tretinoin

Summary

Summary: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Top Publications

  1. ncbi Retinoic acid signalling during development
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Development 139:843-58. 2012
  2. ncbi Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
  3. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
  4. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
  5. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
  6. pmc The role of retinoic acid in tolerance and immunity
    Jason A Hall
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:13-22. 2011
  7. pmc Retinoic acid regulates sex-specific timing of meiotic initiation in mice
    Jana Koubova
    Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:2474-9. 2006
  8. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
  9. pmc Retinoic acid synthesis and signaling during early organogenesis
    Gregg Duester
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
    Cell 134:921-31. 2008
  10. ncbi Retinoid signaling determines germ cell fate in mice
    Josephine Bowles
    Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Science 312:596-600. 2006

Detail Information

Publications348 found, 100 shown here

  1. ncbi Retinoic acid signalling during development
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Development 139:843-58. 2012
    ..Here, we provide an overview of the RA biosynthesis, degradation and signalling pathways and review the main functions of this molecule during embryogenesis...
  2. ncbi Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
    ..Thus, inductive signals involved in normal pathways of neurogenesis can direct ES cells to form specific classes of CNS neurons...
  3. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    ..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
  4. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
    ..These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells...
  5. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion...
  6. pmc The role of retinoic acid in tolerance and immunity
    Jason A Hall
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:13-22. 2011
    ....
  7. pmc Retinoic acid regulates sex-specific timing of meiotic initiation in mice
    Jana Koubova
    Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:2474-9. 2006
    ..Because RA signaling regulates Stra8 expression in both embryonic ovaries and adult testes, this portion of the meiotic initiation pathway may be identical in both sexes...
  8. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
    ..Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators...
  9. pmc Retinoic acid synthesis and signaling during early organogenesis
    Gregg Duester
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
    Cell 134:921-31. 2008
    ..Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells...
  10. ncbi Retinoid signaling determines germ cell fate in mice
    Josephine Bowles
    Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Science 312:596-600. 2006
    ..Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate...
  11. ncbi Differentiation of mouse embryonic stem cells into a defined neuronal lineage
    Miriam Bibel
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    Nat Neurosci 7:1003-9. 2004
    ..As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics...
  12. ncbi Retinoic acid in the development, regeneration and maintenance of the nervous system
    Malcolm Maden
    MRC Centre for Developmental Neurobiology, fourth floor New Hunt s House, Guy s Campus, King s College London, London, SE1 1UL, UK
    Nat Rev Neurosci 8:755-65. 2007
    ..The data described here strongly suggest that RA could be used as a therapeutic molecule for the induction of axon regeneration and the treatment of neurodegeneration...
  13. pmc Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
    R W Depaolo
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Nature 471:220-4. 2011
    ..Altogether, these findings reveal an unexpected role for retinoic acid and IL-15 in the abrogation of tolerance to dietary antigens...
  14. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  15. ncbi Sonic hedgehog mediates the polarizing activity of the ZPA
    R D Riddle
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:1401-16. 1993
    ..Like the ZPA, Sonic hedgehog expression leads to the activation of Hox genes. Sonic hedgehog thus appears to function as the signal for antero-posterior patterning in the limb...
  16. ncbi Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research
    Yuen Ting Cheung
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neurotoxicology 30:127-35. 2009
    ..As a result, the real toxicity cannot be revealed in RA-differentiated cells. Therefore, undifferentiated SH-SY5Y is more appropriate for studying neurotoxicity or neuroprotection in experimental Parkinson's disease research...
  17. pmc Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro
    Qing Zhou
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    Biol Reprod 78:537-45. 2008
    ....
  18. pmc Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice
    Ericka L Anderson
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:14976-80. 2008
    ..Taken together with previous observations, our present findings indicate that, in both the male and female germ lines, meiosis is initiated through retinoic acid induction of Stra8...
  19. ncbi Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 115:1958-68. 2010
    ....
  20. ncbi Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension
    Ruth Diez del Corral
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    Neuron 40:65-79. 2003
    ..Our data demonstrate that FGF and RA pathways are mutually inhibitory and suggest that their opposing actions provide a global mechanism that controls differentiation during axis extension...
  21. ncbi Acute promyelocytic leukemia: from highly fatal to highly curable
    Zhen Yi Wang
    Shanghai Institute of Hematology and State Key Laboratory of Medical Genomics, Riu Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai, China
    Blood 111:2505-15. 2008
    ..In this article, we review the history of introduction of ATRA and ATO into clinical use and the mechanistic studies in understanding this model of cancer targeted therapy...
  22. ncbi Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    Satoshi Uematsu
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 9:769-76. 2008
    ..Our findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine...
  23. ncbi Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
    A Kakizuka
    Salk Institute for Biological Studies, La Jolla, California 92037
    Cell 66:663-74. 1991
    ..Treatment with RA would not only relieve this inhibition, but the activated PML-RAR protein may actually promote myelocyte differentiation...
