cd40 antigens

Summary

Summary: A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers.

Top Publications

  1. ncbi DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
  2. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
  3. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
  4. pmc TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Genes Dev 13:1015-24. 1999
  5. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
  6. ncbi A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Christine Bourgeois
    INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
    Science 297:2060-3. 2002
  7. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
  8. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
  9. ncbi TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
    M Rothe
    Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
    Science 269:1424-7. 1995
  10. ncbi Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998

Detail Information

Publications262 found, 100 shown here

  1. ncbi DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
    ..By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses...
  2. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation...
  3. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
    ....
  4. pmc TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Genes Dev 13:1015-24. 1999
    ..These findings establish unexpectedly diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling...
  5. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ....
  6. ncbi A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Christine Bourgeois
    INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
    Science 297:2060-3. 2002
    ..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
  7. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    ..Our results indicate that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall...
  8. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    ..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
  9. ncbi TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
    M Rothe
    Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
    Science 269:1424-7. 1995
    ..A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant-negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD40. Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling...
  10. ncbi Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998
    ..These data support the involvement of inflammatory pathways in atherosclerosis and indicate a role for CD40 signalling during atherogenesis in hyperlipidaemic mice...
  11. ncbi Endotoxin-induced maturation of MyD88-deficient dendritic cells
    T Kaisho
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 166:5688-94. 2001
    ..Collectively, the present study provides the first evidence that the MyD88-independent pathway downstream of TLR4 can lead to functional DC maturation, which is critical for a link between innate and adaptive immunity...
  12. ncbi Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8
    Mariola Fotin-Mleczek
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Cell Sci 115:2757-70. 2002
    ..Hence, TNF-R2 triggering can interfere with TNF-R1-induced apoptosis by inhibition of NF-kappaB-dependent production of anti-apoptotic factors and by blocking the action of anti-apoptotic factors at the post-transcriptional level...
  13. ncbi Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
    I S Grewal
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 378:617-20. 1995
    ....
  14. pmc Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    U Schonbeck
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7458-63. 2000
    ..This study lends further support to the importance of this specific inflammatory signaling pathway in atherosclerosis and its complications...
  15. pmc TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
    T K Ishida
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:9437-42. 1996
    ..These results suggest that TRAF5 and TRAF3 could be involved in both common and distinct signaling pathways emanating from CD40...
  16. ncbi Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo
    Douglas G Millar
    Departments of Immunology and Medical Biophysics, University Health Network, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
    Nat Med 9:1469-76. 2003
    ..In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo...
  17. ncbi CD40 and dendritic cell function
    Brendan O'Sullivan
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland 4102, Australia
    Crit Rev Immunol 23:83-107. 2003
    ..CD40 may also play an important role in the decision between tolerance and immunity and the generation of regulatory CD4+ T cells that are thought to maintain peripheral self-tolerance in vivo...
  18. ncbi A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology
    Eric M Jacobson
    Division of Endocrinology, Box 1055, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Endocrinology 146:2684-91. 2005
    ..Therefore, our results may suggest that the C allele of the CD40 Kozak SNP, which is associated with Graves' disease, could predispose to disease by increasing the efficiency of translation of CD40 mRNA...
  19. ncbi Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells
    M L Albert
    Laboratory of Neuro Oncology, The Rockefeller University, 1230 York Avenue, Box 26, New York, NY 10021, USA
    Nat Immunol 2:1010-7. 2001
    ....
  20. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  21. pmc CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression
    K Karmann
    Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 92:4342-6. 1995
    ..CD40 may be detected immunocytochemically on human microvascular EC in normal skin. We conclude that endothelial CD40 may play a role as a signaling receptor in the development of T-cell-mediated inflammatory reactions...
  22. pmc Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation
    Lelia Delamarre
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520 8002, USA
    J Exp Med 198:111-22. 2003
    ..Thus, the MHC I and MHC II pathways of antigen presentation are differentially regulated during DC maturation...
  23. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  24. ncbi The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
    A Aruffo
    Bristol Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121
    Cell 72:291-300. 1993
    ..The gene encoding gp39 was mapped to Xq26, the X chromosome region where the gene responsible for HIM had previously been mapped. These data suggest that a defect in gp39 is the basis of X-linked HIM...
  25. ncbi TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses
    L T Nguyen
    Department of Immunology, University of Toronto, Ontario, Canada
    Immunity 11:379-89. 1999
    ..These data demonstrate two important roles of TRAF2, one as a negative regulator of certain TNFR1 signals and the other as a positive mediator of CD40 signaling...
