Genomes and Genes
Summary: T-cell differentiation antigens that serve as the receptors for the B7 antigen (ANTIGENS, CD80) which modulates T-cell lymphokine production.
Publications261 found, 100 shown here
- The B7-CD28 superfamilyArlene H Sharpe
Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Rev Immunol 2:116-26. 2002..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
- CD28/B7 system of T cell costimulationD J Lenschow
Committee on Immunology, Ben May Institute, Chicago, Illinois 60637, USA
Annu Rev Immunol 14:233-58. 1996..It is our hope and expectation that this review will provoke additional research that will unravel this important, yet complex, signaling pathway...
- The interaction properties of costimulatory molecules revisitedAlison V Collins
Nuffield Department of Clinical Medicine, The University of Oxford, John Radcliffe Hospital, Headington, United Kingdom
Immunity 17:201-10. 2002..We propose that the distinct structures and binding properties of B7-1 and B7-2 account for their overlapping but distinct effects on T cell responses...
- CD28-mediated co-stimulation: a quantitative support for TCR signallingOreste Acuto
Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, Cedex 15, 75724 Paris, France
Nat Rev Immunol 3:939-51. 2003
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Heon Park
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1133-41. 2005..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
- Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantationB Salomon
The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
Annu Rev Immunol 19:225-52. 2001..The implications of these complexities and the potential for use of these therapies in clinical immune intervention are discussed...
- Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412Ganesh Suntharalingam
Department of Intensive Care Medicine, Northwick Park and St Mark s Hospital, Harrow, London, United Kingdom
N Engl J Med 355:1018-28. 2006..Documentation of the clinical course occurring over the 30 days after infusion offers insight into the systemic inflammatory response syndrome in the absence of contaminating pathogens, endotoxin, or underlying disease...
- CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1Donghai Wang
Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
Mol Cell Biol 24:164-71. 2004..Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation-induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse...
- Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cellsD J Fowell
Department of Medicine, University of California San Francisco 94143, USA
Immunity 11:399-409. 1999..Development of protective Th1 cells was unimpeded. These data define a nonredundant role for Itk in modulating signals from the TCR/CD28 pathways that are specific for the establishment of stable IL-4 but not IFNgamma expression...
- Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cellsJason M Brenchley
Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:2711-20. 2003..Thus, our studies define a phenotype associated with replicative senescence in HIV-specific CD8(+) T cells, which may have broad implications to other conditions associated with chronic antigenic stimulation...
- Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitisNiklas Beyersdorf
Institute for Virology and Immunobiology, University of Wurzburg, D 97078 Wurzburg, Germany
J Exp Med 202:445-55. 2005..Our data indicate that this class of CD28-specific monoclonal antibodies targets CD4+CD25+ T reg cells and provides a novel means for the effective treatment of multiple sclerosis and other autoimmune diseases...
- CD28nullCD4+ T cells--characterization of an effector memory T-cell population in patients with rheumatoid arthritisA E R Fasth
Rheumatology Unit, Department of Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Scand J Immunol 60:199-208. 2004....
- NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-thetaN Coudronniere
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 97:3394-9. 2000..These findings identify a unique PKCtheta-mediated pathway for the costimulatory action of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade...
- 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responsesJ T Tan
The Carlos and Marguerite Mason Transplantation Biology Research Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 163:4859-68. 1999....
- B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesB Salomon
Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
Immunity 12:431-40. 2000..The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases...
- The expansion of CD4+CD28- T cells in patients with rheumatoid arthritisAndrzej Pawlik
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian University of Medicine, Szczecin, Poland
Arthritis Res Ther 5:R210-3. 2003..The results suggest that the frequency of CD4+CD28- T cells may be a marker correlating with extra-articular manifestations and joint involvement...
- Identification and distribution of the costimulatory receptor CD28 in the mouseJ A Gross
Department of Molecular and Cell Biology, University of California, Berkeley 94720
J Immunol 149:380-8. 1992..The potent costimulatory function of CD28 on mature T cells, together with the high level of expression on CD4+8+ thymocytes, suggest that this costimulatory receptor might play an important role in T cell development and activation...
- Functional properties of CD4+ CD28- T cells in the aging immune systemC M Weyand
Mayo Clinic, Rochester, MN 55905, USA
Mech Ageing Dev 102:131-47. 1998..We propose that the emergence of CD28-deficient CD4 T cells in the elderly can partially explain age-specific aberrations in immune responsiveness...
- Memory CD8+ T cells require CD28 costimulationAnnie B Borowski
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Immunol 179:6494-503. 2007..These findings also raise questions about the efficacy of CD8(+) T cell-based vaccines against such pathogens and tumors...
- CD28/B7 costimulation: a reviewE A Greenfield
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Crit Rev Immunol 18:389-418. 1998..Thus, the B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses...
