cd11b antigens

Summary

Summary: A CD antigen that contains a conserved I domain which is involved in ligand binding. When combined with CD18 the two subunits form MACROPHAGE-1 ANTIGEN.

Top Publications

  1. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
  2. pmc CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 171:1249-57. 2007
  3. pmc Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 13:23-35. 2008
  4. ncbi A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    M T Audrey Nguyen
    Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:35279-92. 2007
  5. ncbi Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    Genevieve Gowing
    Laboratory of Molecular Endocrinology, Centre de Recherche du Centre Hospitalier de l Universite Laval, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
    J Neurosci 28:10234-44. 2008
  6. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
  7. ncbi Stem cell fate specification: role of master regulatory switch transcription factor PU.1 in differential hematopoiesis
    Gurudutta U Gangenahalli
    Stem Cell Gene Therapy Research Group, Institute of Nuclear Medicine and Allied Sciences INMAS, DRDO, Delhi 110054, India
    Stem Cells Dev 14:140-52. 2005
  8. ncbi Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, S San Francisco, California 94080, USA
    Nat Biotechnol 25:911-20. 2007
  9. ncbi CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis
    Bing Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:5228-37. 2007
  10. ncbi CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
    Valeriya P Makarenkova
    Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 176:2085-94. 2006

Detail Information

Publications208 found, 100 shown here

  1. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  2. pmc CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 171:1249-57. 2007
    ..These findings demonstrated that CXCL12-CXCR4 engagement on cutaneous DCs plays a crucial role in the initiation of skin immune response by enhancing cutaneous DC migration...
  3. pmc Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 13:23-35. 2008
    ..Together, these data indicate that Gr-1+CD11b+ cells contribute to TGFbeta-mediated metastasis through enhancing tumor cell invasion and metastasis...
  4. ncbi A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    M T Audrey Nguyen
    Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:35279-92. 2007
    ..Together our results show that FFAs can activate CD11c(+) myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance...
  5. ncbi Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    Genevieve Gowing
    Laboratory of Molecular Endocrinology, Centre de Recherche du Centre Hospitalier de l Universite Laval, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
    J Neurosci 28:10234-44. 2008
    ..This suggests that proliferating microglia-expressing mutant SOD1 are not central contributors of the neurodegenerative process in ALS caused by mutant SOD1...
  6. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
  7. ncbi Stem cell fate specification: role of master regulatory switch transcription factor PU.1 in differential hematopoiesis
    Gurudutta U Gangenahalli
    Stem Cell Gene Therapy Research Group, Institute of Nuclear Medicine and Allied Sciences INMAS, DRDO, Delhi 110054, India
    Stem Cells Dev 14:140-52. 2005
    ..1 at various stages of hematopoietic development beginning from stem cell proliferation, lineage commitment and terminal differentiation into distinct blood cell types, and leukemogenesis...
  8. ncbi Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, S San Francisco, California 94080, USA
    Nat Biotechnol 25:911-20. 2007
    ..These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b+Gr1+ cells...
  9. ncbi CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis
    Bing Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:5228-37. 2007
    ..Further understanding of suppressive monocytes in autoimmune disease models may have important clinical implications for human autoimmune diseases...
  10. ncbi CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
    Valeriya P Makarenkova
    Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 176:2085-94. 2006
    ..Understanding the mechanism of immune suppression by these cells has important clinical implications in the treatment of immune dysfunction after trauma or surgery...
  11. pmc Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1
    Can Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:408-18. 2004
    ..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...
  12. ncbi The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
    Michael Sixt
    Department for Experimental Pathology, Lund University, 22185 Lund, Sweden
    Immunity 22:19-29. 2005
    ..The conduit system is, therefore, not a closed compartment that shuttles substances through the lymph node but represents the morphological equivalent to the filtering function of the lymph node...
  13. pmc The terminology issue for myeloid-derived suppressor cells
    Dmitry I Gabrilovich
    Cancer Res 67:425; author reply 426. 2007
  14. ncbi Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, 27599, USA
    J Allergy Clin Immunol 112:353-61. 2003
    ..Macrophage and neutrophil functions have been reported to be modified by endotoxin in vitro and in vivo, and response to endotoxin is mediated largely by airway phagocytes and related to allergic inflammation...
  15. ncbi Neutrophil infiltration of culprit lesions in acute coronary syndromes
    Takahiko Naruko
    Department of Cardiology, Osaka City General Hospital, Osaka
    Circulation 106:2894-900. 2002
    ..Neutrophils in unstable atherosclerotic lesions have not received much consideration, despite accumulating evidence suggesting a link between systemic inflammation and acute coronary syndromes...
