cd3 antigens

Summary

Summary: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

Top Publications

  1. pmc Targeted adenovirus-mediated gene delivery to T cells via CD3
    T J Wickham
    GenVec, Inc, Rockville, Maryland 20852 1709, USA
    J Virol 71:7663-9. 1997
  2. ncbi Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes
    David A Zapata
    Inmunologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 279:24485-92. 2004
  3. ncbi Innate immune functions of human gammadelta T cells
    Susann Beetz
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstrasse 5, D 24105 Kiel, Germany
    Immunobiology 213:173-82. 2008
  4. ncbi Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
    A Löffler
    Department of Haematology, Oncology and Tumourimmunology, Robert Rossle Clinic, Charite, Humboldt University of Berlin, Berlin, Germany
    Leukemia 17:900-9. 2003
  5. pmc ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
    N Isakov
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 181:375-80. 1995
  6. ncbi Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
    D I Godfrey
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 152:4783-92. 1994
  7. ncbi Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells
    Karin Fischer
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Blood 105:2828-35. 2005
  8. ncbi Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
    Bart Keymeulen
    Academic Hospital and Diabetes Research Center, Brussels Free University VUB, Brussels
    N Engl J Med 352:2598-608. 2005
  9. pmc Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    Sylvaine You
    Universite Paris Descartes, 75015 Paris, France
    Proc Natl Acad Sci U S A 104:6335-40. 2007
  10. ncbi CD3-specific antibodies: a portal to the treatment of autoimmunity
    Lucienne Chatenoud
    Universite Rene Descartes, Paris 5, Institut National de la Sante et de la Recherche Medicale, Unité 580, Hopital Necker Enfants Malades, 161 rue de Sèvres 75743 Paris CEDEX 15, France
    Nat Rev Immunol 7:622-32. 2007

Research Grants

Detail Information

Publications262 found, 100 shown here

  1. pmc Targeted adenovirus-mediated gene delivery to T cells via CD3
    T J Wickham
    GenVec, Inc, Rockville, Maryland 20852 1709, USA
    J Virol 71:7663-9. 1997
    ..These results demonstrate that bsAbs can target Ad to non-Ad receptors on cells that are normally resistant to Ad, resulting in their efficient and specific transduction...
  2. ncbi Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes
    David A Zapata
    Inmunologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 279:24485-92. 2004
    ..CD3 from CD4(+) and CD8(+) wild type T cells. The differences may be relevant for cis interactions during antigen recognition and signal transduction...
  3. ncbi Innate immune functions of human gammadelta T cells
    Susann Beetz
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstrasse 5, D 24105 Kiel, Germany
    Immunobiology 213:173-82. 2008
    ..We discuss these findings in the context of the suspected role of human Vgamma9Vdelta2 T cells as a link between innate and adaptive immune responses...
  4. ncbi Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
    A Löffler
    Department of Haematology, Oncology and Tumourimmunology, Robert Rossle Clinic, Charite, Humboldt University of Berlin, Berlin, Germany
    Leukemia 17:900-9. 2003
    ..Although anti-CD95 antibody CH-11 failed to induce apoptosis in lymphoma cells, we provide evidence that B-CLL cell depletion by bscCD3 x CD3 is mediated at least in part by apoptosis via the caspase pathway...
  5. pmc ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
    N Isakov
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 181:375-80. 1995
    ..The cooperativity ensures higher affinity for the doubly phosphorylated ligand. Affinity differences of as much as 30-fold indicates a significant specificity of interaction of ZAP-70 SH2 domains for different phospho-TAMs...
  6. ncbi Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
    D I Godfrey
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 152:4783-92. 1994
    ....
  7. ncbi Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells
    Karin Fischer
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Blood 105:2828-35. 2005
    ..DN Treg cells may serve to limit clonal expansion of allo-Ag-specific T cells after transplantation...
  8. ncbi Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
    Bart Keymeulen
    Academic Hospital and Diabetes Research Center, Brussels Free University VUB, Brussels
    N Engl J Med 352:2598-608. 2005
    ..To provide proof of this therapeutic principle at the metabolic level, we initiated a phase 2 placebo-controlled trial with a humanized antibody, an aglycosylated human IgG1 antibody directed against CD3 (ChAglyCD3)...
  9. pmc Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    Sylvaine You
    Universite Paris Descartes, 75015 Paris, France
    Proc Natl Acad Sci U S A 104:6335-40. 2007
    ....
  10. ncbi CD3-specific antibodies: a portal to the treatment of autoimmunity
    Lucienne Chatenoud
    Universite Rene Descartes, Paris 5, Institut National de la Sante et de la Recherche Medicale, Unité 580, Hopital Necker Enfants Malades, 161 rue de Sèvres 75743 Paris CEDEX 15, France
    Nat Rev Immunol 7:622-32. 2007
    ..This Review summarizes the pre-clinical and clinical studies of CD3-specific monoclonal antibody therapy and highlights future opportunities to enhance the efficacy of this potent immunotherapeutic...
  11. pmc Micropatterning of costimulatory ligands enhances CD4+ T cell function
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7791-6. 2008
    ..With these patterns, we show that the peripheral presentation of CD28 has a larger impact on IL-2 secretion than CD3 colocalization/segregation...
  12. ncbi Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
    ..Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair...
  13. ncbi AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation
    Xiaoyan Zhong
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Biol Chem 279:45676-84. 2004
    ..These data suggest that gp78-p97/VCP interaction may represent one way of coupling ubiquitination with retrotranslocation and degradation of ERAD substrates...
