetic approaches to the management of patients with non-Hodgkin lymphomas...
  6. ncbi Fcgamma receptors: old friends and new family members
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York 10021, USA
    Immunity 24:19-28. 2006
    ..This review will summarize recent results in Fc-receptor biology with an emphasis on data obtained in in vivo model systems...
  7. ncbi The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex
    P Sondermann
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Nature 406:267-73. 2000
    ..Thus the described structure is a model for immune complex recognition and helps to explain the vastly differing affinities of other Fc gammaR-IgG complexes and the Fc epsilonRI alpha-IgE complex...
  8. ncbi Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 313:670-3. 2006
    ..This differential sialylation may provide a switch from innate anti-inflammatory activity in the steady state to generating adaptive pro-inflammatory effects upon antigenic challenge...
  9. ncbi The structure of a human type III Fcgamma receptor in complex with Fc
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 276:16469-77. 2001
    ..An antibody-FcgammaRIII model suggests two possible ligand-induced receptor aggregations...
  10. ncbi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  11. pmc Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo
    Joke M M den Haan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    J Exp Med 196:817-27. 2002
    ..Cross-presentation of immune complexes may play an important role in autoimmune diseases and the therapeutic effect of antitumor antibodies...
  12. ncbi The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoforms
    Claudia Ferrara
    GLYCART Biotechnology AG Roche Group, Wagistrasse 18, CH 8952 Schlieren, Switzerland
    J Biol Chem 281:5032-6. 2006
    ..This information can be exploited for the design of new antibodies with altered Fc receptor binding affinity and enhanced therapeutic potential...
  13. ncbi Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
    Timothy J Aitman
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nature 439:851-5. 2006
    ....
  14. ncbi Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype
    H R Koene
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, and Academic Medical Centre
    Blood 90:1109-14. 1997
    ..In conclusion, the previously reported differences in IgG binding among the three Fc gammaRIIIa-48L/R/H isoforms are a consequence of the linked, biallelic Fc gammaRIIIa-158V/F polymorphism at amino-acid position 158...
  15. ncbi Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852
    Cell 75:969-76. 1993
    ..Therefore, interfering with its function should be an effective means of treating allergy, regardless of the allergen specificity...
  16. pmc A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease
    J Wu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 100:1059-70. 1997
    ..Thus, the FcgammaRIIIa polymorphism at residue 176 appears to impact directly on human biology, an effect which may extend beyond autoimmune disease characterized by immune complexes to host defense mechanisms...
  17. ncbi Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor
    A Samuelsson
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 291:484-6. 2001
    ..Modulation of inhibitory signaling is thus a potent therapeutic strategy for attenuating autoantibody-triggered inflammatory diseases...
  18. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
    ..Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity...
  19. pmc Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
    I Miyajima
    Department of Pathology, Beth Israel Deaconess Medical Center East and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:901-14. 1997
    ....
  20. ncbi Neutrophil CD64 (FcgammaRI) expression is a specific marker of bacterial infection: a study on the kinetics and the impact of major surgery
    Gustav Fjaertoft
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Scand J Infect Dis 39:525-35. 2007
    ..Neutrophil expression of CD64, therefore, seems to be a promising tool for the early detection of bacterial infections even during surgery...
  21. pmc Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases
    Naotake Tsuboi
    Center of Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunity 28:833-46. 2008
    ....
  22. pmc Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy
    Yasuhito Hamaguchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:743-53. 2006
    ..Thus, isotype-specific mAb interactions with distinct FcgammaRs contribute significantly to the effectiveness of CD20 mAbs in vivo, which may have important clinical implications for CD20 and other mAb-based therapies...
  23. pmc Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions
    Adam M Boruchov
    Laboratory of Cellular Immunobiology, Hematology Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 115:2914-23. 2005
    ..The data also suggest novel strategies for targeting antigens to the activating or inhibitory FcgammaRs on human DCs to generate either antigen-specific immunity or tolerance...
  24. pmc Interleukin-10 induces macrophage apoptosis and expression of CD16 (FcgammaRIII) whose engagement blocks the cell death programme and facilitates differentiation
    Z Q Wang
    Departments of Microbiology and Immunology, and Medicine, New York Medical College, Valhalla, NY 10595, USA
    Immunology 102:331-7. 2001
    ....
  25. pmc Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury
    Mark R Looney
    Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 116:1615-23. 2006
    ..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors...
  26. ncbi FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection
    A Ioan-Facsinay
    Department of Human Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Immunity 16:391-402. 2002
    ..We conclude that FcgammaRI contributes substantially to a variety of IgG2a-IC-dependent immune functions and immunopathological responses...