  24. ncbi Retinoic acid in development: towards an integrated view
    Karen Niederreither
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 9:541-53. 2008
    ..Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine...
  25. pmc Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha
    Jason A Hall
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:435-47. 2011
    ....
  26. pmc Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis
    Shaun Mahony
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genome Biol 12:R2. 2011
    ..RAR is thought to bind the genome constitutively, and only induce transcription in the presence of the retinoid ligand. However, little is known about where RAR binds to the genome or how it selects target sites...
  27. ncbi Gene expression regulation by retinoic acid
    James E Balmer
    Institute for Nutrition Research, School of Medicine, University of Oslo, Oslo, Norway
    J Lipid Res 43:1773-808. 2002
    ..Most of the remaining 133 targets seem to be regulated indirectly, usually through a transcriptional intermediary, in the contexts studied so far (Category 0)...
  28. pmc Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells
    J Congleton
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Leukemia 26:1180-8. 2012
    ..This is the first evidence suggesting SFK inhibitors enhance ATRA-induced differentiation through a possible feedback loop involving KSR1-scaffolded c-Raf and ERK complexed with Lyn and CK2...
  29. ncbi All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
    Aiping Bai
    Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang 330006, China
    J Leukoc Biol 86:959-69. 2009
    ..RA down-regulates colon inflammatory responses in patients with IBD in vitro and in murine colitis in vivo, representing a potential therapeutic approach in IBD treatment...
  30. ncbi Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
    Pauline Isakson
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway
    Blood 116:2324-31. 2010
    ..Given the central role of the PML/RARA oncoprotein in APL pathogenesis, this study highlights an important role of autophagy in the development and treatment of this disease...
  31. ncbi Specification of motoneurons from human embryonic stem cells
    Xue Jun Li
    Nat Biotechnol 23:215-21. 2005
    ....
  32. ncbi Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells
    Miriam Bibel
    Novartis Institutes for BioMedical Research, Neuroscience Research, CH 4002 Basel, Switzerland
    Nat Protoc 2:1034-43. 2007
    ..At least 2 weeks are required from starting ES cell culture until plating progenitors and differentiating neurons establish synaptic transmission within about 10 days...
  33. ncbi From carrot to clinic: an overview of the retinoic acid signaling pathway
    Maria Theodosiou
    Institut de Génomique Fonctionnelle de Lyon, Université de Lyon Université Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Cell Mol Life Sci 67:1423-45. 2010
    ..Moreover, we discuss the origin and diversification of the retinoid pathway, which are important factors for understanding the evolution of ligand-specificity among retinoid receptors...
  34. pmc Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
    Xiaohui Zhou
    Division of Rheumatology, University of South California, Los Angeles, CA 90033, USA
    J Immunol 185:2675-9. 2010
    ..We suggest that nTregs treated with atRA may represent a novel treatment strategy to control established chronic immune-mediated inflammatory diseases...
  35. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
    ..This review summarizes the considerable amount of knowledge generated on these receptors...
  36. pmc A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity
    Karina Pino-Lagos
    Department of Microbiology and Immunology, Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Exp Med 208:1767-75. 2011
    ..These findings provide a new perspective of the role of RA as a mediator directly controlling CD4(+) T cell differentiation and immunity...
  37. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
  38. pmc Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunity 29:758-70. 2008
    ..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA...
  39. ncbi FGF9 suppresses meiosis and promotes male germ cell fate in mice
    Josephine Bowles
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Dev Cell 19:440-9. 2010
    ....
  40. ncbi Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 30:626-35. 2009
    ....
  41. ncbi Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies
    Fernanda Martins Lopes
    Department of Biochemistry, ICBS UFRGS, Porto Alegre RS, Brazil
    Brain Res 1337:85-94. 2010
    ..Our data suggest that SH-SY5Y cells differentiated by 7 days with the protocol described here represent a more suitable experimental model for studying the molecular and cellular mechanisms underlying the pathophysiology of PD...
  42. pmc Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor
    Schoen W Kruse
    Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, Michigan, USA
    PLoS Biol 6:e227. 2008
    ....
  43. ncbi Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis
    Vanessa Ribes
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U 596, CNRS UMR 7104, Universite Louis Pasteur, 1 rue Laurent Fries, Illkirch, BP 10142 F 67400, France
    Dev Biol 321:470-81. 2008
    ..Our data thus support a model where signal integration at the level of a single enhancer constitutes a key mechanism to control the onset of neurogenesis...
  44. pmc Regional differentiation of retinoic acid-induced human pluripotent embryonic carcinoma stem cell neurons
    Dennis E Coyle
    Department of Anesthesiology, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16174. 2011
    ..It is proposed that understanding the regional differentiation bias of neurons derived from pluripotent stem cells will facilitate their successful integration into existing neuronal networks within the CNS...