- B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cellsS Y Tseng
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Exp Med 193:839-46. 2001..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
- CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTLL L Lanier
Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, CA 94304
J Immunol 154:97-105. 1995..Therefore, the role of CD80 and CD86 in an immune response may be determined primarily by their differential expression on APC...
- Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatmentSylvaine You
Universite Paris Descartes, 75015 Paris, France
Proc Natl Acad Sci U S A 104:6335-40. 2007....
- Micropatterning of costimulatory ligands enhances CD4+ T cell functionKeyue Shen
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Proc Natl Acad Sci U S A 105:7791-6. 2008..With these patterns, we show that the peripheral presentation of CD28 has a larger impact on IL-2 secretion than CD3 colocalization/segregation...
- T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cellsAndreas E R Fasth
Rheumatology Unit, Center for Molecular Medicine L8 04, Karolinska University Hospital, Stockholm S 171 76, Sweden
J Immunol 183:4792-9. 2009..Our observations imply that CD28(null) T cells represent clinically important effector cells in dermatomyositis and polymyositis, and that HCMV might play a role in propagating disease in a subset of patients...
- Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycinLaura Strauss
Department of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 4:e5994. 2009..Here, we studied expansion, IL-2R-gamma chain signaling, survival pathways and resistance to apoptosis in human Treg responding to RAPA...
- The role of the CD28 receptor during T cell responses to antigenP S Linsley
Department of Cellular Immunology, Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
Annu Rev Immunol 11:191-212. 1993..The CD28 costimulatory receptor represents a novel target for immunosuppressive drugs...
- Programmed death-1 targeting can promote allograft survivalEngin Ozkaynak
Millennium Pharmaceuticals, Cambridge, MA 02139, USA
J Immunol 169:6546-53. 2002....
- Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonistsFred Luhder
Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Str 7, D 97078 Wurzburg, Germany
J Exp Med 197:955-66. 2003..Antibodies with this property may prove useful for the development of T cell stimulatory drugs...
- Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptorJohn Maher
Department of Human Genetics Medicine, Gene Transfer and Somatic Cell Engineering Laboratory, and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nat Biotechnol 20:70-5. 2002..These findings have important implications for adoptive immunotherapy of cancer, especially in the context of tumor cells that fail to express major histocompatibility complex antigens and co-stimulatory molecules...
- CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancersGilberto Filaci
Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
J Immunol 179:4323-34. 2007..Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer...
- CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsRichard V Parry
Abramson Family Cancer Research Institute, 556 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Cell Biol 25:9543-53. 2005..Together, these data suggest that CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms...
- Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40L S Walker
MRC Centre for Immune Regulation, University of Birmingham, UK
Immunol Today 21:333-7. 2000..Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles...
- The role of B7 costimulation in T-cell immunityN L Harris
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
Immunol Cell Biol 77:304-11. 1999..The present review outlines our current understanding of the physiological role of B7 costimulatory signals in regulating CD4+ T cell responses...
- Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infectionElisabeth Amyes
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, OX3 9DS Oxford, United Kingdom
J Exp Med 198:903-11. 2003..There are striking parallels in terms of the differentiation of CD8+ T cells specific for EBV and CMV. The results challenge current ideas on the definition of memory subsets...
- A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockadeA M Girvin
Department of Microbiology Immunology, Northwestern University Medical School, Northwestern University Institute for Neuroscience, Chicago, IL 60611, USA
J Immunol 164:136-43. 2000..Collectively, these results support a critical role for CD28 costimulation in EAE induction...
- A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activationMathias Maurer
Department of Neurology, Bayerische Julius Maximilians Universität, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
Immunogenetics 54:1-8. 2002..Our results suggest that the G allele at position +49 of exon 1 affects the CTLA4-driven down-regulation of T-cell activation and may be an important factor in the pathogenesis of autoimmune diseases...
- Regulatory functions of CD8+CD28- T cells in an autoimmune disease modelNader Najafian
Brigham and Women s Hospital, Boston, Massachusetts, USA
J Clin Invest 112:1037-48. 2003..These are the first data establishing that regulatory CD8+CD28- T cells occur in normal mice and play a critical role in disease resistance in CD28-/- animals...
- The immunological synapse and CD28-CD80 interactionsS K Bromley
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis MO, USA
Nat Immunol 2:1159-66. 2001....
- CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiationM Kubo
Division of Immunobiology, Research Institute for Biological Sciences, Science University of Tokyo, Noda City, Chiba, Japan
J Immunol 163:2432-42. 1999..This evidence of the enhancement of IL-4R sensitivity increases our understanding of how CD28 costimulation accelerates Th2 development...
- Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitisP J Perrin
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Immunol 163:1704-10. 1999..Therefore, the present results suggest a clinically relevant therapeutic scenario for human diseases, such as multiple sclerosis...
- CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligandK Saoulli
Department of Immunology, and Amgen Institute, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Exp Med 187:1849-62. 1998..Thus 4-1BB, via the TRAF2 molecule, can provide CD28-independent costimulatory signals to resting T cells...
- ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28A Hutloff
Molecular Immunology, Robert Koch Institut, Berlin, Germany
Nature 397:263-6. 1999..Our results indicate that ICOS is another major regulator of the adaptive immune system...
- Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromesBehnam Zal
Cardiological Sciences, St George s Hospital Medical School, London, UK
Circulation 109:1230-5. 2004..The triggers of activation and expansion of these cells to date remain unclear...
- CD28 costimulation promotes the production of Th2 cytokinesI C Rulifson
Ben May Institute for Cancer Research, Department of Pathology, University of Chicago, IL 60637, USA
J Immunol 158:658-65. 1997..Therefore, CD28 ligation promotes the production of Th2-type cytokines by naive murine T cells via an IL-4-dependent mechanism...
- Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulationNiklas Beyersdorf
University of Wurzburg, Institute for Virology and Immunobiology, Wurzburg, Germany
Immunology 119:441-50. 2006....
- Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunityLieping Chen
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Nat Rev Immunol 4:336-47. 2004
- CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patientsRoberto Gerli
Center for the Study of Rheumatic Diseases, Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico di Monteluce, I 06122 Perugia, Italy
Circulation 109:2744-8. 2004..However, the potential association between CD4+CD28null T cells and early atherosclerotic changes in RA has never been investigated...
- Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenesH W Mittrucker
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
J Immunol 167:5620-7. 2001..However, Ag-specific CD8(+) T cells generated in the absence of CD28 differentiated into normal effector and memory T cells...
- Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memoryM Suresh
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 167:5565-73. 2001..Therefore, CD28 signaling is not necessary for the proliferative renewal and maintenance of memory CD8 T cells...
- Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitisMichael Schirmer
Department of Internal Medicine, University of Innsbruck, Austria
Arthritis Res 4:71-6. 2002..032)...
- Detailed immunophenotype of CD8+ memory cytotoxic T-lymphocytes (CTL) against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigensJ V Giorgi
UCLA School of Medicine and the multicenter AIDS Cohort Study, Los Angeles, CA 90095 1745, USA
Immunol Lett 66:105-10. 1999....
- Differential T cell costimulatory requirements in CD28-deficient miceA Shahinian
Department of Medical Biophysics and Immunology, University of Toronto, Canada
Science 261:609-12. 1993..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
- CD4+CD28- costimulation-independent T cells in multiple sclerosisS Markovic-Plese
Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke (NINDS, NIH, 10 Center Drive, Bethesda, MD 20892-1400, USA
J Clin Invest 108:1185-94. 2001..The CD4+CD28- population is expanded in a subgroup of MS patients. Myelin basic protein-specific cells detected in this cell subset may play an important role in the inflammatory response within the central nervous system...
- Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapyNattawat Onlamoon
Department of Pathology and Lab Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Med Primatol 35:178-93. 2006..Our laboratory has previously shown that adoptive transfer of in vitro-expanded autologous purified polyclonal CD4(+) T cells using anti-CD3/CD28-coated beads induced antiviral responses capable of controlling SIV replication in vivo...
- The B7 family revisitedRebecca J Greenwald
Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Annu Rev Immunol 23:515-48. 2005..In this review, we revisit the roles of the B7:CD28 family members in regulating immune responses, and we discuss their therapeutic potential...
- Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cellsAlessio Delogu
Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Immunity 24:269-81. 2006....
- Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host diseaseNiklas Beyersdorf
University of Wurzburg, Institute for Virology and Immunobiology, Wurzburg, Germany
Blood 114:4575-82. 2009..Taken together, our data suggest that CD28-SA stimulation of bulk leukocyte cultures in vitro markedly increases the therapeutic window for adoptive immunotherapy with allogeneic T cells in vivo...
- CD28 as a molecular amplifier extending TCR ligation and signaling capabilitiesF Michel
Molecular Immunology Unit, Department of Immunology, Institut Pasteur, Paris, France
Immunity 15:935-45. 2001..These results should provide a conceptual framework for understanding quantitative and qualitative aspects of CD28-mediated costimulation...
- OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cellsP R Rogers
Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Immunity 15:445-55. 2001..Moreover, retroviral transduction of OX40-/- T cells with Bcl-xL or Bcl-2 reverses their survival defect. Thus, a temporal relationship exists between CD28 and OX40, with OX40 being a critical regulator of antigen-driven T cell survival...
- The CD28 signaling pathway regulates glucose metabolismKenneth A Frauwirth
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 16:769-77. 2002..These data suggest that CD28 costimulation functions to increase glycolytic flux, allowing T cells to anticipate energetic and biosynthetic needs associated with a sustained response...
