lutein

Summary

Summary: A carotenoid alcohol widespread in nature. It is present in egg yolk, algae, and petals of yellow flowers, among other sources.

Top Publications

  1. ncbi The role of the xanthophyll cycle and of lutein in photoprotection of photosystem II
    Peter Jahns
    Plant Biochemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Biochim Biophys Acta 1817:182-93. 2012
  2. ncbi Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    Stuart Richer
    Department of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064 3095, USA
    Optometry 75:216-30. 2004
  3. ncbi Lutein: more than just a filter for blue light
    Aize Kijlstra
    University Eye Clinic Maastricht, Maastricht, The Netherlands
    Prog Retin Eye Res 31:303-15. 2012
  4. ncbi Supplementation with all three macular carotenoids: response, stability, and safety
    Eithne E Connolly
    Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Invest Ophthalmol Vis Sci 52:9207-17. 2011
  5. ncbi Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration
    Günther Weigert
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 52:8174-8. 2011
  6. pmc Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells
    Shasha Gao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:3180-90. 2011
  7. pmc Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes
    M Sasaki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetologia 53:971-9. 2010
  8. ncbi Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis
    Le Ma
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, People s Republic of China
    Br J Nutr 107:350-9. 2012
  9. ncbi Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye
    Norman I Krinsky
    Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
    Annu Rev Nutr 23:171-201. 2003
  10. ncbi Lutein, zeaxanthin, and the macular pigment
    J T Landrum
    Department of Chemistry, Florida International University, Miami 33199, USA
    Arch Biochem Biophys 385:28-40. 2001

Research Grants

Detail Information

Publications267 found, 100 shown here

  1. ncbi The role of the xanthophyll cycle and of lutein in photoprotection of photosystem II
    Peter Jahns
    Plant Biochemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Biochim Biophys Acta 1817:182-93. 2012
    ..role of the xanthophylls zeaxanthin (which is formed in the light in the so-called xanthophyll cycle) and lutein with emphasis on the NPQ processes associated with PSII of higher plants...
  2. ncbi Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    Stuart Richer
    Department of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064 3095, USA
    Optometry 75:216-30. 2004
    ..The objective of the lutein antioxidant supplementation trial (LAST) is to determine whether nutritional supplementation with lutein or lutein ..
  3. ncbi Lutein: more than just a filter for blue light
    Aize Kijlstra
    University Eye Clinic Maastricht, Maastricht, The Netherlands
    Prog Retin Eye Res 31:303-15. 2012
    b>Lutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties...
  4. ncbi Supplementation with all three macular carotenoids: response, stability, and safety
    Eithne E Connolly
    Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Invest Ophthalmol Vis Sci 52:9207-17. 2011
    This study was designed to investigate serum and macular response to, and safety of supplementation with, meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z), the carotenoids that constitute macular pigment (MP).
  5. ncbi Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration
    Günther Weigert
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 52:8174-8. 2011
    There is evidence from several large-scale clinical trials that reduced intake of lutein, a major component of the macular pigment, is a risk factor for the development of AMD...
  6. pmc Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells
    Shasha Gao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:3180-90. 2011
    Epidemiological studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract...
  7. pmc Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes
    M Sasaki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetologia 53:971-9. 2010
    ..Here, we focused on oxidative stress in the retina, and analysed its influence on retinal neurodegeneration, using an antioxidant, lutein.
  8. ncbi Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis
    Le Ma
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, People s Republic of China
    Br J Nutr 107:350-9. 2012
    b>Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent...
  9. ncbi Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye
    Norman I Krinsky
    Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
    Annu Rev Nutr 23:171-201. 2003
    ..retina is yellow in color due to the presence of the macular pigment, composed of two dietary xanthophylls, lutein and zeaxanthin, and another xanthophyll, meso-zeaxanthin...
  10. ncbi Lutein, zeaxanthin, and the macular pigment
    J T Landrum
    Department of Chemistry, Florida International University, Miami 33199, USA
    Arch Biochem Biophys 385:28-40. 2001
    The predominant carotenoids of the macular pigment are lutein, zeaxanthin, and meso-zeaxanthin...
  11. pmc Identification of StARD3 as a lutein-binding protein in the macula of the primate retina
    Binxing Li
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
    Biochemistry 50:2541-9. 2011
    b>Lutein, zeaxanthin, and their metabolites are the xanthophyll carotenoids that form the macular pigment of the human retina...
  12. pmc The relation between serum lipids and lutein and zeaxanthin in the serum and retina: results from cross-sectional, case-control and case study designs
    Lisa M Renzi
    Human Biofactors Laboratory and Vision Sciences Laboratory, The University of Georgia, 601 Psychology Building, Athens, GA 30602 3013, USA
    Lipids Health Dis 11:33. 2012
    The xanthophyll carotenoids lutein (L) and zeaxanthin (Z) are found in and around the macula of the primate retina, where they are termed macular pigment (MP)...
  13. ncbi Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 11:75-83. 2008
    Low dietary intake of docosahexaenoic acid (DHA) and/or foods rich in lutein may be associated with increased risk of cognitive decline in the elderly.
  14. ncbi The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22
    John Paul SanGiovanni
    The EMMES Corporation, 401 N Washington St, Ste 700, Rockville, MD 20850 1707, USA
    Arch Ophthalmol 125:1225-32. 2007
    ..To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)...
  15. ncbi Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study
    Cécile Delcourt
    Institut National de la Sante et de la Recherche Medicale INSERM, Research Unit U593 for Epidemiology, Public Health and Development, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Invest Ophthalmol Vis Sci 47:2329-35. 2006
    To assess the associations of plasma lutein and zeaxanthin and other carotenoids with the risk of age-related maculopathy (ARM) and cataract in the population-based Pathologies Oculaires Liées à l'Age (POLA) Study.
