vitamin a

Summary

Summary: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

Top Publications

  1. ncbi The biosynthesis and nutritional uses of carotenoids
    Paul D Fraser
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK
    Prog Lipid Res 43:228-65. 2004
  2. ncbi Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia
    M A Dijkhuizen
    Division of Human Nutrition and Epidemiology, Wageningen University, Netherlands
    Am J Clin Nutr 73:786-91. 2001
  3. pmc Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Med 15:401-9. 2009
  4. ncbi From carrot to clinic: an overview of the retinoic acid signaling pathway
    Maria Theodosiou
    Institut de Génomique Fonctionnelle de Lyon, Université de Lyon Université Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Cell Mol Life Sci 67:1423-45. 2010
  5. pmc Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein
    L Quadro
    Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    EMBO J 18:4633-44. 1999
  6. ncbi A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
    Riki Kawaguchi
    Department of Physiology, David Geffen School of Medicine at UCLA, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Science 315:820-5. 2007
  7. ncbi The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes
    L Alpsoy
    Fatih University, Faculty of Art and Science, Department of Biology, Istanbul, Turkey
    Toxicol Ind Health 25:121-7. 2009
  8. ncbi Effects of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysis
    D I Thurnham
    Northern Ireland Centre for Food and Health, Faculty of Life and Health Sciences, University of Ulster, Coleraine, UK
    Lancet 362:2052-8. 2003
  9. pmc Vitamin A and retinoic acid in T cell-related immunity
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 96:1166S-72S. 2012
  10. pmc Giardiasis and poor vitamin A status among aboriginal school children in rural Malaysia
    Hesham M Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:523-7. 2010

Detail Information

Publications361 found, 100 shown here

  1. ncbi The biosynthesis and nutritional uses of carotenoids
    Paul D Fraser
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK
    Prog Lipid Res 43:228-65. 2004
    ....
  2. ncbi Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia
    M A Dijkhuizen
    Division of Human Nutrition and Epidemiology, Wageningen University, Netherlands
    Am J Clin Nutr 73:786-91. 2001
    BACKGROUND: Deficiencies of vitamin A, iron, and zinc are prevalent worldwide, affecting vulnerable groups such as lactating women and infants. However, the existence of concurrent deficiencies has received little attention...
  3. pmc Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Med 15:401-9. 2009
    ..acid metabolizing enzyme retinaldehyde dehydrogenase type 2 and interleukin-10 (IL-10) and to metabolize vitamin A and stimulate Foxp3(+) T regulatory cells (T(reg) cells)...
  4. ncbi From carrot to clinic: an overview of the retinoic acid signaling pathway
    Maria Theodosiou
    Institut de Génomique Fonctionnelle de Lyon, Université de Lyon Université Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Cell Mol Life Sci 67:1423-45. 2010
    b>Vitamin A is essential for the formation and maintenance of many body tissues. It is also important for embryonic growth and development and can act as a teratogen at critical periods of development...
  5. pmc Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein
    L Quadro
    Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    EMBO J 18:4633-44. 1999
    Retinol-binding protein (RBP) is the sole specific transport protein for retinol (vitamin A) in the circulation, and its single known function is to deliver retinol to tissues...
  6. ncbi A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
    Riki Kawaguchi
    Department of Physiology, David Geffen School of Medicine at UCLA, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Science 315:820-5. 2007
    b>Vitamin A has diverse biological functions...
  7. ncbi The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes
    L Alpsoy
    Fatih University, Faculty of Art and Science, Department of Biology, Istanbul, Turkey
    Toxicol Ind Health 25:121-7. 2009
    The aim of this study was to investigate the possible protective role of vitamin A, C, and E on aflatoxin B(1)-induced in human lymphocytes using biochemical approaches...
  8. ncbi Effects of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysis
    D I Thurnham
    Northern Ireland Centre for Food and Health, Faculty of Life and Health Sciences, University of Ulster, Coleraine, UK
    Lancet 362:2052-8. 2003
    b>Vitamin A deficiency adversely affects child morbidity and survival...
  9. pmc Vitamin A and retinoic acid in T cell-related immunity
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 96:1166S-72S. 2012
    Interest in vitamin A as a regulator of immune function goes back to the early 1900s...
  10. pmc Giardiasis and poor vitamin A status among aboriginal school children in rural Malaysia
    Hesham M Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:523-7. 2010
    A cross-sectional study was carried out on 241 primary schoolchildren in Pahang, Malaysia to update their vitamin A status and to investigate the association of poor vitamin A status with their health and socioeconomic factors...
  11. ncbi The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22
    John Paul SanGiovanni
    The EMMES Corporation, 401 N Washington St, Ste 700, Rockville, MD 20850 1707, USA
    Arch Ophthalmol 125:1225-32. 2007
    To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS).
  12. pmc Vitamin A and retinoid signaling: genomic and nongenomic effects
    Ziad Al Tanoury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Sante et de la Recherche Medicale INSERM, U964, CNRS, UMR7104, Universite de Strasbourg, 67404 Illkirch Cedex, France
    J Lipid Res 54:1761-75. 2013
    b>Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is essential from embryogenesis to adulthood...
  13. pmc Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation
    Ming Fu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 137:631-40. 2010
    ..RA) is crucial for GDNF-induced ENS precursor migration, cell polarization and lamellipodia formation, and that vitamin A depletion causes distal bowel aganglionosis in serum retinol-binding-protein-deficient (Rbp4(-/-)) mice...
  14. pmc Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance
    Barbara Cassani
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Aspects Med 33:63-76. 2012
    The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses...
  15. ncbi Impact of vitamin A on selected gastrointestinal pathogen infections and associated diarrheal episodes among children in Mexico City, Mexico
    Kurt Z Long
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 194:1217-25. 2006
    The overall effect of vitamin A supplementation on diarrheal disease in community trials may result from its effect on specific diarrheal pathogens.
  16. ncbi Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland, and The Ministry of Health, Rabat, Morocco
    Am J Clin Nutr 84:580-6. 2006
    b>Vitamin A deficiency impairs iron metabolism; vitamin A supplementation of vitamin A-deficient populations may reduce anemia. The mechanism of these effects is unclear...
  17. pmc Provitamin A metabolism and functions in mammalian biology
    Johannes von Lintig
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Clin Nutr 96:1234S-44S. 2012
    b>Vitamin A deficiency is a major public health problem in developing countries. Some studies also implicate a suboptimal vitamin A intake in certain parts of the population of the industrialized world...
