Genomes and Genes
Summary: A CD antigen that contains a conserved I domain which is involved in ligand binding. When combined with CD18 the two subunits form MACROPHAGE-1 ANTIGEN.
Publications208 found, 100 shown here
- Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other lociJohn B Harley
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
Nat Genet 40:204-10. 2008..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
- CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cellsKenji Kabashima
Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
Am J Pathol 171:1249-57. 2007..These findings demonstrated that CXCL12-CXCR4 engagement on cutaneous DCs plays a crucial role in the initiation of skin immune response by enhancing cutaneous DC migration...
- Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasisLi Yang
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cancer Cell 13:23-35. 2008..Together, these data indicate that Gr-1+CD11b+ cells contribute to TGFbeta-mediated metastasis through enhancing tumor cell invasion and metastasis...
- A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysM T Audrey Nguyen
Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 282:35279-92. 2007..Together our results show that FFAs can activate CD11c(+) myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance...
- Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutaseGenevieve Gowing
Laboratory of Molecular Endocrinology, Centre de Recherche du Centre Hospitalier de l Universite Laval, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
J Neurosci 28:10234-44. 2008..This suggests that proliferating microglia-expressing mutant SOD1 are not central contributors of the neurodegenerative process in ALS caused by mutant SOD1...
- Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cellsCorine H GeurtsvanKessel
Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
J Exp Med 205:1621-34. 2008..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
- Stem cell fate specification: role of master regulatory switch transcription factor PU.1 in differential hematopoiesisGurudutta U Gangenahalli
Stem Cell Gene Therapy Research Group, Institute of Nuclear Medicine and Allied Sciences INMAS, DRDO, Delhi 110054, India
Stem Cells Dev 14:140-52. 2005..1 at various stages of hematopoietic development beginning from stem cell proliferation, lineage commitment and terminal differentiation into distinct blood cell types, and leukemogenesis...
- Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cellsFarbod Shojaei
Genentech, Inc, 1 DNA Way, S San Francisco, California 94080, USA
Nat Biotechnol 25:911-20. 2007..These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b+Gr1+ cells...
- CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitisBing Zhu
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 179:5228-37. 2007..Further understanding of suppressive monocytes in autoimmune disease models may have important clinical implications for human autoimmune diseases...
- CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stressValeriya P Makarenkova
Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA
J Immunol 176:2085-94. 2006..Understanding the mechanism of immune suppression by these cells has important clinical implications in the treatment of immune dysfunction after trauma or surgery...
- Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1Can Shi
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 114:408-18. 2004..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...
- The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph nodeMichael Sixt
Department for Experimental Pathology, Lund University, 22185 Lund, Sweden
Immunity 22:19-29. 2005..The conduit system is, therefore, not a closed compartment that shuttles substances through the lymph node but represents the morphological equivalent to the filtering function of the lymph node...
- The terminology issue for myeloid-derived suppressor cellsDmitry I Gabrilovich
Cancer Res 67:425; author reply 426. 2007
- Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjectsNeil E Alexis
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
J Allergy Clin Immunol 112:353-61. 2003..Macrophage and neutrophil functions have been reported to be modified by endotoxin in vitro and in vivo, and response to endotoxin is mediated largely by airway phagocytes and related to allergic inflammation...
- Neutrophil infiltration of culprit lesions in acute coronary syndromesTakahiko Naruko
Department of Cardiology, Osaka City General Hospital, Osaka
Circulation 106:2894-900. 2002..Neutrophils in unstable atherosclerotic lesions have not received much consideration, despite accumulating evidence suggesting a link between systemic inflammation and acute coronary syndromes...
- Fibrinogen-CD11b/CD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophilsCarolina Rubel
Division Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
Eur J Immunol 33:1429-38. 2003..These results shed light on the molecular mechanisms that control human granulocyte apoptosis, and suggest that NF-kappa B regulation may be of benefit for the resolution of the inflammatory response...
- Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humansNeil E Alexis
National Health and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Clin Immunol 111:126-31. 2004..Consequently, CD11b may be a useful biomarker for predicting susceptibility to airway neutrophilic inflammation caused by pollutants...
- Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpGFrancois Xavier Hubert
Institut National de la Sante et de la Recherche Medicale, Unite 437, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 1, France
J Immunol 172:7485-94. 2004..Therefore, rat pDC appear very similar to human pDC, indicating that the specific phenotype and functions of pDC have been highly conserved between species...
- MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsisMatthew J Delano
Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Exp Med 204:1463-74. 2007..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
- Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophagesKazuichi Maruyama
Ocular Immunology Group, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Invest 115:2363-72. 2005..The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis...
- CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral toleranceR William DePaolo
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 171:3560-7. 2003..These data indicate that CCL2 and signaling through its receptor CCR2 is critical for the induction of oral tolerance by regulating Ag presentation leading to a disruption in the balance of inflammatory and regulatory cytokines...
- Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathwayLydia A Haile
Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
Gastroenterology 135:871-81, 881.e1-5. 2008..Here, for the first time, we have identified and analyzed their role in inflammatory bowel disease (IBD)...
- Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic micePing Li
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 50:265-76. 2004..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo...
- Collagen-induced arthritis is exacerbated in IL-10-deficient miceAlison Finnegan
Department of Medicine, Section of Rheumatology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
Arthritis Res Ther 5:R18-24. 2003..Since IL-10 levels are elevated in rheumatoid arthritis synovial fluid, these findings may have relevance to rheumatoid arthritis...
- Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesisBert De Klerck
Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
Arthritis Res Ther 6:R220-31. 2004..They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA...
- A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteinsSun Sang J Sung
Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
J Immunol 176:2161-72. 2006..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
- RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharidesJana Morova
Institute of Microbiology of the Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
Proc Natl Acad Sci U S A 105:5355-60. 2008..These results show that binding and killing of target cells by CyaA, LtxA, and HlyA depends on recognition of N-linked oligosaccharide chains of beta(2) integrin receptors. This sets a new paradigm for action of RTX cytotoxins...
- Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individualsJohn C Lay
J Allergy Clin Immunol 120:719-22. 2007
- Bordetella adenylate cyclase toxin: a swift saboteur of host defenseJana Vojtova
Institute of Microbiology of the Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic
Curr Opin Microbiol 9:69-75. 2006..Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen...
- Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cordMarie Gingras
Laboratoire d Organogénèse EXpérimentale LOEX, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital du Saint Sacrement and Département de chirurgie, Faculte de Medecine, Universite Laval, Quebec, Canada G1S 4L8
J Neurosci Methods 163:111-8. 2007....
- Differential response of respiratory dendritic cell subsets to influenza virus infectionXueli Hao
Carter Immunology Center, UVA, P O Box 801386, Charlottesville, VA 22908, USA
J Virol 82:4908-19. 2008..Our results indicate that RDC are targets of influenza virus infection and that distinct RDC subsets differ in their susceptibilities and responses to infection...
- Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesisLi Yang
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cancer Cell 6:409-21. 2004..Our data provide evidence that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs...
- CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunityMaria P Lemos
Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
J Immunol 171:5077-84. 2003..These findings indicate that DCs are not only key initiators of the primary response, but provide all of the necessary cognate interactions to control CD4(+) T cell fate during the primary immune response...
- Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repairJeremy S Duffield
Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
J Clin Invest 115:56-65. 2005..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
- Multistable and multistep dynamics in neutrophil differentiationHannah H Chang
Vascular Biology Program, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
BMC Cell Biol 7:11. 2006..However, the dynamics of mammalian cell differentiation has not been analyzed with respect to bistability...
- Aggravated Lyme carditis in CD11a-/- and CD11c-/- miceMireia Guerau-de-Arellano
Department of Pathology, Tufts University School of Medicine, Jaharis 512, 150 Harrison Ave, Boston, MA 02111, USA
Infect Immun 73:7637-43. 2005..burgdorferi burden relative to that of WT mice. Overall, our results suggest that the increased severity of Lyme carditis in CD18 hypomorph mice is caused by deficiency in CD11a or CD11c, possibly via different mechanisms...
- Activation of peripheral and in vivo transmigrated neutrophils in patients with stable coronary artery diseaseJosefin Paulsson
Department of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden
Atherosclerosis 192:328-34. 2007....
- Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory responseCord Sunderkotter
Institute of Experimental Dermatology and Department of Dermatology, University of Munster, Munster, Germany
J Immunol 172:4410-7. 2004..Taken together, these data identify distinct subpopulations of mouse blood monocytes that differ in maturation stage and capacity to become recruited to inflammatory sites...
- Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cellsG One Ahn
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive, CCSR South, Room 1255, Stanford, CA 94305, USA
Cancer Cell 13:193-205. 2008..Our results suggest that MMP-9 could be an important target for adjunct therapy to enhance the response of tumors to radiotherapy...
- Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAXGeoffrey Hom
Genentech, South San Francisco, CA 94080, USA
N Engl J Med 358:900-9. 2008..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
- A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosusSwapan K Nath
Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
Nat Genet 40:152-4. 2008..0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development...
- Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive rufflingJana Kamanova
Cellular and Molecular Microbiology Division, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
J Immunol 181:5587-97. 2008....
- Induction of CD69 activation molecule on human neutrophils by GM-CSF, IFN-gamma, and IFN-alphaFabiola Atzeni
Rheumatology Unit, Ospedale L Sacco, University of Milan, Milan, Italy
Cell Immunol 220:20-9. 2002..CD69 cross-linking on GM-CSF-primed neutrophils sinergized with LPS and increased TNF-alpha production and secretion suggesting a role for CD69-positive neutrophils in the pathogenesis and maintenance of different inflammatory diseases...
- Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progressionN van Royen
Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
Circ Res 92:218-25. 2003..However, the local treatment did not preclude systemic effects on atherogenesis, leading to increased atherosclerotic plaque formation and changes in cellular content of plaques...
- CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiationDriss Ehirchiou
Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Exp Med 204:1519-24. 2007..Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation...
- Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populationsClaudia Jakubzick
Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 180:3019-27. 2008..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
- Reactive microgliosis engages distinct responses by microglial subpopulations after minor central nervous system injuryMartin Wirenfeldt
Medical Biotechnology Center, University of Southern Denmark, Odense
J Neurosci Res 82:507-14. 2005..Our results show that distinct subpopulations of microglia respond to minor CNS injury. The heterogeneity in microglial response may have functional consequences for repair and possibly therapy...
- Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophilsJie Liu
Section of Pulmonary and Critical Care Medicine, Department of Medicine MC6076, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Pulm Pharmacol Ther 17:73-9. 2004..IL-5-induced adhesion likely utilizes a different upstream mechanism in regulation of integrin adhesion...
- Cutting Edge: A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytesEiji Esashi
Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
J Immunol 171:2773-7. 2003..Finally, engulfed nuclei were frequently found in CD4(+)/CD11b(+) cells. These results strongly suggest that thymic CD4(+)/CD11b(+) cells are major scavengers of apoptotic thymocytes...
- CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycansKe Zen
Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Immunol 169:5270-8. 2002..These findings implicate epithelial cell surface proteoglycans decorated with sulfated fucose moieties as ligands for CD11b/CD18 during PMN migration across mucosal surfaces...
- Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)H Zhang
The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
Inflamm Res 52:86-93. 2003..The goal of this study is to investigate the consequence of the interaction between Mac-1 and uPAR and determine the mechanisms by which uPAR regulates Mac-1 dependent adhesion to fibrinogen...
- Systemic upregulation of leukocyte integrins in response to lower body ischemia-reperfusion during abdominal aortic aneurysm repairMadeleine Valdes Pahl
Departments of Medicine, University of California Irvine, Irvine, CA, USA
J Natl Med Assoc 97:172-9. 2005..The mean time to peak expression of CD18 in neutrophils and monocytes during reperfusion was 34.0 and 40.0 minutes in venous and 47.5 and 50.0 minutes in arterial blood, respectively...
- CD11b regulates recruitment of alveolar macrophages but not pulmonary dendritic cells after pneumococcal challengeAlun C Kirby
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Infect Dis 193:205-13. 2006..These data demonstrate that there are significant differences between AM and pulDC responses to inflammatory pathogenic stimuli in vivo...
- Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activitiesRadovan Fiser
Department of Genetics and Microbiology, Faculty of Science, Charles University, CZ 128 44, Prague 2
J Biol Chem 282:2808-20. 2007..Hence, the translocating AC polypeptide itself appears to participate in formation of a novel type of membrane path for calcium ions, contributing to action of CyaA in an unexpected manner...
- Migration of polymorphonuclear leucocytes is influenced by dendritic cellsM Lucila Scimone
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Immunology 114:375-85. 2005..Furthermore, our results also suggest that CXCL8 production by immature DCs might be regulated by signalling through CD31 during their migration through the vascular endothelium...
