differentiation antigens

Summary

Summary: Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

Top Publications

  1. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
  2. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
  3. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
  4. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
  5. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
  6. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
  7. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
  8. pmc Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    I Novoa
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 153:1011-22. 2001
  9. ncbi The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses
    Beatriz M Carreno
    Genetics Institute Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Annu Rev Immunol 20:29-53. 2002
  10. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001

Research Grants

Detail Information

Publications259 found, 100 shown here

  1. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  2. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  3. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
    ..The TLR-induced inflammatory response is dependent on a common signaling pathway that is mediated by the adaptor molecule MyD88. However, there is evidence for additional pathways that mediate TLR ligand-specific biological responses...
  4. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8...
  5. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  6. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  7. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  8. pmc Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    I Novoa
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 153:1011-22. 2001
    ....
  9. ncbi The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses
    Beatriz M Carreno
    Genetics Institute Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Annu Rev Immunol 20:29-53. 2002
    ..Understanding these pathways will allow development of new strategies for therapeutic intervention in immune-mediated diseases...
  10. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
    ..The implications of these complexities and the potential for use of these therapies in clinical immune intervention are discussed...
  11. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
    ..Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation...
  12. pmc Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2
    Matthew H Brush
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 23:1292-303. 2003
    ..These data provide new insights into the mode of action of GADD34 in assembling an ER-associated eIF-2 alpha phosphatase that regulates protein translation in mammalian cells...
  13. ncbi The SIRP family of receptors and immune regulation
    A Neil Barclay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 6:457-64. 2006
    ..In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation...
  14. ncbi Toll-like receptor signalling
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Rev Immunol 4:499-511. 2004
  15. pmc Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    T Takahashi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 192:303-10. 2000
    ..This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity...
  16. ncbi TIRAP: an adapter molecule in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:835-41. 2001
    ..We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways...
  17. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
  18. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  19. ncbi Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    E A Tivol
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 3:541-7. 1995
    ..In the absence of CTLA-4, peripheral T cells are activated, can spontaneously proliferate, and may mediate lethal tissue injury...
  20. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
    ....
  21. ncbi B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 6:303-13. 1997
    ..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2...
  22. ncbi Integrin-associated protein (CD47) and its ligands
    E J Brown
    Program in Host Pathogen Interactions, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Cell Biol 11:130-5. 2001
    ....
  23. ncbi Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    Jackson G Egen
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California at Berkeley, Berkeley, CA 94720, USA
    Immunity 16:23-35. 2002
    ..This may represent a novel feedback control mechanism in which a stimulatory signal regulates the recruitment of an inhibitory receptor to a functionally relevant site on the cell surface...
  24. ncbi IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
    ..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
  25. pmc CTLA-4 is a second receptor for the B cell activation antigen B7
    P S Linsley
    Oncogen Division, Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    J Exp Med 174:561-9. 1991
    ..Lymphocyte interactions involving the B7 counter-receptor are functionally important for alloantigen responses in vitro...
  26. ncbi CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms
    A Ligers
    Division of Neurology, Neurotec, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Genes Immun 2:145-52. 2001
    ..Thus, we propose that the susceptibility-influencing role of CTLA4 in MS may be related to genotypically conditioned promoter function, whereby high gene expression may decrease the risk of disease...
  27. ncbi Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  28. ncbi Endotoxin-induced maturation of MyD88-deficient dendritic cells
    T Kaisho
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 166:5688-94. 2001
    ..Collectively, the present study provides the first evidence that the MyD88-independent pathway downstream of TLR4 can lead to functional DC maturation, which is critical for a link between innate and adaptive immunity...
  29. pmc The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 195:953-8. 2002
    ..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture...
  30. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
    ..Therefore, these results demonstrate a novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-alpha by pDCs...
  31. ncbi Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    P Waterhouse
    Department of Immunology, University of Toronto, Ontario, Canada
    Science 270:985-8. 1995
    ..Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis...
  32. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
    ..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
  33. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
    ....