  45. ncbi Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Science 308:563-6. 2005
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos...
  46. ncbi Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos
    Julien Vermot
    Stowers Institute for Medical Research, 1000E 50th Street, Kansas City, Missouri 64110, USA
    Nature 435:215-20. 2005
    ..Our data indicate that RA is important in buffering the lateralizing influence of the left-right machinery, thus permitting synchronization of the development of the two embryonic sides...
  47. pmc Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
    Craig L Maynard
    Department of Pathology, University of Alabama at Birmingham, AL 35294, USA
    J Exp Med 206:343-57. 2009
    ....
  48. ncbi Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid
    Y Alsayed
    Section of Hematology-Oncology, Department of Medicine, University of Illinois and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 276:4012-9. 2001
    ..Altogether, our findings demonstrate that the Rac1/p38 MAP kinase pathway is activated in a RA-dependent manner and exhibits negative regulatory effects on the induction of differentiation...
  49. pmc Physiological insights into all-trans-retinoic acid biosynthesis
    Joseph L Napoli
    University of California, Berkeley, CA, USA
    Biochim Biophys Acta 1821:152-67. 2012
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism...
  50. ncbi Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
    Rihab Nasr
    Université de Paris 7 CNRS UMR 7151, Equipe labellisée N degrees 11 Ligue Nationale Contre le Cancer, Service de Biochimie, Hopital St Louis, Paris Cedex 10, France
    Nat Med 14:1333-42. 2008
    ..Therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells...
  51. ncbi Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1
    Masumi Suzui
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 62:3997-4006. 2002
    ..These novel effects of ACR provide further evidence that ACR may be a valuable agent in the chemoprevention and therapy of hepatoma and possibly other human malignancies...
  52. ncbi Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos
    Yanfeng Lin
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 322:1685-7. 2008
    ..Within a brief developmental window, Dazl-expressing germ cells in both XX and XY embryos actively acquire the ability to interpret RA as a meiosis-inducing signal...
  53. pmc Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics
    Marco A Mendoza-Parra
    Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM Université de Strasbourg, Illkirch Cedex, France
    Mol Syst Biol 7:538. 2011
    ..Our analysis provides a dynamic view of RA signalling during cell differentiation, reveals RAR heterodimer dynamics and promiscuity, and predicts decisions that diversify the RA signal into distinct gene-regulatory programs...
  54. pmc In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia
    Marie Claude Guillemin
    CNRS UPR 9051, Laboratoire Associé au Comité de Paris de la Ligue contre le Cancer, affilié à l Université de ParisVII, France
    J Exp Med 196:1373-80. 2002
    ....
  55. ncbi In vitro derivation of functional insulin-producing cells from human embryonic stem cells
    Wei Jiang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    Cell Res 17:333-44. 2007
    ..Our new method provides a promising in vitro differentiation model for studying the mechanisms of human pancreas development and illustrates the potential of using human ES cells for the treatment of type I diabetes mellitus...
  56. pmc MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation
    Sudipto Das
    Department of Cancer Genetics, Royal College of Surgeons, Ireland
    Cancer Res 70:7874-81. 2010
    ..Our findings illustrate the plasticity and dynamic nature of the epigenome during cancer cell differentiation...
  57. ncbi A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification
    Bennett G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 40:81-95. 2003
    ..Moreover, joint exposure of neural progenitors to retinoids and FGFs suffices to induce motor neuron differentiation in a Shh-independent manner...
  58. pmc Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin
    Karen A M Kennedy
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    BMC Biol 7:67. 2009
    ..Thus, the purpose of this study is to examine the molecular mechanisms by which RA enhances skeletal myogenesis and interacts with Wnt and BMP4 signalling during P19 or mouse embryonic stem (ES) cell differentiation...
  59. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994
    ..We discuss several possibilities that may account for the apparent functional redundancy observed amongst retinoic acid receptors during embryogenesis...
  60. pmc Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
    Sheng Xiao
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:2277-84. 2008
    ....
  61. pmc GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity
    Aya Yokota
    Laboratory of Biodefense Research, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki shi, Kagawa, Japan
    Int Immunol 21:361-77. 2009
    ..GM-CSF(+)CD11c(-)F4/80(+) cells existed constitutively in the intestinal tissues. The results suggest that GM-CSF and RA itself are pivotal among multiple microenvironment factors that enable intestinal DCs to produce RA...
  62. pmc Retinoid pathway and cancer therapeutics
    Nathan Bushue
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Adv Drug Deliv Rev 62:1285-98. 2010
    ..This review summarizes our current understanding of how retinoids are processed and act with an emphasis on the application of retinoids in cancer treatment and prevention...
  63. pmc Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo
    Swantje I Hammerschmidt
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    J Exp Med 205:2483-90. 2008
    ..These results demonstrate a hitherto unrecognized contribution of stromal cell delivered signals, including RA, on the imprinting of tissue tropism in vivo...
