cd14 antigens

Summary

Summary: Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.

Top Publications

  1. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
  2. ncbi CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    S D Wright
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    Science 249:1431-3. 1990
  3. ncbi Human CD14 mediates recognition and phagocytosis of apoptotic cells
    A Devitt
    Department of Immunology, University of Birmingham Medical School, UK
    Nature 392:505-9. 1998
  4. ncbi Peripheral blood CD14high CD16+ monocytes are main producers of IL-10
    J Skrzeczynska-Moncznik
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland
    Scand J Immunol 67:152-9. 2008
  5. ncbi Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
    J da Silva Correia
    Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    J Biol Chem 276:21129-35. 2001
  6. ncbi Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    A Haziot
    Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
    Immunity 4:407-14. 1996
  7. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
  8. ncbi Tlr4: central component of the sole mammalian LPS sensor
    B Beutler
    Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Curr Opin Immunol 12:20-6. 2000
  9. ncbi Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations
    T Muta
    Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Biochem 268:4580-9. 2001
  10. ncbi A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance
    Tanja D de Gruijl
    Department of Medical Oncology, Division of Immunotherapy, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 176:7232-42. 2006

Detail Information

Publications234 found, 100 shown here

  1. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
    ..The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease...
  2. ncbi CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    S D Wright
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    Science 249:1431-3. 1990
    ..Thus, LPS may induce responses by interacting with a soluble binding protein in serum that then binds the cell surface protein CD14...
  3. ncbi Human CD14 mediates recognition and phagocytosis of apoptotic cells
    A Devitt
    Department of Immunology, University of Birmingham Medical School, UK
    Nature 392:505-9. 1998
    ..These results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with 'non-self' components (LPS) and 'self' components (apoptotic cells) produce distinct macrophage responses...
  4. ncbi Peripheral blood CD14high CD16+ monocytes are main producers of IL-10
    J Skrzeczynska-Moncznik
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland
    Scand J Immunol 67:152-9. 2008
    ..In conclusion, our data show that human peripheral blood CD16(+) MO are heterogeneous in function and consist of two subpopulations: CD14(dim) CD16(+) pro-inflammatory and CD14(high) CD16(+) with anti-inflammatory potential...
  5. ncbi Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
    J da Silva Correia
    Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    J Biol Chem 276:21129-35. 2001
    ..These data support the contention that LPS is in close proximity to the three known proteins of its membrane receptor complex. Thus, LPS binds directly to each of the members of the tripartite LPS receptor complex...
  6. ncbi Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    A Haziot
    Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
    Immunity 4:407-14. 1996
    ..Surprisingly, CD14-deficient mice also showed dramatically reduced levels of bacteremia, suggesting an unexpected role for CD14 in the dissemination of Gram-negative bacteria...
  7. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
    ....
  8. ncbi Tlr4: central component of the sole mammalian LPS sensor
    B Beutler
    Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Curr Opin Immunol 12:20-6. 2000
    ..The structurally related protein Tlr2 makes no contribution to LPS signal transduction...
  9. ncbi Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations
    T Muta
    Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Biochem 268:4580-9. 2001
    ..Supporting its functional significance, both receptors are found to associate with CD14...
  10. ncbi A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance
    Tanja D de Gruijl
    Department of Medical Oncology, Division of Immunotherapy, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 176:7232-42. 2006
    ....
  11. ncbi Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    Ainsley M Sutherland
    University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
    Crit Care Med 33:638-44. 2005
    ....
  12. ncbi Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteins
    Han Jae Shin
    Department of Biochemistry, Chungnam National University, Daejeon 305 764, Korea
    Mol Cells 24:119-24. 2007
    ..28 10 2 S 1, revealing slow association and fast dissociation with an affinity constant KD of 2.33 x 10-6 M at 25 degreesC. These affinities are consistent with the current view that CD14 conveys LPS to the TLR4/MD-2 complex...
  13. ncbi CD14 signalling in lipid rafts: new ligands and co-receptors
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Curr Opin Lipidol 13:513-21. 2002
    ..The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis...
  14. pmc Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
    J Exp Med 196:1017-24. 2002
    ..We conclude that yersiniae might exploit host innate pattern recognition molecules and defense mechanisms to evade the host immune response...
  15. ncbi Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohort
    C Sengler
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Clin Exp Allergy 33:166-9. 2003
    ..Recently, a functional CD14 promoter polymorphism was related to total and specific IgE responsiveness...
  16. ncbi Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    A O Aliprantis
    Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 285:736-9. 1999
    ..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms...
  17. pmc Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14
    M O Labeta
    Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XX, United Kingdom
    J Exp Med 191:1807-12. 2000
    ....
  18. ncbi Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
    ..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...
