Genomes and Genes
Summary: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
Publications207 found, 100 shown here
- Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularizationEiji Sakurai
Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
Invest Ophthalmol Vis Sci 44:2743-9. 2003..To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV)...
- Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in diseaseSusumu Ishida
Angiogenesis Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, Massachusetts 02114, USA
Nat Med 9:781-8. 2003..Targeting these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness...
- A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogenM S Diamond
Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts
J Cell Biol 120:545-56. 1993..Because CBRM1/5 recognizes a fraction of Mac-1 on activated neutrophils, but still blocks Mac-1-dependent adhesion to fibrinogen and ICAM-1, we suggest that only a small subset of Mac-1 molecules is competent to mediate adhesion...
- Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient miceJ P Mizgerd
Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Exp Med 186:1357-64. 1997..Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18-/- mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis...
- Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory responseM A Arnaout
Massachusetts General Hospital, Charlestown 02129
Immunol Rev 114:145-80. 1990....
- Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectinsT Papayannopoulou
Division of Hematology, University of Washington, Seattle 98195 7710, USA
Blood 98:2403-11. 2001....
- Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattleD E Shuster
U S Department of Agriculture, Agricultural Research Service, Ames, IA
Proc Natl Acad Sci U S A 89:9225-9. 1992..These results also demonstrate that bovine LAD is genetically homologous and phenotypically similar to human LAD, thus providing a useful animal model for studies of LAD and beta 2 integrin function...
- Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activationNatalia Beglova
Department of Pathology, Harvard Medical School, 75 Francis St, Boston, Masschusetts 02115, USA
Nat Struct Biol 9:282-7. 2002....
- A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammationA Coxon
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Immunity 5:653-66. 1996..Thus, CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils...
- ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinityA Kotovuori
Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
J Immunol 162:6613-20. 1999..Importantly, soluble ICAM-2Fc was also able to induce T lymphocyte adhesion to purified ICAM-1, -2, and -3, and it was a more potent stimulatory molecule than ICAM-1Fc or ICAM-3Fc...
- LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumorR Schmits
Amgen Institute, Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
J Exp Med 183:1415-26. 1996..Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal...
- Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytesSusanna Fagerholm
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
J Biol Chem 277:1728-38. 2002..Thus, PKC-mediated phosphorylation of CD18 after cell stimulation could lead to the recruitment of 14-3-3 proteins to the activated integrin, which may play a role in regulating its adhesive state or ability to signal...
- A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18R Li
Department of Biochemistry, University of Helsinki, Finland
J Cell Biol 129:1143-53. 1995..These findings indicate that in addition to induction of CD11a/CD18-mediated cell adhesion, the ICAM-2 peptide may also serve as a "trigger" for high avidity ligand binding of other beta 2 integrins...
- CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophilsK M Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
J Immunol 157:3617-26. 1996..Associated protein kinase activity may play a role in signal transduction by CD63 to regulate other cell functions...
- Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivoU Jung
Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
J Clin Invest 102:1526-33. 1998..We conclude that leukocytes integrate chemoattractant signals while rolling along the endothelial surface until they reach a critical level of activation and become firmly adherent...
- Role of p190RhoGAP in beta 2 integrin regulation of RhoA in human neutrophilsK Dib
Division of Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
J Immunol 166:6311-22. 2001..Thus, in neutrophils, beta(2) integrin-induced activation of p190RhoGAP requires a signal from a Src family tyrosine kinase, but it does not occur via the signaling pathway responsible for activation of RHOA:..
- Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatmentW M Clark
Department of Neurology, Oregon Health Sciences University, Portland 97201
Stroke 22:877-83. 1991..This protective effect supports the active role of leukocytes in central nervous system reperfusion ischemic injury and offers potential for future therapy...
- The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrinsP Bailly
INSERM U76, Institut National de Transfusion Sanguine, Paris, France
Eur J Immunol 25:3316-20. 1995..Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycoprotein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology...
- Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanismM L Entman
Section of Cardiovascular Sciences, Methodist Hospital, Houston, Texas
J Clin Invest 85:1497-506. 1990..The results indicate that cytokine stimulation of adult myocytes induces expression of a ligand involved in CD18-dependent adherence of canine neutrophils...
- Differential inside-out activation of beta2-integrins by leukotriene B4 and fMLP in human neutrophilsVeronika Patcha
Division of Cell Biology IBK, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
Exp Cell Res 300:308-19. 2004..The different modes of the inside-out regulation of beta2-integrins suggest that distinct mechanisms are involved in the beta2-integrin modulation induced by various chemoattractants...
- A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3M Van der Vieren
ICOS Corporation, Bothell, Washington 98021, USA
Immunity 3:683-90. 1995..The alpha d/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1...
- CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogenJ D Loike
Columbia University, New York, NY 10032
Proc Natl Acad Sci U S A 88:1044-8. 1991..Thus, CD11c/CD18 on tumor necrosis factor-stimulated neutrophils functions as a fibrinogen receptor that recognizes the sequence Gly-Pro-Arg in the N-terminal domain of the A alpha chain of fibrinogen...
- Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for lamininJ F Bohnsack
Department of Pediatrics, University of Utah College of Medicine, Salt Lake City 84132
J Exp Med 171:1221-37. 1990..These data suggest that human PMNs possess beta 1 and beta 2 classes of integrins, and that both mediate PMN adherence...
- Syk is required for integrin signaling in neutrophilsAttila Mocsai
Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
Immunity 16:547-58. 2002..Thus, integrins use different signaling mechanisms to support migration and adherent activation...
- Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytesMarek Basler
Institute of Microbiology CAS, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
Infect Immun 74:2207-14. 2006....
- Immunoreceptor-like signaling by beta 2 and beta 3 integrinsZoltan Jakus
Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary
Trends Cell Biol 17:493-501. 2007..These and other reports reveal an unexpected similarity between the signal-transduction mechanisms used by integrins and immune recognition receptors...
- Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitroC W Smith
Speros P Martel Laboratory of Leukocyte Biology, Baylor College of Medicine, Houston, Texas 77054
J Clin Invest 83:2008-17. 1989..The results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophils to ICAM-1 by a Mac-1-dependent process...
- Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxinT Dileepan
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
Infect Immun 75:4851-6. 2007....
- Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signalingEric Sebzda
Lymphocyte Activation Laboratory, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Immunol 3:251-8. 2002..This shows that, far from playing an inhibitory role during T cell activation, Rap1A positively influences T cells by augmenting lymphocyte responses and directing integrin activation...
- Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18L Tian
Department of Biosciences, University of Helskinki, Finland
Eur J Immunol 30:810-8. 2000..This binding was blocked by monoclonal antibodies against CD11a/CD18 and ICAM-5. Thus ICAM-5 may act as a major adhesion molecule for leukocyte binding to neurons in the central nervous system...
- Integrin regulation by RhoA in thymocytesSusina Vielkind
Lymphocyte Activation Laboratory, Cancer Research U K London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
J Immunol 175:350-7. 2005..Thus, RhoA has a critical role in regulating cell adhesion and migration during T cell development...
- Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient miceT Papayannopoulou
Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
Blood 97:1282-8. 2001..Whatever the mechanism, the data provide a novel example of beta1 and beta2 integrin crosstalk in stem/progenitor cell mobilization...
- The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migrationJurgen Schymeinsky
Department of Physiology, Ludwig Maximilians Universitat Munchen, Schillerstr 44, D 80336 MUnchen, Germany
Blood 108:3919-27. 2006..These findings indicate that Syk is critical for beta(2) integrin-mediated neutrophil migration in vitro and plays a fundamental role in neutrophil recruitment during the inflammatory response in vivo...
- Gene targeting yields a CD18-mutant mouse for study of inflammationR W Wilson
Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030
J Immunol 151:1571-8. 1993..These CD18-mutant mice provide a model of the moderate form of the human disease and should be extremely valuable for in vivo analysis of the role of leukocyte integrin-dependent adhesion in inflammatory disease models...
- Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion moleculesC G Gahmberg
Department of Biosciences, University of Helsinki, Finland
Curr Opin Cell Biol 9:643-50. 1997..Furthermore, much progress has been made in the study of integrin activation and the role of leukocyte adhesion molecules in disease...
- CD18 is required for optimal development and function of CD4+CD25+ T regulatory cellsMarissa Marski
Department of Medicine, University of Chicago, IL 60637, USA
J Immunol 175:7889-97. 2005..Therefore, we define a crucial role for CD18 in optimal CD4+CD25+ Treg development and function...
- Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive rufflingJana Kamanova
Cellular and Molecular Microbiology Division, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
J Immunol 181:5587-97. 2008....
- RTX toxins recognize a beta2 integrin on the surface of human target cellsE T Lally
Leon Levy Research Center for Oral Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6002, USA
J Biol Chem 272:30463-9. 1997..These experiments identify LFA-1 as a cell surface receptor that mediates toxicity of members of this family of pore-forming toxins...
- Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+J Richter
Department of Medicine, University Hospital, Lund, Sweden
Proc Natl Acad Sci U S A 87:9472-6. 1990..The generation of this Ca2+ signal may explain how adherence, by way of the integrins, changes the functional properties of the cell and enables TNF to induce secretion...
- Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectinJ M van den Berg
CLB, Sanquin Blood Supply Foundation and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 31:276-84. 2001..As transmigrated neutrophils are surrounded by both beta1 and beta2 ligands in the ECM, this integrin cross-talk could play a role in modifying migration and cellular activation in inflamed tissues...
- RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharidesJana Morova
Institute of Microbiology of the Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
Proc Natl Acad Sci U S A 105:5355-60. 2008..These results show that binding and killing of target cells by CyaA, LtxA, and HlyA depends on recognition of N-linked oligosaccharide chains of beta(2) integrin receptors. This sets a new paradigm for action of RTX cytotoxins...
- Bovine CD18 is necessary and sufficient to mediate Mannheimia (Pasteurella) haemolytica leukotoxin-induced cytolysisM S Deshpande
Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska 68583 0905, USA
Infect Immun 70:5058-64. 2002..There was a strong correlation between cell surface expression of bovine CD18 and percent cytotoxicity induced by Lkt. These results indicate that bovine CD18 is necessary and sufficient to mediate Lkt-induced cytolysis of target cells...
- Spontaneous skin ulceration and defective T cell function in CD18 null miceK Scharffetter-Kochanek
Department of Molecular and Human Genetics, Houston, Texas 77030, USA
J Exp Med 188:119-31. 1998..The null mice are useful for delineating the functions of CD18 in vivo...
- Actinobacillus actinomycetemcomitans leukotoxin requires lipid microdomains for target cell cytotoxicityKaren P Fong
The Leon Levy Research Center for Oral Biology, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
Cell Microbiol 8:1753-67. 2006..We propose that toxin-induced Ca2+ fluxes mobilize LFA-1 to lipid rafts where it associates with Ltx. These findings suggest that Ltx utilizes the raft to stimulate an integrin signalling pathway that leads to apoptosis of target cells...
- Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophilsChad E Green
Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
J Immunol 172:7780-90. 2004..Taken together, the data suggest that E-selectin is unique among selectins in its capacity for clustering sialylated ligands and transducing signals leading to neutrophil arrest in shear flow...
- Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2)R Mathison
Department of Physiology and Biophysics, Faculty of Medicine, The University of Calgary, AB, Canada
Can J Physiol Pharmacol 79:785-92. 2001..The inhibition by these tripeptides on neutrophil adhesion to myocytes suggests that salivary glands hormones regulate the severity of cardiac inflammation...
- The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)P Guermonprez
Unit of Biology of Immune Regulations, Institut Pasteur, Paris, France
J Exp Med 193:1035-44. 2001..Thus, the cellular distribution of CD11b, mostly on neutrophils, macrophages, and dendritic and natural killer cells, supports a role for CyaA in disrupting the early, innate antibacterial immune response...
- Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migrationJe Won Ryu
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Arterioscler Thromb Vasc Biol 24:864-70. 2004..Here we investigated whether UCP2 regulates expression of genes involved in monocyte recruitment...
- Locomotion of monocytes on endothelium is a critical step during extravasationAlan R Schenkel
Department of Pathology, Weill Medical College of Cornell University, Room C320, 1300 York Avenue, New York, New York 10021, USA
Nat Immunol 5:393-400. 2004..The blocked monocytes spun in circles as if they were unable to direct their movement despite being able to adhere and polarize normally. This step fills a gap in the paradigm of extravasation as a multistep process...
- Mannheimia (Pasteurella) haemolytica leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18R S Gopinath
Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0905, USA
Infect Immun 73:6179-82. 2005..Leukotoxin specifically lysed transfectants expressing bovine CD18 fragment encompassing amino acids 1 to 291, indicating that leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18...
- Recombinant expression of bovine LFA-1 and characterization of its role as a receptor for Mannheimia haemolytica leukotoxinThamotharampillai Dileepan
Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA
Microb Pathog 38:249-57. 2005..This is the first report on recombinant expression of functionally active bovine LFA-1 by transduction into an LktA-non-susceptible human cell line...
- Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligandsMichaeline Bunting
Program in Human Molecular Biology and Genetics, Huntsman Cancer Institute, Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, USA
Curr Opin Hematol 9:30-5. 2002....
- CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetesShayne C Barlow
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Am J Pathol 165:1849-52. 2004..This study demonstrates that the beta(2) integrins play a key pathophysiological role in the development of multiple low-dose streptozotocin-induced autoimmune diabetes...
