cd8 antigens

Summary

Summary: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.

Top Publications

  1. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
  2. ncbi Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
    K M Murphy
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 250:1720-3. 1990
  3. ncbi Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    H Hochrein
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 166:5448-55. 2001
  4. ncbi Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells
    J L Pooley
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 166:5327-30. 2001
  5. pmc Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    PLoS Pathog 3:1240-9. 2007
  6. ncbi Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
  7. ncbi The CD8alpha gene locus is regulated by the Ikaros family of proteins
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, NW7 1AA, London, United Kingdom
    Mol Cell 10:1403-15. 2002
  8. ncbi Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
    D I Godfrey
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 152:4783-92. 1994
  9. pmc The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    E K Barber
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:3277-81. 1989
  10. pmc Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
    R Bosselut
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 190:1517-26. 1999

Detail Information

Publications244 found, 100 shown here

  1. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  2. ncbi Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
    K M Murphy
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 250:1720-3. 1990
    ..Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance...
  3. ncbi Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    H Hochrein
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 166:5448-55. 2001
    ..In contrast, the CD4(-)8(-) DC produced much more IFN-gamma than the CD4(-)8(+) or the CD4(+)8(-) DC under all conditions tested...
  4. ncbi Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells
    J L Pooley
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 166:5327-30. 2001
    ..This differential persisted when the DC were activated with LPS. The CD8(+) DC are therefore specialized for in vivo cross-presentation of exogenous soluble Ags into the class I MHC presentation pathway...
  5. pmc Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    PLoS Pathog 3:1240-9. 2007
    ..Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these pathogens remains poorly characterized...
  6. ncbi Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    ..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching...
  7. ncbi The CD8alpha gene locus is regulated by the Ikaros family of proteins
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, NW7 1AA, London, United Kingdom
    Mol Cell 10:1403-15. 2002
    ....
  8. ncbi Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
    D I Godfrey
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 152:4783-92. 1994
    ....
  9. pmc The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    E K Barber
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:3277-81. 1989
    ..Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex...
  10. pmc Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
    R Bosselut
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 190:1517-26. 1999
    ..These results point to a new function for CD4 and CD8 coreceptors in TCR signal transduction, namely to promote LAT phosphorylation by ZAP-70 by recruiting LAT to major histocompatibility complex-engaged TCR complexes...
  11. ncbi RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Immunity 9:839-47. 1998
    ..However, the deficiency in splenic CD8alpha- DEC-205- DC is a direct, stem cell intrinsic effect of the RelB mutation. Thus, RelB selectively regulates a myeloid-related DC lineage...
  12. ncbi Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo
    H R Rodewald
    Basel Institute for Immunology, Switzerland
    Immunity 3:313-9. 1995
    ..Also, the expansion rate of these immature thymocytes in SI/SI graft is reduced by -50%. These experiments provide direct evidence for an important role for c-kit-SCF interactions in expansion of very early thymocytes...
  13. ncbi Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells
    Karin Fischer
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Blood 105:2828-35. 2005
    ..DN Treg cells may serve to limit clonal expansion of allo-Ag-specific T cells after transplantation...
  14. ncbi Mice lacking MHC class II molecules
    D Cosgrove
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 66:1051-66. 1991
    ..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
  15. pmc Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    J J Peschon
    Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 180:1955-60. 1994
    ..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7...
  16. ncbi Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus
    Denise Gangadharan
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    Immunity 25:631-41. 2006
    ....
  17. pmc Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR
    Ivan Bilic
    Institute of Immunology, Medical University of Vienna, Vienna 1090, Austria
    Nat Immunol 7:392-400. 2006
    ..Enforced' expression of MAZR led to impaired Cd8 activation and variegated CD8 expression. Our results demonstrate epigenetic control of the Cd8 loci and identify MAZR as an important regulator of Cd8 expression...
  18. ncbi Cutting edge: in vivo trogocytosis as a mechanism of double negative regulatory T cell-mediated antigen-specific suppression
    Megan S Ford McIntyre
    Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Canada
    J Immunol 181:2271-5. 2008
    ..These data provide new insight into how Tregs mediate Ag-specific T cell suppression and may enhance our ability to use DN Tregs as a therapy for transplant rejection and autoimmune diseases...
  19. ncbi Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13
    Nobuaki Miyahara
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:2549-58. 2004
    ..These data suggest that Ag-primed CD8(+) T cells are required for the full development of AHR and airway inflammation, which appears to be associated with IL-13 production from these primed T cells...