  18. pmc STRA6-catalyzed vitamin A influx, efflux, and exchange
    Riki Kawaguchi
    Department of Physiology, Jules Stein Eye Institute and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Membr Biol 245:731-45. 2012
    b>Vitamin A has diverse biological functions and is essential for human survival. STRA6 is the high-affinity membrane receptor for plasma retinol binding protein (RBP), the principle and specific carrier of vitamin A (retinol) in the blood...
  19. ncbi Vitamin A and iron status are improved by vitamin A and iron supplementation in pregnant Indonesian women
    Sherry A Tanumihardjo
    Department of Nutritional Sciences, University of Wisconsin Madison, 53706 1571, USA
    J Nutr 132:1909-12. 2002
    In Indonesia, deficiencies of vitamin A and iron are of public health concern during pregnancy. We sought to determine the effects of vitamin A and iron supplementation on the vitamin A and iron status of pregnant Indonesian women...
  20. ncbi Hepatic stellate cell (vitamin A-storing cell) and its relative--past, present and future
    Haruki Senoo
    Departments of Cell Biology and Morphology, Akita University Graduate School of Medicine, 111 Hondo, Akita City, Akita 0108543, Japan
    Cell Biol Int 34:1247-72. 2010
    HSCs (hepatic stellate cells) (also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells or Ito cells) exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule ..
  21. pmc Efficacy of early neonatal vitamin A supplementation in reducing mortality during infancy in Ghana, India and Tanzania: study protocol for a randomized controlled trial
    Rajiv Bahl
    Department of Maternal Newborn Child and Adolescent Health, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland
    Trials 13:22. 2012
    b>Vitamin A supplementation of 6-59 month old children is currently recommended by the World Health Organization based on evidence that it reduces mortality...
  22. pmc The key role of vitamin A in spermatogenesis
    Cathryn A Hogarth
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 7520, USA
    J Clin Invest 120:956-62. 2010
    ..hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous ..
  23. ncbi The acute and chronic toxic effects of vitamin A
    Kristina L Penniston
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Am J Clin Nutr 83:191-201. 2006
    The acute and chronic effects of vitamin A toxicity are well documented in the literature...
  24. ncbi Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children
    Leslie G Payne
    School of Dietetics and Human Nutrition and 4Institute of Parasitology, McGill University Macdonald Campus, Quebec, Canada
    J Nutr 137:1455-9. 2007
    Despite the common coexistence of vitamin A deficiency and Ascaris infection in preschool children in developing countries, and despite the widespread use of vitamin A supplements, remarkably little is understood about the impact of ..
  25. pmc Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses
    Daniel C Berry
    Department of Pharmacology and Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 108:4340-5. 2011
    It currently is believed that vitamin A, retinol, functions through active metabolites: the visual chromophore 11-cis-retinal, and retinoic acids, which regulate gene transcription...
  26. ncbi Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro
    Kenjiro Ono
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Exp Neurol 189:380-92. 2004
    ..we used fluorescence spectroscopy with thioflavin T (ThT) and electron microscopy to examine the effects of vitamin A (retinol, retinal, and retinoic acid), beta-carotene, and vitamins B2, B6, C, and E on the formation, extension, ..
  27. pmc Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
    Evan Mayo-Wilson
    Centre for Evidence Based Intervention, Department of Social Policy and Intervention, University of Oxford, UK
    BMJ 343:d5094. 2011
    To determine if vitamin A supplementation is associated with reductions in mortality and morbidity in children aged 6 months to 5 years.
  28. pmc Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A
    Eliot L Berson
    Berman Gund Laboratory for Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 128:403-11. 2010
    To determine whether lutein supplementation will slow visual function decline in patients with retinitis pigmentosa receiving vitamin A.
  29. ncbi The effect of high-dose vitamin A supplementation administered with BCG vaccine at birth may be modified by subsequent DTP vaccination
    Christine Stabell Benn
    Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark
    Vaccine 27:2891-8. 2009
    Unexpectedly, we found no overall beneficial effect on mortality in a randomised trial of vitamin A supplementation (VAS) or placebo administered with BCG vaccine at birth in Guinea-Bissau...
  30. pmc Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group
    K P West
    Johns Hopkins School of Hygiene and Public Health, Division of Human Nutrition, Room 2041, 615 N Wolfe Street, Baltimore, MD 21205, USA
    BMJ 318:570-5. 1999
    To assess the impact on mortality related to pregnancy of supplementing women of reproductive age each week with a recommended dietary allowance of vitamin A, either preformed or as beta carotene.
  31. ncbi The effect of vitamin A supplementation on the intestinal immune response in Mexican children is modified by pathogen infections and diarrhea
    Kurt Z Long
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 136:1365-70. 2006
    b>Vitamin A supplementation has consistently reduced infant mortality and the severity of pathogen-induced diarrhea. The mechanism by which vitamin A modulates the mucosal immune response to produce these effects remains poorly defined...
  32. pmc Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes
    Eduardo Villamor
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Clin Microbiol Rev 18:446-64. 2005
    b>Vitamin A supplementation to preschool children is known to decrease the risks of mortality and morbidity from some forms of diarrhea, measles, human immunodeficiency virus (HIV) infection, and malaria...
  33. ncbi Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A
    Rosalie Molenaar
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 186:1934-42. 2011
    The vitamin A metabolite retinoic acid (RA) plays a crucial role in mucosal immune responses...
  34. pmc Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes
    Qing Zhou
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
    Biol Reprod 79:35-42. 2008
    b>Vitamin A is required for male fertility and normal spermatogenesis...
  35. ncbi Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake
    Francisco Felipe
    Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Crta Valldemossa km 7 5, 07122 Palma de Mallorca, Spain
    Biochim Biophys Acta 1740:258-65. 2005
    Retinoic acid (RA) administration and chronic vitamin A supplementation were reported to inhibit adipose tissue leptin expression in rodents, but the impact of this effect on food intake and its relationship with changes of body ..
  36. pmc High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation
    Seung G Kang
    Department of Comparative Pathobiology, Laboratory of Immunology and Hematopoiesis, Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    Gastroenterology 137:1391-402.e1-6. 2009
    ..Because retinoic acid is produced as a metabolite of vitamin A in the intestine and FoxP3(+) T cells regulate intestinal inflammation, we investigated the impact of vitamin A ..
  37. ncbi Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid
    L Deltour
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 274:16796-801. 1999
    ..Redundant roles for Adh1 and Adh4 in retinoic acid production may explain the apparent normal development of mutant mice...
  38. pmc Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India
    Lakshmi Rahmathullah
    Aravind Centre for Women, Children and Community Health, Madurai, Tamil Nadu, India
    BMJ 327:254. 2003
    To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months.
  39. pmc Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Kurt H Albertine
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
    Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010
    ..b>Vitamin A supplementation has improved respiratory outcome of premature infants, but there is little information about the ..