  34. ncbi Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
    C C Stamper
    Departments of Biological Chemistry and Musculoskeletal Sciences, Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Nature 410:608-11. 2001
    ..This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses...
  35. ncbi CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases
    Christine Guntermann
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Program, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 168:4420-9. 2002
    ..Collectively, our findings suggest that CTLA-4 can act early during the immune response to regulate the threshold of T cell activation...
  36. ncbi Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47
    M Seiffert
    University of Tubingen, the Department of Internal Medicine II, Tubingen, Germany
    Blood 94:3633-43. 1999
    ..In this study, we identify CD47 as the extracellular ligand for human SIRP and show that these two counterreceptors are involved in cellular adhesion...
  37. ncbi Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells
    Peter L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:360-9. 2003
    ....
  38. ncbi Integrin-associated protein is a ligand for the P84 neural adhesion molecule
    P Jiang
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 274:559-62. 1999
    ..Because IAP has been implicated in cell signaling in cells of the immune system, P84 and IAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and in other tissues...
  39. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  40. ncbi B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    B Salomon
    Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 12:431-40. 2000
    ..The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases...
  41. ncbi Cutting edge: reversal of murine lupus nephritis with CTLA4Ig and cyclophosphamide
    D I Daikh
    Department of Medicine, Department of Veterans Affairs Medical Center and the University of California, San Francisco, CA 94121, USA
    J Immunol 166:2913-6. 2001
    ..This striking reversal of proteinuria is unprecedented in animal models of SLE...
  42. ncbi Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    K Hoebe
    Department of Immunology, IMM 31, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 424:743-8. 2003
    ..This reveals that an alternative MyD88-dependent 'adaptor X' pathway is present in some, but not all, macrophages, and implies afferent immune specialization...
  43. pmc Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanoma
    Paul F Robbins
    Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B42, Bethesda, MD 20892 7502, USA
    J Immunol 169:6036-47. 2002
    ..These observations provide an impetus to develop strategies directed toward generating HLA class II-restricted tumor-reactive T cells...
  44. ncbi BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    Norihiko Watanabe
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Immunol 4:670-9. 2003
    ..B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1)...
  45. ncbi The interaction properties of costimulatory molecules revisited
    Alison V Collins
    Nuffield Department of Clinical Medicine, The University of Oxford, John Radcliffe Hospital, Headington, United Kingdom
    Immunity 17:201-10. 2002
    ..We propose that the distinct structures and binding properties of B7-1 and B7-2 account for their overlapping but distinct effects on T cell responses...
  46. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
    ....
  47. ncbi CD28/B7 costimulation: a review
    E A Greenfield
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Crit Rev Immunol 18:389-418. 1998
    ..Thus, the B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses...
  48. ncbi Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    Hironori Ueda
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nature 423:506-11. 2003
    ..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction...
  49. ncbi Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    A A Hurwitz
    Cancer Research Laboratory, University of California, Berkeley 94720, USA
    Cancer Res 60:2444-8. 2000
    ..These findings demonstrate that this combinatorial treatment can elicit a potent antiprostate response and suggest potential of this approach for treatment of prostate cancer...
  50. ncbi Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
    C A Chambers
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of California, Berkeley 94720, USA
    Immunity 7:885-95. 1997
    ..These results demonstrate that CD4+ T cells initiate the phenotype in the CTLA-4(-/-) mice. Further, these results suggest that the role of CTLA-4 in peripheral CD4+ versus CD8+ T cell homeostasis is distinct...
  51. ncbi High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
    A Veillette
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Biol Chem 273:22719-28. 1998
    ..Taken together, these findings indicate that SHPS-1 is likely to play a significant role in macrophages, at least partially as a consequence of its capacity to recruit SHP-1...
  52. pmc Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
    J Exp Med 193:1295-302. 2001
    ....
  53. ncbi The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice
    Eiji Kojima
    Department of Basic Gerontology, National Institute for Longevity Sciences, 36 3, Gengo, Morioka cho, Obu, Aichi 474 8522, Japan
    FASEB J 17:1573-5. 2003
    ..These results indicate that GADD34 works as a sensor of ER stress stimuli and recovers cells from shutoff of protein synthesis...