  20. ncbi Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity
    Andrew G Cawthon
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 169:3492-8. 2002
    ..These novel findings provide insights into the control of functional avidity in response to viral infection...
  21. ncbi Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences
    Anna Garefalaki
    National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    Immunity 16:635-47. 2002
    ..Furthermore, these sequences contribute to the levels of expression of the CD8 alpha gene...
  22. pmc Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
    Linda Wooldridge
    T Cell Modulation Group, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Biol Chem 280:27491-501. 2005
    ....
  23. ncbi Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4
    Norbert Kienzle
    Cooperative Research Centre for Vaccine Technology and Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Immunol 174:2021-9. 2005
    ..These data suggest that the CD4-CD8- cells identified in some disease states may be the product of a previously unrecognized pathway of effector differentiation from conventional CD8+ T cells...
  24. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
  25. ncbi Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2
    G F Gao
    Molecular Immunology Group, Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 387:630-4. 1997
    ..Although these shifts in alpha3 may provide a synergistic modulation of affinity, the binding of CD8 to MHC is clearly consistent with an avidity-based contribution from CD8 to TCR-peptide-MHC interactions...
  26. ncbi Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells
    Baerbel Grueter
    Institute of Molecular Biology Cancer Research, University of Essen, Medical School, Essen, Germany
    J Immunol 175:1694-705. 2005
    ..Thus, Runx3 is a main regulator of CD4 silencing and CD103 induction and thus contributes to the phenotype of CD8 SP T cells during thymocyte development...
  27. pmc Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    Ofer Feinerman
    ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 460, New York, NY 10065, USA
    Science 321:1081-4. 2008
    ..These findings reveal how eukaryotic cells can draw on regulated variation in gene expression to achieve phenotypic variability in a controlled manner...
  28. ncbi Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression
    Alexander D McLellan
    Department of Dermatology, University of Wurzburg, Joseph Schneider Strasse 2, Wurzburg 97080, Germany
    Blood 99:2084-93. 2002
    ..Thus, the inability of CD8alpha+ DCs to stimulate CD8+ T cells is limited to certain in vitro assays that must lack certain enhancing signals present during in vivo interaction between CD8alpha+ DCs and CD8+ T cells...
  29. ncbi Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:305-10. 2003
    ..Together these results demonstrate that ICSBP is critically required for the in vivo differentiation of CD8alpha(+) DCs and may also influence the functional maturation of the CD8alpha(-) subsets...
  30. ncbi Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
    J M Turner
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    Cell 60:755-65. 1990
    ..Our results suggest a novel role for cysteine-mediated interactions between unrelated proteins and provide a model for the association of other src-like cytoplasmic kinases with transmembrane proteins...
  31. pmc CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6923-33. 2008
    ..Targeting of Ag to these DCs might be useful for inducing Ag-specific Foxp3(+) Treg for treatment of autoimmune diseases, transplant rejection, and allergy...
  32. pmc Dynamic repositioning of CD4 and CD8 genes during T cell development
    Stephanie Delaire
    Department of Molecular and Cell Biology, 475 Life Science Additions, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 200:1427-35. 2004
    ..We discuss our results in terms of our current knowledge of CD4 and CD8 gene regulation and CD4 versus CD8 lineage commitment...
  33. ncbi Expression of different CD8 isoforms on distinct human lymphocyte subpopulations
    U Moebius
    Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Eur J Immunol 21:1793-800. 1991
    ....
  34. ncbi Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells
    A Hostert
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    Immunity 9:497-508. 1998
    ..Surprisingly, none of the thymocyte or peripheral alphabetaTCR T cell subsets are affected by this mutation, indicating hierarchical activation of these elements within the different T cell subsets...
  35. ncbi A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung
    C D D'Souza
    Mycobacterial Research Laboratories, Departments of Microbiology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    Am J Respir Cell Mol Biol 23:188-93. 2000
    ....
  36. ncbi TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function
    Francine Rezzoug
    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202 1760, USA
    J Immunol 180:49-57. 2008
    ..These data demonstrate a critical role for TNF-alpha in mediating FC function. FC may have a significant impact upon the safe use of chimerism to establish tolerance to transplanted organs and tissue...
  37. pmc ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Exp Med 196:1415-25. 2002
    ....
  38. ncbi Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 305:248-51. 2004
    ..Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue...