  40. ncbi beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements
    Christopher Davis
    Department of Nutritional Sciences, University of Wisconsin Madison, 1415 Linden Drive, Madison, WI 53706, USA
    Br J Nutr 100:786-93. 2008
    ..enhanced provitamin A carotenoids (biofortified), accomplished through conventional plant breeding, maintains vitamin A (VA) status in Mongolian gerbils (Meriones unguiculatus)...
  41. ncbi Vitamin A equivalence of the ß-carotene in ß-carotene-biofortified maize porridge consumed by women
    Shanshan Li
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011 1120, USA
    Am J Clin Nutr 92:1105-12. 2010
    Carotene-biofortified maize is being developed through plant breeding as a sustainable agronomic approach to alleviate vitamin A deficiency.
  42. pmc Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial
    Christine Stabell Benn
    Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark
    BMJ 340:c1101. 2010
    To investigate the effect of vitamin A supplementation and BCG vaccination at birth in low birthweight neonates.
  43. pmc Vitamin A and retinoic acid in the regulation of B-cell development and antibody production
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA
    Vitam Horm 86:103-26. 2011
    Signaling by vitamin A through its active metabolite retinoic acid (RA) is critical for the normal development and functions of the hematopoietic and immune systems...
  44. pmc Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein
    Jaume Amengual
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 287:24216-27. 2012
    b>Vitamin A (all-trans-retinol) must be adequately distributed within the mammalian body to produce visual chromophore in the eyes and all-trans-retinoic acid in other tissues...
  45. ncbi Vitamin A metabolism in rod and cone visual cycles
    John C Saari
    Department of Ophthalmology and Biochemistry, University of Washington, Seattle, WA 91895, USA
    Annu Rev Nutr 32:125-45. 2012
    ..Recent progress in the characterization of rod and cone visual cycle components and reactions will result in the development of approaches to the amelioration of blinding eye diseases associated with visual cycle defects...
  46. pmc Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis
    Daniel C Berry
    Department of Pharmacology and Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4695, USA
    Biochim Biophys Acta 1821:168-76. 2012
    b>Vitamin A, retinol, circulates in blood bound to serum retinol binding protein (RBP) and is transported into cells by a membrane protein termed stimulated by retinoic acid 6 (STRA6)...
  47. ncbi Selling Sprinkles micronutrient powder reduces anemia, iron deficiency, and vitamin A deficiency in young children in Western Kenya: a cluster-randomized controlled trial
    Parminder S Suchdev
    Nutrition Branch, CDC, Atlanta, GA 30341, USA
    Am J Clin Nutr 95:1223-30. 2012
    ....
  48. ncbi Single nucleotide polymorphisms upstream from the β-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers
    Georg Lietz
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    J Nutr 142:161S-5S. 2012
    ..In summary, a range of SNPs can influence the effectiveness of using plant-based provitamin A carotenoids to increase vitamin A status in at-risk population groups and this effect may vary depending on ethnic origin.
  49. pmc Vitamin A: biomarkers of nutrition for development
    Sherry A Tanumihardjo
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Am J Clin Nutr 94:658S-65S. 2011
    b>Vitamin A is essential for multiple functions in mammals. Without vitamin A, mammals cannot grow, reproduce, or fight off disease. Because of its numerous functions in humans, biomarkers of vitamin A status are quite diverse...
  50. pmc C20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease
    Li Ma
    Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 286:7966-74. 2011
    ..In this work we investigated the effects of long-term administration of deuterium-enriched vitamin A, C20-D(3)-vitamin A, on RPE lipofuscin deposition and eye function in a mouse model of Stargardt's disease...
  51. pmc The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor
    X Edward Zhou
    Laboratory of Structural Sciences and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 286:2877-85. 2011
    ..These findings demonstrate that TR4 is a ligand-regulated nuclear receptor and suggest that retinoids might have a much wider regulatory role via activation of orphan receptors such as TR4...
  52. ncbi How vitamin A metabolizing dendritic cells are generated in the gut mucosa
    William W Agace
    Immunology Section, Lund University, Lund, Sweden
    Trends Immunol 33:42-8. 2012
    ..Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC ..
  53. pmc Multiple cytochrome P-450 genes are concomitantly regulated by vitamin A under steady-state conditions and by retinoic acid during hepatic first-pass metabolism
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Genomics 43:57-67. 2011
    b>Vitamin A (retinol) is an essential precursor for the production of retinoic acid (RA), which in turn is a major regulator of gene expression, affecting cell differentiation throughout the body...
  54. ncbi Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency
    P V Bhat
    CHUM Research Centre Hôtel Dieu Campus, Department of Medicine, University of Montreal, Que, Canada
    FEBS Lett 426:260-2. 1998
    ..have examined RALDH expression in the stomach and small intestine before and during postnatal development and in vitamin A deficiency by assaying for mRNA levels and protein as well as for enzyme activity...
  55. pmc β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children
    Guangwen Tang
    Carotenoids and Health Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 96:658-64. 2012
    Golden Rice (GR) has been genetically engineered to be rich in β-carotene for use as a source of vitamin A.
  56. ncbi A global clinical view on vitamin A and carotenoids
    Alfred Sommer
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21209, USA
    Am J Clin Nutr 96:1204S-6S. 2012
    The clinical importance of vitamin A as an essential nutrient has become increasingly clear. Adequate vitamin A is required for normal organogenesis, immune competence, tissue differentiation, and the visual cycle...
  57. pmc Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX
    Glenn P Lobo
    Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    J Biol Chem 288:9017-27. 2013
    Low dietary intake of β-carotene is associated with chronic disease and vitamin A deficiency...
  58. pmc Vitamin A metabolism and adipose tissue biology
    Simone K Frey
    Department of Medicine and the Institute of Human Nutrition, Columbia University, New York, NY 10032, USA
    Nutrients 3:27-39. 2011
    In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology...
  59. ncbi Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part II--vitamin D, vitamin A, iron, zinc, iodine, essential fatty acids
    Joe Leigh Simpson
    Florida International University, College of Medicine, Miami, FL 33199, USA
    J Matern Fetal Neonatal Med 24:1-24. 2011
    ..In foods of animal origin, preformed Vitamin A is present; in plants (fruits and vegetables) vitamin A precursors (β-carotenoids) are present...