  27. ncbi Fc receptors and their interaction with complement in autoimmunity
    Reinhold E Schmidt
    Abteilung fur Klinische Immunologie, Medizinische Hochschule Hannover, Labor für Molekulare Immunologie, Carl Neuberg Str 1, Hannover 30625, Germany
    Immunol Lett 100:56-67. 2005
    ..This connecting pathway is now proposed to be a promising new therapeutic target for the treatment of inflammation and autoimmune disease in both mice and humans...
  28. pmc Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria
    Menna R Clatworthy
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 104:7169-74. 2007
    ....
  29. pmc Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors
    S Kleinau
    Department of Genetics and Pathology, Uppsala University, S 75185 Uppsala, Sweden
    J Exp Med 191:1611-6. 2000
    ..In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis...
  30. ncbi IgG Fc receptors
    J V Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Annu Rev Immunol 19:275-90. 2001
    ..Fc gamma Rs offer a paradigm for the biological significance of balancing activation and inhibitory signaling in the expanding family of activation/inhibitory receptor pairs found in the immune system...
  31. ncbi Inflammation in autoimmunity: receptors for IgG revisited
    H M Dijstelbloem
    Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Trends Immunol 22:510-6. 2001
    ..Comprehending the complex interactions between activating and inhibitory Fc gamma receptors might lead to new therapeutic approaches for human diseases, including SLE...
  32. ncbi Delineating the genetic basis of systemic lupus erythematosus
    E K Wakeland
    Center for Immunology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Immunity 15:397-408. 2001
    ..Genes in multiple pathways appear to participate in specific elements of the disease, and epistatic interactions among these genes play an important role in both aggravating and suppressing disease development...
  33. pmc IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 116:833-41. 2006
    ....
  34. pmc Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I
    F S Sutterwala
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Exp Med 188:217-22. 1998
    ..This reciprocal alteration in the pattern of macrophage cytokine production illustrates a potentially important role for FcgammaR-mediated clearance in suppressing macrophage proinflammatory responses...
  35. ncbi Peripheral blood CD14high CD16+ monocytes are main producers of IL-10
    J Skrzeczynska-Moncznik
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland
    Scand J Immunol 67:152-9. 2008
    ..In conclusion, our data show that human peripheral blood CD16(+) MO are heterogeneous in function and consist of two subpopulations: CD14(dim) CD16(+) pro-inflammatory and CD14(high) CD16(+) with anti-inflammatory potential...
  36. ncbi Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors
    D Wang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 13:25-35. 2000
    ..The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors...
  37. ncbi Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles
    Akira Yamauchi
    Inha University College of Medicine, Incheon, Korea
    J Immunol 173:5971-9. 2004
    ..These results provide genetic evidence that although Rac2 is a relatively minor isoform in murine macrophages, it plays a nonoverlapping role with Rac1 to regulate host defense functions in this phagocyte lineage...
  38. ncbi Divergent immunoglobulin g subclass activity through selective Fc receptor binding
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 310:1510-2. 2005
    ..We suggest that these highly predictable functions assigned by Fc binding will be an important consideration in the design of therapeutic antibodies and vaccines...
  39. ncbi Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses
    D Dombrowicz
    Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 8:517-29. 1998
    ....
  40. ncbi The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF
    Kai Uwe Belge
    Institute for Immunology, University of Muenchen, Germany
    J Immunol 168:3536-42. 2002
    ..This indicates that the minor population of CD14(+)CD16(+) monocytes are major producers of TNF in human blood...
  41. ncbi The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs
    Derry C Roopenian
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 170:3528-33. 2003
    ..FcRn is therefore a promising therapeutic target for enhancing protective humoral immunity, treating autoimmune disease, and improving drug efficacy...
  42. ncbi Fc-receptors as regulators of immunity
    Falk Nimmerjahn
    Laboratory for Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Erlangen 91054, Germany
    Adv Immunol 96:179-204. 2007
    ..Moreover, we will focus on exogenous factors that can influence the balanced triggering of activating and inhibitory FcRs, such as the cytokine milieu and the role of differential antibody glycosylation...
  43. pmc Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB
    Stefka B Petkova
    The Jackson Laboratory, Bar Harbor, ME 04605, USA
    J Exp Med 203:275-80. 2006
    ..Our results suggest that humoral autoimmunity can contribute directly to autoimmune arthritis, and that FcgammaRIIB-/- mice are a promising model to evaluate the arthritogenic potential of human autoAbs...
  44. pmc The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations
    Hongbo Wang
    Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, USA
    Blood 110:1530-9. 2007
    ..Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects...