  39. ncbi A clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression
    Norbert Kienzle
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Immunol 168:1672-81. 2002
    ..We conclude that IL-4 promotes the development of a noncytolytic CD8(low) T cell phenotype that might be important in tumor- or pathogen-induced immune deviation...
  40. ncbi Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    H Pircher
    Department of Experimental Pathology, University Hospital, Zurich, Switzerland
    Nature 342:559-61. 1989
    ..Thus the same transgenic TCR-expressing T cells may be tolerized at different stages of their maturation and at different locations in the thymus depending on the antigen involved...
  41. ncbi Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 99:2122-30. 2002
    ..Such selective expansion of DC populations and alterations in their cytokine-secretion capacity have implications for clinical use of the studied cytokines in immune modulation...
  42. ncbi Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression
    Wilfried Ellmeier
    Institute of Immunology, University of Vienna, Vienna, Austria
    Immunity 16:623-34. 2002
    ..These results suggest that the initiation of CD8 expression is mediated by cis-regulatory elements that are distinct from any that may be involved in maintenance of expression...
  43. ncbi Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands
    George F Gao
    Nuffield Dept of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
    Trends Immunol 23:408-13. 2002
    ..Here we discuss the interactions of pMHC with the TCR and coreceptor CD8 or CD4 on the surfaces of alphabeta T cells and antigen presenting cells, and the implications for TCR signalling and the T-cell repertoire...
  44. ncbi CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats
    Ekkehard May
    Harold C Simmons Arthritis Research Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Immunol 170:1099-105. 2003
    ..The data also suggest that one or more populations of CD8alpha(+)beta(-) non-T cells may play a role in the arthritis that occurs in these rats...
  45. ncbi Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
    W Ellmeier
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Immunity 9:485-96. 1998
    ..The results suggest that CD8alpha expression is primarily regulated by E8, in IEL and by the novel enhancers in the thymus-dependent lineages...
  46. ncbi Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development
    Nicholas Feik
    Institute of Immunology, Medical University Vienna, Vienna, Austria
    J Immunol 174:1513-24. 2005
    ..These results indicate that E8(III) is one of the cis-elements that contribute to the activation of the Cd8a and Cd8b gene complex during T cell development...
  47. ncbi CD8+ phagocytes in focal ischemia of the rat brain: predominant origin from hematogenous macrophages and targeting to areas of pannecrosis
    M Schroeter
    Department of Neurology and Center for Biological and Medical Research, Heinrich-Heine-University, , Germany
    Acta Neuropathol 101:440-8. 2001
    ..exhibited ED1 immunoreactivity (indicating phagocytic activity), and to some extent expressed CD4, but not CD8 antigens. In conclusion our present study shows that CD8+ phagocytes in focal brain ischemia are predominantly derived ..
  48. ncbi Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer
    L Devine
    Department of Laboratory Medicine, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 164:833-8. 2000
    ..Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed...
  49. ncbi Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus
    R Bosselut
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 12:409-18. 2000
    ..Thus, this study identifies the molecular functions of the CD8beta intracellular and extracellular domains and documents their contributions to CD8+ T cell development...
  50. ncbi Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
    Blood 99:1706-14. 2002
    ..These findings suggest that interaction between sHLA-I and CD8 evokes an apoptotic signal that is down-regulated by inhibitory receptor superfamily that function as survival receptors in NK cells...
  51. ncbi Molecular interactions mediating T cell antigen recognition
    P Anton van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Annu Rev Immunol 21:659-84. 2003
    ..These studies provide the necessary framework for exploring how these molecular interactions initiate T cell activation...
  52. ncbi Role of double-negative regulatory T cells in long-term cardiac xenograft survival
    Wenhao Chen
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2C4 Canada
    J Immunol 170:1846-53. 2003
    ....
  53. ncbi Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling
    Roben Fragoso
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York 10016, USA
    J Immunol 170:913-21. 2003
    ..Thus, our data suggest that CD4-induced aggregation of lipid rafts may play an additional role in CD4 signaling besides its adhesion to MHC molecules and association with Lck...
  54. ncbi Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody
    H Pircher
    Institute of Pathology, University Hospital, Zurich, Switzerland
    Eur J Immunol 22:399-404. 1992
    ....