  60. pmc Vitamin A supplementation in Tanzania: the impact of a change in programmatic delivery strategy on coverage
    Honorati Masanja
    Ifakara Health Research and Development Center, Ifakara, Morogoro, Tanzania
    BMC Health Serv Res 6:142. 2006
    ..impact of a change in programmatic delivery strategy from routine delivery through the Expanded Programme on Immunization (EPI+) approach to twice-yearly mass distribution campaigns on coverage of vitamin A supplementation in Tanzania
  61. ncbi Genetic defects in vitamin A metabolism of the retinal pigment epithelium
    Debra A Thompson
    Departments of Ophthalmology and Visual Sciences, and Biological Chemistry, University of Michigan Medical School, Ann Arbor, Mich, USA
    Dev Ophthalmol 37:141-54. 2003
    The metabolism of vitamin A and cycling of retinoids between the retinal pigment epithelium (RPE) and the neural retina is a complex process involving a specialized enzymes and proteins...
  62. pmc Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism
    Julie Norseen
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:2010-9. 2012
    ..This process reveals a novel JNK- and TLR4-dependent and retinol- and STRA6-independent mechanism of action for RBP4...
  63. pmc Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase
    Alexander R Moise
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:50230-42. 2004
    ..Thus, saturation of all-trans-retinol to all-trans-13,14-dihydroretinol by RetSat produces a new metabolite of yet unknown biological function...
  64. ncbi Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein
    Saskia de Pee
    Helen Keller International Helen Keller Worldwide Asia Pacific Regional Office, Jakarta, Indonesia
    J Nutr 132:2895S-2901S. 2002
    Two biochemical indicators are currently recommended for determining whether vitamin A deficiency (VAD) is a public health problem: serum retinol and serum retinol-binding protein (RBP)...
  65. ncbi Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination Survey
    C B Stephensen
    US Department of Agriculture, Western Human Nutrition Research Center, Davis, CA, USA
    Am J Clin Nutr 72:1170-8. 2000
    Serum retinol decreases transiently during the acute phase response and can thus result in misclassification of vitamin A status.
  66. ncbi Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids
    Sharon E Cox
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 10:1286-97. 2005
    b>Vitamin A supplementation is believed to enhance immune responses to infection but few studies have assessed its effects on anti-malarial immunity, especially during pregnancy when women are at increased risk from both vitamin A ..
  67. ncbi Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry
    Ralph Ruhl
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Hungary
    Rapid Commun Mass Spectrom 20:2497-504. 2006
    ..This method allows ultra-sensitive detection, excellent selectivity and a very simple sample preparation to determine retinoic acids, 4-oxo-retinoic acids and retinol in serum and cell extracts for the study of endogenous retinoids...
  68. pmc Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity
    D L Misner
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, Howard Hughes Medical Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:11714-9. 2001
    Despite its long history, the central effects of progressive depletion of vitamin A in adult mice has not been previously described...
  69. pmc Effectiveness of measles vaccination and vitamin A treatment
    Christopher R Sudfeld
    Johns Hopkins Bloomberg School of Public Health, Department of International Health, Baltimore, MD 21205, USA
    Int J Epidemiol 39:i48-55. 2010
    ..to reach the Global Immunization Vision and Strategy 2010 measles reduction goal includes increasing coverage of measles vaccine, vitamin A treatment and supplementation in addition to offering two doses of vaccine to all children.
  70. ncbi The beneficial effects of weekly low-dose vitamin A supplementation on acute lower respiratory infections and diarrhea in Ecuadorian children
    F Sempertegui
    Corporación Ecuatoriana de Biotecnología Ecuadorian Biotechnology Corporation, Escuela de Medicina, Universidad Central del Ecuador, Quito, Ecuador
    Pediatrics 104:e1. 1999
    Previous studies of large-dose vitamin A supplementation on respiratory morbidity have produced conflicting results in a variety of populations. The influence of malnutrition has not been examined in the majority of these trials...
  71. pmc Vitamin A in reproduction and development
    Margaret Clagett-Dame
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Nutrients 3:385-428. 2011
    The requirement for vitamin A in reproduction was first recognized in the early 1900's, and its importance in the eyes of developing embryos was realized shortly after...
  72. ncbi Role of retinoid signalling in the adult brain
    Michelle A Lane
    Department of Human Ecology, Division of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, USA
    Prog Neurobiol 75:275-93. 2005
    b>Vitamin A (all-trans-retinol) is the parent compound of a family of natural and synthetic compounds, the retinoids...
  73. pmc Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells
    E Jaensson-Gyllenbäck
    Department of Experimental Medical Sciences, Immunology Section, Lund University, Lund, Sweden
    Mucosal Immunol 4:438-47. 2011
    ..Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine ..
  74. ncbi Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin
    J Varani
    Departments of Pathology and Dermatology, The University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    J Invest Dermatol 114:480-6. 2000
    ..In addition, we determined whether topical vitamin A (retinol) could stimulate new collagen deposition in sun-protected aged skin, as it does in photoaged skin...
  75. ncbi Effectiveness of an early supplementation scheme of high-dose vitamin A versus standard WHO protocol in Gambian mothers and infants: a randomised controlled trial
    Momodou K Darboe
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 369:2088-96. 2007
    Most developing countries have adopted a standard WHO dosing schedule for vitamin A supplementation...
  76. ncbi Diverse actions of retinoid receptors in cancer prevention and treatment
    Nigel P Mongan
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA
    Differentiation 75:853-70. 2007
    Retinoids (retinol [vitamin A] and its biologically active metabolites) are essential signaling molecules that control various developmental pathways and influence the proliferation and differentiation of a variety of cell types...
  77. ncbi Vitamin A, infection, and immune function
    C B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, California 95616, USA
    Annu Rev Nutr 21:167-92. 2001
    In populations where vitamin A availability from food is low, infectious diseases can precipitate vitamin A deficiency by decreasing intake, decreasing absorption, and increasing excretion...
  78. ncbi Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin
    Giuseppe Zanotti
    Department of Organic Chemistry, University of Padova, 35131 Padua, Italy
    Vitam Horm 69:271-95. 2004
    ..Overall, the available evidence indicates the existence of a high degree of complementarity between RBP and TTR, the contact areas of which are highly sensitive to conformational changes and amino acid replacements...
  79. ncbi History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
    A Geerts
    Department of Medical Cell Biology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Semin Liver Dis 21:311-35. 2001
    ..Wake also established that these cells were important sites of vitamin A storage...
  80. ncbi Influence of neonatal vitamin A or vitamin D treatment on the concentration of biogenic amines and their metabolites in the adult rat brain
    K Tekes
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Horm Metab Res 41:277-80. 2009
    Newborn male rats were treated with a single dose of 3 mg vitamin A (retinol) or 0...
  81. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
    ..Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine...
  82. ncbi Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 79:47-53. 2004
    ..Growing evidence suggests that lycopene has significant in vitro antioxidant potential. Lycopene has rarely been tested in prospective studies for its role in cardiovascular disease (CVD) prevention...