  64. pmc Nanos2 suppresses meiosis and promotes male germ cell differentiation
    Atsushi Suzuki
    Department of Genetics, SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Genes Dev 22:430-5. 2008
    ..We also demonstrate that Nanos2 activates a male-specific genetic program, which is supported by the inhibition of meiosis and the induction of male-type differentiation in female germ cells following the forced expression of Nanos2...
  65. ncbi Role of the histone deacetylase complex in acute promyelocytic leukaemia
    R J Lin
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 391:811-4. 1998
    ..Our findings suggest that oncogenic RARs mediate leukaemogenesis through aberrant chromatin acetylation, and that pharmacological manipulation of nuclear receptor co-factors may be a useful approach in the treatment of human disease...
  66. pmc All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor
    Daniel C Berry
    Department of Pharmacology, Case Western Reserve University, 10900 Euclid Ave, SOM W333, Cleveland, OH 44106, USA
    Mol Cell Biol 29:3286-96. 2009
    ..By targeting two nuclear receptors, RA may be a uniquely efficacious agent in the therapy and prevention of the metabolic syndrome...
  67. ncbi Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids
    J P Liu
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 32:997-1012. 2001
    ....
  68. pmc Onset of meiosis in the chicken embryo; evidence of a role for retinoic acid
    Craig A Smith
    Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics, Royal Children s Hospital, Melbourne, 3052, Australia
    BMC Dev Biol 8:85. 2008
    ..Here we report the molecular analysis of meiosis onset in the chicken model and provide evidence for conserved regulation by retinoic acid...
  69. pmc Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells
    Sita Aggarwal
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Biol Cell 17:566-75. 2006
    ..This noncanonical RA signaling pathway may play an important role in mediating early biological effects in the mucociliary differentiation of bronchial epithelia...
  70. ncbi All trans retinoic acid and cancer
    - Siddikuzzaman
    Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore 641 114, Tamil Nadu, India
    Immunopharmacol Immunotoxicol 33:241-9. 2011
    ..This review helps to understand in details about the ATRA and its role on cancer and it is predicted that modulating the activity of ATRA will soon provide novel prevention and treatment approaches for the cancer patients...
  71. pmc Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells
    T Angrisano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale CNR, Università degli Studi di Napoli Federico II 80131 Naples, Italy
    Nucleic Acids Res 39:1993-2006. 2011
    ....
  72. pmc All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients
    Noweeda Mirza
    H Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 66:9299-307. 2006
    ..ATRA treatment did not result in significant toxicity and it could be tested in therapeutic combination with cancer vaccines...
  73. pmc ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells
    Aurore Trocoli
    INSERM U916 VINCO, Institut Bergonie, Bordeaux, France
    Autophagy 7:1108-14. 2011
    ..This finding may help to elucidate the mechanisms involved in ATRA resistance of APL patients, and in the ATRA syndrome caused by an accumulation of mature APL cells...
  74. ncbi Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells
    Yanfen Fang
    Institute of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China
    Mol Carcinog 50:24-35. 2011
    ....
  75. pmc Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation
    Ming Fu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 137:631-40. 2010
    ....
  76. ncbi Differentiation therapy of acute myeloid leukemia: past, present and future
    Kevin Petrie
    Institute of Cancer Research, Sutton, UK
    Curr Opin Hematol 16:84-91. 2009
    ....
  77. ncbi Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells
    Yohei Okada
    Department of Physiology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Dev Biol 275:124-42. 2004
    ....
  78. pmc Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages
    Santhakumar Manicassamy
    Emory Vaccine Center and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Semin Immunol 21:22-7. 2009
    ..Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes...
  79. ncbi Nuclear retinoic acid receptors: conductors of the retinoic acid symphony during development
    Eric Samarut
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM, U596 CNRS, UMR7104 Université de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    Mol Cell Endocrinol 348:348-60. 2012
    ..It appears that RARs are the conductors of the RA signaling symphony through controlling the dynamics and the coordination of the different players and development steps...
  80. ncbi Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation
    Clotilde Billottet
    Centre for Cell Signalling, Queen Mary University of London, Institute of Cancer, Barts and the London School of Medicine, John Vane Science Centre University College London, London, United Kingdom
    Cancer Res 69:1027-36. 2009
    ..Addition of PI3K inhibitors to induction treatment regimens may provide therapeutic benefit...
  81. ncbi Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells
    Christian M Metallo
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Stem Cells 26:372-80. 2008
    ..These findings suggest that RA plays an important role in epithelial differentiation of hESCs...
  82. ncbi Regulation of retinoic acid signaling during lung morphogenesis
    S Malpel
    Pulmonary Center Boston University School of Medicine, Boston, MA 02118, USA
    Development 127:3057-67. 2000
    ..Our study illustrates the importance of regional mechanisms that control RA availability and utilization for correct expression of pattern regulators and normal morphogenesis during lung development...