- T-cell regulation by CD28 and CTLA-4M L Alegre
Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA
Nat Rev Immunol 1:220-8. 2001....
- It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activationLawrence P Kane
Dept of Medicine, The Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 9143 0795, USA
Trends Immunol 23:413-20. 2002..Although many questions remain, recent years have witnessed significant progress in understanding the signal transduction pathways leading from the TCR and CD28 to Rel/NF-kappaB-dependent transcription...
- CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2Xuguang Tai
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 6:152-62. 2005..Thus, CD28 costimulation directly signals developing thymocytes to express Foxp3 and to initiate the T(reg) cell differentiation program...
- The CD28-related molecule ICOS is required for effective T cell-dependent immune responsesA J Coyle
Department of Biology, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
Immunity 13:95-105. 2000..Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses...
- Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated miceTea Gogishvili
Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
PLoS ONE 4:e4643. 2009....
- Interaction of human PD-L1 and B7-1Manish J Butte
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Mol Immunol 45:3567-72. 2008..We show that PD-L1 is induced to a higher level on CD28high T cells than on CD28low T cells upon activation. These results suggest that PD-L1 may play an important and undervalued role on human T cells...
- Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritisJ H Yen
Department of Medicine and the Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Exp Med 193:1159-67. 2001..Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells...
- CD28 costimulation prevents cell death during primary T cell activationP J Noel
Department of Medicine, University of Chicago, IL 60637, USA
J Immunol 157:636-42. 1996..Thus, CD28 costimulation not only enhances the proliferative expansion of cells activated through the TCR but also increases the likelihood that individual cells survive during T cell activation...
- Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cellsMelissa R Snyder
Department of Medicine Rheumatology and Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 168:3839-46. 2002..The computer simulations favored a model in which KIR gene expression is inducible for a limited time during the initial stages of clonal expansion...
- T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1P S Linsley
Oncogen, Seattle, WA 98121
Proc Natl Acad Sci U S A 87:5031-5. 1990....
- Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathwaysA N Vallejo
Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Immunol 165:6301-7. 2000....
- Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitisT T Chang
Immunology Research Division, Department of Pathology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 190:733-40. 1999....
- Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formationLoïc Dupré
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
Immunity 17:157-66. 2002..These results demonstrate that WASP plays a central role in the movements of lipid rafts and identify a potential mechanism underlying the T cell defect affecting WAS patients...
- T cell co-stimulatory molecules other than CD28T H Watts
University of Toronto, Department of Immunology, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
Curr Opin Immunol 11:286-93. 1999....
- CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergenJ S Burr
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Respir Cell Mol Biol 24:563-8. 2001....
- CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assemblyRussell G Jones
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
J Exp Med 196:335-48. 2002..These findings provide a novel link between CD28 and an important apoptosis pathway in vivo, and demonstrate that PI3K/PKB signaling prevents apoptosis by inhibiting DISC assembly...
- Inhibitory CD8+ T cells in autoimmune diseaseMasakatsu Suzuki
The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
Hum Immunol 69:781-9. 2008..In essence, disease-specific approaches may be necessary to identify CD8(+) Ts optimally suited to treat immune dysfunctions in different autoimmune syndromes...
- Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient miceB Stoffel
Institute of Medical Microbiology and Hygiene, University of Cologne, Germany
Eur J Immunol 28:874-80. 1998..We conclude that ceramide generated by aSMase is not involved in CD28 signal transduction, but rather a perturbation of the secretory system is responsible for the impaired proliferation of aSMase-deficient splenocytes...
- CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosisP Lamprecht
Department of Rheumatology, University of Luebeck, 23538 Luebeck, Germany
Thorax 56:751-7. 2001..Lack of CD28 expression on peripheral blood CD4+ and CD8+ T cells has been reported in patients with Wegener's granulomatosis (WG), suggesting a pathogenetic role of CD28- T cells in WG...
- Ras/PI3kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulationUrban Sester
Institute for Immunology, Ruprecht Karls University, Heidelberg, Germany
Eur J Immunol 37:2881-91. 2007..Likewise, L-plastin is not phosphorylated. Thus, superagonistic CD28 stimulation does not mimic costimulation. Instead, it leads to a Ras/PI3Kinase/cofilin-independent state of "unpolarized T cell activation"...
- Interference with CD28, CD80, CD86 or CD152 in collagen-induced arthritis. Limited role of IFN-gamma in anti-B7-mediated suppression of diseaseA C Tellander
Active Biotech Research AB, SE-22007 Lund, Sweden
J Autoimmun 17:39-50. 2001..We also demonstrate that the enhanced production of IFN-gamma observed after B7-blockade is not accountable for the anti-B7 mediated inhibition of CIA...
- Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitisChristina Duftner
Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
Arthritis Res Ther 5:R292-300. 2003..MHC class I recognizing and activating natural killer cell receptors on the surface of CD4+CD28- T cells may be involved in a HLA-B27 mediated co-stimulation of these proinflammatory and cytotoxic cells...
- A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28Haruo Hanawa
Department of Microbiology and Immunology, The John P Robarts Research Institute, University of Western Ontario, 1400 Western Road, London, Ontario, Canada N6G 2V4
Blood 99:2138-45. 2002..These data demonstrate that CD28i, via noncovalent association with CD28, plays a role as a costimulatory signal amplifier in human T cells...
- Therapy with infliximab decreases the CD4+CD28- T cell compartment in peripheral blood in patients with rheumatoid arthritisAndrzej Pawlik
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111, Szczecin, ul Powst Wlkp 72, Poland
Rheumatol Int 24:351-4. 2004..The results suggest that TNFalpha-neutralizing therapy may restore T cell homeostasis and reduce expansion of the CD28- T cells, which are cytotoxic and may contribute to organ manifestations in RA...
- A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytesManisha Deshpande
National Centre for Cell Science, Ganeshkhind, Pune, India
Hum Immunol 63:20-3. 2002..In addition, we also report the occurence and sequence of a new CD28 mRNA isoform, one of the above eight, which is a novel variant generated by the use of a new combination of splice donor and acceptor sites...
- CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytesJoy A Williams
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:2759-65. 2002....
- Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanismsJ D zur Hausen
Roche Research Center, Hoffmann La Roche Inc, Nutley, USA
Eur J Immunol 27:2643-9. 1997..CD28 co-localizes with Fyn molecules that contain the N terminus and a functional SH2 domain. These results suggest that Fyn association with the TCR-CD3 complex, CD45 and CD28 is mediated by different molecular mechanisms...
- Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytesH Nishina
Amgen Institute and Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, M5G 2C1 Toronto, Ontario, Canada
J Exp Med 186:941-53. 1997..Our data provide the first genetic evidence that SEK1 is an important effector molecule that relays CD28 signaling to IL-2 production and T cell proliferation...
- CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune responseW C Gause
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 158:4082-7. 1997..polygyrus-inoculated mice, and elevations in both serum IgG1 and IgE levels occur. These results indicate that the specific kind of type 2 immune response determines whether T cell differentiation to IL-4 production is CD28 dependent...
- CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell toleranceT L Walunas
Ben May Institute, University of Chicago, IL 60637, USA
J Immunol 156:1006-13. 1996..Therefore, it appears that CD28, although not essential for the selection of T cells during development, may allow for additional signals that increase the efficiency of selection and/or expansion of peripheral T cell populations...
- CTLA4 mediates antigen-specific apoptosis of human T cellsJ G Gribben
Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA 02115
Proc Natl Acad Sci U S A 92:811-5. 1995..This function appears to be antigen-restricted, since a concomitant signal T-cell receptor signal is required. Regulation of this pathway may provide a novel therapeutic strategy to delete antigen-specific activated T cells...
- Functional disruption of the CD28 gene transcriptional initiator in senescent T cellsA N Vallejo
Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 276:2565-70. 2001..Rather, initiators can have a direct role in regulating the expression of specific genes. The gain or loss of initiator activity can be an important determinant of cell phenotypes...
- Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol esterM Tacke
Institute for Virology and Immunobiology, University of Wurzburg, Germany
J Immunol 154:5121-7. 1995....
- Timing and casting for actors of thymic negative selectionN Dautigny
Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
J Immunol 162:1294-302. 1999..Finally, we show involvement in opposing directions for p59fyn and SHP-1 molecules in signaling for thymic negative selection...
- Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donorsW Li
Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, E1540 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, Pennsylvania, 15213, USA
Transplantation 72:1423-32. 2001....
- Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokinesL P Kane
Department of Medicine, University of California, San Francisco, CA 94143, USA
Nat Immunol 2:37-44. 2001..Our results provide evidence that CD28 costimulation of different cytokines is mediated by discrete signaling pathways, one of which includes Akt...
- Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28W J Metzler
Nat Struct Biol 4:527-31. 1997..Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site...
- T-cell immunity in acute coronary syndromesC M Weyand
Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 76:1011-20. 2001..Natural killer T cells have proinflammatory properties and the capability of directly contributing to vascular injury...
- Structure of murine CTLA-4 and its role in modulating T cell responsivenessD A Ostrov
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Science 290:816-9. 2000..This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness...
- Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulationY Harada
Research Institute for Biological Sciences, Science University of Tokyo, 2669 Yamazaki, Noda, Chiba 278-0022, Japan
J Biol Chem 276:9003-8. 2001..Taken together, these data indicate that PI3K, when associated with the YMNM motif, may act as a negative mediator in CD28-mediated IL-2 gene transcription...