  16. ncbi Fibrinogen-CD11b/CD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophils
    Carolina Rubel
    Division Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    Eur J Immunol 33:1429-38. 2003
    ..These results shed light on the molecular mechanisms that control human granulocyte apoptosis, and suggest that NF-kappa B regulation may be of benefit for the resolution of the inflammatory response...
  17. ncbi Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans
    Neil E Alexis
    National Health and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Clin Immunol 111:126-31. 2004
    ..Consequently, CD11b may be a useful biomarker for predicting susceptibility to airway neutrophilic inflammation caused by pollutants...
  18. ncbi Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG
    Francois Xavier Hubert
    Institut National de la Sante et de la Recherche Medicale, Unite 437, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 1, France
    J Immunol 172:7485-94. 2004
    ..Therefore, rat pDC appear very similar to human pDC, indicating that the specific phenotype and functions of pDC have been highly conserved between species...
  19. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  20. pmc Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
    Kazuichi Maruyama
    Ocular Immunology Group, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2363-72. 2005
    ..The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis...
  21. ncbi CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance
    R William DePaolo
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 171:3560-7. 2003
    ..These data indicate that CCL2 and signaling through its receptor CCR2 is critical for the induction of oral tolerance by regulating Ag presentation leading to a disruption in the balance of inflammatory and regulatory cytokines...
  22. ncbi Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway
    Lydia A Haile
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Gastroenterology 135:871-81, 881.e1-5. 2008
    ..Here, for the first time, we have identified and analyzed their role in inflammatory bowel disease (IBD)...
  23. ncbi Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
    Ping Li
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 50:265-76. 2004
    ..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo...
  24. pmc Collagen-induced arthritis is exacerbated in IL-10-deficient mice
    Alison Finnegan
    Department of Medicine, Section of Rheumatology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R18-24. 2003
    ..Since IL-10 levels are elevated in rheumatoid arthritis synovial fluid, these findings may have relevance to rheumatoid arthritis...
  25. pmc Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis
    Bert De Klerck
    Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Res Ther 6:R220-31. 2004
    ..They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA...
  26. ncbi A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
    Sun Sang J Sung
    Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
    J Immunol 176:2161-72. 2006
    ..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
  27. pmc RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides
    Jana Morova
    Institute of Microbiology of the Academy of Sciences of the Czech Republic, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    Proc Natl Acad Sci U S A 105:5355-60. 2008
    ..These results show that binding and killing of target cells by CyaA, LtxA, and HlyA depends on recognition of N-linked oligosaccharide chains of beta(2) integrin receptors. This sets a new paradigm for action of RTX cytotoxins...
  28. ncbi Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals
    John C Lay
    J Allergy Clin Immunol 120:719-22. 2007
  29. ncbi Bordetella adenylate cyclase toxin: a swift saboteur of host defense
    Jana Vojtova
    Institute of Microbiology of the Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic
    Curr Opin Microbiol 9:69-75. 2006
    ..Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen...
  30. ncbi Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord
    Marie Gingras
    Laboratoire d Organogénèse EXpérimentale LOEX, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital du Saint Sacrement and Département de chirurgie, Faculte de Medecine, Universite Laval, Quebec, Canada G1S 4L8
    J Neurosci Methods 163:111-8. 2007
    ....
  31. pmc Differential response of respiratory dendritic cell subsets to influenza virus infection
    Xueli Hao
    Carter Immunology Center, UVA, P O Box 801386, Charlottesville, VA 22908, USA
    J Virol 82:4908-19. 2008
    ..Our results indicate that RDC are targets of influenza virus infection and that distinct RDC subsets differ in their susceptibilities and responses to infection...
  32. ncbi Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 6:409-21. 2004
    ..Our data provide evidence that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs...
  33. ncbi CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity
    Maria P Lemos
    Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
    J Immunol 171:5077-84. 2003
    ..These findings indicate that DCs are not only key initiators of the primary response, but provide all of the necessary cognate interactions to control CD4(+) T cell fate during the primary immune response...
  34. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  35. pmc Multistable and multistep dynamics in neutrophil differentiation
    Hannah H Chang
    Vascular Biology Program, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Cell Biol 7:11. 2006
    ..However, the dynamics of mammalian cell differentiation has not been analyzed with respect to bistability...
