cd28 antigens

Summary

Summary: T-cell differentiation antigens that serve as the receptors for the B7 antigen (ANTIGENS, CD80) which modulates T-cell lymphokine production.

Top Publications

  1. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
  2. ncbi CD28/B7 system of T cell costimulation
    D J Lenschow
    Committee on Immunology, Ben May Institute, Chicago, Illinois 60637, USA
    Annu Rev Immunol 14:233-58. 1996
  3. ncbi The interaction properties of costimulatory molecules revisited
    Alison V Collins
    Nuffield Department of Clinical Medicine, The University of Oxford, John Radcliffe Hospital, Headington, United Kingdom
    Immunity 17:201-10. 2002
  4. ncbi CD28-mediated co-stimulation: a quantitative support for TCR signalling
    Oreste Acuto
    Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, Cedex 15, 75724 Paris, France
    Nat Rev Immunol 3:939-51. 2003
  5. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
  6. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
  7. ncbi Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    Ganesh Suntharalingam
    Department of Intensive Care Medicine, Northwick Park and St Mark s Hospital, Harrow, London, United Kingdom
    N Engl J Med 355:1018-28. 2006
  8. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
  9. ncbi Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells
    D J Fowell
    Department of Medicine, University of California San Francisco 94143, USA
    Immunity 11:399-409. 1999
  10. ncbi Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    Jason M Brenchley
    Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:2711-20. 2003

Detail Information

Publications261 found, 100 shown here

  1. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
    ..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
  2. ncbi CD28/B7 system of T cell costimulation
    D J Lenschow
    Committee on Immunology, Ben May Institute, Chicago, Illinois 60637, USA
    Annu Rev Immunol 14:233-58. 1996
    ..It is our hope and expectation that this review will provoke additional research that will unravel this important, yet complex, signaling pathway...
  3. ncbi The interaction properties of costimulatory molecules revisited
    Alison V Collins
    Nuffield Department of Clinical Medicine, The University of Oxford, John Radcliffe Hospital, Headington, United Kingdom
    Immunity 17:201-10. 2002
    ..We propose that the distinct structures and binding properties of B7-1 and B7-2 account for their overlapping but distinct effects on T cell responses...
  4. ncbi CD28-mediated co-stimulation: a quantitative support for TCR signalling
    Oreste Acuto
    Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, Cedex 15, 75724 Paris, France
    Nat Rev Immunol 3:939-51. 2003
  5. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  6. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
    ..The implications of these complexities and the potential for use of these therapies in clinical immune intervention are discussed...
  7. ncbi Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    Ganesh Suntharalingam
    Department of Intensive Care Medicine, Northwick Park and St Mark s Hospital, Harrow, London, United Kingdom
    N Engl J Med 355:1018-28. 2006
    ..Documentation of the clinical course occurring over the 30 days after infusion offers insight into the systemic inflammatory response syndrome in the absence of contaminating pathogens, endotoxin, or underlying disease...
  8. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
    ..Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation-induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse...
  9. ncbi Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells
    D J Fowell
    Department of Medicine, University of California San Francisco 94143, USA
    Immunity 11:399-409. 1999
    ..Development of protective Th1 cells was unimpeded. These data define a nonredundant role for Itk in modulating signals from the TCR/CD28 pathways that are specific for the establishment of stable IL-4 but not IFNgamma expression...
  10. ncbi Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    Jason M Brenchley
    Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:2711-20. 2003
    ..Thus, our studies define a phenotype associated with replicative senescence in HIV-specific CD8(+) T cells, which may have broad implications to other conditions associated with chronic antigenic stimulation...
  11. pmc Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
    Niklas Beyersdorf
    Institute for Virology and Immunobiology, University of Wurzburg, D 97078 Wurzburg, Germany
    J Exp Med 202:445-55. 2005
    ..Our data indicate that this class of CD28-specific monoclonal antibodies targets CD4+CD25+ T reg cells and provides a novel means for the effective treatment of multiple sclerosis and other autoimmune diseases...
  12. ncbi CD28nullCD4+ T cells--characterization of an effector memory T-cell population in patients with rheumatoid arthritis
    A E R Fasth
    Rheumatology Unit, Department of Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Scand J Immunol 60:199-208. 2004
    ....
  13. pmc NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
    N Coudronniere
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 97:3394-9. 2000
    ..These findings identify a unique PKCtheta-mediated pathway for the costimulatory action of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade...
  14. ncbi 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
    J T Tan
    The Carlos and Marguerite Mason Transplantation Biology Research Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 163:4859-68. 1999
    ....
  15. ncbi B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    B Salomon
    Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 12:431-40. 2000
    ..The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases...
  16. pmc The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian University of Medicine, Szczecin, Poland
    Arthritis Res Ther 5:R210-3. 2003
    ..The results suggest that the frequency of CD4+CD28- T cells may be a marker correlating with extra-articular manifestations and joint involvement...
