Genomes and Genes
Summary: A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers.
Publications262 found, 100 shown here
- DCs induce CD40-independent immunoglobulin class switching through BLyS and APRILMikhail B Litinskiy
Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Nat Immunol 3:822-9. 2002..By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses...
- Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell toleranceLaura Bonifaz
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 196:1627-38. 2002..Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation...
- A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cellJ P Ridge
Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
Nature 393:474-8. 1998....
- TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingM A Lomaga
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
Genes Dev 13:1015-24. 1999..These findings establish unexpectedly diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling...
- CD40-CD40 ligandC van Kooten
Department of Nephrology, Leiden University Medical Center, The Netherlands
J Leukoc Biol 67:2-17. 2000....
- A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memoryChristine Bourgeois
INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
Science 297:2060-3. 2002..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
- CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cellsV Henn
Molecular Immunology, Robert Koch Institute, Berlin, Germany
Nature 391:591-4. 1998..Our results indicate that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall...
- T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactionsS P Schoenberger
Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
Nature 393:480-3. 1998..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
- TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40M Rothe
Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
Science 269:1424-7. 1995..A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant-negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD40. Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling...
- Reduction of atherosclerosis in mice by inhibition of CD40 signallingF Mach
Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 394:200-3. 1998..These data support the involvement of inflammatory pathways in atherosclerosis and indicate a role for CD40 signalling during atherogenesis in hyperlipidaemic mice...
- Endotoxin-induced maturation of MyD88-deficient dendritic cellsT Kaisho
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
J Immunol 166:5688-94. 2001..Collectively, the present study provides the first evidence that the MyD88-independent pathway downstream of TLR4 can lead to functional DC maturation, which is critical for a link between innate and adaptive immunity...
- Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8Mariola Fotin-Mleczek
Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
J Cell Sci 115:2757-70. 2002..Hence, TNF-R2 triggering can interfere with TNF-R1-induced apoptosis by inhibition of NF-kappaB-dependent production of anti-apoptotic factors and by blocking the action of anti-apoptotic factors at the post-transcriptional level...
- Impairment of antigen-specific T-cell priming in mice lacking CD40 ligandI S Grewal
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nature 378:617-20. 1995....
- Inhibition of CD40 signaling limits evolution of established atherosclerosis in miceU Schonbeck
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 97:7458-63. 2000..This study lends further support to the importance of this specific inflammatory signaling pathway in atherosclerosis and its complications...
- TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signalingT K Ishida
Department of Oncology, University of Tokyo, Japan
Proc Natl Acad Sci U S A 93:9437-42. 1996..These results suggest that TRAF5 and TRAF3 could be involved in both common and distinct signaling pathways emanating from CD40...
- Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivoDouglas G Millar
Departments of Immunology and Medical Biophysics, University Health Network, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
Nat Med 9:1469-76. 2003..In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo...
- CD40 and dendritic cell functionBrendan O'Sullivan
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland 4102, Australia
Crit Rev Immunol 23:83-107. 2003..CD40 may also play an important role in the decision between tolerance and immunity and the generation of regulatory CD4+ T cells that are thought to maintain peripheral self-tolerance in vivo...
- A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiologyEric M Jacobson
Division of Endocrinology, Box 1055, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
Endocrinology 146:2684-91. 2005..Therefore, our results may suggest that the C allele of the CD40 Kozak SNP, which is associated with Graves' disease, could predispose to disease by increasing the efficiency of translation of CD40 mRNA...
- Dendritic cell maturation is required for the cross-tolerization of CD8+ T cellsM L Albert
Laboratory of Neuro Oncology, The Rockefeller University, 1230 York Avenue, Box 26, New York, NY 10021, USA
Nat Immunol 2:1010-7. 2001....
- IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cellsRachel Ettinger
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
J Immunol 175:7867-79. 2005..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
- CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expressionK Karmann
Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 92:4342-6. 1995..CD40 may be detected immunocytochemically on human microvascular EC in normal skin. We conclude that endothelial CD40 may play a role as a signaling receptor in the development of T-cell-mediated inflammatory reactions...
- Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturationLelia Delamarre
Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520 8002, USA
J Exp Med 198:111-22. 2003..Thus, the MHC I and MHC II pathways of antigen presentation are differentially regulated during DC maturation...
- Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivoD Hawiger
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 194:769-79. 2001..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
- The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndromeA Aruffo
Bristol Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121
Cell 72:291-300. 1993..The gene encoding gp39 was mapped to Xq26, the X chromosome region where the gene responsible for HIM had previously been mapped. These data suggest that a defect in gp39 is the basis of X-linked HIM...
- TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responsesL T Nguyen
Department of Immunology, University of Toronto, Ontario, Canada
Immunity 11:379-89. 1999..These data demonstrate two important roles of TRAF2, one as a negative regulator of certain TNFR1 signals and the other as a positive mediator of CD40 signaling...
- Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunityXinan Jiao
Unité de Biologie des Régulations Immunitaires, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
J Immunol 168:1294-301. 2002..Strikingly, BCG bacilli survive but remain stable in number in the DC leukocyte subset during the first 2 wk of infection. As Ag presentation by DC is rapidly lost, this suggests that DC may represent a hidden reservoir for mycobacteria...
- Short-circuiting long-lived humoral immunity by the heightened engagement of CD40Loren D Erickson
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Clin Invest 109:613-20. 2002..These are the first studies to describe the multifaceted function of CD40 in determining the fate of antigen-reactive B cells and provide novel insights into how CD40 agonists can short-circuit humoral immunity...
- RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapyChristina M Coughlin
Division of Hematology and Oncology, Children s Hospital of Philadelphia, and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 19104, USA
Blood 103:2046-54. 2004..These findings support a novel platform for tumor-specific vaccine or adoptive immunotherapies in pediatric malignancies...
- TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationM F Bachmann
Basel Institute for Immunology, CH 4005 Basel, Switzerland
J Exp Med 189:1025-31. 1999..Moreover, the data suggest that TRANCE/TRANCE-R may be a novel and important target for immune intervention...
- The multi-functionality of CD40L and its receptor CD40 in atherosclerosisDirk Lievens
Department of Pathology, University of Maastricht, 6229 HX Maastricht, The Netherlands
Thromb Haemost 102:206-14. 2009..In this review, we highlight the cell-type specific multi-functionality of CD40-CD40L signalling in atherosclerosis...
- Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myelomaJonathan J Keats
Comprehensive Cancer Center, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
Cancer Cell 12:131-44. 2007..These results highlight the critical importance of the NF-kappaB pathway in the pathogenesis of multiple myeloma...
- Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosisF Mach
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 94:1931-6. 1997....
- CD40 ligand gene defects responsible for X-linked hyper-IgM syndromeR C Allen
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
Science 259:990-3. 1993..Thus, these CD40L defects lead to a T cell abnormality that results in the failure of patient B cells to undergo immunoglobulin class switching...
- The CD40/CD154 receptor/ligand dyadU Schonbeck
Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Mol Life Sci 58:4-43. 2001....
- TRAF proteins in CD40 signalingGail A Bishop
Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa and the Iowa City VAMC, Iowa City, Iowa 52242, USA
Adv Exp Med Biol 597:131-51. 2007..This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions...
- CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cellsGiandomenica Iezzi
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
Proc Natl Acad Sci U S A 106:876-81. 2009..Our data demonstrate that CD40-CD40L cross-talk is important for Th17 development by translating strong T cell receptor and microbial stimuli into IL-6 production...
- Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6Gaetan Jego
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
Immunity 19:225-34. 2003..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
- CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cellsY Zhang
Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Virol 74:8003-10. 2000....
- CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamilyA G Eliopoulos
CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
Mol Cell Biol 20:5503-15. 2000..These findings identify a novel proapoptotic mechanism which is induced by CD40 in carcinoma cells and depends on the endogenous production of cytotoxic cytokines and autocrine or paracrine induction of cell death...
- CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokinesY Wang
Peter Gorer Department of Immunobiology, Guy's, King's, and St. Thomas' Medical School, KCL, London, United Kingdom
Immunity 15:971-83. 2001..Coimmunoprecipitation of Mtb HSP70 with CD40 indicates a physical association between these molecules. The results suggest that CD40 is critical in microbial HSP70 binding and stimulation of RANTES production...
- Functions of CD40 on B cells, dendritic cells and other cellsC van Kooten
Department of Nephrology, Leiden University Hospital, 1 C3P, Albinusdreef 2, 2333 AA, Leiden, The Netherlands
Curr Opin Immunol 9:330-7. 1997..Finally, the critical role of CD40-CD40L interactions in the development of various disease states has been fully appreciated...
- Help for cytotoxic-T-cell responses is mediated by CD40 signallingS R Bennett
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
Nature 393:478-80. 1998....
- Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytesPing Xie
Department of Microbiology, University of Iowa, Iowa City 52242, USA
J Exp Med 199:661-71. 2004..Our data reveal that CD40 and LMP1 unexpectedly use TRAF3 in different ways, and that TRAF3 is required for LMP1-mediated activation of B cells...
- Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytesF Rousset
Schering Plough, Laboratory for Immunological Research, Dardilly, France
Proc Natl Acad Sci U S A 89:1890-3. 1992..Thus, IL-10 may play an important role in the amplification of humoral responses...
