cd18 antigens

Summary

Summary: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.

Top Publications

  1. ncbi Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization
    Eiji Sakurai
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Invest Ophthalmol Vis Sci 44:2743-9. 2003
  2. ncbi Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
    Susumu Ishida
    Angiogenesis Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Med 9:781-8. 2003
  3. pmc A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
    M S Diamond
    Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts
    J Cell Biol 120:545-56. 1993
  4. pmc Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice
    J P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 186:1357-64. 1997
  5. ncbi Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response
    M A Arnaout
    Massachusetts General Hospital, Charlestown 02129
    Immunol Rev 114:145-80. 1990
  6. ncbi Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195 7710, USA
    Blood 98:2403-11. 2001
  7. pmc Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle
    D E Shuster
    U S Department of Agriculture, Agricultural Research Service, Ames, IA
    Proc Natl Acad Sci U S A 89:9225-9. 1992
  8. ncbi Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
    Natalia Beglova
    Department of Pathology, Harvard Medical School, 75 Francis St, Boston, Masschusetts 02115, USA
    Nat Struct Biol 9:282-7. 2002
  9. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
  10. ncbi ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity
    A Kotovuori
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    J Immunol 162:6613-20. 1999

Research Grants

Detail Information

Publications207 found, 100 shown here

  1. ncbi Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization
    Eiji Sakurai
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Invest Ophthalmol Vis Sci 44:2743-9. 2003
    ..To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV)...
  2. ncbi Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
    Susumu Ishida
    Angiogenesis Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Med 9:781-8. 2003
    ..Targeting these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness...
  3. pmc A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
    M S Diamond
    Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts
    J Cell Biol 120:545-56. 1993
    ..Because CBRM1/5 recognizes a fraction of Mac-1 on activated neutrophils, but still blocks Mac-1-dependent adhesion to fibrinogen and ICAM-1, we suggest that only a small subset of Mac-1 molecules is competent to mediate adhesion...
  4. pmc Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice
    J P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 186:1357-64. 1997
    ..Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18-/- mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis...
  5. ncbi Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response
    M A Arnaout
    Massachusetts General Hospital, Charlestown 02129
    Immunol Rev 114:145-80. 1990
    ....
  6. ncbi Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195 7710, USA
    Blood 98:2403-11. 2001
    ....
  7. pmc Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle
    D E Shuster
    U S Department of Agriculture, Agricultural Research Service, Ames, IA
    Proc Natl Acad Sci U S A 89:9225-9. 1992
    ..These results also demonstrate that bovine LAD is genetically homologous and phenotypically similar to human LAD, thus providing a useful animal model for studies of LAD and beta 2 integrin function...
  8. ncbi Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
    Natalia Beglova
    Department of Pathology, Harvard Medical School, 75 Francis St, Boston, Masschusetts 02115, USA
    Nat Struct Biol 9:282-7. 2002
    ....
  9. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
    ..Thus, CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils...
  10. ncbi ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity
    A Kotovuori
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    J Immunol 162:6613-20. 1999
    ..Importantly, soluble ICAM-2Fc was also able to induce T lymphocyte adhesion to purified ICAM-1, -2, and -3, and it was a more potent stimulatory molecule than ICAM-1Fc or ICAM-3Fc...
  11. pmc LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor
    R Schmits
    Amgen Institute, Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
    J Exp Med 183:1415-26. 1996
    ..Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal...
  12. ncbi Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes
    Susanna Fagerholm
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 277:1728-38. 2002
    ..Thus, PKC-mediated phosphorylation of CD18 after cell stimulation could lead to the recruitment of 14-3-3 proteins to the activated integrin, which may play a role in regulating its adhesive state or ability to signal...
  13. pmc A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18
    R Li
    Department of Biochemistry, University of Helsinki, Finland
    J Cell Biol 129:1143-53. 1995
    ..These findings indicate that in addition to induction of CD11a/CD18-mediated cell adhesion, the ICAM-2 peptide may also serve as a "trigger" for high avidity ligand binding of other beta 2 integrins...
  14. ncbi CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    J Immunol 157:3617-26. 1996
    ..Associated protein kinase activity may play a role in signal transduction by CD63 to regulate other cell functions...
  15. pmc Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo
    U Jung
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 102:1526-33. 1998
    ..We conclude that leukocytes integrate chemoattractant signals while rolling along the endothelial surface until they reach a critical level of activation and become firmly adherent...
  16. ncbi Role of p190RhoGAP in beta 2 integrin regulation of RhoA in human neutrophils
    K Dib
    Division of Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    J Immunol 166:6311-22. 2001
    ..Thus, in neutrophils, beta(2) integrin-induced activation of p190RhoGAP requires a signal from a Src family tyrosine kinase, but it does not occur via the signaling pathway responsible for activation of RHOA:..