  36. pmc Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice
    Mireia Guerau-de-Arellano
    Department of Pathology, Tufts University School of Medicine, Jaharis 512, 150 Harrison Ave, Boston, MA 02111, USA
    Infect Immun 73:7637-43. 2005
    ..burgdorferi burden relative to that of WT mice. Overall, our results suggest that the increased severity of Lyme carditis in CD18 hypomorph mice is caused by deficiency in CD11a or CD11c, possibly via different mechanisms...
  37. ncbi Activation of peripheral and in vivo transmigrated neutrophils in patients with stable coronary artery disease
    Josefin Paulsson
    Department of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden
    Atherosclerosis 192:328-34. 2007
    ....
  38. ncbi Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response
    Cord Sunderkotter
    Institute of Experimental Dermatology and Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 172:4410-7. 2004
    ..Taken together, these data identify distinct subpopulations of mouse blood monocytes that differ in maturation stage and capacity to become recruited to inflammatory sites...
  39. pmc Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells
    G One Ahn
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive, CCSR South, Room 1255, Stanford, CA 94305, USA
    Cancer Cell 13:193-205. 2008
    ..Our results suggest that MMP-9 could be an important target for adjunct therapy to enhance the response of tumors to radiotherapy...
  40. ncbi Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    ..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
  41. ncbi A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:152-4. 2008
    ..0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development...
  42. ncbi Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
    Jana Kamanova
    Cellular and Molecular Microbiology Division, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
    J Immunol 181:5587-97. 2008
    ....
  43. ncbi Induction of CD69 activation molecule on human neutrophils by GM-CSF, IFN-gamma, and IFN-alpha
    Fabiola Atzeni
    Rheumatology Unit, Ospedale L Sacco, University of Milan, Milan, Italy
    Cell Immunol 220:20-9. 2002
    ..CD69 cross-linking on GM-CSF-primed neutrophils sinergized with LPS and increased TNF-alpha production and secretion suggesting a role for CD69-positive neutrophils in the pathogenesis and maintenance of different inflammatory diseases...
  44. ncbi Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression
    N van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 92:218-25. 2003
    ..However, the local treatment did not preclude systemic effects on atherogenesis, leading to increased atherosclerotic plaque formation and changes in cellular content of plaques...
  45. pmc CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
    Driss Ehirchiou
    Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 204:1519-24. 2007
    ..Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation...
  46. ncbi Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  47. ncbi Reactive microgliosis engages distinct responses by microglial subpopulations after minor central nervous system injury
    Martin Wirenfeldt
    Medical Biotechnology Center, University of Southern Denmark, Odense
    J Neurosci Res 82:507-14. 2005
    ..Our results show that distinct subpopulations of microglia respond to minor CNS injury. The heterogeneity in microglial response may have functional consequences for repair and possibly therapy...
  48. ncbi Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils
    Jie Liu
    Section of Pulmonary and Critical Care Medicine, Department of Medicine MC6076, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Pulm Pharmacol Ther 17:73-9. 2004
    ..IL-5-induced adhesion likely utilizes a different upstream mechanism in regulation of integrin adhesion...
  49. ncbi Cutting Edge: A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytes
    Eiji Esashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    J Immunol 171:2773-7. 2003
    ..Finally, engulfed nuclei were frequently found in CD4(+)/CD11b(+) cells. These results strongly suggest that thymic CD4(+)/CD11b(+) cells are major scavengers of apoptotic thymocytes...
  50. ncbi CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycans
    Ke Zen
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 169:5270-8. 2002
    ..These findings implicate epithelial cell surface proteoglycans decorated with sulfated fucose moieties as ligands for CD11b/CD18 during PMN migration across mucosal surfaces...
  51. ncbi Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)
    H Zhang
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Inflamm Res 52:86-93. 2003
    ..The goal of this study is to investigate the consequence of the interaction between Mac-1 and uPAR and determine the mechanisms by which uPAR regulates Mac-1 dependent adhesion to fibrinogen...
  52. pmc Systemic upregulation of leukocyte integrins in response to lower body ischemia-reperfusion during abdominal aortic aneurysm repair
    Madeleine Valdes Pahl
    Departments of Medicine, University of California Irvine, Irvine, CA, USA
    J Natl Med Assoc 97:172-9. 2005
    ..The mean time to peak expression of CD18 in neutrophils and monocytes during reperfusion was 34.0 and 40.0 minutes in venous and 47.5 and 50.0 minutes in arterial blood, respectively...