  83. ncbi Effect of vitamin A supplementation in women of reproductive age on maternal survival in Ghana (ObaapaVitA): a cluster-randomised, placebo-controlled trial
    Betty R Kirkwood
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 375:1640-9. 2010
    A previous trial in Nepal showed that supplementation with vitamin A or its precursor (betacarotene) in women of reproductive age reduced pregnancy-related mortality by 44% (95% CI 16-63)...
  84. pmc Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
    Sheila M O'Byrne
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:35647-57. 2005
    ..The fatty acyl composition of these (chylomicron) retinyl esters suggests that they are synthesized via an acyl-CoA-dependent process suggesting the existence of a physiologically significant acyl-CoA:retinol acyltransferase...
  85. ncbi The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
    Chi Liang Eric Yen
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA
    J Lipid Res 46:1502-11. 2005
    ..Our findings indicate that DGAT1 can utilize a variety of acyl acceptors as substrates in vitro and suggest that these activities may be relevant to the in vivo functions of DGAT1...
  86. ncbi Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal
    Parul Christian
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W2041, Baltimore, MD 21205, USA
    JAMA 304:2716-23. 2010
    ..Few studies have examined whether iron and zinc supplementation during gestation, a critical period of central nervous system development, affects children's later functioning...
  87. ncbi A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    T Perlmann
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Genes Dev 9:769-82. 1995
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways.
  88. ncbi RPE lipofuscin and its role in retinal pathobiology
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Exp Eye Res 80:595-606. 2005
    ..Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues...
  89. pmc Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye
    Yoshikazu Imanishi
    Department of Ophthalmology, University of Washington, 1959 NE Pacific St, Box 356485, Seattle, WA 98195 6485, USA
    J Cell Biol 164:373-83. 2004
    ..These results indicate that RESTs located close to the RPE plasma membrane are essential components in 11-cis-retinal production...
  90. pmc HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues
    MAUREEN A KANE
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Anal Biochem 378:71-9. 2008
    ..The assays described here provide for sensitive and rigorous quantification of endogenous RE, ROL, and RAL to elucidate retinoid homeostasis in disease states such as Alzheimer's disease, type 2 diabetes, obesity, and cancer...
  91. ncbi Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis
    M W Seeliger
    University Eye Hospital, Department II, Tubingen, Germany
    Invest Ophthalmol Vis Sci 40:3-11. 1999
    ..To describe the phenotype caused by a retinol deficiency in a family with compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP)...
  92. ncbi Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Aspects Med 24:421-30. 2003
    Retinoids (vitamin A and its derivatives) play an essential role in many biological functions. However mammals are incapable of de novo synthesis of vitamin A and must acquire it from the diet...
  93. ncbi Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age
    Ane B Fisker
    Bandim Health Project, INDEPTH Network, Bissau, Guinea Bissau
    Am J Clin Nutr 86:1032-9. 2007
    The effect of vitamin A supplementation (VAS) at birth on subsequent vitamin A status has not been studied.
  94. pmc Beta-carotene is an important vitamin A source for humans
    Tilman Grune
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
    J Nutr 140:2268S-2285S. 2010
    ..Ascertaining the impact of β-carotene on the total dietary intake of vitamin A is complicated, because the efficiency of conversion of β-carotene to retinol is not a single ratio and ..
  95. ncbi Roles of vitamin A status and retinoids in glucose and fatty acid metabolism
    Shi Zhao
    The Diabetes Center, Wuhan Central Hospital, Wuhan, Hubei 430014, China
    Biochem Cell Biol 90:142-52. 2012
    The rising prevalence of metabolic diseases, such as obesity and diabetes, has become a public health concern. Vitamin A (VA, retinol) is an essential micronutrient for a variety of physiological processes, such as tissue differentiation,..
  96. ncbi Vitamin A intake and status in populations facing economic stress
    Keith P West
    Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Nutr 140:201S-7S. 2010
    Dietary quality and diversity reflect adequacy of vitamin A. Both can deteriorate in response to economic crises...
  97. ncbi Feasibility of using retinol-binding protein from capillary blood specimens to estimate serum retinol concentrations and the prevalence of vitamin A deficiency in low-resource settings
    Jonathan L Gorstein
    University of Washington, School of Public Health, Department of Health Services, Seattle, WA 98195 7660, USA
    Public Health Nutr 11:513-20. 2008
    b>Vitamin A deficiency (VAD) is a significant public health problem in many countries. While cost-effective interventions are available to control VAD, reliable information is needed to the track progress of control programmes...
  98. pmc Vitamin A deficiency and attributable mortality among under-5-year-olds
    J H Humphrey
    Department of Ophthalmology, Johns Hopkins University, Baltimore, MD 21205 2179
    Bull World Health Organ 70:225-32. 1992
    Reported are estimates of the prevalence in developing countries of physiologically significant vitamin A deficiency and the number of attributable deaths...
  99. ncbi A randomized trial of multivitamin supplements and HIV disease progression and mortality
    Wafaie W Fawzi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:23-32. 2004
    ..Results from observational studies suggest that micronutrient status is a determinant of the progression of human immunodeficiency virus (HIV) disease...
  100. pmc Increased adiposity in the retinol saturase-knockout mouse
    Alexander R Moise
    Department of Pharmacology, University of Kansas, Lawrence, KS, USA
    FASEB J 24:1261-70. 2010
    ..in contrast to wild-type mice, are deficient in the production of all-trans-13,14-dihydroretinol from dietary vitamin A. Despite accumulating more fat, RetSat-null mice maintained on either low-fat or high-fat diets gain weight and ..
  101. ncbi Effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar, insulin, apoprotein B and apoprotein A-I in patients with type I diabetes
    Farzad Shidfar
    School of Health, Iran University of Medical Sciences, Tehran 1449614525, Iran
    Int J Food Sci Nutr 61:182-91. 2010
    There is accumulating evidence that shows the metabolism of zinc and vitamin A are altered in diabetes mellitus type I (DMTI), thus the present study was conducted to evaluate the effects of combination of zinc and vitamin A ..

Research Grants82

  1. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..However, before safe and effective clinical trials aimed at repleting vitamin A and carotenoid stores in high-risk patients can be designed, we need exploratory studies to: a) determine the ..
  2. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Introduction: Epidemiological evidence highlights the influence of vitamin A (retinol) and its active metabolite, all-trans retinoic acid (ATRA) on the incidence of breast and prostate cancers in ..
  3. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..Retinoids (vitamin A and its metabolites) are potent transcriptional regulators that are needed for mediating normal cell ..