  83. ncbi A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma
    R Chan
    National Skin Centre, 1 Mandalay Road, Singapore 308205
    Br J Dermatol 159:697-703. 2008
    ..Melasma is an acquired, chronic hypermelanosis for which therapy remains a challenge...
  84. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
    ..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb...
  85. pmc Regulation of mouse embryonic stem cell neural differentiation by retinoic acid
    Mijeong Kim
    Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 328:456-71. 2009
    ..Transcriptional profiling indicates a substantial representation of transit amplifying neuroblasts in SFD cultures not exposed to RA...
  86. ncbi Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2)
    P Bouillet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
    Dev Biol 170:420-33. 1995
    ..We also report the sequence and expression pattern in mouse embryos and adult tissues of one of these novel RA-inducible genes, Stra1, and show that it corresponds to the mouse ligand for the Cek5 receptor protein-tyrosine kinase...
  87. pmc Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
    E M Rego
    Department of Human Genetics, Molecular Biology Program, and Department of Medicine, Molecular Therapeutics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:10173-8. 2000
    ....
  88. pmc Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene
    M Oulad-Abdelghani
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Illkirch, France
    J Cell Biol 135:469-77. 1996
    ..Thus, Stra8 protein may play a role in the premeiotic phase of spermatogenesis...
  89. ncbi Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures
    J Takahashi
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurobiol 38:65-81. 1999
    ..In combination, these sequential effects were sufficient to stimulate stem cell-derived progenitors to differentiate into neurons displaying a variety of transmitter phenotypes...
  90. ncbi All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol
    Martin S Tallman
    Northwestern University, Feinburg School of Medicine, Department of Medicine, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    Blood 100:4298-302. 2002
    ..The improvement in outcome with ATRA in APL was maintained with long-term follow-up...
  91. ncbi Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation
    Felix Schambach
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Immunol 37:2396-9. 2007
    ..Specific agonists of RARalpha could, therefore, be considered candidates for the treatment of autoimmunity...
  92. pmc Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
    Sheila M O'Byrne
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:35647-57. 2005
    ..The fatty acyl composition of these (chylomicron) retinyl esters suggests that they are synthesized via an acyl-CoA-dependent process suggesting the existence of a physiologically significant acyl-CoA:retinol acyltransferase...
  93. ncbi Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia
    Doyeob Kim
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Soc Nephrol 16:3527-34. 2005
    ..These methods may facilitate the large-scale culture of renal epithelial precursor cells for a variety of applications...
  94. ncbi Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake
    Francisco Felipe
    Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Crta Valldemossa km 7 5, 07122 Palma de Mallorca, Spain
    Biochim Biophys Acta 1740:258-65. 2005
    ..Reduction of leptin levels by specific nutrients is of potential interest from a clinical point of view...
  95. pmc Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation
    Natalia Molotkova
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 122:145-55. 2005
    ..An important concept to emerge from our studies is that the somitic mesodermal RA signal acts in the neuroectoderm but not mesoderm to generate a spinal cord fate...
  96. ncbi 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
    R A Heyman
    Ligand Pharmaceuticals, Inc, San Diego, California 92121
    Cell 68:397-406. 1992
    ..The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways...
  97. pmc High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation
    Seung G Kang
    Department of Comparative Pathobiology, Laboratory of Immunology and Hematopoiesis, Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    Gastroenterology 137:1391-402.e1-6. 2009
    ....
  98. pmc Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism
    L Feng
    Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Dev Biol 338:1-14. 2010
    ..Dhrs3a is thus an RA-induced feedback inhibitor of RA biosynthesis. We conclude that retinaldehyde availability is an important level at which RA biosynthesis is regulated in vertebrate embryos...
  99. pmc Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines
    Jens Nolting
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:2131-9. 2009
    ..Interleukin (IL)-6 strongly reduced RAR alpha expression levels such that a deficiency of the predominant RAR alpha 1 isoform leaves too little RAR alpha 2 for RA to inhibit the generation of Th17 cells in the presence of IL-6...
  100. ncbi Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells
    Dianne Robert Soprano
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Vitam Horm 75:69-95. 2007
    ..However, the exact molecule events that lead from a pluripotent stem cell to a fully differentiated cell following RA treatment are yet to be determined...
  101. pmc Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity
    Bita Maghsoodi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:16015-20. 2008
    ..Taken together, our results provide a direct link between dendritically localized RARalpha and local GluR1 synthesis in RNA granules during RA-mediated synaptic signaling in homeostatic synaptic plasticity...

Research Grants68

  1. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..The studies would also lead to the identification of biomarkers that would be useful in clinical trials. ..
  2. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ....
  3. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ....
  4. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2013
    ..Many cancer chemoprevention trials in humans have not been successful, pointing to the need to carry out more fundamental studies and to test the idea that combination therapy may be essential for successful chemoprevention. ..