  17. ncbi Identification and distribution of the costimulatory receptor CD28 in the mouse
    J A Gross
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    J Immunol 149:380-8. 1992
    ..The potent costimulatory function of CD28 on mature T cells, together with the high level of expression on CD4+8+ thymocytes, suggest that this costimulatory receptor might play an important role in T cell development and activation...
  18. ncbi Functional properties of CD4+ CD28- T cells in the aging immune system
    C M Weyand
    Mayo Clinic, Rochester, MN 55905, USA
    Mech Ageing Dev 102:131-47. 1998
    ..We propose that the emergence of CD28-deficient CD4 T cells in the elderly can partially explain age-specific aberrations in immune responsiveness...
  19. ncbi Memory CD8+ T cells require CD28 costimulation
    Annie B Borowski
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 179:6494-503. 2007
    ..These findings also raise questions about the efficacy of CD8(+) T cell-based vaccines against such pathogens and tumors...
  20. ncbi CD28/B7 costimulation: a review
    E A Greenfield
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Crit Rev Immunol 18:389-418. 1998
    ..Thus, the B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses...
  21. pmc B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    S Y Tseng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 193:839-46. 2001
    ..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
  22. ncbi CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL
    L L Lanier
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, CA 94304
    J Immunol 154:97-105. 1995
    ..Therefore, the role of CD80 and CD86 in an immune response may be determined primarily by their differential expression on APC...
  23. pmc Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    Sylvaine You
    Universite Paris Descartes, 75015 Paris, France
    Proc Natl Acad Sci U S A 104:6335-40. 2007
    ....
  24. pmc Micropatterning of costimulatory ligands enhances CD4+ T cell function
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7791-6. 2008
    ..With these patterns, we show that the peripheral presentation of CD28 has a larger impact on IL-2 secretion than CD3 colocalization/segregation...
  25. ncbi T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells
    Andreas E R Fasth
    Rheumatology Unit, Center for Molecular Medicine L8 04, Karolinska University Hospital, Stockholm S 171 76, Sweden
    J Immunol 183:4792-9. 2009
    ..Our observations imply that CD28(null) T cells represent clinically important effector cells in dermatomyositis and polymyositis, and that HCMV might play a role in propagating disease in a subset of patients...
  26. pmc Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
    Laura Strauss
    Department of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e5994. 2009
    ..Here, we studied expansion, IL-2R-gamma chain signaling, survival pathways and resistance to apoptosis in human Treg responding to RAPA...
  27. ncbi The role of the CD28 receptor during T cell responses to antigen
    P S Linsley
    Department of Cellular Immunology, Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    Annu Rev Immunol 11:191-212. 1993
    ..The CD28 costimulatory receptor represents a novel target for immunosuppressive drugs...
  28. ncbi Programmed death-1 targeting can promote allograft survival
    Engin Ozkaynak
    Millennium Pharmaceuticals, Cambridge, MA 02139, USA
    J Immunol 169:6546-53. 2002
    ....
  29. pmc Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists
    Fred Luhder
    Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Str 7, D 97078 Wurzburg, Germany
    J Exp Med 197:955-66. 2003
    ..Antibodies with this property may prove useful for the development of T cell stimulatory drugs...
  30. ncbi Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor
    John Maher
    Department of Human Genetics Medicine, Gene Transfer and Somatic Cell Engineering Laboratory, and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Biotechnol 20:70-5. 2002
    ..These findings have important implications for adoptive immunotherapy of cancer, especially in the context of tumor cells that fail to express major histocompatibility complex antigens and co-stimulatory molecules...
  31. ncbi CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers
    Gilberto Filaci
    Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    J Immunol 179:4323-34. 2007
    ..Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer...
  32. pmc CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    Richard V Parry
    Abramson Family Cancer Research Institute, 556 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:9543-53. 2005
    ..Together, these data suggest that CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms...
  33. ncbi Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
    L S Walker
    MRC Centre for Immune Regulation, University of Birmingham, UK
    Immunol Today 21:333-7. 2000
    ..Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles...
  34. ncbi The role of B7 costimulation in T-cell immunity
    N L Harris
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Immunol Cell Biol 77:304-11. 1999
    ..The present review outlines our current understanding of the physiological role of B7 costimulatory signals in regulating CD4+ T cell responses...
  35. pmc Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection
    Elisabeth Amyes
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, OX3 9DS Oxford, United Kingdom
    J Exp Med 198:903-11. 2003
    ..There are striking parallels in terms of the differentiation of CD8+ T cells specific for EBV and CMV. The results challenge current ideas on the definition of memory subsets...
  36. ncbi A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade
    A M Girvin
    Department of Microbiology Immunology, Northwestern University Medical School, Northwestern University Institute for Neuroscience, Chicago, IL 60611, USA
    J Immunol 164:136-43. 2000
    ..Collectively, these results support a critical role for CD28 costimulation in EAE induction...
  37. ncbi A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation
    Mathias Maurer
    Department of Neurology, Bayerische Julius Maximilians Universität, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Immunogenetics 54:1-8. 2002
    ..Our results suggest that the G allele at position +49 of exon 1 affects the CTLA4-driven down-regulation of T-cell activation and may be an important factor in the pathogenesis of autoimmune diseases...