  26. ncbi Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity
    Xinan Jiao
    Unité de Biologie des Régulations Immunitaires, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Immunol 168:1294-301. 2002
    ..Strikingly, BCG bacilli survive but remain stable in number in the DC leukocyte subset during the first 2 wk of infection. As Ag presentation by DC is rapidly lost, this suggests that DC may represent a hidden reservoir for mycobacteria...
  27. pmc Short-circuiting long-lived humoral immunity by the heightened engagement of CD40
    Loren D Erickson
    Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Clin Invest 109:613-20. 2002
    ..These are the first studies to describe the multifaceted function of CD40 in determining the fate of antigen-reactive B cells and provide novel insights into how CD40 agonists can short-circuit humoral immunity...
  28. ncbi RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy
    Christina M Coughlin
    Division of Hematology and Oncology, Children s Hospital of Philadelphia, and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 19104, USA
    Blood 103:2046-54. 2004
    ..These findings support a novel platform for tumor-specific vaccine or adoptive immunotherapies in pediatric malignancies...
  29. pmc TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
    M F Bachmann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 189:1025-31. 1999
    ..Moreover, the data suggest that TRANCE/TRANCE-R may be a novel and important target for immune intervention...
  30. ncbi The multi-functionality of CD40L and its receptor CD40 in atherosclerosis
    Dirk Lievens
    Department of Pathology, University of Maastricht, 6229 HX Maastricht, The Netherlands
    Thromb Haemost 102:206-14. 2009
    ..In this review, we highlight the cell-type specific multi-functionality of CD40-CD40L signalling in atherosclerosis...
  31. pmc Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    Jonathan J Keats
    Comprehensive Cancer Center, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Cancer Cell 12:131-44. 2007
    ..These results highlight the critical importance of the NF-kappaB pathway in the pathogenesis of multiple myeloma...
  32. pmc Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis
    F Mach
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:1931-6. 1997
    ....
  33. ncbi CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
    R C Allen
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 259:990-3. 1993
    ..Thus, these CD40L defects lead to a T cell abnormality that results in the failure of patient B cells to undergo immunoglobulin class switching...
  34. ncbi The CD40/CD154 receptor/ligand dyad
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:4-43. 2001
    ....
  35. ncbi TRAF proteins in CD40 signaling
    Gail A Bishop
    Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa and the Iowa City VAMC, Iowa City, Iowa 52242, USA
    Adv Exp Med Biol 597:131-51. 2007
    ..This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions...
  36. pmc CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
    Giandomenica Iezzi
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:876-81. 2009
    ..Our data demonstrate that CD40-CD40L cross-talk is important for Th17 development by translating strong T cell receptor and microbial stimuli into IL-6 production...
  37. ncbi Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
  38. pmc CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cells
    Y Zhang
    Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 74:8003-10. 2000
    ....
  39. pmc CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    Mol Cell Biol 20:5503-15. 2000
    ..These findings identify a novel proapoptotic mechanism which is induced by CD40 in carcinoma cells and depends on the endogenous production of cytotoxic cytokines and autocrine or paracrine induction of cell death...
  40. ncbi CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines
    Y Wang
    Peter Gorer Department of Immunobiology, Guy's, King's, and St. Thomas' Medical School, KCL, London, United Kingdom
    Immunity 15:971-83. 2001
    ..Coimmunoprecipitation of Mtb HSP70 with CD40 indicates a physical association between these molecules. The results suggest that CD40 is critical in microbial HSP70 binding and stimulation of RANTES production...
  41. ncbi Functions of CD40 on B cells, dendritic cells and other cells
    C van Kooten
    Department of Nephrology, Leiden University Hospital, 1 C3P, Albinusdreef 2, 2333 AA, Leiden, The Netherlands
    Curr Opin Immunol 9:330-7. 1997
    ..Finally, the critical role of CD40-CD40L interactions in the development of various disease states has been fully appreciated...
  42. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    ....
  43. pmc Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Exp Med 199:661-71. 2004
    ..Our data reveal that CD40 and LMP1 unexpectedly use TRAF3 in different ways, and that TRAF3 is required for LMP1-mediated activation of B cells...
  44. pmc Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
    F Rousset
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    Proc Natl Acad Sci U S A 89:1890-3. 1992
    ..Thus, IL-10 may play an important role in the amplification of humoral responses...
  45. pmc Crystallographic analysis of CD40 recognition and signaling by human TRAF2
    S M McWhirter
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3206, USA
    Proc Natl Acad Sci U S A 96:8408-13. 1999
    ..The spacing between the CD40 binding sites on TRAF2 supports an elegant signaling mechanism in which trimeric, extracellular ligands preorganize the receptors to simultaneously recognize three sites on the TRAF trimer...
  46. ncbi Multiple roles of TRAF3 signaling in lymphocyte function
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Res 39:22-32. 2007
    ..TRAF3 is also important for signaling via innate immune receptors, as well as an oncogenic mimic of a normal receptor that is implicated in promoting both malignancies and autoimmunity...