  5. The PPAR-delta pathway in neural function and Hungtington's disease neuropatholog
    Albert R La Spada; Fiscal Year: 2013
    ....
  6. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
    ..abstract_text> ..
  7. Alcohol-Induced Epigenetic Changes in Stem Cells
    Lorraine J Gudas; Fiscal Year: 2013
    ..Moreover, unlike genetic mutations that change the DNA sequence and are generally permanent, epigenetic changes can be reversed and therefore are reasonable targets for therapies to treat alcohol-induced tissue injury. ..
  8. Rapid Label-Free Detection of Acute Promyelocytic Leukemia
    Lydia L Sohn; Fiscal Year: 2012
    ..Senior Personnel, George Anwar, Ph.D. at UC Berkeley will lead in the software and hardware design and packaging of the device for point-of-care. ..
  9. Therapeutic Immunoregulation Mediated by TGF-beta-induced iTregs in Autoimmune Ar
    Song Guo Zheng; Fiscal Year: 2013
    ..If successful, this project will also have a direct clinical relevance and possibly provide a novel approach to treat RA and other autoimmune diseases which may not have the severe side effect(s) characteristic of current therapies. ..
  10. Interplay among NKT cell subsets in alcoholic liver disease
    Vipin Kumar; Fiscal Year: 2013
    ....
  11. Retinoic Acid Modulation for Scleroderma
    BERT J W M OEHLEN; Fiscal Year: 2012
    ..We propose here to also evaluate their activity in preclinica animal models of SSc. We thus aim to generate critical proof of concept data that could warrant their further preclinical and clinical development for SSc. ..
  12. Short-Chain Dehydrogenases in Retinol/Sterol Metabolism
    Natalia Y Kedishvili; Fiscal Year: 2013
    ....
  13. Retinoid receptor antagonists as novel male contraceptives
    Debra J Wolgemuth; Fiscal Year: 2013
    ..Non-hormonal strategies for male contraception would provide health benefits to couples desiring alternative family planning approaches and to over-populated countries world-wide. ..
  14. Targeting multiple skin cancer pathways using citrus auraptene and ATRA
    J Michael Mathis; Fiscal Year: 2012
    ..The tumorigenic properties of the resulting pathway suppressed cells will be determined. ..
  15. CD38 Pretargeted Radioimmunotherapy for Myeloma
    Oliver W Press; Fiscal Year: 2013
    ..We predict synergistic anti-tumor activity with combinations of PRIT and lenalidomide or bortezomib. We anticipate rapid translation of the results of these preclinical experiments into our clinical RIT program for MM. ..
  16. Treatment for alcoholic liver disease
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..We intend to develop of small molecule inhibitors of retinoic acid 4- hydroxylase that can elevate the body's ATRA levels as a potential therapeutic for alcoholic liver disease. ..
  17. Maternal Smoking and the Developing Lung
    Kathleen J Haley; Fiscal Year: 2010
    ..Addressing these questions will provide insight into the role early developmental events have in causing adult lung disease and will suggest novel therapeutic interventions to protect the lung from the effects of maternal smoking. ..
  18. BP1 and Nuclear Hormone Signaling in Breast Cancer
    JOSEPH PINZONE; Fiscal Year: 2009
    ..Schwartz, Fontana, and Ascensao will provide overarching scientific and career guidance and independent ongoing peer review. Finally, Dr. Schaffner will mentor my training in the responsible conduct of research. ..
  19. Signals for Post-pneumonectomy Compensatory Lung Growth
    Connie C W Hsia; Fiscal Year: 2013
    ..Results have important basic and clinical implications for the re-initiation of lung growth in human chronic lung disease. ..
  20. Sulfatide-reactive type II NKT cells: repertoire and function
    Vipin Kumar; Fiscal Year: 2013
    ....
  21. Viral Infection and Impairment of Immune Tolerance
    Prabir Ray; Fiscal Year: 2012
    ..Aim 3. Examine the ability of aerosolized liposome-encapsulated ATRA to restore Treg function and airway tolerance in RSV-infected lungs. ..
  22. Cytokine modulated model growth inhibitory mechanisms
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..The studies proposed in this application will define how tumor- specific dysfunctions in GRIM-19 affect the functioning of this new growth regulatory pathway. ..
  23. Ethanol effects on retinoic acid function in embryo hippocampus
    Joseph L Napoli; Fiscal Year: 2013
    ....
  24. Topoisomerase ll Beta in Myeloid Differentiation by Retionids
    RAM N GANAPATHI; Fiscal Year: 2010
    ..In the long term, identification of these targets would assist in the development of novel strategies for treatment of AML secondary to myelodysplastic syndrome. ..
  25. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..The concept of double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drugs for the treatment of ovarian cancer. ..
