cd95 antigens

Summary

Summary: Differentiation antigens expressed on a variety of cell lines including myeloid and lymphoblastoid cell lines. They are members of the tumor necrosis receptor superfamily involved in the regulation of peripheral immune responses and APOPTOSIS.

Top Publications

  1. ncbi Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    H Li
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 94:491-501. 1998
  2. ncbi Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    X Luo
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 94:481-90. 1998
  3. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
  4. ncbi Death receptors: signaling and modulation
    A Ashkenazi
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 281:1305-8. 1998
  5. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  6. ncbi Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
    A Krueger
    Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 276:20633-40. 2001
  7. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
  8. ncbi FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    M R Sprick
    Tumor Immunology Program, German Cancer Research Center DKFZ Heidelberg
    Immunity 12:599-609. 2000
  9. pmc Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    X Yang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:1067-76. 1997
  10. ncbi PML is essential for multiple apoptotic pathways
    Z G Wang
    Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Nat Genet 20:266-72. 1998

Detail Information

Publications340 found, 100 shown here

  1. ncbi Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    H Li
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 94:491-501. 1998
    ..Coexpression of BclxL inhibits all the apoptotic changes induced by tBID. Our results indicate that BID is a mediator of mitochondrial damage induced by Casp8...
  2. ncbi Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    X Luo
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 94:481-90. 1998
    ..The cytochrome c releasing activity of Bid was antagonized by Bcl2. A mutation at the BH3 domain diminished its cytochrome c releasing activity. Bid, therefore, relays an apoptotic signal from the cell surface to mitochondria...
  3. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
  4. ncbi Death receptors: signaling and modulation
    A Ashkenazi
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 281:1305-8. 1998
    ..Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery...
  5. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  6. ncbi Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
    A Krueger
    Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 276:20633-40. 2001
    ..Our results indicate that c-FLIP(L) induces a conformation of procaspase-8 that allows partial but not complete proteolytical processing, whereas in contrast c-FLIP(S) even prevents partial procaspase-8 activation at the DISC...
  7. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
    ..Thus, Fas, TRAIL and TNF receptors can initiate cell death by two alternative pathways, one relying on caspase-8 and the other dependent on the kinase RIP...
  8. ncbi FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    M R Sprick
    Tumor Immunology Program, German Cancer Research Center DKFZ Heidelberg
    Immunity 12:599-609. 2000
    ..FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2...
  9. pmc Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    X Yang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:1067-76. 1997
    ..The Daxx apoptotic pathway is sensitive to both Bcl-2 and dominant-negative JNK pathway components and acts cooperatively with the FADD pathway. Thus, Daxx and FADD define two distinct apoptotic pathways downstream of Fas...
  10. ncbi PML is essential for multiple apoptotic pathways
    Z G Wang
    Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Nat Genet 20:266-72. 1998
    ..These results demonstrate that Pml is a mediator of multiple apoptotic signals, and implicate inhibition of apoptosis in the pathogenesis of APL...
  11. ncbi Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    R Watanabe-Fukunaga
    Osaka Bioscience Institute, Japan
    Nature 356:314-7. 1992
    ..The lpr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus...
  12. ncbi Fas engagement induces neurite growth through ERK activation and p35 upregulation
    Julie Desbarats
    Department of Physiology, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Nat Cell Biol 5:118-25. 2003
    ..Our findings define a role for Fas as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo...
  13. pmc The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
    S A Susin
    Centre National de la Recherche Scientifique UPR420, B P 8, F 94801 Villejuif, France
    J Exp Med 186:25-37. 1997
    ..In addition, they provide a plausible explanation of why Bcl-2 fails to interfere with Fas-triggered apoptosis in most cell types, yet prevents ceramide- and prooxidant-induced apoptosis...
  14. ncbi CD95's deadly mission in the immune system
    P H Krammer
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    Nature 407:789-95. 2000
    ..Gaining an insight into these processes improves our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and opens new approaches to rational treatment strategies...
  15. ncbi Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape
    M Hahne
    Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Science 274:1363-6. 1996
    ..In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors...
  16. pmc c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
    David W Chang
    Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    EMBO J 21:3704-14. 2002
    ..c-FLIP(L) acts as an apoptosis inhibitor only at high ectopic expression levels. Thus, c-FLIP(L) defines a novel type of caspase regulator, distinct from the death adaptors, that can either promote or inhibit apoptosis...
  17. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
    ..Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction...
  18. ncbi Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    T Takahashi
    Osaka Bioscience Institute, Japan
    Cell 76:969-76. 1994
    ..These results indicate that lpr and gld are mutations in Fas and Fasl, respectively, and suggest important roles of the Fas system in development of T cells as well as cytotoxic T lymphocyte-mediated cytotoxicity...
  19. ncbi Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
    J Cheng
    University of Alabama at Birmingham
    Science 263:1759-62. 1994
    ..Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features...
  20. ncbi The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
    C Gajate
    , , CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Blood 98:3860-3. 2001
    ..This translocation of Fas into membrane rafts may provide a mechanism for amplifying Fas signaling by reorganization of membrane microdomains...
  21. ncbi Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire
    Y Takahashi
    Department of Immunology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, 162 8640, Tokyo, Japan
    Immunity 14:181-92. 2001
    ..These results suggest that Fas is required for clonal selection within GCs and the establishment of the memory B cell repertoire...
