Genomes and Genes
Summary: A carotenoid alcohol widespread in nature. It is present in egg yolk, algae, and petals of yellow flowers, among other sources.
Publications267 found, 100 shown here
- The role of the xanthophyll cycle and of lutein in photoprotection of photosystem IIPeter Jahns
Plant Biochemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
Biochim Biophys Acta 1817:182-93. 2012..role of the xanthophylls zeaxanthin (which is formed in the light in the so-called xanthophyll cycle) and lutein with emphasis on the NPQ processes associated with PSII of higher plants...
- Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)Stuart Richer
Department of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064 3095, USA
Optometry 75:216-30. 2004..The objective of the lutein antioxidant supplementation trial (LAST) is to determine whether nutritional supplementation with lutein or lutein ..
- Lutein: more than just a filter for blue lightAize Kijlstra
University Eye Clinic Maastricht, Maastricht, The Netherlands
Prog Retin Eye Res 31:303-15. 2012b>Lutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties...
- Supplementation with all three macular carotenoids: response, stability, and safetyEithne E Connolly
Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
Invest Ophthalmol Vis Sci 52:9207-17. 2011This study was designed to investigate serum and macular response to, and safety of supplementation with, meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z), the carotenoids that constitute macular pigment (MP).
- Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degenerationGünther Weigert
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
Invest Ophthalmol Vis Sci 52:8174-8. 2011There is evidence from several large-scale clinical trials that reduced intake of lutein, a major component of the macular pigment, is a risk factor for the development of AMD...
- Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cellsShasha Gao
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
Mol Vis 17:3180-90. 2011Epidemiological studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract...
- Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetesM Sasaki
Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
Diabetologia 53:971-9. 2010..Here, we focused on oxidative stress in the retina, and analysed its influence on retinal neurodegeneration, using an antioxidant, lutein.
- Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysisLe Ma
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, People s Republic of China
Br J Nutr 107:350-9. 2012b>Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent...
- Biologic mechanisms of the protective role of lutein and zeaxanthin in the eyeNorman I Krinsky
Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
Annu Rev Nutr 23:171-201. 2003..retina is yellow in color due to the presence of the macular pigment, composed of two dietary xanthophylls, lutein and zeaxanthin, and another xanthophyll, meso-zeaxanthin...
- Lutein, zeaxanthin, and the macular pigmentJ T Landrum
Department of Chemistry, Florida International University, Miami 33199, USA
Arch Biochem Biophys 385:28-40. 2001The predominant carotenoids of the macular pigment are lutein, zeaxanthin, and meso-zeaxanthin...
- Identification of StARD3 as a lutein-binding protein in the macula of the primate retinaBinxing Li
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
Biochemistry 50:2541-9. 2011b>Lutein, zeaxanthin, and their metabolites are the xanthophyll carotenoids that form the macular pigment of the human retina...
- The relation between serum lipids and lutein and zeaxanthin in the serum and retina: results from cross-sectional, case-control and case study designsLisa M Renzi
Human Biofactors Laboratory and Vision Sciences Laboratory, The University of Georgia, 601 Psychology Building, Athens, GA 30602 3013, USA
Lipids Health Dis 11:33. 2012The xanthophyll carotenoids lutein (L) and zeaxanthin (Z) are found in and around the macula of the primate retina, where they are termed macular pigment (MP)...
- Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older womenElizabeth J Johnson
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Neurosci 11:75-83. 2008Low dietary intake of docosahexaenoic acid (DHA) and/or foods rich in lutein may be associated with increased risk of cognitive decline in the elderly.
- The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22John Paul SanGiovanni
The EMMES Corporation, 401 N Washington St, Ste 700, Rockville, MD 20850 1707, USA
Arch Ophthalmol 125:1225-32. 2007..To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)...
- Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA StudyCécile Delcourt
Institut National de la Sante et de la Recherche Medicale INSERM, Research Unit U593 for Epidemiology, Public Health and Development, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Invest Ophthalmol Vis Sci 47:2329-35. 2006To assess the associations of plasma lutein and zeaxanthin and other carotenoids with the risk of age-related maculopathy (ARM) and cataract in the population-based Pathologies Oculaires Liées à l'Age (POLA) Study.
- Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitriteTakashi Maoka
Research Institute for Production Development, 15 Shimogamo Morimoto Cho, Sakyo ku, Kyoto 606 0805, Japan
Mar Drugs 10:1391-9. 2012..These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite.
- Nutritional and clinical relevance of lutein in human healthF Granado
Servicio de Endocrinologia y Nutricion, Hospital Universitario Puerta de Hierro, Madrid, Spain
Br J Nutr 90:487-502. 2003b>Lutein is one of the most widely found carotenoids distributed in fruits and vegetables frequently consumed. Its presence in human tissues is entirely of dietary origin...
- Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic strokeSuk Yee Li
Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Neurobiol Dis 45:624-32. 2012..The aim of this study is to investigate the protective roles of lutein in cerebral I/R injury.
- Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA studyMeike Trieschmann
Institute of Ophthalmology, St Franziskus Hospital, and Institute of Epidemiology, University of Munster, Germany
Exp Eye Res 84:718-28. 2007Macular pigment (MP), consisting of lutein (L) and zeaxanthin (Z), is believed to protect the retina from photo-oxidative damage...
- A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degenerationSarah Sabour-Pickett
Department of Optometry, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland
Mol Nutr Food Res 56:270-86. 2012..The dietary carotenoids, lutein (L), zeaxanthin (Z), and meso-zeaxanthin (meso-Z), accumulate at the macula, where they are collectively known as ..