  26. Effects of Xenobiotics on CYP26 Activity and Retinoic Acid Homeostasis
    Nina Isoherranen; Fiscal Year: 2012
    ..This proposal aims at characterizing interactions between xenobiotics and retinoic acid metabolizing CYP26 enzymes that alter retinoic acid metabolism and clearance and can lead to adverse effects. ..
  27. Genetic Rescue of Retinoid-Induced Dysfunction
    Pilar Ruiz-Lozano; Fiscal Year: 2013
    ..Completion of this proposal will set up the groundwork for novel therapies to cardiovascular disease. ..
  28. Vitamin A-Mediated Protection in Measles
    Diane E Griffin; Fiscal Year: 2013
    ....
  29. Novel Targeted Therapy for AML
    Kapil Bhalla; Fiscal Year: 2013
    ..Overall, these aims will establish NPM1 as a 'druggable'target and pave the way for performing high throughput screening and development of novel compounds that target NPM1 for the therapy of AML expressing mtNPM1. ..
  30. T cell plasticity in atherosclerosis
    Elena V Galkina; Fiscal Year: 2013
    ....
  31. Discovering small molecules that overcome differentiation arrest in acute myeloid
    David B Sykes; Fiscal Year: 2012
    ..A novel model system of AML has been devised to identify novel compounds which trigger leukemic cells to resume the normal process of maturation, thereby losing their proliferative and leukemic potential. Page 1 of 1 ..
  32. REGULATION OF SCLERAL GROWTH AND REMODELING IN MYOPIA
    Jody A Summers; Fiscal Year: 2013
    ..Ultimately, such knowledge will provide multiple avenues for the development of new, specifically targeted pharmacologic strategies for the treatment of myopia. ..
  33. Innate Immunity in Acne Vulgaris
    Jenny J Kim; Fiscal Year: 2013
    ....
  34. Hepatic Lipid Mobilization by Nuclear Hormone Receptors
    Yoon Kwang Lee; Fiscal Year: 2013
    ....
  35. Nanoparticle Drug Delivery in Post-Pneumonectomy Compensatory Lung Growth
    Kytai Truong Nguyen; Fiscal Year: 2013
    ..Results will impact fundamental concepts of lung regeneration-repair, bridge a key knowledge gap in the manipulation of lung growth, and are immediately translatable to the bedside. ..
  36. Regulatory T-Cells and Chronic Colitis
    Matthew B Grisham; Fiscal Year: 2011
    ..Data obtained from these studies may provide the necessary data to begin to develop a Treg-based therapeutic strategy for the treatment of patients with inflammatory bowel disease. ..
  37. Wnt signaling and hematopoietic stem cells
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..Studies to be undertaken will establish an optimized Wnt signaling system and evaluate stem cell responsiveness as a function Wnt association with specialized nanoparticles. ..
  38. Functional characterization of the long non-coding RNA Scirocco in development an
    FRANK U SAUER; Fiscal Year: 2013
    ....
  39. The Role of the Microbiome in the Development/Prevention of Food Allergies
    Gary B Huffnagle; Fiscal Year: 2011
    ..The data from this proposal will increase our understanding of the mechanisms connecting the indigenous microbiota and food allergies, including the mechanisms of probiosis to treat food allergies. ..
  40. Regulation of synaptic transmission by retinoic acid signaling
    Lu Chen; Fiscal Year: 2013
    ....
  41. MECHANISMS OF BILE SECRETION AND CHOLESTASIS
    JAMES LORENZEN BOYER; Fiscal Year: 2013
    ..AIM #3: Comparative studies of bile acid transport in marine vertebrates. We will continue to utilize marine animals as comparative models for bile acid transporters in the enterohepatic circulation. ..
  42. ANALOG STUDIES OF 4-HPR AND ITS GLUCURONIDE
    Robert W Curley; Fiscal Year: 2013
    ..A clearer understanding of how these promising molecules function would further enhance our ability to develop and exploit them. ..
  43. Oral Immune Modulatory Adjuvants for Treatment of Colorectal Carcinoma
    Nejat K Egilmez; Fiscal Year: 2012
    ..e. controlled-release formulations of anti-IL-9 antibody and Masitinib, are evaluated in the same models. If successful, these studies can lead to a new therapeutic paradigm in the management of CRC. ..
  44. Dendritic Cell Manipulation: A Novel Therapeutic for Inflammatory Bowel Disease
    Jesus Rivera-Nieves; Fiscal Year: 2013
    ..abstract_text> ..
  45. IN VIVO PREVENTION OF MURINE GVHD
    Bruce R Blazar; Fiscal Year: 2013
    ..Lastly, we will determine whether our preferred GVHD approach(es) affect graft-versus-leukemia (GVL) responses. When done, we will have developed new therapies to prevent GVHD and maintain GVL. ..
  46. Retinoic acid and CRABP-II in regulation of post transcriptional gene silencing
    Noa Noy; Fiscal Year: 2013
    ..The studies will also investigate the possibility that suppression o mammary carcinoma growth by CRABP-II is mediated in part through the ability of the protein to regulate mRNA stability. ..