  19. ncbi Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load
    Lynn Pulliam
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Neuroimmunol 157:93-8. 2004
    ..We concluded that there is a circulating CD14+ macrophage hybrid phenotype in subjects with HVL...
  20. pmc Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells
    F Geissmann
    Service d Anatomie Pathologique, Hopital Necker Enfants Malades, Paris, France
    J Exp Med 187:961-6. 1998
    ..e., the monocyte, in response to a TGF-beta1-rich microenvironment, as found in the skin and epithelia. Therefore, the monocyte may represent a circulating precursor critical to the immune response in vivo...
  21. ncbi Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
    R B Yang
    Department of Molecular Biology, Genentech, South San Francisco, California 94080 4990, USA
    Nature 395:284-8. 1998
    ..Our results indicate that TLR2 is a direct mediator of signalling by LPS...
  22. ncbi Evaluation of CD14 in host defence
    P Antal-Szalmas
    Utrecht University, The Netherlands, and University Medical School of Debrecen, Hungary
    Eur J Clin Invest 30:167-79. 2000
    ....
  23. pmc Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins
    R L Kitchens
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 108:485-93. 2001
    ..In human plasma, sCD14 thus diminishes monocyte responses to LPS by transferring cell-bound LPS to lipoproteins. Stress-related increases in plasma sCD14 levels may help prevent inflammatory responses within the blood...
  24. ncbi CD14 is an acute-phase protein
    Sylvette Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    J Immunol 172:4470-9. 2004
    ..Liver levels of CD14 mRNA increased in IL-6(+/+), but not in IL-6(-/-) mice. These results indicate that sCD14 can be considered as a type 2 APP...
  25. ncbi The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF
    Kai Uwe Belge
    Institute for Immunology, University of Muenchen, Germany
    J Immunol 168:3536-42. 2002
    ..This indicates that the minor population of CD14(+)CD16(+) monocytes are major producers of TNF in human blood...
  26. pmc Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progression
    Antoinette C van der Kuyl
    Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e257. 2007
    ..CD169 is highly expressed by macrophages present in AIDS-related Kaposi's sarcoma lesions. It is also increased on blood monocytes of HIV-1 infected patients with a high viral load despite antiretroviral treatment...
  27. ncbi CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserine
    A Devitt
    MRC Center for Inflammation Research, University of Edinburgh, UK
    Cell Death Differ 10:371-82. 2003
    ..The additional features that enable apoptotic-cell clearance are derived from mechanisms that can be divorced temporally from those responsible for the morphological features of apoptosis...
  28. ncbi MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor
    Jean da Silva Correia
    Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    J Biol Chem 277:1845-54. 2002
    ....
  29. ncbi TLR4 as the mammalian endotoxin sensor
    B Beutler
    Department of Immunology, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 270:109-20. 2002
    ..The fact that LPS signals are elicited through a single biochemical pathway has raised important pharmacotherapeutic opportunities as well...
  30. pmc Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, USDA Agricultural Research Service ANRI, BARC East, Bldg 1040, Room 2, Beltsville, MD 20705 2350, USA
    Clin Diagn Lab Immunol 11:463-72. 2004
    ..coli and S. aureus and suggest that the limited cytokine response to S. aureus may contribute to the well-known ability of the bacterium to establish chronic intramammary infection...
  31. pmc Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
    Infect Immun 73:1754-63. 2005
    ....
  32. ncbi Endotoxin recognition molecules, Toll-like receptor 4-MD-2
    Kensuke Miyake
    Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    Semin Immunol 16:11-6. 2004
    ..MD-2 has a role in cell surface expression of TLR4 and interaction with LPS. TLR4-MD-2 contributes to containment of infections by Gram-negative bacteria by activating immune responses...
  33. pmc Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis
    Kristine Marie Jessen
    Clinical Research Unit, Hvidovre University Hospital, Copenhagen, Denmark
    BMC Infect Dis 7:108. 2007
    ..Only few studies have combined the analysis of multiple SNPs in the same population...
  34. pmc Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
    J D Lee
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    J Exp Med 175:1697-705. 1992
    ..These data provide evidence to support the concept that the LPS receptor in cells that constitutively express CD14 may be a multiprotein complex containing CD14 and membrane protein(s) common to a diverse group of LPS-responsive cells...
  35. ncbi Interaction of polymorphisms in the CARD15 and CD14 genes in patients with Crohn disease
    W Klein
    Abteilung für Humangenetik, Ruhr Universitat, Bochum, Germany
    Scand J Gastroenterol 38:834-6. 2003
    ..These variations are neither necessary nor sufficient for the genetic predisposition of CD. Further genetic and environmental factors play a crucial role in the pathogenesis of CD...
  36. ncbi The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors
    S M Goyert
    Department of Rheumatic Diseases, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003
    Science 239:497-500. 1988
    ..In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias...