  17. ncbi Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment
    W M Clark
    Department of Neurology, Oregon Health Sciences University, Portland 97201
    Stroke 22:877-83. 1991
    ..This protective effect supports the active role of leukocytes in central nervous system reperfusion ischemic injury and offers potential for future therapy...
  18. ncbi The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins
    P Bailly
    INSERM U76, Institut National de Transfusion Sanguine, Paris, France
    Eur J Immunol 25:3316-20. 1995
    ..Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycoprotein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology...
  19. pmc Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanism
    M L Entman
    Section of Cardiovascular Sciences, Methodist Hospital, Houston, Texas
    J Clin Invest 85:1497-506. 1990
    ..The results indicate that cytokine stimulation of adult myocytes induces expression of a ligand involved in CD18-dependent adherence of canine neutrophils...
  20. ncbi Differential inside-out activation of beta2-integrins by leukotriene B4 and fMLP in human neutrophils
    Veronika Patcha
    Division of Cell Biology IBK, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Exp Cell Res 300:308-19. 2004
    ..The different modes of the inside-out regulation of beta2-integrins suggest that distinct mechanisms are involved in the beta2-integrin modulation induced by various chemoattractants...
  21. ncbi A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3
    M Van der Vieren
    ICOS Corporation, Bothell, Washington 98021, USA
    Immunity 3:683-90. 1995
    ..The alpha d/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1...
  22. pmc CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen
    J D Loike
    Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 88:1044-8. 1991
    ..Thus, CD11c/CD18 on tumor necrosis factor-stimulated neutrophils functions as a fibrinogen receptor that recognizes the sequence Gly-Pro-Arg in the N-terminal domain of the A alpha chain of fibrinogen...
  23. pmc Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin
    J F Bohnsack
    Department of Pediatrics, University of Utah College of Medicine, Salt Lake City 84132
    J Exp Med 171:1221-37. 1990
    ..These data suggest that human PMNs possess beta 1 and beta 2 classes of integrins, and that both mediate PMN adherence...
  24. ncbi Syk is required for integrin signaling in neutrophils
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Immunity 16:547-58. 2002
    ..Thus, integrins use different signaling mechanisms to support migration and adherent activation...
  25. pmc Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes
    Marek Basler
    Institute of Microbiology CAS, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    Infect Immun 74:2207-14. 2006
    ....
  26. ncbi Immunoreceptor-like signaling by beta 2 and beta 3 integrins
    Zoltan Jakus
    Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary
    Trends Cell Biol 17:493-501. 2007
    ..These and other reports reveal an unexpected similarity between the signal-transduction mechanisms used by integrins and immune recognition receptors...
  27. pmc Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro
    C W Smith
    Speros P Martel Laboratory of Leukocyte Biology, Baylor College of Medicine, Houston, Texas 77054
    J Clin Invest 83:2008-17. 1989
    ..The results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophils to ICAM-1 by a Mac-1-dependent process...
  28. pmc Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin
    T Dileepan
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Infect Immun 75:4851-6. 2007
    ....
  29. ncbi Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
    Eric Sebzda
    Lymphocyte Activation Laboratory, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Immunol 3:251-8. 2002
    ..This shows that, far from playing an inhibitory role during T cell activation, Rap1A positively influences T cells by augmenting lymphocyte responses and directing integrin activation...
  30. ncbi Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18
    L Tian
    Department of Biosciences, University of Helskinki, Finland
    Eur J Immunol 30:810-8. 2000
    ..This binding was blocked by monoclonal antibodies against CD11a/CD18 and ICAM-5. Thus ICAM-5 may act as a major adhesion molecule for leukocyte binding to neurons in the central nervous system...
  31. ncbi Integrin regulation by RhoA in thymocytes
    Susina Vielkind
    Lymphocyte Activation Laboratory, Cancer Research U K London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    J Immunol 175:350-7. 2005
    ..Thus, RhoA has a critical role in regulating cell adhesion and migration during T cell development...
  32. ncbi Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
    Blood 97:1282-8. 2001
    ..Whatever the mechanism, the data provide a novel example of beta1 and beta2 integrin crosstalk in stem/progenitor cell mobilization...
  33. ncbi The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration
    Jurgen Schymeinsky
    Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
    Blood 108:3919-27. 2006
    ..These findings indicate that Syk is critical for beta(2) integrin-mediated neutrophil migration in vitro and plays a fundamental role in neutrophil recruitment during the inflammatory response in vivo...
  34. ncbi Gene targeting yields a CD18-mutant mouse for study of inflammation
    R W Wilson
    Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030
    J Immunol 151:1571-8. 1993
    ..These CD18-mutant mice provide a model of the moderate form of the human disease and should be extremely valuable for in vivo analysis of the role of leukocyte integrin-dependent adhesion in inflammatory disease models...
  35. ncbi Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Curr Opin Cell Biol 9:643-50. 1997
    ..Furthermore, much progress has been made in the study of integrin activation and the role of leukocyte adhesion molecules in disease...
