cd13 antigens

Summary

Summary: Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.

Top Publications

  1. ncbi Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    R Pasqualini
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 60:722-7. 2000
  2. ncbi Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV
    B Delmas
    Unite de Virologie et Immunologie Moleculaires, INRA, Jouy en Josas, France
    Nature 357:417-20. 1992
  3. pmc Location of the Bombyx mori aminopeptidase N type 1 binding site on Bacillus thuringiensis Cry1Aa toxin
    Shogo Atsumi
    Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184 8588, Japan
    Appl Environ Microbiol 71:3966-77. 2005
  4. ncbi Clinical significance of aminopeptidase N in non-small cell lung cancer
    Takahiro Tokuhara
    Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Clin Cancer Res 12:3971-8. 2006
  5. pmc Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I
    D B Tresnan
    Department of Microbiology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Virol 70:8669-74. 1996
  6. ncbi Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma
    Naoya Ikeda
    The Fifth Department of Oncology and the Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka 530 8480, Japan
    Clin Cancer Res 9:1503-8. 2003
  7. ncbi Human aminopeptidase N is a receptor for human coronavirus 229E
    C L Yeager
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799
    Nature 357:420-2. 1992
  8. ncbi CD13--not just a marker in leukemia typing
    D Riemann
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Germany
    Immunol Today 20:83-8. 1999
  9. ncbi Domain III exchanges of Bacillus thuringiensis CryIA toxins affect binding to different gypsy moth midgut receptors
    M K Lee
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Biochem Biophys Res Commun 216:306-12. 1995
  10. ncbi CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells
    Yu Wen Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Int J Cancer 116:243-52. 2005

Research Grants

Detail Information

Publications207 found, 100 shown here

  1. ncbi Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    R Pasqualini
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 60:722-7. 2000
    ..Thus, APN is involved in angiogenesis and can serve as a target for delivering drugs into tumors and for inhibiting angiogenesis...
  2. ncbi Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV
    B Delmas
    Unite de Virologie et Immunologie Moleculaires, INRA, Jouy en Josas, France
    Nature 357:417-20. 1992
    ..First, virions bound specifically to aminopeptidase N that was purified to homogeneity. Second, recombinant expression of aminopeptidase N conferred infectivity by TGEV to an otherwise non-permissive cell line...
  3. pmc Location of the Bombyx mori aminopeptidase N type 1 binding site on Bacillus thuringiensis Cry1Aa toxin
    Shogo Atsumi
    Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184 8588, Japan
    Appl Environ Microbiol 71:3966-77. 2005
    ..We also discuss another area on Cry1Aa toxin as a new candidate site for BmAPN1 binding...
  4. ncbi Clinical significance of aminopeptidase N in non-small cell lung cancer
    Takahiro Tokuhara
    Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Clin Cancer Res 12:3971-8. 2006
    ..APN/CD13 degrades the extracellular matrix, while it is also involved in cell motility and improves angiogenesis...
  5. pmc Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I
    D B Tresnan
    Department of Microbiology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Virol 70:8669-74. 1996
    ..Therefore, host factors in addition to receptor specificity apparently affect the virulence and transmissibility of nonfeline serogroup I coronaviruses in the cat...
  6. ncbi Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma
    Naoya Ikeda
    The Fifth Department of Oncology and the Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka 530 8480, Japan
    Clin Cancer Res 9:1503-8. 2003
    ..In this study, we investigated the expression of APN/CD13 and the intratumor microvessel density (IMD) as the number of microvessel counts in 50 patients with pancreatic carcinoma...
  7. ncbi Human aminopeptidase N is a receptor for human coronavirus 229E
    C L Yeager
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799
    Nature 357:420-2. 1992
    ....
  8. ncbi CD13--not just a marker in leukemia typing
    D Riemann
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Germany
    Immunol Today 20:83-8. 1999
    ..Here, using aminopeptidase N/CD13 as an example, Dagmar Riemann and colleagues discuss the role of cell-cell contact in peptidase regulation and the influence of peptidases on cellular functions...
  9. ncbi Domain III exchanges of Bacillus thuringiensis CryIA toxins affect binding to different gypsy moth midgut receptors
    M K Lee
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Biochem Biophys Res Commun 216:306-12. 1995
    ..This is the first direct evidence that domain III is involved in receptor binding and the first to demonstrate that domain III substitutions direct the binding of these toxins to different gypsy moth midgut receptors...
  10. ncbi CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells
    Yu Wen Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Int J Cancer 116:243-52. 2005
    ....
  11. pmc T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides
    S L Larsen
    Department of Experimental Immunology, University of Copenhagen, Denmark
    J Exp Med 184:183-9. 1996
    ..This could be demonstrated both in cell-free systems using purified reagents and in cellular systems. Thus, MHC class II and APN may act in concert to generate the final T cell epitopes...
  12. ncbi Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer
    Hiroki Hashida
    Department V of Oncology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Gastroenterology 122:376-86. 2002
    ..The aims of this study were to investigate the possible involvement of proteins at the cell surface in controlling cell motility and angiogenesis, and to identify the cell surface molecules involved in gastrointestinal tumors...