- Transmigration of blood leukocytes into the peritoneal cavity is related to the upregulation of ICAM-1 (CD54) and Mac-1 (CD11b/CD18) adhesion moleculesTomasz Liberek
Department of Nephrology, Transplantology and Internal Medicine, Gdansk Medical University, Gdansk, Poland
Perit Dial Int 24:139-46. 2004..To study the role of adhesion molecules in the process of leukocyte transmigration, we compared the expression of several adhesion receptors between peripheral blood monocytes and macrophages isolated from overnight dwell effluents...
- Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] BChun K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Am J Respir Cell Mol Biol 29:133-47. 2003..These cytokines therefore play a crucial role, via the p38 MAPK and NF-kappaB pathways, in the expression of important adhesion molecules on eosinophils in allergic inflammation...
- A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonistGrant C Nicholson
National Heart and Lung Institute NHLI, Clinical Studies Unit, Imperial College London, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
Pulm Pharmacol Ther 20:52-9. 2007..Cellular activation can also trigger chemotaxis and shape change, the activation itself being caused by the binding of chemokines to cell surface receptors...
- Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytesMarek Basler
Institute of Microbiology CAS, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
Infect Immun 74:2207-14. 2006....
- LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytesKi Hoon Han
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
J Lipid Res 44:1332-40. 2003..In a previous study, we showed that LDL induces the expression of CCR2 in monocytes. We conclude that this may be the underlying cause of the enhanced chemokine effect on CD11b expression and activation observed with these cells...
- A standardized procedure for quantitation of CD11b on polymorphonuclear neutrophil by flow cytometry: potential application in infectious diseasesV Latger-Cannard
Laboratory of Hematology, CHU Nancy, Vandoeuvre les Nancy, France
Clin Lab Haematol 26:177-86. 2004..This method allowed us to evidence an up-regulation of CD11b expression for infected patients. This quantitation is a standardized and potentially useful method in clinical situations implying quantitative CD11b expression variations...
- Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesisLudovic Arnold
Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
J Exp Med 204:1057-69. 2007..In conclusion, injured skeletal muscle recruits MOs exhibiting inflammatory profiles that operate phagocytosis and rapidly convert to antiinflammatory MPs that stimulate myogenesis and fiber growth...
- TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infectionNatalya V Serbina
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Immunity 19:59-70. 2003..Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen...
- Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing miceYasushi Sawanobori
Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Blood 111:5457-66. 2008..Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development...
- Ovarian monocyte progenitor cells: phenotypic and functional characterizationCherry J Pascual
Department of Pediatrics, University of South Florida, St Petersburg, FL 33612, USA
Stem Cells Dev 14:173-80. 2005..We conclude that in the ovaries, a higher requirement for macrophages is provided by a resident stromal population of progenitors whose progeny is restricted to the production of cells of the monocyte-macrophage lineage...
- Interleukin-15 increases neutrophil adhesion onto human respiratory epithelial A549 cells and attracts neutrophils in vivoM Pelletier
INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, PQ H9R 1G6, Canada
Clin Exp Immunol 141:315-25. 2005..IL-15 might participate in inflammatory pulmonary diseases by attracting neutrophils, modulating cell surface expression molecules and increasing neutrophil adhesion onto pulmonary cells...
- Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptorsGeorge Hajishengallis
Center of Excellence in Oral and Craniofacial Biology and Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
J Biol Chem 280:38902-13. 2005..Elucidation of pathogen interactions with PRRs at the molecular level may glean insight into host defense mechanisms as well as into microbial strategies that subvert innate immunity...
- [Effect of cardiopulmonary bypass on CD11/CD18 expression of neutrophils in children undergoing cardiac surgery]Qiang Shu
The Affiliated Children s Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Zhejiang Da Xue Xue Bao Yi Xue Ban 36:66-70. 2007..To investigate the changes in perioperative expression level of CD11/CD18 of neutrophils in children undergoing cardiac surgery with cardiopulmonary bypass (CPB)...
- Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammationDriss El Kebir
Research Center, Maisonneuve Rosemont Hospital, University of Montreal, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
Circ Res 103:352-9. 2008..Our results indicate that MPO functions as a survival signal for neutrophils and thereby contribute to prolongation of inflammation...
- Ovarian cancer cells modulate human blood neutrophils response to activation in vitroM Klink
Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
Scand J Immunol 68:328-36. 2008..Our results suggest the possibility that neutrophils responding to contact with cancer cells contribute to the progression and metastatic potential of tumour cells...
- Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expressionCristina Lecchi
Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Italy
Vet Res 39:50. 2008....
- Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophilsJ J Liu
Laboratory of Molecular Biology, Luzhou Medical College, Sichuan 646000, China
Inflamm Res 54:500-7. 2005....
- CD157 is part of a supramolecular complex with CD11b/CD18 on the human neutrophil cell surfaceL Lavagno
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
J Biol Regul Homeost Agents 21:5-11. 2007..These results confirm that CD157 physically interacts with CD11b/CD18 complex in human neutrophils...
- Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitroM Klink
Centre for Medical Biology, Polish Academy of Sciences, 93 232, Lodz, Lodowa 106, Poland
Inflamm Res 56:282-90. 2007..We investigated the intracellular signalling pathways by which nitric oxide (NO) donors: diethylamine/NO (DEA/NO) and 3-morpholinosydnonimine (SIN-1) regulate the functional response of human neutrophils to activating stimuli...
- Platelet activation, upregulation of CD11b/ CD18 expression on leukocytes and increase in circulating leukocyte-platelet aggregates in Indian women chronically exposed to biomass smokeM R Ray
Experimental Hematology Unit, Chittaranjan National Cancer Institute, Kolkata 700 026, India
Hum Exp Toxicol 25:627-35. 2006..The results show that chronic biomass smoke exposure activates circulating platelets, PMN and monocytes, and increases the number of leukocyte-platelet aggregates, which are considered a risk factor for thrombosis...
- Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on LPS-induced mesenteric microcirculatory disturbance in ratsJun Guo
Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China
Shock 29:205-11. 2008..Treatment with DLA or SAB significantly ameliorated LPS-induced microcirculatory disturbance in rat mesentery and inhibited both the expression of CD11b and CD18 and the production of *O2- and H2O2 by neutrophils caused by LPS...
- Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitorsYuka Sugimoto
Department of Haematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan
Br J Haematol 135:725-31. 2006..Our data may also offer one explanation for the rapid recovery of monocytes in comparison with neutrophils in the early phase of haematopoietic regeneration...
- Src family kinases mediate neutrophil adhesion to adherent plateletsVirgilio Evangelista
Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
Blood 109:2461-9. 2007..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...
- TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriaeEvlambia Harokopakis
Center for Oral Health and Systemic Disease, University of Louisville Health Sciences Center, KY 40292, USA
J Immunol 176:7645-56. 2006..Thus, P. gingivalis fimbriae activate a novel proadhesive pathway in human monocytes, involving TLR2, Rac1, PI3K, and CD11b/CD18, which may constitute a mechanistic basis linking P. gingivalis to inflammatory atherosclerotic processes...
- Polymorphonuclear leukocyte integrins in chronic renal failureGregorio Caimi
Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universita di Palermo, Palermo, Italy
Clin Hemorheol Microcirc 32:43-9. 2005..The altered behaviour of the PMN integrin pattern in mild CRF patients, likely reflecting a state of PMN activation, might have a pathophysiological significance, considering the high incidence of cardiovascular events in CRF...
- Induction of polymorphonuclear leukocyte response by human cytomegalovirusPetra Jerström Skarman
Department of Medicine, Center for Molecular Medicine, L8 03, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
Microbes Infect 8:1592-601. 2006..Instead, the fact that apoptosis is inhibited may cause over-reactive neutrophils to remain in the tissues, where they will start leaking their contents, damaging the tissues and contributing to inflammatory processes...
- Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganismsHitoshi Nakayama
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2 1 1 Tomioka, Urayasu, Chiba 279 0021, Japan
J Leukoc Biol 83:728-41. 2008..Taken together, these observations suggest that CD11b activation causes translocation of CD11b/CD18 into Lyn-coupled, LacCer-enriched lipid rafts, allowing neutrophils to phagocytose NOZs via CD11b/CD18...
- Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra)Evlambia Harokopakis
Department of Pedodontics, School of Dentistry, Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
J Periodontol 77:271-9. 2006....
- Alterations of CD43 expression in transfusion-dependent myelodysplastic syndromesE Kyriakou
Department of Hematology, University Hospital of Thessalia, Larissa, Greece
Ann Hematol 85:281-4. 2006..Given together, these results show that decreased CD43 in the transfused group of MDS patients is associated with an activated endothelial phenotype...