  22. ncbi Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival
    Michelle A Hughes
    University of Leicester, UK
    Mol Cell 35:265-79. 2009
    ..Thus, using the reconstituted DISC, we have delineated a crucial two-step activation mechanism whereby activated death receptor complexes can trigger death or survival...
  23. ncbi The role of c-FLIP in modulation of CD95-induced apoptosis
    C Scaffidi
    Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 274:1541-8. 1999
    ..Moreover, recruitment of FADD, caspase-8, and c-FLIP to the DISC was strongly reduced in the apoptosis-resistant but readily detectable in the apoptosis-sensitive T cells...
  24. ncbi Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors
    Matti Ahonen
    Centre for Biotechonology, University of Turku, Finland
    Oncogene 22:2121-34. 2003
    ..Taken together, these results show that TIMP-3 promotes apoptosis in melanoma cells through stabilization of three distinct death receptors and activation of their apoptotic signaling cascade through caspase-8...
  25. ncbi Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis
    Fredoen Valianpour
    Laboratory of Genetic Metabolic Diseases, Department of Clinical Chemistry, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Lipid Res 46:1182-95. 2005
    ....
  26. ncbi A novel receptor for Apo2L/TRAIL contains a truncated death domain
    S A Marsters
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080 4918, USA
    Curr Biol 7:1003-6. 1997
    ..Upon overexpression, DcR2 did not activate apoptosis or nuclear factor-kappaB; however, it substantially reduced cellular sensitivity to Apo2L-induced apoptosis. These results suggest that DcR2 functions as an inhibitory Apo2L receptor...
  27. pmc Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
    S M Srinivasula
    Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 93:14486-91. 1996
    ..On the other hand, Mch4 could be a second upstream protease that is responsible for activation of the same protease cascade in CrmA-insensitive apoptotic pathways...
  28. ncbi Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition
    Marco Tafani
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10073-82. 2002
    ..It is concluded that the cleaving of PARP in Fas-mediated apoptosis allowed expression of an energy-dependent cell death program that included the translocation of full-length Bid to the mitochondria with induction of the MPT...
  29. ncbi Death receptor-induced cell killing
    Andrew Thorburn
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cell Signal 16:139-44. 2004
    ..However, recent studies indicate that we must incorporate new information into this model. Some examples that add new layers of complexity will be discussed in this review...
  30. ncbi The CD95 type I/type II model
    Bryan C Barnhart
    The Ben May Institutefor Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Semin Immunol 15:185-93. 2003
    ..This review focuses on recent developments in the delineation of the biochemistry and the physiological function of the two CD95 pathways...
  31. pmc Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
    ..These data raise the possibility that Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis...
  32. pmc Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells
    Hubert Arokium
    Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, David Geffen School of Medicine, 615 Charles E Young Dr South, BSRB 173, Los Angeles, CA 90095, USA
    J Virol 83:11283-97. 2009
    ..These findings suggest that virion-associated Vpr can contribute to the depletion of CD4(+) lymphocytes either directly or by enhancing Fas-mediated apoptosis during acute HIV-1 infection and in AIDS...
  33. pmc Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
    ..Therefore, Fas and FasL are negative regulators of erythropoiesis. Epo-mediated suppression of erythroblast Fas and FasL is a novel stress response pathway that facilitates erythroblast expansion in vivo...
  34. ncbi Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
    Consuelo Gajate
    Unidad de Investigacion, Hospital Universitario de Salamanca, Spain
    Blood 109:711-9. 2007
    ..These data uncover a novel lipid raft-mediated therapy in MM involving concentration of death receptors in membrane rafts, with Fas/CD95 playing a major role in ALP-mediated apoptosis...
  35. pmc Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions
    E A Reap
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7280, USA
    Proc Natl Acad Sci U S A 94:5750-5. 1997
    ..Fas/FasL interactions may thus play an important role in identifying and eliminating damaged cells after gamma-irradiation and other forms of injury...
  36. ncbi The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia
    S A Boehme
    Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
    J Immunol 165:397-403. 2000
    ..These results, therefore, suggest that the interaction between fractalkine and CX3CR-1 may play an important role in promoting and preserving microglial cell survival in the CNS...
  37. ncbi Ceramide-mediated clustering is required for CD95-DISC formation
    Heike Grassme
    Department of Molecular Biology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Oncogene 22:5457-70. 2003
    ....
  38. pmc Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    Susan A Krum
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    EMBO J 27:535-45. 2008
    ..These results demonstrate that estrogen protects bone by inducing a paracrine signal originating in osteoblasts leading to the death of pre-osteoclasts and offer an important new target for the prevention and treatment of osteoporosis...
  39. ncbi Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 98:47-58. 1999
    ..These results provide evidence that inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II...
  40. ncbi Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma
    G Dworacki
    Department of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pennsylvania 15213-2582, USA
    Clin Cancer Res 7:947s-957s. 2001
    ..In the circulation of patients with melanoma, apoptosis of immune effector cells may be related to the state of chronic activation, resulting in the up-regulation of death receptors and increased susceptibility to apoptosis...