- Distribution of lutein, zeaxanthin, and related geometrical isomers in fruit, vegetables, wheat, and pasta productsJulia M Humphries
Department of Plant Science, Waite Campus, The University of Adelaide, Australia
J Agric Food Chem 51:1322-7. 2003Quantitative data with regard to dietary (3R,3'R,6'R)-lutein, (3R,3'R)-zeaxanthin, and their (E/Z)-geometrical isomers are scarce, and in most cases, only the combined concentrations of these two carotenoids in foods are reported...
- Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest populationJ Curran-Celentano
Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, NH 03824, USA
Am J Clin Nutr 74:796-802. 2001..Information on concentrations of retinal carotenoids (macular pigment, or MP) is of particular interest because MP protects against age-related macular degeneration, the leading cause of irreversible blindness in the United States...
- Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retinaL M Rapp
Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
Invest Ophthalmol Vis Sci 41:1200-9. 2000..The purpose of this study was to determine whether lutein and zeaxanthin, the major carotenoids comprising the macular pigment, are present in rod outer segment (ROS) ..
- Prospective study of lutein/zeaxanthin intake and risk of age-related macular degenerationEunyoung Cho
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 87:1837-43. 2008The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness.
- Biotechnological production of lutein and its applicationsJosé M Fernández-Sevilla
Department of Chemical Engineering, University of Almeria, La Canada de San Urbano, Almeria 04120, Spain
Appl Microbiol Biotechnol 86:27-40. 2010b>Lutein is an antioxidant that has gathered increasing attention due to its potential role in preventing or ameliorating age-related macular degeneration...
- Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin AEliot L Berson
Berman Gund Laboratory for Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Arch Ophthalmol 128:403-11. 2010To determine whether lutein supplementation will slow visual function decline in patients with retinitis pigmentosa receiving vitamin A.
- Carotenoid actions and their relation to health and diseaseNorman I Krinsky
Department of Biochemistry, School of Medicine, Tufts University, 136 Harrison Avenue, Boston, MA 02111 1837, USA
Mol Aspects Med 26:459-516. 2005..The carotenoids that have been most studied in this regard are beta-carotene, lycopene, lutein and zeaxanthin. In part, the beneficial effects of carotenoids are thought to be due to their role as antioxidants...
- The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activationJi Hee Kim
Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
Free Radic Biol Med 45:885-96. 2008..We found that the non-provitamin A carotenoid, lutein, decreased intracellular H(2)O(2) accumulation by scavenging superoxide and H(2)O(2) and the NF-kappaB-regulated ..
- Neuroprotective effect of an antioxidant, lutein, during retinal inflammationMariko Sasaki
Department of Ophthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
Invest Ophthalmol Vis Sci 50:1433-9. 2009b>Lutein has been the focus of recent study as a possible therapeutic approach for retinal diseases, but the molecular mechanism of its neuroprotective effect remains to be elucidated...
- Lutein is needed for efficient chlorophyll triplet quenching in the major LHCII antenna complex of higher plants and effective photoprotection in vivo under strong lightLuca Dall'osto
Dipartimento Scientifico e Tecnologico, Universita di Verona, Strada Le Grazie 15, I 37134 Verona, Italy
BMC Plant Biol 6:32. 2006b>Lutein is the most abundant xanthophyll in the photosynthetic apparatus of higher plants. It binds to site L1 of all Lhc proteins, whose occupancy is indispensable for protein folding and quenching chlorophyll triplets...
- Serum lutein concentrations in healthy term infants fed human milk or infant formula with luteinJodi Bettler
Wyeth, Collegeville, PA, USA
Eur J Nutr 49:45-51. 2010b>Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula...
- Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acidAna J Chucair
Instituto de Investigaciones Bioquímicas de Bahía Blanca INIBIBB and Universidad Nacional del Sur UNS, Bahia Blanca, Buenos Aires, Argentina
Invest Ophthalmol Vis Sci 48:5168-77. 2007..b>Lutein (LUT) and zeaxanthin (ZEA), major components in macular pigment, are among the retinal antioxidants...
- Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degenerationStephen Beatty
Macular Pigment Research Group, Waterford Institute of Technology, Waterford City, Waterford, Republic of Ireland
Ophthalmology 120:600-6. 2013..To report the secondary outcomes in the Carotenoids with Coantioxidants in Age-Related Maculopathy trial...
- Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) studyJessie A Satia
Departments of Nutrition and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Am J Epidemiol 169:815-28. 2009..The authors examined associations of supplemental beta-carotene, retinol, vitamin A, lutein, and lycopene with lung cancer risk among participants, aged 50-76 years, in the VITamins And Lifestyle (VITAL) ..
- Comparison of macular pigment in patients with age-related macular degeneration and healthy control subjects - a study using spectral fundus reflectanceSemira Kaya
Department of Clinical Pharmacology, Medical University of Vienna, Austria
Acta Ophthalmol 90:e399-403. 2012..In this study, we investigated the age dependence of MPOD using spectral fundus reflectance. In addition, we hypothesized that patients with AMD have a reduced MPOD as compared to healthy controls...
- Intake of lutein and zeaxanthin differ with age, sex, and ethnicityElizabeth J Johnson
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Am Diet Assoc 110:1357-62. 2010b>Lutein and zeaxanthin are carotenoids that are selectively taken up into the macula of the eye, where they may protect against development of age-related macular degeneration...
- Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta)Kuzhuvelil Bhaskarannair Harikumar
Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Int J Toxicol 27:1-9. 2008b>Lutein is a carotenoid with antioxidant properties and is commonly present in many fruits, vegetables, and egg yolk...
- Neuroprotective effects of lutein in the retinaYoko Ozawa
Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Curr Pharm Des 18:51-6. 2012..In this review, we focus on lutein, which is a xanthophyll type of carotenoid...
- A central dip in the macular pigment spatial profile is associated with age and smokingMark L Kirby
Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
Invest Ophthalmol Vis Sci 51:6722-8. 2010..To investigate the relationship between specific macular pigment (MP) spatial profiles and risk factors for age-related macular degeneration (AMD)...
- Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory studyEithne E Connolly
Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
Curr Eye Res 35:335-51. 2010At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation.
- Macular pigment optical density in an ageing Irish population: The Irish Longitudinal Study on AgeingJohn M Nolan
Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, and Institute of Vision Research, Whitfield Clinic, Waterford, Ireland jmnolan wit ie
Ophthalmic Res 44:131-9. 2010The 3 carotenoids lutein, zeaxanthin, and meso-zeaxanthin, which account for the 'yellow spot' at the macula and which are referred to as macular pigment (MP), are believed to play a role in visual function and protect against age-related ..
- The relation between the macular carotenoids, lutein and zeaxanthin, and temporal visionLisa M Renzi
Institute for Neuroscience and Center for Perceptual Systems, University of Texas at Austin, Austin, TX, USA
Ophthalmic Physiol Opt 30:351-7. 2010b>Lutein (L) and zeaxanthin (Z) are the dominant carotenoids within the central retina (there, termed macular pigment, MP) and brain (approximately 70% of total carotenoid concentration)...
- The impact of macular pigment augmentation on visual performance in normal subjects: COMPASSJohn M Nolan
Macular Pigment Research Group, Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland
Vision Res 51:459-69. 2011..121 normal subjects were recruited. The active (A) group consumed 12 mg of lutein (L) and 1mg of zeaxanthin (Z) daily...
- A naturally occurring carotenoid, lutein, reduces PDGF and H₂O₂ signaling and compromised migration in cultured vascular smooth muscle cellsHuey Ming Lo
Section of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
J Biomed Sci 19:18. 2012..In this study we examined the effect of the other naturally occurring carotenoid, lutein, on PDGF signaling and migration in VSMCs.
- Inverse association of vitamin C with cataract in older people in IndiaRavilla D Ravindran
Aravind Eye Hospital Pondicherry, Aravind Eye Care, Pondicherry, India
Ophthalmology 118:1958-1965.e2. 2011..To examine the association between vitamin C and cataract in the Indian setting...
- Obesity, lutein metabolism, and age-related macular degeneration: a web of connectionsElizabeth J Johnson
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
Nutr Rev 63:9-15. 2005..Currently there is no effective cure for this disease. Risk factors include decreased lutein and zeaxanthin status and obesity. Obesity is also an increasing public health concern...
- Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trialLe Ma
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China
Am J Ophthalmol 154:625-634.e1. 2012To examine the effects of lutein and zeaxanthin supplementation on retinal function using multifocal electroretinograms (mfERG) in patients with early age-related macular degeneration (AMD).
- Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cellsQingning Bian
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Free Radic Biol Med 53:1298-307. 2012..Epidemiologic studies suggest that insufficient dietary lutein and zeaxanthin intake or lower serum zeaxanthin levels are associated with increased risk for AMD...
- Dietary sources of lutein and zeaxanthin carotenoids and their role in eye healthEl Sayed M Abdel-Aal
Guelph Food Research Centre, Agriculture and Agri Food Canada, Guelph, ON N1G 5C9, Canada
Nutrients 5:1169-85. 2013..Numerous studies have identified lutein and zeaxanthin to be essential components for eye health...
- Synergistic interactions between carotene ring hydroxylases drive lutein formation in plant carotenoid biosynthesisRena F Quinlan
Department of Biological Sciences, Lehman College, City University of New York, Bronx, New York 10468, USA
Plant Physiol 160:204-14. 2012..The formation of lutein, which involves hydroxylation of both β- and ε-rings, was shown to require the coexpression of CYP97A and CYP97C ..
- Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performanceKhalil Mitri
Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universitat Berlin, Institute of Pharmacy, Kelchstr 31, 12169 Berlin, Germany
Int J Pharm 414:267-75. 2011Topical application of lutein as an innovative antioxidant, anti-stress and blue light filter, which is able to protect skin from photo damage, has got a special cosmetic and pharmaceutical interest in the last decade...
- Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish populationJouni Karppi
Department of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
Br J Nutr 108:148-54. 2012..Previous studies have shown that long-term dietary intake of antioxidants (lutein and zeaxanthin) may decrease the risk of age-related cataracts...
- Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degenerationLe Ma
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China
Ophthalmology 119:2290-7. 2012To determine whether supplementation with lutein and zeaxanthin improves macular pigment and visual function in patients with early age-related macular degeneration (AMD).
- Safety assessment of lutein and zeaxanthin (Lutemax 2020): subchronic toxicity and mutagenicity studiesR Ravikrishnan
RCC Laboratories India Pvt Ltd, Genome Valley, Shameerpet, Hyderabad 500 078, AP, India
Food Chem Toxicol 49:2841-8. 2011b>Lutein and zeaxanthin, naturally occurring carotenoids, have shown to reduce the risk of cataracts and age-related macular degeneration...