- T Cell Replicative Senescence & Bone Loss During AgingRita Effros; Fiscal Year: 2005....
- Mechanisms by which selenium influences T helper cells during immune responsesPeter R Hoffmann; Fiscal Year: 2010..The goal of this project is to determine the mechanisms by which this potent antioxidant affects the immune system with the intent of providing an important step toward optimal use of Se supplementation. ..
- IMMUNE FACTORS IN PEDIATRIC LONG-TERM HIV SURVIVORSWilliam Shearer; Fiscal Year: 1999....
- CD8 T Cell Interaction with Bone Cells in HIV DiseaseRita Effros; Fiscal Year: 2005..abstract_text> ..
- Conference on the Biology of AgingRita Effros; Fiscal Year: 2007..The dissemination of information that is useful for maintaining the health and vitality of this age group will have a significant impact on the quality of life of a large number of Americans. [unreadable] [unreadable] [unreadable]..
- CD8 T Cell Replicative Senescence & HIV DiseaseRita Effros; Fiscal Year: 2008..This novel approach to analysis of the immune exhaustion in HIV disease may yield promising strategies for immunotherapy to retard or prevent progression to AIDS. ..
- CD8 T Cell Replicative Senescence: Impact on Aged HumansRita Effros; Fiscal Year: 2009..abstract_text> ..
- Conf on Mechanism and Applications of Immune ToleranceJeffrey Bluestone; Fiscal Year: 2002..Finally, specific talks in immunotherapy of autoimmunity, transplantation, cancer and infectious disease will be included. ..
- Expansion of HIV infected T cells for immunotherapyJames Riley; Fiscal Year: 2005..Successful completion of these aims will pave the way for second generation autologous transfusion trials in which the ability of selected subsets of expanded T cells to fight opportunistic and HIV infection(s) can be measured. ..
- Regulation of human T cell activation by the CD28 familyJames Riley; Fiscal Year: 2008..The data generated from these studies will better define the relationship between antigen dependent and independent signals and enable new strategies to modulate T cell activation for therapeutic applications. ..
- Development of tumor based antigen presenting cellsJames Riley; Fiscal Year: 2008..Furthermore, these studies will provide the foundation for conducting a clinical trial. ..
- Lentiviral Redirected T Cells for B Cancer ImmunotherapyJames Riley; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Role of Notch 1 in Immune ToleranceJeffrey Bluestone; Fiscal Year: 2005..To Identify the biochemical, cellular and genetic effects of Notch signaling in T cells; and Specific Aim #2. In vivo application of Notch signaling for the establishment of peripheral T cell tolerance. ..
- Identifying T cell ligands in sarcoidosisANDREW FONTENOT; Fiscal Year: 2005..This novel approach will generate "mimotopes" which can be screened against known peptide/protein sequences and will provide new insight into the etiologic sarcoidosis antigen. ..
- PATHOGENIC T CELLS IN BERYLLIUM-INDUCED LUNG DISEASEANDREW FONTENOT; Fiscal Year: 2002..Additional studies will examine whether antigen processing is required for stimulation of these T cell hybridomas. Together, these studies will provide new insight into the immunopathogenesis of CBD and other granulomatous disorders. ..
- BLyS, APRIL and antibody production in HIV infectionAndrea Cerutti; Fiscal Year: 2004..Aim 1. To analyze the mechanisms by which HIV up-regulates BLyS and APRIL in APCs. Aim 2. To analyze the role of BLyS and APRIL in the modulation of HIV-induced antibody production. ..
- ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITISAndrea Cerutti; Fiscal Year: 2003..In addition to elucidating the pathogenesis of RA, the experiments outlined in this application should allow to devise new strategies aimed at reducing the production of pathogenic antibodies, including rheumatoid factors. ..
- Pre-Conditioning Pancreatic Islets for TransplantationGinny Bumgardner; Fiscal Year: 2006..The effect of oxygen pre-conditioning on islet viability and function in vivo will be determined using fluorescence microscopy and the marginal mass model of islet transplantation. ..
- Immunological control of a persistent viral infectionSally R Sarawar; Fiscal Year: 2010..The results obtained may have broader significance in understanding the mechanisms controlling T cell activation or tolerance, in general. ..
- Role of T cells in self-limited mucosal infectionsLynn Bry; Fiscal Year: 2006..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
- Premature Atherosclerosis in Rheumatic DiseasesMARY CROW; Fiscal Year: 2006..abstract_text> ..
- CD80 binding peptides as therapeutic agents in arthritisMythily Srinivasan; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Iron Deficiency and Anemia in HIV and HCV-Infected WomenRichard Semba; Fiscal Year: 2005..S. and elsewhere. ..