  54. ncbi BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood
    A Dzionek
    Miltenyi Biotec GmbH, Bergisch Gladbach, Germany AmCell Corporation, Sunnyvale, CA 94089, USA
    J Immunol 165:6037-46. 2000
    ..The three presumably novel Ags serve as specific markers for the respective subpopulations of blood dendritic cells in fresh blood and will be of great value for their further analysis and to evaluate their therapeutic potential...
  55. ncbi The role of the CD28 receptor during T cell responses to antigen
    P S Linsley
    Department of Cellular Immunology, Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    Annu Rev Immunol 11:191-212. 1993
    ..The CD28 costimulatory receptor represents a novel target for immunosuppressive drugs...
  56. ncbi Toll-like receptor signaling pathways
    Gregory M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, CABS660, New Haven, CT 06520, USA
    Science 300:1524-5. 2003
    ..TLRs and their pathways are numerous; Science's Signal Transduction Knowledge Environment's TLR Connections Map provides an immediate, clear overview of the known components and relations of this complex system...
  57. ncbi CTLA-4 regulates induction of anergy in vivo
    R J Greenwald
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    Immunity 14:145-55. 2001
    ..Thus, CTLA-4 has an essential role in determining the outcome of T cell encounter with a tolerogenic stimulus...
  58. ncbi Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  59. ncbi The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Solution Oriented Research for Science and Technology, Japan Science and Technology Corp, Suita, Osaka, Japan
    J Immunol 170:3059-64. 2003
    ..This study demonstrates that the TLR9-MyD88 signaling pathway is essential for all DC responses to both types of CpG DNAs...
  60. ncbi A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells
    G Magistrelli
    Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
    Eur J Immunol 29:3596-602. 1999
    ..These results suggest that nonstimulated T cells may constitutively produce a soluble form of CTLA-4 which may have an important role in the regulation of immune homeostasis...
  61. pmc Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
    A Iellem
    Roche Milano Ricerche, Milano I-20132, Italy
    J Exp Med 194:847-53. 2001
    ..Overall, these results suggest that CCR4 and/or CCR8 may guide Treg cells to sites of antigen presentation in secondary lymphoid tissues and inflamed areas to attenuate T cell activation...
  62. ncbi Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    Taro Kawai
    ERATO, Akira Innate Immunity Program, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 5:1061-8. 2004
    ..These results indicate that TLR-mediated IFN-alpha induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination...
  63. ncbi Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    T Kawai
    Department of Host Defense, Research Institute for Microbial Diseases, Japan Science and Technology Corporation, Osaka University, Osaka, Japan
    J Immunol 167:5887-94. 2001
    ....
  64. ncbi Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
    ..Together these data suggest that the interaction of CTLA-4 with AP50 plays an important role in regulating the cell surface expression of CTLA-4...
  65. ncbi A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation
    Mathias Maurer
    Department of Neurology, Bayerische Julius Maximilians Universität, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Immunogenetics 54:1-8. 2002
    ..Our results suggest that the G allele at position +49 of exon 1 affects the CTLA4-driven down-regulation of T-cell activation and may be an important factor in the pathogenesis of autoimmune diseases...
  66. ncbi B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 172:2530-41. 2004
    ..These results suggest a unique role for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but PD-1-independent, mechanism...
  67. ncbi T cell anergy
    Ronald H Schwartz
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    Annu Rev Immunol 21:305-34. 2003
    ..Aspects of both of the anergic states are found in regulatory T cells, possibly preventing them from dominating initial immune responses to foreign antigens and shutting down such responses prematurely...
  68. ncbi Cross-reactivity of monoclonal antibodies to defined human leucocyte differentiation antigens with bovine cells
    P Sopp
    Institute for Animal Health, Compton Laboratory, Newbury, Berkshire, UK
    Vet Immunol Immunopathol 56:11-25. 1997
    ..of monoclonal antibodies (mAbs) included within the Vth International Workshop on Human Leucocyte Differentiation Antigens (Vth Workshop) were assayed for reactivity with bovine peripheral blood leucocytes...