  14. ncbi Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
    G Pages
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Science 286:1374-7. 1999
    ..The p44 MAPK apparently has a specific role in thymocyte development...
  15. pmc Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
    T Brdicka
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic
    J Exp Med 191:1591-604. 2000
    ..These findings collectively suggest that in the absence of external stimuli, the PAG-Csk complex transmits negative regulatory signals and thus may help to keep resting T cells in a quiescent state...
  16. ncbi IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches
    H Yoshida
    Department of Molecular Genetics, Faculty of Medicine, Institute of Genetics, Faculty of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyoku, Kyoto 606 850, Japan
    Int Immunol 11:643-55. 1999
    ..Intestinal IL-7Ralpha+ cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2-/- mice. These results implicate IL-7Ralpha+ CD3(-) cells as the direct inducer of the organizing center of PP...
  17. ncbi CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
    Omid Akbari
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 354:1117-29. 2006
    ..Because mouse models of allergic asthma indicate that natural killer T cells are required for the development of allergen-induced airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human asthma...
  18. ncbi Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
    M O Westendorp
    Tumorimmunology Program, German Cancer Research Centre, Heidelberg
    Nature 375:497-500. 1995
    ..Taken together, our results indicate that HIV-1 Tat and gp120 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+ T-cell depletion in AIDS...
  19. pmc Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-cell activation
    Min Wang
    Interdepartmental Biological Sciences Program, Northwestern University, Evanston, IL, USA
    BMC Genomics 9:225. 2008
    ..Significantly, a comparative genome-scale transcriptional analysis of two T-cell subsets (CD4+ and CD8+) against each other and against the naturally mixed population (CD3+ cells) remains unexplored...
  20. pmc Deficiency of small GTPase Rac2 affects T cell activation
    H Yu
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 194:915-26. 2001
    ..The phenotypic similarity of Rac2(-/-) to Vav(-/-) cells implicates Rac2 as a downstream mediator of Vav signaling...
  21. ncbi Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    R E Mebius
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Immunity 7:493-504. 1997
    ..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
  22. ncbi Pregnancy-associated exosomes and their modulation of T cell signaling
    Douglas D Taylor
    Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 176:1534-42. 2006
    ....
  23. ncbi The implications of subunit interactions for the structure of the T cell receptor-CD3 complex
    F Koning
    Department of Immunohematology, University Hospital, Leiden, The Netherlands
    Eur J Immunol 20:299-305. 1990
    ..The data further indicate that gamma epsilon and delta epsilon complexes interact directly with the TcR chains. Based on the observations a model for the structure of the TcR-CD3 is presented and discussed...
  24. ncbi Initiation of TCR signaling: regulation within CD3 dimers
    Balbino Alarcon
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Madrid, Spain
    Immunol Rev 191:38-46. 2003
    ..How the presence of TCR in clusters influences TCR avidity and propagation of TCR signals is something that has yet to be investigated...
  25. ncbi Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells
    Charles A Stewart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, and Service d Immunologie, Hopital de Conception, Assistance Publique Hopitaux de Marseille, France
    Eur J Immunol 37:1442-52. 2007
    ..Instead, it ascribes chronic TCRgammadelta engagement as a means of acquiring NK-like function...
  26. ncbi Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling
    Michael S Kuhns
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 26:357-69. 2007
    ..These data demonstrate that extracellular TCR-CD3 subunit interactions contribute to the structural integrity and function of this multisubunit receptor...
  27. ncbi Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse
    Tomasz Zal
    Deptartment of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 16:521-34. 2002
    ..This interaction is blocked by the presence of antagonist ligands without decreasing the recruitment of zeta and CD4 or preventing their partial colocalization in the immunological synapse...
  28. ncbi Inhibition of graft-versus-host disease by double-negative regulatory T cells
    Kevin J Young
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Canada
    J Immunol 171:134-41. 2003
    ..This finding indicates that using single class I locus-mismatched grafts may be a viable alternative to using fully matched grafts in bone marrow transplantation...
  29. ncbi The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    Dominik Wolf
    Division of Hematology and Oncology, Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Clin Cancer Res 11:8326-31. 2005
    ..The aim of the presented study was determine the prognostic effect of FoxP3 mRNA expression (reflecting the tissue content of Treg) in ovarian carcinoma and its relation with cytokines, such as IFN-gamma...
  30. ncbi A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
    F Letourneur
    Cell Biology and Metabolism Branch, National Institute of Child Health, Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Cell 69:1143-57. 1992
    ..These two sequences may represent two families of targeting motifs that determine the fate of proteins within the peripheral membrane system...
  31. pmc Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
    Rui Chen
    Department of Medicine, Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA
    J Cell Biol 166:193-203. 2004
    ..We suggest that this functional interaction of Bcl-2 with InsP3Rs inhibits InsP3R activation and thereby regulates InsP3-induced calcium release from the ER...
  32. ncbi T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    Douglas D Taylor
    Departments of Obstetrics and Gynecology and Radiation Oncology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Clin Cancer Res 9:5113-9. 2003
    ....
  33. ncbi The T-cell receptor signalosome: a dynamic structure with expanding complexity
    Guy Werlen
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, CH 4031, Basel, Switzerland
    Curr Opin Immunol 14:299-305. 2002
    ..This review describes how 'vertical' displacement mechanisms and lateral coalescence of lipid-raft-associated scaffold proteins combine to form distinct signalosomes, which control signal specificity...