- Crystallographic analysis of CD40 recognition and signaling by human TRAF2S M McWhirter
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3206, USA
Proc Natl Acad Sci U S A 96:8408-13. 1999..The spacing between the CD40 binding sites on TRAF2 supports an elegant signaling mechanism in which trimeric, extracellular ligands preorganize the receptors to simultaneously recognize three sites on the TRAF trimer...
- Multiple roles of TRAF3 signaling in lymphocyte functionGail A Bishop
Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
Immunol Res 39:22-32. 2007..TRAF3 is also important for signaling via innate immune receptors, as well as an oncogenic mimic of a normal receptor that is implicated in promoting both malignancies and autoimmunity...
- Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administrationKristin Hochweller
ICAPB, University of Edinburgh, Edinburgh, GB
Eur J Immunol 34:990-8. 2004..These data implicate the CD40:CD40L interaction as a key checkpoint in the development of T cell immunity rather than tolerance...
- NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytesH H Lee
Department of Microbiology and Molecular Genetics, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 96:9136-41. 1999..Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members...
- DC-NK cell cross talk as a novel CD4+ T-cell-independent pathway for antitumor CTL inductionChristian Adam
GSF Institut für Molekulare Immunologie, Marchioninistr 25, D 81377 Munchen, Germany
Blood 106:338-44. 2005..This pathway was dependent on inter-feron-gamma expression and involved priming endogenous DCs for interleukin-12 production. Our data suggest a novel pathway linking innate and adaptive immunity...
- CD40 and autoimmunity: the dark side of a great activatorAnna L Peters
Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
Semin Immunol 21:293-300. 2009..This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy...
- Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytesGail A Bishop
Department of Microbiology, 3 570 Bowen Science Building, The University of Iowa, Iowa City, IA 52242, USA
J Leukoc Biol 72:19-23. 2002..For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview...
- Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infectionL Soong
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Immunity 4:263-73. 1996..These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite...
- Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responsesL Boon
Tanox Pharma B.V, Amsterdam, The Netherlands
J Immunol 167:2942-9. 2001....
- T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activationSimon Fillatreau
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
J Exp Med 197:195-206. 2003..Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice...
- Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cellsJian Zheng
Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People s Republic of China
J Immunol 183:3742-50. 2009..This approach may facilitate the clinical application of CD8(+) Treg-based immunotherapy in transplantation and autoimmune diseases...
- The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunityS R Clarke
Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle 98195 7370, USA
J Leukoc Biol 67:607-14. 2000..It is important that CD40 and its ligand, CD40L, have been implicated in the provision of this help and, in particular, the generation of long-lasting CTL memory...
- Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)K D Brown
Medical Scientist Training Program, University of Iowa, Iowa City 52242, USA
J Exp Med 193:943-54. 2001..This suggests that LMP1 utilizes a modified CD40 signaling pathway. Failure to regulate TRAFs may contribute to the enhanced capacity of LMP1 to activate B cells as well as promote B cell transformation...
- Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implicationsYu Tzu Tai
Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Res 65:11712-20. 2005....
- IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cellsS Nakae
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
J Immunol 167:90-7. 2001..These observations indicate that IL-1 enhances T cell-dependent Ab production by augmenting CD40 ligand and OX40 expression on T cells...
- ICOS is critical for CD40-mediated antibody class switchingA J McAdam
Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 409:102-5. 2001..Class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway...
- Potent adjuvant effect by anti-CD40 in collagen-induced arthritis. Enhanced disease is accompanied by increased production of collagen type-II reactive IgG2a and IFN-gammaA C Tellander
Active Biotech Research AB, Lund, Sweden
J Autoimmun 14:295-302. 2000..In conclusion, our results indicate that the level of CD40 activation during the induction of an autoimmune response may determine the severity of the resulting disease...
- CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerizationS S Pullen
Department of Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
Biochemistry 37:11836-45. 1998..Relative affinities and competition of individual and hetero-oligomeric TRAF proteins for CD40 binding sites may contribute to receptor specificity and cell-type selectivity in CD40-dependent signaling...
- Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40Che Leung Law
Seattle Genetics, Inc, Bothell, Washington 98021, USA
Cancer Res 65:8331-8. 2005..The preclinical in vitro and in vivo antilymphoma activity of SGN-40 observed in this study provides a rationale for the clinical testing of SGN-40 in the treatment of CD40+ B-lineage lymphomas...
- CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvantsMichael von Bergwelt-Baildon
Molecular Tumor Biology and Tumor Immunology, Clinic I of Internal Medicine, Hematology Oncology, Kerpener Str 62, 50924 Köln, Germany
Blood 107:2786-9. 2006..Furthermore, we show that CD40-B cells express important T-cell attractants and induce strong T-cell chemotaxis. These findings further support the use of CD40-B cells as cellular adjuvant for cancer immunotherapy...
- Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)Kathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am Heart J 151:706-11. 2006..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion...
- Inhibitory effects of B cells on antitumor immunitySatoshi Inoue
Center for Biologics Evaluation and Research, Division of Hematology, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
Cancer Res 66:7741-7. 2006..Our studies provide the first mechanistic basis for the concept that B-cell depletion could therapeutically enhance antitumor immune responses to certain tumors by decreasing IL-10 production from B cells...
- Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRILBing He
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Immunity 26:812-26. 2007..Thus, mucosal vaccines should activate IECs to induce more effective IgA(2) responses...
- Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibodyRobert H Vonderheide
Abramson Family Cancer Research Institute, Abramson Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Oncol 25:876-83. 2007..CD40 is also expressed by solid tumors, but its engagement results in apoptosis. CP-870,893, a fully human and selective CD40 agonist monoclonal antibody (mAb), was tested for safety in a phase I dose-escalation study...
- CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBPMekhine Baccam
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 170:3099-108. 2003..Furthermore, CD40 stimulation led to phosphorylation of c-Jun on its activation domain, implicating CD40-mediated Jun kinase activation in the transcriptional regulation of IL-6 production...
- Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactionsA J Miga
Department of Microbiology, Dartmouth Medical School, Lebanon, USA
Eur J Immunol 31:959-65. 2001..Hence, the profound impact of CD154 deficiency on cell-mediated immunity may be due to its ability to limit the duration of antigen presentation in vivo and cause the premature demise of antigen-specific T cells...
- CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigrationJon D Vogel
Division of Gastroenterology, University Hospitals of Cleveland, Case Western University School of Medicine, Cleveland, OH 44106, USA
Gastroenterology 126:63-80. 2004....
- The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formationT Kawabe
Institute for Molecular and Cellular Biology, Osaka University, Japan
Immunity 1:167-78. 1994..These results suggest that CD40 is essential for T cell-dependent immunoglobulin class switching and germinal center formation, but not for in vivo T cell-dependent IgM responses and T cell-independent antibody responses...
- Roles of TRAF6 in CD40 signalingBruce S Hostager
4 204 MEBRF, Department of Pediatrics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Immunol Res 39:105-14. 2007....
- Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosisJ Valladeau
Schering-Plough Laboratory for Immunological Research, Dardilly, France
J Immunol 167:5767-74. 2001..Our findings identify DC-ASGPR/human macrophage lectin as a feature of immature DC, and as another lectin important for the specialized Ag-capture function of DC...
- CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cellsPau Serra
Julia McFarlane Diabetes Research Centre, University of Calgary, Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Immunity 19:877-89. 2003..Thus, in at least some genetic backgrounds, CD154-CD40 interactions and innate stimuli release immature DCs from suppression by CD4+CD25+ T cells...
- Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in JapaneseYoshiyuki Ban
Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
Thyroid 16:443-6. 2006..Furthermore, a novel single nucleotide polymorphism (SNP) in the CD40 gene, which is located in 20q11, was found to be associated and linked with GD in Caucasians and in Koreans...
- TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activationG Cheng
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Genes Dev 10:963-73. 1996..We propose that ligand binding to CD40 or TNFR II leads to the formation of a TRAF2/TANK complex, mediating NF-kappaB activation...
- Common variants at CD40 and other loci confer risk of rheumatoid arthritisSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 40:1216-23. 2008..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
- Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responsesWilliam J Murphy
Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA
J Immunol 170:2727-33. 2003..CD40 stimulation and IL-2 may therefore be of use to promote antitumor responses in advanced metastatic cancer...
- Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE productionJ F Gauchat
Glaxo Institute for Molecular Biology, Plan les Ouates Geneva, Switzerland
FEBS Lett 315:259-66. 1993..These data suggest a the correlation between human CD40-L expression and IgE production...
- Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cellsS H Hanissian
Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
Immunity 6:379-87. 1997..These results indicate that signaling through Jak3 is activated by CD40 and plays an important role in CD40-mediated functions...
- Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10Ela Martin
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
Immunity 18:155-67. 2003..These observations have significance for autoimmune immunotherapy and suggest a mechanism by which peripheral tolerance might be constitutively maintained by RelB(-) CD40(-) DCs...
- Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cellsXugang Qiao
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Nat Immunol 7:302-10. 2006..Thus, human immunodeficiency virus 1 may evade protective T cell-dependent IgG and IgA responses by 'hijacking' physiological feedback inhibitors in B cells via Nef...
- CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cellsJian Zheng
Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
Cell Mol Immunol 7:44-50. 2010..Additionally, using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection, graft versus host disease (GVHD) and autoimmune diseases...