  41. ncbi Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
    P Juo
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 8:1001-8. 1998
    ..The intracellular domain of Fas interacts with several proteins including FADD (MORT-1), DAXX, RIP, FAF-1, FAP-1 and Sentrin. The adaptor protein FADD can, in turn, interact with the cysteine protease caspase-8 (FLICE/MACH/Mch5)...
  42. ncbi Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations
    Cedric Raoul
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Neuron 35:1067-83. 2002
    ..Thus, triggering of a motoneuron-restricted cell death pathway by neighboring cells might contribute to motoneuron loss in ALS...
  43. ncbi Non-apoptotic Fas signaling
    Harald Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Germany
    Cytokine Growth Factor Rev 14:53-66. 2003
    ..This review is focused on the non-apoptotic functions of the FasL/Fas system. In particular, the similarities and differences of the molecular mechanisms of apoptotic and non-apoptotic Fas signaling are addressed...
  44. ncbi Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase
    C Scaffidi
    Tumor Immunology Program, Applied Tumorvirology, German Cancer Research Center, Heidelberg, Germany
    J Immunol 164:1236-42. 2000
    ..Because CD95-mediated apoptosis is independent of the cell cycle, phosphorylation of FADD may regulate its apoptosis-independent functions...
  45. pmc Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
    W S Chen
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 15:2203-8. 2001
    ..Finally, Akt1(-/-) mouse embryo fibroblasts (MEFs) are more susceptible to apoptosis induced by TNF, anti-Fas, UV irradiation, and serum withdrawal...
  46. ncbi Inflammatory cytokines and lipopolysaccharide induce Fas-mediated apoptosis in renal tubular cells
    Sang Kyung Jo
    Department of Internal Medicine, Korea University Hospital, Anam dong 5Ka, 136 705 Sungbuk ku, Seoul, Korea
    Nephron 91:406-15. 2002
    ....
  47. pmc FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies
    Kristijana Milovic-Holm
    Heinrich Pette Institut für Experimentelle Virologie und Immunologie, Hamburg, Germany
    EMBO J 26:391-401. 2007
    ..In summary, our findings suggest that CD95 signals via a previously unrecognized nuclear pathway mediated by nucleo-cytoplasmic translocation of FLASH...
  48. ncbi Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
    M O Westendorp
    Tumorimmunology Program, German Cancer Research Centre, Heidelberg
    Nature 375:497-500. 1995
    ..Taken together, our results indicate that HIV-1 Tat and gp120 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+ T-cell depletion in AIDS...
  49. ncbi Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
    Stefan Schütze
    Institute of Immunology, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Nat Rev Mol Cell Biol 9:655-62. 2008
    ..Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell...
  50. ncbi Expression of Fas and Fas-related molecules in human hepatocellular carcinoma
    S H Lee
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Hum Pathol 32:250-6. 2001
    ..hum pathol 32:250-256...
  51. ncbi The Fas signaling pathway: more than a paradigm
    Harald Wajant
    Institute of Cell Biology and Immunology, Allmandring 31, University of Stuttgart, 70 569 Stuttgart, Germany
    Science 296:1635-6. 2002
    ....
  52. ncbi Caspase-independent cell death in T lymphocytes
    Marja Jaattela
    Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Immunol 4:416-23. 2003
    ....
  53. ncbi Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity
    N Mitsiades
    Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston 02129, USA
    Cancer Res 61:577-81. 2001
    ..Our observations provide evidence that one mechanism whereby MMP-7 may promote tumor survival and resistance to doxorubicin is by cleaving FasL and reducing its effectiveness in triggering Fas-mediated apoptosis...
  54. ncbi Impaired Fas response and autoimmunity in Pten+/- mice
    A Di Cristofano
    Department of Human Genetics Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 285:2122-5. 1999
    ..These results indicate that Pten is an essential mediator of the Fas response and a repressor of autoimmunity and thus implicate the PI 3-kinase/Akt pathway in Fas-mediated apoptosis...
  55. pmc Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice
    S Vidal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 101:696-702. 1998
    ..The identification of loci with highly significant linkage to disease manifestations in Faslpr strains will make it possible to map and clone new genetic defects contributing to autoimmunity...
  56. pmc Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis
    F Aoudjit
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Cell Biol 152:633-43. 2001
    ..These studies identify matrix attachment as a survival factor against death receptor-mediated apoptosis and provide a molecular mechanism for anoikis and previously observed Fas resistance in endothelial cells...
  57. pmc T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
    Zhenyue Hao
    620 University Ave, Toronto, ON, M5G 2C1, Canada
    J Exp Med 199:1355-65. 2004
    ....
  58. pmc Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    F C Kischkel
    Tumor Immunology Program, German Cancer Center, Heidelberg, Germany
    EMBO J 14:5579-88. 1995
    ..Moreover, no APO-1-CAP association was found in the APO-1+, anti-APO-1-resistant pre-B cell line Boe. Our data suggest that in vivo CAP1-4 are the APO-1 apoptosis-transducing molecules...
  59. ncbi The role of CD95 in the regulation of peripheral T-cell apoptosis
    Andreas Krueger
    Tumorimmunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Immunol Rev 193:58-69. 2003
    ..We discuss how these costimulatory signals counteract pro-apoptotic signals and, finally, which signals might protect T cells from death to generate a pool of memory T cells...