  53. ncbi CD11b regulates recruitment of alveolar macrophages but not pulmonary dendritic cells after pneumococcal challenge
    Alun C Kirby
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 193:205-13. 2006
    ..These data demonstrate that there are significant differences between AM and pulDC responses to inflammatory pathogenic stimuli in vivo...
  54. ncbi Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities
    Radovan Fiser
    Department of Genetics and Microbiology, Faculty of Science, Charles University, CZ 128 44, Prague 2
    J Biol Chem 282:2808-20. 2007
    ..Hence, the translocating AC polypeptide itself appears to participate in formation of a novel type of membrane path for calcium ions, contributing to action of CyaA in an unexpected manner...
  55. pmc Migration of polymorphonuclear leucocytes is influenced by dendritic cells
    M Lucila Scimone
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Immunology 114:375-85. 2005
    ..Furthermore, our results also suggest that CXCL8 production by immature DCs might be regulated by signalling through CD31 during their migration through the vascular endothelium...
  56. ncbi Transmigration of blood leukocytes into the peritoneal cavity is related to the upregulation of ICAM-1 (CD54) and Mac-1 (CD11b/CD18) adhesion molecules
    Tomasz Liberek
    Department of Nephrology, Transplantology and Internal Medicine, Gdansk Medical University, Gdansk, Poland
    Perit Dial Int 24:139-46. 2004
    ..To study the role of adhesion molecules in the process of leukocyte transmigration, we compared the expression of several adhesion receptors between peripheral blood monocytes and macrophages isolated from overnight dwell effluents...
  57. ncbi Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] B
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Respir Cell Mol Biol 29:133-47. 2003
    ..These cytokines therefore play a crucial role, via the p38 MAPK and NF-kappaB pathways, in the expression of important adhesion molecules on eosinophils in allergic inflammation...
  58. ncbi A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist
    Grant C Nicholson
    National Heart and Lung Institute NHLI, Clinical Studies Unit, Imperial College London, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Pulm Pharmacol Ther 20:52-9. 2007
    ..Cellular activation can also trigger chemotaxis and shape change, the activation itself being caused by the binding of chemokines to cell surface receptors...
  59. pmc Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes
    Marek Basler
    Institute of Microbiology CAS, Videnska 1083, CZ 142 20 Prague 4, Czech Republic
    Infect Immun 74:2207-14. 2006
    ....
  60. ncbi LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes
    Ki Hoon Han
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Lipid Res 44:1332-40. 2003
    ..In a previous study, we showed that LDL induces the expression of CCR2 in monocytes. We conclude that this may be the underlying cause of the enhanced chemokine effect on CD11b expression and activation observed with these cells...
  61. ncbi A standardized procedure for quantitation of CD11b on polymorphonuclear neutrophil by flow cytometry: potential application in infectious diseases
    V Latger-Cannard
    Laboratory of Hematology, CHU Nancy, Vandoeuvre les Nancy, France
    Clin Lab Haematol 26:177-86. 2004
    ..This method allowed us to evidence an up-regulation of CD11b expression for infected patients. This quantitation is a standardized and potentially useful method in clinical situations implying quantitative CD11b expression variations...
  62. pmc Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
    Ludovic Arnold
    Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
    J Exp Med 204:1057-69. 2007
    ..In conclusion, injured skeletal muscle recruits MOs exhibiting inflammatory profiles that operate phagocytosis and rapidly convert to antiinflammatory MPs that stimulate myogenesis and fiber growth...
  63. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    ..Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen...
  64. ncbi Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice
    Yasushi Sawanobori
    Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Blood 111:5457-66. 2008
    ..Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development...
  65. ncbi Ovarian monocyte progenitor cells: phenotypic and functional characterization
    Cherry J Pascual
    Department of Pediatrics, University of South Florida, St Petersburg, FL 33612, USA
    Stem Cells Dev 14:173-80. 2005
    ..We conclude that in the ovaries, a higher requirement for macrophages is provided by a resident stromal population of progenitors whose progeny is restricted to the production of cells of the monocyte-macrophage lineage...
  66. pmc Interleukin-15 increases neutrophil adhesion onto human respiratory epithelial A549 cells and attracts neutrophils in vivo
    M Pelletier
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, PQ H9R 1G6, Canada
    Clin Exp Immunol 141:315-25. 2005
    ..IL-15 might participate in inflammatory pulmonary diseases by attracting neutrophils, modulating cell surface expression molecules and increasing neutrophil adhesion onto pulmonary cells...