  69. ncbi CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults
    Anna Cosentino
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 958:337-40. 2002
    ..028). The results of our study show that LADA is positively associated with the CTLA-4 A/G genotype, similarly to T1DM, thus providing further supporting evidence of the autoimmune origin of this form of diabetes mellitus of the adult...
  70. pmc MFR, a putative receptor mediating the fusion of macrophages
    C Saginario
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA
    Mol Cell Biol 18:6213-23. 1998
    ..MFR is identical to SHPS-1 and BIT and is a homologue of P84, SIRPalpha, and MyD-1, all of which have been recently cloned and implicated in cell signaling and cell-cell interaction events...
  71. pmc Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
    Y Zhang
    Department of Molecular and Cellular Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:9273-8. 1997
    ..These results suggest that AP50 and the coated pit adaptor complex AP2 may play an important role in regulating the intracellular trafficking and function of CTLA-4...
  72. ncbi Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    Lieping Chen
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Rev Immunol 4:336-47. 2004
  73. ncbi TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..TLR4- but not TLR3-mediated MyD88-independent interferon-beta production and activation of signaling cascades were abolished in TRAM-deficient cells. Thus, TRAM provides specificity for the MyD88-independent component of TLR4 signaling...
  74. ncbi Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells
    Katsuto Takenaka
    Division of Cellular and Molecular Biology, University Health Network, Toronto, Ontario M5G2M9, Canada
    Nat Immunol 8:1313-23. 2007
    ..Thus, we have identified Sirpa polymorphism as a potent genetic determinant of the engraftment of human hematopoietic stem cells...
  75. ncbi CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population
    Yu Ching Weng
    Clinical Laboratory, SinLau Children Hospital, Taiwan, ROC
    Ann Clin Lab Sci 35:259-64. 2005
    ..In conclusion, we provide evidence that CT60 SNP is associated with susceptibility to GD in the Taiwanese population...
  76. ncbi MyD88, an adapter protein involved in interleukin-1 signaling
    K Burns
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    J Biol Chem 273:12203-9. 1998
    ..MyD88 coimmunoprecipitates with the IL-1R signaling complex in an IL-1-dependent manner...
  77. pmc Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1
    J H Connor
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 21:6841-50. 2001
    ..These studies suggested that modification of the I-1/GADD34/PP1 signaling complex regulates the initiation of protein translation in mammalian tissues...
  78. ncbi CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm
    Monica Cheng Munthe-Kaas
    Department of Pediatrics, Ulleval University Hospital, University of Oslo, Norway
    J Allergy Clin Immunol 114:280-7. 2004
    ..This region harbors the candidate gene cytotoxic T-lymphocyte antigen 4 (CTLA-4), an important regulator of T-cell activation and differentiation...
  79. ncbi Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness
    T L Vanasek
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 167:5636-44. 2001
    ..CTLA-4 molecules promote clonal anergy development only indirectly by limiting cell cycle progression during the primary response...
  80. ncbi Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population
    Yoshiyuki Ban
    Third Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Autoimmunity 38:151-3. 2005
    ..004, odds ratio (OR)=2.0] and AITD (P=0.03,OR=1.6) in a recessive model. These results suggested that the CTLA-4 gene is involved in the susceptibility for GD and AITD in the Japanese...
  81. ncbi Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B
    Nickolay Neznanov
    Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 278:3809-15. 2003
    ..These data indicate that SIRPalpha/SHPS-1 is involved in negative regulation of NF-kappaB signaling...
  82. ncbi Highly sensitive multivariable assay detection of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes with melanoma micrometastases
    Dominique Vitoux
    Unité Fonctionnelle Diagnostic Biologique Automatise, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7151, Paris, France
    Arch Dermatol 145:1105-13. 2009
    To evaluate the prognostic value of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes (SLNs) with melanoma micrometastases.