  38. pmc Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    Nader Najafian
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 112:1037-48. 2003
    ..These are the first data establishing that regulatory CD8+CD28- T cells occur in normal mice and play a critical role in disease resistance in CD28-/- animals...
  39. ncbi The immunological synapse and CD28-CD80 interactions
    S K Bromley
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis MO, USA
    Nat Immunol 2:1159-66. 2001
    ....
  40. ncbi CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation
    M Kubo
    Division of Immunobiology, Research Institute for Biological Sciences, Science University of Tokyo, Noda City, Chiba, Japan
    J Immunol 163:2432-42. 1999
    ..This evidence of the enhancement of IL-4R sensitivity increases our understanding of how CD28 costimulation accelerates Th2 development...
  41. ncbi Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis
    P J Perrin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Immunol 163:1704-10. 1999
    ..Therefore, the present results suggest a clinically relevant therapeutic scenario for human diseases, such as multiple sclerosis...
  42. pmc CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
    K Saoulli
    Department of Immunology, and Amgen Institute, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Exp Med 187:1849-62. 1998
    ..Thus 4-1BB, via the TRAF2 molecule, can provide CD28-independent costimulatory signals to resting T cells...
  43. ncbi ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    A Hutloff
    Molecular Immunology, Robert Koch Institut, Berlin, Germany
    Nature 397:263-6. 1999
    ..Our results indicate that ICOS is another major regulator of the adaptive immune system...
  44. ncbi Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes
    Behnam Zal
    Cardiological Sciences, St George s Hospital Medical School, London, UK
    Circulation 109:1230-5. 2004
    ..The triggers of activation and expansion of these cells to date remain unclear...
  45. ncbi CD28 costimulation promotes the production of Th2 cytokines
    I C Rulifson
    Ben May Institute for Cancer Research, Department of Pathology, University of Chicago, IL 60637, USA
    J Immunol 158:658-65. 1997
    ..Therefore, CD28 ligation promotes the production of Th2-type cytokines by naive murine T cells via an IL-4-dependent mechanism...
  46. pmc Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation
    Niklas Beyersdorf
    University of Wurzburg, Institute for Virology and Immunobiology, Wurzburg, Germany
    Immunology 119:441-50. 2006
    ....
  47. ncbi Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    Lieping Chen
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Rev Immunol 4:336-47. 2004
  48. ncbi CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients
    Roberto Gerli
    Center for the Study of Rheumatic Diseases, Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico di Monteluce, I 06122 Perugia, Italy
    Circulation 109:2744-8. 2004
    ..However, the potential association between CD4+CD28null T cells and early atherosclerotic changes in RA has never been investigated...
  49. ncbi Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 167:5620-7. 2001
    ..However, Ag-specific CD8(+) T cells generated in the absence of CD28 differentiated into normal effector and memory T cells...
  50. ncbi Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory
    M Suresh
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 167:5565-73. 2001
    ..Therefore, CD28 signaling is not necessary for the proliferative renewal and maintenance of memory CD8 T cells...
  51. pmc Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitis
    Michael Schirmer
    Department of Internal Medicine, University of Innsbruck, Austria
    Arthritis Res 4:71-6. 2002
    ..032)...
  52. ncbi Detailed immunophenotype of CD8+ memory cytotoxic T-lymphocytes (CTL) against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigens
    J V Giorgi
    UCLA School of Medicine and the multicenter AIDS Cohort Study, Los Angeles, CA 90095 1745, USA
    Immunol Lett 66:105-10. 1999
    ....
  53. ncbi Differential T cell costimulatory requirements in CD28-deficient mice
    A Shahinian
    Department of Medical Biophysics and Immunology, University of Toronto, Canada
    Science 261:609-12. 1993
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
  54. pmc CD4+CD28- costimulation-independent T cells in multiple sclerosis
    S Markovic-Plese
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke (NINDS, NIH, 10 Center Drive, Bethesda, MD 20892-1400, USA
    J Clin Invest 108:1185-94. 2001
    ..The CD4+CD28- population is expanded in a subgroup of MS patients. Myelin basic protein-specific cells detected in this cell subset may play an important role in the inflammatory response within the central nervous system...
  55. ncbi Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy
    Nattawat Onlamoon
    Department of Pathology and Lab Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Med Primatol 35:178-93. 2006
    ..Our laboratory has previously shown that adoptive transfer of in vitro-expanded autologous purified polyclonal CD4(+) T cells using anti-CD3/CD28-coated beads induced antiviral responses capable of controlling SIV replication in vivo...
  56. ncbi The B7 family revisited
    Rebecca J Greenwald
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 23:515-48. 2005
    ..In this review, we revisit the roles of the B7:CD28 family members in regulating immune responses, and we discuss their therapeutic potential...
  57. ncbi Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells
    Alessio Delogu
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 24:269-81. 2006
    ....