  45. pmc Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages
    Maria Diakonova
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    Mol Biol Cell 13:402-11. 2002
    ..These results suggest that PI 3-kinase deactivates PAK1, and that this may be needed for phagosome closure...
  46. ncbi Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16)
    W L Hazenbos
    Department of Immunology, University Hospital Utrecht, The Netherlands
    J Immunol 161:3026-32. 1998
    ..Together, these results demonstrate that IgG1 complexes, either in particulate or in soluble form, trigger in vitro and in vivo immune effector functions in mice predominantly via Fc gamma RIII...
  47. ncbi FcR gamma chain deletion results in pleiotrophic effector cell defects
    T Takai
    DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
    Cell 76:519-29. 1994
    ..These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses...
  48. ncbi Comparison of neutrophil CD64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis
    Bruce H Davis
    Trillium Diagnostics, LLC, Scarborough, Maine, USA
    Lab Hematol 11:137-47. 2005
    ....
  49. ncbi Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets
    Diego Piccioli
    Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy
    Blood 109:5371-9. 2007
    ..In conclusion, CD16-mDCs show strong proinflammatory activity, whereas CD1c-mDCs appear to be mainly inducers of chemotaxis...
  50. ncbi Allelic polymorphisms of human fcgamma receptor IIa and Fcgamma receptor IIIb among distinct groups in Brazil
    S T Kuwano
    Hematology and Transfusion Medicine Service and the Endocrinology Service, Paulista School of Medicine, Federal University of Sao Paulo, Brazil
    Transfusion 40:1388-92. 2000
    ..An additional polymorphism is the SH antigen that is associated with the FCGR3B3 (FcgammaRIIIB-SH) allele...
  51. ncbi Cross-linking of CD32 induces maturation of human monocyte-derived dendritic cells via NF-kappa B signaling pathway
    Zoltan Banki
    Institute of Hygiene and Social Medicine, Leopold Franzens University and Ludwig Boltzmann Institute for AIDS Research, Innsbruck, Austria
    J Immunol 170:3963-70. 2003
    ....
  52. pmc A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus
    Lisa C Willcocks
    Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 107:7881-5. 2010
    ..56; P = 7.1 x 10(-5)). This protective effect against malaria may contribute to the higher frequency of this SNP and hence, SLE in Africans and Southeast Asians...
  53. ncbi Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B
    Willemijn B Breunis
    Department of Pediatric Hematology, Immunology and Infectious Disease at Emma Children s Hospital, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    Hum Mutat 30:E640-50. 2009
    ..In conclusion, we report a novel CNV of the FCGR3A gene that correlates with FcgammaRIIIa expression and function on NK cells. Only FCGR3A, FCGR2C and FCGR3B show CNV, in contrast to FCGR2A and FCGR2B...
  54. ncbi Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation
    M Torti
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 274:13690-7. 1999
    ..Our results indicate that translocation of Rap1B and Rap2B to the cytoskeleton is regulated by tyrosine kinases and suggest a novel role for the FcgammaII receptor in the mechanism of platelet activation by vWF...
  55. pmc B cell inhibitory receptors and autoimmunity
    Nicholas R Pritchard
    Cambridge Institute for Medical Research and the Department of Medicine, Wellcome Trust MRC Building, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Immunology 108:263-73. 2003
  56. pmc Fc gamma receptors and cross-presentation in dendritic cells
    Sebastian Amigorena
    INSERM U520, Institut Curie, 75005 Paris, France
    J Exp Med 195:F1-3. 2002
  57. ncbi Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 168:3697-701. 2002
    ..These studies demonstrate that the ligation of FcgammaR on activated macrophages can reverse the Th1 biasing that occurs as a result of innate immune responses to microbial products...
  58. ncbi Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes
    Gianluca Fossati
    University of Liverpool, Liverpool, UK
    Arthritis Rheum 46:1351-61. 2002
    ....
  59. ncbi Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs
    C Mold
    Department of Molecular Genetics and Microbiology, Veterans Affairs Medical Center, and Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    J Immunol 166:1200-5. 2001
    ..The use of FcgammaR by the pentraxins links innate and adaptive immunity and may have important consequences for processing, presentation, and clearance of the self-Ags to which these proteins bind...
  60. ncbi Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptor
    I Canobbio
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 276:26022-9. 2001
    ..These results indicate that PLC gamma 2 plays a central role in platelet activation by vWF and that the stimulation of this enzyme requires coordinated signals through endogenous TxA(2) and Fc gamma RIIA...
  61. pmc Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    PLoS ONE 5:e11049. 2010
    ....