  37. ncbi CD14 is a cell-activating receptor for bacterial peptidoglycan
    D Gupta
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
    J Biol Chem 271:23310-6. 1996
    ....
  38. ncbi LPS induction of gene expression in human monocytes
    M Guha
    Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 13:85-94. 2001
    ..These signaling pathways in turn activate a variety of transcription factors that include NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun), which coordinate the induction of many genes encoding inflammatory mediators...
  39. ncbi Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    Yong Han Paik
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Hepatology 37:1043-55. 2003
    ..In conclusion, human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF-kappaB and JNK and up-regulate chemokines and adhesion molecules. Thus, HSCs are a potential mediator of LPS-induced liver injury...
  40. ncbi Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection
    S Auffermann-Gretzinger
    Divisions of Oncology and of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305-5151, USA
    Blood 97:3171-6. 2001
    ..Blood. 2001;97:3171-3176)..
  41. ncbi CD14 is required for MyD88-independent LPS signaling
    Zhengfan Jiang
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Immunol 6:565-70. 2005
    ..Thus, the TLR4-MD-2 complex receptor can function in two separate modes: one in which full signaling occurs and one limited to MyD88-dependent signaling...
  42. ncbi CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 161:6250-7. 1998
    ..A maximum of 70% inhibition was achieved by combining anti-CD36 with either anti-a(v) or PS liposomes...
  43. pmc Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14
    B Neumeister
    Abteilung Transfusionsmedizin der Universität Tübingen, AG Infektionsimmunologie, D 72076 Tubingen, Germany
    Infect Immun 66:4151-7. 1998
    ..Our results suggest that the low endotoxic potential of LPS-Lp is due to a failure of interaction with the LPS receptor CD14...
  44. ncbi The presence of functional mannose receptor on macrophages at the maternal-fetal interface
    G Laskarin
    Department of Physiology and Immunology, School of Medicine, University of Rijeka, B Branchetta 20 1, 51000 Rijeka, Croatia
    Hum Reprod 20:1057-66. 2005
    ..The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling...
  45. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004
    ..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
  46. pmc Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14
    Sachiko Akashi
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    J Exp Med 198:1035-42. 2003
    ..These results reveal direct LPS interaction with cell surface TLR4-MD-2 that is distinct from that with MD-2 or CD14...
  47. ncbi Reduced early alcohol-induced liver injury in CD14-deficient mice
    M Yin
    Department of Pharmacology, Laboratory of Hepatobiology and Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 166:4737-42. 2001
    ..Thus, chronic ethanol feeding caused more severe liver injury in wild-type than CD14 knockouts, supporting the hypothesis that endotoxin acting via CD14 plays a major role in the development of early alcohol-induced liver injury...
  48. ncbi CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol
    P Y Perera
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 158:4422-9. 1997
    ....
  49. ncbi Dendritic cells in the human decidua
    Lucy Gardner
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Biol Reprod 69:1438-46. 2003
    ..They were also visible in endothelial-lined spaces. This is the first study to identify and describe the phenotype and distribution of human decidual DCs...
  50. ncbi CD14-dependent airway neutrophil response to inhaled LPS: role of atopy
    N Alexis
    Center for Environmental Medicine and Lung Biology, Department of Pediatrics, University of North Carolina-Chapel Hill, 27599-7310, USA
    J Allergy Clin Immunol 107:31-5. 2001
    ..CONCLUSION: Constitutive airway CD14 expression can predict the magnitude of the PMN response after inhaled LPS. Atopy appears to play a role in the level of CD14 expression and may contribute to LPS sensitivity in asthmatic subjects...
  51. ncbi Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection
    R S Jack
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat Greifswald, Germany
    Nature 389:742-5. 1997
    ....
  52. ncbi Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:15587-94. 2003
    ..However, the involvement of TLR-4 and MD-2 in this process was ruled out...
  53. pmc Phenotypic characterization of human decidual macrophages
    J Heikkinen
    Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
    Clin Exp Immunol 131:498-505. 2003
    ..Furthermore, decidual macrophages were not able to differentiate into dendritic cells under the influence of IL-4 + GM-CSF. These results suggest an immunoinhibitory function of decidual macrophages at the maternal-fetal interface...
  54. ncbi A polymorphism in the promoter of the CD14 gene (CD14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki disease
    Shinji Nishimura
    Department of Pediatrics, Faculty of Medicine, Saga Medical School, and the Division of Pediatrics, Saga Prefectural Hospital Koseikan, Saga, Japan
    J Pediatr 143:357-62. 2003
    ..To investigate whether a polymorphism in the CD14 gene is associated with Kawasaki disease (KD)...
  55. ncbi CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 40:34-42. 2002
    ..We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation...