  83. ncbi Embryonic implantation in galectin 1/galectin 3 double mutant mice
    C Colnot
    Unité INSERM 257, ICGM, Paris, France
    Dev Dyn 211:306-13. 1998
    ..We find that implantation can still occur in the absence of both galectin 1 and galectin 3. However, we show that galectin 5, a third member of this gene family, is also present in the blastocyst at the time of implantation...
  84. pmc Stress-induced gene expression requires programmed recovery from translational repression
    Isabel Novoa
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    EMBO J 22:1180-7. 2003
    ....
  85. ncbi Regulatory T cells in the control of immune pathology
    K J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Immunol 2:816-22. 2001
    ..We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function...
  86. pmc Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens
    Matthias Mayerhofer
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    J Immunol 180:5466-76. 2008
    ..Based on all these results, it is hypothesized that KIT D816V as a single hit may be sufficient to cause indolent systemic mastocytosis, whereas additional defects may be required to induce aggressive mast cell disorders...
  87. ncbi MyD88 as a bottle neck in Toll/IL-1 signaling
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Top Microbiol Immunol 270:155-67. 2002
    ..Analysis of MyD88-deficient mice revealed its essential role in TLR/IL-1R signaling as well as in both the innate and the adaptive immune response...
  88. ncbi Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88
    Sophie Janssens
    Department of Molecular Biology, Unit of Molecular Signal Transduction in Inflammation, Gent University VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Curr Biol 12:467-71. 2002
    ..Moreover, the regulated expression and antagonistic activity of MyD88(S) suggest an important role for alternative splicing of MyD88 in the regulation of the cellular response to IL-1 and LPS...
  89. ncbi Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Blood 103:1433-7. 2004
    ....
  90. pmc CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    A A Hurwitz
    Howard Hughes Medical Institute, Cancer Research Laboratory, University of California at Berkeley, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 95:10067-71. 1998
    ..In addition, these results also support the idea that the most effective and synergistic vaccine strategy targets treatments that enhance T cell priming at the level of host-derived antigen-presenting cells...
  91. ncbi Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer
    N Erfani
    Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
    Cancer Genet Cytogenet 165:114-20. 2006
    ..004), and the -318 CC genotype with lesser LN involvement (P = 0.007). These results suggest that CTLA4 promoter variants participate in the progression of breast cancer rather than in its initial development...
  92. pmc Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae
    Victoria Gillan
    Parasitology Group, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Infect Immun 73:4034-42. 2005
    ..These results suggest a complex network of regulation in L3-infected mice with Th2 cells limiting the Th1 response, while T-regulatory cells modulate Th2 responses...
  93. ncbi From form to function: signaling by protein tyrosine phosphatases
    N K Tonks
    Cold Spring Harbor Laboratory, New York 11724 2208, USA
    Cell 87:365-8. 1996
  94. ncbi Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
    T Shiratori
    Division of Molecular Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Japan
    Immunity 6:583-9. 1997
    ..Our results suggest that the phosphorylation state of a single tyrosine residue determines whether CTLA-4 delivers a negative signal or is internalized...
  95. pmc A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion
    Y Fujioka
    Second Department of Internal Medicine, Kobe University School of Medicine, Chuo Ku, Japan
    Mol Cell Biol 16:6887-99. 1996
    ..In addition, we suggest that SHPS-1 may be a potential substrate for SHP-2 and may function in both growth factor- and cell adhesion-induced cell signaling...
  96. pmc Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
    D Dieckmann
    Department of Dermatology, University of Erlangen-Nuremberg, Hartmannstrasse 14, 91052 Erlangen, Germany
    J Exp Med 193:1303-10. 2001
    ..The identification of regulatory CD4(+)CD25(+) T cells has important implications for the study of tolerance in man, notably in the context of autoimmunity, transplantation, and cancer...
  97. ncbi CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women
    Tsung Hsien Su
    Department of Gynecology and Obstetrics, Mackay Memorial Hospital, Tamshui, Taipei, Taiwan
    Carcinogenesis 28:1237-40. 2007
    ..Our results suggest that the -318 C/T variant in the promoter region of the CTLA-4 gene is associated with HPV-16-associated CSCC in Taiwanese women...