  34. pmc Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif
    Chenqi Xu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 135:702-13. 2008
    ..Sequestration of key tyrosines into the lipid bilayer represents a previously unrecognized mechanism for control of receptor activation...
  35. pmc Bcl-XL and Bcl-2 repress a common pathway of cell death
    D T Chao
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 182:821-8. 1995
    ..Immunoprecipitation indicated that Bcl-xL, like Bcl-2, heterodimerized with the death-promoting molecule Bax in thymocytes. This in vivo model argues that Bcl-xL, like Bcl-2, functions in a common pathway to repress cell death...
  36. pmc Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques
    Michael Schindler
    Department of Virology, Universitatsklinikum, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Virol 78:10588-97. 2004
    ....
  37. ncbi CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study
    Luigi Laghi
    Laboratories of Molecular Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Lancet Oncol 10:877-84. 2009
    ..The aim of this study was to assess the relationship between the density of CD3+ TIL and the postsurgical occurrence of distant-organ metastases in a large series of patients with deeply invading and MSI-typed colorectal cancer...
  38. ncbi The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules
    A M Wegener
    Centre d Immunologie, INSERM CNRS de Marseille Luminy, France
    Cell 68:83-95. 1992
    ....
  39. ncbi The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains
    N Manolios
    Rheumatology Department, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia
    Eur J Immunol 24:84-92. 1994
    ..Similarly, there was no interaction between TCR-beta and zeta. These findings when coupled with the information on pairwise interactions and formation of higher order subcomplexes extend our model for the structure of the TCR complex...
  40. ncbi Differential biological role of CD3 chains revealed by human immunodeficiencies
    María J Recio
    Inmunologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Immunol 178:2556-64. 2007
    ..We propose a CD3delta >> CD3gamma hierarchy for the relative impact of their absence on the signaling for T cell production in humans...
  41. ncbi Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency
    Harjit K Dadi
    Divisions of Immunology and Allergy and the Infection, Immunity, Injury and Repair Program, The Research Institute and The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    N Engl J Med 349:1821-8. 2003
  42. ncbi Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    Lydie Trautmann
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, 264 Rene Levesque Est, Montreal, Québec H2X1P1, Canada
    Nat Med 12:1198-202. 2006
    ..The accumulation of HIV-specific dysfunctional CD8(+) T cells in the infected host could prevent the renewal of a functionally competent HIV-specific CD8(+) repertoire...
  43. ncbi Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation
    E N Kersh
    Center for Immunology and Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 281:572-5. 1998
    ..Thus, the phosphorylation steps establish thresholds for T cell activation. This study documents the sophisticated molecular events that follow the engagement of a low-affinity receptor...
  44. ncbi Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells
    Guojiang Chen
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road, No 27, Beijing, 100850, China
    J Leukoc Biol 83:280-7. 2008
    ..These findings may have an important implication for understanding the involved mechanisms responsible for immunomodulatory function of anti-CD3 antibody on autoimmune diseases...
  45. ncbi CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation
    S G Tangye
    Immunobiology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 161:3249-55. 1998
    ..CD148-induced proliferation was significantly greater for CD8+ T cells than for CD4+ T cells. Thus, CD148 is a receptor-type protein tyrosine phosphatase involved in the activation of T lymphocytes...
  46. ncbi Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50
    Bassam M Badran
    Laboratory of Experimental Hematology, Faculty of Medicine, University of Brussels, 121 Blvd de Waterloo, Brussels B1000, Belgium
    J Biol Chem 277:47136-48. 2002
    ..Finally, we have shown that an increase in the binding of nuclear NFATc2, NFATc1, and NF-kappaB p50 to these three motifs is correlated with a progressive loss of CD3gamma transcripts after HIV-1 infection...
  47. ncbi Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma
    Lorna J Wood
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:883-9. 2002
    ....
  48. ncbi A new trigger for T cells
    Mark M Davis
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 110:285-7. 2002
    ..A recent study has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck...
  49. ncbi Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class
    Klaus Brischwein
    Micromet AG, Munich, Germany
    J Immunother 30:798-807. 2007
    ..BiTE molecules therefore qualify for a highly controlled polyclonal T-cell therapy of cancer...
  50. ncbi IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes
    Els Verhoeyen
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Ecole Normale Superieure de Lyon, Lyon, France
    Blood 101:2167-74. 2003
    ..With adult naive T cells, preactivation with recombinant IL-7 was necessary for efficient gene transfer. Altogether, these results suggest that IL-7-displaying vectors could constitute interesting tools for T-cell-targeted gene therapy...
  51. pmc The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes
    B Alarcon
    Laboratory of Molecular Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    EMBO J 10:903-12. 1991
    ..The existence of these two forms of TCR/CD3 complexes could have important implications in the understanding of T cell receptor function and its role in T cell development...
  52. pmc Altered effector function of peripheral cytotoxic cells in COPD
    Richard A Urbanowicz
    COPD Research Group, Institute of Infection, Immunity and Inflammation, The University of Nottingham, UK
    Respir Res 10:53. 2009
    ..We investigated the characteristics of the three main perforin and granzyme containing peripheral cells, namely CD8+ T lymphocytes, natural killer (NK; CD56+CD3-) cells and NKT-like (CD56+CD3+) cells...
  53. ncbi Role of double-negative regulatory T cells in long-term cardiac xenograft survival
    Wenhao Chen
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2C4 Canada
    J Immunol 170:1846-53. 2003
    ....