  56. ncbi The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus
    Daisuke Iwaki
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 277:24315-20. 2002
    ..In addition, we found that sCD14 interacted with sTLR2 and increased the binding of sTLR2 to iPGN. From these results, we conclude that the extracellular TLR2 domain directly binds to PGN...
  57. pmc The CD14 functional gene polymorphism -260 C>T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology
    Sander Ouburg
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Infect Dis 5:114. 2005
    ..We investigated the role of the CD14 -260 C>T polymorphism in the susceptibility to and severity (defined as subfertility and/or tubal pathology) of C. trachomatis infection in Dutch Caucasian women...
  58. pmc Secretory leukocyte protease inhibitor interferes with uptake of lipopolysaccharide by macrophages
    A Ding
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Infect Immun 67:4485-9. 1999
    ..These results suggest that the inhibitory effect of SLPI on macrophage responses to LPS may, in part, be due to its blockade of LPS transfer to soluble CD14 and its interference with uptake of LPS from LPS-sCD14 complexes by macrophages...
  59. ncbi Phenotypic and functional characteristics of circulating monocytes of elderly persons
    H M Sadeghi
    Center for Interdisciplinary Research in Immunology and Disease and the Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90024 1747, USA
    Exp Gerontol 34:959-70. 1999
    ..Such age-related alterations in monocytes may contribute to impaired immune competence of aging...
  60. ncbi CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection
    Hakim Echchannaoui
    Department of Research, University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Leukoc Biol 78:705-15. 2005
    ..In conclusion, CD14 plays a protective role in pneumococcal meningitis by slowing PMN migration via MIP-2 and CXCR2 modulation...
  61. ncbi Legionella pneumophila mediated activation of dendritic cells involves CD14 and TLR2
    Sibylla Braedel-Ruoff
    Interfakultäres Institut für Zellbiologie der Universität Tübingen, Abteilung Immunologie, Tubingen, Germany
    J Endotoxin Res 11:89-96. 2005
    ..Our data show that not only purified LPS from L. pneumophila but also the microorganism itself stimulate BMDCs via TLR2 and that this stimulation is dependent on CD14 in this mouse model...
  62. pmc Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia
    S Liu
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Infect Immun 66:5089-98. 1998
    ..Our observations also support the idea that soluble CD14 is an acute-phase protein and that hepatocytes could be a source for soluble CD14 production...
  63. ncbi Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes
    S Liu
    Department of Surgery, University of Pittsburgh School of Medicine, PA 15261, USA
    Gene 250:137-47. 2000
    ..These data provide novel insights into the regulation of basal CD14 expression in liver cells...
  64. ncbi A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity
    T D LeVan
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Immunol 167:5838-44. 2001
    ..Variation in a key gene of innate immunity may be important for the pathogenesis of allergy and inflammatory disease through gene-by-gene and/or gene-by-environment interactions...
  65. ncbi Modulatory effects of sCD14 and LBP on LPS-host cell interactions
    Richard L Kitchens
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Endotoxin Res 11:225-9. 2005
    ....
  66. ncbi CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes
    R A Schlegel
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania 16802, USA
    Cell Death Differ 6:583-92. 1999
    ....
  67. ncbi Dermal-resident CD14+ cells differentiate into Langerhans cells
    A T Larregina
    Department of Dermatology and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 USA
    Nat Immunol 2:1151-8. 2001
    ..Identification and characterization of these LC precursors provided insight into LC biology and the mechanism(s) through which LCs repopulate the epidermis...
  68. ncbi Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis
    K M Lammers
    Department Internal Medicine and Gastroenterology, Policlinic S Orsola, University of Bologna, Nuove patologie Pad 5, Via Massarenti 9, 40138 Bologna, Italy
    World J Gastroenterol 11:7323-9. 2005
    ..To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity...
  69. ncbi Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1
    D Gupta
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
    J Biol Chem 274:14012-20. 1999
    ..This is the first study to demonstrate activation of CREB/ATF and AP-1 transcription factors by PGN or by any other component of Gram-positive bacteria...
  70. pmc Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus
    Shan Herath
    Royal Veterinary College, Department of Veterinary Clinical Sciences, University of London, North Mymms, Hatfield, Hertfordshire AL9 7TA, United Kingdom
    Endocrinology 147:562-70. 2006
    ..In conclusion, epithelial and stromal cells detect and respond to bacteria, which modulate their endocrine function...
  71. ncbi CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex
    Takashi Nakata
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Nishi 7, Kita 13, Kita ku, Sapporo 060 8586, Japan
    Cell Microbiol 8:1899-909. 2006
    ..7 microM. This study suggests that CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the TLR2/TLR1 complex without binding to the receptor complex...