  36. ncbi CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells
    Marissa Marski
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 175:7889-97. 2005
    ..Therefore, we define a crucial role for CD18 in optimal CD4+CD25+ Treg development and function...
  37. ncbi Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
    Jana Kamanova
    Cellular and Molecular Microbiology Division, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
    J Immunol 181:5587-97. 2008
    ....
  38. ncbi RTX toxins recognize a beta2 integrin on the surface of human target cells
    E T Lally
    Leon Levy Research Center for Oral Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6002, USA
    J Biol Chem 272:30463-9. 1997
    ..These experiments identify LFA-1 as a cell surface receptor that mediates toxicity of members of this family of pore-forming toxins...
  39. pmc Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+
    J Richter
    Department of Medicine, University Hospital, Lund, Sweden
    Proc Natl Acad Sci U S A 87:9472-6. 1990
    ..The generation of this Ca2+ signal may explain how adherence, by way of the integrins, changes the functional properties of the cell and enables TNF to induce secretion...
  40. ncbi Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin
    J M van den Berg
    CLB, Sanquin Blood Supply Foundation and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 31:276-84. 2001
    ..As transmigrated neutrophils are surrounded by both beta1 and beta2 ligands in the ECM, this integrin cross-talk could play a role in modifying migration and cellular activation in inflamed tissues...
  41. pmc RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides
    Jana Morova
    Institute of Microbiology of the Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    Proc Natl Acad Sci U S A 105:5355-60. 2008
    ..These results show that binding and killing of target cells by CyaA, LtxA, and HlyA depends on recognition of N-linked oligosaccharide chains of beta(2) integrin receptors. This sets a new paradigm for action of RTX cytotoxins...
  42. pmc Bovine CD18 is necessary and sufficient to mediate Mannheimia (Pasteurella) haemolytica leukotoxin-induced cytolysis
    M S Deshpande
    Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska 68583 0905, USA
    Infect Immun 70:5058-64. 2002
    ..There was a strong correlation between cell surface expression of bovine CD18 and percent cytotoxicity induced by Lkt. These results indicate that bovine CD18 is necessary and sufficient to mediate Lkt-induced cytolysis of target cells...
  43. pmc Spontaneous skin ulceration and defective T cell function in CD18 null mice
    K Scharffetter-Kochanek
    Department of Molecular and Human Genetics, Houston, Texas 77030, USA
    J Exp Med 188:119-31. 1998
    ..The null mice are useful for delineating the functions of CD18 in vivo...
  44. pmc Actinobacillus actinomycetemcomitans leukotoxin requires lipid microdomains for target cell cytotoxicity
    Karen P Fong
    The Leon Levy Research Center for Oral Biology, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
    Cell Microbiol 8:1753-67. 2006
    ..We propose that toxin-induced Ca2+ fluxes mobilize LFA-1 to lipid rafts where it associates with Ltx. These findings suggest that Ltx utilizes the raft to stimulate an integrin signalling pathway that leads to apoptosis of target cells...
  45. ncbi Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils
    Chad E Green
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Immunol 172:7780-90. 2004
    ..Taken together, the data suggest that E-selectin is unique among selectins in its capacity for clustering sialylated ligands and transducing signals leading to neutrophil arrest in shear flow...
  46. ncbi Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2)
    R Mathison
    Department of Physiology and Biophysics, Faculty of Medicine, The University of Calgary, AB, Canada
    Can J Physiol Pharmacol 79:785-92. 2001
    ..The inhibition by these tripeptides on neutrophil adhesion to myocytes suggests that salivary glands hormones regulate the severity of cardiac inflammation...
  47. pmc The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)
    P Guermonprez
    Unit of Biology of Immune Regulations, Institut Pasteur, Paris, France
    J Exp Med 193:1035-44. 2001
    ..Thus, the cellular distribution of CD11b, mostly on neutrophils, macrophages, and dendritic and natural killer cells, supports a role for CyaA in disrupting the early, innate antibacterial immune response...
  48. ncbi Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migration
    Je Won Ryu
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Arterioscler Thromb Vasc Biol 24:864-70. 2004
    ..Here we investigated whether UCP2 regulates expression of genes involved in monocyte recruitment...
  49. ncbi Locomotion of monocytes on endothelium is a critical step during extravasation
    Alan R Schenkel
    Department of Pathology, Weill Medical College of Cornell University, Room C320, 1300 York Avenue, New York, New York 10021, USA
    Nat Immunol 5:393-400. 2004
    ..The blocked monocytes spun in circles as if they were unable to direct their movement despite being able to adhere and polarize normally. This step fills a gap in the paradigm of extravasation as a multistep process...
  50. pmc Mannheimia (Pasteurella) haemolytica leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18
    R S Gopinath
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0905, USA
    Infect Immun 73:6179-82. 2005
    ..Leukotoxin specifically lysed transfectants expressing bovine CD18 fragment encompassing amino acids 1 to 291, indicating that leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18...