  4. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..Similar results have been reported with many other nutrients and nutrient derivatives (ie, vitamin A, vitamin E, etc)...
  5. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..Their high costs remain obstacles to universal adoption. In developing countries, widespread vitamin A deficiencies (VAD) compromise children's health, gut immune responses and vaccine effectiveness...
  6. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John M Sullivan; Fiscal Year: 2013
    ..This proposed study is a proof-of-concept test of a novel gene therapy strategy for dry AMD. Success in a mouse model is a first essential step toward human clinical trials, which could be conducted in the VA system. ..
  7. Towards Induction of Cell Transplant Tolerance
    Lina Lu; Fiscal Year: 2013
    ..We have found that hepatic stellate cell (HSC), the principle retinoid (vitamin A) storing cells in the body and known to participate in repair and fibrosis during liver injury, also play a ..
  8. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..unreadable]- and [unreadable]-carotene, cryptoxanthin, cysteine, folate, lutein, lycopene, oleic acid, pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group metabolism - betaine, choline, ..
  9. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2013
    ..Again, with funding from this grant, we have developed a knockout mouse model (LRAT null mice) in which vitamin A (retinol) deficiency can be generated quickly and easily...
  10. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    ..Death rates from COPD are higher among cigarette smokers and numerous findings suggest a possible association of vitamin A nutritional status with COPD and lifetime cigarette smoking...
  11. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..A subset of children will be tested for blood concentrations of vitamin A, E, zinc and C-reactive protein, as well as measures of intestinal permeability...
  12. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
    ABSTRACT The essential role of vitamin A for the vertebrate eye has long been known because deficiency in or excess of this vitamin can impair eye development and function...
  13. Cleavage Products of Dietary Carotenoids: Occurrence &Nutritional Function
    EARL HOWARD HARRISON; Fiscal Year: 2013
    ..was their metabolic conversion via cleavage at the central double bond to the essential micronutrient, vitamin A (retinol)...
  14. Unfolded Protein Response as a Therapeutic Target for ADRP Animal Models
    Marina Gorbatyuk; Fiscal Year: 2013
    ..Although supplementation with vitamin A may be beneficial in some cases, currently, there is no effective pharmacological therapy for ADRP...
  15. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
    ..rodent tissues will be optimized diets through dietary adjuvants, upregulation of intestinal uptake by moderate vitamin A deficiency, and cross breeding of various transgenic mice targeted to the carotenoid metabolic pathways...
  16. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..Contributions of HIV infection both in mothers and infants, vitamin A and zinc deficiency, weight for age Z-scores as well as mid upper arm circumference will also be assessed...
  17. Genetics of Alopecia Areata in the C3H/HeJ Mouse
    JOHN PAUL SUNDBERG; Fiscal Year: 2013
    ..Environmental (vitamin A levels in the diet) effects on disease severity were first identified in the mouse and recently confirmed in ..
  18. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
    ..5 years at diagnosis to evaluate the independent association of common genetic polymorphisms involved in folate, vitamin A, and related metabolic and transport pathways with the risk of NB...
  19. VitaminA and Sickle Cell Disease:Improving Suboptimal Status with Supplementation
    KELLY ANN DOUGHERTY; Fiscal Year: 2013
    ..The proposed research project will focus on suboptimal vitamin A (vit A) status which is prevalent in children with type SS sickle cell disease (SCD-SS) and associated with ..
  20. Biomarker discovery for mitochondrial toxicants using metabolic footprinting
    David M Hockenbery; Fiscal Year: 2013
    ..modifiers: 1) genetically engineered mice with low and high glutathione levels, and 2) fatty liver due to vitamin A deficiency...
  21. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..For instance, the vitamin A active compound retinoic acid, working in conjunction with TGF-[unreadable], is known to have a positive impact ..
  22. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
    ..Our laboratory has studied the mechanisms by which retinoids (vitamin A (retinol) and its derivatives and metabolites), control gene expression in both normal stem cells and in tumors...
  23. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    The nutritional status of the mother is a key factor for the development and growth of the fetus. Vitamin A is an essential nutrient for the developing embryo, which depends on maternal circulating vitamin A (or retinoids) to fulfill ..
  24. Regulation of vitamin A metabolism during Schistosoma mansoni infection
    PNG LOKE; Fiscal Year: 2013
    ..Micronutrients such as vitamin A may play a critical role in regulating the inflammatory immune response during helminth infection...
  25. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2013
    ..The research described in this proposal may eventually allow for the development of a safe and effective oral approach to male contraception, which will serve to greatly decrease the risk of unintended pregnancy and population growth. ..
  26. Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways
    Li na Wei; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinoic acid (RA), the biologically active form of vitamin A, acts, primarily, by binding to nuclear RA receptor (RAR) and retinoid receptor X (RXR) to regulate gene expression...
  27. Investigating Regulation of Integral Membrane Protein Cofactor Biosynthesis using
    Ronald F Peck; Fiscal Year: 2011
    ..is found in the eyes of many animals, including humans, and consists of an opsin membrane protein and a Vitamin A retinal cofactor. In these systems, an exquisite balance of protein and cofactor is maintained...
  28. Retinoids and Hyperoxic Lung Injury
    Masheika L James; Fiscal Year: 2012
    ..is a predisposing factor for BPD, which is associated with low plasma and tissue concentrations of retinol (vitamin A;VA)...
  29. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2013
    ..Along with cataract, macular degeneration, infectious disease, and vitamin A deficiency, myopia is one of the most important causes of visual impairment worldwide...
  30. Epigenetic Changes in Retinoid Signaling in Oral Cavity Carcinogenesis
    KATARZYNA MARIA MARCINKIEWICZ; Fiscal Year: 2013
    ..Normal human oral cavity epithelial cells respond to the signaling molecule retinoic acid (RA), a vitamin A derivative, by reducing their proliferation rate...
  31. Tissue specific production of RBP4 and mechanism of insulin resistance
    Timothy E Graham; Fiscal Year: 2013
    ..RBP4 is the sole specific transport protein for Vitamin A (retinol) in blood...
  32. Molecular Regulation of LRAT and CYP26 in Lung and Liver
    A Catharine Ross; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Diet-derived vitamin A (retinol) is first stored in tissues as retinyl esters (RE), which, through hydrolysis and controlled oxidative metabolism generate bioactive retinoids, including retinoic acid ..
  33. Malaria in Pregnancy: Nutrition and Immunologic Effects
    Wafaie W Fawzi; Fiscal Year: 2013
    ..b>Vitamin A and zinc deficiencies are specific factors which can modulate the clinical course of malaria and exacerbate ..