  58. ncbi Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease
    Niklas Beyersdorf
    University of Wurzburg, Institute for Virology and Immunobiology, Wurzburg, Germany
    Blood 114:4575-82. 2009
    ..Taken together, our data suggest that CD28-SA stimulation of bulk leukocyte cultures in vitro markedly increases the therapeutic window for adoptive immunotherapy with allogeneic T cells in vivo...
  59. ncbi CD28 as a molecular amplifier extending TCR ligation and signaling capabilities
    F Michel
    Molecular Immunology Unit, Department of Immunology, Institut Pasteur, Paris, France
    Immunity 15:935-45. 2001
    ..These results should provide a conceptual framework for understanding quantitative and qualitative aspects of CD28-mediated costimulation...
  60. ncbi OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    P R Rogers
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 15:445-55. 2001
    ..Moreover, retroviral transduction of OX40-/- T cells with Bcl-xL or Bcl-2 reverses their survival defect. Thus, a temporal relationship exists between CD28 and OX40, with OX40 being a critical regulator of antigen-driven T cell survival...
  61. ncbi The CD28 signaling pathway regulates glucose metabolism
    Kenneth A Frauwirth
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 16:769-77. 2002
    ..These data suggest that CD28 costimulation functions to increase glycolytic flux, allowing T cells to anticipate energetic and biosynthetic needs associated with a sustained response...
  62. ncbi T-cell regulation by CD28 and CTLA-4
    M L Alegre
    Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA
    Nat Rev Immunol 1:220-8. 2001
    ....
  63. ncbi It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation
    Lawrence P Kane
    Dept of Medicine, The Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 9143 0795, USA
    Trends Immunol 23:413-20. 2002
    ..Although many questions remain, recent years have witnessed significant progress in understanding the signal transduction pathways leading from the TCR and CD28 to Rel/NF-kappaB-dependent transcription...
  64. ncbi CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    Xuguang Tai
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 6:152-62. 2005
    ..Thus, CD28 costimulation directly signals developing thymocytes to express Foxp3 and to initiate the T(reg) cell differentiation program...
  65. ncbi The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
    A J Coyle
    Department of Biology, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Immunity 13:95-105. 2000
    ..Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses...
  66. pmc Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice
    Tea Gogishvili
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 4:e4643. 2009
    ....
  67. pmc Interaction of human PD-L1 and B7-1
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Immunol 45:3567-72. 2008
    ..We show that PD-L1 is induced to a higher level on CD28high T cells than on CD28low T cells upon activation. These results suggest that PD-L1 may play an important and undervalued role on human T cells...
  68. pmc Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis
    J H Yen
    Department of Medicine and the Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Exp Med 193:1159-67. 2001
    ..Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells...
  69. ncbi CD28 costimulation prevents cell death during primary T cell activation
    P J Noel
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 157:636-42. 1996
    ..Thus, CD28 costimulation not only enhances the proliferative expansion of cells activated through the TCR but also increases the likelihood that individual cells survive during T cell activation...
  70. ncbi Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells
    Melissa R Snyder
    Department of Medicine Rheumatology and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 168:3839-46. 2002
    ..The computer simulations favored a model in which KIR gene expression is inducible for a limited time during the initial stages of clonal expansion...
  71. pmc T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    P S Linsley
    Oncogen, Seattle, WA 98121
    Proc Natl Acad Sci U S A 87:5031-5. 1990
    ....
  72. ncbi Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways
    A N Vallejo
    Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 165:6301-7. 2000
    ....
  73. pmc Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
    T T Chang
    Immunology Research Division, Department of Pathology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 190:733-40. 1999
    ....
  74. ncbi Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation
    Loïc Dupré
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Immunity 17:157-66. 2002
    ..These results demonstrate that WASP plays a central role in the movements of lipid rafts and identify a potential mechanism underlying the T cell defect affecting WAS patients...
  75. ncbi T cell co-stimulatory molecules other than CD28
    T H Watts
    University of Toronto, Department of Immunology, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Curr Opin Immunol 11:286-93. 1999
    ....
  76. ncbi CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergen
    J S Burr
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Respir Cell Mol Biol 24:563-8. 2001
    ....
  77. pmc CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly
    Russell G Jones
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
    J Exp Med 196:335-48. 2002
    ..These findings provide a novel link between CD28 and an important apoptosis pathway in vivo, and demonstrate that PI3K/PKB signaling prevents apoptosis by inhibiting DISC assembly...
  78. pmc Inhibitory CD8+ T cells in autoimmune disease
    Masakatsu Suzuki
    The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
    Hum Immunol 69:781-9. 2008
    ..In essence, disease-specific approaches may be necessary to identify CD8(+) Ts optimally suited to treat immune dysfunctions in different autoimmune syndromes...
  79. ncbi Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice
    B Stoffel
    Institute of Medical Microbiology and Hygiene, University of Cologne, Germany
    Eur J Immunol 28:874-80. 1998
    ..We conclude that ceramide generated by aSMase is not involved in CD28 signal transduction, but rather a perturbation of the secretory system is responsible for the impaired proliferation of aSMase-deficient splenocytes...