  51. ncbi Recombinant expression of bovine LFA-1 and characterization of its role as a receptor for Mannheimia haemolytica leukotoxin
    Thamotharampillai Dileepan
    Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA
    Microb Pathog 38:249-57. 2005
    ..This is the first report on recombinant expression of functionally active bovine LFA-1 by transduction into an LktA-non-susceptible human cell line...
  52. ncbi Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands
    Michaeline Bunting
    Program in Human Molecular Biology and Genetics, Huntsman Cancer Institute, Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, USA
    Curr Opin Hematol 9:30-5. 2002
    ....
  53. pmc CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes
    Shayne C Barlow
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Am J Pathol 165:1849-52. 2004
    ..This study demonstrates that the beta(2) integrins play a key pathophysiological role in the development of multiple low-dose streptozotocin-induced autoimmune diabetes...
  54. ncbi Increased CD11/CD18 expression and altered metabolic activity on polymorphonuclear leukocytes from patients with polycythemia vera and essential thrombocythemia
    Carmen Burgaleta
    Services of Hematology, Principe de Asturias, Department of Medicine, University of Alcala de Henares, Madrid, Spain
    Acta Haematol 108:23-8. 2002
    ..001). These data confirm the presence of a complex neutrophil dysfunction in PV and ET that probably reflects intrinsic abnormalities induced by changes in the cells' surface of the neoplastic clone and impaired signal transduction...
  55. ncbi Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration
    Guy Cinamon
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 173:7282-91. 2004
    ....
  56. ncbi CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycans
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 169:5270-8. 2002
    ..These findings implicate epithelial cell surface proteoglycans decorated with sulfated fucose moieties as ligands for CD11b/CD18 during PMN migration across mucosal surfaces...
  57. pmc beta1 and beta2 integrins activate different signalling pathways in monocytes
    Merit Reyes-Reyes
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas UNAM, Apto Postal 70228, Cd Universitaria, Mexico D F 04510, Mexico
    Biochem J 363:273-80. 2002
    ..These data suggest that distinct integrins activate different signalling pathways in monocytic cells...
  58. ncbi Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium
    Robert A Bowden
    Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Circ Res 90:562-9. 2002
    ..We conclude tissue-specific differences in endothelial cells account, at least partially, for CD18-independent neutrophil infiltration in the heart...
  59. ncbi LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo
    Sravanthi Kandula
    Department of Medicine, Section of Gastroenterology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 173:4443-51. 2004
    ..Taken together, these results demonstrate that LFA-1 is required for optimal CD4(+) T cell priming in vivo...
  60. pmc Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease
    Christopher G Kevil
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Am J Pathol 165:609-16. 2004
    ..These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE...
  61. ncbi Manifestations of inflammatory arthritis are critically dependent on LFA-1
    Gerald M Watts
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:3668-75. 2005
    ..Blocking mAbs further revealed an ongoing requirement for LFA-1 I-domain adhesive function in disease perpetuation. These findings suggest that the LFA-1 I-domain forms an attractive target for treatment of human inflammatory arthritis...
  62. ncbi The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization
    Thalia Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195, USA
    Blood 101:4739-47. 2003
    ..Collectively, our data unveil a novel example of mobilization through pharmacologic modulation of signaling...
  63. ncbi Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes
    Huaizhu Wu
    Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    J Immunol 173:297-306. 2004
    ....
  64. pmc Neutrophil string formation: hydrodynamic thresholding and cellular deformation during cell collisions
    K E Kadash
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 86:4030-9. 2004
    ....
  65. ncbi Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration
    Yuan Liu
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:10028-36. 2002
    ..Taken together, these results demonstrate that PMN migration is regulated by CD47 through SIRPalpha-dependent and SIRPalpha-independent mechanisms...
  66. pmc Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions
    C A Lowell
    Department of Laboratory Medicine, University of California, San Francisco 94143, USA
    J Cell Biol 133:895-910. 1996
    ....
  67. ncbi E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils
    Sarah R McMeekin
    Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Blood 107:4938-45. 2006
    ....
  68. pmc Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains
    K S Weber
    Institut für Prophylaxe der Kreislaufkrankheiten, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    Mol Biol Cell 10:861-73. 1999
    ..Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains...
  69. pmc Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation
    T B Issekutz
    Department of Medicine, University of Toronto, Ontario, Canada
    J Exp Med 183:2175-84. 1996
    ..However, there exists an additional CD18- and VLA-4-independent pathway of neutrophil migration to arthritic joints that is not involved in acute dermal inflammation...
  70. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
    ..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
  71. ncbi A role for beta(2) integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response
    B Walzog
    Department of Physiology, Freie Universitat, D 14195 Berlin, Germany
    FASEB J 13:1855-65. 1999
    ..Altogether, the present findings provide evidence for a functional link between clotting and inflammatory responses that may contribute to the recruitment and/or activation of PMN and other cells at sites of lesion...