  67. ncbi Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors
    George Hajishengallis
    Center of Excellence in Oral and Craniofacial Biology and Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    J Biol Chem 280:38902-13. 2005
    ..Elucidation of pathogen interactions with PRRs at the molecular level may glean insight into host defense mechanisms as well as into microbial strategies that subvert innate immunity...
  68. ncbi [Effect of cardiopulmonary bypass on CD11/CD18 expression of neutrophils in children undergoing cardiac surgery]
    Qiang Shu
    The Affiliated Children s Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:66-70. 2007
    ..To investigate the changes in perioperative expression level of CD11/CD18 of neutrophils in children undergoing cardiac surgery with cardiopulmonary bypass (CPB)...
  69. ncbi Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation
    Driss El Kebir
    Research Center, Maisonneuve Rosemont Hospital, University of Montreal, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
    Circ Res 103:352-9. 2008
    ..Our results indicate that MPO functions as a survival signal for neutrophils and thereby contribute to prolongation of inflammation...
  70. ncbi Ovarian cancer cells modulate human blood neutrophils response to activation in vitro
    M Klink
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Scand J Immunol 68:328-36. 2008
    ..Our results suggest the possibility that neutrophils responding to contact with cancer cells contribute to the progression and metastatic potential of tumour cells...
  71. ncbi Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression
    Cristina Lecchi
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Italy
    Vet Res 39:50. 2008
    ....
  72. ncbi Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils
    J J Liu
    Laboratory of Molecular Biology, Luzhou Medical College, Sichuan 646000, China
    Inflamm Res 54:500-7. 2005
    ....
  73. ncbi CD157 is part of a supramolecular complex with CD11b/CD18 on the human neutrophil cell surface
    L Lavagno
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    J Biol Regul Homeost Agents 21:5-11. 2007
    ..These results confirm that CD157 physically interacts with CD11b/CD18 complex in human neutrophils...
  74. ncbi Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro
    M Klink
    Centre for Medical Biology, Polish Academy of Sciences, 93 232, Lodz, Lodowa 106, Poland
    Inflamm Res 56:282-90. 2007
    ..We investigated the intracellular signalling pathways by which nitric oxide (NO) donors: diethylamine/NO (DEA/NO) and 3-morpholinosydnonimine (SIN-1) regulate the functional response of human neutrophils to activating stimuli...
  75. ncbi Platelet activation, upregulation of CD11b/ CD18 expression on leukocytes and increase in circulating leukocyte-platelet aggregates in Indian women chronically exposed to biomass smoke
    M R Ray
    Experimental Hematology Unit, Chittaranjan National Cancer Institute, Kolkata 700 026, India
    Hum Exp Toxicol 25:627-35. 2006
    ..The results show that chronic biomass smoke exposure activates circulating platelets, PMN and monocytes, and increases the number of leukocyte-platelet aggregates, which are considered a risk factor for thrombosis...
  76. ncbi Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on LPS-induced mesenteric microcirculatory disturbance in rats
    Jun Guo
    Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China
    Shock 29:205-11. 2008
    ..Treatment with DLA or SAB significantly ameliorated LPS-induced microcirculatory disturbance in rat mesentery and inhibited both the expression of CD11b and CD18 and the production of *O2- and H2O2 by neutrophils caused by LPS...
  77. ncbi Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors
    Yuka Sugimoto
    Department of Haematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan
    Br J Haematol 135:725-31. 2006
    ..Our data may also offer one explanation for the rapid recovery of monocytes in comparison with neutrophils in the early phase of haematopoietic regeneration...
  78. pmc Src family kinases mediate neutrophil adhesion to adherent platelets
    Virgilio Evangelista
    Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
    Blood 109:2461-9. 2007
    ..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...
  79. ncbi TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae
    Evlambia Harokopakis
    Center for Oral Health and Systemic Disease, University of Louisville Health Sciences Center, KY 40292, USA
    J Immunol 176:7645-56. 2006
    ..Thus, P. gingivalis fimbriae activate a novel proadhesive pathway in human monocytes, involving TLR2, Rac1, PI3K, and CD11b/CD18, which may constitute a mechanistic basis linking P. gingivalis to inflammatory atherosclerotic processes...
  80. ncbi Polymorphonuclear leukocyte integrins in chronic renal failure
    Gregorio Caimi
    Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universita di Palermo, Palermo, Italy
    Clin Hemorheol Microcirc 32:43-9. 2005
    ..The altered behaviour of the PMN integrin pattern in mild CRF patients, likely reflecting a state of PMN activation, might have a pathophysiological significance, considering the high incidence of cardiovascular events in CRF...