  55. pmc Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice
    J C Zuniga-Pflucker
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 180:1517-21. 1994
    ..Our findings provide evidence for a novel pathway that allows the transition of thymocytes from the CD4-/CD8- to the CD4+/CD8+ stage and that does not appear to require TCR-beta chain rearrangement...
  56. ncbi Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface
    Linda Wooldridge
    T Cell Modulation Group, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    J Immunol 171:6650-60. 2003
    ..These results question many previous assumptions as to how anti-CD8 Abs must function and indicate that CD8 has multiple roles in CTL activation that are not necessarily dependent on an interaction with pMHCI...
  57. ncbi The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies
    S P Cobbold
    Division of Immunology, University of Cambridge, GB
    Eur J Immunol 20:2747-55. 1990
    ..The introduction of comparable tolerance-inducing regimens in clinical organ transplantation could obviate the need for long-term immunosuppression and its unfortunate side effects...
  58. pmc Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
    D Brändle
    Institute of Experimental Immunology, University of Zurich, Switzerland
    Proc Natl Acad Sci U S A 89:9529-33. 1992
    ..Our findings suggest that binding of the TCR to self MHC molecules during positive selection down-regulates RAG-1 transcription in cortical thymocytes and thereby prevents further TCR alpha-chain rearrangements...
  59. ncbi Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
    C B Davis
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414
    Cell 73:237-47. 1993
    ....
  60. pmc A transcriptional silencer controls the developmental expression of the CD4 gene
    G Siu
    Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    EMBO J 13:3570-9. 1994
    ....
  61. pmc Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
    Emma Gostick
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 37:479-86. 2007
    ..This latter effect may provide a fundamental new mechanism with which to enhance T cell immunity to specific antigens...
  62. ncbi Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain
    M E Crooks
    Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Immunity 1:277-85. 1994
    ..By breeding CD8 beta null mice with animals expressing a class I-specific TCR transgene, we show that CD8 beta plays a significant role in both positive and negative selection of developing thymocytes...
  63. pmc The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
    A M Cheng
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Proc Natl Acad Sci U S A 94:9797-801. 1997
    ..These data suggest that the ZAP-70 and Syk tyrosine kinases have crucial but overlapping functions in signaling from the pre-TCR and hence in early thymocyte development...
  64. pmc Disparate immunoregulatory potentials for double-negative (CD4- CD8-) alpha beta and gamma delta T cells from human patients with cutaneous leishmaniasis
    Lis R V Antonelli
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, and Immunology Service, Hospital Edgard Santos, Bahia, Brazil
    Infect Immun 74:6317-23. 2006
    ..The balance between these subpopulations could allow for the formation of an effective cellular response while limiting its pathogenic potential...
  65. pmc Cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells is attributable to their ability to internalize dead cells
    Oliver Schulz
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Immunology 107:183-9. 2002
    ....
  66. pmc The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages
    M C Haks
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 17:1871-82. 1998
    ..The defect in the DN to double positive transition in mice lacking CD3gamma can be overcome by anti-CD3epsilon-mediated cross-linking. CD3gamma is thus essential for pre-TCR function...
  67. ncbi bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
    C L Sentman
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 67:879-88. 1991
    ..This transgenic model indicates that multiple death pathways operate within the thymus that can be distinguished by their dependence on bcl-2...
  68. pmc Thymic tumorigenesis induced by overexpression of p56lck
    K M Abraham
    Howard Hughes Medical Institute, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 88:3977-81. 1991
    ..The sensitivity of thymocytes to p56lck-induced transformation suggests that disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases...
  69. ncbi Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  70. ncbi Timing and casting for actors of thymic negative selection
    N Dautigny
    Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
    J Immunol 162:1294-302. 1999
    ..Finally, we show involvement in opposing directions for p59fyn and SHP-1 molecules in signaling for thymic negative selection...
  71. ncbi Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1
    Christopher M Smith
    Cooperative Research Center for Vaccine Technology, University of Melbourne, Victoria, Australia
    J Immunol 170:4437-40. 2003
    ..Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus...
  72. ncbi Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger"
    Alexandra J Corbett
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Eur J Immunol 35:2815-25. 2005
    ....
  73. ncbi Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
    P Mombaerts
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts
    Nature 360:225-31. 1992
    ..TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta...
  74. ncbi Requirement for CD8 beta chain in positive selection of CD8-lineage T cells
    K Nakayama
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
    Science 263:1131-3. 1994
    ..The number of peripheral CD8+ T cells was restored by transfer of an exogenous CD8 beta gene into CD8 beta-deficient T cells. Thus, CD8 beta is necessary for the maturation of CD8+ T cells...