  16. pmc Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite
    Takashi Maoka
    Research Institute for Production Development, 15 Shimogamo Morimoto Cho, Sakyo ku, Kyoto 606 0805, Japan
    Mar Drugs 10:1391-9. 2012
    ..These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite.
  17. ncbi Nutritional and clinical relevance of lutein in human health
    F Granado
    Servicio de Endocrinologia y Nutricion, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Br J Nutr 90:487-502. 2003
    b>Lutein is one of the most widely found carotenoids distributed in fruits and vegetables frequently consumed. Its presence in human tissues is entirely of dietary origin...
  18. ncbi Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke
    Suk Yee Li
    Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Neurobiol Dis 45:624-32. 2012
    ..The aim of this study is to investigate the protective roles of lutein in cerebral I/R injury.
  19. ncbi Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study
    Meike Trieschmann
    Institute of Ophthalmology, St Franziskus Hospital, and Institute of Epidemiology, University of Munster, Germany
    Exp Eye Res 84:718-28. 2007
    Macular pigment (MP), consisting of lutein (L) and zeaxanthin (Z), is believed to protect the retina from photo-oxidative damage...
  20. ncbi A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration
    Sarah Sabour-Pickett
    Department of Optometry, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland
    Mol Nutr Food Res 56:270-86. 2012
    ..The dietary carotenoids, lutein (L), zeaxanthin (Z), and meso-zeaxanthin (meso-Z), accumulate at the macula, where they are collectively known as ..
  21. ncbi Distribution of lutein, zeaxanthin, and related geometrical isomers in fruit, vegetables, wheat, and pasta products
    Julia M Humphries
    Department of Plant Science, Waite Campus, The University of Adelaide, Australia
    J Agric Food Chem 51:1322-7. 2003
    Quantitative data with regard to dietary (3R,3'R,6'R)-lutein, (3R,3'R)-zeaxanthin, and their (E/Z)-geometrical isomers are scarce, and in most cases, only the combined concentrations of these two carotenoids in foods are reported...
  22. ncbi Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population
    J Curran-Celentano
    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, NH 03824, USA
    Am J Clin Nutr 74:796-802. 2001
    ..Information on concentrations of retinal carotenoids (macular pigment, or MP) is of particular interest because MP protects against age-related macular degeneration, the leading cause of irreversible blindness in the United States...
  23. ncbi Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina
    L M Rapp
    Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 41:1200-9. 2000
    ..The purpose of this study was to determine whether lutein and zeaxanthin, the major carotenoids comprising the macular pigment, are present in rod outer segment (ROS) ..
  24. pmc Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration
    Eunyoung Cho
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 87:1837-43. 2008
    The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness.
  25. ncbi Biotechnological production of lutein and its applications
    José M Fernández-Sevilla
    Department of Chemical Engineering, University of Almeria, La Canada de San Urbano, Almeria 04120, Spain
    Appl Microbiol Biotechnol 86:27-40. 2010
    b>Lutein is an antioxidant that has gathered increasing attention due to its potential role in preventing or ameliorating age-related macular degeneration...
  26. pmc Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A
    Eliot L Berson
    Berman Gund Laboratory for Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 128:403-11. 2010
    To determine whether lutein supplementation will slow visual function decline in patients with retinitis pigmentosa receiving vitamin A.
  27. ncbi Carotenoid actions and their relation to health and disease
    Norman I Krinsky
    Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
    Mol Aspects Med 26:459-516. 2005
    ..The carotenoids that have been most studied in this regard are beta-carotene, lycopene, lutein and zeaxanthin. In part, the beneficial effects of carotenoids are thought to be due to their role as antioxidants...
  28. ncbi The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation
    Ji Hee Kim
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    Free Radic Biol Med 45:885-96. 2008
    ..We found that the non-provitamin A carotenoid, lutein, decreased intracellular H(2)O(2) accumulation by scavenging superoxide and H(2)O(2) and the NF-kappaB-regulated ..
  29. ncbi Neuroprotective effect of an antioxidant, lutein, during retinal inflammation
    Mariko Sasaki
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:1433-9. 2009
    b>Lutein has been the focus of recent study as a possible therapeutic approach for retinal diseases, but the molecular mechanism of its neuroprotective effect remains to be elucidated...
  30. pmc Lutein is needed for efficient chlorophyll triplet quenching in the major LHCII antenna complex of higher plants and effective photoprotection in vivo under strong light
    Luca Dall'osto
    Dipartimento Scientifico e Tecnologico, Universita di Verona, Strada Le Grazie 15, I 37134 Verona, Italy
    BMC Plant Biol 6:32. 2006
    b>Lutein is the most abundant xanthophyll in the photosynthetic apparatus of higher plants. It binds to site L1 of all Lhc proteins, whose occupancy is indispensable for protein folding and quenching chlorophyll triplets...
  31. pmc Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein
    Jodi Bettler
    Wyeth, Collegeville, PA, USA
    Eur J Nutr 49:45-51. 2010
    b>Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula...
  32. ncbi Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid
    Ana J Chucair
    Instituto de Investigaciones Bioquímicas de Bahía Blanca INIBIBB and Universidad Nacional del Sur UNS, Bahia Blanca, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 48:5168-77. 2007
    ..b>Lutein (LUT) and zeaxanthin (ZEA), major components in macular pigment, are among the retinal antioxidants...
  33. ncbi Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration
    Stephen Beatty
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford City, Waterford, Republic of Ireland
    Ophthalmology 120:600-6. 2013
    ..To report the secondary outcomes in the Carotenoids with Coantioxidants in Age-Related Maculopathy trial...
