Genomes and Genes
Summary: Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
Publications234 found, 100 shown here
- The CD14+ CD16+ blood monocytes: their role in infection and inflammationLoems Ziegler-Heitbrock
Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
J Leukoc Biol 81:584-92. 2007..The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease...
- CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteinS D Wright
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
Science 249:1431-3. 1990..Thus, LPS may induce responses by interacting with a soluble binding protein in serum that then binds the cell surface protein CD14...
- Human CD14 mediates recognition and phagocytosis of apoptotic cellsA Devitt
Department of Immunology, University of Birmingham Medical School, UK
Nature 392:505-9. 1998..These results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with 'non-self' components (LPS) and 'self' components (apoptotic cells) produce distinct macrophage responses...
- Peripheral blood CD14high CD16+ monocytes are main producers of IL-10J Skrzeczynska-Moncznik
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland
Scand J Immunol 67:152-9. 2008..In conclusion, our data show that human peripheral blood CD16(+) MO are heterogeneous in function and consist of two subpopulations: CD14(dim) CD16(+) pro-inflammatory and CD14(high) CD16(+) with anti-inflammatory potential...
- Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2J da Silva Correia
Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
J Biol Chem 276:21129-35. 2001..These data support the contention that LPS is in close proximity to the three known proteins of its membrane receptor complex. Thus, LPS binds directly to each of the members of the tripartite LPS receptor complex...
- Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient miceA Haziot
Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
Immunity 4:407-14. 1996..Surprisingly, CD14-deficient mice also showed dramatically reduced levels of bacteremia, suggesting an unexpected role for CD14 in the dissemination of Gram-negative bacteria...
- Unresponsiveness of MyD88-deficient mice to endotoxinT Kawai
Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
Immunity 11:115-22. 1999....
- Tlr4: central component of the sole mammalian LPS sensorB Beutler
Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
Curr Opin Immunol 12:20-6. 2000..The structurally related protein Tlr2 makes no contribution to LPS signal transduction...
- Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparationsT Muta
Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Eur J Biochem 268:4580-9. 2001..Supporting its functional significance, both receptors are found to associate with CD14...
- A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balanceTanja D de Gruijl
Department of Medical Oncology, Division of Immunotherapy, VU University Medical Center, Amsterdam, The Netherlands
J Immunol 176:7232-42. 2006....
- Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adultsAinsley M Sutherland
University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
Crit Care Med 33:638-44. 2005....
- Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteinsHan Jae Shin
Department of Biochemistry, Chungnam National University, Daejeon 305 764, Korea
Mol Cells 24:119-24. 2007..28 10 2 S 1, revealing slow association and fast dissociation with an affinity constant KD of 2.33 x 10-6 M at 25 degreesC. These affinities are consistent with the current view that CD14 conveys LPS to the TLR4/MD-2 complex...
- CD14 signalling in lipid rafts: new ligands and co-receptorsGerd Schmitz
Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
Curr Opin Lipidol 13:513-21. 2002..The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis...
- Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppressionAndreas Sing
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
J Exp Med 196:1017-24. 2002..We conclude that yersiniae might exploit host innate pattern recognition molecules and defense mechanisms to evade the host immune response...
- Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohortC Sengler
Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
Clin Exp Allergy 33:166-9. 2003..Recently, a functional CD14 promoter polymorphism was related to total and specific IgE responsiveness...
- Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2A O Aliprantis
Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Science 285:736-9. 1999..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms...
- Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14M O Labeta
Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XX, United Kingdom
J Exp Med 191:1807-12. 2000....
- Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signalingRaina N Fichorova
Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:2424-32. 2002..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...
- Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral loadLynn Pulliam
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
J Neuroimmunol 157:93-8. 2004..We concluded that there is a circulating CD14+ macrophage hybrid phenotype in subjects with HVL...
- Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cellsF Geissmann
Service d Anatomie Pathologique, Hopital Necker Enfants Malades, Paris, France
J Exp Med 187:961-6. 1998..e., the monocyte, in response to a TGF-beta1-rich microenvironment, as found in the skin and epithelia. Therefore, the monocyte may represent a circulating precursor critical to the immune response in vivo...
- Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signallingR B Yang
Department of Molecular Biology, Genentech, South San Francisco, California 94080 4990, USA
Nature 395:284-8. 1998..Our results indicate that TLR2 is a direct mediator of signalling by LPS...
- Evaluation of CD14 in host defenceP Antal-Szalmas
Utrecht University, The Netherlands, and University Medical School of Debrecen, Hungary
Eur J Clin Invest 30:167-79. 2000....
- Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteinsR L Kitchens
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Clin Invest 108:485-93. 2001..In human plasma, sCD14 thus diminishes monocyte responses to LPS by transferring cell-bound LPS to lipoproteins. Stress-related increases in plasma sCD14 levels may help prevent inflammatory responses within the blood...
- CD14 is an acute-phase proteinSylvette Bas
Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Immunol 172:4470-9. 2004..Liver levels of CD14 mRNA increased in IL-6(+/+), but not in IL-6(-/-) mice. These results indicate that sCD14 can be considered as a type 2 APP...
- The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNFKai Uwe Belge
Institute for Immunology, University of Muenchen, Germany
J Immunol 168:3536-42. 2002..This indicates that the minor population of CD14(+)CD16(+) monocytes are major producers of TNF in human blood...
- Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progressionAntoinette C van der Kuyl
Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 2:e257. 2007..CD169 is highly expressed by macrophages present in AIDS-related Kaposi's sarcoma lesions. It is also increased on blood monocytes of HIV-1 infected patients with a high viral load despite antiretroviral treatment...
- CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserineA Devitt
MRC Center for Inflammation Research, University of Edinburgh, UK
Cell Death Differ 10:371-82. 2003..The additional features that enable apoptotic-cell clearance are derived from mechanisms that can be divorced temporally from those responsible for the morphological features of apoptosis...
- MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptorJean da Silva Correia
Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
J Biol Chem 277:1845-54. 2002....
- TLR4 as the mammalian endotoxin sensorB Beutler
Department of Immunology, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Curr Top Microbiol Immunol 270:109-20. 2002..The fact that LPS signals are elicited through a single biochemical pathway has raised important pharmacotherapeutic opportunities as well...
- Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infectionDouglas D Bannerman
Bovine Functional Genomics Laboratory, USDA Agricultural Research Service ANRI, BARC East, Bldg 1040, Room 2, Beltsville, MD 20705 2350, USA
Clin Diagn Lab Immunol 11:463-72. 2004..coli and S. aureus and suggest that the limited cytokine response to S. aureus may contribute to the well-known ability of the bacterium to establish chronic intramammary infection...
- Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injurySamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
Infect Immun 73:1754-63. 2005....
- Endotoxin recognition molecules, Toll-like receptor 4-MD-2Kensuke Miyake
Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
Semin Immunol 16:11-6. 2004..MD-2 has a role in cell surface expression of TLR4 and interaction with LPS. TLR4-MD-2 contributes to containment of infections by Gram-negative bacteria by activating immune responses...
- Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsisKristine Marie Jessen
Clinical Research Unit, Hvidovre University Hospital, Copenhagen, Denmark
BMC Infect Dis 7:108. 2007..Only few studies have combined the analysis of multiple SNPs in the same population...
- Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding proteinJ D Lee
Department of Immunology, Scripps Research Institute, La Jolla, California 92037
J Exp Med 175:1697-705. 1992..These data provide evidence to support the concept that the LPS receptor in cells that constitutively express CD14 may be a multiprotein complex containing CD14 and membrane protein(s) common to a diverse group of LPS-responsive cells...
- Interaction of polymorphisms in the CARD15 and CD14 genes in patients with Crohn diseaseW Klein
Abteilung für Humangenetik, Ruhr Universitat, Bochum, Germany
Scand J Gastroenterol 38:834-6. 2003..These variations are neither necessary nor sufficient for the genetic predisposition of CD. Further genetic and environmental factors play a crucial role in the pathogenesis of CD...
- The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptorsS M Goyert
Department of Rheumatic Diseases, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003
Science 239:497-500. 1988..In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias...
- CD14 is a cell-activating receptor for bacterial peptidoglycanD Gupta
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
J Biol Chem 271:23310-6. 1996....
- LPS induction of gene expression in human monocytesM Guha
Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Signal 13:85-94. 2001..These signaling pathways in turn activate a variety of transcription factors that include NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun), which coordinate the induction of many genes encoding inflammatory mediators...
- Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cellsYong Han Paik
Department of Medicine, University of North Carolina at Chapel Hill, USA
Hepatology 37:1043-55. 2003..In conclusion, human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF-kappaB and JNK and up-regulate chemokines and adhesion molecules. Thus, HSCs are a potential mediator of LPS-induced liver injury...
- Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infectionS Auffermann-Gretzinger
Divisions of Oncology and of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305-5151, USA
Blood 97:3171-6. 2001..Blood. 2001;97:3171-3176)..