  13. ncbi Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo
    Mamoru Yamashita
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Int J Cancer 120:2243-50. 2007
    ..APN/CD13 may be a therapeutic target for the treatment of OVCA in combination with chemotherapy...
  14. ncbi Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells
    Flavio Curnis
    Department of Pathology and Molecular Medicine, DIBIT San Raffaele H Scientific Institute, 20132 Milan, Italy
    Cancer Res 62:867-74. 2002
    ..These findings may explain the selectivity and the tumor-homing properties of NGR-drug conjugates and may have important implications in the development of vascular-targeted therapies based on the NGR/CD13 system...
  15. ncbi Cloning and characterization of Manduca sexta and Plutella xylostella midgut aminopeptidase N enzymes related to Bacillus thuringiensis toxin-binding proteins
    P Denolf
    Plant Genetic Systems, Gent, Belgium
    Eur J Biochem 248:748-61. 1997
    ..Treatment of Sf9 cells expressing the P. xylostella apn1 gene with PtdIns-specific phospholipase C demonstrated that P. xylostella Apn1 is attached to the insect cell membrane by a glycosyl-PtdIns anchor...
  16. ncbi Silencing of midgut aminopeptidase N of Spodoptera litura by double-stranded RNA establishes its role as Bacillus thuringiensis toxin receptor
    R Rajagopal
    International Centre for Genetic Engineering and Biotechnology ICGEB, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110 067, India
    J Biol Chem 277:46849-51. 2002
    ..These results directly implicate larval midgut aminopeptidase N as receptor for Bacillus thuringiensis insecticidal proteins...
  17. ncbi Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells
    Martijn J G Wilmer
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Biochem Biophys Res Commun 337:610-4. 2005
    ..In conclusion, elevated oxidized glutathione in cystinotic proximal tubular epithelial cell lines suggests increased oxidative stress, which may contribute to tubular dysfunction in cystinosis...
  18. ncbi CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells
    Nenad Petrovic
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 278:49358-68. 2003
    ..Thus, the phosphorylation of Ets-2 by RAS/MAPK is a prerequisite for CD13/APN endothelial induction and Ets-2 and its targets play essential roles in endothelial cell function...
  19. ncbi Aminopeptidase-N from the Helicoverpa armigera (Hubner) brush border membrane vesicles as a receptor of Bacillus thuringiensis crylac delta-endotoxin
    S S Ingle
    Department of Microbiology and Biotechnology Centre, Faculty of Science, M.S. University of Baroda, India
    Curr Microbiol 43:255-9. 2001
    ..The first 10-amino-acid sequence showed 60-77% similarity with human cysteine-rich secretory protein-1 precursor, inhibin alpha chain precursor. Salmonella flagellar hook protein and yeast carboxypeptidase S...
  20. ncbi Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion
    K Ishii
    Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Int J Cancer 92:49-54. 2001
    ..Thus, highly expressed AP-N in human cancerous prostate probably plays an important role in the invasion and metastasis of prostate cancer cells...
  21. ncbi Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines
    A Kido
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Clin Exp Metastasis 17:857-63. 1999
    ..Cellular migration correlated highly with APN activity (r = 0.79, P < 0.002). These findings suggest that APN contributes to the invasive potential of human osteosarcomas enhanced by IL-6 and SIL-6R...
  22. ncbi cDNA cloning and expression of Bacillus thuringiensis Cry1Aa toxin binding 120 kDa aminopeptidase N from Bombyx mori
    K Yaoi
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 0054, Japan
    Biochim Biophys Acta 1444:131-7. 1999
    ..Subsequently, the recombinant APN was expressed by Escherichia coli and its Cry1Aa toxin binding ability was analyzed. Ligand blotting showed that Cry1Aa toxin bound to the recombinant APN...
  23. ncbi Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells
    Yuji Mishima
    Biochemical Research Laboratory, Morinaga Milk Industry Co Ltd, Kanagawa, Japan
    J Natl Cancer Inst 94:1020-8. 2002
    ..Consequently, we investigated the relationship between cell-surface aminopeptidase activity and endothelial IL-8 induction of apoptosis in various leukemic cell lines...
  24. ncbi Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells
    Akira Kido
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Clin Exp Metastasis 20:585-92. 2003
    ..These findings demonstrate that APN plays an active role in the cellular attachment and proteolytic degradation of the extracellular matrix in the metastatic process of osteosarcomas...
  25. ncbi A mouse aminopeptidase N is a marker for antigen-presenting cells and appears to be co-expressed with major histocompatibility complex class II molecules
    A S Hansen
    Institute of Medical Microbiology and Immunology, Panum Institute, University of Copenhagen, Denmark
    Eur J Immunol 23:2358-64. 1993
    ..The expression of APN showed a striking correlation with the MHC class II expression in all the cell populations studied. This apparent co-expression suggests a role for APN in antigen processing...
  26. ncbi Identification of two isoforms of aminopeptidase N in Aedes aegypti larval midgut
    Kusol Pootanakit
    Institute of Molecular Biology and Genetics, Mahidol University, Salaya Campus, Nakhon Pathom 73170, Thailand
    J Biochem Mol Biol 36:508-13. 2003
    ..Which of the two isoforms (or other yet unidentified receptor proteins) is involved in the killing of mosquito larvae remains to be elucidated...