  80. pmc CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis
    P Lamprecht
    Department of Rheumatology, University of Luebeck, 23538 Luebeck, Germany
    Thorax 56:751-7. 2001
    ..Lack of CD28 expression on peripheral blood CD4+ and CD8+ T cells has been reported in patients with Wegener's granulomatosis (WG), suggesting a pathogenetic role of CD28- T cells in WG...
  81. ncbi Ras/PI3kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulation
    Urban Sester
    Institute for Immunology, Ruprecht Karls University, Heidelberg, Germany
    Eur J Immunol 37:2881-91. 2007
    ..Likewise, L-plastin is not phosphorylated. Thus, superagonistic CD28 stimulation does not mimic costimulation. Instead, it leads to a Ras/PI3Kinase/cofilin-independent state of "unpolarized T cell activation"...
  82. ncbi Interference with CD28, CD80, CD86 or CD152 in collagen-induced arthritis. Limited role of IFN-gamma in anti-B7-mediated suppression of disease
    A C Tellander
    Active Biotech Research AB, SE-22007 Lund, Sweden
    J Autoimmun 17:39-50. 2001
    ..We also demonstrate that the enhanced production of IFN-gamma observed after B7-blockade is not accountable for the anti-B7 mediated inhibition of CIA...
  83. pmc Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitis
    Christina Duftner
    Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    Arthritis Res Ther 5:R292-300. 2003
    ..MHC class I recognizing and activating natural killer cell receptors on the surface of CD4+CD28- T cells may be involved in a HLA-B27 mediated co-stimulation of these proinflammatory and cytotoxic cells...
  84. ncbi A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28
    Haruo Hanawa
    Department of Microbiology and Immunology, The John P Robarts Research Institute, University of Western Ontario, 1400 Western Road, London, Ontario, Canada N6G 2V4
    Blood 99:2138-45. 2002
    ..These data demonstrate that CD28i, via noncovalent association with CD28, plays a role as a costimulatory signal amplifier in human T cells...
  85. ncbi Therapy with infliximab decreases the CD4+CD28- T cell compartment in peripheral blood in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111, Szczecin, ul Powst Wlkp 72, Poland
    Rheumatol Int 24:351-4. 2004
    ..The results suggest that TNFalpha-neutralizing therapy may restore T cell homeostasis and reduce expansion of the CD28- T cells, which are cytotoxic and may contribute to organ manifestations in RA...
  86. ncbi A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes
    Manisha Deshpande
    National Centre for Cell Science, Ganeshkhind, Pune, India
    Hum Immunol 63:20-3. 2002
    ..In addition, we also report the occurence and sequence of a new CD28 mRNA isoform, one of the above eight, which is a novel variant generated by the use of a new combination of splice donor and acceptor sites...
  87. ncbi CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes
    Joy A Williams
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:2759-65. 2002
    ....
  88. ncbi Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms
    J D zur Hausen
    Roche Research Center, Hoffmann La Roche Inc, Nutley, USA
    Eur J Immunol 27:2643-9. 1997
    ..CD28 co-localizes with Fyn molecules that contain the N terminus and a functional SH2 domain. These results suggest that Fyn association with the TCR-CD3 complex, CD45 and CD28 is mediated by different molecular mechanisms...
  89. pmc Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes
    H Nishina
    Amgen Institute and Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, M5G 2C1 Toronto, Ontario, Canada
    J Exp Med 186:941-53. 1997
    ..Our data provide the first genetic evidence that SEK1 is an important effector molecule that relays CD28 signaling to IL-2 production and T cell proliferation...
  90. ncbi CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response
    W C Gause
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 158:4082-7. 1997
    ..polygyrus-inoculated mice, and elevations in both serum IgG1 and IgE levels occur. These results indicate that the specific kind of type 2 immune response determines whether T cell differentiation to IL-4 production is CD28 dependent...
  91. ncbi CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance
    T L Walunas
    Ben May Institute, University of Chicago, IL 60637, USA
    J Immunol 156:1006-13. 1996
    ..Therefore, it appears that CD28, although not essential for the selection of T cells during development, may allow for additional signals that increase the efficiency of selection and/or expansion of peripheral T cell populations...
  92. pmc CTLA4 mediates antigen-specific apoptosis of human T cells
    J G Gribben
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 92:811-5. 1995
    ..This function appears to be antigen-restricted, since a concomitant signal T-cell receptor signal is required. Regulation of this pathway may provide a novel therapeutic strategy to delete antigen-specific activated T cells...
  93. ncbi Functional disruption of the CD28 gene transcriptional initiator in senescent T cells
    A N Vallejo
    Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 276:2565-70. 2001
    ..Rather, initiators can have a direct role in regulating the expression of specific genes. The gain or loss of initiator activity can be an important determinant of cell phenotypes...
  94. ncbi Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester
    M Tacke
    Institute for Virology and Immunobiology, University of Wurzburg, Germany
    J Immunol 154:5121-7. 1995
    ....