  34. pmc Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) study
    Jessie A Satia
    Departments of Nutrition and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Epidemiol 169:815-28. 2009
    ..The authors examined associations of supplemental beta-carotene, retinol, vitamin A, lutein, and lycopene with lung cancer risk among participants, aged 50-76 years, in the VITamins And Lifestyle (VITAL) ..
  35. ncbi Comparison of macular pigment in patients with age-related macular degeneration and healthy control subjects - a study using spectral fundus reflectance
    Semira Kaya
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Acta Ophthalmol 90:e399-403. 2012
    ..In this study, we investigated the age dependence of MPOD using spectral fundus reflectance. In addition, we hypothesized that patients with AMD have a reduced MPOD as compared to healthy controls...
  36. ncbi Intake of lutein and zeaxanthin differ with age, sex, and ethnicity
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Am Diet Assoc 110:1357-62. 2010
    b>Lutein and zeaxanthin are carotenoids that are selectively taken up into the macula of the eye, where they may protect against development of age-related macular degeneration...
  37. ncbi Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta)
    Kuzhuvelil Bhaskarannair Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Int J Toxicol 27:1-9. 2008
    b>Lutein is a carotenoid with antioxidant properties and is commonly present in many fruits, vegetables, and egg yolk...
  38. pmc Neuroprotective effects of lutein in the retina
    Yoko Ozawa
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Curr Pharm Des 18:51-6. 2012
    ..In this review, we focus on lutein, which is a xanthophyll type of carotenoid...
  39. ncbi A central dip in the macular pigment spatial profile is associated with age and smoking
    Mark L Kirby
    Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Invest Ophthalmol Vis Sci 51:6722-8. 2010
    ..To investigate the relationship between specific macular pigment (MP) spatial profiles and risk factors for age-related macular degeneration (AMD)...
  40. ncbi Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study
    Eithne E Connolly
    Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Curr Eye Res 35:335-51. 2010
    At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation.
  41. ncbi Macular pigment optical density in an ageing Irish population: The Irish Longitudinal Study on Ageing
    John M Nolan
    Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, and Institute of Vision Research, Whitfield Clinic, Waterford, Ireland jmnolan wit ie
    Ophthalmic Res 44:131-9. 2010
    The 3 carotenoids lutein, zeaxanthin, and meso-zeaxanthin, which account for the 'yellow spot' at the macula and which are referred to as macular pigment (MP), are believed to play a role in visual function and protect against age-related ..
  42. ncbi The relation between the macular carotenoids, lutein and zeaxanthin, and temporal vision
    Lisa M Renzi
    Institute for Neuroscience and Center for Perceptual Systems, University of Texas at Austin, Austin, TX, USA
    Ophthalmic Physiol Opt 30:351-7. 2010
    b>Lutein (L) and zeaxanthin (Z) are the dominant carotenoids within the central retina (there, termed macular pigment, MP) and brain (approximately 70% of total carotenoid concentration)...
  43. ncbi The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS
    John M Nolan
    Macular Pigment Research Group, Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
    Vision Res 51:459-69. 2011
    ..121 normal subjects were recruited. The active (A) group consumed 12 mg of lutein (L) and 1mg of zeaxanthin (Z) daily...
  44. pmc A naturally occurring carotenoid, lutein, reduces PDGF and H₂O₂ signaling and compromised migration in cultured vascular smooth muscle cells
    Huey Ming Lo
    Section of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 19:18. 2012
    ..In this study we examined the effect of the other naturally occurring carotenoid, lutein, on PDGF signaling and migration in VSMCs.
  45. pmc Inverse association of vitamin C with cataract in older people in India
    Ravilla D Ravindran
    Aravind Eye Hospital Pondicherry, Aravind Eye Care, Pondicherry, India
    Ophthalmology 118:1958-1965.e2. 2011
    ..To examine the association between vitamin C and cataract in the Indian setting...
  46. ncbi Obesity, lutein metabolism, and age-related macular degeneration: a web of connections
    Elizabeth J Johnson
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr Rev 63:9-15. 2005
    ..Currently there is no effective cure for this disease. Risk factors include decreased lutein and zeaxanthin status and obesity. Obesity is also an increasing public health concern...
  47. ncbi Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial
    Le Ma
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China
    Am J Ophthalmol 154:625-634.e1. 2012
    To examine the effects of lutein and zeaxanthin supplementation on retinal function using multifocal electroretinograms (mfERG) in patients with early age-related macular degeneration (AMD).
  48. pmc Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells
    Qingning Bian
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 53:1298-307. 2012
    ..Epidemiologic studies suggest that insufficient dietary lutein and zeaxanthin intake or lower serum zeaxanthin levels are associated with increased risk for AMD...
  49. pmc Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health
    El Sayed M Abdel-Aal
    Guelph Food Research Centre, Agriculture and Agri Food Canada, Guelph, ON N1G 5C9, Canada
    Nutrients 5:1169-85. 2013
    ..Numerous studies have identified lutein and zeaxanthin to be essential components for eye health...
  50. pmc Synergistic interactions between carotene ring hydroxylases drive lutein formation in plant carotenoid biosynthesis
    Rena F Quinlan
    Department of Biological Sciences, Lehman College, City University of New York, Bronx, New York 10468, USA
    Plant Physiol 160:204-14. 2012
    ..The formation of lutein, which involves hydroxylation of both β- and ε-rings, was shown to require the coexpression of CYP97A and CYP97C ..