- T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibodyAlison L Tutt
Tenovus Research Laboratory, Cancer Sciences Division, University School of Medicine, Southampton General Hospital, Southampton, United Kingdom
J Immunol 168:2720-8. 2002..These data underline the ability of anti-CD40 mAb to potentiate CTL responses and the potency of cellular immunity in eradicating large quantities of syngeneic tumor...
- IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccinesHearn Jay Cho
Division of Hematology Medical Oncology, Department of Medicine, New York Presbyterian Hospital and Cornell Medical Center, 525 East 68th Street, New York, NY 10021
J Immunol 168:4907-13. 2002..Coordinated regulation of B7 costimulation and TAP-dependent cross-presentation results in priming of Ag-specific CD8(+) CTL, whereas CD40, B7, and IL-12 costimulation is required for priming of CD4(+) Th cells by ISS-based vaccines...
- Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challengesChe Leung Law
Department of Preclinical Therapeutics, Seattle Genetics Inc, 21823 30th Drive SE, Bothell, Washington, 98021, USA
Adv Exp Med Biol 647:8-36. 2009..This chapter reviews the role of CD40-CD40L costimulation in disease pathogenesis, the characteristics of therapeutic agents targeting this pathway and status of their clinical development...
- Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signalsA I Jaiswal
Department of Biology, University of California San Diego 92093 0063, USA
Int Immunol 8:275-85. 1996....
- CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activationDavid P Inwald
Portex, Intensive Therapy and Respiratory Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, England
Circ Res 92:1041-8. 2003..Our results support a role for CD40-mediated platelet activation in thrombosis, inflammation, and atherosclerosis...
- Upregulation of CD40--CD40 ligand system in patients with diabetes mellitusYan Jinchuan
Department of Cardiology, Affiliated Zhong Da Hospital, Southeast University Nanjing 210009, China
Clin Chim Acta 339:85-90. 2004..The purpose of this study was to assess whether CD40 system expressions were disrupted in patients with diabetes...
- Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndromeWen I Lee
Department of Pediatrics, University of Washington, School of Medicine, Children s Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, USA
Blood 105:1881-90. 2005....
- Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cellsTimothy N J Bullock
Department of Pathology and Human Immune Therapy Center, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 174:710-7. 2005....
- Hyper immunoglobulin M syndrome due to CD40 deficiency: clinical, molecular, and immunological featuresVassilios Lougaris
Department of Pediatrics, Istituto di Medicina Molecolare A Nocivelli, University of Brescia, Brescia, Italy
Immunol Rev 203:48-66. 2005..In this article, we present a comprehensive overview of the clinical, genetic, and immunological features of patients with hyper IgM syndrome due to CD40 mutations...
- Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartmentM F Liu
Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
Autoimmunity 34:107-13. 2001..We concluded that there was an intrinsic hyperexpression of CD40L on lymphoid cells within rheumatoid joints, and synovial fibroblasts could contribute to articular inflammation through surface CD40 molecule...
- Presence and maturity of dendritic cells in melanoma lymph node metastasesMarta E Polak
Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK
J Pathol 207:83-90. 2005..Immature DCs, characterized by phenotypic and morphological features, are therefore present within the tumour deposits in lymph nodes infiltrated by melanoma and may specifically modulate the anti-melanoma immune response...
- MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survivalBei Zheng
Department of Lymphoma Myeloma, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 429, Houston, TX 77030, USA
Blood 102:1019-27. 2003..These findings provide a proof-of-principle that inhibition of the MEK/ERK pathway may have therapeutic value in HD...
- Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferationJalal Ahmed-Choudhury
Liver Research Laboratories, Medical Research Council Centre for Immune Regulation, University of Birmingham Institute of Clinical Science, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
Mol Biol Cell 14:1334-45. 2003..Transient activation of NF-kappaB and sustained AP-1 activation is associated with apoptosis in hepatocytes, whereas prolonged NF-kappaB activation and a lack of AP-1 activation in IHECs result in proliferation...
- Differential expression and regulation of murine CD40 in regional vascular bedsThorsten Vowinkel
Dept of Molecular and Cellular Physiology, LSU Health Sciences Ctr, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
Am J Physiol Heart Circ Physiol 290:H631-9. 2006..Platelet- and T-lymphocyte-associated CD40L appears to play a major role in regulating the density of CD40 expression on vascular endothelial cells in vivo...
- CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL responseP Borrow
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
J Exp Med 183:2129-42. 1996..Together, the results show that CD40-CD40L interactions are required for strong antiviral humoral immune responses, and reveal a novel role for CD40L in the establishment and/or maintenance of CD8+ CTL memory...
- NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signalingS Kreuz
Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
Mol Cell Biol 21:3964-73. 2001..In conclusion, these data suggest a key role for cFLIP in the antiapoptotic response of NF-kappaB activation...