- CD14 is required for MyD88-independent LPS signalingZhengfan Jiang
Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
Nat Immunol 6:565-70. 2005..Thus, the TLR4-MD-2 complex receptor can function in two separate modes: one in which full signaling occurs and one limited to MyD88-dependent signaling...
- CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)V A Fadok
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 161:6250-7. 1998..A maximum of 70% inhibition was achieved by combining anti-CD36 with either anti-a(v) or PS liposomes...
- Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14B Neumeister
Abteilung Transfusionsmedizin der Universität Tübingen, AG Infektionsimmunologie, D 72076 Tubingen, Germany
Infect Immun 66:4151-7. 1998..Our results suggest that the low endotoxic potential of LPS-Lp is due to a failure of interaction with the LPS receptor CD14...
- The presence of functional mannose receptor on macrophages at the maternal-fetal interfaceG Laskarin
Department of Physiology and Immunology, School of Medicine, University of Rijeka, B Branchetta 20 1, 51000 Rijeka, Croatia
Hum Reprod 20:1057-66. 2005..The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling...
- Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tractPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 72:5799-806. 2004..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
- Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14Sachiko Akashi
Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan
J Exp Med 198:1035-42. 2003..These results reveal direct LPS interaction with cell surface TLR4-MD-2 that is distinct from that with MD-2 or CD14...
- Reduced early alcohol-induced liver injury in CD14-deficient miceM Yin
Department of Pharmacology, Laboratory of Hepatobiology and Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 166:4737-42. 2001..Thus, chronic ethanol feeding caused more severe liver injury in wild-type than CD14 knockouts, supporting the hypothesis that endotoxin acting via CD14 plays a major role in the development of early alcohol-induced liver injury...
- CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxolP Y Perera
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 158:4422-9. 1997....
- Dendritic cells in the human deciduaLucy Gardner
Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
Biol Reprod 69:1438-46. 2003..They were also visible in endothelial-lined spaces. This is the first study to identify and describe the phenotype and distribution of human decidual DCs...
- CD14-dependent airway neutrophil response to inhaled LPS: role of atopyN Alexis
Center for Environmental Medicine and Lung Biology, Department of Pediatrics, University of North Carolina-Chapel Hill, 27599-7310, USA
J Allergy Clin Immunol 107:31-5. 2001..CONCLUSION: Constitutive airway CD14 expression can predict the magnitude of the PMN response after inhaled LPS. Atopy appears to play a role in the level of CD14 expression and may contribute to LPS sensitivity in asthmatic subjects...
- Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infectionR S Jack
Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat Greifswald, Germany
Nature 389:742-5. 1997....
- Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involvedNicolas W J Schröder
Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
J Biol Chem 278:15587-94. 2003..However, the involvement of TLR-4 and MD-2 in this process was ruled out...
- Phenotypic characterization of human decidual macrophagesJ Heikkinen
Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
Clin Exp Immunol 131:498-505. 2003..Furthermore, decidual macrophages were not able to differentiate into dendritic cells under the influence of IL-4 + GM-CSF. These results suggest an immunoinhibitory function of decidual macrophages at the maternal-fetal interface...
- A polymorphism in the promoter of the CD14 gene (CD14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki diseaseShinji Nishimura
Department of Pediatrics, Faculty of Medicine, Saga Medical School, and the Division of Pediatrics, Saga Prefectural Hospital Koseikan, Saga, Japan
J Pediatr 143:357-62. 2003..To investigate whether a polymorphism in the CD14 gene is associated with Kawasaki disease (KD)...
- CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery diseaseWolfgang Koenig
Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
J Am Coll Cardiol 40:34-42. 2002..We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation...
- The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureusDaisuke Iwaki
Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
J Biol Chem 277:24315-20. 2002..In addition, we found that sCD14 interacted with sTLR2 and increased the binding of sTLR2 to iPGN. From these results, we conclude that the extracellular TLR2 domain directly binds to PGN...
- The CD14 functional gene polymorphism -260 C>T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathologySander Ouburg
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
BMC Infect Dis 5:114. 2005..We investigated the role of the CD14 -260 C>T polymorphism in the susceptibility to and severity (defined as subfertility and/or tubal pathology) of C. trachomatis infection in Dutch Caucasian women...
- Secretory leukocyte protease inhibitor interferes with uptake of lipopolysaccharide by macrophagesA Ding
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
Infect Immun 67:4485-9. 1999..These results suggest that the inhibitory effect of SLPI on macrophage responses to LPS may, in part, be due to its blockade of LPS transfer to soluble CD14 and its interference with uptake of LPS from LPS-sCD14 complexes by macrophages...