  72. ncbi Mannheimia haemolytica leukotoxin-induced cytolysis of caprine (Capra hircus) leukocytes is mediated by the CD18 subunit of beta2-integrins
    T Fett
    Department of Pathology, Faculty of Veterinary Medicine, University of Liege, FMV Sart Tilman B43, B 4000 Liege, Belgium
    Microb Pathog 45:337-42. 2008
    ..Taken together, these results indicate that CD18 on caprine leukocytes serves as a receptor for Lkt...
  73. ncbi CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits
    C M Doerschuk
    University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
    J Immunol 144:2327-33. 1990
    ..However, PMN adherence in the pulmonary circulation may occur by either CD18-dependent or -independent mechanisms that are specific to the inciting stimulus...
  74. ncbi Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility
    Thamotharampillai Dileepan
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    FEMS Microbiol Lett 274:67-72. 2007
    ..The results demonstrate unequivocally that the I-EGF-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to M. haemolytica leukotoxin...
  75. ncbi Bordetella adenylate cyclase toxin: a swift saboteur of host defense
    Jana Vojtova
    Institute of Microbiology of the Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic
    Curr Opin Microbiol 9:69-75. 2006
    ..Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen...
  76. ncbi PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by beta(2)-integrin ligation
    L T Duong
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Cell Motil Cytoskeleton 47:174-88. 2000
    ..We propose that Pyk2 is functionally linked to the formation of podosomes where it mediates the integrin-cytoskeleton interface and regulates cell spreading and migration...
  77. ncbi Regulation of integrin function by the urokinase receptor
    Y Wei
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 273:1551-5. 1996
    ..These data provide a paradigm for regulation of integrins in which a nonintegrin membrane receptor interacts with and modifies the function of activated integrins...
  78. pmc Vav GEFs are required for beta2 integrin-dependent functions of neutrophils
    M Angelica Martinez Gakidis
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 166:273-82. 2004
    ..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis...
  79. ncbi Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway
    S I Simon
    Speros Martel Section of Leukocyte Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 164:4348-58. 2000
    ..We conclude that neutrophils rolling on E-selectin undergo signal transduction leading to activation of cell arrest through beta 2 integrins binding to ICAM-1...
  80. pmc A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice
    D C Bullard
    Department of Molecular, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 93:2116-21. 1996
    ..This phenotype provides a model for inflammatory skin disorders, may have general relevance to polygenic human inflammatory diseases, and should help to identify genes that interact with the beta2 integrins in inflammatory processes...
  81. ncbi Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment
    J W Huleatt
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington 06030, USA
    Immunity 5:263-73. 1996
    ..These results demonstrated that ICAM-1 and beta2 integrins were required for establishment of a normal intestinal immune system...
  82. ncbi Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr
    C M Vines
    Department of Pathology and Cancer Research Facility, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Immunity 15:507-19. 2001
    ..The inhibitory effects of Fgr are independent of its kinase activity, are dose dependent, and can be overcome by chemokines and inflammatory mediators...
  83. pmc CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits
    R K Winn
    Department of Surgery, University of Washington School of Medicine, Seattle 98104
    J Clin Invest 92:1168-73. 1993
    ..These studies demonstrate that: (a) early (4 h) PMN emigration is CD11/CD18 dependent; (b) late (24 h) PMN emigration is CD11/CD18 independent; and (c) mononuclear cells utilize the integrins CD18 and CD49d...
  84. ncbi Migration of human polymorphonuclear leukocytes through a synovial fibroblast barrier is mediated by both beta 2 (CD11/CD18) integrins and the beta 1 (CD29) integrins VLA-5 and VLA-6
    J X Gao
    Department of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Immunol 163:178-86. 1995
    ....
  85. pmc Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav
    L Zheng
    Department of Cell Biology, , Sweden
    Proc Natl Acad Sci U S A 93:8431-6. 1996
    ..Taken together, these results indicate that antibody-induced engagement of beta 2 integrins on neutrophils triggers tyrosine phosphorylation of Vav and, possibly through its association, a downstream activation of p21ras...
  86. ncbi Effects of intestinal lymph on expression of neutrophil adhesion factors and lung injury after trauma-induced shock
    Zuo Bing Chen
    Department of Emergency Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China
    World J Gastroenterol 10:3221-4. 2004
    ..To study how intestinal lymph after trauma-induced shock (TIS) interferes with expression of neutrophil adhesion factors (CD11b and CD18) and causes lung injury...
  87. ncbi Promotion of leukocyte adhesion by a novel interaction between vitronectin and the beta2 integrin Mac-1 (alphaMbeta2, CD11b/CD18)
    Sandip M Kanse
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Arterioscler Thromb Vasc Biol 24:2251-6. 2004
    ..Until now, only an indirect interaction between Mac-1 and VN via the urokinase receptor (urokinase plasminogen activator receptor) was known. We now propose that Mac-1 and VN can directly interact with each other...