- Cross-talk between CD40 and CD40L: lessons from primary immune deficienciesSimona Ferrari
Institute of Molecular Medicine Angelo Nocivelli, Pediatrics Clinic, University of Brescia, Brescia, Italy
Curr Opin Allergy Clin Immunol 2:489-94. 2002..The purpose of this review is to provide an update of the molecular bases of CD40-mediated signalling and of the human immune defects associated with abnormalities of this activation pathway...
- Potent Monoclonal Antibody Drug ConjugatesPeter Senter; Fiscal Year: 2001..This would constitute a major advancement in the clinical treatment of cancer. ..
- CD1D-Restricted T cells and Pregnancy LossJonathan E Boyson; Fiscal Year: 2010..Completion of these aims may offer insight into the functional contributions of decidual leukocytes to pathological conditions of pregnancy. ..
- TRAF Regulation and Receptor Interactions in TNFR Family SignalsGAIL BISHOP; Fiscal Year: 2009..To explore the role of TRAF5 in B cell activation. ..
- CD40 Ligand: Therapy for Opportunistic Pathogens and HIVCARLOS SUBAUSTE; Fiscal Year: 2004..The mechanisms that mediate this effect will be elucidated. This work will provide crucial information for the evaluation of modulation of CD40L signaling as an approach to immunotherapy in HIV+ individuals. ..
- TELOMERASE AS A WIDELY EXPRESSED TUMOR ANTIGENRobert Vonderheide; Fiscal Year: 2004..Lee M. Nadler, a recognized leader in the field of tumor immunology with a strong track record for fostering the career development of physician-scientists. ..
- Enhancement of HER-2/neu-based therapy using HSP110MASOUD MANJILI; Fiscal Year: 2008..The characterization of this HSP110-HER-2/neu vaccine can be expected to define new strategies for HER-2/neu-based immunotherapy of breast cancer and to have important clinical application. ..
- The Role of ING4 in Modulating the Tumorigenic Contribution of NF-kB in GliomasETTY BENVENISTE; Fiscal Year: 2007..unreadable] [unreadable]..
- CYTOKINE REGULATION OF CIITA AND CLASS II MHC IN GLIAETTY BENVENISTE; Fiscal Year: 2004..Our studies will provide the first biological assessment of SOCS production and function in cells of the CNS, thereby setting the foundation for future therapeutic manipulations of these critical immunoregulatory proteins. ..
- CD40 Modulation of Abeta-Vaccine Immune ResponseJun Tan; Fiscal Year: 2007..abstract_text> ..
- BLyS, APRIL and antibody production in HIV infectionAndrea Cerutti; Fiscal Year: 2004..Aim 1. To analyze the mechanisms by which HIV up-regulates BLyS and APRIL in APCs. Aim 2. To analyze the role of BLyS and APRIL in the modulation of HIV-induced antibody production. ..
- HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPYHenry Murray; Fiscal Year: 2005..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
- CD40 Expression and Function in MicrogliaETTY BENVENISTE; Fiscal Year: 2007..abstract_text> ..
- Green tea derived EGCG opposes AIDS dementia-like neuronal damageJun Tan; Fiscal Year: 2008..These data should lay the foundation for further research leading to human trials in the near future. [unreadable] [unreadable] [unreadable]..
- HUCBC modulation of Alzheimer-like pathology and behavioral changesJun Tan; Fiscal Year: 2007..This knowledge is used to rationalize U-CORD-CELL" as a potentially safe and effective immunomodulatory therapy for AD. [unreadable] [unreadable] [unreadable]..
- Gene expression in non-functional CD8 T cellsSally Sarawar; Fiscal Year: 2005..The data are likely to lead to a new understanding of how CD8 T cells function in the control of persistent viral infections and mechanisms of CD8 T cell activation. ..
- REGULATION OF IL-6 EXPRESSION IN ASTROCYTESETTY BENVENISTE; Fiscal Year: 2004..The findings forthcoming from the proposed studies will provide the first biological assessment of sIL-6R production within the brain, thereby setting the foundation for futuretherapeutic manipulation of this critical soluble receptor. ..
- TRADD as a Regulator of Cytokine Signaling in GliaETTY BENVENISTE; Fiscal Year: 2009..Our studies will provide a comprehensive assessment of TRADD function in cytokine signaling, thereby advancing our understanding of this novel signaling pathway in the context of macrophage/microglial activation and neuroinflammation. ..
- FASEB SUMMER CONFERENCE ON NEUROIMMUNOLOGYETTY BENVENISTE; Fiscal Year: 2002..abstract_text> ..
- Using gene targeting to address the role of LRRK2 in Parkinson's diseaseBruce Hostager; Fiscal Year: 2007..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
- INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATIONThomas Ferguson; Fiscal Year: 2002..Finally, studies in Aim 5 will evaluate clinical specimens from patients AMD for Fas/FasL expression. Our studies should provide important insights into one of the leading causes of blindness in the western world. ..
- CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTIONSally Sarawar; Fiscal Year: 2002..3) The role of the CXCR2 chemokine receptor homologue in viral pathogenesis will be determined using a mutant virus in which the gene encoding the CXCR2 homologue has been inactivated. ..
- Mechanisms CD8 T cell mediated antimicrobial activityRoman Tuma; Fiscal Year: 2003..These studies are likely to provide valuable insights with potential implications for adoptive T cell therapy in the treatment of immunodeficiency and malignancy. ..
- Immunological control of a persistent viral infectionSally R Sarawar; Fiscal Year: 2010..The results obtained may have broader significance in understanding the mechanisms controlling T cell activation or tolerance, in general. ..
- CXCR4 Expression and Function in AstrocytesETTY BENVENISTE; Fiscal Year: 2004..The findings forthcoming from these studies will provide the first biological assessment of CXCR4 expression in the brain, thereby setting the foundation for future therapeutic manipulation of this critical chemokine receptor. ..
- ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITISAndrea Cerutti; Fiscal Year: 2003..In addition to elucidating the pathogenesis of RA, the experiments outlined in this application should allow to devise new strategies aimed at reducing the production of pathogenic antibodies, including rheumatoid factors. ..
- Composite Tissue TransplantationThomas Tung; Fiscal Year: 2006..The broad objective of this proposal is to improve the quality of reconstructive options and the quality of life for patients with devastating deformities. ..
- Host Immunoregulation of Response to Antileishmanial ChemotherapyHenry Murray; Fiscal Year: 2007..abstract_text> ..
- Interaction between influenza virus and H. influenzaeSally Sarawar; Fiscal Year: 2007..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
- T CELL THERAPY OF HUMAN RENAL CELL CANCERAlfred Chang; Fiscal Year: 2007..Lloyd Stoolman. Dr. Stoolman plans to examine novel methods to enrich tumor reactive lymphoid cells based upon adhesion marker expansion utilizing samples generated from this proposal. ..
- Molecular Mechanisms for IL-25-mediated Th2 ResponsesXiaoxia Li; Fiscal Year: 2010..With this improved understanding comes the potential to develop specific inhibitors of these pathways and perhaps novel therapeutics for the treatment of asthma. ..
- Mechanisms of CD4+CD25+ T Regulatory Cells in EAEStephen Miller; Fiscal Year: 2008..abstract_text> ..
- Mapping HIV/AIDS genes with haplotype-based strategiesRobert Plenge; Fiscal Year: 2008..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
- A Genome-Wide Association Study of Non-Hodgkin LymphomaChristine F Skibola; Fiscal Year: 2010..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
- Molecular Mechanisms of IL-1R-TLR-Mediated SignalingXiaoxia Li; Fiscal Year: 2008..The long-term objective is to develop more effective anti-inflammatory and anti-atherogenic small molecule drugs. [unreadable] [unreadable] [unreadable]..
- Identifying and Analyzing Genes Linked to Autoimmune Thyroid DiseasesYaron Tomer; Fiscal Year: 2010..This could have a major impact on public health, as it may facilitate the development of mechanism-based treatments in autoimmunity, such as CD40 blockade. ..
- Dissecting the HLA contribution to Rheumatoid ArthritisLINDSEY ANN CRISWELL; Fiscal Year: 2010..Finally, due to the clinical and apparent genetic heterogeneity of RA, we will study specific RA phenotypes as secondary outcomes. ..
- Exosomes, Dendritic Cells and Transplant ToleranceADRIAN MORELLI; Fiscal Year: 2007..AIM 3: To investigate the effect of administration of donor MHC + exosomes or recipient DCs exposed to donor MHC + exosomes on heart allograft survival. To compare the effects of donor-MHC + exosomes with donor-MHC + apoptotic cells. ..
- CD40 LIGAND IN SYSTEMIC LUPUS ERYTHEMATOSUSMARY CROW; Fiscal Year: 2002..These studies should elucidate disease pathogenesis and identify new targets for therapy in SLE. ..
- SIGNAL TRANSDUCTION BY IGM IN B LYMPHOCYTESMichel Nussenzweig; Fiscal Year: 2002..These studies have potential implications for understanding how B cells develop and produce immune responses in vivo. ..
- Immune modulation by highly virulent clinical isolates of M.tuberculosisDiane Ordway; Fiscal Year: 2009..Such information is critical to rational vaccine design. ..
- Identification of Rheumatic Disease GenesMARY CROW; Fiscal Year: 2004..abstract_text> ..