  54. pmc Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion
    Y Shimizu
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109
    J Exp Med 175:577-82. 1992
    ..Enhanced expression/function of adhesion-inducing molecules thus overcomes relative deficits in adhesion receptor expression...
  55. ncbi Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency
    C Soudais
    INSERM U 132, Hopital Necker Enfants Malades, Paris, France
    Nat Genet 3:77-81. 1993
    ....
  56. ncbi Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis
    Adam P Kohm
    Department of Microbiology Immunology and Interdepartmental Immunobiology Center, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 174:4525-34. 2005
    ....
  57. ncbi Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104
    Clara Brando
    The Wistar Institute, Philadelphia, PA, USA
    J Leukoc Biol 78:359-71. 2005
    ..The data demonstrate the ability of TALL-104 cells to recognize a wide variety of tumors with NK cell receptors and kill them with a broad arsenal of cytolytic effector mechanisms, including cytolytic granules and TNF family ligands...
  58. ncbi Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies
    N A Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, AZ 85259, USA
    J Immunol 158:1332-44. 1997
    ..These pathologies parallel clinical observations of patients with a profound eosinophilia and imply that IL-5 effector functions during some inflammatory responses may be contingent upon peripheral lymphohemopoietic expression...
  59. pmc CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage
    V P Dave
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    EMBO J 16:1360-70. 1997
    ..Absence of CD3 delta specifically blocks the thymic selection processes that mediate the transition from the double-positive to single-positive stages of development...
  60. ncbi Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease
    Paloma Valverde
    Department of Oral and Developmental Biology, Harvard Medical School and Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Bone Miner Res 19:155-64. 2004
    ..This study suggests a plausible therapeutic approach for inflammatory bone resorption by targeting Kv1.3...
  61. ncbi Immunophenotyping of blood lymphocytes at birth, during childhood, and during adulthood in HIV-1-uninfected Ethiopians
    Aster Tsegaye
    Ethio Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia
    Clin Immunol 109:338-46. 2003
    ..The immune alterations including the remarkably low CD4 count with highly depleted naîve phenotype and a persistently activated immune system seen in adult Ethiopians are not apparent at birth, but rather develop over time...
  62. ncbi Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene
    W R Drobyski
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Blood 97:2506-13. 2001
    ..These studies demonstrate that administration of TK gene-modified donor T cells can be used as an approach to mitigate GVHD without compromising alloengraftment...
  63. ncbi T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct
    Torsten Dreier
    Micromet AG, Munich, Germany
    J Immunol 170:4397-402. 2003
    ..These properties make bscCD19xCD3 superior to previously investigated CD19 bispecific Ab-based therapies...
  64. ncbi TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    Meriam Belghith
    INSERM U580, IRNEM, Hopital Necker, 161 rue de Sevres, 75015 Paris, France
    Nat Med 9:1202-8. 2003
    ..These data explain the intriguing tolerogenic effect of CD3-specific antibodies and position them as the first clinically applicable pharmacological stimulant of TGF-beta-producing regulatory CD4+ T cells...
  65. ncbi Functional evaluation of proliferative T cell responses in patients with severe T lymphopenia: characterization of optimal culture conditions and standardized activation signals for a simple whole blood assay
    Øystein Wendelbo
    Division for Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway
    J Hematother Stem Cell Res 12:525-35. 2003
    ..Detectable proliferation is observed for most patients with treatment-induced cytopenia. We conclude that the assay can be used for functional characterization of remaining T lymphocytes in patients with severe T lymphopenia...
  66. ncbi The Src family kinase Fyn mediates signals induced by TCR antagonists
    Qizhi Tang
    The Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 168:4480-7. 2002
    ..Overexpression of Fyn, but not Lck, restored the mitogenicity of FcR nonbinding anti-CD3 in primary T cells. Taken together, these results suggest that Fyn mediates the partial signaling induced by TCR antagonists...
  67. ncbi Regulation of constitutive TCR internalization by the zeta-chain
    Ugo D'Oro
    Chiron, Siena, Italy
    J Immunol 169:6269-78. 2002
    ....
  68. ncbi Selective lymphocyte chemokine receptor expression in the rheumatoid joint
    J H Ruth
    Northwestern University Medical School, Department of Medicine, Section of Rheumatology, Chicago, IL 60611, USA
    Arthritis Rheum 44:2750-60. 2001
    ..CONCLUSION: These results identify CCR4, CCR5, CXCR3, and CX3CR1 as critical chemokine receptors in RA...
  69. ncbi The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct
    Christian Brandl
    Micromet AG, Staffelseestr 2, 814777, Munich, Germany
    Cancer Immunol Immunother 56:1551-63. 2007
    ..Glucocorticoids thus qualify as a potential co-medication for therapeutic BiTE molecules and other cytotoxic T cell therapies for treatment of cancer...
  70. pmc Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine
    C P Liu
    Division of Immunology, Beth Israel Hospital Harvard Medical School, Boston, MA 02215
    EMBO J 12:4863-75. 1993
    ..In comparison to thymus-derived peripheral T cells in the spleen and lymph nodes, the preferential expression of normal levels of TCR/CD3 in intestinal IELs suggested they mature via an independent extrathymic pathway...