  27. ncbi Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid
    Takeo Hirano
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
    Leuk Res 26:1097-103. 2002
    ..Thus bestatin, an immunomodulator clinically used for nonlymphocytic leukemia, synergistically increased the ATRA-induced differentiation of NB4 cells by inhibiting CD13/aminopeptidase N on the cell-surface...
  28. ncbi Reduced growth, increased vascular area, and reduced response to cisplatin in CD13-overexpressing human ovarian cancer xenografts
    Yvette van Hensbergen
    Department of Medical Oncology, Vrye Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Clin Cancer Res 10:1180-91. 2004
    ..Thus far, the role of CD13 in ovarian cancer has not been studied. We have investigated the expression pattern and biological function of CD13 in ovarian cancer...
  29. ncbi The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis
    Shripad V Bhagwat
    Departments of Pathology, and Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 101:1818-26. 2003
    ..These studies provide strong evidence that CD13/APN is an important target of Ras signaling in angiogenesis and is a limiting factor in angiogenic progression...
  30. ncbi Increased expression of interleukin-8 and aminopeptidase N by cell-cell contact: interleukin-8 is resistant to degradation by aminopeptidase N/CD13
    A Kehlen
    Martin Luther University, Institute of Medical Immunology, Magdeburger Strasse 2, D-06097 Halle, Germany
    Eur Cytokine Netw 12:316-24. 2001
    ..The much more sensitive HPLC technique resulted in negative results as well...
  31. ncbi Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N
    A F Kolb
    Institute of Virology and Immunology, University of Wurzburg, Germany
    J Gen Virol 78:2795-802. 1997
    ..These changes were sufficient to convert porcine APN into a functional receptor for HCV 229E and thus define a small number of residues that are critically important for the HCV 229E receptor function of human APN...
  32. ncbi Biological significance of aminopeptidase N/CD13 in thyroid carcinomas
    Astrid Kehlen
    Institute of Medical Immunology, University of Halle Wittenberg, Halle, Germany
    Cancer Res 63:8500-6. 2003
    ....
  33. ncbi The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review
    B Miguel
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State 39762, USA
    Arch Virol 147:2047-56. 2002
    ..The hamster cells became permissive to IBV after transfection with a fAPN cDNA suggesting that the feline APN molecule plays a role in IBV entry...
  34. ncbi Expression of aminopeptidase N/CD13 in human ovarian cancers
    P Surowiak
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Int J Gynecol Cancer 16:1783-8. 2006
    ..001). Thus, the data indicate that a potential treatment of ovarian carcinoma with CD13 inhibitors should be performed before chemotherapy or in parallel to first-lapse chemotherapy...
  35. pmc Binding specificity of Bacillus thuringiensis Cry1Aa for purified, native Bombyx mori aminopeptidase N and cadherin-like receptors
    J L Jenkins
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    BMC Biochem 2:12. 2001
    ..Previous studies on B. mori receptors utilized brush border membrane vesicles or purifed receptors in blot-type assays...
  36. ncbi Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix
    Yvette van Hensbergen
    Department of Medical Oncology, Amsterdam, VU University Medical Center, The Netherlands
    Thromb Haemost 90:921-9. 2003
    ..The identification of this novel effect of bestatin is important in the light of the proposed use of bestatin as anti-angiogenic and/or anti-tumor agent...
  37. pmc Interaction of gene-cloned and insect cell-expressed aminopeptidase N of Spodoptera litura with insecticidal crystal protein Cry1C
    Neema Agrawal
    International Center for Genetic Engineering and Biotechnology, New Delhi 110067, India
    Appl Environ Microbiol 68:4583-92. 2002
    ..By these experiments we showed that the bioactive toxin, Cry1C, binds to the recombinant APN, while the nonbioactive toxin, Cry1Ac, showed no interaction...
  38. ncbi Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells
    L H Shapiro
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee
    J Biol Chem 266:11999-2007. 1991
    ..Both aminopeptidase N transcripts encode the same polypeptide, indicating that the physically distinct promoters must have evolved to regulate expression of this cell-surface peptidase by cells of different tissues...
  39. ncbi Molecular cloning of a GPI-anchored aminopeptidase N from Bombyx mori midgut: a putative receptor for Bacillus thuringiensis CryIA toxin
    G Hua
    Department of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Gene 214:177-85. 1998
    ..Taken together, the deduced amino acid sequence suggests that the 110-kDa APN is a GPI-anchored protein and a specific receptor protein for B. thuringiensis CryIA delta-endotoxin...
  40. ncbi Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer
    B Göhring
    Department of Urology, Martin Luther University Halle Wittenberg, Halle, Germany
    Int J Mol Med 2:409-14. 1998
    ..Aminopeptidase N (APN) and aminopeptidase A (APA) show attenuated expression in up to one third of clear cell/ chromophilic RCC. Chromophobe RCC and oncocytomas do not express APN, APA, NEP and gamma-glutamyltranspeptidase...