  62. pmc Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII
    F Takizawa
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852
    J Exp Med 176:469-75. 1992
    ..These data demonstrate that mouse Fc gamma RII and Fc gamma RIII are not isotype specific, and that the binding of IgE-immune complexes to these receptors induces cell activation...
  63. pmc A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18)
    D Cox
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Exp Med 193:61-71. 2001
    ..We conclude that PI 3-kinase(s) and SHIP regulate multiple forms of phagocytosis and that endogenous SHIP plays a role in modulating beta(2) integrin outside-in signaling...
  64. pmc Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III
    L Fossati-Jimack
    Department of Pathology, University of Geneva, 1211 Geneva 4, Switzerland
    J Exp Med 191:1293-302. 2000
    ....
  65. ncbi Phagocytosis and the actin cytoskeleton
    R C May
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    J Cell Sci 114:1061-77. 2001
    ..Similarly, a wide diversity of 'effector molecules' are now implicated in actin-remodelling downstream of these receptors...
  66. ncbi IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice
    S Wernersson
    Department of Genetics and Pathology, Uppsala University, Sweden
    J Immunol 163:618-22. 1999
    ..Our observations suggest that IgG/Ag complexes enhance Ab responses via Fc gamma Rs. Moreover, they reveal a strong negative regulation of Ab responses to IgG/Ag exerted by Fc gamma RII...
  67. ncbi Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase
    Farazeela Bte Mohd Ibrahim
    Department of Physiology, National University of Singapore, Singapore 117597
    J Biol Chem 279:44802-11. 2004
    ....
  68. pmc Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
    D Cox
    Pulmonary Division, Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA
    J Exp Med 186:1487-94. 1997
    ....
  69. pmc Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells
    Sang Taek Jung
    Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 107:604-9. 2010
    ..These results indicate that aglycosylated IgGs can be engineered to display unique FcgammaR selectivity profiles that, in turn, mediate ADCC via mechanisms that are not normally displayed by glycosylated monoclonal antibodies...
  70. ncbi High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R
    R L Shields
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 276:6591-604. 2001
    ..Huber, R., Oosthuizen, V., and Jacob, U. (2000) Nature 406, 267-273). These engineered antibodies may have important implications for improving antibody therapeutic efficacy...
  71. ncbi Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype
    Wen Kai Weng
    Division of Oncology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305 5306, USA
    J Clin Oncol 22:4717-24. 2004
    ..In this study, we tested whether anti-Id immune responses or FcgammaR polymorphisms associate with clinical outcome of patients who received Id vaccination...
  72. pmc Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the systemic inflammatory response syndrome (SIRS)
    S S Qureshi
    Department of Immunobiology, Guy's, King's and St Thomas's Hospitals Medical and Dental School (GKT, London, UK
    Clin Exp Immunol 125:258-65. 2001
    ....
  73. ncbi The mast cell IgG receptors and their roles in tissue inflammation
    Odile Malbec
    Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Institut Pasteur, Paris, France
    Immunol Rev 217:206-21. 2007
    ..Mast cell FcRs include immunoglobulin E (IgE) and IgG receptors and, among these, activating and inhibitory receptors...
  74. ncbi Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    ..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
  75. pmc Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions
    J V Ravetch
    DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
    J Exp Med 170:481-97. 1989
    ..The allelic sites have been mapped to two single nucleotides in the extracellular domain. These genes are transcribed in a cell type-specific fashion to generate the alternatively anchored forms of this receptor...
  76. ncbi IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation
    R Jefferis
    Department of Immunology, Medical School, University of Birmingham, Edgbaston, UK
    Immunol Rev 163:59-76. 1998
    ....
  77. ncbi FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses
    Nadine Barnes
    The Austin Research Institute, Kronheimer Building, Studley Road, Heidelberg, Victoria 3084, Australia
    Immunity 16:379-89. 2002
    ..In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI. Thus, FcgammaRI is an early participant in Fc-dependent cell activation and in the development of immune responses...
  78. pmc C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease
    Nelli Shushakova
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Clin Invest 110:1823-30. 2002
    ..Therefore, C5a, which is a potent chemoattractant, has a broader critical function in regulating the inhibitory/activating FcgammaRII/III receptor pair to connect complement and FcgammaR effector pathways in immune inflammation...
  79. pmc Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
    Eri Ishikawa
    Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Exp Med 206:2879-88. 2009
    ..These results demonstrate that Mincle is an essential receptor for the mycobacterial glycolipid, TDM...
  80. pmc Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    Terry K Means
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 115:407-17. 2005
    ....
  81. pmc Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
    Kavita M Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:2910-5. 2005
    ..These data suggest an approach for modifying this balance to enhance immunity to immune complexes and antibody-coated tumor cells and to silence DC activation by immune complexes in autoimmune states...