  98. pmc The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    Mohammed Javeed I Ansari
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 198:63-9. 2003
    ....
  99. ncbi Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice
    M B Mokyr
    Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, 60612, USA
    Cancer Res 58:5301-4. 1998
    ..These results suggest that the therapeutic benefits of CTLA-4 blockade depend on the ability of drugs such as melphalan to promote an immunogenic environment by altering the cytokine profile of tumor-specific T cells...
  100. pmc Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    R P Sutmuller
    Department of Immunohematology and Blood Transfusion, Tumor Immunology Lab, E3-Q, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Exp Med 194:823-32. 2001
    ..Simultaneous intervention with both regulatory mechanisms is therefore a promising concept for the induction of therapeutic antitumor immunity...
  101. ncbi CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population
    Antonio Petrone
    Department of Clinical Science, University of Rome La Sapienza, 00161 Rome, Italy
    Thyroid 15:232-8. 2005
    ..Inside the CTLA-4 region, CT60 appears to be the most associated polymorphism to GD, however, further studies are needed to identify the etiologic variant...

Research Grants64

  1. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..clinical tool used for diagnosis of hematopoietic malignancies based on measuring the levels of differentiation antigens. One model for the genesis of acute myeloid leukemia (AML) is that at least two mutations are ..
  2. Autoimmunity and anti tumor immunity outside of the melanocyte/melanoma paradigm
    Richard G Vile; Fiscal Year: 2012
    ..However, since many melanoma antigens are also normal melanocyte differentiation antigens, anti-melanoma immunity is often accompanied by autoimmunity...
  3. Targeting HSP70 in autoimmune vitiligo
    ISABELLE CAROLINE LE POOLE; Fiscal Year: 2012
    ..with focal infiltrates of CD8+ cytotoxic lymphocytes reactive, at least in part, with melanocyte differentiation antigens. In melanoma, a similar T cell mediated immune response targeting melanocyte differentiation antigens is ..
  4. Redirecting T Cell Responses to Self/Tumor Antigens Using Enforced Costimulation
    Anthony T Vella; Fiscal Year: 2013
    ..often harbor clonally expanded populations of anergic CD8 T cells specific for tissue/tumor- associated differentiation antigens. Our model thus represents a unique opportunity to understand and overcome this stubborn barrier to tumor ..
  5. IMMUNIZATION AGAINST MELANOMA DIFFERENTIATION ANTIGENS
    Jedd D Wolchok; Fiscal Year: 2013
    ..The overall goal of this grant is to develop more effective strategies to use the immune system to recognize specific targets present on melanoma cells. ..
  6. Polymer Based Gene Delivery
    Alexander V Kabanov; Fiscal Year: 2010
    ..activating signal transduction pathways;(4) evaluate Pluronic-formulated DNA vaccines expressing melanoma differentiation antigens and GM-CSF as an immune adjuvant in a mouse melanoma model...
  7. Exploring synergy of combined BRAF-targeted therapy &immunotherapy for melanoma
    Jennifer A Wargo; Fiscal Year: 2013
    ..BRAF (present in 60% of melanomas) may contribute to immune escape through suppression of melanocyte differentiation antigens and increased production of immunosuppressive cytokines...
  8. STRUCTURE AND REGULATION OF THE CD1 MULTIGENE FAMILY
    PAUL BLEICHER; Fiscal Year: 1992
    ..After entering the thymus, developing T cells express a sequence of differentiation antigens. The CD1 family of proteins is expressed on the surface of T cells only during their intrathymic ..
  9. Autoimmune vitiligo as a roadmap to melanoma therapy
    ISABELLE LE POOLE; Fiscal Year: 2007
    In autoimmune vitiligo, melanocytes are destroyed by cytotoxic T cells that recognize melanocyte differentiation antigens including MART-1 and gp100. This leads to progressive depigmentation of the skin and hair...
  10. REPLICATION OF HCMV IN HUMAN TERATOCARCINOMA CELLS
    Peter Andrews; Fiscal Year: 1992
    ..biochemical and genetic basis of SSEA-1 induction by HCMV, as well as changes in the expression of other differentiation antigens. We shall use transfection with cloned fragments of the HCMV genome of identify the part of the viral ..