  41. ncbi Microgranular and t(11;17)/PLZF-RARalpha variants of acute promyelocytic leukemia also present the flow cytometric pattern of CD13, CD34, and CD15 expression characteristic of PML-RARalpha gene rearrangement
    Edgar G Rizzatti
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Am J Hematol 76:44-51. 2004
    ..Thus, the immunophenotypic profile highly characteristic of the PML-RARalpha gene rearrangement was also observed in microgranular and PLZF-RARalpha variants of APL...
  42. ncbi [Study on the immunophenotypes of bone marrow cells from patients with myelodysplastic syndromes and its clinical implications]
    Jian Ying Wang
    Department of Hematology, The Affiliated Hospital of Lu Zhou Medical College, Luzhou 646000, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 10:173-4. 2002
    ..It is suggested that the bone marrow cells from MDS patients showed abnormality of more than two series of immunophenotypes, detection of immunophenotype in MDS cells might be contributed to the diagnosis and predicting prognosis...
  43. ncbi The analogy in cell immunophenotype and parameters of cell cycle of ectopic thymus, normal thymus, and some acute lymphoblastic leukemia of T-phenotype
    O Babusikova
    Cancer Research Institute Slovak Academy of Sciences, Bratislava, 83391 Slovakia
    Neoplasma 49:312-8. 2002
    ....
  44. ncbi Phenotypic heterogeneity of B cells in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
    Bal Kampalath
    Dept of Pathology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Am J Clin Pathol 119:824-32. 2003
    ..001). There is considerable phenotypic heterogeneity in CLL/SLL, and expression of aberrant markers indicates aggressiveness...
  45. ncbi Comparison of effects of angiotensin peptides in the regulation of clitoral cavernosum smooth muscle tone
    J K Park
    Department of Urology, Chonbuk National University Medical School, Keum Am Dong San, Chonju, South Korea
    Int J Impot Res 14:72-80. 2002
    ..It is also suggested that peptides of the ANG family have a cross-talk with the NO system and aminopeptidase is involved in the modulation of the tone of clitoral CSM by ANG III and ANG IV...
  46. ncbi Leukemias resembling acute promyelocytic leukemia, microgranular variant
    Sanjai Nagendra
    Department of Pathology, University of Iowa College of Medicine, Iowa City, USA
    Am J Clin Pathol 117:651-7. 2002
    ..DIC was present in 2 patients with M3v. Our study shows that there are no definitive morphologic, cytochemical, or immunophenotypic findings that can distinguish these cases from PML/RARalpha-positive APL...
  47. ncbi Expression of enkephalin-degrading enzymes in human semen and implications for sperm motility
    Nerea Subiran
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Spain
    Fertil Steril 89:1571-7. 2008
    ..To investigate the presence of two enkephalin-degrading enzymes (aminopeptidase N [APN] and neutral endopeptidase 24.11 [NEP]) in different fractions of human semen, their distribution in sperm cells, and their effect on sperm motility...
  48. ncbi Characterization of renin-angiotensin system enzyme activities in cultured mouse podocytes
    Juan Carlos Q Velez
    Department of Research, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina, USA
    Am J Physiol Renal Physiol 293:F398-407. 2007
    ..These findings may reflect a specific role of POD in maintenance of intraglomerular renin-angiotensin system balance...
  49. ncbi Adult precursor T-lymphoblastic leukemia/lymphoma with myeloid-associated antigen expression is associated with a lower complete remission rate following induction chemotherapy
    Murtadha Al Khabori
    Departments of Laboratory Hematology and Medical Oncology, University Health Network, Toronto, Ont, Canada
    Acta Haematol 120:5-10. 2008
    ..Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy...
  50. ncbi Characteristics of human prostasomes isolated from three different sources
    Lena Carlsson
    Department of Medical Sciences, Clinical Chemistry Unit, University Hospital, Uppsala, Sweden
    Prostate 54:322-30. 2003
    ..Prostasomes are organelles secreted by human prostate epithelial cells and appear freely in semen. Most prostasomal functional and biochemical characteristics have been settled on basis of seminal prostasomes (SP)...
  51. ncbi Flow cytometric technique for determination of prostasomal quantity, size and expression of CD10, CD13, CD26 and CD59 in human seminal plasma
    Lena Carlsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Int J Androl 29:331-8. 2006
    ..Flow cytometry is a practical way to study prostasomes in seminal fluid without prior separation. This is a new technique for evaluation of the role of prostasomes and their functions in male reproductive physiology...
  52. ncbi Distribution of carboxypeptidase M on lymphoid and myeloid cells parallels the other zinc-dependent proteases CD10 and CD13
    B de Saint-Vis
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    Blood 86:1098-105. 1995
    ....
  53. ncbi Novel markers for the prospective isolation of human MSC
    Hans Jorg Buhring
    Department of Internal Medicine II, University Clinic, Medical Research Center, Otfried Müller Str 27, 72076 Tubingen, Germany
    Ann N Y Acad Sci 1106:262-71. 2007
    ..These MSC may be used as an improved starting population for transplantation in diseases like osteogenesis imperfecta, cartilage repair, and myocardial infarction...
  54. ncbi Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML
    Julius M Cruse
    Department of Pathology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Exp Mol Pathol 83:274-6. 2007
    ..e., 13 (81.3%) cases demonstrated normal expression. Therefore, these results point to frequently decreased expression levels of CD10, CD13, and CD15 and rarely decreased expression levels of CD33 in association with CML...