  51. ncbi Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance
    Khalil Mitri
    Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universitat Berlin, Institute of Pharmacy, Kelchstr 31, 12169 Berlin, Germany
    Int J Pharm 414:267-75. 2011
    Topical application of lutein as an innovative antioxidant, anti-stress and blue light filter, which is able to protect skin from photo damage, has got a special cosmetic and pharmaceutical interest in the last decade...
  52. ncbi Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish population
    Jouni Karppi
    Department of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Br J Nutr 108:148-54. 2012
    ..Previous studies have shown that long-term dietary intake of antioxidants (lutein and zeaxanthin) may decrease the risk of age-related cataracts...
  53. ncbi Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration
    Le Ma
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China
    Ophthalmology 119:2290-7. 2012
    To determine whether supplementation with lutein and zeaxanthin improves macular pigment and visual function in patients with early age-related macular degeneration (AMD).
  54. ncbi Safety assessment of lutein and zeaxanthin (Lutemax 2020): subchronic toxicity and mutagenicity studies
    R Ravikrishnan
    RCC Laboratories India Pvt Ltd, Genome Valley, Shameerpet, Hyderabad 500 078, AP, India
    Food Chem Toxicol 49:2841-8. 2011
    b>Lutein and zeaxanthin, naturally occurring carotenoids, have shown to reduce the risk of cataracts and age-related macular degeneration...
  55. pmc Reactive oxygen species and transcript analysis upon excess light treatment in wild-type Arabidopsis thaliana vs a photosensitive mutant lacking zeaxanthin and lutein
    Alessandro Alboresi
    Dipartimento di Biotecnologie, Universita di Verona, Strada Le Grazie 15, Verona, Italy
    BMC Plant Biol 11:62. 2011
    ..Despite their destructive activity they are also signalling molecules, priming the acclimatory response to stress stimuli...
  56. ncbi Influence of lutein supplementation on macular pigment, assessed with two objective techniques
    T T Berendschot
    University Medical Centre Utrecht, Department of Ophthalmology, The Netherlands
    Invest Ophthalmol Vis Sci 41:3322-6. 2000
    ..This study was conducted to determine the extent of changes in the macular pigment density as a consequence of oral supplementation with lutein. A second purpose was to compare two objective measurement techniques.
  57. ncbi CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures
    Myriam Moussa
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Mol Nutr Food Res 55:578-84. 2011
    ..However, nothing is known regarding the uptake of carotenoids by adipocytes. Thus, our study explored the mechanism by which lycopene and lutein, two major human plasma carotenoids, are transported.
  58. pmc Enhancement of lutein production in Chlorella sorokiniana (Chorophyta) by improvement of culture conditions and random mutagenesis
    Baldo F Cordero
    Institute of Plant Biochemistry and Photosynthesis, CIC Cartuja, University of Seville and CSIC, Spain
    Mar Drugs 9:1607-24. 2011
    Chlorella sorokiniana has been selected for lutein production, after a screening of thirteen species of microalgae, since it showed both a high content in this carotenoid and a high growth rate...
  59. ncbi Macular pigment in donor eyes with and without AMD: a case-control study
    R A Bone
    Department of Physics, Florida International University, Miami, Florida 33199, USA
    Invest Ophthalmol Vis Sci 42:235-40. 2001
    ..To determine whether there is an association between the density of macular pigment in the human retina and the risk of age-related macular degeneration (AMD)...
  60. pmc The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)
    Emily Y Chew
    Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 119:2282-9. 2012
    ..The primary purpose of the Age-Related Eye Disease Study 2 (AREDS2) is to evaluate the efficacy and safety of lutein plus zeaxanthin (L+Z) and/or ω-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation in reducing the ..
  61. ncbi Lutein and zeaxanthin and their potential roles in disease prevention
    Judy D Ribaya-Mercado
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Am Coll Nutr 23:567S-587S. 2004
    b>Lutein and zeaxanthin are xanthophyll carotenoids found particularly in dark-green leafy vegetables and in egg yolks...
  62. ncbi Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidants
    S P Sundelin
    Division of Ophthalmology, Department of Neuroscience and Locomotion, Linkoping University, Linkoping, Sweden
    Free Radic Biol Med 31:217-25. 2001
    ..support of this idea, we now report significantly reduced formation of lipofuscin when the antioxidant substances lutein, zeaxanthin, lycopene (carotenoids), or alpha-tocopherol were added to rabbit and bovine (calf) retinal pigment ..
  63. pmc Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, and Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02111, USA
    Mol Vis 16:2412-24. 2010
    ..We evaluated its association and interaction with previously identified genetic variants and modifiable factors...
  64. ncbi Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment
    Benedetto Falsini
    Istituto di Oftalmologia, Universita Cattolica del S Cuore, Rome, Italy
    Ophthalmology 110:51-60; discussion 61. 2003
    ..To evaluate the influence of short-term antioxidant supplementation on retinal function in age-related maculopathy (ARM) patients by recording focal electroretinograms (FERGs)...
  65. ncbi Photoprotection in the antenna complexes of photosystem II: role of individual xanthophylls in chlorophyll triplet quenching
    Milena Mozzo
    Department of Biophysical Chemistry, Groningen Bimolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
    J Biol Chem 283:6184-92. 2008
    ..The largest part of the triplets is quenched by the lutein bound in site L1, which is located in close proximity to the chlorophylls responsible for the low energy state of ..
  66. ncbi Associations between lutein, zeaxanthin, and age-related macular degeneration: an overview
    Shannon Carpentier
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Rev Food Sci Nutr 49:313-26. 2009
    ..b>Lutein and zeaxanthin are macular pigments that may play a role in reducing the development and progression of age-..