- Reactive oxygen species and transcript analysis upon excess light treatment in wild-type Arabidopsis thaliana vs a photosensitive mutant lacking zeaxanthin and luteinAlessandro Alboresi
Dipartimento di Biotecnologie, Universita di Verona, Strada Le Grazie 15, Verona, Italy
BMC Plant Biol 11:62. 2011..Despite their destructive activity they are also signalling molecules, priming the acclimatory response to stress stimuli...
- Influence of lutein supplementation on macular pigment, assessed with two objective techniquesT T Berendschot
University Medical Centre Utrecht, Department of Ophthalmology, The Netherlands
Invest Ophthalmol Vis Sci 41:3322-6. 2000..This study was conducted to determine the extent of changes in the macular pigment density as a consequence of oral supplementation with lutein. A second purpose was to compare two objective measurement techniques.
- CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue culturesMyriam Moussa
INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
Mol Nutr Food Res 55:578-84. 2011..However, nothing is known regarding the uptake of carotenoids by adipocytes. Thus, our study explored the mechanism by which lycopene and lutein, two major human plasma carotenoids, are transported.
- Enhancement of lutein production in Chlorella sorokiniana (Chorophyta) by improvement of culture conditions and random mutagenesisBaldo F Cordero
Institute of Plant Biochemistry and Photosynthesis, CIC Cartuja, University of Seville and CSIC, Spain
Mar Drugs 9:1607-24. 2011Chlorella sorokiniana has been selected for lutein production, after a screening of thirteen species of microalgae, since it showed both a high content in this carotenoid and a high growth rate...
- Macular pigment in donor eyes with and without AMD: a case-control studyR A Bone
Department of Physics, Florida International University, Miami, Florida 33199, USA
Invest Ophthalmol Vis Sci 42:235-40. 2001..To determine whether there is an association between the density of macular pigment in the human retina and the risk of age-related macular degeneration (AMD)...
- The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)Emily Y Chew
Division of Epidemiology and Clinical Applications, National Eye Institute National Institutes of Health, Bethesda, Maryland, USA
Ophthalmology 119:2282-9. 2012..The primary purpose of the Age-Related Eye Disease Study 2 (AREDS2) is to evaluate the efficacy and safety of lutein plus zeaxanthin (L+Z) and/or ω-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation in reducing the ..
- Lutein and zeaxanthin and their potential roles in disease preventionJudy D Ribaya-Mercado
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Am Coll Nutr 23:567S-587S. 2004b>Lutein and zeaxanthin are xanthophyll carotenoids found particularly in dark-green leafy vegetables and in egg yolks...
- Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidantsS P Sundelin
Division of Ophthalmology, Department of Neuroscience and Locomotion, Linkoping University, Linkoping, Sweden
Free Radic Biol Med 31:217-25. 2001..support of this idea, we now report significantly reduced formation of lipofuscin when the antioxidant substances lutein, zeaxanthin, lycopene (carotenoids), or alpha-tocopherol were added to rabbit and bovine (calf) retinal pigment ..
- Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degenerationJohanna M Seddon
Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, and Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02111, USA
Mol Vis 16:2412-24. 2010..We evaluated its association and interaction with previously identified genetic variants and modifiable factors...
- Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessmentBenedetto Falsini
Istituto di Oftalmologia, Universita Cattolica del S Cuore, Rome, Italy
Ophthalmology 110:51-60; discussion 61. 2003..To evaluate the influence of short-term antioxidant supplementation on retinal function in age-related maculopathy (ARM) patients by recording focal electroretinograms (FERGs)...
- Photoprotection in the antenna complexes of photosystem II: role of individual xanthophylls in chlorophyll triplet quenchingMilena Mozzo
Department of Biophysical Chemistry, Groningen Bimolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
J Biol Chem 283:6184-92. 2008..The largest part of the triplets is quenched by the lutein bound in site L1, which is located in close proximity to the chlorophylls responsible for the low energy state of ..
- Associations between lutein, zeaxanthin, and age-related macular degeneration: an overviewShannon Carpentier
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Rev Food Sci Nutr 49:313-26. 2009..b>Lutein and zeaxanthin are macular pigments that may play a role in reducing the development and progression of age-..
- Long-term nutrient intake and early age-related nuclear lens opacitiesP F Jacques
Laboratory for Nutrition and Vision, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
Arch Ophthalmol 119:1009-19. 2001..001), vitamin E (P =.02), riboflavin (P =.005), folate (P =.009), beta-carotene (P =.04), and lutein/zeaxanthin (P =.03)...
- Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health InitiativeSuzen M Moeller
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726 2336, USA
Arch Ophthalmol 126:354-64. 2008To evaluate associations between nuclear cataract (determined from slitlamp photographs between May 2001 and January 2004) and lutein and zeaxanthin in the diet and serum in patients between 1994 and 1998 and macula between 2001 and 2004.
- Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expressionRajashree Krishnaswamy
School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore 641046, India
Free Radic Biol Med 49:50-60. 2010..In the present study, the cytoprotective effect of lutein, was tested in HT-29 cells against DON-induced oxidative stress and cytotoxicity...
- β-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-κB and IL-8 expression in gastric epithelial AGS cellsYoungha Kim
Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, Korea
J Nutr Sci Vitaminol (Tokyo) 57:216-23. 2011..Low intake of β-carotene leads to high risk of gastric cancer. Oxygenated carotenoid lutein inhibited NF-κB activation in experimental uveitis...