  88. ncbi Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:44924-30. 2004
    ..Given the known sorting properties of BAP31, these findings suggest that BAP31 may play a role in regulating intracellular trafficking of CD11b/CD18 in neutrophils...
  89. ncbi Leukocyte-epithelial interactions
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Boulevard, Room 1053, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Cell Biol 15:557-64. 2003
    ....
  90. ncbi Proinflammatory effects of copper deficiency on neutrophils and lung endothelial cells
    David Lominadze
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Immunol Cell Biol 82:231-8. 2004
    ..Combined, these results support the theory that dietary copper deficiency has proinflammatory effects on both neutrophils and the microvascular endothelium that promote neutrophil-endothelial interactions...
  91. ncbi Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils
    Tarek Khreiss
    Research Center, Maisonneuve Rosemont Hospital, and Department of Medicine, University of Montreal, 5415 Boulevard de l Assomption, Montreal, Quebec, Canada
    Cell Signal 16:801-10. 2004
    ..These results indicate that PAF-induced activation of ERK contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis, thereby amplifying the inflammatory response...
  92. ncbi Engagement of PSGL-1 enhances beta(2)-integrin-involved adhesion of neutrophils to recombinant ICAM-1
    Xiao guang Wang
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Acta Pharmacol Sin 27:617-22. 2006
    ..Our present work aimed to investigate the mechanism by which PSGL-1-mediated signal activates neutrophils and enhances the adhesion to the endothelial cells...
  93. ncbi Expression of activation molecules in neutrophils, monocytes and lymphocytes from patients with unstable angina treated with stent implantation
    Victor Sanchez-Margalet
    Department of Clinical Biochemistry, Virgen Macarena University Hospital, Seville, Spain
    Clin Chem Lab Med 42:273-8. 2004
    ....
  94. ncbi Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion
    Ulrich J H Sachs
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    Blood 104:727-34. 2004
    ..In conclusion, some anti-Mart alloantibodies interfere with Mac-1-dependent cellular functions of neutrophils, cause NAIN, and may be used as tools for studying Mac-1-dependent functions...
  95. ncbi Polymorphonuclear leukocyte integrin profile in vascular atherosclerotic disease
    Rosalia Lo Presti
    Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universita di Palermo, Palermo, Italy
    Clin Hemorheol Microcirc 30:53-60. 2004
    ....
  96. ncbi Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on LPS-induced mesenteric microcirculatory disturbance in rats
    Jun Guo
    Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China
    Shock 29:205-11. 2008
    ..Treatment with DLA or SAB significantly ameliorated LPS-induced microcirculatory disturbance in rat mesentery and inhibited both the expression of CD11b and CD18 and the production of *O2- and H2O2 by neutrophils caused by LPS...
  97. ncbi Ovarian cancer cells modulate human blood neutrophils response to activation in vitro
    M Klink
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Scand J Immunol 68:328-36. 2008
    ..Our results suggest the possibility that neutrophils responding to contact with cancer cells contribute to the progression and metastatic potential of tumour cells...
  98. ncbi Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2
    Dmitry A Solovjov
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:1336-45. 2005
    ..These data indicate that each subunit of alphaMbeta2 contributes distinct properties to alphaMbeta2 and that, in most but not all cases, the response of the integrin is a composite of the functions of its individual subunits...
  99. ncbi Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in diabetic mice with sepsis
    Wan Chun Chiu
    Graduate Institute of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan, ROC
    Br J Nutr 97:685-91. 2007
    ..The present findings suggest that compared with the diabetic mice fed SO, a low-dose n-3 fatty acid supplementation may attenuate leucocyte adhesion and infiltration into tissues in diabetic mice complicated with sepsis...
  100. ncbi Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18
    Dale J Powner
    CRUK Institute for Cancer Studies, The Medical School, The University of Birmingham, Birmingham, B15 2TT, UK
    Mol Immunol 44:3211-21. 2007
    ..Thus, these data indicate that PLD-synthesised PtdOH stimulates the generation of PtdIns(4,5)P(2), which in turn mediates talin binding to, and activation of, CD11b/CD18 required for neutrophil stable adhesion and migration...
  101. pmc Src family kinases mediate neutrophil adhesion to adherent platelets
    Virgilio Evangelista
    Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
    Blood 109:2461-9. 2007
    ..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...

Research Grants62

  1. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..These studies will provide new insight on the mechanisms regulating sickle cell VOC and lead to novel ways to target inflammation. ..
  2. Very Late Antigen Integrin Activity on T Cells
    Yoji Shimizu; Fiscal Year: 2010
    ....
  3. Beta2 Integrin Activation and Signaling
    Vineet Gupta; Fiscal Year: 2010
    ..The insights gained from these studies are also likely to extend to other integrins. ..
  4. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2011
    ....