  71. ncbi On the role of CD3delta chains in TCRgammadelta/CD3 complexes during assembly and membrane expression
    L Alibaud
    , CNRS-UPR 2163, Institut Claude de Preval, IFR 30, CHU de Purpan, 31059 Toulouse, Cedex 03, France
    Scand J Immunol 54:155-62. 2001
    ..These data may explain, at the molecular levels, why surface TCR/CD3 expression levels are impaired in gammadelta-T cells from CD3gamma-deficient mice but not from CD3delta-deficient mice...
  72. ncbi Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
    Diana Gil
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid 20849, Spain
    Cell 109:901-12. 2002
    ..Finally, by interfering with Nck-CD3 epsilon association in vivo, we demonstrate that TCR-CD3 recruitment of Nck is critical for maturation of the immune synapse and for T cell activation...
  73. ncbi TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes
    K P Kearse
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 2:391-9. 1995
    ....
  74. ncbi Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
    H Nishina
    The Amgen Institute, Ontario Cancer Institute, Toronto, Canada
    Nature 385:350-3. 1997
    ..These data indicate that SEK1 mediates survival signals in T-cell development...
  75. ncbi Analysis and expression of a cloned pre-T cell receptor gene
    C Saint-Ruf
    Unité INSERM 373, Institut Necker, Paris, France
    Science 266:1208-12. 1994
    ..Identification of the pT alpha gene represents an essential step in the structure-function analysis of the pre-TCR complex...
  76. ncbi Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha
    H J Fehling
    Basel Institute for Immunology, Switzerland
    Immunity 6:703-14. 1997
    ..These results allow a better definition of the role of pT alpha in pre-TCR signal transduction and provide conclusive evidence that the cytoplasmic tail of pT alpha is not essential for pre-TCR signaling...
  77. ncbi T cell development in mice that lack the zeta chain of the T cell antigen receptor complex
    P E Love
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD 20892
    Science 261:918-21. 1993
    ..Thus, zeta chain expression influences thymocyte differentiation but is not absolutely required for the generation of single positive T cells...
  78. ncbi Expression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes
    N Wang
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int Immunol 10:1777-88. 1998
    ..These results demonstrate that CD3 epsilon does not regulate expression of CD3 gamma and delta genes, and underscore the capacity of each prothymocyte to give rise to a large number of mature peripheral T cells...
  79. pmc The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages
    M C Haks
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 17:1871-82. 1998
    ..The defect in the DN to double positive transition in mice lacking CD3gamma can be overcome by anti-CD3epsilon-mediated cross-linking. CD3gamma is thus essential for pre-TCR function...
  80. ncbi bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
    C L Sentman
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 67:879-88. 1991
    ..This transgenic model indicates that multiple death pathways operate within the thymus that can be distinguished by their dependence on bcl-2...
  81. pmc Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones
    D L Wiest
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:1884-9. 1997
    ..Thus, the cellular process of ER retention is incomplete in immature thymocytes and provides an explanation for surface expression of partial receptor complexes that transduce differentiative signals during thymic development...
  82. ncbi Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion
    M Senoo
    Department of Molecular Oncology, Nippon Roche Research Center, Kamakura City, Kanagawa, Japan
    Int Immunol 10:553-60. 1998
    ..These data indicate that the regulation of Vbeta germline transcription by the signals through the pre-TCR complex may reflect the modulation of Vbeta accessibility to the VDJ recombinase, which contributes to TCR beta allelic exclusion...
  83. ncbi Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT
    S C Bunnell
    Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 14:315-29. 2001
    ..In addition, the maintenance of the resulting contact requires sustained calcium influxes, an intact microtubule cytoskeleton, and functional LAT...
  84. pmc Vav regulates peptide-specific apoptosis in thymocytes
    Y Y Kong
    Amgen Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    J Exp Med 188:2099-111. 1998
    ..Our results indicate that peptide-triggered thymocyte apoptosis is mediated via Vav activation, changes in the actin cytoskeleton, and subsequent activation of a PKC isoform...
  85. pmc Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
    M A Murphy
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne 3000, Parkville 3050, Victoria, Australia
    Mol Cell Biol 18:4872-82. 1998
    ..Our findings demonstrate critical roles for c-Cbl in hemopoiesis and in controlling cellular proliferation and signalling by the Syk/ZAP-70 family of protein kinases...
  86. ncbi Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose
    A H Guse
    Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany
    Nature 398:70-3. 1999
    ..Thus we show the presence, causal relation and biological significance of the major constituents of the cADPR/calcium-signalling pathway in human T cells...
  87. ncbi Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells
    Hirofumi Ochi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:627-35. 2006
    ..These findings identify a new immunologic approach that is widely applicable for the treatment of human autoimmune conditions...
  88. ncbi CD3 delta establishes a functional link between the T cell receptor and CD8
    Marie Agnès Doucey
    Institute for Biochemistry, University of Lausanne, Epalinges 1066, Switzerland
    J Biol Chem 278:3257-64. 2003
    ..Thus, CD3 delta couples TCR.CD3 with raft-associated CD8, which is required for effective activation and positive selection of CD8(+) T cells...
  89. ncbi GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
    Simona Ronchetti
    Eur J Immunol 34:613-22. 2004
    ..These results indicate a novel function for GITR as costimulatory molecule of T cell subsets...
  90. ncbi Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Curr Opin Immunol 19:365-72. 2007
    ..In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area...
  91. pmc Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    Damien Bresson
    Department of Developmental Immunology 3, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 116:1371-81. 2006
    ..Since Tregs act site-specifically, this strategy should also be expected to reduce the potential for systemic side effects...