  34. Vitamin A dependent events in urinary tract formation.
    Cathy Mendelsohn; Fiscal Year: 2009
    ..PROJECT SUMMARY (See instructions): Vitamin A is required for formation of most organs and tissues...
  35. Epigenetics participate in neonatal CLD
    Kurt H Albertine; Fiscal Year: 2013
    ..Exciting new data suggest that two interventions (histone deacetylase [HDAC] inhibitors;vitamin A+retinoic acid, VARA) during MV improve alveolar formation and change epigenetic characteristics...
  36. Nutritional Epidemiology of Lower Urinary Tract Symptoms
    Nancy Nairi Maserejian; Fiscal Year: 2010
    ..associations between intakes of carbohydrate, protein, types of fat, sodium, cholesterol, vitamin C, vitamin A, carotenoids, calcium and zinc, and LUTS, voiding symptoms, post micturition symptoms, and storage symptoms, ..
  37. Retinoic Acid Modulation for Scleroderma
    BERT J W M OEHLEN; Fiscal Year: 2012
    ..All-trans-retinoic acid (ATRA) is the most active metabolite of vitamin A and has been shown to have antifibrotic properties in several preclinical models of systemic sclerosis...
  38. Epithelia Associated Dendritic Cells: Phenotype and Function
    Rodney D Newberry; Fiscal Year: 2010
    ..in response to pathogenic or non- pathogenic signals respectively, sample lumenal stimuli, including dietary vitamin A, and subsequently migrate to mesenteric lymph nodes (MLN) to initiate vitamin A dependent mucosal adaptive ..
  39. Interaction of Vitamin D &Vitamin A with Lung Cancer Risk in Non-Smoking Females
    Marian L Neuhouser; Fiscal Year: 2013
    ..In addition, we hypothesize that vitamin A may modify the association of serum 25(OH)D with lung cancer risk...
  40. Short-Chain Dehydrogenases in Retinol/Sterol Metabolism
    Natalia Y Kedishvili; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vitamin A derivative all-trans-retinoic acid regulates the expression of over 530 different genes...
  41. Retinoid receptor antagonists as novel male contraceptives
    Debra J Wolgemuth; Fiscal Year: 2013
    ..All trans retinoic acid (ATRA) is an active metabolite of vitamin A and exerts its function at least in part by binding to nuclear receptors of the steroid hormone superfamily, the ..
  42. Targeting multiple skin cancer pathways using citrus auraptene and ATRA
    J Michael Mathis; Fiscal Year: 2012
    ..We have shown that a combination of the well-characterized chemopreventive vitamin A metabolite, all-trans retinoic acid (ATRA), with the bioactive dietary agent auraptene (AUR), can ..
  43. Animal Model to Study Retinoic Acid Function in Postnatal and Adult Tissues
    GREGG L DUESTER; Fiscal Year: 2012
    ..b>Vitamin A (retinol) is an essential nutrient that serves as a precursor for RA synthesis through a two step metabolic ..
  44. Postprandial Vitamin A
    William S Blaner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vitamin A is required by the body for maintaining many important physiological functions including normal growth and development, a healthy immune response, normal reproduction, and normal vision...
  45. Aldo-keto reductase family 1 member B10 AKR1B10 in pancreatic carcinogenesis
    Guang Yu Yang; Fiscal Year: 2013
    ..Aim 3: To determine the synergistic effect of retinol (vitamin A) and diclofenac on inhibiting pancreatic carcinogenesis in PanKras mice and to determine if the synergistic ..
  46. Molecular Mechanism of Vitamin A Uptake for Vision
    Hui Sun; Fiscal Year: 2011
    The first step in vision is the absorption of light by the chromophore of visual pigments. Vitamin A (retinol) is the precursor for visual pigment chromophore and also has important roles in retina development...
  47. Growth in Childhood and Cardiometabolic Risk in Nepal
    Parul Christian; Fiscal Year: 2012
    ..measurements taken among 5,574 subjects during infancy and childhood during their participation in two vitamin A supplementation trials in the 1990's who were recently revisited and examined as adolescents and young ..
  48. Molecular Events in Urinary Tract Formation
    CATHY LEE MENDELSOHN; Fiscal Year: 2012
    ..In the current proposal, we will determine in Aim 1, whether vitamin A controls Ret expression directly, inducing its transcription in CND cells, or indirectly, by inducing urogenital ..
  49. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2013
    ..However, it is virtually unknown regarding the biological action of the released vitamin A. It was speculated that the released vitamin A is converted to RA, the biological form, and then bound to its ..
  50. Long term Impact and Intervention for Diarrhea in Brazil
    Richard L Guerrant; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project will examine the long-term impact of zinc and Vitamin A, with or without glutamine or arginine, using completed clinical trials of interventions for diarrhea in children in northeast ..
  51. Postprandial Vitamin A
    WILLIAM BLANER; Fiscal Year: 2009
    PROJECT SUMMARY Vitamin A is required by the body for maintaining many important physiological functions including the maintenance of normal growth and development, a healthy immune response, normal reproduction, and normal vision...
  52. Ethanol effects on retinoic acid function in embryo hippocampus
    Joseph L Napoli; Fiscal Year: 2013
    ..dams on the concentration and function of atRA (all-trans-retinoic acid) in the embryo hippocampus during normal vitamin A nutriture, using new techniques for quantifying atRA and new insights into retinoid function in the hippocampus...
  53. Cytokine modulated model growth inhibitory mechanisms
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..The studies proposed in this application will define how tumor- specific dysfunctions in GRIM-19 affect the functioning of this new growth regulatory pathway. ..
  54. Endometriosis and Retinoids
    Serdar E Bulun; Fiscal Year: 2013
    ..in endometriotic tissue compared with matched endometrium: STRA6, a membrane receptor responsible for retinol (vitamin A) uptake, and CRABP2, which channels cytosolic RA to its nuclear receptor RAR1 to enhance apoptosis and reduce ..
  55. Serum 25(OH)D, Vitamin D Intake, and Breast Cancer Recurrence in the WHEL Study
    Elizabeth T Jacobs; Fiscal Year: 2010
    ..between dietary and supplemental intake of vitamin D and breast cancer recurrence;3) Explore whether calcium, vitamin A, carotenoids, or body size, modify the association between 25(OH)D and breast cancer recurrence using serum ..
  56. Role of Retinoid Mediated Signaling in Diabetes and Cardiac Remodeling
    KENNETH MELVIN BAKER; Fiscal Year: 2010
    ..It has been shown that DM also affects the metabolic availability of vitamin A. Activation of RXR-mediated signaling improves insulin resistance in type 2 DM, indicating that RA signaling is ..