  47. ncbi Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administration
    Kristin Hochweller
    ICAPB, University of Edinburgh, Edinburgh, GB
    Eur J Immunol 34:990-8. 2004
    ..These data implicate the CD40:CD40L interaction as a key checkpoint in the development of T cell immunity rather than tolerance...
  48. pmc NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
    H H Lee
    Department of Microbiology and Molecular Genetics, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:9136-41. 1999
    ..Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members...
  49. ncbi DC-NK cell cross talk as a novel CD4+ T-cell-independent pathway for antitumor CTL induction
    Christian Adam
    GSF Institut für Molekulare Immunologie, Marchioninistr 25, D 81377 Munchen, Germany
    Blood 106:338-44. 2005
    ..This pathway was dependent on inter-feron-gamma expression and involved priming endogenous DCs for interleukin-12 production. Our data suggest a novel pathway linking innate and adaptive immunity...
  50. pmc CD40 and autoimmunity: the dark side of a great activator
    Anna L Peters
    Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Semin Immunol 21:293-300. 2009
    ..This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy...
  51. ncbi Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes
    Gail A Bishop
    Department of Microbiology, 3 570 Bowen Science Building, The University of Iowa, Iowa City, IA 52242, USA
    J Leukoc Biol 72:19-23. 2002
    ..For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview...
  52. ncbi Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
    L Soong
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Immunity 4:263-73. 1996
    ..These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite...
  53. ncbi Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses
    L Boon
    Tanox Pharma B.V, Amsterdam, The Netherlands
    J Immunol 167:2942-9. 2001
    ....
  54. pmc T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation
    Simon Fillatreau
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 197:195-206. 2003
    ..Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice...
  55. ncbi Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Immunol 183:3742-50. 2009
    ..This approach may facilitate the clinical application of CD8(+) Treg-based immunotherapy in transplantation and autoimmune diseases...
  56. ncbi The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity
    S R Clarke
    Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle 98195 7370, USA
    J Leukoc Biol 67:607-14. 2000
    ..It is important that CD40 and its ligand, CD40L, have been implicated in the provision of this help and, in particular, the generation of long-lasting CTL memory...
  57. pmc Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
    K D Brown
    Medical Scientist Training Program, University of Iowa, Iowa City 52242, USA
    J Exp Med 193:943-54. 2001
    ..This suggests that LMP1 utilizes a modified CD40 signaling pathway. Failure to regulate TRAFs may contribute to the enhanced capacity of LMP1 to activate B cells as well as promote B cell transformation...
  58. ncbi Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications
    Yu Tzu Tai
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 65:11712-20. 2005
    ....
  59. ncbi IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells
    S Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:90-7. 2001
    ..These observations indicate that IL-1 enhances T cell-dependent Ab production by augmenting CD40 ligand and OX40 expression on T cells...
  60. ncbi ICOS is critical for CD40-mediated antibody class switching
    A J McAdam
    Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 409:102-5. 2001
    ..Class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway...
  61. ncbi Potent adjuvant effect by anti-CD40 in collagen-induced arthritis. Enhanced disease is accompanied by increased production of collagen type-II reactive IgG2a and IFN-gamma
    A C Tellander
    Active Biotech Research AB, Lund, Sweden
    J Autoimmun 14:295-302. 2000
    ..In conclusion, our results indicate that the level of CD40 activation during the induction of an autoimmune response may determine the severity of the resulting disease...
  62. ncbi CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    S S Pullen
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    Biochemistry 37:11836-45. 1998
    ..Relative affinities and competition of individual and hetero-oligomeric TRAF proteins for CD40 binding sites may contribute to receptor specificity and cell-type selectivity in CD40-dependent signaling...
  63. ncbi Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
    Che Leung Law
    Seattle Genetics, Inc, Bothell, Washington 98021, USA
    Cancer Res 65:8331-8. 2005
    ..The preclinical in vitro and in vivo antilymphoma activity of SGN-40 observed in this study provides a rationale for the clinical testing of SGN-40 in the treatment of CD40+ B-lineage lymphomas...
  64. pmc CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants
    Michael von Bergwelt-Baildon
    Molecular Tumor Biology and Tumor Immunology, Clinic I of Internal Medicine, Hematology Oncology, Kerpener Str 62, 50924 Köln, Germany
    Blood 107:2786-9. 2006
    ..Furthermore, we show that CD40-B cells express important T-cell attractants and induce strong T-cell chemotaxis. These findings further support the use of CD40-B cells as cellular adjuvant for cancer immunotherapy...
  65. ncbi Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 151:706-11. 2006
    ..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion...