  5. Molecular Basis of Mo1 LFA 1 Deficiency
    M Amin Arnaout; Fiscal Year: 2013
    ..Biochemical, immunochemical, genetic and structural approaches and animal models will be utilized by a multidisciplinary group of investigators to achieve these goals. ..
  6. Multiscale modeling of leukocyte-tumor cell adhesion to endothelium in shear flow
    Cheng Dong; Fiscal Year: 2010
    ....
  7. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 2000
    ..These studies should yield new insights into the basic mechanisms of neutrophil-endothelial interactions in reperfusion injury and potentially suggest new therapeutic strategies to a wide range of important disease processes. ..
  8. Hemostatic Factors and Tumor Biology
    Joseph Palumbo; Fiscal Year: 2007
    ..The planned program will provide the record of productivity, knowledge and skills necessary to establish a successful career as an independent physician/scientist. ..
  9. Selectin Control of Leukocyte Adhesion in Shear
    Michael Lawrence; Fiscal Year: 2006
    ..Such insight may lead to identification of more effective molecular targets for anti-inflammatory therapeutics. ..
  10. T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITIS
    Jeffrey Curtis; Fiscal Year: 2002
    ..Our long-term goal is to develop effective therapies to treat established SLE based on anti-adhesive strategies. ..
  11. INTEGRIN ASSOCIATED PROTEIN IS A THROMBOSPONDIN RECEPTOR
    William Frazier; Fiscal Year: 2000
    ..This work can potentially yield information and compounds of therapeutic value in hemostasis and thrombosis, wound healing, angiogenesis and inflammatory diseases such as arthritis. ..
  12. INTEGRINS AND PMN MOTILITY
    WILLIAM HENDEY; Fiscal Year: 2000
    ..Finally, relationship between beta2 phosphorylation and beta3-mediated attachment or detachment will be assessed. ..
  13. BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILS
    Mimi Takami; Fiscal Year: 2003
    ..And, as a biological model, we will explore the way in which exposure to Helicobacter pylori, may impact these signals and affect neutrophil adhesion and migration on epithelial surfaces. ..
  14. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  15. HTS Assay for Discovery:Small Molecule Regulators (RMI)
    Vineet Gupta; Fiscal Year: 2005
    ..Given the central role of beta2 integrins in regulating leukocyte function, we hope that this research will provide important new tools and further guide future experimentation. ..
  16. ISOLATED PSGL-1 AND MAC-1 ADHESION TO ENDOTHELIUM
    DOUGLAS GOETZ; Fiscal Year: 2003
    ..abstract_text> ..
  17. CD11B/CD18 AND NEUTROPHIL EPITHELIAL INTERACTIONS
    CHARLES PARKOS; Fiscal Year: 2003
    ..abstract_text> ..
  18. BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILS
    Mimi Takami; Fiscal Year: 2003
    ..We will examine the relationship of these events to the complex shape changes involved in aggrevated and transmigration. ..
  19. GENETIC MOUSE MODELS FOR CHRONIC INFLAMMATORY DISEASE
    Daniel Bullard; Fiscal Year: 2006
    ..abstract_text> ..
  20. CONDITIONAL B INTEGRIN BLOCKADE, PMN TRAFFICKING
    ASRAR MALIK; Fiscal Year: 2004
    ..abstract_text> ..
  21. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  22. THE PROTEIN C RECEPTOR AND WEGENER'S VASCULOPATHY
    Shinichiro Kurosawa; Fiscal Year: 2003
    ..In addition, the results will provide a foundation for future studies investigating potential therapeutic targets that modulate neutrophil-mediated endothelial injury, particularly for cANCA-mediated vasculitis. ..
  23. CONTACT DEPENDENT ENDOTHELIAL ACTIVATION BY NK CELLS
    Jeffrey Bender; Fiscal Year: 2003
    ..This work may provide direction for pharmacologic and/or genetic manipulations, thereby interfering with endothelial activation and immune-mediated vasculopathy in clinical transplants. ..
  24. PMN MOTILITY AND ADHERENCE IN NEONATES
    C Smith; Fiscal Year: 1999
    ..This involves assessment of acute inflammation in response to nonspecific stimuli, evaluation of the adhesion cascade using intravital microscopy, and responses to specific bacteria (e.g., group B Streptococcus). ..
  25. THE REGULATION OF BETA-2 INTEGRIN FUNCTION
    LLOYD KLICKSTEIN; Fiscal Year: 2004
    ..A further understanding of how lymphocytes regulate adhesion will lead to new strategies for the development of anti-inflammatory therapies with potential applications in autoimmune disease and transplantation medicine. ..
  26. PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATION
    William Muller; Fiscal Year: 2003
    ..We have generated mice that are genetically deficient in PECAM and mice in which PECAM does not function. These mice will be critical to evaluate PECAM-independent TEM. ..