  72. pmc Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3
    Torsten Stein
    Division of Cancer Sciences and Molecular Pathology, Western Infirmary, Glasgow, UK
    Breast Cancer Res 6:R75-91. 2004
    ..Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process...
  73. ncbi Involvement of microbial components and toll-like receptors 2 and 4 in cytokine responses to air pollution particles
    Susanne Becker
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA
    Am J Respir Cell Mol Biol 27:611-8. 2002
    ..In contrast, E5531 had no effect on the response to Staphylococcus. Taken together, these results implicate microbial components as important players in AM-dependent inflammatory responses to PM...
  74. ncbi Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
    Doreen M Agnese
    Division of Surgical Sciences, Department of Surgery, University of Medicine and Dentistry New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Infect Dis 186:1522-5. 2002
    ..These findings indicate that hTLR4 mutations are associated with an increased incidence of gram-negative infections in critically ill patients in a surgical setting...
  75. ncbi The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo
    Philip J Ellery
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Immunol 178:6581-9. 2007
    ..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART...
  76. pmc Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 183:2678-87. 2009
    ..Our study demonstrates that functional CD14(+)CD16(-) and CD14(+)CD16(+) monocytes can be isolated from allogeneic hematopoietic stem cell transplantation donors and that these subsets differ in their response to A. fumigatus conidia...
  77. ncbi Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
    Eicke Latz
    University of Massachusetts Medical School, Division of Infectious Diseases, Worcester 01605, USA
    J Biol Chem 277:47834-43. 2002
    ..Golgi-associated TLR4 expression was disrupted by brefeldin A, yet LPS signaling was preserved. We conclude that LPS signaling may be initiated by surface aggregation of TLR4 and is not dependent upon LPS trafficking to the Golgi...
  78. ncbi Differential chemokine receptor expression and function in human monocyte subpopulations
    C Weber
    Institute for Prevention of Cardiovascular Disease, Ludwig Maximilians University, Munchen, Germany
    J Leukoc Biol 67:699-704. 2000
    ..The characteristics of CD14+CD16+ cells may reflect preactivation by cytokines and determine their predilective localization during specific inflammatory conditions or susceptibility to infection...
  79. ncbi alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro
    Izabela M Nita
    Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, Lund University, SE 20502 Malmo, Sweden
    Int J Biochem Cell Biol 39:1165-76. 2007
    ..These findings provide evidence that AAT is an important regulator of CD14 expression and release in monocytes and suggest that AAT may be involved in LPS neutralization and prevention of over-activation of monocytes in vivo...
  80. ncbi Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
    ..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
  81. ncbi Divergent response to LPS and bacteria in CD14-deficient murine macrophages
    K J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 165:4272-80. 2000
    ..coli. These data indicate that CD14 is essential for macrophage responses to free LPS, whereas other receptors, including CD11b/CD18, can compensate for the loss of CD14 in response to whole bacteria...
  82. ncbi Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    Yoshinori Nagai
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Immunol 3:667-72. 2002
    ..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
  83. ncbi CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae
    Mark C Dessing
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 175:604-11. 2007
    ..Knowledge of the contribution of CD14 to host defense against gram-positive infections is limited...
  84. ncbi Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4
    A E Medvedev
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 167:2257-67. 2001
    ..Thus, tolerance to LPS and mycobacterial components cannot be attributed solely to a decrease in TLR/MD-2 expression levels, suggesting inhibition of expression or function of other signaling intermediates...
  85. ncbi CD14 is an essential mediator of LPS-induced airway disease
    David M Brass
    National Institute of Environmental Health Sciences, Rall Bldg, Rm C224, PO Box 12233 MD C2 15, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 293:L77-83. 2007
    ....
  86. ncbi The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 175:6042-9. 2005
    ..These data suggest that the MyD88-dependent pathway of TLR4 is important for an effective innate immune response to respiratory tract infection caused by NTHi...
  87. ncbi Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    C Werts
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 2:346-52. 2001
    ..These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2...
  88. ncbi Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC
    Holger Heine
    Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
    Eur J Biochem 270:440-50. 2003
    ..Like other LPS, the chlamydial LPS used toll-like receptor TLR4 for signalling, but unlike other LPS activation was strictly CD14-dependent...
  89. ncbi Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection
    C Meiler
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 11:6031-7. 2005
    ..Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD) and chronic hepatitis C virus (HCV) infection...
  90. ncbi MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytes
    Norihiko Sakai
    Department of Gastroenterology and Nephrology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Leukoc Biol 79:555-63. 2006
    ..These data suggest that fibrogenic processes in Mo regulated by MCP-1/CCR2 may be novel, therapeutic targets for combating organ fibrosis...