  67. ncbi Long-term nutrient intake and early age-related nuclear lens opacities
    P F Jacques
    Laboratory for Nutrition and Vision, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arch Ophthalmol 119:1009-19. 2001
    ..001), vitamin E (P =.02), riboflavin (P =.005), folate (P =.009), beta-carotene (P =.04), and lutein/zeaxanthin (P =.03)...
  68. pmc Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative
    Suzen M Moeller
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726 2336, USA
    Arch Ophthalmol 126:354-64. 2008
    To evaluate associations between nuclear cataract (determined from slitlamp photographs between May 2001 and January 2004) and lutein and zeaxanthin in the diet and serum in patients between 1994 and 1998 and macula between 2001 and 2004.
  69. ncbi Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression
    Rajashree Krishnaswamy
    School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore 641046, India
    Free Radic Biol Med 49:50-60. 2010
    ..In the present study, the cytoprotective effect of lutein, was tested in HT-29 cells against DON-induced oxidative stress and cytotoxicity...
  70. ncbi β-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-κB and IL-8 expression in gastric epithelial AGS cells
    Youngha Kim
    Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, Korea
    J Nutr Sci Vitaminol (Tokyo) 57:216-23. 2011
    ..Low intake of β-carotene leads to high risk of gastric cancer. Oxygenated carotenoid lutein inhibited NF-κB activation in experimental uveitis...
  71. ncbi Lutein and zeaxanthin in eye and skin health
    Richard L Roberts
    Kemin Health, LC, 600 E Court Avenue, Suite A, Des Moines, IA 50309 2058, USA
    Clin Dermatol 27:195-201. 2009
    ..The body does not synthesize them. Among the carotenoids present in the body, only lutein and its coexistent isomer, zeaxanthin, are found in that portion of the eye where light is focused by the lens, ..
  72. ncbi Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study
    J H Dwyer
    Department of Preventive Medicine, Institute for Prevention Research, Keck School of Medicine, University of Southern California, USA
    Circulation 103:2922-7. 2001
    ..The present study assessed the protective effects of the oxygenated carotenoid lutein against early atherosclerosis.
  73. ncbi Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 27:2555-62. 2007
    ..The aim of the current study was to investigate the effect of lutein supplementation on the development of the murine model of laser-induced CNV together with underlying molecular ..
  74. pmc Arabidopsis carotenoid mutants demonstrate that lutein is not essential for photosynthesis in higher plants
    B Pogson
    Department of Plant Sciences, University of Arizona, Tucson 85721, USA
    Plant Cell 8:1627-39. 1996
    b>Lutein, a dihydroxy beta, epsilon-carotenoid, is the predominant carotenoid in photosynthetic plant tissue and plays a critical role in light-harvesting complex assembly and function...
  75. ncbi The evolution and function of carotenoid hydroxylases in Arabidopsis
    Joonyul Kim
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    Plant Cell Physiol 50:463-79. 2009
    ..Surprisingly, triple mutants containing only CYP97C1 or CYP97A3 activity produced 74 and 6% of the wild-type lutein level, indicating that CYP97C1 can efficiently hydroxylate both the beta- and epsilon-rings of alpha-carotene and ..
  76. ncbi Macular pigment density and aging, assessed in the normal elderly and those with cataracts and age-related macular degeneration
    Thomas A Ciulla
    Retina Service, Midwest Eye Institute, Methodist Medical Plaza North, Indianapolis, Indiana 46280, USA
    Am J Ophthalmol 138:582-7. 2004
    Increasing evidence has linked retinal lutein and zeaxanthin (termed macular pigment, MP) to the risk of age-related macular degeneration (AMD)...
  77. pmc Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells
    Nilesh M Kalariya
    AMD Center, Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1106, USA
    Curr Eye Res 34:737-47. 2009
    To investigate the genotoxic effects of lutein (LBP) and beta -carotene breakdown products (beta -apo-8-carotenal, BA8C) and the preventive role of GSH in human retinal pigment epithelial cells (ARPE-19).
  78. ncbi [Lutein and antioxidants in the prevention of age-related macular degeneration]
    M Rehak
    Klinik und Poliklinik für Augenheilkunde, Universitat Leipzig, Leipzig, Deutschland
    Ophthalmologe 105:37-8, 40-5. 2008
    ..The macular pigment consists mostly of lutein and zeaxanthin...
  79. ncbi Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin
    Wendy M R Broekmans
    TNO Nutrition and Food Research, Zeist, Netherlands
    Am J Clin Nutr 76:595-603. 2002
    Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration...
  80. ncbi Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study
    Wolfgang Schalch
    DSM Nutritional Products Ltd, NRD CH, Building 203 855, Wurmisweg 576, CH 4303, Kaiseraugst, Switzerland
    Arch Biochem Biophys 458:128-35. 2007
    The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea...
  81. ncbi Lutein supplementation alters inflammatory cytokine production and antioxidant status in F-line turkeys
    R Shanmugasundaram
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, Wooster, OH, USA
    Poult Sci 90:971-6. 2011
    Effect of dietary lutein supplementation on turkey production parameters, cytokine production, and oxidative status during an acute phase response following lipopolysaccharide (LPS) injection was studied...
  82. ncbi Macular pigment: quantitative analysis on autofluorescence images
    M Trieschmann
    Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring 74, 48145 Münster, Germany
    Graefes Arch Clin Exp Ophthalmol 241:1006-12. 2003
    ..In the present study a quantification analysis of MP in AF images was developed to verify these MP types and to compare MP distribution patterns between healthy individuals and those with age-related macular degeneration (AMD)...
  83. ncbi Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin
    Stephen Beatty
    Macular Pigment Laboratory, Waterford Institute of Technology, Cork Road, Waterford, Ireland
    Arch Biochem Biophys 430:70-6. 2004
    ..b>Lutein (L) and zeaxanthin (Z) are two hydroxy-carotenoids with antioxidant activity which accumulate at the macula, where ..