- Increased CD11/CD18 expression and altered metabolic activity on polymorphonuclear leukocytes from patients with polycythemia vera and essential thrombocythemiaCarmen Burgaleta
Services of Hematology, Principe de Asturias, Department of Medicine, University of Alcala de Henares, Madrid, Spain
Acta Haematol 108:23-8. 2002..001). These data confirm the presence of a complex neutrophil dysfunction in PV and ET that probably reflects intrinsic abnormalities induced by changes in the cells' surface of the neoplastic clone and impaired signal transduction...
- Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migrationGuy Cinamon
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
J Immunol 173:7282-91. 2004....
- CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycansKe Zen
Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Immunol 169:5270-8. 2002..These findings implicate epithelial cell surface proteoglycans decorated with sulfated fucose moieties as ligands for CD11b/CD18 during PMN migration across mucosal surfaces...
- beta1 and beta2 integrins activate different signalling pathways in monocytesMerit Reyes-Reyes
Departamento de Inmunologia, Instituto de Investigaciones Biomedicas UNAM, Apto Postal 70228, Cd Universitaria, Mexico D F 04510, Mexico
Biochem J 363:273-80. 2002..These data suggest that distinct integrins activate different signalling pathways in monocytic cells...
- Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endotheliumRobert A Bowden
Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Circ Res 90:562-9. 2002..We conclude tissue-specific differences in endothelial cells account, at least partially, for CD18-independent neutrophil infiltration in the heart...
- LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivoSravanthi Kandula
Department of Medicine, Section of Gastroenterology, University of Chicago, Chicago, IL 60637, USA
J Immunol 173:4443-51. 2004..Taken together, these results demonstrate that LFA-1 is required for optimal CD4(+) T cell priming in vivo...
- Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune diseaseChristopher G Kevil
Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Am J Pathol 165:609-16. 2004..These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE...
- Manifestations of inflammatory arthritis are critically dependent on LFA-1Gerald M Watts
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:3668-75. 2005..Blocking mAbs further revealed an ongoing requirement for LFA-1 I-domain adhesive function in disease perpetuation. These findings suggest that the LFA-1 I-domain forms an attractive target for treatment of human inflammatory arthritis...
- The role of G-protein signaling in hematopoietic stem/progenitor cell mobilizationThalia Papayannopoulou
Division of Hematology, University of Washington, Seattle 98195, USA
Blood 101:4739-47. 2003..Collectively, our data unveil a novel example of mobilization through pharmacologic modulation of signaling...
- Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changesHuaizhu Wu
Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
J Immunol 173:297-306. 2004....
- Neutrophil string formation: hydrodynamic thresholding and cellular deformation during cell collisionsK E Kadash
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biophys J 86:4030-9. 2004....
- Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigrationYuan Liu
Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 277:10028-36. 2002..Taken together, these results demonstrate that PMN migration is regulated by CD47 through SIRPalpha-dependent and SIRPalpha-independent mechanisms...
- Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functionsC A Lowell
Department of Laboratory Medicine, University of California, San Francisco 94143, USA
J Cell Biol 133:895-910. 1996....
- E-selectin permits communication between PAF receptors and TRPC channels in human neutrophilsSarah R McMeekin
Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
Blood 107:4938-45. 2006....
- Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domainsK S Weber
Institut für Prophylaxe der Kreislaufkrankheiten, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
Mol Biol Cell 10:861-73. 1999..Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains...
- Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammationT B Issekutz
Department of Medicine, University of Toronto, Ontario, Canada
J Exp Med 183:2175-84. 1996..However, there exists an additional CD18- and VLA-4-independent pathway of neutrophil migration to arthritic joints that is not involved in acute dermal inflammation...
- Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivoDavid Frommhold
Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
BMC Immunol 8:31. 2007..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
- A role for beta(2) integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory responseB Walzog
Department of Physiology, Freie Universitat, D 14195 Berlin, Germany
FASEB J 13:1855-65. 1999..Altogether, the present findings provide evidence for a functional link between clotting and inflammatory responses that may contribute to the recruitment and/or activation of PMN and other cells at sites of lesion...
- Mannheimia haemolytica leukotoxin-induced cytolysis of caprine (Capra hircus) leukocytes is mediated by the CD18 subunit of beta2-integrinsT Fett
Department of Pathology, Faculty of Veterinary Medicine, University of Liege, FMV Sart Tilman B43, B 4000 Liege, Belgium
Microb Pathog 45:337-42. 2008..Taken together, these results indicate that CD18 on caprine leukocytes serves as a receptor for Lkt...
- CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbitsC M Doerschuk
University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
J Immunol 144:2327-33. 1990..However, PMN adherence in the pulmonary circulation may occur by either CD18-dependent or -independent mechanisms that are specific to the inciting stimulus...
- Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibilityThamotharampillai Dileepan
Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
FEMS Microbiol Lett 274:67-72. 2007..The results demonstrate unequivocally that the I-EGF-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to M. haemolytica leukotoxin...
- Bordetella adenylate cyclase toxin: a swift saboteur of host defenseJana Vojtova
Institute of Microbiology of the Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic
Curr Opin Microbiol 9:69-75. 2006..Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen...
- PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by beta(2)-integrin ligationL T Duong
Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Cell Motil Cytoskeleton 47:174-88. 2000..We propose that Pyk2 is functionally linked to the formation of podosomes where it mediates the integrin-cytoskeleton interface and regulates cell spreading and migration...
- Regulation of integrin function by the urokinase receptorY Wei
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Science 273:1551-5. 1996..These data provide a paradigm for regulation of integrins in which a nonintegrin membrane receptor interacts with and modifies the function of activated integrins...
- Vav GEFs are required for beta2 integrin-dependent functions of neutrophilsM Angelica Martinez Gakidis
Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
J Cell Biol 166:273-82. 2004..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis...
- Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathwayS I Simon
Speros Martel Section of Leukocyte Biology, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 164:4348-58. 2000..We conclude that neutrophils rolling on E-selectin undergo signal transduction leading to activation of cell arrest through beta 2 integrins binding to ICAM-1...
- A polygenic mouse model of psoriasiform skin disease in CD18-deficient miceD C Bullard
Department of Molecular, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 93:2116-21. 1996..This phenotype provides a model for inflammatory skin disorders, may have general relevance to polygenic human inflammatory diseases, and should help to identify genes that interact with the beta2 integrins in inflammatory processes...
- Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartmentJ W Huleatt
Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington 06030, USA
Immunity 5:263-73. 1996..These results demonstrated that ICAM-1 and beta2 integrins were required for establishment of a normal intestinal immune system...
- Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase FgrC M Vines
Department of Pathology and Cancer Research Facility, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Immunity 15:507-19. 2001..The inhibitory effects of Fgr are independent of its kinase activity, are dose dependent, and can be overcome by chemokines and inflammatory mediators...
- CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbitsR K Winn
Department of Surgery, University of Washington School of Medicine, Seattle 98104
J Clin Invest 92:1168-73. 1993..These studies demonstrate that: (a) early (4 h) PMN emigration is CD11/CD18 dependent; (b) late (24 h) PMN emigration is CD11/CD18 independent; and (c) mononuclear cells utilize the integrins CD18 and CD49d...
- Migration of human polymorphonuclear leukocytes through a synovial fibroblast barrier is mediated by both beta 2 (CD11/CD18) integrins and the beta 1 (CD29) integrins VLA-5 and VLA-6J X Gao
Department of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
Cell Immunol 163:178-86. 1995....
- Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product VavL Zheng
Department of Cell Biology, , Sweden
Proc Natl Acad Sci U S A 93:8431-6. 1996..Taken together, these results indicate that antibody-induced engagement of beta 2 integrins on neutrophils triggers tyrosine phosphorylation of Vav and, possibly through its association, a downstream activation of p21ras...
- Effects of intestinal lymph on expression of neutrophil adhesion factors and lung injury after trauma-induced shockZuo Bing Chen
Department of Emergency Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China
World J Gastroenterol 10:3221-4. 2004..To study how intestinal lymph after trauma-induced shock (TIS) interferes with expression of neutrophil adhesion factors (CD11b and CD18) and causes lung injury...
- Promotion of leukocyte adhesion by a novel interaction between vitronectin and the beta2 integrin Mac-1 (alphaMbeta2, CD11b/CD18)Sandip M Kanse
Institute for Biochemistry, Justus Liebig University, Giessen, Germany
Arterioscler Thromb Vasc Biol 24:2251-6. 2004..Until now, only an indirect interaction between Mac-1 and VN via the urokinase receptor (urokinase plasminogen activator receptor) was known. We now propose that Mac-1 and VN can directly interact with each other...
- Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophilsKe Zen
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 279:44924-30. 2004..Given the known sorting properties of BAP31, these findings suggest that BAP31 may play a role in regulating intracellular trafficking of CD11b/CD18 in neutrophils...
- Leukocyte-epithelial interactionsKe Zen
Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Boulevard, Room 1053, 615 Michael Street, Atlanta, GA 30322, USA
Curr Opin Cell Biol 15:557-64. 2003....
- Proinflammatory effects of copper deficiency on neutrophils and lung endothelial cellsDavid Lominadze
Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
Immunol Cell Biol 82:231-8. 2004..Combined, these results support the theory that dietary copper deficiency has proinflammatory effects on both neutrophils and the microvascular endothelium that promote neutrophil-endothelial interactions...
- Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophilsTarek Khreiss
Research Center, Maisonneuve Rosemont Hospital, and Department of Medicine, University of Montreal, 5415 Boulevard de l Assomption, Montreal, Quebec, Canada
Cell Signal 16:801-10. 2004..These results indicate that PAF-induced activation of ERK contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis, thereby amplifying the inflammatory response...
- Engagement of PSGL-1 enhances beta(2)-integrin-involved adhesion of neutrophils to recombinant ICAM-1Xiao guang Wang
Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
Acta Pharmacol Sin 27:617-22. 2006..Our present work aimed to investigate the mechanism by which PSGL-1-mediated signal activates neutrophils and enhances the adhesion to the endothelial cells...
- Expression of activation molecules in neutrophils, monocytes and lymphocytes from patients with unstable angina treated with stent implantationVictor Sanchez-Margalet
Department of Clinical Biochemistry, Virgen Macarena University Hospital, Seville, Spain
Clin Chem Lab Med 42:273-8. 2004....
- Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesionUlrich J H Sachs
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
Blood 104:727-34. 2004..In conclusion, some anti-Mart alloantibodies interfere with Mac-1-dependent cellular functions of neutrophils, cause NAIN, and may be used as tools for studying Mac-1-dependent functions...
- Polymorphonuclear leukocyte integrin profile in vascular atherosclerotic diseaseRosalia Lo Presti
Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universita di Palermo, Palermo, Italy
Clin Hemorheol Microcirc 30:53-60. 2004....
- Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on LPS-induced mesenteric microcirculatory disturbance in ratsJun Guo
Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China
Shock 29:205-11. 2008..Treatment with DLA or SAB significantly ameliorated LPS-induced microcirculatory disturbance in rat mesentery and inhibited both the expression of CD11b and CD18 and the production of *O2- and H2O2 by neutrophils caused by LPS...
- Ovarian cancer cells modulate human blood neutrophils response to activation in vitroM Klink
Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
Scand J Immunol 68:328-36. 2008..Our results suggest the possibility that neutrophils responding to contact with cancer cells contribute to the progression and metastatic potential of tumour cells...
- Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2Dmitry A Solovjov
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 280:1336-45. 2005..These data indicate that each subunit of alphaMbeta2 contributes distinct properties to alphaMbeta2 and that, in most but not all cases, the response of the integrin is a composite of the functions of its individual subunits...
- Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in diabetic mice with sepsisWan Chun Chiu
Graduate Institute of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan, ROC
Br J Nutr 97:685-91. 2007..The present findings suggest that compared with the diabetic mice fed SO, a low-dose n-3 fatty acid supplementation may attenuate leucocyte adhesion and infiltration into tissues in diabetic mice complicated with sepsis...
- Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18Dale J Powner
CRUK Institute for Cancer Studies, The Medical School, The University of Birmingham, Birmingham, B15 2TT, UK
Mol Immunol 44:3211-21. 2007..Thus, these data indicate that PLD-synthesised PtdOH stimulates the generation of PtdIns(4,5)P(2), which in turn mediates talin binding to, and activation of, CD11b/CD18 required for neutrophil stable adhesion and migration...
- Src family kinases mediate neutrophil adhesion to adherent plateletsVirgilio Evangelista
Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
Blood 109:2461-9. 2007..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...
- Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In VivoPaul S Frenette; Fiscal Year: 2013..These studies will provide new insight on the mechanisms regulating sickle cell VOC and lead to novel ways to target inflammation. ..
- Very Late Antigen Integrin Activity on T CellsYoji Shimizu; Fiscal Year: 2010....
- Beta2 Integrin Activation and SignalingVineet Gupta; Fiscal Year: 2010..The insights gained from these studies are also likely to extend to other integrins. ..
- Oral Pathogen Exploitation of Innate Recognition as a Function of AgeGEORGIOS HAJISHENGALLIS; Fiscal Year: 2011....
- Molecular Basis of Mo1 LFA 1 DeficiencyM Amin Arnaout; Fiscal Year: 2013..Biochemical, immunochemical, genetic and structural approaches and animal models will be utilized by a multidisciplinary group of investigators to achieve these goals. ..
- Multiscale modeling of leukocyte-tumor cell adhesion to endothelium in shear flowCheng Dong; Fiscal Year: 2010....
- ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMANicholas Vedder; Fiscal Year: 2000..These studies should yield new insights into the basic mechanisms of neutrophil-endothelial interactions in reperfusion injury and potentially suggest new therapeutic strategies to a wide range of important disease processes. ..
- Hemostatic Factors and Tumor BiologyJoseph Palumbo; Fiscal Year: 2007..The planned program will provide the record of productivity, knowledge and skills necessary to establish a successful career as an independent physician/scientist. ..