- Lutein and zeaxanthin in eye and skin healthRichard L Roberts
Kemin Health, LC, 600 E Court Avenue, Suite A, Des Moines, IA 50309 2058, USA
Clin Dermatol 27:195-201. 2009..The body does not synthesize them. Among the carotenoids present in the body, only lutein and its coexistent isomer, zeaxanthin, are found in that portion of the eye where light is focused by the lens, ..
- Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis studyJ H Dwyer
Department of Preventive Medicine, Institute for Prevention Research, Keck School of Medicine, University of Southern California, USA
Circulation 103:2922-7. 2001..The present study assessed the protective effects of the oxygenated carotenoid lutein against early atherosclerosis.
- Macular pigment lutein is antiinflammatory in preventing choroidal neovascularizationKanako Izumi-Nagai
Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Arterioscler Thromb Vasc Biol 27:2555-62. 2007..The aim of the current study was to investigate the effect of lutein supplementation on the development of the murine model of laser-induced CNV together with underlying molecular ..
- Arabidopsis carotenoid mutants demonstrate that lutein is not essential for photosynthesis in higher plantsB Pogson
Department of Plant Sciences, University of Arizona, Tucson 85721, USA
Plant Cell 8:1627-39. 1996b>Lutein, a dihydroxy beta, epsilon-carotenoid, is the predominant carotenoid in photosynthetic plant tissue and plays a critical role in light-harvesting complex assembly and function...
- The evolution and function of carotenoid hydroxylases in ArabidopsisJoonyul Kim
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
Plant Cell Physiol 50:463-79. 2009..Surprisingly, triple mutants containing only CYP97C1 or CYP97A3 activity produced 74 and 6% of the wild-type lutein level, indicating that CYP97C1 can efficiently hydroxylate both the beta- and epsilon-rings of alpha-carotene and ..
- Macular pigment density and aging, assessed in the normal elderly and those with cataracts and age-related macular degenerationThomas A Ciulla
Retina Service, Midwest Eye Institute, Methodist Medical Plaza North, Indianapolis, Indiana 46280, USA
Am J Ophthalmol 138:582-7. 2004Increasing evidence has linked retinal lutein and zeaxanthin (termed macular pigment, MP) to the risk of age-related macular degeneration (AMD)...
- Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cellsNilesh M Kalariya
AMD Center, Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1106, USA
Curr Eye Res 34:737-47. 2009To investigate the genotoxic effects of lutein (LBP) and beta -carotene breakdown products (beta -apo-8-carotenal, BA8C) and the preventive role of GSH in human retinal pigment epithelial cells (ARPE-19).
- [Lutein and antioxidants in the prevention of age-related macular degeneration]M Rehak
Klinik und Poliklinik für Augenheilkunde, Universitat Leipzig, Leipzig, Deutschland
Ophthalmologe 105:37-8, 40-5. 2008..The macular pigment consists mostly of lutein and zeaxanthin...
- Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthinWendy M R Broekmans
TNO Nutrition and Food Research, Zeist, Netherlands
Am J Clin Nutr 76:595-603. 2002Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration...
- Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) studyWolfgang Schalch
DSM Nutritional Products Ltd, NRD CH, Building 203 855, Wurmisweg 576, CH 4303, Kaiseraugst, Switzerland
Arch Biochem Biophys 458:128-35. 2007The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea...
- Lutein supplementation alters inflammatory cytokine production and antioxidant status in F-line turkeysR Shanmugasundaram
Department of Animal Sciences, Ohio Agricultural Research and Development Center, Wooster, OH, USA
Poult Sci 90:971-6. 2011Effect of dietary lutein supplementation on turkey production parameters, cytokine production, and oxidative status during an acute phase response following lipopolysaccharide (LPS) injection was studied...
- Macular pigment: quantitative analysis on autofluorescence imagesM Trieschmann
Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring 74, 48145 Münster, Germany
Graefes Arch Clin Exp Ophthalmol 241:1006-12. 2003..In the present study a quantification analysis of MP in AF images was developed to verify these MP types and to compare MP distribution patterns between healthy individuals and those with age-related macular degeneration (AMD)...
- Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthinStephen Beatty
Macular Pigment Laboratory, Waterford Institute of Technology, Cork Road, Waterford, Ireland
Arch Biochem Biophys 430:70-6. 2004..b>Lutein (L) and zeaxanthin (Z) are two hydroxy-carotenoids with antioxidant activity which accumulate at the macula, where ..
- A lutein-enriched diet prevents cholesterol accumulation and decreases oxidized LDL and inflammatory cytokines in the aorta of guinea pigsJung Eun Kim
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
J Nutr 141:1458-63. 2011b>Lutein has been shown to be protective against age-related macular degeneration; however, the antiinflammatory and antioxidant effects of this carotenoid in aortas are less known. Guinea pigs were fed a hypercholesterolemic diet (0...
- The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporterWilliam E Connor
Division of Endocrinology, Metabolism, and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
Invest Ophthalmol Vis Sci 48:4226-31. 2007b>Lutein and zeaxanthin are largely transported in plasma by high-density lipoprotein (HDL)...
- Serum carotenoids and oxidative DNA damage in human lymphocytesA R Collins
Rowett Research Institute, Bucksburn, Aberdeen, UK
Carcinogenesis 19:2159-62. 1998..pyrimidines and altered purines in the DNA of lymphocytes from volunteers supplemented with alpha/beta-carotene, lutein, lycopene or placebo...
- Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humansRichard A Bone
Department of Physics, Florida International University, Miami 33199, USA
J Nutr 133:992-8. 2003..Increased risk of AMD may result from low levels of lutein and zeaxanthin (macular pigment) in the diet, serum or retina, and excessive exposure to blue light...
- Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory responseRamesh K Selvaraj
Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
Comp Biochem Physiol A Mol Integr Physiol 157:198-203. 2010This study investigated the effects of dietary lutein and polyunsaturated fatty acids (PUFA) on the total lutein and lipid levels, the peroxisome proliferators activated receptors (PPAR) alpha and gamma, retinoic acid X receptor (RXR) ..
- Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis ratsXue Hai Jin
Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Invest Ophthalmol Vis Sci 47:2562-8. 2006b>Lutein deposits in the macula and lens of human eyes with high concentration and is well known as an eye-protective nutrient for its beneficial effects on eye disease such as age-related macular degeneration and cataract...
- Alternative splicing, activation of cryptic exons and amino acid substitutions in carotenoid biosynthetic genes are associated with lutein accumulation in wheat endospermCrispin A Howitt
CSIRO Food Futures National Research Flagship, Canberra, Australia
Funct Integr Genomics 9:363-76. 2009..epsilon-LCY) and phytoene synthase (Psy-A1), were identified as candidate genes for two of the QTL affecting lutein content in wheat endosperm...
- [Effect of lutein on relieving oxidative stress in mice induced by D-galatose]Jiayi Mai
Department of Nutrition and Food Hygiene, School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China
Wei Sheng Yan Jiu 39:430-2. 2010To study the effect of lutein on relieving oxidative stress in the liver of mice induced by D-galactose(D-gal).
- Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patientsNicolas Cardinault
Unité des Maladies Métaboliques et Micronutriments, INRA Clermont Ferrand Theix, 63122 St Genes Champanelle, France
Clin Chim Acta 357:34-42. 2005..The aim of this study was to determine carotenoid levels in serum and in different lipoprotein fractions in patients diagnosed for ARMD and in matched control group...
- Absorption and metabolism of dietary carotenoidsAkihiko Nagao
National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
Biofactors 37:83-7. 2011..carotenoids found in human tissues, however, are limited to several including such as β-carotene, lycopene, and lutein. We have little knowledge of whether carotenoids are selectively absorbed in intestine and metabolized ..
- The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the fieldJohn Paul SanGiovanni
National Eye Institute, Clinical Trials Branch, Bethesda, MD 20892 1863, USA
Am J Clin Nutr 96:1223S-33S. 2012..In this article we review the history and state of science on the putative role of the MXs (lutein, zeaxanthin, and meso-zeaxanthin) in AMD and report findings on AMD-associated genes encoding enzymes, ..
- Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stressDong Wei
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China
Sci China C Life Sci 51:1088-93. 2008..has attracted interest as a promising organism for commercial production of a high-value carotenoid, lutein, by heterotrophic fermentation...
- Lutein prevents cataract development and progression in diabetic ratsEmma Arnal
Departamento de Fisiologia, Farmacología and Toxicología, Universidad CEU Cardenal Herrera, Avda Seminario s n, 46113 Moncada, Valencia, Spain
Graefes Arch Clin Exp Ophthalmol 247:115-20. 2009..It is often associated with complications, such as cataracts. Cataract, characterized by cloudiness or opacity of the eye lens, is the leading cause of blindness worldwide...
- Keto-carotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissuesLina Yonekura
National Food Research Institute, NARO, Tsukuba, Ibaraki 305 8642, Japan
J Nutr 140:1824-31. 2010..the metabolism, tissue distribution, and depletion of fucoxanthin in ICR mice by comparison with those of lutein. The experiments comprised 14-d dietary supplementation with lutein esters or fucoxanthin, followed by 41- or 28-d,..
- Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta)J A Del Campo
Instituto de Bioquimica Vegetal y Fotosintesis, Centro de Investigaciones Cientificas Isla de la Cartuja, Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Avda Americo Vespucio s n, 41092 Sevilla, Spain
Appl Microbiol Biotechnol 64:848-54. 2004..zofingiensis strain CCAP 211/14 accumulates a significant amount of valuable carotenoids, namely astaxanthin and lutein, of increasing demand for use as feed additives in fish and poultry farming, as colorants in food, and in health ..
- High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch cultureXian Ming Shi
Key Laboratory of Microbiology of Agricultural Ministry, Huazhong Agricultural University, Wuhan 430070, P R China
Biotechnol Prog 18:723-7. 2002..Such a modification resulted in an enhanced lutein production without significantly lowering biomass production. The cellular lutein content was 0...
- Carotenoids from in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (Gallus gallus domesticus)Elizabeth A Koutsos
Department of Animal Science, California Polytechnic State University, San Luis Obispo, CA 93407, USA
J Nutr 136:1027-31. 2006b>Lutein, a dihydroxycarotenoid, has antioxidant and immunomodulatory potential...
- Risk assessment for the carotenoids lutein and lycopeneAndrew Shao
Council for Responsible Nutrition, 1828 L St, NW, Suite 900, Washington, DC 20036 5114, USA
Regul Toxicol Pharmacol 45:289-98. 2006b>Lutein and lycopene, two prevalent carotenoids in the human diet have become increasingly popular ingredients in dietary supplements...