  60. ncbi Fas-mediated apoptosis in primary cultured mouse hepatocytes
    R Ni
    School of Medicine, University of Tokushima, Japan
    Exp Cell Res 215:332-7. 1994
    ....
  61. ncbi Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid
    Brigitte M T Hougardy
    Department of Gynecology Oncology, University Medical Center Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Gynecol Oncol 97:353-64. 2005
    ..In the present study, the functionality of the Fas pathway was studied in human cervical cancer cells with different HPV and p53 status...
  62. ncbi Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells
    Dominique Delmas
    INSERM U517, IFR100 Faculty of Medicine, 7 Boulevard Jeanne d Arc, 21000 Dijon, France
    J Biol Chem 278:41482-90. 2003
    ..Altogether, these results indicate that the ability of resveratrol to induce the redistribution of Fas receptor in membrane rafts may contribute to the molecule's ability to trigger apoptosis in colon cancer cells...
  63. ncbi IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
    M X Wu
    Division of Tumor Immunology, Dana Farber Cancer Institute, and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Science 281:998-1001. 1998
    ..In support, overexpression of antisense IEX-1L partially blocked TNF-induced expression of IEX-1L and sensitized normal cells to killing. This study demonstrates a key role of IEX-1L in cellular resistance to TNF-induced apoptosis...
  64. ncbi Neural stem cells and cell death
    S Ceccatelli
    Division of Toxicology and Neurotoxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm S 171 77, Sweden
    Toxicol Lett 149:59-66. 2004
    ..The Fas-induced ERK phosphorylation that we detect in C17.2 cells suggests that in NSC Fas may function as a mediator of growth rather than death...
  65. pmc BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
    H Zhang
    Program on Apoptosis and Cell Death Regulation, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:2597-602. 2000
    ..The BAR protein is anchored in intracellular membranes where Bcl-2 resides. BAR therefore may represent a scaffold protein capable of bridging two major apoptosis pathways...
  66. ncbi Fas and Fas ligand: lpr and gld mutations
    S Nagata
    Osaka Bioscience Institute, Japan
    Immunol Today 16:39-43. 1995
    ..Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and FasL, and discuss the physiological role of the Fas system in T-cell development, cytotoxicity and cytotoxic T lymphocyte (CTL)-mediated autoimmune disease...
  67. ncbi Fas-beyond death: a regenerative role for Fas in the nervous system
    C Lambert
    Department of Physiology, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Apoptosis 8:551-62. 2003
    ..Here, we review the literature on non-apoptotic Fas signalling pathways, and discuss the potential roles, molecular mechanisms, and regulators of Fas signalling in the nervous system...
  68. pmc Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
    M Bentele
    Division Theoretical Bioinformatics, German Caner Research Center DKFZ, Heidelberg 69120, Germany
    J Cell Biol 166:839-51. 2004
    ..Our model describes the regulation of apoptosis on a systems level and resolves the important question of a threshold mechanism for the regulation of apoptosis...
  69. ncbi Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
    R M Pitti
    Department of Molecular Oncology, Molecular Biology, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 396:699-703. 1998
    ..Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL...
  70. pmc The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo
    Megan S Ford
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 196:261-7. 2002
    ..These findings clearly demonstrate that B6/lpr DNTC have a potent immune regulatory function in vitro and in vivo. They also provide new insights into the mechanisms involved in the development of autoimmune disease in lpr mice...
  71. ncbi Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Shawn Hayley
    Ottawa Health Research Institute, Neuroscience Group, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 24:2045-53. 2004
    ..Despite the reduced terminals, dopamine levels were not further suppressed by MPTP treatment in mutant mice, raising the possibility of a compensatory response in basal ganglia function in Fas-deficient mice...
  72. ncbi Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    B Lowin
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nature 370:650-2. 1994
    ..Thus, two complementary, specific cytotoxic mechanisms are functional in CTLs, one based on the secretion of lytic proteins and one which depends on cell-surface ligand-receptor interaction...
  73. ncbi Death receptors in chemotherapy and cancer
    Klaus Michael Debatin
    University Children s Hospital, Prittwitzstr 43, Ulm 89075, Germany
    Oncogene 23:2950-66. 2004
    ..Understanding the molecular events that regulate apoptosis induced by anticancer therapy and how cancer cells evade apoptosis may provide new opportunities for pathway-based rational therapy and for drug development...
  74. pmc Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords
    Alison J Johnson
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0436, USA
    J Virol 82:9678-88. 2008
    ....
  75. ncbi Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    Z X Zhang
    Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
    Nat Med 6:782-9. 2000
    ..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
  76. pmc Prognostic impact of FAS/CD95/APO-1 in urothelial cancers: decreased expression of Fas is associated with disease progression
    K Yamana
    Division of Molecular Oncology, Department of Signal Transduction Research, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Br J Cancer 93:544-51. 2005
    ..Moreover, low-dose anti-Fas-activating mAb sensitised resistant cells to adriamycin, and this synergistic effect could be applied in the development of new treatment strategy for UC patients with multidrug-resistant tumours...
  77. ncbi Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
    Delphine Milhas
    INSERM U466, Institut Louis Bugnard, Toulouse, France
    J Biol Chem 280:19836-42. 2005
    ..Altogether, our data strongly suggest that caspase-10 can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis...