- Selectin Control of Leukocyte Adhesion in ShearMichael Lawrence; Fiscal Year: 2006..Such insight may lead to identification of more effective molecular targets for anti-inflammatory therapeutics. ..
- T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITISJeffrey Curtis; Fiscal Year: 2002..Our long-term goal is to develop effective therapies to treat established SLE based on anti-adhesive strategies. ..
- INTEGRIN ASSOCIATED PROTEIN IS A THROMBOSPONDIN RECEPTORWilliam Frazier; Fiscal Year: 2000..This work can potentially yield information and compounds of therapeutic value in hemostasis and thrombosis, wound healing, angiogenesis and inflammatory diseases such as arthritis. ..
- INTEGRINS AND PMN MOTILITYWILLIAM HENDEY; Fiscal Year: 2000..Finally, relationship between beta2 phosphorylation and beta3-mediated attachment or detachment will be assessed. ..
- BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILSMimi Takami; Fiscal Year: 2003..And, as a biological model, we will explore the way in which exposure to Helicobacter pylori, may impact these signals and affect neutrophil adhesion and migration on epithelial surfaces. ..
- Intercellular Signaling in Obstructive NephropathyROBERT CHEVALIER; Fiscal Year: 2005..This will lead to improved outcomes in adulthood. ..
- HTS Assay for Discovery:Small Molecule Regulators (RMI)Vineet Gupta; Fiscal Year: 2005..Given the central role of beta2 integrins in regulating leukocyte function, we hope that this research will provide important new tools and further guide future experimentation. ..
- ISOLATED PSGL-1 AND MAC-1 ADHESION TO ENDOTHELIUMDOUGLAS GOETZ; Fiscal Year: 2003..abstract_text> ..
- CD11B/CD18 AND NEUTROPHIL EPITHELIAL INTERACTIONSCHARLES PARKOS; Fiscal Year: 2003..abstract_text> ..
- BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILSMimi Takami; Fiscal Year: 2003..We will examine the relationship of these events to the complex shape changes involved in aggrevated and transmigration. ..
- GENETIC MOUSE MODELS FOR CHRONIC INFLAMMATORY DISEASEDaniel Bullard; Fiscal Year: 2006..abstract_text> ..
- CONDITIONAL B INTEGRIN BLOCKADE, PMN TRAFFICKINGASRAR MALIK; Fiscal Year: 2004..abstract_text> ..
- VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURYJames Frank; Fiscal Year: 2006..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
- THE PROTEIN C RECEPTOR AND WEGENER'S VASCULOPATHYShinichiro Kurosawa; Fiscal Year: 2003..In addition, the results will provide a foundation for future studies investigating potential therapeutic targets that modulate neutrophil-mediated endothelial injury, particularly for cANCA-mediated vasculitis. ..
- CONTACT DEPENDENT ENDOTHELIAL ACTIVATION BY NK CELLSJeffrey Bender; Fiscal Year: 2003..This work may provide direction for pharmacologic and/or genetic manipulations, thereby interfering with endothelial activation and immune-mediated vasculopathy in clinical transplants. ..
- PMN MOTILITY AND ADHERENCE IN NEONATESC Smith; Fiscal Year: 1999..This involves assessment of acute inflammation in response to nonspecific stimuli, evaluation of the adhesion cascade using intravital microscopy, and responses to specific bacteria (e.g., group B Streptococcus). ..
- THE REGULATION OF BETA-2 INTEGRIN FUNCTIONLLOYD KLICKSTEIN; Fiscal Year: 2004..A further understanding of how lymphocytes regulate adhesion will lead to new strategies for the development of anti-inflammatory therapies with potential applications in autoimmune disease and transplantation medicine. ..
- PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATIONWilliam Muller; Fiscal Year: 2003..We have generated mice that are genetically deficient in PECAM and mice in which PECAM does not function. These mice will be critical to evaluate PECAM-independent TEM. ..
- PMN integrins, apoptosis and inflammationWILLIAM HENDEY; Fiscal Year: 2007..An understanding of this pathway would provide novel targets for the control of inflammation. ..
- GENES ENCODING T CELL RECEPTORSEllis Reinherz; Fiscal Year: 2006..Third, the molecular mechanism by which the CD2 cytoplasmic tail interacting proteins CD2BP1, CD2BP3 and CD2BP4 affect cell motility, polarity and lipid biogenesis will be investigated. ..
- BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLSThalia Papayannopoulou; Fiscal Year: 2009..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
- Resolution of Gouty InflammationSTEPHEN MALAWISTA; Fiscal Year: 2008..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
- GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATIONThalia Papayannopoulou; Fiscal Year: 2002....