- Crimson - i2b2 integration for high-throughput, scalable sample collectionLynn Bry; Fiscal Year: 2010....
- Negative regulation of TCR-associated PTKsROBERT RICKERT; Fiscal Year: 2007..These issues are important for our understanding of the molecular machinery of T cell activation and the immune response. ..
- Role of memory T cell dynamics in SIV infectionLouis Picker; Fiscal Year: 2007..abstract_text> ..
- Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older WomenRichard Semba; Fiscal Year: 2008..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
- HOST DEFENSE TO NEONATAL INRACELLULAR PATHOGENSChristopher Wilson; Fiscal Year: 2008..These studies will provide insights into mechanisms for host defense against Lm and for the greater susceptibility of the neonate to this and related intracellular bacterial pathogens. ..
- EXPERIMENTAL THERAPY OF CANCER BY COSTIMULATED IMMUNITYLieping Chen; Fiscal Year: 2010..Finally, we will develop and characterize human B7-DC* and PD-1 mAb as a first step towards translation of laboratory study to clinic. Our studies will form the foundation for new approaches towards immunotherapy of cancers. ..
- Pathways of T cell SenescenceABBE DE VALLEJO; Fiscal Year: 2009....
- Development of RhCMV Vectors for SIV InfectionLouis Picker; Fiscal Year: 2009..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
- Gene expression abnormalities in mycosis fungoidesHenry Wong; Fiscal Year: 2007..3. To study whether the expression of these genes are altered by therapy in vitro and in vivo. [unreadable] [unreadable] [unreadable] [unreadable]..
- Interaction between influenza virus and H. influenzaeSally Sarawar; Fiscal Year: 2007..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
- MERCURY INDUCED AUTOIMMUNITYKenneth Pollard; Fiscal Year: 2007..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
- A novel substrate of Syk-family PTKsROBERT RICKERT; Fiscal Year: 2007..These experiments will ask how the absence (or severe reduction) of VHR affects TCR-induced activation of MAP kinases, T cell proliferation, effector functions and immune responses in whole animals. ..
- BIOCHEMICAL ANALYSIS OF IMMUNOLOGICAL MEMORYDONNA FARBER; Fiscal Year: 2007..abstract_text> ..
- The Fourth International Leukocyte Signal Transduction Workshop: Clinical ImplicaAmnon Altman; Fiscal Year: 2007..abstract_text> ..
- FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATIONAmnon Altman; Fiscal Year: 2005....
- MACROPHAGE MEDIATED IMMUNOREGULATION VIA TRYPTOPHANDavid Munn; Fiscal Year: 2002..These studies will define a fundamental and previously unsuspected mechanism of T cell regulation imposed by cells of the innate immune system. ..
- IMMUNOTOXICOLOGY OF A HEAVY METALKenneth Pollard; Fiscal Year: 2004..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
- DNA METHYLATION IN T CELL DEVELOPMENT AND FUNCTIONChristopher Wilson; Fiscal Year: 2004..2) The increased numbers of TCRgammabeta thymocytes will reflect either increased locus accessibility and rearrangement of the relevant gammabeta TCR genes or reduced Notch signaling. ..
- DIETARY FATTY CONTROL OF INFLAMMATIONKevin High; Fiscal Year: 2002..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
- THYMIC SELECTION AND T CELL LINEAGE COMMITMENTLeslie Berg; Fiscal Year: 2003..This information could enhance our understanding of T cell recognition and the establishment of self-tolerance. ..
- Novel strategies to prevent islet transplantation rejec*Lieping Chen; Fiscal Year: 2003..It is anticipated that these studies will provide a foundation to develop new approaches for islet transplantation and facilitate the treatment of type 1 diabetes mellitus. ..
- CD45 REGULATION OF T LYMPHOCYTE ACTIVATIONDavid Leitenberg; Fiscal Year: 2003..In addition basic studies on the regulation of T cell activation have broad applicability to fields of cancer pathogenesis, autoimmunity, and infectious disease. ..
- PKC theta in the Immune Synapse and T Cell AnergyAmnon Altman; Fiscal Year: 2003..They offer the potential for developing novel therapeutic strategies, which may be useful for modulating CD28 costimulation in disease. ..
- Immunoregulation in EAE and novel costimulatory pathwaysSamia Khoury; Fiscal Year: 2002..We will also study the in vivo mechanisms of the novel costimulatory pathways by adoptive transfer of STAT4 KO/TCR transgenic or STAT4 KO/TCR transgenic cells into WT or TCRalphabeta KO recipients. ..
- IN VIVO FUNCTION OF THE B7 FAMILY OF COSTIMULATORSArlene Sharpe; Fiscal Year: 2004..These studies may thereby assist in the design of optimal therapeutic strategies for manipulation of the B7- CD28/CTLA-4 pathway and also indicate the therapeutic potential of ICOS pathway manipulation. ..