- Risk factors for orofacial cleftsSuzan L Carmichael; Fiscal Year: 2011..that protect against oxidative stress ([unreadable]- and [unreadable]-carotene, cryptoxanthin, cysteine, folate, lutein, lycopene, oleic acid, pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group ..
- BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDSPAUL STEVEN BERNSTEIN; Fiscal Year: 2013DESCRIPTION (provided by applicant): Lutein, zeaxanthin, and their metabolites are dietary xanthophyll carotenoids that are specifically concentrated in the macula lutea of the human eye where they are thought to provide protection ..
- Quantitation of In Vivo Human Lutein MetabolismANDREW JOSEPH CLIFFORD; Fiscal Year: 2010DESCRIPTION (provided by applicant): Lutein is an oxygenated carotenoid (xanthophyll) found in dark green leafy vegetables...
- Glutathione S-Transferase Pi in Age-Related Macular DegenerationWen Hsiang Lee; Fiscal Year: 2013..Concentrated in the human macula are dietary carotenoid antioxidants lutein and zeaxanthin, and their levels have been found to be lower in AMD compared to elderly control eyes...
- Diet and Lifestyle Factors Reducing Risk for Age-Related Eye DiseaseJulie A Mares; Fiscal Year: 2013..We recently reported evidence to support protective roles of vitamin D, the macular carotenoids, lutein and zeaxanthin, healthy diet patterns and physical activity against the development of early/intermediate stages ..
- Age-Related Eye Disease Study 2 (AREDS2) Coordinating CenterTraci Clemons; Fiscal Year: 2009Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD...
- Age-Related Eye Disease Study 2 (AREDS2) Coordinating CenterTraci Clemons; Fiscal Year: 2010Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD...
- Age-Related Eye Disease Study 2 (AREDS2) Coordinating CenterTraci Clemons; Fiscal Year: 2011Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD...
- CONTROL OF CORPUS LUTEUM FUNCTIONJohn Gadsby; Fiscal Year: 1990..PL will be used to test the presence of PL bioactivity during the isolation and purification process; granulosa lutein cells taken from corpora lutea taken on day 1 of pseudopregnancy will be dissociated with collagenase and ..
- FAT SOLUBLE MICRONUTRIENTS IN HUMAN PLASMA AND TISSUESNORMAN KRINSKY; Fiscal Year: 1993..gamma-tocopherol and carotenoids such as beta- carotene, alpha-carotene, lycopene, alpha-and beta-cryptoxanthins, lutein, zeaxanthin and the more polar epoxycarotenoids, neoxanthin and violaxanthin...
- GENE-DIET INTERACTIONS AND HEART DISEASEHANNAI CAMPOS; Fiscal Year: 2003..We will study whether high intakes of alpha-linolenic acid, vitamin E, carotene, particularly alpha- carotene, lutein, and lycopene reduce the risk of CHD, and whether the GDAS marker variants alleles lessen this protective effect...
- REPRODUCTIVE TOXICOLOGY AND EPIDEMIOLOGYBill Lasley; Fiscal Year: 2003..TCDD as a model compound to investigate the ovary and the placenta as major targets of toxicity to human granulosa lutein cells and human trophoblast cells...
- Effects of Antioxidants on Human Macular PigmentsKyung Jin Yeum; Fiscal Year: 2006..Low dietary intake or low blood levels of lutein and zeaxanthin, which are the only pigments found in the macular region of the human retina, has been associated ..
- Plasma Markers of Dietry Intervention to Delay Cognitiv*JAE KANG; Fiscal Year: 2005..we propose to prospectively examine plasma markers of a wide array of antioxidants (alpha-carotene, beta-carotene, lutein/zeaxanthin, lycopene, beta-cryptoxanthin, alpha-tocopherol and gamma-tocopherol) and homocysteine, folate and ..
- EFFECTS OF LUTEIN IN RETINITIS PIGMENTOSAGislin Dagnelie; Fiscal Year: 2001..a recent patient-initiated pilot study demonstrated that RP patients may respond to a nutrition supplement (lutein) with a modest, but statistically significant gain in visual acuity and central visual field area; demonstrating ..
- MACULAR BIOCHEMISTRYALICE ADLER; Fiscal Year: 1999..Aims are to answer the following questions: l) What is the mechanism by which the macular-pigment carotenoids, lutein and zeaxanthin, shown to be protective against AMD, are selectively accumulated in the foveal region of the ..
- XANTHOPHYLL-MEDIATED RETINAL DRUG DELIVERYDennis Marcus; Fiscal Year: 2005b>Lutein and zeaxanthin are members of the carotenoid family of compounds and are synthesized by plants and microorganisms, in which they have pigmentation and photoprotective roles...
- Age-Related Eye Disease Study 2 (AREDS2) Reading CenterRonald Danis; Fiscal Year: 2011..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
- Age-Related Eye Disease Study 2 (AREDS2) Reading CenterRonald Danis; Fiscal Year: 2013..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
- Age-Related Eye Disease Study 2 (AREDS2) Reading CenterRonald Danis; Fiscal Year: 2012..4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD...
- Age-Related Eye Disease Study 2 (AREDS2) Reading CenterRonald Danis; Fiscal Year: 2010
- Age-Related Eye Disease Study 2 (AREDS2) Reading CenterRonald Danis; Fiscal Year: 2009
- Novel vision tests: data analysis from a RP Lutein trialGislin Dagnelie; Fiscal Year: 2004..are currently completing a NCCAM-sponsored placebo-controlled crossover pilot study with a nutrition supplement (lutein), which has previous been shown to have a positive effect on visual acuity and central visual field area in RP ..