  78. pmc Dynamics within the CD95 death-inducing signaling complex decide life and death of cells
    Leo Neumann
    Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Syst Biol 6:352. 2010
    ..We present an integrated model describing the complex dynamics of CD95-mediated apoptosis and NF-kappaB signaling...
  79. pmc Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice
    M Adachi
    Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 90:1756-60. 1993
    ..These findings suggest that lpr mice are able to express a very low level of the Fas antigen...
  80. ncbi Toll-like receptors and activation of autoreactive B cells
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Mass, USA
    Curr Dir Autoimmun 6:105-22. 2003
  81. ncbi Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis 55455, USA
    Nature 434:1148-52. 2005
    ..The scale of this CD4+ T-cell depletion has adverse effects on the immune system of the host, underscoring the importance of developing countermeasures to SIV that are effective before infection of GALT...
  82. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..These results identify critical overlapping roles for Fas and Bim in T cell death in immune response shutdown and prevention of immunopathology and thereby resolve a long-standing controversy...
  83. pmc CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival
    P M Stuart
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 99:396-402. 1997
    ..Taken together our results demonstrate that FasL expression on the cornea is a major factor in corneal allograft survival and, thus, we provide an explanation for one of the most successful tissue transplants performed in humans...
  84. pmc Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
    Martin R Sprick
    Division for Apoptosis Regulation, Tumour Immunology Program, DKFZ, Heidelberg, Germany
    EMBO J 21:4520-30. 2002
    ..Finally, we demonstrate that caspase-10 is cleaved during CD95-induced apoptosis of activated T cells. These results show that caspase-10 activation occurs in primary cells, but that its function differs from that of caspase-8...
  85. ncbi A role for CD95 ligand in preventing graft rejection
    D Bellgrau
    Department of Immunology, University of Colorado School of Medicine, Denver 80262, USA
    Nature 377:630-2. 1995
    ..These findings indicate that CD95 ligand could be used to create immune-privileged tissue for a variety of transplant uses...
  86. ncbi Fas and Fas-L expression in Huntington's disease and Parkinson's disease
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Barcelona, Spain
    Neuropathol Appl Neurobiol 26:424-33. 2000
    ..The meaning of increased Fas and Fas-L expression in astrocytes is still unclear. However, the present results suggest that Fas/Fas-L signals are minimized in sensitive neurones in HD and PD...
  87. ncbi Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase
    Claudio A Hetz
    Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Sci 115:4671-83. 2002
    ..Thus, delayed elevation of ceramide is proposed to promote necrosis in those Fas-stimulated cells where caspase-8 activation was insufficient to trigger caspase-3-dependent apoptosis...
  88. ncbi Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
    M J Parsons
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    J Immunol 167:42-8. 2001
    ..Therefore, T cell expression of active protein kinase B can alter T cell homeostasis, indirectly influence B cell homeostasis, and promote inflammation in vivo...
  89. ncbi CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells
    Adriana Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 34:1930-40. 2004
    ..Taken together, our data demonstrate that CD95 death-inducing signaling complex formation and internalization in type I and type II cells occur in lipid rafts, which are a major site of caspase-8 activation...
  90. ncbi Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis
    B N Dittel
    Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT 06520, USA
    J Immunol 162:6392-400. 1999
    ..Furthermore, transfer of cells lacking FasL (gld) into normal or gld recipients gave a diminished disease score. Thus, Fas/FasL interactions can play a role in the pathogenesis of EAE, but they are not required for disease to occur...
  91. pmc Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene
    J Wu
    University of Alabama, Birmingham
    J Exp Med 178:461-8. 1993
    ..These results establish a link between endogenous retrovirus expression, abnormal Fas expression, and autoimmune disease...
  92. ncbi Fas engagement accelerates liver regeneration after partial hepatectomy
    J Desbarats
    Department of Medicine, University of Vermont, Burlington, Vermont 05401, USA
    Nat Med 6:920-3. 2000
    ..Our results indicate that Fas engagement on cells in regenerating or healing tissues may promote cell growth...
  93. ncbi The CD95 receptor: apoptosis revisited
    Marcus E Peter
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Cell 129:447-50. 2007
    ..Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions...
  94. pmc FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
    K G Smith
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 92:11628-32. 1995
    ..The results suggest that the size and composition of B-cell compartments in the humoral immune response are regulated by mechanisms that do not require FAS...
  95. ncbi Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis
    J P Medema
    Tumorimmunology Program, German Cancer Research Center, Heidelberg
    Eur J Immunol 27:3492-8. 1997
    ..We therefore conclude that FLICE not only plays a central role in CD95(APO-1/Fas)-induced apoptosis but can also be directly activated during perforin/GrB-induced apoptosis...
  96. pmc Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death
    K Schulze-Osthoff
    Division of Immunochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    EMBO J 13:4587-96. 1994
    ..Hence, cells may undergo different programs of cell death depending on the activating stimulus...
  97. pmc Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome
    J L Chu
    Specialized Center of Research in Systemic Lupus Erythematosus, Hospital for Special Surgery Cornell University Medical Center, New York 10021
    J Exp Med 181:393-8. 1995
    ..This phenomenon could explain the lpr-induced wasting syndrome observed when lpr bone marrow-derived cells are adoptively transferred to wild-type recipients...