  66. ncbi Inhibitory effects of B cells on antitumor immunity
    Satoshi Inoue
    Center for Biologics Evaluation and Research, Division of Hematology, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    Cancer Res 66:7741-7. 2006
    ..Our studies provide the first mechanistic basis for the concept that B-cell depletion could therapeutically enhance antitumor immune responses to certain tumors by decreasing IL-10 production from B cells...
  67. ncbi Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 26:812-26. 2007
    ..Thus, mucosal vaccines should activate IECs to induce more effective IgA(2) responses...
  68. ncbi Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    Robert H Vonderheide
    Abramson Family Cancer Research Institute, Abramson Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Oncol 25:876-83. 2007
    ..CD40 is also expressed by solid tumors, but its engagement results in apoptosis. CP-870,893, a fully human and selective CD40 agonist monoclonal antibody (mAb), was tested for safety in a phase I dose-escalation study...
  69. ncbi CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP
    Mekhine Baccam
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:3099-108. 2003
    ..Furthermore, CD40 stimulation led to phosphorylation of c-Jun on its activation domain, implicating CD40-mediated Jun kinase activation in the transcriptional regulation of IL-6 production...
  70. ncbi Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions
    A J Miga
    Department of Microbiology, Dartmouth Medical School, Lebanon, USA
    Eur J Immunol 31:959-65. 2001
    ..Hence, the profound impact of CD154 deficiency on cell-mediated immunity may be due to its ability to limit the duration of antigen presentation in vivo and cause the premature demise of antigen-specific T cells...
  71. ncbi CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration
    Jon D Vogel
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western University School of Medicine, Cleveland, OH 44106, USA
    Gastroenterology 126:63-80. 2004
    ....
  72. ncbi The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation
    T Kawabe
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Immunity 1:167-78. 1994
    ..These results suggest that CD40 is essential for T cell-dependent immunoglobulin class switching and germinal center formation, but not for in vivo T cell-dependent IgM responses and T cell-independent antibody responses...
  73. ncbi Roles of TRAF6 in CD40 signaling
    Bruce S Hostager
    4 204 MEBRF, Department of Pediatrics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Immunol Res 39:105-14. 2007
    ....
  74. ncbi Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis
    J Valladeau
    Schering-Plough Laboratory for Immunological Research, Dardilly, France
    J Immunol 167:5767-74. 2001
    ..Our findings identify DC-ASGPR/human macrophage lectin as a feature of immature DC, and as another lectin important for the specialized Ag-capture function of DC...
  75. ncbi CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells
    Pau Serra
    Julia McFarlane Diabetes Research Centre, University of Calgary, Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Immunity 19:877-89. 2003
    ..Thus, in at least some genetic backgrounds, CD154-CD40 interactions and innate stimuli release immature DCs from suppression by CD4+CD25+ T cells...
  76. ncbi Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese
    Yoshiyuki Ban
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Thyroid 16:443-6. 2006
    ..Furthermore, a novel single nucleotide polymorphism (SNP) in the CD40 gene, which is located in 20q11, was found to be associated and linked with GD in Caucasians and in Koreans...
  77. ncbi TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation
    G Cheng
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 10:963-73. 1996
    ..We propose that ligand binding to CD40 or TNFR II leads to the formation of a TRAF2/TANK complex, mediating NF-kappaB activation...
  78. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  79. ncbi Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses
    William J Murphy
    Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Immunol 170:2727-33. 2003
    ..CD40 stimulation and IL-2 may therefore be of use to promote antitumor responses in advanced metastatic cancer...
  80. ncbi Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production
    J F Gauchat
    Glaxo Institute for Molecular Biology, Plan les Ouates Geneva, Switzerland
    FEBS Lett 315:259-66. 1993
    ..These data suggest a the correlation between human CD40-L expression and IgE production...
  81. ncbi Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
    S H Hanissian
    Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 6:379-87. 1997
    ..These results indicate that signaling through Jak3 is activated by CD40 and plays an important role in CD40-mediated functions...
  82. ncbi Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10
    Ela Martin
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    Immunity 18:155-67. 2003
    ..These observations have significance for autoimmune immunotherapy and suggest a mechanism by which peripheral tolerance might be constitutively maintained by RelB(-) CD40(-) DCs...
  83. ncbi Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells
    Xugang Qiao
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Immunol 7:302-10. 2006
    ..Thus, human immunodeficiency virus 1 may evade protective T cell-dependent IgG and IgA responses by 'hijacking' physiological feedback inhibitors in B cells via Nef...
  84. pmc CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cell Mol Immunol 7:44-50. 2010
    ..Additionally, using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection, graft versus host disease (GVHD) and autoimmune diseases...
  85. ncbi T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody
    Alison L Tutt
    Tenovus Research Laboratory, Cancer Sciences Division, University School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 168:2720-8. 2002
    ..These data underline the ability of anti-CD40 mAb to potentiate CTL responses and the potency of cellular immunity in eradicating large quantities of syngeneic tumor...