  75. ncbi Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes
    R Bosselut
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 14:483-94. 2001
    ....
  76. pmc Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice
    T Moroy
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    Proc Natl Acad Sci U S A 90:10734-8. 1993
    ..These results show that Pim-1 can strongly accelerate lymphoproliferation through inhibition of apoptosis and thereby provide first insight into the functional basis for the oncogenic activity of Pim-1...
  77. ncbi An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
    P Mombaerts
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Immunity 1:261-7. 1994
    ..In addition, p56lck may be involved in the down-regulation of the putative pre-TCR on CD4+CD8+ thymocytes...
  78. ncbi CD8alpha+ dendritic cells originate from the CD8alpha- dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulation
    Gloria Martinez del Hoyo
    Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Blood 99:999-1004. 2002
    ....
  79. ncbi Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection
    Amalia Penna
    Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Hepatology 45:588-601. 2007
    ..The CD8 dysfunction was associated with high PD-1 expression by most HCV-specific CD8 cells, and PD-1/PD-L1 blockade by anti-PD-L1 antibodies in vitro was able to improve the HCV-specific CD8 function...
  80. ncbi A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice
    A Hostert
    Laboratory of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 158:4270-81. 1997
    ....
  81. ncbi Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb
    P S Kern
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Immunity 9:519-30. 1998
    ....
  82. ncbi ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 101:961-9. 2003
    ..Taken together, this study identifies ICSBP as a factor critical for both early differentiation and final maturation of DCs...
  83. ncbi CD3 delta establishes a functional link between the T cell receptor and CD8
    Marie Agnès Doucey
    Institute for Biochemistry, University of Lausanne, Epalinges 1066, Switzerland
    J Biol Chem 278:3257-64. 2003
    ..Thus, CD3 delta couples TCR.CD3 with raft-associated CD8, which is required for effective activation and positive selection of CD8(+) T cells...
  84. ncbi The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain
    M A Purbhoo
    University of Oxford, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    J Biol Chem 276:32786-92. 2001
    ..These reagents may prove useful in circumventing undesirable activation-related perturbation of intracellular processes when pMHC multimers are used to phenotype antigen-specific CD8+ lymphocytes...
  85. ncbi Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
    B H Koller
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 248:1227-30. 1990
    ..The homozygotes appeared normal, although no class I antigens could be detected on their cells and the animals are grossly deficient in CD4- CD8+ T cells, which normally mediate cytotoxic T cell function...
  86. pmc Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells
    M Eichelberger
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    J Exp Med 174:875-80. 1991
    ....
  87. ncbi T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL
    A J Leishman
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 294:1936-9. 2001
    ..These findings define a novel mechanism of lymphocyte regulation through CD8alphaalpha and MHC class I...
  88. pmc Mice lacking major histocompatibility complex class I and class II molecules
    M J Grusby
    Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3913-7. 1993
    ..Taken together, these results emphasize the plasticity of the immune system and suggest that MHC-deficient mice may be useful for examining compensatory mechanisms in severely immunocompromised animals...
  89. pmc Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:10122-6. 2004
    ..Such data question whether CD4(+)CD25(+) regulatory T cells alone can account for the antigen specificity of dominant transplantation tolerance...
  90. ncbi Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
    Mark A Daniels
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Nature 444:724-9. 2006
    ....
  91. ncbi Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors
    Megan S Ford
    Multiorgan Transplantation Program, Toronto General Research Institute, University Health Network, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    J Immunol 177:2803-9. 2006
    ..These data suggest that DN Tregs may represent a developmentally and functionally unique cell population...
  92. ncbi Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples
    Stuart P Berzins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    Eur J Immunol 35:1399-407. 2005
    ..Interestingly, while thymus and peripheral NKT cell frequencies vary widely between patients and are relatively stable between age groups, there is no clear relationship between the NKT cell frequency in thymus and blood...
  93. pmc The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
    Petra Schnorrer
    Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:10729-34. 2006
    ..This conclusion has important implications for the design of vaccination strategies based on antigen targeting to DC...
  94. pmc Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
    Matthew N J Seaman
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, England, UK
    J Cell Biol 165:111-22. 2004
    ..The data presented here support the hypothesis that retromer performs a selective function in endosome-to-Golgi transport, mediating retrieval of the CI-MPR, but not furin...