  95. ncbi Timing and casting for actors of thymic negative selection
    N Dautigny
    Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
    J Immunol 162:1294-302. 1999
    ..Finally, we show involvement in opposing directions for p59fyn and SHP-1 molecules in signaling for thymic negative selection...
  96. ncbi Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors
    W Li
    Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, E1540 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, Pennsylvania, 15213, USA
    Transplantation 72:1423-32. 2001
    ....
  97. ncbi Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines
    L P Kane
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Nat Immunol 2:37-44. 2001
    ..Our results provide evidence that CD28 costimulation of different cytokines is mediated by discrete signaling pathways, one of which includes Akt...
  98. ncbi Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28
    W J Metzler
    Nat Struct Biol 4:527-31. 1997
    ..Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site...
  99. ncbi T-cell immunity in acute coronary syndromes
    C M Weyand
    Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:1011-20. 2001
    ..Natural killer T cells have proinflammatory properties and the capability of directly contributing to vascular injury...
  100. ncbi Structure of murine CTLA-4 and its role in modulating T cell responsiveness
    D A Ostrov
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 290:816-9. 2000
    ..This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness...
  101. ncbi Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation
    Y Harada
    Research Institute for Biological Sciences, Science University of Tokyo, 2669 Yamazaki, Noda, Chiba 278-0022, Japan
    J Biol Chem 276:9003-8. 2001
    ..Taken together, these data indicate that PI3K, when associated with the YMNM motif, may act as a negative mediator in CD28-mediated IL-2 gene transcription...

Research Grants74

  1. T Cell Replicative Senescence & Bone Loss During Aging
    Rita Effros; Fiscal Year: 2005
    ....
  2. Mechanisms by which selenium influences T helper cells during immune responses
    Peter R Hoffmann; Fiscal Year: 2010
    ..The goal of this project is to determine the mechanisms by which this potent antioxidant affects the immune system with the intent of providing an important step toward optimal use of Se supplementation. ..
  3. IMMUNE FACTORS IN PEDIATRIC LONG-TERM HIV SURVIVORS
    William Shearer; Fiscal Year: 1999
    ....
  4. CD8 T Cell Interaction with Bone Cells in HIV Disease
    Rita Effros; Fiscal Year: 2005
    ..abstract_text> ..
  5. Conference on the Biology of Aging
    Rita Effros; Fiscal Year: 2007
    ..The dissemination of information that is useful for maintaining the health and vitality of this age group will have a significant impact on the quality of life of a large number of Americans. [unreadable] [unreadable] [unreadable]..
  6. CD8 T Cell Replicative Senescence & HIV Disease
    Rita Effros; Fiscal Year: 2008
    ..This novel approach to analysis of the immune exhaustion in HIV disease may yield promising strategies for immunotherapy to retard or prevent progression to AIDS. ..
  7. CD8 T Cell Replicative Senescence: Impact on Aged Humans
    Rita Effros; Fiscal Year: 2009
    ..abstract_text> ..
  8. Conf on Mechanism and Applications of Immune Tolerance
    Jeffrey Bluestone; Fiscal Year: 2002
    ..Finally, specific talks in immunotherapy of autoimmunity, transplantation, cancer and infectious disease will be included. ..
  9. Expansion of HIV infected T cells for immunotherapy
    James Riley; Fiscal Year: 2005
    ..Successful completion of these aims will pave the way for second generation autologous transfusion trials in which the ability of selected subsets of expanded T cells to fight opportunistic and HIV infection(s) can be measured. ..
  10. Regulation of human T cell activation by the CD28 family
    James Riley; Fiscal Year: 2008
    ..The data generated from these studies will better define the relationship between antigen dependent and independent signals and enable new strategies to modulate T cell activation for therapeutic applications. ..
  11. Development of tumor based antigen presenting cells
    James Riley; Fiscal Year: 2008
    ..Furthermore, these studies will provide the foundation for conducting a clinical trial. ..
  12. Lentiviral Redirected T Cells for B Cancer Immunotherapy
    James Riley; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Role of Notch 1 in Immune Tolerance
    Jeffrey Bluestone; Fiscal Year: 2005
    ..To Identify the biochemical, cellular and genetic effects of Notch signaling in T cells; and Specific Aim #2. In vivo application of Notch signaling for the establishment of peripheral T cell tolerance. ..
  14. Identifying T cell ligands in sarcoidosis
    ANDREW FONTENOT; Fiscal Year: 2005
    ..This novel approach will generate "mimotopes" which can be screened against known peptide/protein sequences and will provide new insight into the etiologic sarcoidosis antigen. ..
  15. PATHOGENIC T CELLS IN BERYLLIUM-INDUCED LUNG DISEASE
    ANDREW FONTENOT; Fiscal Year: 2002
    ..Additional studies will examine whether antigen processing is required for stimulation of these T cell hybridomas. Together, these studies will provide new insight into the immunopathogenesis of CBD and other granulomatous disorders. ..
  16. BLyS, APRIL and antibody production in HIV infection
    Andrea Cerutti; Fiscal Year: 2004
    ..Aim 1. To analyze the mechanisms by which HIV up-regulates BLyS and APRIL in APCs. Aim 2. To analyze the role of BLyS and APRIL in the modulation of HIV-induced antibody production. ..