- Phenotypic and functional characteristics of circulating monocytes of elderly personsH M Sadeghi
Center for Interdisciplinary Research in Immunology and Disease and the Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90024 1747, USA
Exp Gerontol 34:959-70. 1999..Such age-related alterations in monocytes may contribute to impaired immune competence of aging...
- CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infectionHakim Echchannaoui
Department of Research, University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
J Leukoc Biol 78:705-15. 2005..In conclusion, CD14 plays a protective role in pneumococcal meningitis by slowing PMN migration via MIP-2 and CXCR2 modulation...
- Legionella pneumophila mediated activation of dendritic cells involves CD14 and TLR2Sibylla Braedel-Ruoff
Interfakultäres Institut für Zellbiologie der Universität Tübingen, Abteilung Immunologie, Tubingen, Germany
J Endotoxin Res 11:89-96. 2005..Our data show that not only purified LPS from L. pneumophila but also the microorganism itself stimulate BMDCs via TLR2 and that this stimulation is dependent on CD14 in this mouse model...
- Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemiaS Liu
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Infect Immun 66:5089-98. 1998..Our observations also support the idea that soluble CD14 is an acute-phase protein and that hepatocytes could be a source for soluble CD14 production...
- Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytesS Liu
Department of Surgery, University of Pittsburgh School of Medicine, PA 15261, USA
Gene 250:137-47. 2000..These data provide novel insights into the regulation of basal CD14 expression in liver cells...
- A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activityT D LeVan
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
J Immunol 167:5838-44. 2001..Variation in a key gene of innate immunity may be important for the pathogenesis of allergy and inflammatory disease through gene-by-gene and/or gene-by-environment interactions...
- Modulatory effects of sCD14 and LBP on LPS-host cell interactionsRichard L Kitchens
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Endotoxin Res 11:225-9. 2005....
- CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytesR A Schlegel
Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania 16802, USA
Cell Death Differ 6:583-92. 1999....
- Dermal-resident CD14+ cells differentiate into Langerhans cellsA T Larregina
Department of Dermatology and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 USA
Nat Immunol 2:1151-8. 2001..Identification and characterization of these LC precursors provided insight into LC biology and the mechanism(s) through which LCs repopulate the epidermis...
- Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitisK M Lammers
Department Internal Medicine and Gastroenterology, Policlinic S Orsola, University of Bologna, Nuove patologie Pad 5, Via Massarenti 9, 40138 Bologna, Italy
World J Gastroenterol 11:7323-9. 2005..To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity...
- Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1D Gupta
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
J Biol Chem 274:14012-20. 1999..This is the first study to demonstrate activation of CREB/ATF and AP-1 transcription factors by PGN or by any other component of Gram-positive bacteria...
- Expression and function of Toll-like receptor 4 in the endometrial cells of the uterusShan Herath
Royal Veterinary College, Department of Veterinary Clinical Sciences, University of London, North Mymms, Hatfield, Hertfordshire AL9 7TA, United Kingdom
Endocrinology 147:562-70. 2006..In conclusion, epithelial and stromal cells detect and respond to bacteria, which modulate their endocrine function...
- CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complexTakashi Nakata
Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Nishi 7, Kita 13, Kita ku, Sapporo 060 8586, Japan
Cell Microbiol 8:1899-909. 2006..7 microM. This study suggests that CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the TLR2/TLR1 complex without binding to the receptor complex...
- Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3Torsten Stein
Division of Cancer Sciences and Molecular Pathology, Western Infirmary, Glasgow, UK
Breast Cancer Res 6:R75-91. 2004..Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process...
- Involvement of microbial components and toll-like receptors 2 and 4 in cytokine responses to air pollution particlesSusanne Becker
U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA
Am J Respir Cell Mol Biol 27:611-8. 2002..In contrast, E5531 had no effect on the response to Staphylococcus. Taken together, these results implicate microbial components as important players in AM-dependent inflammatory responses to PM...
- Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infectionsDoreen M Agnese
Division of Surgical Sciences, Department of Surgery, University of Medicine and Dentistry New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
J Infect Dis 186:1522-5. 2002..These findings indicate that hTLR4 mutations are associated with an increased incidence of gram-negative infections in critically ill patients in a surgical setting...
- The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivoPhilip J Ellery
AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
J Immunol 178:6581-9. 2007..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART...
- Distinct responses of human monocyte subsets to Aspergillus fumigatus conidiaNatalya V Serbina
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 183:2678-87. 2009..Our study demonstrates that functional CD14(+)CD16(-) and CD14(+)CD16(+) monocytes can be isolated from allogeneic hematopoietic stem cell transplantation donors and that these subsets differ in their response to A. fumigatus conidia...
- Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transductionEicke Latz
University of Massachusetts Medical School, Division of Infectious Diseases, Worcester 01605, USA
J Biol Chem 277:47834-43. 2002..Golgi-associated TLR4 expression was disrupted by brefeldin A, yet LPS signaling was preserved. We conclude that LPS signaling may be initiated by surface aggregation of TLR4 and is not dependent upon LPS trafficking to the Golgi...
- Differential chemokine receptor expression and function in human monocyte subpopulationsC Weber
Institute for Prevention of Cardiovascular Disease, Ludwig Maximilians University, Munchen, Germany
J Leukoc Biol 67:699-704. 2000..The characteristics of CD14+CD16+ cells may reflect preactivation by cytokines and determine their predilective localization during specific inflammatory conditions or susceptibility to infection...
- alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitroIzabela M Nita
Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, Lund University, SE 20502 Malmo, Sweden
Int J Biochem Cell Biol 39:1165-76. 2007..These findings provide evidence that AAT is an important regulator of CD14 expression and release in monocytes and suggest that AAT may be involved in LPS neutralization and prevention of over-activation of monocytes in vivo...
- Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathwaysMihai G Netea
Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
Eur J Immunol 32:1188-95. 2002..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
- Divergent response to LPS and bacteria in CD14-deficient murine macrophagesK J Moore
Lipid Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Immunol 165:4272-80. 2000..coli. These data indicate that CD14 is essential for macrophage responses to free LPS, whereas other receptors, including CD11b/CD18, can compensate for the loss of CD14 in response to whole bacteria...
- Essential role of MD-2 in LPS responsiveness and TLR4 distributionYoshinori Nagai
Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Nat Immunol 3:667-72. 2002..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
- CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniaeMark C Dessing
Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Am J Respir Crit Care Med 175:604-11. 2007..Knowledge of the contribution of CD14 to host defense against gram-positive infections is limited...
- Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4A E Medvedev
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 167:2257-67. 2001..Thus, tolerance to LPS and mycobacterial components cannot be attributed solely to a decrease in TLR/MD-2 expression levels, suggesting inhibition of expression or function of other signaling intermediates...
- CD14 is an essential mediator of LPS-induced airway diseaseDavid M Brass
National Institute of Environmental Health Sciences, Rall Bldg, Rm C224, PO Box 12233 MD C2 15, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
Am J Physiol Lung Cell Mol Physiol 293:L77-83. 2007....
- The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lungCatharina W Wieland
Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 175:6042-9. 2005..These data suggest that the MyD88-dependent pathway of TLR4 is important for an effective innate immune response to respiratory tract infection caused by NTHi...
- Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanismC Werts
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Immunol 2:346-52. 2001..These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2...
- Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BCHolger Heine
Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
Eur J Biochem 270:440-50. 2003..Like other LPS, the chlamydial LPS used toll-like receptor TLR4 for signalling, but unlike other LPS activation was strictly CD14-dependent...
- Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infectionC Meiler
Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
World J Gastroenterol 11:6031-7. 2005..Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD) and chronic hepatitis C virus (HCV) infection...
- MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytesNorihiko Sakai
Department of Gastroenterology and Nephrology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
J Leukoc Biol 79:555-63. 2006..These data suggest that fibrogenic processes in Mo regulated by MCP-1/CCR2 may be novel, therapeutic targets for combating organ fibrosis...
- CD14 promoter polymorphism -159C>T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytesJ Rupp
Institute of Medical Microbiology and Hygiene, University of Luebeck, Germany
Genes Immun 5:435-8. 2004..Susceptibility for chronic chlamydial infection of PBMC in CAD patients appears associated with the CD14-159C>T promoter polymorphism encoding for enhanced CD14 expression...
- Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumoniaSylvia Knapp
Laboratory of Experimental Internal Medicine Academic Medical Center, University of Amsterdam, Meibergdreef 9, G2 132, 1105 AZ Amsterdam, The Netherlands
Am J Respir Crit Care Med 173:122-9. 2006..baumannii infection have not been elucidated...
- Correlation between human immunodeficiency virus type 1 RNA levels in the female genital tract and immune activation associated with ulceration of the cervixS D Lawn
Tuberculosis and Mycobacteriology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 181:1950-6. 2000..We suggest that local immune activation increases HIV-1 load in genital secretions, potentially increasing the risk of HIV-1 transmission...
- Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complexSophie C Gangloff
North Shore LIJ Research Institute New York University School of Medicine, Manhasset, NY 11030, USA
J Immunol 175:3940-5. 2005..Thus, CD14(+/+), but not CD14(-/-), macrophages are highly sensitive to stimulation by natural forms of LPS and show the ability to distinguish between various LPS ligands, consistent with CD14 being a highly specific receptor...
- The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkersJoaquin Campos
Department of Internal Medicine, Hospital Clinico Universitario, Fundación Pública Gallega de Medicina Genómica, Santiago de Compostela, Spain
Alcohol Clin Exp Res 29:1206-13. 2005..We sought too investigate the relationship between the CD14/-159C/T polymorphism and advanced ALD and acute-phase protein levels in heavy drinkers...
- Crystal structure of CD14 and its implications for lipopolysaccharide signalingJung In Kim
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 280:11347-51. 2005..Ligand diversity of CD14 could be explained by the generous size of the pocket, the considerable flexibility of the rim of the pocket, and the multiplicity of grooves available for ligand binding...
- Promoter polymorphism of the gene for CD14 receptor is not associated with sub-clinical carotid atherosclerosis in a community populationJoseph Hung
Sir Charles Gairdner Hospital Unit of the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
Eur J Cardiovasc Prev Rehabil 11:344-9. 2004..We examined if this polymorphism was associated with sub-clinical carotid atherosclerosis in a community population...
- The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cellsP I Song
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Invest Ophthalmol Vis Sci 42:2867-77. 2001..Understanding the function and biology of the corneal LPS receptor complex may lead to novel therapies for the management of ocular Gram-negative bacterial infections...
- Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitisKatherine L Leicester
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Liver Int 26:559-65. 2006..The aims of this study were to determine (1) whether hepatic CD14-positive cells are present in various forms of chronic liver disease, and (2) the relationship between CD14-positive cells, myofibroblasts, and fibrosis in these diseases...
- Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnesThomas Merlin
Max Planck Institute for Immunobiology, Freiburg, Germany
Eur J Immunol 32:761-72. 2002..Therefore, hyperreactivity to LPS is characterized by an up-regulation of CD14, but the sensitization by P. acnes is not CD14 dependent...
- Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rateSebastien Gibot
Service de Reanimation Medicale, Hopital Central, Nancy, France
Crit Care Med 30:969-73. 2002..We evaluated the frequency of a recently discovered CD14 promoter gene polymorphism (C to T transition at base pair -159) among patients with septic shock compared with those in a control group...
- Alveolar macrophage NF-kB signaling in HIVJianmin Zhang; Fiscal Year: 2004..abstract_text> ..
- Regulation of TLR4 Signaling in Enterocytes in Necrotizing EnterocolitisAmin Afrazi; Fiscal Year: 2013..The current proposal seeks to test whether increasing levels of Heat Shock Protein 70 can serve as a novel therapeutic approach for infants with this devastating disorder. ..
- MFG-E8 and progression of alcohol-induced tissue injuryXiao Di Tan; Fiscal Year: 2012..They could significantly advance our knowledge about the pathogenesis of alcoholic liver disease. ..
- INNATE/ADAPTIVE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUMMUYIWA EMMANUEL AWONIYI; Fiscal Year: 2010..Our studies seek to provide new insights into the immune mechanisms that protect against NTS, identify differences that contribute to greater vulnerability, and suggest strategies by which to overcome this vulnerability. ..
- TLR4 Mutations: Molecular Mechanisms of Impaired LPS SensitivityAndrei E Medvedev; Fiscal Year: 2010..Our research will identify earliest disturbances in functions of receptor and signaling molecules that are caused by TLR4 mutations, and may aid to development of new pharmaceutical drugs to correct such deficiencies. ..
- Role of CD14 and other innate immune receptors in severe sepsisSanna M Goyert; Fiscal Year: 2012..The neutrophil is an important cell that serves as a first line of defense against invading bacteria. This proposal aims to identify the molecules and mechanisms that regulate neutrophil recruitment to the site of infection. ..
- GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERSNelson Fausto; Fiscal Year: 2009..abstract_text> ..
- Microglial Signaling Mechanisms in Alzheimer's DiseaseGary E Landreth; Fiscal Year: 2010..We propose to definitively test whether oxidative damage observed in an animal model of AD is due to NADPH oxidase action by examination of animals in which the oxidase has been genetically inactivated. ..
- CR3 IN CELL ACTIVATION AND PHAGOCYTOSIS OF GONORRHEAROBIN INGALLS; Fiscal Year: 2001..Finally, we will use somatic cell mutagenesis techniques to generate phagocytosis mutants in the CR3- transfected CHO line. Complementation analysis can then be used to identify genes essential for phagocytosis in human monocytes. ..