  92. ncbi Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer
    Z J Sun
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 105:913-23. 2001
    ..These biochemical and structural analyses offer insights into the modular pairwise association of CD3 invariant chains. More importantly, the findings suggest how the rigidified CD3 elements participate in TCR-based signal transduction...
  93. ncbi High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas
    S le Gouvello
    Department of Gastroenterology, Hopital Henri Mondor, 51 Av du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Gut 57:772-9. 2008
    ..The aim of the present study was to characterise the intratumoural expression of markers associated with the antitumour immune response in mismatch repair (MMR)-proficient (MSS) colon cancers...
  94. ncbi CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load
    Ana E Sousa
    Clinical Immunology Unit Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Lisbon, Portugal
    J Immunol 169:3400-6. 2002
    ....
  95. ncbi Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin
    Hui Yang
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 W Lombard Street, Baltimore, MD 21201, USA
    Exp Cell Res 313:538-50. 2007
    ..These results suggest that Hrd1 is a novel htt-interacting protein that can target pathogenic httN for degradation and is able to protect cells against httN-induced cell death...
  96. ncbi Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy
    Nattawat Onlamoon
    Department of Pathology and Lab Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Med Primatol 35:178-93. 2006
    ..Our laboratory has previously shown that adoptive transfer of in vitro-expanded autologous purified polyclonal CD4(+) T cells using anti-CD3/CD28-coated beads induced antiviral responses capable of controlling SIV replication in vivo...
  97. pmc The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune sy
    K Takeda
    Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033
    J Exp Med 177:155-64. 1993
    ....
  98. ncbi Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy
    Shujuan Liu
    Surgery Branch, National Cancer Institute NCI, Bethesda, Maryland 20892 1502, USA
    J Immunother 29:284-93. 2006
    ....
  99. ncbi Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation
    Andreas Sturm
    Medizinische Klinik mit Sektion Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Immunol 173:3825-37. 2004
    ....
  100. ncbi A unique population of extrathymically derived alpha beta TCR+CD4-CD8- T cells with regulatory functions dominates the mouse female genital tract
    Martina Johansson
    Department of Clinical Immunology, University of Goteborg, S 413 46 Goteborg, Sweden
    J Immunol 170:1659-66. 2003
    ..A large fraction of the cells expressed CD25 and produced IFN-gamma upon anti-CD3 plus anti-CD28 stimulation, arguing for a strong regulatory role of this novel T cell population in the mouse female genital tract...
  101. ncbi The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function
    Andrea L Szymczak
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 175:270-5. 2005
    ..These data suggest that the interaction between the CD3epsilon PRS and Nck, or any other Src homology 3 domain-containing molecule, is not essential for T cell development and function...

Research Grants76

  1. Aberrant Crypt Foci as a Biomarker for Chemoprevention
    Frank Sinicrope; Fiscal Year: 2009
    ....
  2. MOLECULAR MECHANISMS OF T LYMPHOCYTE ACTIVATION
    Stanford Stewart; Fiscal Year: 1991
    ..These studies should significantly improve our understanding of the phenomenon of T lymphocyte activation and have broad implications for control of immunological events and cellular proliferation including neoplasia...
  3. SUBCELLULAR BASIS FOR HUMAN T CELL SENESCENCE
    RISE SCHWAB; Fiscal Year: 1992
    ..3. To determine whether a failure to transduce cell surface signals results in an alteration in the defined pathway of transcription associated with T cell proliferation...
  4. ANALYSIS OF A NEW HUMAN T CELL-ACTIVATION ANTIGEN (2H1)
    CHRISTOPHER RUDD; Fiscal Year: 1992
    ....
  5. Tumor-reactive IgG in the diagnosis of ovarian cancer
    Douglas Taylor; Fiscal Year: 2005
    ..Ultimately, antigenic proteins, linked with histologic type and stage of disease, will be combined into the development of protein arrays to screen for circulating reactive IgG as an early diagnostic test. ..
  6. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
  7. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2008
    ..abstract_text> ..
  8. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  9. T CELL ACTIVATION FOR CANCER IMMUNOTHERAPY
    Alfred Chang; Fiscal Year: 2008
    ..We have extensive experience in the conduct of adoptive immunotherapy and vaccine trials in humans that will allow translation of these findings. ..
  10. RESEARCH TRAINING IN TRANSLATIONAL TUMOR IMMUNOLOGY
    Alfred Chang; Fiscal Year: 2005
    ..Predoctoral and postdoctoral trainees should leave the program well prepared for academic careers focused on translational aspects of immunologic research as it pertains to the development of new strategies for the treatment of cancer. ..
  11. Cognitive Behavioral Stress Management for Chronic Fatigue Syndrome
    Michael Antoni; Fiscal Year: 2009
    ....
  12. FACILITATING POSITIVE ADAPTATION TO BREAST CANCER
    MICHAEL HOWARD ANTONI; Fiscal Year: 2010
    ..abstract_text> ..
  13. T CELL THERAPY OF HUMAN RENAL CELL CANCER
    Alfred Chang; Fiscal Year: 2007
    ..Lloyd Stoolman. Dr. Stoolman plans to examine novel methods to enrich tumor reactive lymphoid cells based upon adhesion marker expansion utilizing samples generated from this proposal. ..
  14. Experimental Uveal Melanoma and Ocular Immune Privilege
    KYLE MCKENNA; Fiscal Year: 2007
    ..abstract_text> ..