  86. ncbi IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines
    Hearn Jay Cho
    Division of Hematology Medical Oncology, Department of Medicine, New York Presbyterian Hospital and Cornell Medical Center, 525 East 68th Street, New York, NY 10021
    J Immunol 168:4907-13. 2002
    ..Coordinated regulation of B7 costimulation and TAP-dependent cross-presentation results in priming of Ag-specific CD8(+) CTL, whereas CD40, B7, and IL-12 costimulation is required for priming of CD4(+) Th cells by ISS-based vaccines...
  87. ncbi Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges
    Che Leung Law
    Department of Preclinical Therapeutics, Seattle Genetics Inc, 21823 30th Drive SE, Bothell, Washington, 98021, USA
    Adv Exp Med Biol 647:8-36. 2009
    ..This chapter reviews the role of CD40-CD40L costimulation in disease pathogenesis, the characteristics of therapeutic agents targeting this pathway and status of their clinical development...
  88. ncbi Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals
    A I Jaiswal
    Department of Biology, University of California San Diego 92093 0063, USA
    Int Immunol 8:275-85. 1996
    ....
  89. ncbi CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation
    David P Inwald
    Portex, Intensive Therapy and Respiratory Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, England
    Circ Res 92:1041-8. 2003
    ..Our results support a role for CD40-mediated platelet activation in thrombosis, inflammation, and atherosclerosis...
  90. ncbi Upregulation of CD40--CD40 ligand system in patients with diabetes mellitus
    Yan Jinchuan
    Department of Cardiology, Affiliated Zhong Da Hospital, Southeast University Nanjing 210009, China
    Clin Chim Acta 339:85-90. 2004
    ..The purpose of this study was to assess whether CD40 system expressions were disrupted in patients with diabetes...
  91. ncbi Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome
    Wen I Lee
    Department of Pediatrics, University of Washington, School of Medicine, Children s Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, USA
    Blood 105:1881-90. 2005
    ....
  92. ncbi Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells
    Timothy N J Bullock
    Department of Pathology and Human Immune Therapy Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 174:710-7. 2005
    ....
  93. ncbi Hyper immunoglobulin M syndrome due to CD40 deficiency: clinical, molecular, and immunological features
    Vassilios Lougaris
    Department of Pediatrics, Istituto di Medicina Molecolare A Nocivelli, University of Brescia, Brescia, Italy
    Immunol Rev 203:48-66. 2005
    ..In this article, we present a comprehensive overview of the clinical, genetic, and immunological features of patients with hyper IgM syndrome due to CD40 mutations...
  94. ncbi Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment
    M F Liu
    Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
    Autoimmunity 34:107-13. 2001
    ..We concluded that there was an intrinsic hyperexpression of CD40L on lymphoid cells within rheumatoid joints, and synovial fibroblasts could contribute to articular inflammation through surface CD40 molecule...
  95. ncbi Presence and maturity of dendritic cells in melanoma lymph node metastases
    Marta E Polak
    Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK
    J Pathol 207:83-90. 2005
    ..Immature DCs, characterized by phenotypic and morphological features, are therefore present within the tumour deposits in lymph nodes infiltrated by melanoma and may specifically modulate the anti-melanoma immune response...
  96. ncbi MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival
    Bei Zheng
    Department of Lymphoma Myeloma, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 429, Houston, TX 77030, USA
    Blood 102:1019-27. 2003
    ..These findings provide a proof-of-principle that inhibition of the MEK/ERK pathway may have therapeutic value in HD...
  97. pmc Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation
    Jalal Ahmed-Choudhury
    Liver Research Laboratories, Medical Research Council Centre for Immune Regulation, University of Birmingham Institute of Clinical Science, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    Mol Biol Cell 14:1334-45. 2003
    ..Transient activation of NF-kappaB and sustained AP-1 activation is associated with apoptosis in hepatocytes, whereas prolonged NF-kappaB activation and a lack of AP-1 activation in IHECs result in proliferation...
  98. ncbi Differential expression and regulation of murine CD40 in regional vascular beds
    Thorsten Vowinkel
    Dept of Molecular and Cellular Physiology, LSU Health Sciences Ctr, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
    Am J Physiol Heart Circ Physiol 290:H631-9. 2006
    ..Platelet- and T-lymphocyte-associated CD40L appears to play a major role in regulating the density of CD40 expression on vascular endothelial cells in vivo...
  99. pmc CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response
    P Borrow
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 183:2129-42. 1996
    ..Together, the results show that CD40-CD40L interactions are required for strong antiviral humoral immune responses, and reveal a novel role for CD40L in the establishment and/or maintenance of CD8+ CTL memory...