  98. ncbi Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    Jeong Whun Kim
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Clin Cancer Res 11:1010-20. 2005
    ..The present study was done to identify mechanisms responsible for apoptosis of T cells seen in the peripheral circulation of these patients...
  99. ncbi Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling
    Inna N Lavrik
    Division of Immunogenetics, Tumorimmunology Program, Im Neuenheimer Feld, Heidelberg, Germany
    J Biol Chem 282:13664-71. 2007
    ..Interestingly, we found that mitogen-activated protein kinase activation takes place under threshold conditions. These findings show that triggering of CD95 can signal both life or death, depending on the strength of the stimulus...
  100. pmc In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
    S V Pakala
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 189:1053-62. 1999
    ..These results argue that islet cells play a TNF-alpha-dependent role in their own demise...
  101. pmc Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    J P Medema
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Exp Med 190:1033-8. 1999
    ....

Research Grants65

  1. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ....
  2. Autophagy and control of photoreceptor apoptosis
    David N Zacks; Fiscal Year: 2013
    ....
  3. Role of Stress-Response Protein gp96 in the Persistence of Rheumatoid Arthritis
    Richard M Pope; Fiscal Year: 2012
    ..The work proposed in this study is aimed at identifying novel mechanisms contributing to the pathogenesis of rheumatoid arthritis, which would define new therapeutic targets. ..
  4. Protection of vaccine immunity by inhibiting Fas/FasL signaling
    Maria S Salvato; Fiscal Year: 2010
    ..Our studies propose to test inhibitors of cell-death signals that would have short-term effects and highly-specific targets, yet would not interfere with the development of strong responses against cancers or infections. ..
  5. Prevention of photoreceptor cell death with intravitreal Fas-receptor antagonist
    Jeffrey A Jamison; Fiscal Year: 2012
    ....
  6. RIPK1: A new target for traumatic brain injury?
    Michael J Whalen; Fiscal Year: 2013
    ..The proposed drug therapy might reduce brain cell death as well as improve learning and memory in survivors, and thereby improve their quality of life. ..
  7. Role of MMP-9 in selective motor neuron degeneration in ALS
    Christopher Henderson; Fiscal Year: 2013
    ..Overall, the results should provide novel insights into the mechanisms of motor neuron degeneration in ALS and important preclinical indications as to the potential of MMP-9 as a therapeutic target for future development. ..
  8. Rho GTPases and Neuroprotection Model in Cancer Therapy
    Qun Lu; Fiscal Year: 2012
    ..This project is a preclinical study to determine whether suppression of Rho GTPase signaling coupled with chemotherapy drugs provides an effective strategy for attacking cancer while protecting neurons. ..
  9. Plasmalemma permeability and necroptosis: New targets for intracerebral hemo
    Michael J Whalen; Fiscal Year: 2013
    ..Completion of these Aims will establish necrosis as central to ICH, and may establish VA64 and necrostatins as novel therapies for ICH. ..
  10. Mechanisms of apoptotic calcium signaling
    DARREN F BOEHNING; Fiscal Year: 2013
    ..These studies may uncover novel therapeutic targets for diseases associated with altered T cell homeostasis. ..
  11. Cancer Cell Overexpression of Death Receptor Modulator
    Felipe Samaniego; Fiscal Year: 2013
    ..The long-term goal of this project is to develop targeted therapies to directly promote cancer cell apoptosis and greatly enhance current cancer therapies. ..
  12. HEPATITIS C IN CLINICALLY DISCORDANT HEMOPHILIC SIBLINGS
    Michael Fried; Fiscal Year: 2002
    ..abstract_text> ..
  13. EOSINOPHIL APOPTOSIS IN ASTHMA
    Gerald Litwack; Fiscal Year: 2001
    ..Furthermore, manipulation of these pathways will be a key area for therapeutic intervention in asthma. ..
  14. FAS ANTIGEN AND OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2000
    ..This laboratory has the facilities and expertise in ovarian physiology and molecular biology to undertake these studies. ..
  15. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2009
    ..By defining the role for immune cell destruction in vaccine evasion, we contribute to a complete understanding of potential mechanisms for vaccine failure that will be used to improve the design and testing of candidate HIV vaccines. ..
  16. APOPTOSIS IN HEPATOCYTES
    Harriet Isom; Fiscal Year: 2001
    ..3) To determine how DMSO removal sensitizes hepatocytes to TNFalpha/Fas- induced apoptosis. ..
  17. MOLECULAR MECHANISMS OF BONE MARROW INDUCED TOLERANCE
    James George; Fiscal Year: 2003
    ..The information generated will provide information regarding the specific cellular and subcellular events that are critical to the induction and maintenance of tolerance in this system. ..
  18. Mechanism of activation of the JNK pathway by bile acids
    Seema Gupta; Fiscal Year: 2006
    ....
  19. DYSREGULATION OF APOPTOSIS IN LGL LEUKEMIA
    Thomas Loughran; Fiscal Year: 2000
    ..Results of these studies may suggest that novel strategies targeting Fas ligand would be efficacious for treatment of malignancies and autoimmune diseases. ..