  15. CONTROL SELECTION METHODS FOR CHILDHOOD CANCER STUDIES
    Greta Bunin; Fiscal Year: 2009
    ..A feasible and valid control group is needed to ensure that studies of childhood cancer are scientifically valid and therefore, will provide results that can eventually lead to prevention of these cancers. ..
  16. Polypeptide Hormone Receptor Recognition and Activation
    KENAN GARCIA; Fiscal Year: 2007
    ..abstract_text> ..
  17. Mechanisms of Radiation Induced Fatigue in Cancer
    Julienne Bower; Fiscal Year: 2006
    ..Together with a targeted program of didactic instruction, this project will prepare the candidate to become a fully independent behavioral scientist in the field of cancer prevention and control research. ..
  18. THE ROLE OF CHEMOKINES IN AUTOIMMUNE ENCEPHALOMYELITIS
    William Karpus; Fiscal Year: 2009
    ..These studies will help to understand the immunopathogenesis of MS and provide a basis for the development of novel chemokine and chemokine receptor therapies for treatment of ongoing disease. ..
  19. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  20. Gene expression in memory CD4+T cells.
    Henry Wong; Fiscal Year: 2006
    ..abstract_text> ..
  21. THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTION
    Martin Schwacha; Fiscal Year: 2006
    ..This award along with the excellent environment in the Center for Surgical Research for conducting these studies will significantly facilitate the applicant's further development as an Independent Investigator. ..
  22. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  23. Validation of a Novel NF-KB Inhibitor in Murine IBD
    Scott Plevy; Fiscal Year: 2006
    ..If these studies are successful, future studies will be designed to assess the safety of this new compound, and rapidly develop this treatment to evaluate in people with IBD. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Targeting protein synthesis in AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies will hopefully lead to the design of pivotal phase II and III clinical trials which will define the role of DT388IL3 in the management of AML. ..
  25. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..The follow-up trial will be a phase II study to determine the efficacy of 131I-HuCC49ACH2 in resistant/refractory EOC patients. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Phase resetting using DC stimulation for seizure blockage
    Ivan Osorio; Fiscal Year: 2007
    ..3B. The significant advances made in the control of fatal arrhythmias are in part attributable to the use by cardiologists of phase resetting as an investigative and therapeutic tool. [unreadable] [unreadable] [unreadable]..
  27. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  28. Role of Vav family proteins in cell signaling and cancer
    XOSE BUSTELO; Fiscal Year: 2009
    ..abstract_text> ..
  29. MOP/LAS chimeric vaccine against Lassa fever
    Igor Lukashevich; Fiscal Year: 2007
    ..Our long-range goal is to understand LAS virus pathogenesis and to develop effective treatments and vaccines. ..
  30. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  31. Cbl Mediated Ubiquitination in Autoimmunity
    Hua Gu; Fiscal Year: 2010
    ..Completion of this work will bring insight into cellular and molecular mechanisms by which Cbl proteins control B-cell tolerance and autoimmune diseases. It might also provide tool for clinic therapy. ..
  32. Occupational Pesticide Exposure of Parents and Brain Tumor Risk in Children
    Greta Bunin; Fiscal Year: 2008
    ..The proposed study will provide information on the usefulness of these approaches. [unreadable] [unreadable] [unreadable]..
  33. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. Aging and thymopoiesis: Changes in stroma, T-presursors
    Phong Le; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. Tumor Induced Dysregulation of T Cell Immunity
    James H Finke; Fiscal Year: 2010
    ..We will also define the sequence of events leading to T cell death, including the role of iron and lysosomes in this process (aim 3) ..
  36. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  37. Genetic Basis for susceptibility to Experimental Autoimmune Encephalomyelitis
    Vijay Kuchroo; Fiscal Year: 2008
    ..abstract_text> ..
  38. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  39. GLOBIN GENE TRANSFER FOR THERAPY OF SICKLE CELL ANEMIA
    Michel Sadelain; Fiscal Year: 2004
    ....
  40. LASER CAPTURE MICROSCOPE
    Carol Petito; Fiscal Year: 2001
    ..Consequently, we request a camera and a workstation for the double headed microscope. This will be exclusively be utilized by Users of the LCM facility. ..
  41. OXIDANT STRESS AND ENDOTHELIAL CELL METABOLISM
    LORRAINE SORDILLO; Fiscal Year: 2001
    ..Results form these studies will provide the molecular basis of how Se deficiency can modify resistance to metabolic vascular disorders. ..
  42. Healing Touch, Immunity, and Fatigue in Breast Cancer
    Susan Lutgendorf; Fiscal Year: 2004
    ....
  43. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
    ..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
  44. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2004
    ..These findings may provide the basis for the rational design of future immunotherapy trials for the treatment of melanoma or other malignancies. ..
  45. EXTRAVASCULAR TRAFFICKING OF HIV+ CELLS AND PROGNOSIS
    Holly Birdsall; Fiscal Year: 2003
    ....
  46. STRESS RESPONSES AND APOPTOSIS
    Clark Distelhorst; Fiscal Year: 2003
    ....
  47. MYCOPLASMA INFECTIONS AND CHILDHOOD ASTHMA
    T Atkinson; Fiscal Year: 2002
    ..Finally, I plan to investigate the effects of infection in a mouse model of asthma, which will permit the use of deletional mutant strains in the investigation of pathogenic mechanisms. ..
  48. Epitope specificity of vaccine-induced anti-HIV IgG /IgA
    HERMAN STAATS; Fiscal Year: 2002
    ....