  11. Targeted antigen receptor treatment of cancer
    David Scheinberg; Fiscal Year: 2009
    ..Shared themes include targeting differentiation antigens and tumor stroma, specificity of antigen receptors, enhancement of potency of antigen receptor-based ..
  12. NEW MODALITIES FOR ACTIVE IMMUNOTHERAPY OF MALIGNANCIES
    Thomas Kipps; Fiscal Year: 1993
    ..B cell malignancies express tissue-specific differentiation antigens that, as is the case for Ig, may have B cell- subset-specific or tumor cell-specific antigenic ..
  13. STRUCTURE-FUNCTION OF ADP-RIBOSYL CYCLASE AND HOMOLOGS
    HONCHEUNG LEE; Fiscal Year: 2003
    ..The other members of the family include the differentiation antigens CD38 (on lymphocytes) and BST1/BP3 (on bone marrow cells)...
  14. IMMUNOLOGIC THERAPY OF PROSTATE CANCER
    Gurkamal Chatta; Fiscal Year: 2001
    ..A major theoretical problem with targeting T cell therapy against differentiation antigens is that eliciting or boosting such immunity can result in destructive autoimmunity...
  15. MECHANISMS OF RETROVIRUS-INDUCED NEURAL DYSFUNCTION
    Steven Dow; Fiscal Year: 1993
    ..in cell function will include immunocytochemical identification of altered expression of cell surface and differentiation antigens in infected glial cells, morphologic studies of survival and outgrowth characteristics of neurons, and ..
  16. Optimizing T cell Immunity to Cancer Vaccines
    Miguel Angel Perales; Fiscal Year: 2006
    ..unreadable] [unreadable] Research will focus on the generation of T cell memory responses to melanoma differentiation antigens in a mouse pre-clinical model...
  17. A PILOT PHASE IB TRIAL OF A PSA PEPTIDE VACCINE
    David Peace; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Description) Prostate cancers express tissue-specific differentiation antigens that might be able to target highly selective autoimmune T cell immune responses with the ability to eliminate malignantly ..
  18. TLR/BCR Synergy in an Autoreactive B Cell Activation
    Ann Marshak Rothstein; Fiscal Year: 2003
    ..engagement with regard to parameters such as lipid raft formation, expression of specific cell surface differentiation antigens, antibody and cytokine production, sensitivity to pro-apoptotic effects of Fas-ligand, sensitivity to ..
  19. SPECIFIC IMMUNOTHERAPY OF MURINE TUMORS
    MARTIN CHEEVER; Fiscal Year: 2002
    ..This application proposes to determine whether polymorphic segments of abundant hematopoietic differentiation antigens can serve as GVL targets...
  20. DEVELOPMENT OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES
    Irving Goldschneider; Fiscal Year: 1990
    ..the use of the fluorescence-activated cell sorter in concert with antisera to a variety of cell surface differentiation antigens. Additionally we plan a series of experiments on B cell ontogeny, based on observation that in the rat ..
  21. BIOLOGY OF THE BONE MARROW DERIVED 3A1 STEM CELL
    Russell Ware; Fiscal Year: 1991
    ..Emphasis will be placed on T cell differentiation antigens and clonal analysis of hematopoietic progenitor cells...
  22. MECHANISMS OF OSTEOBLAST ACTIVATION AND DIFFERENTIATION
    Mark Horowitz; Fiscal Year: 2000
    ..in vitro; (5) cyclic AMP production in response to parathyroid hormone; (6) expression of cell surface differentiation antigens; and (7) secretion of, and regulation by osteotropic factors...
  23. DIFFERENTIATION OF MEMORY B CELL PRECURSORS
    JOHN FIDLER; Fiscal Year: 1980
    ..Immunoglobulin isotype, differentiation antigens, and nonimmunoglobulin surface receptors will also be used to characterize the memory B cell precursor...