  82. pmc The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting
    Gwendalyn J Randolph
    The Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Exp Med 196:517-27. 2002
    ..We propose that CD16(+) monocytes may contribute significantly to precursors for DCs that transiently survey tissues and migrate to lymph nodes via afferent lymphatic vessels...
  83. pmc Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways
    Daniel Rittirsch
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 5:e1000464. 2009
    ..In conclusion, our findings suggest that TLR4 and FcgammaRIII pathways are structurally and functionally connected at the receptor level and that TLR4 is indispensable for FcgammaRIII signaling via FcRgamma-subunit activation...
  84. pmc Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans
    J E Salmon
    Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA
    J Clin Invest 97:1348-54. 1996
    ..The skewing in the distribution of Fc gamma RIIA alleles identifies this gene as a risk factor with pathophysiologic importance for the SLE diathesis in African Americans...
  85. ncbi Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanism for hu
    Mohammed Mullazehi
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 54:1759-71. 2006
    ....
  86. pmc Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 183:2678-87. 2009
    ..Our study demonstrates that functional CD14(+)CD16(-) and CD14(+)CD16(+) monocytes can be isolated from allogeneic hematopoietic stem cell transplantation donors and that these subsets differ in their response to A. fumigatus conidia...
  87. ncbi The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion
    Kazunobu Kato
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 102:1701-7. 2003
    ..These results illustrate the role of GP VI in postadhesion events leading to the development of platelet thrombi on collagen fibrils...
  88. pmc Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE
    J Ronnelid
    Department of Clinical Immunology, Rudbeck Laboratory, University Hospital, Uppsala University, S 751 85 Uppsala, Sweden
    Ann Rheum Dis 62:37-42. 2003
    ..These immune complexes can then stimulate cellular reactions through Fc and complement receptors...
  89. ncbi CD16+ and CD16- human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells
    C Sanchez-Torres
    Department of Molecular Biomedicine, Centro de Investigacion y de Estudios Avanzados, CINVESTAV IPN, Av IPN 2508, Mexico City 07360, Mexico
    Int Immunol 13:1571-81. 2001
    ....
  90. pmc Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals
    Domenico Mavilio
    Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2886-91. 2005
    ..These data suggest that the expansion of this highly dysfunctional CD56(-) NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total NK cell population...
  91. ncbi Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis
    Marco A Cassatella
    Department of Pathology, Division of General Pathology, University of Verona, Verona, Italy
    J Immunol 178:7325-33. 2007
    ....
  92. pmc Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis
    J G Marshall
    Division of Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Cell Biol 153:1369-80. 2001
    ..Two factors contribute to the rapid disappearance of 3'PI: the dissociation of the type I PI3K from the phagosomal membrane and the persistent accumulation of phosphoinositide phosphatases...
  93. ncbi Mincle is an ITAM-coupled activating receptor that senses damaged cells
    Sho Yamasaki
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Nat Immunol 9:1179-88. 2008
    ..Our results suggest that Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue...
  94. ncbi Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages
    Wei Xu
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:1594-9. 2007
    ..We propose that pMPhi have the potential to maintain an anti-inflammatory condition in the peritoneal cavity...
  95. pmc Engineered antibody Fc variants with enhanced effector function
    Greg A Lazar
    Xencor, Inc, 111 West Lemon Avenue, Monrovia, CA 91016, USA
    Proc Natl Acad Sci U S A 103:4005-10. 2006
    ..Our engineered Fc regions offer a means for improving the next generation of therapeutic antibodies and have the potential to broaden the diversity of antigens that can be targeted for antibody-based tumor therapy...
  96. ncbi Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, 42283 Wuppertal, Germany
    J Biol Chem 275:23998-4002. 2000
    ..These results strongly suggest that GPVI is the collagen receptor responsible for platelet activation in mice and demonstrate that the association with the FcRgamma chain is critical for its expression and function...
  97. ncbi The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells
    Massimo Vitale
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 34:1715-22. 2004
    ..This implies that, in vivo, the interactions between DC undergoing maturation and CD56(bright) NK cells may occur in different tissues and have different functional implications...
  98. ncbi 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells
    Knut Schakel
    Institute of Immunology, Technical University of Dresden, Dresden, Germany
    Immunity 17:289-301. 2002
    ..Thus, 6-sulfo LacNAc-expressing DCs appear as a novel proinflammatory DC subset...
  99. pmc Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice
    Silvia Bolland
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 195:1167-74. 2002
    ..In addition to these known modifier pathways, we have discovered two novel, recessive loci contributed by the C57BL/6 genome that are required for the ANA phenotype, further indicating the epistatic properties of this SLE model...