  84. ncbi A lutein-enriched diet prevents cholesterol accumulation and decreases oxidized LDL and inflammatory cytokines in the aorta of guinea pigs
    Jung Eun Kim
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 141:1458-63. 2011
    b>Lutein has been shown to be protective against age-related macular degeneration; however, the antiinflammatory and antioxidant effects of this carotenoid in aortas are less known. Guinea pigs were fed a hypercholesterolemic diet (0...
  85. ncbi The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter
    William E Connor
    Division of Endocrinology, Metabolism, and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 48:4226-31. 2007
    b>Lutein and zeaxanthin are largely transported in plasma by high-density lipoprotein (HDL)...
  86. ncbi Serum carotenoids and oxidative DNA damage in human lymphocytes
    A R Collins
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    Carcinogenesis 19:2159-62. 1998
    ..pyrimidines and altered purines in the DNA of lymphocytes from volunteers supplemented with alpha/beta-carotene, lutein, lycopene or placebo...
  87. ncbi Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans
    Richard A Bone
    Department of Physics, Florida International University, Miami 33199, USA
    J Nutr 133:992-8. 2003
    ..Increased risk of AMD may result from low levels of lutein and zeaxanthin (macular pigment) in the diet, serum or retina, and excessive exposure to blue light...
  88. ncbi Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory response
    Ramesh K Selvaraj
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    Comp Biochem Physiol A Mol Integr Physiol 157:198-203. 2010
    This study investigated the effects of dietary lutein and polyunsaturated fatty acids (PUFA) on the total lutein and lipid levels, the peroxisome proliferators activated receptors (PPAR) alpha and gamma, retinoic acid X receptor (RXR) ..
  89. ncbi Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats
    Xue Hai Jin
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 47:2562-8. 2006
    b>Lutein deposits in the macula and lens of human eyes with high concentration and is well known as an eye-protective nutrient for its beneficial effects on eye disease such as age-related macular degeneration and cataract...
  90. ncbi Alternative splicing, activation of cryptic exons and amino acid substitutions in carotenoid biosynthetic genes are associated with lutein accumulation in wheat endosperm
    Crispin A Howitt
    CSIRO Food Futures National Research Flagship, Canberra, Australia
    Funct Integr Genomics 9:363-76. 2009
    ..epsilon-LCY) and phytoene synthase (Psy-A1), were identified as candidate genes for two of the QTL affecting lutein content in wheat endosperm...
  91. ncbi [Effect of lutein on relieving oxidative stress in mice induced by D-galatose]
    Jiayi Mai
    Department of Nutrition and Food Hygiene, School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China
    Wei Sheng Yan Jiu 39:430-2. 2010
    To study the effect of lutein on relieving oxidative stress in the liver of mice induced by D-galactose(D-gal).
  92. ncbi Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients
    Nicolas Cardinault
    Unité des Maladies Métaboliques et Micronutriments, INRA Clermont Ferrand Theix, 63122 St Genes Champanelle, France
    Clin Chim Acta 357:34-42. 2005
    ..The aim of this study was to determine carotenoid levels in serum and in different lipoprotein fractions in patients diagnosed for ARMD and in matched control group...
  93. ncbi Absorption and metabolism of dietary carotenoids
    Akihiko Nagao
    National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Biofactors 37:83-7. 2011
    ..carotenoids found in human tissues, however, are limited to several including such as β-carotene, lycopene, and lutein. We have little knowledge of whether carotenoids are selectively absorbed in intestine and metabolized ..
  94. pmc The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field
    John Paul SanGiovanni
    National Eye Institute, Clinical Trials Branch, Bethesda, MD 20892 1863, USA
    Am J Clin Nutr 96:1223S-33S. 2012
    ..In this article we review the history and state of science on the putative role of the MXs (lutein, zeaxanthin, and meso-zeaxanthin) in AMD and report findings on AMD-associated genes encoding enzymes, ..
  95. ncbi Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress
    Dong Wei
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China
    Sci China C Life Sci 51:1088-93. 2008
    ..has attracted interest as a promising organism for commercial production of a high-value carotenoid, lutein, by heterotrophic fermentation...
  96. ncbi Lutein prevents cataract development and progression in diabetic rats
    Emma Arnal
    Departamento de Fisiologia, Farmacología and Toxicología, Universidad CEU Cardenal Herrera, Avda Seminario s n, 46113 Moncada, Valencia, Spain
    Graefes Arch Clin Exp Ophthalmol 247:115-20. 2009
    ..It is often associated with complications, such as cataracts. Cataract, characterized by cloudiness or opacity of the eye lens, is the leading cause of blindness worldwide...
  97. ncbi Keto-carotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissues
    Lina Yonekura
    National Food Research Institute, NARO, Tsukuba, Ibaraki 305 8642, Japan
    J Nutr 140:1824-31. 2010
    ..the metabolism, tissue distribution, and depletion of fucoxanthin in ICR mice by comparison with those of lutein. The experiments comprised 14-d dietary supplementation with lutein esters or fucoxanthin, followed by 41- or 28-d,..
  98. ncbi Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta)
    J A Del Campo
    Instituto de Bioquimica Vegetal y Fotosintesis, Centro de Investigaciones Cientificas Isla de la Cartuja, Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Avda Americo Vespucio s n, 41092 Sevilla, Spain
    Appl Microbiol Biotechnol 64:848-54. 2004
    ..zofingiensis strain CCAP 211/14 accumulates a significant amount of valuable carotenoids, namely astaxanthin and lutein, of increasing demand for use as feed additives in fish and poultry farming, as colorants in food, and in health ..