  24. CELL PHENOTYPE AS A SURROGATE MARKER IN PEDIATRIC AIDS
    Susan Plaeger; Fiscal Year: 1990
    ..The study is designed to test the hypothesis that expression of cell surface activation and differentiation antigens on CD4 and Cd8 cells directly reflects the effects of HIV on the developing immune system of infected ..
  25. INTRACELLULAR CALCIUM REGULATION IN ALZHEIMER'S DISEASE
    ANGELIKA GROSSMAN; Fiscal Year: 1991
    ..In addition, the newly described calcium signa s produced by antibody crosslinking, of other differentiation antigens will b assessed...
  26. STRUCTURAL/FUNCTION B CELL DIFFERENTIATION ANTIGENS
    Edward Clark; Fiscal Year: 2007
    ..These studies will provide new insights into the mechanisms, which regulate the survival of normal B cells, malignant B cells and B cells contributing to autoimmune diseases ..
  27. INHIBITORS OF GLYCOSYLTRANSFERASES
    Ole Hindsgaul; Fiscal Year: 1991
    ..The new carbohydrate structures that appear during these processes are referred to as differentiation antigens or tumor-associated antigens...
  28. PROLIFERATION AND FUNCTION OF MONONUCLEAR PHAGOCYTES
    Carleton Stewart; Fiscal Year: 1991
    ..We will approach this objective by using currently available antibodies to differentiation antigens to identify and sort, using flow cytometry, cells at unique differentiation stages...
  29. DIFFERENTIATION ANTIGENS OF HUMAN PANCREATIC TUMORS
    Richard Metzgar; Fiscal Year: 1990
    ....
  30. REGULATION OF IGA RESPONSES IN LPSN AND LPSD MICE
    Hiroshi Kiyono; Fiscal Year: 1991
    ..for maturation markers including surface immunoglobulin (sIg), I-A, complement receptor (CR), and Lyb differentiation antigens. GF mice, which have been shown to exhibit immature B cell subpopulations, will be induced to maturation ..
  31. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
  32. Regulation of human T cell activation by the CD28 family
    James Riley; Fiscal Year: 2008
    ..The data generated from these studies will better define the relationship between antigen dependent and independent signals and enable new strategies to modulate T cell activation for therapeutic applications. ..
  33. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  34. Lentiviral Redirected T Cells for B Cancer Immunotherapy
    James Riley; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. Identifying and Analyzing Genes Linked to Autoimmune Thyroid Diseases
    Yaron Tomer; Fiscal Year: 2010
    ..This could have a major impact on public health, as it may facilitate the development of mechanism-based treatments in autoimmunity, such as CD40 blockade. ..
  36. Development of tumor based antigen presenting cells
    James Riley; Fiscal Year: 2008
    ..Furthermore, these studies will provide the foundation for conducting a clinical trial. ..
  37. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  38. Expansion of HIV infected T cells for immunotherapy
    James Riley; Fiscal Year: 2005
    ..Successful completion of these aims will pave the way for second generation autologous transfusion trials in which the ability of selected subsets of expanded T cells to fight opportunistic and HIV infection(s) can be measured. ..
  39. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
    ..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
  40. MyD118, CR6 and GADD45 in Genotoxic Stress
    Dan Liebermann; Fiscal Year: 2003
    ....
  41. CTLA-4 Inhibition and Autoimmunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2008
    ..abstract_text> ..
  42. MECHANISMS OF DONOR SPLEEN INDUCED TRANSPLANT TOLERANCE
    Daniel Goldstein; Fiscal Year: 2004
    ..The career development program, mentor and didactic courses are designed to allow Dr. Goldstein to become an independent investigator by the end of the award period. ..
  43. 2007 Cell-Cell Fusion
    AGNES VIGNERY; Fiscal Year: 2007
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function, which is to stimulate creativity and interaction in an emerging field of biology. [unreadable] [unreadable] [unreadable]..
  44. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  45. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  46. Role of Innate Immunity in Transplantation Tolerance
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
    ..g., MyD88 blockade at the time of tolerance induction). ..