  91. ncbi CD14 promoter polymorphism -159C>T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes
    J Rupp
    Institute of Medical Microbiology and Hygiene, University of Luebeck, Germany
    Genes Immun 5:435-8. 2004
    ..Susceptibility for chronic chlamydial infection of PBMC in CAD patients appears associated with the CD14-159C>T promoter polymorphism encoding for enhanced CD14 expression...
  92. ncbi Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine Academic Medical Center, University of Amsterdam, Meibergdreef 9, G2 132, 1105 AZ Amsterdam, The Netherlands
    Am J Respir Crit Care Med 173:122-9. 2006
    ..baumannii infection have not been elucidated...
  93. ncbi Correlation between human immunodeficiency virus type 1 RNA levels in the female genital tract and immune activation associated with ulceration of the cervix
    S D Lawn
    Tuberculosis and Mycobacteriology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 181:1950-6. 2000
    ..We suggest that local immune activation increases HIV-1 load in genital secretions, potentially increasing the risk of HIV-1 transmission...
  94. ncbi Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex
    Sophie C Gangloff
    North Shore LIJ Research Institute New York University School of Medicine, Manhasset, NY 11030, USA
    J Immunol 175:3940-5. 2005
    ..Thus, CD14(+/+), but not CD14(-/-), macrophages are highly sensitive to stimulation by natural forms of LPS and show the ability to distinguish between various LPS ligands, consistent with CD14 being a highly specific receptor...
  95. ncbi The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkers
    Joaquin Campos
    Department of Internal Medicine, Hospital Clinico Universitario, Fundación Pública Gallega de Medicina Genómica, Santiago de Compostela, Spain
    Alcohol Clin Exp Res 29:1206-13. 2005
    ..We sought too investigate the relationship between the CD14/-159C/T polymorphism and advanced ALD and acute-phase protein levels in heavy drinkers...
  96. ncbi Crystal structure of CD14 and its implications for lipopolysaccharide signaling
    Jung In Kim
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 280:11347-51. 2005
    ..Ligand diversity of CD14 could be explained by the generous size of the pocket, the considerable flexibility of the rim of the pocket, and the multiplicity of grooves available for ligand binding...
  97. ncbi Promoter polymorphism of the gene for CD14 receptor is not associated with sub-clinical carotid atherosclerosis in a community population
    Joseph Hung
    Sir Charles Gairdner Hospital Unit of the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Eur J Cardiovasc Prev Rehabil 11:344-9. 2004
    ..We examined if this polymorphism was associated with sub-clinical carotid atherosclerosis in a community population...
  98. ncbi The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells
    P I Song
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 42:2867-77. 2001
    ..Understanding the function and biology of the corneal LPS receptor complex may lead to novel therapies for the management of ocular Gram-negative bacterial infections...
  99. ncbi Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Liver Int 26:559-65. 2006
    ..The aims of this study were to determine (1) whether hepatic CD14-positive cells are present in various forms of chronic liver disease, and (2) the relationship between CD14-positive cells, myofibroblasts, and fibrosis in these diseases...
  100. ncbi Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes
    Thomas Merlin
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 32:761-72. 2002
    ..Therefore, hyperreactivity to LPS is characterized by an up-regulation of CD14, but the sensitization by P. acnes is not CD14 dependent...
  101. ncbi Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    Crit Care Med 30:969-73. 2002
    ..We evaluated the frequency of a recently discovered CD14 promoter gene polymorphism (C to T transition at base pair -159) among patients with septic shock compared with those in a control group...

Research Grants62

  1. Alveolar macrophage NF-kB signaling in HIV
    Jianmin Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  2. Regulation of TLR4 Signaling in Enterocytes in Necrotizing Enterocolitis
    Amin Afrazi; Fiscal Year: 2013
    ..The current proposal seeks to test whether increasing levels of Heat Shock Protein 70 can serve as a novel therapeutic approach for infants with this devastating disorder. ..
  3. MFG-E8 and progression of alcohol-induced tissue injury
    Xiao Di Tan; Fiscal Year: 2012
    ..They could significantly advance our knowledge about the pathogenesis of alcoholic liver disease. ..
  4. INNATE/ADAPTIVE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM
    MUYIWA EMMANUEL AWONIYI; Fiscal Year: 2010
    ..Our studies seek to provide new insights into the immune mechanisms that protect against NTS, identify differences that contribute to greater vulnerability, and suggest strategies by which to overcome this vulnerability. ..
  5. TLR4 Mutations: Molecular Mechanisms of Impaired LPS Sensitivity
    Andrei E Medvedev; Fiscal Year: 2010
    ..Our research will identify earliest disturbances in functions of receptor and signaling molecules that are caused by TLR4 mutations, and may aid to development of new pharmaceutical drugs to correct such deficiencies. ..