  99. ncbi High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch culture
    Xian Ming Shi
    Key Laboratory of Microbiology of Agricultural Ministry, Huazhong Agricultural University, Wuhan 430070, P R China
    Biotechnol Prog 18:723-7. 2002
    ..Such a modification resulted in an enhanced lutein production without significantly lowering biomass production. The cellular lutein content was 0...
  100. ncbi Carotenoids from in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (Gallus gallus domesticus)
    Elizabeth A Koutsos
    Department of Animal Science, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Nutr 136:1027-31. 2006
    b>Lutein, a dihydroxycarotenoid, has antioxidant and immunomodulatory potential...
  101. ncbi Risk assessment for the carotenoids lutein and lycopene
    Andrew Shao
    Council for Responsible Nutrition, 1828 L St, NW, Suite 900, Washington, DC 20036 5114, USA
    Regul Toxicol Pharmacol 45:289-98. 2006
    b>Lutein and lycopene, two prevalent carotenoids in the human diet have become increasingly popular ingredients in dietary supplements...

Research Grants64

  1. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..that protect against oxidative stress ([unreadable]- and [unreadable]-carotene, cryptoxanthin, cysteine, folate, lutein, lycopene, oleic acid, pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group ..
  2. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lutein, zeaxanthin, and their metabolites are dietary xanthophyll carotenoids that are specifically concentrated in the macula lutea of the human eye where they are thought to provide protection ..
  3. Quantitation of In Vivo Human Lutein Metabolism
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lutein is an oxygenated carotenoid (xanthophyll) found in dark green leafy vegetables...
  4. Glutathione S-Transferase Pi in Age-Related Macular Degeneration
    Wen Hsiang Lee; Fiscal Year: 2013
    ..Concentrated in the human macula are dietary carotenoid antioxidants lutein and zeaxanthin, and their levels have been found to be lower in AMD compared to elderly control eyes...
  5. Diet and Lifestyle Factors Reducing Risk for Age-Related Eye Disease
    Julie A Mares; Fiscal Year: 2013
    ..We recently reported evidence to support protective roles of vitamin D, the macular carotenoids, lutein and zeaxanthin, healthy diet patterns and physical activity against the development of early/intermediate stages ..
  6. Age-Related Eye Disease Study 2 (AREDS2) Coordinating Center
    Traci Clemons; Fiscal Year: 2009
    Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD...
  7. Age-Related Eye Disease Study 2 (AREDS2) Coordinating Center
    Traci Clemons; Fiscal Year: 2010
    Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD...
  8. Age-Related Eye Disease Study 2 (AREDS2) Coordinating Center
    Traci Clemons; Fiscal Year: 2011
    Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD...
  9. CONTROL OF CORPUS LUTEUM FUNCTION
    John Gadsby; Fiscal Year: 1990
    ..PL will be used to test the presence of PL bioactivity during the isolation and purification process; granulosa lutein cells taken from corpora lutea taken on day 1 of pseudopregnancy will be dissociated with collagenase and ..
  10. FAT SOLUBLE MICRONUTRIENTS IN HUMAN PLASMA AND TISSUES
    NORMAN KRINSKY; Fiscal Year: 1993
    ..gamma-tocopherol and carotenoids such as beta- carotene, alpha-carotene, lycopene, alpha-and beta-cryptoxanthins, lutein, zeaxanthin and the more polar epoxycarotenoids, neoxanthin and violaxanthin...
  11. GENE-DIET INTERACTIONS AND HEART DISEASE
    HANNAI CAMPOS; Fiscal Year: 2003
    ..We will study whether high intakes of alpha-linolenic acid, vitamin E, carotene, particularly alpha- carotene, lutein, and lycopene reduce the risk of CHD, and whether the GDAS marker variants alleles lessen this protective effect...
  12. REPRODUCTIVE TOXICOLOGY AND EPIDEMIOLOGY
    Bill Lasley; Fiscal Year: 2003
    ..TCDD as a model compound to investigate the ovary and the placenta as major targets of toxicity to human granulosa lutein cells and human trophoblast cells...
  13. Effects of Antioxidants on Human Macular Pigments
    Kyung Jin Yeum; Fiscal Year: 2006
    ..Low dietary intake or low blood levels of lutein and zeaxanthin, which are the only pigments found in the macular region of the human retina, has been associated ..
  14. Plasma Markers of Dietry Intervention to Delay Cognitiv*
    JAE KANG; Fiscal Year: 2005
    ..we propose to prospectively examine plasma markers of a wide array of antioxidants (alpha-carotene, beta-carotene, lutein/zeaxanthin, lycopene, beta-cryptoxanthin, alpha-tocopherol and gamma-tocopherol) and homocysteine, folate and ..
  15. EFFECTS OF LUTEIN IN RETINITIS PIGMENTOSA
    Gislin Dagnelie; Fiscal Year: 2001
    ..a recent patient-initiated pilot study demonstrated that RP patients may respond to a nutrition supplement (lutein) with a modest, but statistically significant gain in visual acuity and central visual field area; demonstrating ..
  16. MACULAR BIOCHEMISTRY
    ALICE ADLER; Fiscal Year: 1999
    ..Aims are to answer the following questions: l) What is the mechanism by which the macular-pigment carotenoids, lutein and zeaxanthin, shown to be protective against AMD, are selectively accumulated in the foveal region of the ..
  17. XANTHOPHYLL-MEDIATED RETINAL DRUG DELIVERY
    Dennis Marcus; Fiscal Year: 2005
    b>Lutein and zeaxanthin are members of the carotenoid family of compounds and are synthesized by plants and microorganisms, in which they have pigmentation and photoprotective roles...