- RELATIONSHIPS BETWEEN PROSTANOIDS AND CELLULAR INJURYJohn Flynn; Fiscal Year: 2000....
- MECHANISMS FOR KERATINOCYTE LIPOPOLYSACCHARIDE RESPONSESChristopher Reardon; Fiscal Year: 2002..We will attempt to show with gel-shift assays. Western blots and quantitative RT-PCR that these signaling agents play an important role in LPS-induced activation of keratinocytes. ..
- ROLE OF THE CD14 LPS RECEPTOR IN CORNEAL INFLAMMATIONJOHN ANSEL; Fiscal Year: 2004..Understanding the role of CD14 in mediating corneal innate immunity may result in novel approaches to the management of corneal infectious diseases. ..
- IMMUNOCHEMISTRY OF ENDOTOXIN UNRESPONSIVE C3H/HEJ MICEDavid Morrison; Fiscal Year: 1999....
- INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLSRobert Munford; Fiscal Year: 2007..abstract_text> ..
- CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASESanna Goyert; Fiscal Year: 2002..abstract_text> ..
- MODULATION MOLECULAR PATHOGENESIS IN SYSTEMIC DISEASESCaroline Genco; Fiscal Year: 2004..This study will use novel approaches to increase our understanding of the molecular mechanisms of host parasite interactions and the modulation of these processes in systemic diseases. ..
- Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and MoralityStefano Guerra; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- The Role of Lumican in the corneaShukti Chakravarti; Fiscal Year: 2007..abstract_text> ..
- TOLL-LIKE RECEPTOR REGULATION IN THE MYOCARDIUMMarita Thompson; Fiscal Year: 2004..Cardiac function will be evaluated. Langedorff preparation, histology and animal health/survival following LPS, and LTA administration. ..
- Epithelial Barrier During Corneal InfectionFu Shin Yu; Fiscal Year: 2004....
- MOLECULAR BASIS OF CELL ACTIVATION IN SEPTIC SHOCKJiing Dwan Lee; Fiscal Year: 1999....
- ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITYMatthew Fenton; Fiscal Year: 2000..abstract_text> ..
- LPS signaling and Lung Innate ImmunityZHIXING PAN; Fiscal Year: 2004..We propose to determine whether mutations in the TLR4 can account for some of differences in LPS-stimulated signaling linked to activation of NF- B. ..
- The Role of TLR4 in Environmental AsthmaJohn Sundy; Fiscal Year: 2005..Both the mentor and the institution are highly committed to Dr. Sundy's career development and academic success. ..
- LPS-INDUCED NEUTROPHIL ACCUMULATION IN THE LUNGG Worthen; Fiscal Year: 2007..1 Description, ..
- Vasoprotective Actions of Autologous Cell TransferRobert Simari; Fiscal Year: 2007..Specific Aim 4: To optimize systemic transgene expression from genetically modified EOCs and to determine their systemic vasoprotective potential. [unreadable] [unreadable]..
- Host-Pathogen Interactions in Cystic FibrosisSAMUEL MOSKOWITZ; Fiscal Year: 2005..Identifying innate immune genes as modifiers of the CF lung phenotype may suggest new avenues for treating the inflammatory consequences of CF airway infection. ..
- LPS-INDUCED SIGNALING IN MACROPHAGESAnthony DeFranco; Fiscal Year: 1999..Finally, in this aim, the role of the signaling component Vav in LPS responses will be assessed by studying LPS responses in macrophages from Vav-deficient mice. ..
- Mutagenic analysis of LPS responsesBruce Beutler; Fiscal Year: 2006..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
- Forward Genetic Analysis of the Innate Immune Contribution to MCMV ResistanceBruce Beutler; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Genes that Mediate Tolerance to the Placental AllograftBruce Beutler; Fiscal Year: 2006..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
- TLR4 as an LPS sendor and susceptibility locusBruce Beutler; Fiscal Year: 2007..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
- LIVER RESPONSE TO LPS--ROLE OF LBP AND CD14Grace Su; Fiscal Year: 2003..II. Determine the mechanism by which LBP and CD14 accelerate ingestion of Gram-negative bacteria. III. Determine the mechanisms by which LBP/CD14 mediated KC activation promote bacterial killing. ..
- Innate Immune Receptors in Host Responses to NeisseriaROBIN INGALLS; Fiscal Year: 2009..abstract_text> ..
- Interaction of Chalmydia with Innate Immune ReceptorsROBIN INGALLS; Fiscal Year: 2009..abstract_text> ..