- HIV ENV & MACROPHAGE CHEMOKINE RECEPTOR IONIC SIGNALINGBruce Freedman; Fiscal Year: 2004....
- Protective role of cross-reactive anti-enteric antibodyLynn Bry; Fiscal Year: 2005....
- CD40L IN ALLOGRAFT TOLERANCE AND VIRAL IMMUNITYRichard Pierson; Fiscal Year: 2001..Finally, this study will investigate the potential of CD40L inhibition to induce prolonged acceptance of a transplanted organ, and may contribute to development of clinically relevant approaches to the induction of tolerance. ..
- Role of Ikaros in IL-2 gene expression and T cell anergyAndrew Wells; Fiscal Year: 2005..Therefore, the studies proposed are consistent with the exploratory nature of the R21 mechanism. ..
- CD4 Regulator T Cells Suppress Alloreactivity after BMTBryon Johnson; Fiscal Year: 2005..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
- COACTIVATION SIGNALS REGULATE THYMOCYTE DEVELOPMENTDavid McKean; Fiscal Year: 2005..These analyses will determine how signals integrated from different co-inducer receptors stimulate cross-talk between signaling pathways that affects the outcome of thymocyte selection. ..
- IONIC CONDUCTANCES AND CD4 LYMPHOCYTE DIFFERENTIATIONBruce Freedman; Fiscal Year: 2001..The central hypothesis of this proposal is that the TCR-mediated calcium response regulates CD4plus lymphocyte differentiation, and that Kv channel regulate the secondary responses of differentiated cells to antigen. ..
- HEMATOPOIETIC TYROSINE PHOSPHATASE (HEPTP) IN T CELLSTomas Mustelin; Fiscal Year: 2004..This study will thoroughly illuminate the biology of HePTP. The new information will be useful for the design of therapies to treat a variety of hematological diseases such as myelodysplastic syndrome, T cell leukemias and lymphomas. ..
- GLOBIN GENE TRANSFER FOR THERAPY OF SICKLE CELL ANEMIAMichel Sadelain; Fiscal Year: 2004....
- IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMAJeffrey Weber; Fiscal Year: 2003....
- CTLA-4 Inhibition and Autoimmunity in MelanomaJeffrey Weber; Fiscal Year: 2008..abstract_text> ..
- Memory CD4 T cell-mediated immunopathology in influenza infectionDONNA FARBER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- NOVEL THERAPEUTIC TARGETS IN RHEUMATOID ARTHRITISEUGENE ST CLAIR; Fiscal Year: 2003..St.Clair with outstanding clinical research opportunities and educational experiences for his trainees. ..
- Dendritic Cell Vaccination During Lymphoid ReconstitutionJeffrey Weber; Fiscal Year: 2008..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
- HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIAJeffrey Weber; Fiscal Year: 2003..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
- IL-12 as an Adjuvant for a Melanoma Peptide VaccineJeffrey Weber; Fiscal Year: 2003..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
- Abatacept Vs TNF Blockade in Early Rheumatoid ArthritisEUGENE ST CLAIR; Fiscal Year: 2007..The proposed clinical trial will compare the remission-inducing capabilities of two novel therapies for early RA, and search for biomarkers that predict treatment response. [unreadable] [unreadable] [unreadable] [unreadable]..
- ROLE OF ICOS IN T CELL RESPONSES AND ANTI-TUMOR IMMUNITYGordon Freeman; Fiscal Year: 2004..To examine the expression the expression of ICOS counter-receptor on APC and characterize its molecular structure. SPECIFIC AIM 3. To examine how blocking ICOS signals affect the immune response to murine tumors. ..
- THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCECharles Cook; Fiscal Year: 2007..In general, these studies will explore the immunobiology of murine allograft acceptance, and its relationship to allograft tolerance. ..
- Restraint stress-induced neurogenic bladder inflammationTheoharis Theoharides; Fiscal Year: 2006..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
- CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL ATheoharis Theoharides; Fiscal Year: 2001..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
- Mast cells, antidepressants and chronic fatigue syndromeTheoharis Theoharides; Fiscal Year: 2007..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
- HLA-DO in Immunity and AutoimmunityXinjian Chen; Fiscal Year: 2004..abstract_text> ..
- Mutations in PKA gene transcripts of lupus T cellsDama Laxminarayana; Fiscal Year: 2007..abstract_text> ..
- Heterogeneous Subsets of Memory CD4 T cellsDONNA FARBER; Fiscal Year: 2007..This research proposal will therefore address the basic mechanisms underlying memory T cell heterogeneity, using novel cellular immunologic and molecular approaches. ..