  17. ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Andrea Cerutti; Fiscal Year: 2003
    ..In addition to elucidating the pathogenesis of RA, the experiments outlined in this application should allow to devise new strategies aimed at reducing the production of pathogenic antibodies, including rheumatoid factors. ..
  18. Pre-Conditioning Pancreatic Islets for Transplantation
    Ginny Bumgardner; Fiscal Year: 2006
    ..The effect of oxygen pre-conditioning on islet viability and function in vivo will be determined using fluorescence microscopy and the marginal mass model of islet transplantation. ..
  19. Immunological control of a persistent viral infection
    Sally R Sarawar; Fiscal Year: 2010
    ..The results obtained may have broader significance in understanding the mechanisms controlling T cell activation or tolerance, in general. ..
  20. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
    ..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
  21. Premature Atherosclerosis in Rheumatic Diseases
    MARY CROW; Fiscal Year: 2006
    ..abstract_text> ..
  22. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  24. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2010
    ....
  25. Negative regulation of TCR-associated PTKs
    ROBERT RICKERT; Fiscal Year: 2007
    ..These issues are important for our understanding of the molecular machinery of T cell activation and the immune response. ..
  26. Role of memory T cell dynamics in SIV infection
    Louis Picker; Fiscal Year: 2007
    ..abstract_text> ..
  27. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  28. HOST DEFENSE TO NEONATAL INRACELLULAR PATHOGENS
    Christopher Wilson; Fiscal Year: 2008
    ..These studies will provide insights into mechanisms for host defense against Lm and for the greater susceptibility of the neonate to this and related intracellular bacterial pathogens. ..
  29. EXPERIMENTAL THERAPY OF CANCER BY COSTIMULATED IMMUNITY
    Lieping Chen; Fiscal Year: 2010
    ..Finally, we will develop and characterize human B7-DC* and PD-1 mAb as a first step towards translation of laboratory study to clinic. Our studies will form the foundation for new approaches towards immunotherapy of cancers. ..
  30. Pathways of T cell Senescence
    ABBE DE VALLEJO; Fiscal Year: 2009
    ....
  31. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2009
    ..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
  32. Gene expression abnormalities in mycosis fungoides
    Henry Wong; Fiscal Year: 2007
    ..3. To study whether the expression of these genes are altered by therapy in vitro and in vivo. [unreadable] [unreadable] [unreadable] [unreadable]..
  33. Interaction between influenza virus and H. influenzae
    Sally Sarawar; Fiscal Year: 2007
    ..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
  34. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  35. A novel substrate of Syk-family PTKs
    ROBERT RICKERT; Fiscal Year: 2007
    ..These experiments will ask how the absence (or severe reduction) of VHR affects TCR-induced activation of MAP kinases, T cell proliferation, effector functions and immune responses in whole animals. ..
  36. BIOCHEMICAL ANALYSIS OF IMMUNOLOGICAL MEMORY
    DONNA FARBER; Fiscal Year: 2007
    ..abstract_text> ..
  37. The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica
    Amnon Altman; Fiscal Year: 2007
    ..abstract_text> ..
  38. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2005
    ....
  39. MACROPHAGE MEDIATED IMMUNOREGULATION VIA TRYPTOPHAN
    David Munn; Fiscal Year: 2002
    ..These studies will define a fundamental and previously unsuspected mechanism of T cell regulation imposed by cells of the innate immune system. ..
  40. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2004
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  41. DNA METHYLATION IN T CELL DEVELOPMENT AND FUNCTION
    Christopher Wilson; Fiscal Year: 2004
    ..2) The increased numbers of TCRgammabeta thymocytes will reflect either increased locus accessibility and rearrangement of the relevant gammabeta TCR genes or reduced Notch signaling. ..
  42. DIETARY FATTY CONTROL OF INFLAMMATION
    Kevin High; Fiscal Year: 2002
    ..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
  43. THYMIC SELECTION AND T CELL LINEAGE COMMITMENT
    Leslie Berg; Fiscal Year: 2003
    ..This information could enhance our understanding of T cell recognition and the establishment of self-tolerance. ..
  44. Novel strategies to prevent islet transplantation rejec*
    Lieping Chen; Fiscal Year: 2003
    ..It is anticipated that these studies will provide a foundation to develop new approaches for islet transplantation and facilitate the treatment of type 1 diabetes mellitus. ..
  45. CD45 REGULATION OF T LYMPHOCYTE ACTIVATION
    David Leitenberg; Fiscal Year: 2003
    ..In addition basic studies on the regulation of T cell activation have broad applicability to fields of cancer pathogenesis, autoimmunity, and infectious disease. ..
  46. PKC theta in the Immune Synapse and T Cell Anergy
    Amnon Altman; Fiscal Year: 2003
    ..They offer the potential for developing novel therapeutic strategies, which may be useful for modulating CD28 costimulation in disease. ..