- Minimal Levels of HIV-1 in Vaccinated & Exposed PersonsTuofu Zhu; Fiscal Year: 2007..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..
- New Model for NeuroAIDS Utilizing Monocyte-Derived HIV-1Tuofu Zhu; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Cellular Signaling Mechanisms in Macrophage Activation.Joseph Cuschieri; Fiscal Year: 2007..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
- Role of CD14+ Monocytes in HIV-1 InfectionTuofu Zhu; Fiscal Year: 2005..Findings from this proposal will provide better understanding of productive infection of HIV-1 in CD 14+ monocytes in vivo, and may also provide great insights to developing new therapeutic strategies to enhance therapy efficacy. ..
- Effect of DC-SIGNR Polymorphisms on HIV-1 InfectionTuofu Zhu; Fiscal Year: 2003..These studies should assist in the identification of new therapeutic targets and strategies to protect against HIV-1 transmission and control disease progression. ..
- CHROMOSOME 5Q GENE VARIANTS AND ASTHMA-RELATED TRAITSFernando Martinez; Fiscal Year: 2004..This will allow to better understand the genetic influence that determine asthma risk. ..
- INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASEFernando Martinez; Fiscal Year: 2003..abstract_text> ..
- Heat Shock Proteins and Helicobacter Pylori PathogenesisEvelyn Kurt Jones; Fiscal Year: 2006..Specifically, we will use in vitro and in vivo approaches to investigate the role of heat shock proteins in H. pylori infection and pathogenesis and development of tumors. ..
- THE CLINICAL EFFECTIVENESS OF PHARMACY ADHERENCE INFORMATION FOR DIABETES CONTROLKeoki Williams; Fiscal Year: 2010..Analyses will control for cluster randomization effects. The introduction of sustainable medication adherence monitoring in clinical practice holds great potential to improve health outcomes among patients with diabetes. ..
- Early Forms of Oxidized LDL, TLRs and AtherosclerosisYury Miller; Fiscal Year: 2010..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
- Neurotoxicity of Chronic Exposure to Air PollutionLilian Calderon Garciduenas; Fiscal Year: 2006..abstract_text> ..
- Antibacterial peptidoglycan recognition proteinsRoman Dziarski; Fiscal Year: 2007..abstract_text> ..
- GENETIC REGULATION OF IMMUNE MATURATION IN ASTHMAFernando Martinez; Fiscal Year: 2001....
- Mechanism of Endotoxin's Effect On Allergy RiskKeoki Williams; Fiscal Year: 2008..It is the hoped that understanding the mechanism of endotoxin's effect will establish new targets for the prevention of allergies. ..
- Role of Inter-alpha Inhibitors in Anthrax IntoxicationSteven Opal; Fiscal Year: 2007..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
- IL8 and GATA3-mediated Pathways in Asthma ExacerbationsFernando Martinez; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable]..
- CARE Network - Tucson Clinical CenterFernando Martinez; Fiscal Year: 2008..abstract_text> ..
- USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCEKeoki Williams; Fiscal Year: 2008..abstract_text> ..
- Air Pollution and Central Nervous System DiseaseLilian Calderon Garciduenas; Fiscal Year: 2008..The Award will give me the opportunity to build new skills in 4 areas: Molecular Biology, DNA Damage, Developmental / Neurodegenerative Neuropathology, and to gain experience in grantsmanship. [unreadable] [unreadable]..
- IMMUNOBIOLOGY OF HIV-1 INFECTION IN MUCOSAPhillip Smith; Fiscal Year: 2007..3) Determine whether intestinal (lamina propria)lymphocytes participate in the selection of the genotypic minor variant that characterizes the transmitted virus in acutely infected recipients. ..
- P. aeruginosa as a surrogate marker of cystic fibrosisSamuel Miller; Fiscal Year: 2006..Furthermore, the knowledge obtained from this proposal may direct the development of new therapeutic interventions for CF patients. ..
- Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral ImmunityMichael D Roth; Fiscal Year: 2010..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
- Oxidant Stress: Is it a biomarker of disease progression and response to therapyJesse Roman; Fiscal Year: 2010..End of Abstract) ..
- Systemic Endothelial Consequences of Periodontal DiseaseSalomon Amar; Fiscal Year: 2010..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..
- CD14 Signaling and Activation of Innate Immune ResponseRobert Finberg; Fiscal Year: 2003..These studies will help to define how host invasion by microbes leads to septic shock and may provide novel targets for the design of therapeutic interventions against the life-threatening conditions associated with bacterial sepsis. ..