  100. pmc NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    S Kreuz
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    Mol Cell Biol 21:3964-73. 2001
    ..In conclusion, these data suggest a key role for cFLIP in the antiapoptotic response of NF-kappaB activation...
  101. ncbi Cross-talk between CD40 and CD40L: lessons from primary immune deficiencies
    Simona Ferrari
    Institute of Molecular Medicine Angelo Nocivelli, Pediatrics Clinic, University of Brescia, Brescia, Italy
    Curr Opin Allergy Clin Immunol 2:489-94. 2002
    ..The purpose of this review is to provide an update of the molecular bases of CD40-mediated signalling and of the human immune defects associated with abnormalities of this activation pathway...

Research Grants69

  1. Potent Monoclonal Antibody Drug Conjugates
    Peter Senter; Fiscal Year: 2001
    ..This would constitute a major advancement in the clinical treatment of cancer. ..
  2. CD1D-Restricted T cells and Pregnancy Loss
    Jonathan E Boyson; Fiscal Year: 2010
    ..Completion of these aims may offer insight into the functional contributions of decidual leukocytes to pathological conditions of pregnancy. ..
  3. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2009
    ..To explore the role of TRAF5 in B cell activation. ..
  4. CD40 Ligand: Therapy for Opportunistic Pathogens and HIV
    CARLOS SUBAUSTE; Fiscal Year: 2004
    ..The mechanisms that mediate this effect will be elucidated. This work will provide crucial information for the evaluation of modulation of CD40L signaling as an approach to immunotherapy in HIV+ individuals. ..
  5. TELOMERASE AS A WIDELY EXPRESSED TUMOR ANTIGEN
    Robert Vonderheide; Fiscal Year: 2004
    ..Lee M. Nadler, a recognized leader in the field of tumor immunology with a strong track record for fostering the career development of physician-scientists. ..
  6. Enhancement of HER-2/neu-based therapy using HSP110
    MASOUD MANJILI; Fiscal Year: 2008
    ..The characterization of this HSP110-HER-2/neu vaccine can be expected to define new strategies for HER-2/neu-based immunotherapy of breast cancer and to have important clinical application. ..
  7. The Role of ING4 in Modulating the Tumorigenic Contribution of NF-kB in Gliomas
    ETTY BENVENISTE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. CYTOKINE REGULATION OF CIITA AND CLASS II MHC IN GLIA
    ETTY BENVENISTE; Fiscal Year: 2004
    ..Our studies will provide the first biological assessment of SOCS production and function in cells of the CNS, thereby setting the foundation for future therapeutic manipulations of these critical immunoregulatory proteins. ..
  9. CD40 Modulation of Abeta-Vaccine Immune Response
    Jun Tan; Fiscal Year: 2007
    ..abstract_text> ..
  10. BLyS, APRIL and antibody production in HIV infection
    Andrea Cerutti; Fiscal Year: 2004
    ..Aim 1. To analyze the mechanisms by which HIV up-regulates BLyS and APRIL in APCs. Aim 2. To analyze the role of BLyS and APRIL in the modulation of HIV-induced antibody production. ..
  11. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  12. CD40 Expression and Function in Microglia
    ETTY BENVENISTE; Fiscal Year: 2007
    ..abstract_text> ..
  13. Green tea derived EGCG opposes AIDS dementia-like neuronal damage
    Jun Tan; Fiscal Year: 2008
    ..These data should lay the foundation for further research leading to human trials in the near future. [unreadable] [unreadable] [unreadable]..
  14. HUCBC modulation of Alzheimer-like pathology and behavioral changes
    Jun Tan; Fiscal Year: 2007
    ..This knowledge is used to rationalize U-CORD-CELL" as a potentially safe and effective immunomodulatory therapy for AD. [unreadable] [unreadable] [unreadable]..
  15. Gene expression in non-functional CD8 T cells
    Sally Sarawar; Fiscal Year: 2005
    ..The data are likely to lead to a new understanding of how CD8 T cells function in the control of persistent viral infections and mechanisms of CD8 T cell activation. ..
  16. REGULATION OF IL-6 EXPRESSION IN ASTROCYTES
    ETTY BENVENISTE; Fiscal Year: 2004
    ..The findings forthcoming from the proposed studies will provide the first biological assessment of sIL-6R production within the brain, thereby setting the foundation for futuretherapeutic manipulation of this critical soluble receptor. ..
  17. TRADD as a Regulator of Cytokine Signaling in Glia
    ETTY BENVENISTE; Fiscal Year: 2009
    ..Our studies will provide a comprehensive assessment of TRADD function in cytokine signaling, thereby advancing our understanding of this novel signaling pathway in the context of macrophage/microglial activation and neuroinflammation. ..