  27. PMN integrins, apoptosis and inflammation
    WILLIAM HENDEY; Fiscal Year: 2007
    ..An understanding of this pathway would provide novel targets for the control of inflammation. ..
  28. GENES ENCODING T CELL RECEPTORS
    Ellis Reinherz; Fiscal Year: 2006
    ..Third, the molecular mechanism by which the CD2 cytoplasmic tail interacting proteins CD2BP1, CD2BP3 and CD2BP4 affect cell motility, polarity and lipid biogenesis will be investigated. ..
  29. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2009
    ..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
  30. Resolution of Gouty Inflammation
    STEPHEN MALAWISTA; Fiscal Year: 2008
    ..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
  31. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  32. LYME DISEASE--HOST PARASITE INTERACTIONS
    STEPHEN MALAWISTA; Fiscal Year: 2003
    ..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
  33. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  34. NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASE
    Jessica Moreland; Fiscal Year: 2004
    ....
  35. Mechanisms of Eosinophil Adhesion
    Xiangdong Zhu; Fiscal Year: 2006
    ..Knowledge of the signaling components required for eosinophil adhesion may provide insight into the pathogenesis of airway inflammation and lead to therapeutic interventions for human asthma. ..
  36. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2009
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  37. Development of Novel Regimens for the Prevention of Chronic Renal Failure
    CARL SHELLEY; Fiscal Year: 2008
    ..In this way we expect to provide proof-of-principal for new therapeutic regimens that reduce the ability of hypoxia to cause CRF. ..
  38. UCSD Hillcrest Flow Cytometer
    Paul Mills; Fiscal Year: 2003
    ..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
  39. DIFFUSION MRI AS BIOMARKER FOR THERAPY RESPONSE IN BREAST CANCER METASTASES
    Alison T Stopeck; Fiscal Year: 2010
    ....
  40. Lipid Raft Microdomains in Neutrophil Function
    ROBERT GARY SITRIN; Fiscal Year: 2010
    ..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
  41. Interferon Regulation in Systemic Lupus
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..These experiments will yield insight into the molecular pathogenesis of SLE and identify novel therapeutic approaches to manipulatecytokine activity in SLE at the level of signal transduction. ..
  42. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
    ..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
  43. Dynamic Strenghts of Leukoctye Adhesion Bonds
    Evan A Evans; Fiscal Year: 2011
    ..abstract_text> ..
  44. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul J Mills; Fiscal Year: 2010
    ..abstract_text> ..
  45. Acute renal failure after whole body ischemia
    Hamid Rabb; Fiscal Year: 2008
    ..Our long-term goals are to develop a clinically relevant experimental model which can be used to develop novel therapies for ARF. [unreadable] [unreadable] [unreadable]..
  46. RR-03-011, Extramural Research Facilities Construction *
    Dallas Hyde; Fiscal Year: 2004
    ..Construction of the proposed facility will permit consolidation of existing research activities with human pathogens in modern BSL-2 and BSL-3 containment. ..
  47. Anthrax Vaccine Formulations Combining PA/Spore Epitopes
    AAIYAPPA PALECANDA; Fiscal Year: 2005
    ..Significance: This research is relevant to the potential to develop novel vaccine formulations and therapeutics to counter inhalation anthrax. ..
  48. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2004
    ..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
  49. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2005
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
  50. Adjuvant immunotherapy for non-small cell lung cancer
    Michael Roth; Fiscal Year: 2005
    ..abstract_text> ..
  51. REGULATION OF MICROVASCULAR PERMEABILITY BY NITRIC OXIDE
    ROLANDO RUMBAUT; Fiscal Year: 2004
    ..The long-term goal is to apply the knowledge gained from these studies to allow optimal management of patients with these important clinical entities and their associated microvascular alterations. ..
  52. Biomechanics on Neutrophil Rolling on the Endothelium
    Jin Yu Shao; Fiscal Year: 2006
    ..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
  53. The Urokinase-CD87 System in Macrophage Activation
    Robert Sitrin; Fiscal Year: 2004
    ....
  54. EXTRAVASCULAR TRAFFICKING OF HIV+ CELLS AND PROGNOSIS
    Holly Birdsall; Fiscal Year: 2003
    ....
  55. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  56. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. MECHANISMS OF NOVEL ANTI-INFLAMMATORY ACTIONS OF SLPI
    Aihao Ding; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. MRFASS--MINORITIES, RISK FACTOR AND STROKE STUDY
    Stanley Tuhrim; Fiscal Year: 2003
    ..Stroke-free survival rates will be estimated for each ethnic group and the independent determinants of recurrence will be identified with multivariate statistical techniques. ..
  59. Vector-based Generation of Monoclonal Antibodies against the CB2 Receptor
    Michael Roth; Fiscal Year: 2007
    ..This work has the capacity to significantly accelerate cannabinoid research. [unreadable] [unreadable] [unreadable]..
  60. Immunoreceptors
    Michael Dustin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..