  81. ncbi Induction of polymorphonuclear leukocyte response by human cytomegalovirus
    Petra Jerström Skarman
    Department of Medicine, Center for Molecular Medicine, L8 03, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Microbes Infect 8:1592-601. 2006
    ..Instead, the fact that apoptosis is inhibited may cause over-reactive neutrophils to remain in the tissues, where they will start leaking their contents, damaging the tissues and contributing to inflammatory processes...
  82. ncbi Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms
    Hitoshi Nakayama
    Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2 1 1 Tomioka, Urayasu, Chiba 279 0021, Japan
    J Leukoc Biol 83:728-41. 2008
    ..Taken together, these observations suggest that CD11b activation causes translocation of CD11b/CD18 into Lyn-coupled, LacCer-enriched lipid rafts, allowing neutrophils to phagocytose NOZs via CD11b/CD18...
  83. ncbi Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra)
    Evlambia Harokopakis
    Department of Pedodontics, School of Dentistry, Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Periodontol 77:271-9. 2006
    ....
  84. ncbi Alterations of CD43 expression in transfusion-dependent myelodysplastic syndromes
    E Kyriakou
    Department of Hematology, University Hospital of Thessalia, Larissa, Greece
    Ann Hematol 85:281-4. 2006
    ..Given together, these results show that decreased CD43 in the transfused group of MDS patients is associated with an activated endothelial phenotype...
  85. ncbi ICAM-1 and CD11b/CD18 expression during acute pancreatitis induced by bile-pancreatic duct obstruction: effect of N-acetylcysteine
    Laura Ramudo
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Exp Biol Med (Maywood) 232:737-43. 2007
    ....
  86. ncbi Inhibitory effects of catechins on neutrophil-dependent gastric inflammation
    Osamu Handa
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachidori Hirokouji Agaru, Kyoto, Japan
    Redox Rep 7:324-8. 2002
    ..These results suggest that tea may inhibit carcinogenesis partly through the anti-inflammatory effects of tea catechins on PMN-dependent gastric mucosal inflammation...
  87. ncbi Leptin indirectly activates human neutrophils via induction of TNF-alpha
    Hamid Zarkesh-Esfahani
    Division of Clinical Sciences North, University of Sheffield, Sheffield, United Kingdom
    J Immunol 172:1809-14. 2004
    ..In conclusion, although leptin activates PMN, it does so indirectly via TNF-alpha release from monocytes. These findings provide an additional link among the obesity-derived hormone leptin, innate immune function, and infectious disease...
  88. ncbi Stimulation of neutrophil apoptosis by immobilized IgA
    Jorge Schettini
    Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, and Laboratory of Immunogenetics, Department of Microbiology, Buenos Aires University School of Medicine, Argentina
    J Leukoc Biol 72:685-91. 2002
    ..Stimulation of neutrophil apoptosis by IgA might contribute to the control of inflammatory processes in certain autoimmune diseases such as IgA nephropathy in which tissue deposits of IgA or IgA containing immune complexes are found...
  89. ncbi Evaluation of leukocyte cell surface markers in dogs with septic and nonseptic inflammatory diseases
    Douglas J Weiss
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Am J Vet Res 65:59-63. 2004
    ..To determine whether functional alterations in neutrophils and mononuclear leukocytes are a consistent finding in dogs with inflammatory disease...
  90. pmc Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids
    P Ballabh
    Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
    Arch Dis Child Fetal Neonatal Ed 89:F76-83. 2004
    ....
  91. ncbi The effect of (1-->3)-beta-D-glucans, carboxymethylglucan and schizophyllan on human leukocytes in vitro
    Lukas Kubala
    Institute of Biophysics Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Carbohydr Res 338:2835-40. 2003
    ..The higher potency of SPG to stimulate human blood phagocytes in vitro could be caused by factors such as higher branching frequencies or neutral polymer charge of SPG or different conformation in solution if compared with CMG...
  92. ncbi Social stress alters splenocyte phenotype and function
    Ronit Avitsur
    Section of Oral Biology, The Ohio State University Health Sciences Center, Columbus, OH, USA
    J Neuroimmunol 132:66-71. 2002
    ..Together, these findings indicate that social stress altered phenotype and function of splenic immune cells. These findings may have implications for the healing of bite wounds that are often associated with social stress in rodents...