  100. ncbi Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    Wen Kai Weng
    Department of Internal Medicine, Stanford University School of Medicine, CA 94305, USA
    J Clin Oncol 21:3940-7. 2003
    ..Several Fc gamma R polymorphisms have been identified that may affect the killing function of natural killer cells and macrophages...
  101. pmc Neutrophil and monocyte CD64 and CD163 expression in critically ill neonates and children with sepsis: comparison of fluorescence intensities and calculated indexes
    Mojca Groselj-Grenc
    Department of Paediatric Surgery and Intensive Care, University Medical Center, Zaloska 7, 1525 Ljubljana, Slovenia
    Mediators Inflamm 2008:202646. 2008
    ....

Research Grants64

  1. Syk blockade in bullous skin diseases
    Uma Sinha; Fiscal Year: 2012
    ..with protein tyrosine kinase inhibitors (PTKis) selective for Syk, the PTK required for signaling of both IgG receptors (FcR) and the B cell receptor (BCR)...
  2. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..Previous studies have suggested that IgG inhibits IgE by interacting with inhibitory IgG receptors on basophils, although other studies have suggested instead that IgG may simply prevent allergen from binding ..
  3. MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISM
    Maria Lopes Virella; Fiscal Year: 2001
    ..Our overall objective is to provide insight into the mechanisms by which anti-LDL antibodies and macrophage activation may contribute to the development(acceleration of the arteriosclerotic process. ..
  4. IGE AND IGA IN HUMAN PHAGOCYTE FUNCTION
    LILIAN SHEN; Fiscal Year: 1990
    It is well established that IgG receptors are of major importance in promoting functions of mononuclear phagocytes. By contrast little is known concerning receptors for IgE and IgA on these cells...
  5. HUMAN BLOOD MONOCYTE RECEPTOR EXPESSION AND MODULATION
    Alan Schreiber; Fiscal Year: 2000
    ..The PI's hypothesis is that the extracellular domain of Fc-gamma-RI-alpha will enhance the clearance of IgG coated RBCs in vivo. ..
  6. MONONUCLEAR PHAGOCYTE FUNCTION IN IMMUNOLOGIC DISEASES
    Robert P Kimberly; Fiscal Year: 2010
    ..In humans, members of the three families of highly homologous IgG receptors (FcRI, FcRII, FcRIa) have typically been conceptualized as "activating" or "inhibitory" receptors...
  7. TARGETED IMMUNOTHERAPY FOR TUMOR EXPRESSING GRP RECEPTOR
    Tibor Keler; Fiscal Year: 2000
    ..Development of such therapeutics are greatly needed for SCCL for which currently available treatments provide only short-term remissions. ..
  8. IMMUNOLOGIC DISEASES--CELLULAR AND MOLECULAR MECHANISMS
    John Leddy; Fiscal Year: 1992
    ..These investigations receive impetus from an interest in the potential role of immunologically activated platelets and endothelial cells in immune complex and vaso- obstructive diseases...
  9. SURGICAL MANAGEMENT OF THE REGIONAL LYMPH NODE
    Bernard Fisher; Fiscal Year: 1980
    ..Macrophages in tumors were identified by the presence of IgG receptors and phagocytosis...
  10. Signaling by IgG receptors leading to phagocytosis
    KENNETH COGGESHALL; Fiscal Year: 2006
    ..that permits genetic analysis of the relationship between signaling molecules utilized by the human-specific IgG receptors. Second, experiments are proposed to understand the signaling mechanism employed by the tailless human-..
  11. BI-SPECIFIC, ANTIBODY-DIRECTED KILLING IN HIV THERAPY
    NATHAN DINCES; Fiscal Year: 1990
    ..In particular, these studies would focus on the ability of monocytes and PMNs targeted through Fc-gamma-RI to mediate killing of cells expressing the gp 120 antigen as a prelude to studies of cytoxity of HIV and HIV infected cells...
  12. Impact of IL-8 Bound to the Anti-IL-8 Autoantibody
    Anna Kurdowska; Fiscal Year: 2007
    ..Our Major Hypothesis is that IgG receptors are the predominant receptors in the lung responsible for initiating the cascade of inflammatory events ..
  13. Daily Low-Dose IL-2 Augments Anti-CD20 Antibody Therapy
    CHARLES EISENBEIS; Fiscal Year: 2005
    ..abstract_text> ..
  14. Systemic Vasculitis: Host Factors in Tissue Injury
    JEFFREY EDBERG; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  15. Genetic Polymorphisms in Wegener's Granulomatosis
    JEFFREY EDBERG; Fiscal Year: 2003
    ....