  6. Role of CD14 and other innate immune receptors in severe sepsis
    Sanna M Goyert; Fiscal Year: 2012
    ..The neutrophil is an important cell that serves as a first line of defense against invading bacteria. This proposal aims to identify the molecules and mechanisms that regulate neutrophil recruitment to the site of infection. ..
  7. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2009
    ..abstract_text> ..
  8. Microglial Signaling Mechanisms in Alzheimer's Disease
    Gary E Landreth; Fiscal Year: 2010
    ..We propose to definitively test whether oxidative damage observed in an animal model of AD is due to NADPH oxidase action by examination of animals in which the oxidase has been genetically inactivated. ..
  9. CR3 IN CELL ACTIVATION AND PHAGOCYTOSIS OF GONORRHEA
    ROBIN INGALLS; Fiscal Year: 2001
    ..Finally, we will use somatic cell mutagenesis techniques to generate phagocytosis mutants in the CR3- transfected CHO line. Complementation analysis can then be used to identify genes essential for phagocytosis in human monocytes. ..
  10. RELATIONSHIPS BETWEEN PROSTANOIDS AND CELLULAR INJURY
    John Flynn; Fiscal Year: 2000
    ....
  11. MECHANISMS FOR KERATINOCYTE LIPOPOLYSACCHARIDE RESPONSES
    Christopher Reardon; Fiscal Year: 2002
    ..We will attempt to show with gel-shift assays. Western blots and quantitative RT-PCR that these signaling agents play an important role in LPS-induced activation of keratinocytes. ..
  12. ROLE OF THE CD14 LPS RECEPTOR IN CORNEAL INFLAMMATION
    JOHN ANSEL; Fiscal Year: 2004
    ..Understanding the role of CD14 in mediating corneal innate immunity may result in novel approaches to the management of corneal infectious diseases. ..
  13. IMMUNOCHEMISTRY OF ENDOTOXIN UNRESPONSIVE C3H/HEJ MICE
    David Morrison; Fiscal Year: 1999
    ....
  14. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2007
    ..abstract_text> ..
  15. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2002
    ..abstract_text> ..
  16. MODULATION MOLECULAR PATHOGENESIS IN SYSTEMIC DISEASES
    Caroline Genco; Fiscal Year: 2004
    ..This study will use novel approaches to increase our understanding of the molecular mechanisms of host parasite interactions and the modulation of these processes in systemic diseases. ..
  17. Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Morality
    Stefano Guerra; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. The Role of Lumican in the cornea
    Shukti Chakravarti; Fiscal Year: 2007
    ..abstract_text> ..
  19. TOLL-LIKE RECEPTOR REGULATION IN THE MYOCARDIUM
    Marita Thompson; Fiscal Year: 2004
    ..Cardiac function will be evaluated. Langedorff preparation, histology and animal health/survival following LPS, and LTA administration. ..
  20. Epithelial Barrier During Corneal Infection
    Fu Shin Yu; Fiscal Year: 2004
    ....
  21. MOLECULAR BASIS OF CELL ACTIVATION IN SEPTIC SHOCK
    Jiing Dwan Lee; Fiscal Year: 1999
    ....
  22. ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITY
    Matthew Fenton; Fiscal Year: 2000
    ..abstract_text> ..
  23. LPS signaling and Lung Innate Immunity
    ZHIXING PAN; Fiscal Year: 2004
    ..We propose to determine whether mutations in the TLR4 can account for some of differences in LPS-stimulated signaling linked to activation of NF- B. ..
  24. The Role of TLR4 in Environmental Asthma
    John Sundy; Fiscal Year: 2005
    ..Both the mentor and the institution are highly committed to Dr. Sundy's career development and academic success. ..
  25. LPS-INDUCED NEUTROPHIL ACCUMULATION IN THE LUNG
    G Worthen; Fiscal Year: 2007
    ..1 Description, ..
  26. Vasoprotective Actions of Autologous Cell Transfer
    Robert Simari; Fiscal Year: 2007
    ..Specific Aim 4: To optimize systemic transgene expression from genetically modified EOCs and to determine their systemic vasoprotective potential. [unreadable] [unreadable]..
  27. Host-Pathogen Interactions in Cystic Fibrosis
    SAMUEL MOSKOWITZ; Fiscal Year: 2005
    ..Identifying innate immune genes as modifiers of the CF lung phenotype may suggest new avenues for treating the inflammatory consequences of CF airway infection. ..
  28. LPS-INDUCED SIGNALING IN MACROPHAGES
    Anthony DeFranco; Fiscal Year: 1999
    ..Finally, in this aim, the role of the signaling component Vav in LPS responses will be assessed by studying LPS responses in macrophages from Vav-deficient mice. ..