  57. Vitamin A Supplementation and Retinol Metabolism in the Neonatal Period
    A Catharine Ross; Fiscal Year: 2013
    At birth, the concentrations of vitamin A (VA, retinol) in liver and plasma are much lower than in older children and well-fed adults...
  58. Novel L-threo-sphinganines for ceramides-based cancer therapy
    Barry J Maurer; Fiscal Year: 2012
    ..If so, they will be candidates for future translational studies in combination with our novel intravenous fenretinide formulation, which is currently moving into Phase 2 trials. ..
  59. Vitamin A-Mediated Protection in Measles
    Diane E Griffin; Fiscal Year: 2013
    ..The only available "treatment" for measles is vitamin A. Vitamin A given during the acute phase of disease decreases mortality, but the mechanism for this protective ..
  60. Alcohol-induced liver fibrosis:an in vitro model
    Raj M Lakshman; Fiscal Year: 2012
    Hepatic stellate cells ( HSC) are liver perisinusoidal cells that store vitamin A and triglycerides and play a role in maintaining vascular tone...
  61. Characterization and Treatment of the Scarred Vocal Fold
    Nathan Welham; Fiscal Year: 2013
    ..poorly understood but potentially transformative areas of investigation in VF scar biology is the role of the vitamin A- storing VF stellate cell...
  62. The Role of Muller Cells in Visual Pigment Regeneration
    Gabriel H Travis; Fiscal Year: 2013
    ..to take place through a novel biochemical mechanism: absorption of a 550-nm photon by a radical-cation of vitamin A inside the DES1 protein...
  63. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    A randomized clinical trial was conducted to examine the effect of antenatal vitamin A supplementation on vertical transmission of HIV, birth weight, and other health outcomes in Malawi...
  64. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2005
    ..of human beta-carotene 15,15'-dioxygenase (BCDO), an enzyme that catalyzes the first step in the synthesis of vitamin A from dietary provitamin A carotenoids...
  65. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..women is related to lower rates of breastfeeding transmission among women in advanced stage of disease, whereas vitamin A supplementation is associated with an overall increased risk...
  66. Maternal transfer of protection from allergic gastrointestinal disease
    Lynn Puddington; Fiscal Year: 2009
    ..g. vitamin A [retinol] and its metabolites) to nursing offspring...
  67. BREATH ETHANE, BIOMARKER OF VITAMIN A AND E DEFICIENCY
    Kathleen Schwarz; Fiscal Year: 1993
    ..In 90 mothers, at 28 weeks gestation, breath ethane will be correlated with serum vitamin A (SVA), retinol-binding protein (RBP), serum vitamin E (SVE), and SVE:total lipids...
  68. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the Investigator's Abstract) Vitamin A (retinol) must be metabolized to an active retinoid ligand in order to fulfill all of its roles in vertebrate development...
  69. Retinyl Ester Binding Proteins and the Visual Cycle
    Robert Rando; Fiscal Year: 2007
    ..retinal pigment epithelium (RPE) by those biochemical reactions involved in the processing of all-trans-retinol (vitamin A) into 11-cis-retinol(al)...
  70. ISOMERIC RETINOIDS, CAROTENOIDS, THEIR PROTEIN COMPLEXES
    Robert Liu; Fiscal Year: 2001
    The importance of vitamin A in health research is self-evident. During the past grant periods, we completed the synthesis of all 16 possible geometric isomers...
  71. Reversible vitamin A-dependent arrest of spermatogonia
    JAMES TSURUTA; Fiscal Year: 2007
    ..is the rational design of contraceptive strategies based on the reversible arrest of spermatogonia (Spg) in the vitamin A-deficient (VAD) testis. Our intent is to uncover specific mechanisms that reversibly arrest Spg in this model...
  72. HYDROLYSIS OF VITAMIN A ESTERS IN LIVER
    EARL HARRISON; Fiscal Year: 2007
    ..by applicant): Hydrolysis of retinyl esters (RE) in the liver plays a key role in the body's metabolism of vitamin A. Dietary vitamin A enters the liver as RE in chylomicron remnants, which undergo hydrolysis and reesterification ..
  73. VITAMIN A TRANSPORT DURING LACTATION
    A Ross; Fiscal Year: 1992
    The goal of the proposed research is to obtain basic information on the mechanisms of delivery of vitamin A to the mammary gland during lactation, and on cellular retinoid binding proteins that may facilitate intracellular transport and ..
  74. RETINOL-MEDICATED REGULATION OF SPERMATOGENESIS
    Kwan Kim; Fiscal Year: 1993
    b>Vitamin A has been shown to be an essential extracellular regulator for the normal development of germ cells in the mammalian testis...
  75. RETINOID-BINDING PROTEINS
    PER PETERSON; Fiscal Year: 1992
    ..Such proteins are engaged in the transport of the vitamin from its storage site in the liver to vitamin A-requiring peripheral tissues...
  76. Regulation of spermatogonial stem cells by vitamin A
    Derek McLean; Fiscal Year: 2007
    ..The objective of this proposal, the first step toward attaining our long-range goal, is to determine the role vitamin A plays in regulating SSC differentiation and self-renewal...
  77. Effects of Vitamin A Deficiency on Virus-Infected Airwa*
    Stephen McGowan; Fiscal Year: 2003
    ..illnesses are a major cause of morbidity and mortality in children worldwide, but particularly in regions where vitamin A deficiency (VAD) is common...
  78. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..Our focus on molecular mechanisms will be on vitamin A regulation of genes for SP-B (direct regulation), VEGF (indirect regulation), and p53 (indirect regulation)...
  79. Vitamins help regulate the expression of trafficking receptors on T cells.
    Hekla Sigmundsdottir; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): The overall objective of this proposal is to test the hypothesis that vitamin A and vitamin D3 and their metabolites help program T cells with specific tissue- and microenvironmental-..
  80. REGULATION OF PROVITAMIN A CAROTENOID BIOSYNTHESIS IN MAIZE
    Eleanore T Wurtzel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamin A deficiency is a global health problem affecting close to 200 million children...
  81. IRON & VITAMIN A DEFICIENCY IN CHILDREN DUE TO H. PYLORI
    MOHAMMAD KHALED; Fiscal Year: 2000
    ..It is, therefore, hypothesized that H. pylori infection might be responsible for the iron and vitamin A deficiency in children which is highly prevalent in the third world countries, like India...
  82. VITAMIN A THERAPY IN PRETERM INFANTS: VACCINE RESPONSE
    Mark Ballow; Fiscal Year: 2002
    The role of vitamin A as an immune modulatory factor has been the focus of many studies both in animals and man. Epidemiologic studies emphasize that vitamin A is essential for supporting the immune system against infection...