  93. ncbi Function of the lectin domain of Mac-1/complement receptor type 3 (CD11b/CD18) in regulating neutrophil adhesion
    Yu Xia
    Chemoattractant Group of the James Graham Brown Cancer Center, Department of Pathology, University of Louisville, KY 40202, USA
    J Immunol 169:6417-26. 2002
    ..These data indicate that the same lectin domain within CD11b regulates both the cytotoxic and adhesion functions of Mac-1/CR3...
  94. ncbi Circadian variation in cell-adhesion molecule expression by normal human leukocytes
    Gary D Niehaus
    Department of Physiology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Box 95, Rootstown, OH 44272, USA
    Can J Physiol Pharmacol 80:935-40. 2002
    ....
  95. ncbi Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice
    Dori L Borjesson
    Center for Comparative Medicine, Schools of Medicine Veterinary Medicine, University of California, Davis 95616, USA
    Blood 101:3257-64. 2003
    ..Establishment of feeding pools that rely less on leukocyte trafficking and more on small hemorrhages may explain the ready amplification of A phagocytophila DNA from ticks infested on CD11/CD18-deficient mouse strains...
  96. ncbi Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis
    Jenny Jongstra-Bilen
    Cell Biology Program, Hospital for Sick Children and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:45720-9. 2003
    ..FcgammaR can enhance host defense by activating Mac-1 (and possibly other integrins), having a synergistic effect on pathogen engulfment and promoting the adherence of phagocytes at sites of infection...
  97. ncbi Glutamine improves impaired cellular exudation and polymorphonuclear neutrophil phagocytosis induced by total parenteral nutrition after glycogen-induced murine peritonitis
    Shigeo Ikeda
    Department of Surgery, The University of Wisconsin, Madison, Wisconsin 53792, USA
    Shock 19:50-4. 2003
    ..06). There were no significant differences in ROI production or CD11b and CD16/32 expression on peritoneal PMN. GLN supplementation improved the reduction in cell exudation and PMN phagocytosis induced by TPN after chemical peritonitis...
  98. ncbi L-selectin and beta2-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitis
    A Diez-Fraile
    Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Dairy Sci 86:2334-42. 2003
    ..The knowledge of adhesion molecule kinetics in relation to the different parameters evaluated in the present study contributes to an improved understanding of the inflammatory reaction...
  99. pmc Expression of beta2-integrin on monocytes and blood polymorphonuclear leukocytes in the periparturient period in dairy cows
    Araceli Diez-Fraile
    Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Can J Vet Res 67:235-8. 2003
    ..In this study, the decreased number of milk resident macrophages and PMN observed during the periparturient period could not be attributed to changes of CD11/CD18 levels on circulating leukocytes...
  100. ncbi Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  101. ncbi The strength of integrin binding between neutrophils and endothelial cells
    V Labrador
    Cell and Tissue Mechanics and Engineering, LEMTA UMR CNRS 7563, Faculty of Medicine, 54505 Vandoeuvre les Nancy, France
    Eur Biophys J 32:684-8. 2003
    ..Analysis of the flow dependence of the number of attached cells reveals the prevailing number of neutrophils with stronger binding to the endothelium when both cells are in the activated state in comparison with non-activated cells...

Research Grants50

  1. Recruitment of Murine Mast Cell Progenitors
    JUAN ABONIA; Fiscal Year: 2007
    ..The aim of this proposal is to identify those pathways which are responsible for inflammatory recruitment of MCp to the lung and intestine. ..
  2. CELL SURFACE ANTIGENS ON HUMAN MACROPHAGES
    Robert Todd; Fiscal Year: 1999
    ..It is the goal of this investigation to test the hypothesis that cooperative interactions among neutrophil receptors govern the neutrophil response to certain external stimuli and contribute to host immunity. ..
  3. Experimental Uveal Melanoma and Ocular Immune Privilege
    KYLE MCKENNA; Fiscal Year: 2007
    ..abstract_text> ..
  4. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  5. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  6. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2008
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  8. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  9. The Role of KLF6 Tumor Suppressor in Hepatocellular Cancer
    SCOTT LAURENCE FRIEDMAN; Fiscal Year: 2010
    ..abstract_text> ..
  10. Oligodendrocyte Progenitors in Spinal Cord Injury Repair
    DANA MCTIGUE; Fiscal Year: 2006
    ..abstract_text> ..
  11. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  12. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  13. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  14. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  15. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  16. Insulin producing cells generated in vitro from hepatic stem cells
    Lijun Yang; Fiscal Year: 2007
    ..abstract_text> ..