  16. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2006
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  17. Mechanism of antibody-mediated immunotherapy in AD
    Jeffrey Ravetch; Fiscal Year: 2005
    ....
  18. Neutrophil CD64 Assay for Human Sepsis and Infection
    Bruce Davis; Fiscal Year: 2005
    ..abstract_text> ..
  19. MODULATING AUTOIMMUNE DISEASE BY FC RECEPTORS
    Jeffrey Ravetch; Fiscal Year: 2004
    ..These studies will dissect the novel, FcR-dependent pathways involved in autoimmunity and exploit these observations for the development of innovative therapies. ..
  20. STUDY OF FC RECEPTOR GENES: MACROPHAGES AND LYMPHOCYTES
    Jeffrey Ravetch; Fiscal Year: 2007
    ..unreadable]..
  21. Novel Strategies for Y pestis Immunotherapy
    Jeffrey Ravetch; Fiscal Year: 2003
    ..pestis mutants defective in virulence. This approach will thus permit the evaluation of the interaction of the pathogen with adaptive immune pathways by bypassing the effects on innate responses. ..
  22. FcRn Binds and Transports Albumin
    CLARK ANDERSON; Fiscal Year: 2009
    ..abstract_text> ..
  23. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  24. Nuclear translocation of urokinase/nucleolin complexes
    Douglas Cines; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. DEFENSIN AND THE PATHOGENESIS OF ATHEROSCLEROSIS
    Douglas Cines; Fiscal Year: 2002
    ..Finally, the interaction between endogenous defensin and endogenous Lp(a) will be examined in a novel transgenic mouse than overexpresses both human defensin and human Lp(a). ..
  26. HOW ANTIBODIES WORK--THE FC GAMMA RI MOLECULAR COMPLEX
    CLARK ANDERSON; Fiscal Year: 2001
    ..The experimental approaches of these aims are multidisciplinary and include the methods of immunology, cell biology, molecular genetics, and biochemistry. ..
  27. FcR Enhanced Ag Presentation--Induction Tumor Immunity
    Raphael Clynes; Fiscal Year: 2006
    ..3) Determine whether FcgammaR uptake enhances class I antigen presentation in human systems and specifically whether antibody-mediated T cell priming occurs in Trastuzumab-treated patients. ..
  28. How FcRn Prolongs IgG Lifespan
    CLARK ANDERSON; Fiscal Year: 2005
    ..Our technical approaches to the various aims are broad-based and collaborative and include the methods of cellular and molecular biology, biochemistry, and immunology. ..
  29. Estrogenic LXR Alpha Response /Cholesterol Homeostasis
    Phillip Kramer; Fiscal Year: 2003
    ..abstract_text> ..
  30. STRUCTURE/FUNCTION ANALYSIS OF THE UROKINASE RECEPTOR
    Douglas Cines; Fiscal Year: 2002
    ..abstract_text> ..
  31. Pathogenic Role of Islet Cell Abs in Autoimmune Diabetes
    Raphael A Clynes; Fiscal Year: 2010
    ..We propose in Aim 3 to extend this work to test relevance to the antibody-mediated cross-presentation of insulin, an antigen of singular importance to diabetes. ..
  32. Mechanism of Antibody Therapy in Human B Cell Lymphoma
    Wen Kai Weng; Fiscal Year: 2007
    ..The knowledge generated from this project will help us to design better ways to use monoclonal antibodies and to develop new reagents to treat patients with B cell lymphoma. [unreadable] [unreadable]..
  33. Control of FcgammaR Triggered Macrophage Function
    CLARK ANDERSON; Fiscal Year: 2002
    ..The significance of this work is that understanding these regulatory mechanisms at the molecular level holds the promise of novel therapeutic approaches for modulating antibody- triggered inflammation and killing. ..
  34. Dendritic cell migration in atheroscelrosis
    Gwendalyn Randolph; Fiscal Year: 2004
    ....
  35. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Raphael Clynes; Fiscal Year: 2009
    ....
  36. NOVEL SEROTHERAPY STRATEGIES--PLASMA CELL MALIGNANCIES
    STEVEN TREON; Fiscal Year: 2004
    ..Analogous to our work with Muc-1, we will also attempt to identify other PCD selective targets by generating and examining mAbs specific to the plasma cell glycoform of CD138. ..
  37. Estrogenic Regulation of Inflammation Related to TMJD
    Phillip Kramer; Fiscal Year: 2006
    ..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
  38. Targeting myeloma via dendritic cells
    Madhav Dhodapkar; Fiscal Year: 2009
    ..abstract_text> ..