  18. Age-Related Eye Disease Study 2 (AREDS2) Reading Center
    Ronald Danis; Fiscal Year: 2011
    ..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
  19. Age-Related Eye Disease Study 2 (AREDS2) Reading Center
    Ronald Danis; Fiscal Year: 2013
    ..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
  20. Age-Related Eye Disease Study 2 (AREDS2) Reading Center
    Ronald Danis; Fiscal Year: 2012
    ..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
  21. Age-Related Eye Disease Study 2 (AREDS2) Reading Center
    Ronald Danis; Fiscal Year: 2010
    ..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
  22. Age-Related Eye Disease Study 2 (AREDS2) Reading Center
    Ronald Danis; Fiscal Year: 2009
    ..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
  23. Novel vision tests: data analysis from a RP Lutein trial
    Gislin Dagnelie; Fiscal Year: 2004
    ..are currently completing a NCCAM-sponsored placebo-controlled crossover pilot study with a nutrition supplement (lutein), which has previous been shown to have a positive effect on visual acuity and central visual field area in RP ..
  24. INTIMAL THICKENING & ANTITOXIDANTS IN HISPANICS & ANGLOS
    James Dwyer; Fiscal Year: 2003
    ..thickness (IMT) of the common carotid arteries, causal interpretation of which is supported by the findings that lutein inhibits monocyte attraction by LDL oxidized in a model of the artery wall, and that lutein supplementation ..
  25. CNS EFFICACY OF ANTIOXIDANTS FROM PLANTS
    William Cole; Fiscal Year: 1999
    ..beta-carotene from carrots, lutein from parsley, lycopene form tomato paste, and curcumin and turmerin from turmeric...
  26. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2001
    ..for high resolution visual acuity, selectively accumulates two xanthophy11 carotenoids derived from the diet, lutein and zeaxanthin...
  27. CHEMOPREVENTION BY CAROTENOID DERIVATIVES
    John Bertram; Fiscal Year: 2000
    ..more complete understanding of the pharmacology and molecular biological actions of two major dietary carotenoids, lutein and lycopene. Dr...
  28. CLINICAL EPIDEMIOLOGY OF RETINAL DEGENERATIONS
    Alessandro Iannaccone; Fiscal Year: 2005
    ..pigment epithelium- photoreceptor complex, or (2) by reducing the bioavailability of the macular carotenoids, lutein and zeaxanthin to the retina, either via depletion of the systemic pool, or via depletion of the intraretinal pool...
  29. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 1999
    ..The new technology uses Raman spectroscopy to detect the macular carotenoids lutein and zeaxanthin in the human retina...
  30. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  31. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  32. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  33. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  34. Chronic Ingestion of Lutein and Zeaxanthin in Primates
    Frederick Khachik; Fiscal Year: 2003
    ..study has concluded that high consumption of fruits and vegetables, rich specifically in two dietary carotenoids, lutein and zeaxanthin, reduces the risk of a degenerative eye disease called Age-related Macular Degeneration (AMD)...
  35. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  36. Hormones During Weight Loss in Breast Cancer Survivors
    Cheryl Rock; Fiscal Year: 2004
    ....
  37. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  38. Vitamin D and Mammographic Density
    Rulla Tamimi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. HEALTHY WEIGHT MANAGEMENT FOR BREAST CANCER SURVIVORS
    Cheryl Rock; Fiscal Year: 2003
    ..abstract_text> ..
  40. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  41. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 2002
    ..The new technology uses Raman spectroscopy to detect the macular carotenoids lutein and zeaxanthin in the human retina...
  42. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  43. BENIGN BREAST DISEASE AND RISK OF BREAST CANCER
    Rulla Tamimi; Fiscal Year: 2009
    ..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
  44. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  45. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  46. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  47. Integrating and coordinating efforts in COPD guideline development
    Holger Schunemann; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  48. Parenting To Prevent Problem Behaviors
    John Pierce; Fiscal Year: 2005
    ....
  49. 2007 Carotenoids Gordon Research Conference
    John Landrum; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  50. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..
  51. Antiviral/Antitumor Roles of Ganoderma Lucidum Spores
    Rui Liu; Fiscal Year: 2005
    ....
  52. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2002
    ....
  53. Antioxidant nutrients and Oxidative DNA Damage in Afric*
    Jessie Satia; Fiscal Year: 2005
    ..In addition, this work would potentially provide investigators with a validated instrument for assessing antioxidant nutrient exposure in population-based studies in the U.S. ..
  54. STRUCTURE AND FUNCTION OF CAROTENOIDS
    Harry Frank; Fiscal Year: 2008
    ..Several preliminary studies have already been carried out by us in support of the methods we propose to employ. ..
  55. Nutrition Program-Caribbean Hispanic elders & diabetes
    ODILIA BERMUDEZ; Fiscal Year: 2003
    ....
  56. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
  57. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2007
    ..abstract_text> ..
  58. Dietary Factors in Eye Disease
    William Christen; Fiscal Year: 2006
    ..Thus, the proposed analyses represent an extremely cost-effective opportunity to compare directly the predictive ability of several potentially modifiable risk factors for ARM and cataract in women and men. ..
  59. IL-10, Inflammation, and Selective INhibition of Neovascularization
    C Dorey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Postprandial glycemic response to 4-week low and high glycemic load diets
    Marian Neuhouser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Metabolic and Epidemiologic Evaluation of Choline and Betaine Intake
    Eunyoung Cho; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  62. Green Tea Targets COX-2/PGE2 and EFGR Pathways in NSCLC via Stimulating Annexin 1
    Qing Yi Lu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..