  55. ncbi Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects
    James C Ritchie
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Neuropsychopharmacology 28:22-33. 2003
    ..In cortex membranes, similar peptidase inhibition was without effect. These data support the hypothesis that ectopeptidases play a major role in CRF metabolism and biological function...
  56. ncbi Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects
    Brigitte Bauvois
    Unité INSERM 507, Hopital Necker, Universite Rene Descartes Paris V, Batiment Lavoisier, 161 rue de Sevres, 75015 Paris, France
    Med Res Rev 26:88-130. 2006
    ..Current status on their potential use as therapeutic agents is discussed with regard to toxicity and specificity...
  57. ncbi Pharmacodynamic monitoring of BAY 43-9006 (Sorafenib) in phase I clinical trials involving solid tumor and AML/MDS patients, using flow cytometry to monitor activation of the ERK pathway in peripheral blood cells
    Frances K Tong
    Department of Pathology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cytometry B Clin Cytom 70:107-14. 2006
    ..Cytometry 2001;46:72-78). In this article, we describe its application to phase I trials of BAY 43-9006 in solid tumor and AML/MDS patients...
  58. ncbi Two methods for the quantitative analysis of surface antigen expression in acute myeloid leukemia (AML)
    Jolanta Woźniak
    Department of Physiopathology, Institute of Haematology and Blood Transfusion, Warsaw, Poland
    Folia Histochem Cytobiol 42:195-9. 2004
    ..This may be helpful in identification of leukemic cells in the diagnostics of minimal residual disease after treatment in AML patients...
  59. ncbi Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience
    Claudiu Plesa
    Leukemia Unit, Edouard Herriot Hospital, Lyon Civil Hospices, Lyon, France
    Cancer 112:572-80. 2008
    ..The impact of initial characteristics on prognosis has been addressed previously in elderly patients; however, very few data are available regarding the prognostic value of immunophenotypic characteristics in this setting...
  60. ncbi Characterization of CD34+, CD13+, CD33- cells, a rare subset of immature human hematopoietic cells
    Giuseppe Gaipa
    Centro Ricerca M Tettamanti, Clinica Pediatrica, Universita Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, 20052 Monza MI, Italy
    Haematologica 87:347-56. 2002
    ..We noted the presence of CD34+ cells expressing CD13 but lacking CD33, a subset of cells not yet well characterized. In this report we describe the prevalence and the immunophenotype of this cell subset...
  61. ncbi [Immunologic classification used in typing of 68 cases of acute leukemias]
    Xiu Li Sun
    Department of Hematology, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:39-41. 2006
    ..In conclusion, immunologic classification can improve the accuracy in acute leukemia diagnosis. The diagnosis of some special AL, such as acute unidentified leukemia (AUL), AML-M(0) and so on, must rely on immunologic classification...
  62. pmc Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens
    Tomas Kalina
    Department of Immunology, Charles University 2nd Medical School, Prague, Czech Republic
    BMC Cancer 5:38. 2005
    ....
  63. ncbi Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients
    B Maecker
    Department of Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany
    Leukemia 20:645-9. 2006
    ..Thus, depletion of DC in B-lineage ALL patients may contribute to poor anti-leukemia immune responses...
  64. ncbi Simultaneous expression of CD13, CD22 and CD25 is related to the expression of Fc epsilon R1 in non-lymphoid leukemia
    Naoko Sato
    First Department of Internal Medicine, Niigata University Medical and Dental Hospital, Asahimachi Dori 1, Niigata City 951 8520, Japan
    Leuk Res 28:691-8. 2004
    ..Moreover, CD22 may be one of target molecules for treatment of CD22-positive, poorly prognostic leukemia...
  65. ncbi Bimodal cell populations are common in chronic lymphocytic leukemia but do not impact overall survival
    Amy E Cocco
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Clin Pathol 123:818-25. 2005
    ..Therefore, although bimodal antigen expression is common in CLL, the presence of bimodality does not seem to have significant prognostic importance..
  66. ncbi The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK+ anaplastic large cell lymphomas
    Ian M Bovio
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Clin Pathol 130:628-34. 2008
    ..03). The myeloid-associated antigens CD13 and/or CD33 are sensitive but not entirely specific markers of ALK+ ALCLs and should not be misinterpreted as indicating myeloid sarcoma...
  67. ncbi Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome. An immunophenotypic analysis
    N J Karandikar
    Division of Hematopathology and Immunology, Department of Pathology, University of Texas-Southwestern Medical Center at Dallas, USA
    Am J Clin Pathol 116:204-10. 2001
    ..The immunophenotypic similarities suggest a biologic relationship between the disorders; however, distinct immunophenotypic differences also were observed...
  68. ncbi In vitro chemosensitivity testing of selected myeloid cells in acute myeloid leukemia
    Lars Mollgard
    Department of Hematology, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Leuk Lymphoma 44:783-9. 2003
    ..01). This new method is feasible and makes it possible to selectively evaluate the effect of cytotoxic drugs in myeloid cells. Further studies with a larger group of patients are needed to evaluate the predictive value of the assay...