  39. Predicting HAD using Monocyte Profiling and Neuroimaging
    Lynn Pulliam; Fiscal Year: 2008
    ..These findings will help us develop a monocyte profile for HIV-1-infected individuals at risk for dementia to receive preventive therapy as well as serve as markers to assess effective therapies. [unreadable] [unreadable]..
  40. REGULATION OF PLATELET SHAPE CHANGES
    John Hartwig; Fiscal Year: 2008
    ..abstract_text> ..
  41. CYSTEINE PROTEINASES AS LEISHMANIAL VIRULENCE FACTORS
    LAURENCE BUXBAUM; Fiscal Year: 2002
    ..D. and Ph.D. degrees, with thesis research in the GPI anchor of African trypanosomes. He has completed his clinical training in Internal Medicine and a clinical year of Infectious Diseases at the University of Pennsylvania. ..
  42. Novel strategies for defining the role of HLA in SLE
    Lindsey Criswell; Fiscal Year: 2009
    ..abstract_text> ..
  43. Immune Mechanisms in Heparin-Induced Thrombocytopenia/T*
    Michael Reilly; Fiscal Year: 2004
    ....
  44. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2010
    ..The influx of mathematicians and computer modelers is clearly changing the way we analyze immune behavior. ..
  45. MECHANISM OF AUTOREACTIVITY IN SLE
    Robert Eisenberg; Fiscal Year: 2001
    ..Is the pace of MRL/lpr disease dictated by events that occur after the early lymphocyte stage of ontogeny? 4. Does the genotype of the B cell control the lymphoproliferation of T cells? ..
  46. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  47. PROTECTIVE MECHANISMS WITH ATTENUATED LENTIVIRAL VACCINE
    Christopher Miller; Fiscal Year: 2002
    ....
  48. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2003
    ..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
  49. TESTING SLE CANDIDATE LOCI USING CASES AND THEIR PARENTS
    Lindsey Criswell; Fiscal Year: 2003
    ..Finally, the families recruited for this study will serve as a valuable resource for future genetic epidemiology studies of SLE. Therefore, the efforts of this project represent an important investment for the future. ..
  50. REGULATION OF ACUTE LUNG INJURY BY ACUTE PHASE PROTEINS
    RITA HEUERTZ; Fiscal Year: 2004
    ..The results of this research will also provide valuable support for the potential therapeutic role of CRP in acute, pathological immune reactions, such as ARDS. ..
  51. Developmental Pathobiology of Lymphocyte Fcy Receptors
    Richard Lynch; Fiscal Year: 2003
    ....
  52. Functions of Transmembrane and Soluble Fas ligand
    Ann Marshak Rothstein; Fiscal Year: 2005
    ..These studies will help to assess the feasibility of clinical applications of forced FasL expression and they should further reveal the significance of FasL expression by non-lymphoid tissues. ..
  53. PI3K Signaling in Single Lymphocytes Analyzed by LMS
    David Fruman; Fiscal Year: 2005
    ..Our second aim is to apply this technology to address the role of the PI3K regulatory isoform p85alpha in activation of different downstream signaling molecules. ..
  54. FCGAMMA RECEPTOR IN IMMUNE-COMPLEX MEDIATED INFLAMMATION
    Luminita Pricop; Fiscal Year: 2002
    ....
  55. Phospholipase D and the Actin Cytoskeleton
    DAVID KUSNER; Fiscal Year: 2005
    ..These studies will further both our specific knowledge of signal transduction mechanisms that regulate inflammation as well as our more general understanding of the spatial and temporal determinants of cellular activation and motility. ..
  56. Allergy Therapy with Chimeric Human Ig Proteins
    Andrew Saxon; Fiscal Year: 2007
    ..Further, understanding of the mechanisms underlying the control of activating receptors by inhibitory receptors will have broad reaching implications for the manipulation the immune response. ..
  57. Inhibition of Macrophage Innate Immunity in Tuberculosis
    WILLIAM NAUSEEF; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. REGULATION OF INTESTINAL EPITHELIAL CHEMOKINE SECRETION
    Andrew Gewirtz; Fiscal Year: 2002
    ..In addition to containing an extensive array of basic research equipment, this lab space contains a new thermostatted spectrofluorimeter to be used primarily by Dr. Gewirtz. ..
  59. DEVELOPMENT OF THE PRIMATE IMMUNOLOGY RESOURCE
    Christopher Miller; Fiscal Year: 2003
    ..This type of sustained support for assay development is required if immune studies in non-human primates are going to significantly advance in the near future. ..