  18. FASEB SUMMER CONFERENCE ON NEUROIMMUNOLOGY
    ETTY BENVENISTE; Fiscal Year: 2002
    ..abstract_text> ..
  19. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
  20. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..Finally, studies in Aim 5 will evaluate clinical specimens from patients AMD for Fas/FasL expression. Our studies should provide important insights into one of the leading causes of blindness in the western world. ..
  21. CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTION
    Sally Sarawar; Fiscal Year: 2002
    ..3) The role of the CXCR2 chemokine receptor homologue in viral pathogenesis will be determined using a mutant virus in which the gene encoding the CXCR2 homologue has been inactivated. ..
  22. Mechanisms CD8 T cell mediated antimicrobial activity
    Roman Tuma; Fiscal Year: 2003
    ..These studies are likely to provide valuable insights with potential implications for adoptive T cell therapy in the treatment of immunodeficiency and malignancy. ..
  23. Immunological control of a persistent viral infection
    Sally R Sarawar; Fiscal Year: 2010
    ..The results obtained may have broader significance in understanding the mechanisms controlling T cell activation or tolerance, in general. ..
  24. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2004
    ..The findings forthcoming from these studies will provide the first biological assessment of CXCR4 expression in the brain, thereby setting the foundation for future therapeutic manipulation of this critical chemokine receptor. ..
  25. ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Andrea Cerutti; Fiscal Year: 2003
    ..In addition to elucidating the pathogenesis of RA, the experiments outlined in this application should allow to devise new strategies aimed at reducing the production of pathogenic antibodies, including rheumatoid factors. ..
  26. Composite Tissue Transplantation
    Thomas Tung; Fiscal Year: 2006
    ..The broad objective of this proposal is to improve the quality of reconstructive options and the quality of life for patients with devastating deformities. ..
  27. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  28. Interaction between influenza virus and H. influenzae
    Sally Sarawar; Fiscal Year: 2007
    ..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
  29. T CELL THERAPY OF HUMAN RENAL CELL CANCER
    Alfred Chang; Fiscal Year: 2007
    ..Lloyd Stoolman. Dr. Stoolman plans to examine novel methods to enrich tumor reactive lymphoid cells based upon adhesion marker expansion utilizing samples generated from this proposal. ..
  30. Molecular Mechanisms for IL-25-mediated Th2 Responses
    Xiaoxia Li; Fiscal Year: 2010
    ..With this improved understanding comes the potential to develop specific inhibitors of these pathways and perhaps novel therapeutics for the treatment of asthma. ..
  31. Mechanisms of CD4+CD25+ T Regulatory Cells in EAE
    Stephen Miller; Fiscal Year: 2008
    ..abstract_text> ..
  32. Mapping HIV/AIDS genes with haplotype-based strategies
    Robert Plenge; Fiscal Year: 2008
    ..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
  33. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  34. Molecular Mechanisms of IL-1R-TLR-Mediated Signaling
    Xiaoxia Li; Fiscal Year: 2008
    ..The long-term objective is to develop more effective anti-inflammatory and anti-atherogenic small molecule drugs. [unreadable] [unreadable] [unreadable]..
  35. Identifying and Analyzing Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2010
    ..This could have a major impact on public health, as it may facilitate the development of mechanism-based treatments in autoimmunity, such as CD40 blockade. ..
  36. Dissecting the HLA contribution to Rheumatoid Arthritis
    LINDSEY ANN CRISWELL; Fiscal Year: 2010
    ..Finally, due to the clinical and apparent genetic heterogeneity of RA, we will study specific RA phenotypes as secondary outcomes. ..
  37. Exosomes, Dendritic Cells and Transplant Tolerance
    ADRIAN MORELLI; Fiscal Year: 2007
    ..AIM 3: To investigate the effect of administration of donor MHC + exosomes or recipient DCs exposed to donor MHC + exosomes on heart allograft survival. To compare the effects of donor-MHC + exosomes with donor-MHC + apoptotic cells. ..
  38. CD40 LIGAND IN SYSTEMIC LUPUS ERYTHEMATOSUS
    MARY CROW; Fiscal Year: 2002
    ..These studies should elucidate disease pathogenesis and identify new targets for therapy in SLE. ..
  39. SIGNAL TRANSDUCTION BY IGM IN B LYMPHOCYTES
    Michel Nussenzweig; Fiscal Year: 2002
    ..These studies have potential implications for understanding how B cells develop and produce immune responses in vivo. ..
  40. Immune modulation by highly virulent clinical isolates of M.tuberculosis
    Diane Ordway; Fiscal Year: 2009
    ..Such information is critical to rational vaccine design. ..
  41. Identification of Rheumatic Disease Genes
    MARY CROW; Fiscal Year: 2004
    ..abstract_text> ..