  69. ncbi Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs
    H Chen
    , INSERM U266, CNRS UMR 8600, Paris Cedex 06, France
    J Med Chem 44:3523-30. 2001
    ..These results account for the long duration of action observed with these prodrugs...
  70. ncbi Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes
    Jean Michel Benoist
    Laboratoire de Physiopharmacologie du Système Nerveux, INSERM U161, 2 rue d Alésia, 75014 Paris Cedex, France
    Eur J Pharmacol 445:201-10. 2002
    ..In addition, the present study revealed an efficacy of these compounds over a wide range of stimulus intensities, albeit excluding the highest...
  71. ncbi The prognostic value of maturation-associated phenotypic abnormalities in myelodysplastic syndromes
    I Lorand-Metze
    Faculty of Medicine, State University of Campinas, Brazil
    Leuk Res 32:211-3. 2008
    ..Therefore, phenotypic features that can also be obtained from PB might be useful for predicting survival in MDS...
  72. ncbi Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia
    Lei Tian
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:364-8. 2005
    ..Therefore, trisomy 8 may be an adverse prognostic factor for patients with M(4) or M(5)...
  73. ncbi The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer
    Stacy Carl-McGrath
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Int J Oncol 25:1223-32. 2004
    ....
  74. ncbi Peptidase activities in rats treated chronically with N(omega)-nitro-L-arginine methyl ester (L-NAME)
    Alessandra Linardi
    Departamento de Farmacologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brazil
    Biochem Pharmacol 68:205-14. 2004
    ..The altered peptidase activities seen in aorta may contribute to modulating vascular responses in this model of hypertension...
  75. ncbi Cloning of the pig aminopeptidase N gene. Identification of possible regulatory elements and the exon distribution in relation to the membrane-spanning region
    J Olsen
    Department of Biochemistry C, Panum Institute, University of Copenhagen, Denmark
    FEBS Lett 251:275-81. 1989
    ..The gene sequence includes the first three exons and two introns. It shows that a single exon encodes the cytoplasmic tail, the membrane anchor and the junctional peptide...
  76. ncbi Expression of aminopeptidase N and dipeptidyl peptidase IV in the healthy and asthmatic bronchus
    V H van der Velden
    Department of Immunology, Erasmus University and University Hospital Dijkzigt, Rotterdam, The Netherlands
    Clin Exp Allergy 28:110-20. 1998
    ..The effects of peptides are modulated by peptidases, which are able to degrade peptides, mostly resulting in their inactivation...
  77. pmc Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma
    C Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Clin Pathol 58:1069-75. 2005
    ....
  78. ncbi CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated
    E J Favaloro
    Department of Haematology, Westmead Hospital, New South Wales, Australia
    Exp Hematol 21:1695-701. 1993
    ..These findings have significant implications for our understanding of the many functions of this molecule in blood...
  79. pmc CD13 (human aminopeptidase N) mediates human cytomegalovirus infection
    C Soderberg
    Department of Clinical Immunology, Novum, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden
    J Virol 67:6576-85. 1993
    ..Thus, human CD13 appears to mediate HCMV infection by a process that increases binding, but its enzymatic domain is not necessary for infection...
  80. ncbi Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent
    A R Jensen
    Department of Animal Science and Animal Health, Division of Animal Nutrition, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg, Denmark
    J Nutr 131:3259-65. 2001
    ..Bovine colostrum mixed with porcine plasma proteins may be a useful substitute for porcine colostrum in artificial rearing of newborn pigs...
  81. ncbi Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats
    John W Wright
    Department of Psychology, Washington State University, Pullman, Washington 99164 4820, USA
    Am J Physiol Regul Integr Comp Physiol 284:R725-33. 2003
    ..These results suggest that the brain AT(1) receptor may be designed to preferentially respond to ANG III, and ANG III's importance as a centrally active ligand has been underestimated...
  82. ncbi The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities
    Jean Stéphane Poumarat
    Laboratoire de Physiologie et Endocrinologie Cellulaire Rénale, Universite Pierre et Marie Curie, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
    Kidney Int 62:434-45. 2002
    ....
  83. ncbi Variable O-glycosylation of CD13 (aminopeptidase N)
    P J O'Connell
    Department of Clinical Immunology, St Vincent s Hospital, Fitzroy, Victoria, Australia
    J Biol Chem 266:4593-7. 1991
    ..Similar observations with the integrin group of molecules suggests that this may be an example of a more general phenomenon among glycoproteins...
  84. ncbi Angiotensinase activities in the kidney of renovascular hypertensive rats
    Isabel Prieto
    Unit of Physiology, University of Jaen, Bldg B 3, 23071 Jaen, Spain
    Peptides 24:755-60. 2003
    ..These results suggest a role for AlaAP in renovascular hypertension. In addition, the higher AspAP activity of the renal cortex compared to medulla reflects its relative functional difference between both locations...
  85. ncbi Effects of alpha1-adrenergic receptor blockade by doxazosin on renin-angiotensin system-regulating aminopeptidase and vasopressin-degrading activities in male and female rat thalamus
    S de la Chica-Rodríguez
    Experimental and Clinical Physiopathology Research Group, Department of Health Sciences, Faculty of Experimental and Health Sciences, University of Jaen, Jaen, Spain
    Horm Metab Res 39:813-7. 2007
    ....