  29. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  30. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  31. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
    ..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
  32. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
  33. LIVER RESPONSE TO LPS--ROLE OF LBP AND CD14
    Grace Su; Fiscal Year: 2003
    ..II. Determine the mechanism by which LBP and CD14 accelerate ingestion of Gram-negative bacteria. III. Determine the mechanisms by which LBP/CD14 mediated KC activation promote bacterial killing. ..
  34. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    ..abstract_text> ..
  35. Interaction of Chalmydia with Innate Immune Receptors
    ROBIN INGALLS; Fiscal Year: 2009
    ..abstract_text> ..
  36. Minimal Levels of HIV-1 in Vaccinated & Exposed Persons
    Tuofu Zhu; Fiscal Year: 2007
    ..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..
  37. New Model for NeuroAIDS Utilizing Monocyte-Derived HIV-1
    Tuofu Zhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  39. Role of CD14+ Monocytes in HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2005
    ..Findings from this proposal will provide better understanding of productive infection of HIV-1 in CD 14+ monocytes in vivo, and may also provide great insights to developing new therapeutic strategies to enhance therapy efficacy. ..
  40. Effect of DC-SIGNR Polymorphisms on HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2003
    ..These studies should assist in the identification of new therapeutic targets and strategies to protect against HIV-1 transmission and control disease progression. ..
  41. CHROMOSOME 5Q GENE VARIANTS AND ASTHMA-RELATED TRAITS
    Fernando Martinez; Fiscal Year: 2004
    ..This will allow to better understand the genetic influence that determine asthma risk. ..
  42. INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASE
    Fernando Martinez; Fiscal Year: 2003
    ..abstract_text> ..
  43. Heat Shock Proteins and Helicobacter Pylori Pathogenesis
    Evelyn Kurt Jones; Fiscal Year: 2006
    ..Specifically, we will use in vitro and in vivo approaches to investigate the role of heat shock proteins in H. pylori infection and pathogenesis and development of tumors. ..
  44. THE CLINICAL EFFECTIVENESS OF PHARMACY ADHERENCE INFORMATION FOR DIABETES CONTROL
    Keoki Williams; Fiscal Year: 2010
    ..Analyses will control for cluster randomization effects. The introduction of sustainable medication adherence monitoring in clinical practice holds great potential to improve health outcomes among patients with diabetes. ..
  45. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2010
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  46. Neurotoxicity of Chronic Exposure to Air Pollution
    Lilian Calderon Garciduenas; Fiscal Year: 2006
    ..abstract_text> ..
  47. Antibacterial peptidoglycan recognition proteins
    Roman Dziarski; Fiscal Year: 2007
    ..abstract_text> ..
  48. GENETIC REGULATION OF IMMUNE MATURATION IN ASTHMA
    Fernando Martinez; Fiscal Year: 2001
    ....
  49. Mechanism of Endotoxin's Effect On Allergy Risk
    Keoki Williams; Fiscal Year: 2008
    ..It is the hoped that understanding the mechanism of endotoxin's effect will establish new targets for the prevention of allergies. ..
  50. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  51. IL8 and GATA3-mediated Pathways in Asthma Exacerbations
    Fernando Martinez; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable]..
  52. CARE Network - Tucson Clinical Center
    Fernando Martinez; Fiscal Year: 2008
    ..abstract_text> ..
  53. USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCE
    Keoki Williams; Fiscal Year: 2008
    ..abstract_text> ..
  54. Air Pollution and Central Nervous System Disease
    Lilian Calderon Garciduenas; Fiscal Year: 2008
    ..The Award will give me the opportunity to build new skills in 4 areas: Molecular Biology, DNA Damage, Developmental / Neurodegenerative Neuropathology, and to gain experience in grantsmanship. [unreadable] [unreadable]..
  55. IMMUNOBIOLOGY OF HIV-1 INFECTION IN MUCOSA
    Phillip Smith; Fiscal Year: 2007
    ..3) Determine whether intestinal (lamina propria)lymphocytes participate in the selection of the genotypic minor variant that characterizes the transmitted virus in acutely infected recipients. ..
  56. P. aeruginosa as a surrogate marker of cystic fibrosis
    Samuel Miller; Fiscal Year: 2006
    ..Furthermore, the knowledge obtained from this proposal may direct the development of new therapeutic interventions for CF patients. ..
  57. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael D Roth; Fiscal Year: 2010
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
  58. Oxidant Stress: Is it a biomarker of disease progression and response to therapy
    Jesse Roman; Fiscal Year: 2010
    ..End of Abstract) ..
  59. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2010
    ..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..
  60. CD14 Signaling and Activation of Innate Immune Response
    Robert Finberg; Fiscal Year: 2003
    ..These studies will help to define how host invasion by microbes leads to septic shock and may provide novel targets for the design of therapeutic interventions against the life-threatening conditions associated with bacterial sepsis. ..