  20. Inhibition of CTL killing by HSV
    KEITH JEROME; Fiscal Year: 2005
    ....
  21. NOVEL FAS BINDING PROTEIN AND ITS ROLE IN DISEASE
    Raif Geha; Fiscal Year: 1999
    ..The proposed studies may lead to a better understanding of the mechanisms of apoptosis and self tolerance and to novel strategies for the treatment of autoimmune diseases. ..
  22. REGULATED APOPTOSIS IN THE TREATMENT OF PROSTATE CANCER
    David Spencer; Fiscal Year: 2001
    ..In addition to their potential use as anti-neoplastic agents, these "death switches" should also have broad applications for developmental studies for increasing the safety of gene therapy vectors. ..
  23. Pharmacodynamic Thresholds of Immunosuppression
    Rakesh Sindhi; Fiscal Year: 2004
    ..Potential benefits may include customized regimens in the future, and decreased complications in one-half of the nearly 40,000 new transplant recipients of solid organ and bone marrow grafts, each year. ..
  24. SYNERGISTIC CHEMO RADIOIMMUNOTHERAPY FOR B LYMPHOMAS
    Timothy Johnson; Fiscal Year: 2003
    ..abstract_text> ..
  25. Autoimmune Mechanisms of Diabetic Neuropathy
    John W Wiley; Fiscal Year: 2010
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. . ..
  26. REGULATION OF EOSINOPHIL SURVIVAL
    Anne Sperling; Fiscal Year: 2004
    ..2) The role of T cells the Fas-induced apoptosis in vitro and in vivo will be determined. (3) The role of different T cell subsets and T cell cytokines the survival of death of eosinophils will be determined. ..
  27. MECHANISMS OF PROGRAMED CELL DEATH IN EOSINOPHILS
    James Zangrilli; Fiscal Year: 2002
    ..End of Abstract) ..
  28. FUNCTION OF THE ADENOVIRUS E1B ONCOGENE
    Eileen White; Fiscal Year: 2000
    ..Defining the process of apoptosis at the molecular level is of basic importance to understanding development, cancer, degenerative diseases, and viral pathogenesis. ..
  29. INTERACTION OF PROTEINS WITH AD INHIBITOR OF TNF-ALPHA
    Marshall Horwitz; Fiscal Year: 2001
    ..What we learn from studying viral genes that have evolved to prevent cell death by interacting with novel cellular targets should extend our understanding about a variety of human diseases affected by this basic process. ..
  30. Using VEGF expression in inflammatory arthritis to induce targeted apoptosis
    Mary Nakamura; Fiscal Year: 2009
    ..Our studies will further our understanding of disease pathogenesis in inflammatory arthritis and examine a novel type of therapeutic in animal models for this disease. ..
  31. HIV ENVELOPE GLYCOPROTEINS AND IMMUNITY
    Savita Pahwa; Fiscal Year: 2000
    ..Attempts will be made to reverse or prevent CD4XL-induced harmful effects. These findings have relevance for understanding AIDS pathogenesis and for designing immune based therapeutic strategies and vaccines. ..
  32. CLINICAL INVESTIGATIONS IN LGL LEUKEMIA
    Thomas Loughran; Fiscal Year: 2004
    ..The work proposed is important not only for further understanding the pathogenesis of malignancies and autoimmune diseases, but also for providing training for clinical investigators in hematologic malignancies. ..
  33. OCULAR IMMUNOPATHOLOGY IN AUTOIMMUNE MODELS
    DOUGLAS JABS; Fiscal Year: 2001
    ....
  34. Initiation of Cell Death after Traumatic Brain Injury
    Michael Whalen; Fiscal Year: 2009
    ..The goal of this revised proposal is to conclusively demonstrate that redundant and opposing effects of multiple TNFR family members integrate to significantly influence cell death, as well as motor and cognitive outcome, after TBI. ..
  35. FAS ANTIGEN AND PERIPHERAL T CELL TOLERANCE
    Casey Weaver; Fiscal Year: 1999
    ....
  36. "Enhancement of Brain Tumor Immunotherapy by Fas-L RNAi"
    Alessandro Olivi; Fiscal Year: 2009
    ..The potential benefit of Fas-L RNAi delivered in this fashion could be applicable to several malignancies that have the Fas/Fas-L pathway among their immune privilege strategies. ..
  37. EFFECTS OF ALCOHOL RECOGNITION OF NEURAL STEM CELLS
    W Zawada; Fiscal Year: 2006
    ..Such findings will stimulate further research bridging fields of alcohol, stem cells and immunology. ..
  38. TUMOR NECROSIS FACTOR FAMILY MECHANISM OF ACTION
    Moses Chao; Fiscal Year: 2003
    ..These studies will provide insight into mechanisms responsible for cytokine actions during inflammation, injury and disease states. ..
  39. Fas Internalization and Beta Cells
    Marcus Peter; Fiscal Year: 2003
    ..The results of this pilot study could lead to a novel concept in tolerizing transplants and treating autoimmune diseases. ..
  40. "Enhancement of Brain Tumor Immunotherapy by Fas-L RNAi"
    Alessandro Olivi; Fiscal Year: 2006
    ..The potential benefit of Fas-L RNAi delivered in this fashion could be applicable to several malignancies that have the Fas/Fas-L pathway among their immune privilege strategies. ..