  86. ncbi Effects of changes in hydromineral balance on rat brain aspartyl, arginyl, and alanyl aminopeptidase activities
    A Varona
    Department of Physiology, Faculty of Medicine, University of the Basque Country, Bilbao, Vizcaya, Spain
    Horm Metab Res 35:36-42. 2003
    ..These results indicate that aminopeptidases in the central nervous system may be involved in the physiological regulation of hydromineral balance...
  87. ncbi In vivo administration of doxazosin in rats highly decreases serum circulating levels of testosterone through a mechanism involving the testicular renin-angiotensin system
    S de la Chica-Rodríguez
    Experimental and Clinical Physiopathology Research Group, Department of Health Sciences, Faculty of Experimental and Health Sciences, University of Jaen, Jaen, Spain
    Int J Androl 31:364-70. 2008
    ....
  88. ncbi Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma
    Adolfo Varona
    Dept of Physiology, Faculty of Medicine and Dentistry, Hospital de Basurto, University of the Basque Country, E 48080 Bilbao, Bizkaia, Spain
    Am J Physiol Renal Physiol 292:F780-8. 2007
    ..3-fold). This peptidase activity profile in the neoplastic kidney suggests a specific role for the studied convertases and the possible involvement of an intracrine renin-angiotensin system in the pathogenesis of CCRCC...
  89. ncbi Aminopeptidase activity in the nigrostriatal system and prefrontal cortex of rats with experimental hemiparkinsonism
    I Banegas
    Unit of Physiology, University of Jaen, Building B3, 23071 Jaen, Spain
    Horm Metab Res 37:53-5. 2005
  90. ncbi Subcellular distribution of membrane-bound aminopeptidases in the human and rat brain
    Gorka Larrinaga
    Department of Nursing I, University of the Basque Country, Bilbao, Bizkaia, Spain
    Neurosci Lett 383:136-40. 2005
    ..Moreover, these peptidases may play specific roles depending on their activity levels at the different subcellular structures where they are localized...
  91. ncbi Aminopeptidase activity in the postmortem brain of human heroin addicts
    G Larrinaga
    Department of Nursing I, University of the Basque Country, Leioa, P O Box 699, E 48940 Bilbao, Bizkaia, Spain
    Neurochem Int 46:213-9. 2005
    ..This result agrees with previous findings in morphine-tolerant rats, and indicates that soluble PSA may be involved in neurobiological processes which underlie heroin addiction...
  92. ncbi Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure
    Masafumi Tsujimoto
    Laboratory of Cellular Biochemistry, Saitama, Japan
    Heart Fail Rev 13:285-91. 2008
    ..In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized...
  93. ncbi Induction by cortisol of aminopeptidases production from the human placenta in tissue culture
    Y Yasuda
    Department of Obstetrics and Gynaecology, Nagoya University School of Medicine, Japan
    Horm Metab Res 24:110-4. 1992
    ..From 34.5 nM to 3.45 microM of cortisol significantly increased the activities of 3 enzymes. Our present data suggest a possible important role of cortisol in the growth of human placenta via induction of placental aminopeptidases...
  94. pmc Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12
    H Suzuki
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    J Bacteriol 183:1489-90. 2001
    ..Aminopeptidases A, B, and N and dipeptidase D, with broad substrate specificity, are the four cysteinylglycinases of Escherichia coli K-12, and there is no peptidase specific for the cleavage of cysteinylglycine...
  95. ncbi Synergistic action of DPIV and APN in the regulation of T cell function
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Adv Exp Med Biol 524:123-31. 2003
    ..Therefore, the simultaneous inhibition of these enzymes represents a promising strategy for the pharmacological therapy of T cell mediated diseases such as autoimmune disease, inflammation, allergy, and allograft rejection...
  96. ncbi Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein
    Wanda Nowak
    3o Cátedra de Farmacología, Departamento de Farmacologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 9, CP 1121 Buenos Aires, Argentina
    Naunyn Schmiedebergs Arch Pharmacol 375:221-9. 2007
    ..In conclusion, in the present study for the first time, we demonstrated in a capacitance vessel, HUV, that metallopeptidases ACE, NEP and APM represent a relevant functional inactivation pathway of DAKD...
  97. ncbi Effects of low-flow sevoflurane anesthesia on renal function: comparison with high-flow sevoflurane anesthesia and low-flow isoflurane anesthesia
    H Bito
    Hamamatsu University Hospital and the Department of Anesthesiology and Intensive Care, Japan
    Anesthesiology 86:1231-7. 1997
    ....
  98. pmc Is carbon dioxide a safe and good alternative for diatrizoate meglumine as a contrast in digital subtraction angiography?
    U N Hegde
    Department of Nephrology, Muljibhai Patel Urological Hospital, Nadiad, India
    Indian J Nephrol 19:15-9. 2009
    ..Both iodinated contrast and CO(2) cause significant enzymuria. More severe enzymuria (>50% increase) was seen significantly less with the use of CO(2). Quality of images is better with iodinated contrast...