  95. ncbi CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice
    Weimin Zhong
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 35:3103-10. 2005
    ..Further studies are needed to define those ligands that induce CD8alphaalpha on T cells during acute viral infections, and the general relevance of this process to memory T cell formation...
  96. pmc Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
    David Sancho
    Immunobiology Laboratory, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 458:899-903. 2009
    ..Thus, CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens...
  97. pmc CD8+ phagocyte recruitment in rat experimental autoimmune encephalomyelitis: association with inflammatory tissue destruction
    Michael Schroeter
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Am J Pathol 163:1517-24. 2003
    ....
  98. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
    ..We conclude that DNGR-1 is a novel, highly specific marker of mouse and human DC subsets that can be exploited for CTL cross-priming and tumor therapy...
  99. pmc Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha
    Anmol Chandele
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:5619-23. 2005
    ..Our results indicate that memory CD8 T cell development can occur independently of CD8alphaalpha...
  100. ncbi Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding
    A M Moody
    Laboratory of Immunobiology, Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Cell 107:501-12. 2001
    ..Hence, glycans on the CD8beta stalk appear to modulate the ability of the distal binding surface of the dimeric CD8 globular head domains to clamp MHCI...
  101. ncbi Zinc is essential for binding of p56(lck) to CD4 and CD8alpha
    R S Lin
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 273:32878-82. 1998
    ..p56(lck) complexes. CD4. p56(lck) and CD8alpha.p56(lck) represent the first examples of intracellular proteins that require zinc as a bridge for heterodimerization...

Research Grants62

  1. A CD8+ T cell diagnostic to identify children with pulmonary tuberculosis
    Melissa R Nyendak; Fiscal Year: 2013
    ..approach to define regions enriched for high affinity binding to HLA within these 45 immunodominant CD8 antigens. We selected 166 peptides representing these regions likely to contain clusters of immunogenic epitopes, and ..
  2. A CD8+ T cell diagnostic to identify children with pulmonary tuberculosis
    Melissa R Nyendak; Fiscal Year: 2012
    ..diagnostic, we plan to use a bioinformatic approach to define peptides within these 45 immunodominant CD8 antigens likely to contain clusters of immunogenic epitopes...
  3. Adoptive T Cell Therapy Following CD25 Lymphodepletion
    Cassian Yee; Fiscal Year: 2010
    ....
  4. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2007
    ..during viral entry, and HSV-2 proteins that are synthesized shortly after infection, are the immunodominant CD8 antigens of HSV-2...
  5. Generation of therapeutic T cells from cord blood-derived stem cells
    Krishnendu Roy; Fiscal Year: 2009
    ..We would also investigate if tetramer signaling through magnetic microbeads (artificial antigen presenting cells) can further differentiate these stem cell-derived early T cells into more mature, CD8+ antigen specific T cells. ..
  6. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2009
    ....
  7. CD4/CD8 P56LCK AND ASSOCIATED KINASES
    CHRISTOPHER RUDD; Fiscal Year: 2000
    ..In Aim #2, we propose to map the site of binding within the CD4 and CD8 antigens and to determine the identity of the PI 4-kinase...
  8. STRUCTURE AND FUNCTION OF HUMAN CD8 ALPHA AND CD8 BETA
    Neal Flomenberg; Fiscal Year: 1992
    ..To assess whether T-cells bearing only CD8 alpha/alpha homodimers have different requirements for activation and/or inhibition of function than T -cells which express both CD8 alpha and CD8 beta...
  9. Adoptive T Cell Therapy Following Lymphodepletion
    Cassian Yee; Fiscal Year: 2004
    ..abstract_text> ..
  10. Molecular Interactions in the Aging Immunological Synapse
    NICHOLAS GASCOIGNE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  11. SELECTION OF T-CELL RECEPTOR V-ALPHA REGIONS
    NICHOLAS GASCOIGNE; Fiscal Year: 2009
    ....
  12. A novel protein regulating thymocyte development
    NICHOLAS R GASCOIGNE; Fiscal Year: 2010
    ..This newly discovered protein appears to regulate these processes, thus this project will uncover how this novel protein functions. ..
  13. Leica TCSSP2RS two-photon microscope for in vivo imaging
    NICHOLAS GASCOIGNE; Fiscal Year: 2006
    ..Overall, this instrument will allow the user group to radically improve their ability to perform experiments on understanding the immune system in development and disease. [unreadable] [unreadable] [unreadable]..