  42. Conference on Survival and Death in Immune Tolerance
    Pamela Ohashi; Fiscal Year: 2004
    ..From this unique combination of perspectives, we hope to stimulate collaborations and new ideas to solve these key issues in lymphocyte biology. ..
  43. Induction of influenza virus-specific memory B cells
    MARK SANGSTER; Fiscal Year: 2005
    ..In addition, the systems established could be used in many other ways to address mechanistic questions related to the generation and maintenance of B cell memory. ..
  44. LSRII Four Laser Analytical Flow Cytometer
    David Thorley Lawson; Fiscal Year: 2006
    ..This renders the acquisition of a new LSR II essential, if we are to meet the flow cytometry needs, both in time and available technology, for the community of NIH funded researchers at TUSM and T-NEMC. [unreadable] [unreadable]..
  45. The role of CD4+ T cells in melanoma immunotherapy
    Timothy Bullock; Fiscal Year: 2006
    ....
  46. Immune Defense: The Role of NKG2D/DAP10
    Marco Colonna; Fiscal Year: 2007
    ..abstract_text> ..
  47. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006
    ..abstract_text> ..
  48. CNS DAMAGE FROM THEILER'S VIRUS PERSISTENCE: MS MODEL
    Stephen Miller; Fiscal Year: 2007
    ....
  49. CD70 mediated costimulation of T cell responses
    Timothy Bullock; Fiscal Year: 2007
    ..abstract_text> ..
  50. Dendritic cell phenotype upon contact with biomaterials
    JULIA BABENSEE; Fiscal Year: 2008
    ..4) Evaluate the extent of DCs maturation in the presence of biomaterials such that they act as professional APCs in mediating an adaptive immune response to device-associated antigens. [unreadable] [unreadable]..
  51. TGFB1 GENE TRANSFER IN VASCULARIZED CARDIAC ALLOGRAFTS
    D Bishop; Fiscal Year: 2003
    ..This study will provide insight for optimizing immunosuppressive gene therapy in clinical transplantation. ..
  52. B7/CD28/CTLA-4 COSTIMULATION IN PATHOGENESIS OF R-EAE
    Stephen Miller; Fiscal Year: 2003
    ....
  53. Transplantation Immunology Conference
    Angus Thomson; Fiscal Year: 2002
    ..An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research. ..
  54. B cell functional and signaling abnormalities in SLE
    Jennifer Anolik; Fiscal Year: 2006
    ..abstract_text> ..
  55. REGULATION OF CD154 EXPRESSION
    WILLIAM FREDERICK CARSON RIGBY; Fiscal Year: 2010
    ..Importantly, the CD153'UTR CA repeats are polymorphic with certain alleles associated with CD154 overexpression and the development of RA and SLE. ..
  56. Overcoming Low HIV-1 Envelope Spike Immunogenicity By High Density Display
    Stephen Dewhurst; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2008
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. [unreadable] [unreadable] [unreadable]..
  58. PATHOGENESIS AND IMMUNOREGULATION OF PLP-INDUCED R-EAE
    Stephen D Miller; Fiscal Year: 2010
    ....
  59. Adaptive Immunity from High Affinity Anti-HER2/neu Monoclonal Antibodies
    Louis M Weiner; Fiscal Year: 2010
    ..A candidate antibody for clinical development will emerge, as will generally useful information regarding the structural features of antibodies that contribute to ADCC and in vivo efficacy. ..
  60. Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk loci
    Robert M Plenge; Fiscal Year: 2010
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  61. The Genetic Epidemiology of RA and SLE
    Lindsey Criswell; Fiscal Year: 2005
    ..Criswell's ability to accomplish her goals as a patient-oriented clinical researcher and mentor through the provision of essential resources and relief of patient care and other activities. ..
  62. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  63. Monoclonal Antibody Therapy Induction of Adaptive Immunity
    Louis Weiner; Fiscal Year: 2008
    ..A candidate antibody for clinical development will emerge, as will generally useful information regarding the structural features of antibodies that contribute to ADCC and in vivo efficacy. [unreadable] [unreadable] [unreadable]..
  64. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2008
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  65. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
    ..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
  66. Microglial Cell Activation by Thrombin in Stroke
    Jonathan Weinstein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  67. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  68. TESTING SLE CANDIDATE LOCI USING CASES AND THEIR PARENTS
    Lindsey Criswell; Fiscal Year: 2003
    ..Finally, the families recruited for this study will serve as a valuable resource for future genetic epidemiology studies of SLE. Therefore, the efforts of this project represent an important investment for the future. ..
  69. Novel strategies for defining the role of HLA in SLE
    Lindsey Criswell; Fiscal Year: 2009
    ..abstract_text> ..