  99. ncbi Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats
    H Zhan
    Department of Opthalmology, Shiga University of Medical Science, Seta Otsu, Japan
    Histochem J 33:511-21. 2001
    ....
  100. ncbi Differential effects of dietary cholesterol on aminopeptidase A, B and M in the frontal cortex of male and female mice
    M J Ramirez-Exposito
    Unit of Physiology, Faculty of Experimental and Health Sciences, University of Jaen, Spain
    Nutr Neurosci 4:461-8. 2001
    ....
  101. ncbi Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study
    J Gil
    Department of Physiology, Medical School, University of the Basque Country, Leioa, Spain
    Neuropeptides 35:276-84. 2001
    ..The differential distribution of these enzymes could suggest that these activities have different functions in the distinct subcellular structures of the human and the rat brain...

Research Grants21

  1. Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
    Vivian Y H Hook; Fiscal Year: 2013
    ..Results will also yield candidate inhibitors of these aminopeptidases for future investigation of aminopeptidase regulation in Alzheimer's disease. ..
  2. INTESTINAL AMINOOLIGOPEPTIDASE--SYNTHESIS AND ASSEMBLY
    Gary Gray; Fiscal Year: 1990
    ..In this manner, it will be possible to correlate intestinal mRNA levels for AOP with its synthesis rates in vivo and to design further experiments to ascertain the regulation of translation of this important digestive enzyme...
  3. MOLECULAR REGULATION OF INTESTINAL AMINOOLIGOPEPTIDASE
    Mitchell Cohen; Fiscal Year: 1991
    ..The proposed research should provide an in depth understanding of the molecular regulation of this essential brush border enzyme...
  4. MECHANISMS OF ENTEROCYTE CELL SURFACE POLARITY
    Dennis Ahnen; Fiscal Year: 1990
    ..These studies are aimed at answering the basic question of how enterocytes which are morphologically and functionally polar establish and maintain their cell surface polarity...
  5. Identification of Novel Candidate Salt-Sensitivity Genes
    Robert Danziger; Fiscal Year: 2005
    ..This is a first step in the goal of developing novel and customized therapeutic approaches to hypertension based on genetics. ..
  6. Broad Spectrum MDR Modulation in AML
    Maria Baer; Fiscal Year: 2004
    ..The study is expected to provide essential information for the design of future clinical trials of broad-spectrum MDR modulation in AML and other malignancies. ..
  7. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
    ..This study may provide important information on the mechanism of action of a class of angiogenesis inhibitors, information that may prove helpful in designing clinical trials for these compounds. [unreadable] [unreadable]..
  8. STORAGE AND CATABOLISM OF DIETARY AMINO ACIDS IN MICE
    OSCAR SCORNIK; Fiscal Year: 2001
    ....
  9. Molecular Specialization of Tumor Lymphatics
    Erkki Ruoslahti; Fiscal Year: 2008
    ..Promising compounds emerging from these experiments will be tested in pre-clinical cancer models for treatment of cancer and prevention of metastasis. [unreadable] [unreadable]..
  10. SARS Reverse Genetics
    Ralph Baric; Fiscal Year: 2008
    ..The goal of this application is to establish genetic control over the SARS genome and provide uniform reagents that will be used by other groups throughout the country. ..
  11. Regulation of Apoptosis by Integrins
    Erkki Ruoslahti; Fiscal Year: 2007
    ..Cells that become malignant may bypass this pathway in becoming anchorage independent and metastatic. ..
  12. REVERSE GENETICS WITH A CORONAVIRUS INFECTIOUS CONSTRUCT
    Ralph Baric; Fiscal Year: 2004
    ..The assembly of a full-length TGE construct is an important breakthrough for coronavirus research and will benefit all aspects of coronavirus pathogenesis, molecular biology, epidemiology and biochemistry. ..
  13. TISSUE TARGETING WITH PHAGE LIBRARIES
    Erkki Ruoslahti; Fiscal Year: 2001
    ..Major advances in tumor therapies could be realized with this technology. Valuable information on the distinguishing characteristics of different vascular beds, including those undergoing angiogenesis, is also likely to ensue. ..
  14. Remodeling SARS Coronavirus Genome Regulatory Networks
    Ralph Baric; Fiscal Year: 2004
    ..abstract_text> ..
  15. TUMOR CELLS IN CIRCULATION
    Erkki Ruoslahti; Fiscal Year: 2001
    ..Finally, the ability to eliminate tumor cells from the circulation by sFN administration may provide additional protection against tumor cell transfer in bone marrow transplantation used to treat cancer and against tumor metastasis. ..
  16. INTEGRIN REGULATION BY R-RAS
    Erkki Ruoslahti; Fiscal Year: 2002
    ..As the R-ras interactions we have uncovered are novel for the Ras protein superfamily, new information on this important family of cellular regulators and oncoproteins will ensue. ..
  17. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  18. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..
  19. Plant Production and Delivery System for Bacterial Toxins to Mosquity Larvae
    Mohd Amir Abdullah; Fiscal Year: 2008
    ..It should produce significant public health-related benefits through better control of vector-borne disease and substantial commercial opportunities. [unreadable] [unreadable] [unreadable]..