- Conference on Survival and Death in Immune TolerancePamela Ohashi; Fiscal Year: 2004..From this unique combination of perspectives, we hope to stimulate collaborations and new ideas to solve these key issues in lymphocyte biology. ..
- Induction of influenza virus-specific memory B cellsMARK SANGSTER; Fiscal Year: 2005..In addition, the systems established could be used in many other ways to address mechanistic questions related to the generation and maintenance of B cell memory. ..
- LSRII Four Laser Analytical Flow CytometerDavid Thorley Lawson; Fiscal Year: 2006..This renders the acquisition of a new LSR II essential, if we are to meet the flow cytometry needs, both in time and available technology, for the community of NIH funded researchers at TUSM and T-NEMC. [unreadable] [unreadable]..
- The role of CD4+ T cells in melanoma immunotherapyTimothy Bullock; Fiscal Year: 2006....
- Immune Defense: The Role of NKG2D/DAP10Marco Colonna; Fiscal Year: 2007..abstract_text> ..
- NEURAL CIRCUITRY OF THE KIDNEYMark Weiss; Fiscal Year: 2006..abstract_text> ..
- CNS DAMAGE FROM THEILER'S VIRUS PERSISTENCE: MS MODELStephen Miller; Fiscal Year: 2007....
- CD70 mediated costimulation of T cell responsesTimothy Bullock; Fiscal Year: 2007..abstract_text> ..
- Dendritic cell phenotype upon contact with biomaterialsJULIA BABENSEE; Fiscal Year: 2008..4) Evaluate the extent of DCs maturation in the presence of biomaterials such that they act as professional APCs in mediating an adaptive immune response to device-associated antigens. [unreadable] [unreadable]..
- TGFB1 GENE TRANSFER IN VASCULARIZED CARDIAC ALLOGRAFTSD Bishop; Fiscal Year: 2003..This study will provide insight for optimizing immunosuppressive gene therapy in clinical transplantation. ..
- B7/CD28/CTLA-4 COSTIMULATION IN PATHOGENESIS OF R-EAEStephen Miller; Fiscal Year: 2003....
- Transplantation Immunology ConferenceAngus Thomson; Fiscal Year: 2002..An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research. ..
- B cell functional and signaling abnormalities in SLEJennifer Anolik; Fiscal Year: 2006..abstract_text> ..
- REGULATION OF CD154 EXPRESSIONWILLIAM FREDERICK CARSON RIGBY; Fiscal Year: 2010..Importantly, the CD153'UTR CA repeats are polymorphic with certain alleles associated with CD154 overexpression and the development of RA and SLE. ..
- Overcoming Low HIV-1 Envelope Spike Immunogenicity By High Density DisplayStephen Dewhurst; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Platelet adhesion in experimental colitisD Granger; Fiscal Year: 2008..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. [unreadable] [unreadable] [unreadable]..
- PATHOGENESIS AND IMMUNOREGULATION OF PLP-INDUCED R-EAEStephen D Miller; Fiscal Year: 2010....
- Adaptive Immunity from High Affinity Anti-HER2/neu Monoclonal AntibodiesLouis M Weiner; Fiscal Year: 2010..A candidate antibody for clinical development will emerge, as will generally useful information regarding the structural features of antibodies that contribute to ADCC and in vivo efficacy. ..
- Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk lociRobert M Plenge; Fiscal Year: 2010..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
- The Genetic Epidemiology of RA and SLELindsey Criswell; Fiscal Year: 2005..Criswell's ability to accomplish her goals as a patient-oriented clinical researcher and mentor through the provision of essential resources and relief of patient care and other activities. ..
- MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERYDavid Pascual; Fiscal Year: 2009..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
- Monoclonal Antibody Therapy Induction of Adaptive ImmunityLouis Weiner; Fiscal Year: 2008..A candidate antibody for clinical development will emerge, as will generally useful information regarding the structural features of antibodies that contribute to ADCC and in vivo efficacy. [unreadable] [unreadable] [unreadable]..
- Mucosal Lymphocyte Homing in the Head and NeckDavid Pascual; Fiscal Year: 2008..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
- Mucosal Vaccines for PlagueDavid Pascual; Fiscal Year: 2006..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
- Microglial Cell Activation by Thrombin in StrokeJonathan Weinstein; Fiscal Year: 2008..unreadable] [unreadable]..
- TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSESDavid Pascual; Fiscal Year: 2004..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
- TESTING SLE CANDIDATE LOCI USING CASES AND THEIR PARENTSLindsey Criswell; Fiscal Year: 2003..Finally, the families recruited for this study will serve as a valuable resource for future genetic epidemiology studies of SLE. Therefore, the efforts of this project represent an important investment for the future. ..
- Novel strategies for defining the role of HLA in SLELindsey Criswell; Fiscal Year: 2009..abstract_text> ..