- ICAM-1 and CD11b/CD18 expression during acute pancreatitis induced by bile-pancreatic duct obstruction: effect of N-acetylcysteineLaura Ramudo
Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
Exp Biol Med (Maywood) 232:737-43. 2007....
- Inhibitory effects of catechins on neutrophil-dependent gastric inflammationOsamu Handa
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachidori Hirokouji Agaru, Kyoto, Japan
Redox Rep 7:324-8. 2002..These results suggest that tea may inhibit carcinogenesis partly through the anti-inflammatory effects of tea catechins on PMN-dependent gastric mucosal inflammation...
- Leptin indirectly activates human neutrophils via induction of TNF-alphaHamid Zarkesh-Esfahani
Division of Clinical Sciences North, University of Sheffield, Sheffield, United Kingdom
J Immunol 172:1809-14. 2004..In conclusion, although leptin activates PMN, it does so indirectly via TNF-alpha release from monocytes. These findings provide an additional link among the obesity-derived hormone leptin, innate immune function, and infectious disease...
- Stimulation of neutrophil apoptosis by immobilized IgAJorge Schettini
Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, and Laboratory of Immunogenetics, Department of Microbiology, Buenos Aires University School of Medicine, Argentina
J Leukoc Biol 72:685-91. 2002..Stimulation of neutrophil apoptosis by IgA might contribute to the control of inflammatory processes in certain autoimmune diseases such as IgA nephropathy in which tissue deposits of IgA or IgA containing immune complexes are found...
- Evaluation of leukocyte cell surface markers in dogs with septic and nonseptic inflammatory diseasesDouglas J Weiss
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
Am J Vet Res 65:59-63. 2004..To determine whether functional alterations in neutrophils and mononuclear leukocytes are a consistent finding in dogs with inflammatory disease...
- Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroidsP Ballabh
Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
Arch Dis Child Fetal Neonatal Ed 89:F76-83. 2004....
- The effect of (1-->3)-beta-D-glucans, carboxymethylglucan and schizophyllan on human leukocytes in vitroLukas Kubala
Institute of Biophysics Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
Carbohydr Res 338:2835-40. 2003..The higher potency of SPG to stimulate human blood phagocytes in vitro could be caused by factors such as higher branching frequencies or neutral polymer charge of SPG or different conformation in solution if compared with CMG...
- Social stress alters splenocyte phenotype and functionRonit Avitsur
Section of Oral Biology, The Ohio State University Health Sciences Center, Columbus, OH, USA
J Neuroimmunol 132:66-71. 2002..Together, these findings indicate that social stress altered phenotype and function of splenic immune cells. These findings may have implications for the healing of bite wounds that are often associated with social stress in rodents...
- Function of the lectin domain of Mac-1/complement receptor type 3 (CD11b/CD18) in regulating neutrophil adhesionYu Xia
Chemoattractant Group of the James Graham Brown Cancer Center, Department of Pathology, University of Louisville, KY 40202, USA
J Immunol 169:6417-26. 2002..These data indicate that the same lectin domain within CD11b regulates both the cytotoxic and adhesion functions of Mac-1/CR3...
- Circadian variation in cell-adhesion molecule expression by normal human leukocytesGary D Niehaus
Department of Physiology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Box 95, Rootstown, OH 44272, USA
Can J Physiol Pharmacol 80:935-40. 2002....
- Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in miceDori L Borjesson
Center for Comparative Medicine, Schools of Medicine Veterinary Medicine, University of California, Davis 95616, USA
Blood 101:3257-64. 2003..Establishment of feeding pools that rely less on leukocyte trafficking and more on small hemorrhages may explain the ready amplification of A phagocytophila DNA from ticks infested on CD11/CD18-deficient mouse strains...
- Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosisJenny Jongstra-Bilen
Cell Biology Program, Hospital for Sick Children and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1X8, Canada
J Biol Chem 278:45720-9. 2003..FcgammaR can enhance host defense by activating Mac-1 (and possibly other integrins), having a synergistic effect on pathogen engulfment and promoting the adherence of phagocytes at sites of infection...
- Glutamine improves impaired cellular exudation and polymorphonuclear neutrophil phagocytosis induced by total parenteral nutrition after glycogen-induced murine peritonitisShigeo Ikeda
Department of Surgery, The University of Wisconsin, Madison, Wisconsin 53792, USA
Shock 19:50-4. 2003..06). There were no significant differences in ROI production or CD11b and CD16/32 expression on peritoneal PMN. GLN supplementation improved the reduction in cell exudation and PMN phagocytosis induced by TPN after chemical peritonitis...