  17. The Insulitis Reporter Mouse
    Jonathan Katz; Fiscal Year: 2007
    ..Specific Aim 2: To validate the specificity and sensitivity of the insulitis reporter NOD mice by qualitative analysis of sHPAP expression and documented insulitis in NOD mice. [unreadable] [unreadable] [unreadable]..
  18. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2010
    ..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
  19. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Proteasomal regulation of TNF-mediated local bone loss
    Lianping Xing; Fiscal Year: 2007
    ..Results from this study should open up a new field of investigation into the involvement of Smurf E3 ligases in inflammation-mediated osteoblast inhibition in erosive bone diseases. [unreadable] [unreadable] [unreadable]..
  21. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  22. Neuropathology of a Mouse Model for Phenylketonuria
    Jennifer Embury; Fiscal Year: 2008
    ..In addition, she will have continued exposure to and participation in the molecular biological methods of biomedical research through her involvement in the Laipis laboratory. ..
  23. Liver to Endocrine Pancreas Transdifferentiation
    Lijun Yang; Fiscal Year: 2009
    ..abstract_text> ..
  24. Dendritic cell function and ethanol
    ANNETTE SCHLUETER; Fiscal Year: 2007
    ..This in turn will elucidate new approaches for enhancing immunity and preventing infection in alcoholics, as the appropriate points of intervention become clear. ..
  25. NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASE
    Jessica Moreland; Fiscal Year: 2004
    ....
  26. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
  27. Therapeutic immune mechanisms of daclizumab in psoriasis
    James Krueger; Fiscal Year: 2004
    ..We will also measure the impact of daclizumab on T cell activation/deviation towards Type 2 T cells by sensitive flow cytometry based assays. ..
  28. IMMUNE DYSFUNCTION AND IMMUNOTHERAPY OF RENAL CANCER
    Augusto Ochoa; Fiscal Year: 2003
    ....
  29. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
  30. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  31. Transdifferentiation of hepatocytes
    Lijun Yang; Fiscal Year: 2005
    ..abstract_text> ..
  32. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2005
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  33. Prostanoid Modulation of Neuronal Death
    Noel Carlson; Fiscal Year: 2005
    ..abstract_text> ..
  34. Autoimmunity of hepatocyte-derived insulin-producing*
    Lijun Yang; Fiscal Year: 2005
    ..The information derived from these experiments is critical for translating the results of liver to endocrine pancreas transdifferentiation into clinical application for gene and cell based therapies aimed at curing TIDM. ..
  35. GENDER INFLUENCES IMMUNOREGULATION IN R EAE
    Halina Offner; Fiscal Year: 2001
    ....
  36. Mechanisms of Eosinophil Adhesion
    Xiangdong Zhu; Fiscal Year: 2006
    ..Knowledge of the signaling components required for eosinophil adhesion may provide insight into the pathogenesis of airway inflammation and lead to therapeutic interventions for human asthma. ..
  37. Therapeutic immune mechanisms of anti-CD11a in psoriasis
    James Krueger; Fiscal Year: 2004
    ..Following anti-CD1la we will look for reductions in 1) disease-associated T-cell activation, 2) Type 1 T-cells, and 3) abundance of specific, antigen-reactive T-cells in the peripheral circulation. ..
  38. THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTION
    Martin Schwacha; Fiscal Year: 2003
    ..abstract_text> ..
  39. PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSIS
    Wolfram Ruf; Fiscal Year: 2010
    ..3. ..
  40. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  41. Using Genomics to Understand Autoimmune Diabetes
    Jonathan Katz; Fiscal Year: 2006
    ..Aim 3: To establish the differential gene expression pattern associated with disease progression and resistance in NOD recipients of islet-reactive Th1 and Th2 T cells. ..
  42. TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAY
    Wolfram Ruf; Fiscal Year: 2007
    ..abstract_text> ..
  43. CSF DEFICIENCY AND ANTITUMOR IMMUNITY
    Glenn Dranoff; Fiscal Year: 2004
    ..3). To develop strategies for reconstituting tumor defense in mice deficient in GM-CSF, IL-3, and IFN-gamma. ..
  44. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  45. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  46. Targets of Immune-Mediated Tumor Destruction
    Glenn Dranoff; Fiscal Year: 2009
    ..Determine whether vaccination with the murine homologs of these antigens can stimulate protective immunity against challenge with murine melanoma cells. ..
  47. IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    DOROTHY SEARS; Fiscal Year: 2004
    ..abstract_text> ..
  48. Cellular pathways of inflammation in type 1 diabetes
    Sridevi Devaraj; Fiscal Year: 2008
    ..abstract_text> ..