  41. FAS-MEDIATED APOPTOSIS IN HEMATOLOGIC MALIGNANCIES
    ELAINE SCHATTNER; Fiscal Year: 2000
    ..To examine how CD40L-induced Fas expression and apoptosis in malignant B cells can be applied in vivo, using adoptive transfer of human tumor cells into SCID (severe combined immunodeficiency) mice. ..
  42. MOLECULAR MEDIATORS OF RADIATION-INDUCED APOPTOSIS
    Alnawaz Rehemtulla; Fiscal Year: 2000
    ..The subsequent role in activation of FLICE will be tested followed by investigation of the role of ICE-like proteases in UV-induced apoptosis. These studies will provide a detailed picture of the pathway for UV-induced apoptosis. ..
  43. Neural Stem Cells to Induce Apoptosis in Glial Tumors
    Kadir Erkmen; Fiscal Year: 2001
    ..The unique migratory behavior of NSC's in juxtaposition to tumor cells will allow delivery of FasL to infiltrating glial cells, potentially overcoming previous obstacles to the treatment of these tumors. ..
  44. Pseudomonas aeruginosa-induced host cell pathogenesis
    Sasha Shafikhani; Fiscal Year: 2005
    ..We will express the PA TTSS in a Yersinia strain that lacks the plasmid encoded TTSS and test for restoration of apoptosis-inducing activity. ..
  45. Alcohol Abuse, CD4+ T-cell Depletion & HIV Pathogenesis
    Shirish Barve; Fiscal Year: 2002
    ....
  46. A NOVEL APOPTOSIS ASSAY WITH ANTIBODIES TO SSDNA
    OSKAR FRANKFURT; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATION: To market apoptosis assay. ..
  47. IMMUNE ACCEPTANCE OF PREGNANCY
    Gil Mor; Fiscal Year: 2002
    ..The significance of this proposal is not limited to reproductive problems. It is anticipated that these studies will lead to a better understanding of tumor behavior, actions of chemotherapeutic agents and transplant physiology. ..
  48. Meeting of American Society for Reproductive Immunology:
    Gil Mor; Fiscal Year: 2003
    ..abstract_text> ..
  49. ROLE OF THE FAS ANTIGEN IN OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2004
    ..Understanding pathways that promote or prevent susceptibility of ovarian cells to apoptosis may lead to development of novel therapies for ovarian and other cancers. ..
  50. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2004
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..
  51. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2003
    ..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
  52. Depletion of Mitochondrial S-Nitrosothiols in ALS
    Joan Mannick; Fiscal Year: 2005
    ..Our long term goal is to determine if SNO donor compounds (which have been used for decades in the treatment of coronary artery disease with limited toxicity) have therapeutic efficacy in patients with ALS. ..
  53. "The alveolar epithelium in lung injury and repair"
    Gustavo Matute Bello; Fiscal Year: 2010
    ..In addition, we will investigate the potential treatments that will facilitate the repair of injured lungs. ..
  54. Nitrosylation of Cytochrome C during Apoptosis
    Joan Mannick; Fiscal Year: 2007
    ..Ultimately the findings may lead to the development of rational NO-based therapies for diseases associated with dysregulated apoptosis including cancer, autoimmune disease and neurodegeneration. [unreadable] [unreadable]..
  55. The FastFasL system in lung injury
    Gustavo Matute Bello; Fiscal Year: 2006
    ..The proposed studies will allow for the acquisition of new techniques and further scientific development of the trainee into an independent investigator. ..
  56. B220+ DN alphabeta T cell as a novel immunoregulatory T*
    ABDEL HAMAD; Fiscal Year: 2005
    ..The findings generated by these studies will aid in characterizing a novel naturally occurring regulatory T cells and define their role in peripheral and mucosal tolerance. ..
  57. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005
    ..In addition, they lay the groundwork for the analysis of B220+ DN T cell in healthy individuals and IBD patients. ..
  58. Cisplatin and Mechanisms of Long-term Male Infertility
    JOHN RICHBURG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    JOHN RICHBURG; Fiscal Year: 2006
    ....
  60. ENVIRONMENTAL TESTICULAR TOXICITY & GERM CELL APOPTOSIS
    JOHN RICHBURG; Fiscal Year: 2004
    ..This investigation of MEHP-stimulated germ cell apoptosis will provide fundamental insights into mechanisms regulating the sensitivity of germ cell to undergo apoptosis after chemical-induced testicular injury. ..
  61. Death Receptor Signaling and Mercury Immunotoxicity
    Michael McCabe; Fiscal Year: 2006
    ..A third specific aim will employ a mouse model to test whether disruption of CD95-mediated cell death by Hg intoxication in vivo enhances the survival of autoreactive T lymphocytes. ..
  62. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..Finally, studies in Aim 5 will evaluate clinical specimens from patients AMD for Fas/FasL expression. Our studies should provide important insights into one of the leading causes of blindness in the western world. ..
  63. Enhancement of Dendritic Cells for Improved Immunotherapy
    David Spencer; Fiscal Year: 2009
    ..These three aims should ultimately lead to improved clinical applications of DCs for not only treating malignancy but numerous pathogens, as well. ..