- L-selectin and beta2-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitisA Diez-Fraile
Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
J Dairy Sci 86:2334-42. 2003..The knowledge of adhesion molecule kinetics in relation to the different parameters evaluated in the present study contributes to an improved understanding of the inflammatory reaction...
- Expression of beta2-integrin on monocytes and blood polymorphonuclear leukocytes in the periparturient period in dairy cowsAraceli Diez-Fraile
Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Can J Vet Res 67:235-8. 2003..In this study, the decreased number of milk resident macrophages and PMN observed during the periparturient period could not be attributed to changes of CD11/CD18 levels on circulating leukocytes...
- Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivoPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, Oxford, GB
Eur J Immunol 33:2090-7. 2003....
- The strength of integrin binding between neutrophils and endothelial cellsV Labrador
Cell and Tissue Mechanics and Engineering, LEMTA UMR CNRS 7563, Faculty of Medicine, 54505 Vandoeuvre les Nancy, France
Eur Biophys J 32:684-8. 2003..Analysis of the flow dependence of the number of attached cells reveals the prevailing number of neutrophils with stronger binding to the endothelium when both cells are in the activated state in comparison with non-activated cells...
- Recruitment of Murine Mast Cell ProgenitorsJUAN ABONIA; Fiscal Year: 2007..The aim of this proposal is to identify those pathways which are responsible for inflammatory recruitment of MCp to the lung and intestine. ..
- CELL SURFACE ANTIGENS ON HUMAN MACROPHAGESRobert Todd; Fiscal Year: 1999..It is the goal of this investigation to test the hypothesis that cooperative interactions among neutrophil receptors govern the neutrophil response to certain external stimuli and contribute to host immunity. ..
- Experimental Uveal Melanoma and Ocular Immune PrivilegeKYLE MCKENNA; Fiscal Year: 2007..abstract_text> ..
- Prevention of UV-carcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2004..abstract_text> ..
- Proanthocyanidins: Novel Skin Cancer Preventive AgentSantosh Katiyar; Fiscal Year: 2006..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
- Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ CellsMichael Bailey; Fiscal Year: 2008..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
- Prevention of skin cancer by green tea polyphenolsSantosh Katiyar; Fiscal Year: 2009..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
- Prevention of Photocarcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2003..abstract_text> ..
- The Role of KLF6 Tumor Suppressor in Hepatocellular CancerSCOTT LAURENCE FRIEDMAN; Fiscal Year: 2010..abstract_text> ..
- Oligodendrocyte Progenitors in Spinal Cord Injury RepairDANA MCTIGUE; Fiscal Year: 2006..abstract_text> ..
- Behavior of Stem Cells in the Lesioned Aging HippocampusAshok Shetty; Fiscal Year: 2006..abstract_text> ..
- Repair of Chronially Injured Hippocampus by GraftsAshok Shetty; Fiscal Year: 2006..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
- Pericytes in Pathogenesis of Germinal-Matrix HemorrhagePraveen Ballabh; Fiscal Year: 2006..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
- Hypertonic Modulation of Inflammation following InjuryEileen M Bulger; Fiscal Year: 2010..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
- Role of CIC-3 channels in regulation of cell volume and shape in neutrophilsJessica Moreland; Fiscal Year: 2007..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
- Insulin producing cells generated in vitro from hepatic stem cellsLijun Yang; Fiscal Year: 2007..abstract_text> ..
- The Insulitis Reporter MouseJonathan Katz; Fiscal Year: 2007..Specific Aim 2: To validate the specificity and sensitivity of the insulitis reporter NOD mice by qualitative analysis of sHPAP expression and documented insulitis in NOD mice. [unreadable] [unreadable] [unreadable]..
- IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAEHalina Offner; Fiscal Year: 2010..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
- Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1Ugur Ozerdem; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Proteasomal regulation of TNF-mediated local bone lossLianping Xing; Fiscal Year: 2007..Results from this study should open up a new field of investigation into the involvement of Smurf E3 ligases in inflammation-mediated osteoblast inhibition in erosive bone diseases. [unreadable] [unreadable] [unreadable]..