  47. Immunoregulation in EAE and novel costimulatory pathways
    Samia Khoury; Fiscal Year: 2002
    ..We will also study the in vivo mechanisms of the novel costimulatory pathways by adoptive transfer of STAT4 KO/TCR transgenic or STAT4 KO/TCR transgenic cells into WT or TCRalphabeta KO recipients. ..
  48. IN VIVO FUNCTION OF THE B7 FAMILY OF COSTIMULATORS
    Arlene Sharpe; Fiscal Year: 2004
    ..These studies may thereby assist in the design of optimal therapeutic strategies for manipulation of the B7- CD28/CTLA-4 pathway and also indicate the therapeutic potential of ICOS pathway manipulation. ..
  49. HIV ENV & MACROPHAGE CHEMOKINE RECEPTOR IONIC SIGNALING
    Bruce Freedman; Fiscal Year: 2004
    ....
  50. Protective role of cross-reactive anti-enteric antibody
    Lynn Bry; Fiscal Year: 2005
    ....
  51. CD40L IN ALLOGRAFT TOLERANCE AND VIRAL IMMUNITY
    Richard Pierson; Fiscal Year: 2001
    ..Finally, this study will investigate the potential of CD40L inhibition to induce prolonged acceptance of a transplanted organ, and may contribute to development of clinically relevant approaches to the induction of tolerance. ..
  52. Role of Ikaros in IL-2 gene expression and T cell anergy
    Andrew Wells; Fiscal Year: 2005
    ..Therefore, the studies proposed are consistent with the exploratory nature of the R21 mechanism. ..
  53. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  54. COACTIVATION SIGNALS REGULATE THYMOCYTE DEVELOPMENT
    David McKean; Fiscal Year: 2005
    ..These analyses will determine how signals integrated from different co-inducer receptors stimulate cross-talk between signaling pathways that affects the outcome of thymocyte selection. ..
  55. IONIC CONDUCTANCES AND CD4 LYMPHOCYTE DIFFERENTIATION
    Bruce Freedman; Fiscal Year: 2001
    ..The central hypothesis of this proposal is that the TCR-mediated calcium response regulates CD4plus lymphocyte differentiation, and that Kv channel regulate the secondary responses of differentiated cells to antigen. ..
  56. HEMATOPOIETIC TYROSINE PHOSPHATASE (HEPTP) IN T CELLS
    Tomas Mustelin; Fiscal Year: 2004
    ..This study will thoroughly illuminate the biology of HePTP. The new information will be useful for the design of therapies to treat a variety of hematological diseases such as myelodysplastic syndrome, T cell leukemias and lymphomas. ..
  57. GLOBIN GENE TRANSFER FOR THERAPY OF SICKLE CELL ANEMIA
    Michel Sadelain; Fiscal Year: 2004
    ....
  58. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....
  59. CTLA-4 Inhibition and Autoimmunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2008
    ..abstract_text> ..
  60. Memory CD4 T cell-mediated immunopathology in influenza infection
    DONNA FARBER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. NOVEL THERAPEUTIC TARGETS IN RHEUMATOID ARTHRITIS
    EUGENE ST CLAIR; Fiscal Year: 2003
    ..St.Clair with outstanding clinical research opportunities and educational experiences for his trainees. ..
  62. Dendritic Cell Vaccination During Lymphoid Reconstitution
    Jeffrey Weber; Fiscal Year: 2008
    ..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
  63. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  64. IL-12 as an Adjuvant for a Melanoma Peptide Vaccine
    Jeffrey Weber; Fiscal Year: 2003
    ..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
  65. Abatacept Vs TNF Blockade in Early Rheumatoid Arthritis
    EUGENE ST CLAIR; Fiscal Year: 2007
    ..The proposed clinical trial will compare the remission-inducing capabilities of two novel therapies for early RA, and search for biomarkers that predict treatment response. [unreadable] [unreadable] [unreadable] [unreadable]..
  66. ROLE OF ICOS IN T CELL RESPONSES AND ANTI-TUMOR IMMUNITY
    Gordon Freeman; Fiscal Year: 2004
    ..To examine the expression the expression of ICOS counter-receptor on APC and characterize its molecular structure. SPECIFIC AIM 3. To examine how blocking ICOS signals affect the immune response to murine tumors. ..
  67. THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
    Charles Cook; Fiscal Year: 2007
    ..In general, these studies will explore the immunobiology of murine allograft acceptance, and its relationship to allograft tolerance. ..
  68. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  69. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  70. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  71. HLA-DO in Immunity and Autoimmunity
    Xinjian Chen; Fiscal Year: 2004
    ..abstract_text> ..
  72. Mutations in PKA gene transcripts of lupus T cells
    Dama Laxminarayana; Fiscal Year: 2007
    ..abstract_text> ..
  73. Heterogeneous Subsets of Memory CD4 T cells
    DONNA FARBER; Fiscal Year: 2007
    ..This research proposal will therefore address the basic mechanisms underlying memory T cell heterogeneity, using novel cellular immunologic and molecular approaches. ..