  14. SOLUBLE T CELL RECEPTOR STUDIES ON MHC RESTRICTION
    NICHOLAS GASCOIGNE; Fiscal Year: 2006
    ..TCR dimerization will be investigated in solution, using biophysical methods including FRET, analytical ultracentrifugation and BIAcore. ..
  15. Cannabinoid Receptor Dynamics in T Cell Activation
    NICHOLAS GASCOIGNE; Fiscal Year: 2002
    ..We will express fluorescent CB2 in APC, to see how expression is affected by drug exposure and by interaction with T cells. ..
  16. Real-time molecular interactions in tolerance induction
    NICHOLAS GASCOIGNE; Fiscal Year: 2003
    ..Conditions where naive T cells are tolerized in peripheral (pancreatic) lymph nodes or activated for diabetes will be analyzed. ..
  17. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
  18. MOLECULAR BASIS OF CD8 CO-RECEPTOR FUNCTION
    Hsiu Ching Chang; Fiscal Year: 2004
    ..In parallel, the potential molecules involved in signal transduction of CD8beta will be cloned in the yeast two hybrid system. ..
  19. INDUCTION OF SPECIFIC IMMUNE TOLERANCE
    TERRY POTTER; Fiscal Year: 2003
    ..In the current application, it is proposed to examine the function and activity of the CD8 targeting hAb in animal models of organ transplantation. ..
  20. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
    ..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
  21. Screen for Small Molecule Compounds that Modulate the Transcriptional Activity of
    Dan Littman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Rational Design of HMW-MAA Peptide Mimics
    Soldano Ferrone; Fiscal Year: 2008
    ..abstract_text> ..
  23. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  24. Aging and thymopoiesis: Changes in stroma, T-presursors
    Phong Le; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. MURINE MODEL SYSTEM FOR HIV PATHOGENESIS
    Dan Littman; Fiscal Year: 2008
    ..RNA interference and gene targeting will be used to reduce expression of the mouse enzyme, and we will engineer HIV with Vif that can bind to and induce degradation of mouse apobec3g. [unreadable] [unreadable]..
  26. Structure, Function and Engineering of T Cell Receptors
    DAVID KRANZ; Fiscal Year: 2009
    ..Mutations at V:C and Va:Vp interfaces will be introduced into a T cell transfection system to examine their possible influence on T cell activation. ..
  27. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  28. LISTERIA PROTEINS EFFECTS ON CELL FUNCTION
    TERRY POTTER; Fiscal Year: 2001
    ..These experiments should provide valuable information on the interaction of LM with phagocytic cells and may provide insights into the phagocytosis and killing of other intracellular bacteria. ..
  29. Antigen processing and HLA-peptide complexes in head and neck cancer
    Soldano Ferrone; Fiscal Year: 2010
    ..abstract_text> ..
  30. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
    ..Relevance ..
  31. Role of T Cells in Experimental Spondyloarthropathy
    JOEL TAUROG; Fiscal Year: 2002
    ..These experiments will examine directly the effect of Tap2a on the B27 peptide repertoire and on disease manifestations. ..
  32. Cellular MRI in Glioma and Radiation Necrosis
    Ali Syed Arbab; Fiscal Year: 2010
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..
  33. Molecular Triggers of T Helper Lineage Choice
    Dietmar J Kappes; Fiscal Year: 2010
    ..These experiments should provide insights into the molecular basis of alternate TCR signaling and the mechanism of lineage commitment. ..
  34. Mouse model of oral infection with virulent Francisella
    Wangxue Chen; Fiscal Year: 2005
    ..tularensis infection so that future hypothesis-driven studies with more focused research objectives can be designed and developed. ..
  35. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ....
  36. The Role of Toll-Like Receptors in Cancer Immunotherapy
    Yiping Yang; Fiscal Year: 2009
    ..The outcome of these studies should have significant impact on the design of effective immunotherapeutic strategies for treating cancer. ..
  37. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  38. CONTROL OF LINEAGE COMMITMENT IN DEVELOPING THYMOCYTES
    Dietmar Kappes; Fiscal Year: 2008
    ..2) To determine how cKrox activity is differentially regulated in class I- versus class II-specific thymocytes. 3) To functionally dissect the roles of the zinc finger and BTB/POZ domains of cKrox in lineage commitment. ..