- Role of Galectin-4 in ColitisAtsushi Mizoguchi; Fiscal Year: 2008..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
- Neuropathology of a Mouse Model for PhenylketonuriaJennifer Embury; Fiscal Year: 2008..In addition, she will have continued exposure to and participation in the molecular biological methods of biomedical research through her involvement in the Laipis laboratory. ..
- Liver to Endocrine Pancreas TransdifferentiationLijun Yang; Fiscal Year: 2009..abstract_text> ..
- Dendritic cell function and ethanolANNETTE SCHLUETER; Fiscal Year: 2007..This in turn will elucidate new approaches for enhancing immunity and preventing infection in alcoholics, as the appropriate points of intervention become clear. ..
- NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASEJessica Moreland; Fiscal Year: 2004....
- Domoic Acid and Neonatal Microglia ActivationAlejandro Mayer; Fiscal Year: 2004..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
- Therapeutic immune mechanisms of daclizumab in psoriasisJames Krueger; Fiscal Year: 2004..We will also measure the impact of daclizumab on T cell activation/deviation towards Type 2 T cells by sensitive flow cytometry based assays. ..
- IMMUNE DYSFUNCTION AND IMMUNOTHERAPY OF RENAL CANCERAugusto Ochoa; Fiscal Year: 2003....
- Novel Ex Vivo Gene Therapy for Spinal Cord InjuryAlpa Trivedi; Fiscal Year: 2004..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
- The Effect of Hypertonic Resuscitation for Blunt TraumaEileen Bulger; Fiscal Year: 2005..abstract_text> ..
- Transdifferentiation of hepatocytesLijun Yang; Fiscal Year: 2005..abstract_text> ..
- CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTESHalina Offner; Fiscal Year: 2005..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
- Prostanoid Modulation of Neuronal DeathNoel Carlson; Fiscal Year: 2005..abstract_text> ..
- Autoimmunity of hepatocyte-derived insulin-producing*Lijun Yang; Fiscal Year: 2005..The information derived from these experiments is critical for translating the results of liver to endocrine pancreas transdifferentiation into clinical application for gene and cell based therapies aimed at curing TIDM. ..
- GENDER INFLUENCES IMMUNOREGULATION IN R EAEHalina Offner; Fiscal Year: 2001....
- Mechanisms of Eosinophil AdhesionXiangdong Zhu; Fiscal Year: 2006..Knowledge of the signaling components required for eosinophil adhesion may provide insight into the pathogenesis of airway inflammation and lead to therapeutic interventions for human asthma. ..
- Therapeutic immune mechanisms of anti-CD11a in psoriasisJames Krueger; Fiscal Year: 2004..Following anti-CD1la we will look for reductions in 1) disease-associated T-cell activation, 2) Type 1 T-cells, and 3) abundance of specific, antigen-reactive T-cells in the peripheral circulation. ..
- THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTIONMartin Schwacha; Fiscal Year: 2003..abstract_text> ..
- PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSISWolfram Ruf; Fiscal Year: 2010..3. ..
- Investigation of Nod2: Implications for UveitisHolly Rosenzweig; Fiscal Year: 2008..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
- Using Genomics to Understand Autoimmune DiabetesJonathan Katz; Fiscal Year: 2006..Aim 3: To establish the differential gene expression pattern associated with disease progression and resistance in NOD recipients of islet-reactive Th1 and Th2 T cells. ..
- TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAYWolfram Ruf; Fiscal Year: 2007..abstract_text> ..
- CSF DEFICIENCY AND ANTITUMOR IMMUNITYGlenn Dranoff; Fiscal Year: 2004..3). To develop strategies for reconstituting tumor defense in mice deficient in GM-CSF, IL-3, and IFN-gamma. ..
- Murine CMV Pneumonitis in Allogeneic BMTOliver Oakley; Fiscal Year: 2005..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
- Monocyte Biology and BiodefenseDOUGLAS DREVETS; Fiscal Year: 2005..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
- Targets of Immune-Mediated Tumor DestructionGlenn Dranoff; Fiscal Year: 2009..Determine whether vaccination with the murine homologs of these antigens can stimulate protective immunity against challenge with murine melanoma cells. ..
- IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENESDOROTHY SEARS; Fiscal Year: 2004..abstract_text> ..
- Cellular pathways of inflammation in type 1 diabetesSridevi Devaraj; Fiscal Year: 2008..abstract_text> ..