- INTIMAL THICKENING & ANTITOXIDANTS IN HISPANICS & ANGLOSJames Dwyer; Fiscal Year: 2003..thickness (IMT) of the common carotid arteries, causal interpretation of which is supported by the findings that lutein inhibits monocyte attraction by LDL oxidized in a model of the artery wall, and that lutein supplementation ..
- CNS EFFICACY OF ANTIOXIDANTS FROM PLANTSWilliam Cole; Fiscal Year: 1999..beta-carotene from carrots, lutein from parsley, lycopene form tomato paste, and curcumin and turmerin from turmeric...
- BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDSPaul Bernstein; Fiscal Year: 2001..for high resolution visual acuity, selectively accumulates two xanthophy11 carotenoids derived from the diet, lutein and zeaxanthin...
- CHEMOPREVENTION BY CAROTENOID DERIVATIVESJohn Bertram; Fiscal Year: 2000..more complete understanding of the pharmacology and molecular biological actions of two major dietary carotenoids, lutein and lycopene. Dr...
- CLINICAL EPIDEMIOLOGY OF RETINAL DEGENERATIONSAlessandro Iannaccone; Fiscal Year: 2005..pigment epithelium- photoreceptor complex, or (2) by reducing the bioavailability of the macular carotenoids, lutein and zeaxanthin to the retina, either via depletion of the systemic pool, or via depletion of the intraretinal pool...
- RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTSWerner Gellermann; Fiscal Year: 1999..The new technology uses Raman spectroscopy to detect the macular carotenoids lutein and zeaxanthin in the human retina...
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANSMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- Chronic Ingestion of Lutein and Zeaxanthin in PrimatesFrederick Khachik; Fiscal Year: 2003..study has concluded that high consumption of fruits and vegetables, rich specifically in two dietary carotenoids, lutein and zeaxanthin, reduces the risk of a degenerative eye disease called Age-related Macular Degeneration (AMD)...
- Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older WomenRichard Semba; Fiscal Year: 2008..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
- Hormones During Weight Loss in Breast Cancer SurvivorsCheryl Rock; Fiscal Year: 2004....
- Hepcidin and the pathogenesis of anemia in older adults.Richard D Semba; Fiscal Year: 2010..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
- Vitamin D and Mammographic DensityRulla Tamimi; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- HEALTHY WEIGHT MANAGEMENT FOR BREAST CANCER SURVIVORSCheryl Rock; Fiscal Year: 2003..abstract_text> ..
- VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDRENRichard Semba; Fiscal Year: 2002....
- RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTSWerner Gellermann; Fiscal Year: 2002..The new technology uses Raman spectroscopy to detect the macular carotenoids lutein and zeaxanthin in the human retina...
- MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIVRichard Semba; Fiscal Year: 2001..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
- BENIGN BREAST DISEASE AND RISK OF BREAST CANCERRulla Tamimi; Fiscal Year: 2009..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
- ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDSRichard Semba; Fiscal Year: 2005....
- Iron Deficiency and Anemia in HIV and HCV-Infected WomenRichard Semba; Fiscal Year: 2005..S. and elsewhere. ..
- THE UCLA CLINICAL NUTRITION RESEARCH UNITDavid Heber; Fiscal Year: 2006..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
- Integrating and coordinating efforts in COPD guideline developmentHolger Schunemann; Fiscal Year: 2007..End of Abstract) [unreadable] [unreadable] [unreadable]..
- Parenting To Prevent Problem BehaviorsJohn Pierce; Fiscal Year: 2005....
- 2007 Carotenoids Gordon Research ConferenceJohn Landrum; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- UCLA TRAINING PROGRAM IN NUTRITION AND OBESITYDavid Heber; Fiscal Year: 2007..abstract_text> ..
- Antiviral/Antitumor Roles of Ganoderma Lucidum SporesRui Liu; Fiscal Year: 2005....
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 2002....
- Antioxidant nutrients and Oxidative DNA Damage in Afric*Jessie Satia; Fiscal Year: 2005..In addition, this work would potentially provide investigators with a validated instrument for assessing antioxidant nutrient exposure in population-based studies in the U.S. ..
- STRUCTURE AND FUNCTION OF CAROTENOIDSHarry Frank; Fiscal Year: 2008..Several preliminary studies have already been carried out by us in support of the methods we propose to employ. ..
- Nutrition Program-Caribbean Hispanic elders & diabetesODILIA BERMUDEZ; Fiscal Year: 2003....
- Molecular Epidemiology of non-Hodgkin Lymphoma SurvivalJames R Cerhan; Fiscal Year: 2010..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
- Eye Disease in a Trial of Selenium and Vitamin EWilliam Christen; Fiscal Year: 2007..abstract_text> ..
- Dietary Factors in Eye DiseaseWilliam Christen; Fiscal Year: 2006..Thus, the proposed analyses represent an extremely cost-effective opportunity to compare directly the predictive ability of several potentially modifiable risk factors for ARM and cataract in women and men. ..
- IL-10, Inflammation, and Selective INhibition of NeovascularizationC Dorey; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Postprandial glycemic response to 4-week low and high glycemic load dietsMarian Neuhouser; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Metabolic and Epidemiologic Evaluation of Choline and Betaine IntakeEunyoung Cho; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Green Tea Targets COX-2/PGE2 and EFGR Pathways in NSCLC via Stimulating Annexin 1Qing Yi Lu; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..