  39. MACROPHAGE HETEROGENEITY AFTER SPINAL CORD INJURY
    Phillip Popovich; Fiscal Year: 2008
    ..In this way, CNS macrophages could be used as vehicles for drug delivery. [unreadable] [unreadable]..
  40. BLyS, APRIL and antibody production in HIV infection
    Andrea Cerutti; Fiscal Year: 2004
    ..Aim 1. To analyze the mechanisms by which HIV up-regulates BLyS and APRIL in APCs. Aim 2. To analyze the role of BLyS and APRIL in the modulation of HIV-induced antibody production. ..
  41. Cellular Activation Pathways in Rheumatoid Arthritis
    Joseph Holoshitz; Fiscal Year: 2004
    ..The proposed studies will likely contribute significantly to understanding the pathogenesis of RA and, perhaps, other autoimmune diseases. ..
  42. Immunotherapy for Epstein-Barr Virus-associated Malignan
    Yiping Yang; Fiscal Year: 2004
    ..These EBV-associated tumors are seen as models for other tumors in which tumor specific antigens have been identified and the development of novel therapeutic approaches. ..
  43. Exercise & influenza immunity:Psychoneuroendocrine Model
    Marian Kohut; Fiscal Year: 2004
    ..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
  44. TESTING A MODEL OF RISK REDUCTION FOR HIV POSITIVE WOMEN
    Gail Wyatt; Fiscal Year: 2003
    ....
  45. HLA CLASS I PEPTIDE COMPLEX ADNORMALITIES IN MELANOMA
    Soldano Ferrone; Fiscal Year: 2004
    ..Furthermore, the outlined studies are expected to yield methodology and reagents which will be very useful to screen and monitor patients with malignant diseases to be treated with T cell-based immunotherapy. ..
  46. Conference Proposal: Transplantation Immunology
    Angus Thomson; Fiscal Year: 2004
    ..An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research. ..
  47. BASIC AND CLINICAL RHEUMATOLOGY
    JOEL TAUROG; Fiscal Year: 2005
    ..Simmons Arthritis Research Center, University of Texas Southwestern Medical Center. ..
  48. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  49. SIMIAN AIDS: SOCIAL STRESS, ENDOCRINE & IMMUNE FUNCTION
    John Capitanio; Fiscal Year: 2004
    ..abstract_text> ..
  50. Transcytosis of Flagellin Across Airway Epithelia
    ERIK LILLEHOJ; Fiscal Year: 2008
    ..Based on previous studies of ourselvesand others, we suggest that a major bacterial component (flagellin) is processed differently in CF lungs, leading to enhanced inflammatory responses. ..
  51. Development of gene targeting in C. elegans and D. rerio using zinc finger
    Matthew Porteus; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Chemokines and lymphocyte trafficking into the CNS
    Robyn Klein; Fiscal Year: 2007
    ..As evidenced by almost nine years of research in the neurosciences, the applicant remains firmly committed to a long-term career in basic science investigation. ..
  53. CELLULAR FACTORS REQUIRED FOR HIV ENTRY
    Dan Littman; Fiscal Year: 2007
    ..The results of these studies should provide insight into[unreadable] the complex mechanism of HIV entry and may suggest novel approaches for[unreadable] interfering with the earliest step in the HIV life cycle.[unreadable]..
  54. Human Bone Marrow Derived Neural Stem Cell Therapy
    John Yu; Fiscal Year: 2006
    ..3) Human BM-NSC is safe and effective in an experimental rodent glioma model. ..
  55. HIV ENV & MACROPHAGE CHEMOKINE RECEPTOR IONIC SIGNALING
    Bruce Freedman; Fiscal Year: 2004
    ....
  56. T Lymphocyte Apoptosis in Hepatitis C Persistence
    Margaret Koziel; Fiscal Year: 2006
    ..abstract_text> ..
  57. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004
    ..We will examine the roles of the protein kinase C and protein phosphatase families of enzymes in regulating galectin1 cell death. We determine how galectin-3 expression regulates T-cell susceptibility to galectin-1. ..
  58. A Class II MHC-Associated Lymphocyte Activation Defect
    Joseph Holoshitz; Fiscal Year: 2006
    ..These studies will examine a novel paradigm relevant to a physiologic regulatory mechanism in the immune system, whose perturbation may set the stage for immunopathology. ..
  59. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..