  49. SNO GENE FUNCTION IN GROWTH AND DEVELOPMENT
    Sonia Pearson White; Fiscal Year: 2002
    ..These studies will establish the contribution of the Ski/Sno gene family to the genetic regulation of development in the embryo. Health-related benefits include possible insights into hemolymphopoietic cell function and birth defects. ..
  50. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..3. To characterize the T-cell dysfunction of patients with active pulmonary tuberculosis, its relationship to TGF-beta and other suppressive cytokines (IL-10) and its reversal by inhibitors of TGF- beta. ..
  51. NEUROIMMUNOLOGY OF AED IN OCULAR HSV-1 INFECTION
    Daniel Carr; Fiscal Year: 2001
    ..abstract_text> ..
  52. REGULATION OF NATURAL KILLER CELLS
    Raymond Welsh; Fiscal Year: 2005
    ..This work should clarify how these effector systems act and interact to rid the host of infectious agents and tumors. ..
  53. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
  54. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
  55. How Does blockade of CD40/CD40L Prevent Autoimmunity?
    Matthias von Herrath; Fiscal Year: 2005
    ..Therefore, the direct comparison of three autoimmune models will enable us to define, which in vivo consequences of costimulation blockade occur more commonly and which are restricted to a given experimental situation. ..
  56. Anti-Viral Gene Delivery in the Nervous System
    Daniel Carr; Fiscal Year: 2005
    ..abstract_text> ..
  57. EIAV Control by High Avidity Rev-Specific CTL Clones
    ROBERT MEALEY; Fiscal Year: 2005
    ..The information obtained from the proposed studies should have implications for HIV-1 immunotherapy and vaccine design, where experiments of this type may be more difficult. ..
  58. DNA Vaccination & Regulatory Cells in Type I Diabetes
    Matthias von Herrath; Fiscal Year: 2006
    ..abstract_text> ..
  59. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005
    ..In addition, they lay the groundwork for the analysis of B220+ DN T cell in healthy individuals and IBD patients. ..
  60. Advancing Islet Transplants for Type 1 Diabetes Care
    Bernhard Hering; Fiscal Year: 2008
    ..This study will also provide a rational basis for treatment recommendations for type 1 diabetic patients with early microvascular lesions. ..
  61. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
    ....
  62. SPECIFICITY AND DEGENERACY OF AUTOREACTIVE T CELL RECEPT
    Kai Wucherpfennig; Fiscal Year: 2002
    ..Analysis of the structural requirements for peptide binding and TCR recognition may have important implications for understanding the pathogenesis of MS and for designing peptide-based therapies. ..
  63. TCR Crossreactivity in Autoimmune Diseases
    Kai Wucherpfennig; Fiscal Year: 2009
    ..Definition of the structural and functional basis of TCR crossreactivity has important implications for understanding the pathogenesis of MS and other chronic inflammatory diseases. ..
  64. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
    ..abstract_text> ..
  65. ERM and Rho Signal Pathways in T Cell Immune Senescence
    GONZALO GARCIA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  66. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..The author hopes to reconstruct a system in which T cell clones induce production of desmoglein 3 autoantibodies. A number of cytokines will be explored in this system. ..
  67. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  68. Mechanisms of Antigen Presentation by MHC class II
    Kai Wucherpfennig; Fiscal Year: 2008
    ..T cell experiments will assess whether small molecule accelerators of DM prevent presentation of this self peptide to CD4 T cells. [unreadable] [unreadable]..
  69. T CELL UNRESPONSIVENESS IN HUMAN TUMORS
    James Finke; Fiscal Year: 2007
    ..This will involve defining the effect that sensitizing gangliosides have on mitochondrial stability. A better understanding of immune dysfunction may lead to ways in which to improve anti-tumor immunity. ..
  70. INHIBITION OF IL4 EXPRESSION IN CELLS RELEVANT TO ASTHMA
    Steve Georas; Fiscal Year: 2002
    ..Second, we will test the hypothesis that YY1 inhibits the IL-4 promoter in a sequence- specific manner. These studies should enhance our understanding of IL-4 gene expression. ..
  71. NFKB DEFECT AND APOPTOSIS IN T CELLS OF CANCER PATIENTS
    James Finke; Fiscal Year: 2003
    ..This assessment will also involve an analysis of select anti-apoptotic genes. These studies should assess whether the defect in NFkappaB and AICD sensitivity are linked and relate to patient outcome. ..
  72. Ganglioside Regulation of NFkbeta and Apoptosis
    James Finke; Fiscal Year: 2005
    ..These studies will provide insight into how gangliosides inhibit NFKB and survival gene expression, leading to increased T cell sensitivity to apoptosis. ..
  73. Combination fusion toxin and cytarabine therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2002
    ..We anticipate these studies should provide the basis for the design and implementation of pivotal multi-institutional phase II and III trials of DTGM/cytarabine therapy for relapsed/refractory AML. ..
  74. THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENT
    Stanford Peng; Fiscal Year: 2003
    ..abstract_text> ..
  75. Stem/Progenitor Cell Inversions With Cell Cycle Transit
    Gerald Colvin; Fiscal Year: 2007
    ..They promise to further define the basic nature of the hematopoietic marrow stem cells and could lead to interesting preclinical models for selective lineage support of various myeloablative therapy approaches . ..
  76. Diphtheria fusion protein therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies should lead to the design of pivotal phase II clinical trials to determine the role of this therapeutic in AML management. ..