- LYME DISEASE--HOST PARASITE INTERACTIONSSTEPHEN MALAWISTA; Fiscal Year: 2003..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
- Role of CIC-3 channels in regulation of cell volume and shape in neutrophilsJessica Moreland; Fiscal Year: 2007..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
- NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASEJessica Moreland; Fiscal Year: 2004....
- Mechanisms of Eosinophil AdhesionXiangdong Zhu; Fiscal Year: 2006..Knowledge of the signaling components required for eosinophil adhesion may provide insight into the pathogenesis of airway inflammation and lead to therapeutic interventions for human asthma. ..
- CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASEMichael Roth; Fiscal Year: 2009..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
- Development of Novel Regimens for the Prevention of Chronic Renal FailureCARL SHELLEY; Fiscal Year: 2008..In this way we expect to provide proof-of-principal for new therapeutic regimens that reduce the ability of hypoxia to cause CRF. ..
- UCSD Hillcrest Flow CytometerPaul Mills; Fiscal Year: 2003..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
- DIFFUSION MRI AS BIOMARKER FOR THERAPY RESPONSE IN BREAST CANCER METASTASESAlison T Stopeck; Fiscal Year: 2010....
- Lipid Raft Microdomains in Neutrophil FunctionROBERT GARY SITRIN; Fiscal Year: 2010..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
- Interferon Regulation in Systemic LupusLionel B Ivashkiv; Fiscal Year: 2010..These experiments will yield insight into the molecular pathogenesis of SLE and identify novel therapeutic approaches to manipulatecytokine activity in SLE at the level of signal transduction. ..
- THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSESMARGARET GYETKO; Fiscal Year: 2003..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
- Dynamic Strenghts of Leukoctye Adhesion BondsEvan A Evans; Fiscal Year: 2011..abstract_text> ..
- SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESIONPaul J Mills; Fiscal Year: 2010..abstract_text> ..
- Acute renal failure after whole body ischemiaHamid Rabb; Fiscal Year: 2008..Our long-term goals are to develop a clinically relevant experimental model which can be used to develop novel therapies for ARF. [unreadable] [unreadable] [unreadable]..
- RR-03-011, Extramural Research Facilities Construction *Dallas Hyde; Fiscal Year: 2004..Construction of the proposed facility will permit consolidation of existing research activities with human pathogens in modern BSL-2 and BSL-3 containment. ..
- Anthrax Vaccine Formulations Combining PA/Spore EpitopesAAIYAPPA PALECANDA; Fiscal Year: 2005..Significance: This research is relevant to the potential to develop novel vaccine formulations and therapeutics to counter inhalation anthrax. ..
- MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 2004..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
- Roles for coagulation in immunitySTEPHEN SMILEY; Fiscal Year: 2005..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
- Adjuvant immunotherapy for non-small cell lung cancerMichael Roth; Fiscal Year: 2005..abstract_text> ..
- REGULATION OF MICROVASCULAR PERMEABILITY BY NITRIC OXIDEROLANDO RUMBAUT; Fiscal Year: 2004..The long-term goal is to apply the knowledge gained from these studies to allow optimal management of patients with these important clinical entities and their associated microvascular alterations. ..
- Biomechanics on Neutrophil Rolling on the EndotheliumJin Yu Shao; Fiscal Year: 2006..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
- The Urokinase-CD87 System in Macrophage ActivationRobert Sitrin; Fiscal Year: 2004....
- EXTRAVASCULAR TRAFFICKING OF HIV+ CELLS AND PROGNOSISHolly Birdsall; Fiscal Year: 2003....
- Pericytes in Pathogenesis of Germinal-Matrix HemorrhagePraveen Ballabh; Fiscal Year: 2006..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
- Chemokine Receptor Chimeras by Synthetic Gene LibraryMichael Dustin; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISMS OF NOVEL ANTI-INFLAMMATORY ACTIONS OF SLPIAihao Ding; Fiscal Year: 2007..unreadable] [unreadable]..
- MRFASS--MINORITIES, RISK FACTOR AND STROKE STUDYStanley Tuhrim; Fiscal Year: 2003..Stroke-free survival rates will be estimated for each ethnic group and the independent determinants of recurrence will be identified with multivariate statistical techniques. ..
- Vector-based Generation of Monoclonal Antibodies against the CB2 ReceptorMichael Roth; Fiscal Year: 2007..This work has the capacity to significantly accelerate cannabinoid research. [unreadable] [unreadable] [unreadable]..
- ImmunoreceptorsMichael Dustin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..