  47. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2013
    ....
  48. Characterization of SLE-susceptibility loci on mouse chromosome 1
    Laurence Morel; Fiscal Year: 2013
    ..We expect these results to delineate two novel regulatory pathways of T cell effector functions, to provide novel biomarkers for autoreactive T cells as well as identify lupus therapeutic targets. ..
  49. Novel differentiation therapy for AML
    Mukesh Agarwal; Fiscal Year: 2009
    ..As the current AML therapeutics have low efficacy and high toxicities, there is a significant need for new therapies for AML. ..
  50. Retinoic Acid Paradox and Promyelocitic Leukemia
    Ethan Dmitrovsky; Fiscal Year: 2013
    ..This revised NIH R0-1 renewal application seeks to elucidate the precise role of G0S2 in RA differentiation response in APL. These findings are relevant to retinoid therapy of other human malignancies. ..
  51. RNAi screen for chromatin regulators of differentiation in Acute Myeloid Leukemia
    M Andres Blanco; Fiscal Year: 2013
    ..Successful identification and molecular understanding of such enzymes would directly suggest their candidacy as potential therapeutic targets for non-APL AML. ..
  52. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  53. Bioequivalence of topical drug products: in vitro - in vivo correlations
    Audra L Stinchcomb; Fiscal Year: 2013
    ..A systematic examination of several key classes of topical drug products will be undertaken including, but not limited to lidocaine, triamcinolone acetonide, tretinoin, acyclovir and metronidazole.
  54. TAS::75 0849::TAS TOPIC 255 DEVELOPMENT OF A TARGETED THERAPY FOR ACUTE MYELOID
    DR MUKESH AGARWAL; Fiscal Year: 2011
    ..In this application, we will test the clinical utility of this novel agent for AML using mouse model systems. Provide key ..
  55. Identification of Factors Influencing Climbing Fiber Neuron Fate in the Dorsal Hi
    REBECCA LANDSBERG; Fiscal Year: 2009
    ..The experiments proposed in this study are aimed at uncovering the molecular signals underlying the development and differentiation of neurons of the inferior olive. ..
  56. Controlled Release Vascular Grafts
    ANTONIO WEBB; Fiscal Year: 2009
    ..VesselTek Biomedical aims to create controlled drug release POC- ePTFE vascular grafts to improve the patency of bypass grafts and reduce the incidence of limb amputation caused by severe peripheral artery disease. ..
  57. PREDICTION AND MODIFICATION OF MELANOMA RISK
    DuPont Guerry; Fiscal Year: 2000
    ..Project 2 utilizes a randomized trial of topical tretinoin and 4-HPR (fenretinide) to test chemoprevention in another cohort with dysplastic nevi...
  58. Natural product-derived differentiation agents for AML
    Mukesh Kumar Agarwal; Fiscal Year: 2012
    ..As differentiation therapies are able to treat leukemia without the necessity for overt cytotoxicity, this work has the potential to lead to much needed more efficacious, less toxic, and better tolerated therapy for patients with AML. ..
  59. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..The relative predictive ability of the markers will be assessed using multiple logistic regression along with other potential predictive variables including the expression of RAR and/or RXR. ..
  60. DIFFERENTIATION AND APOPTOSIS IN MALIGNANT NEUROBLASTOMA
    Swapan Ray; Fiscal Year: 2009
    ..Success of our therapeutic strategy can form a basis for treatment of neuroblastoma in humans. ..
  61. PLACENTAL TOXICOLOGY
    Richard Miller; Fiscal Year: 1992
    ..that the human placenta (both early and term) can metabolize retinoids, in particular isotretinoin (Accutane) to tretinoin. Such metabolism by the human placenta may partially account for the species differences between rodents and ..
  62. Gene Regulation for Drug Targeting in AML
    Manohar Ratnam; Fiscal Year: 2009
    ..The studies should provide a solid foundation for designing clinical trials of new AML therapies and should also elucidate a fundamentally novel mechanism of gene regulation by retinoid receptors. ..
  63. ARSENIC TRIOXIDE TREATMENT OF LYMPHOPROLIFERATIVE DISORD
    Samuel Waxman; Fiscal Year: 2003
    ..Should our laboratory study identify agents or schedules that enhance the response to As203, we will use them to appropriately modify the initial phase II pilot study. ..
  64. GYNECOLOGIC MALIGNANCIES--NOVEL PHASE II AGENTS
    Scott Wadler; Fiscal Year: 2000
    ....
  65. ACTION OF RETINOIDS ON MYELOID LEUKEMIA
    H Koeffler; Fiscal Year: 1993
    ..Our findings may have clinical applications for certain leukemias...
  66. Mechanisms of Inner Ear Malformation by Retinoic Acid
    Dorothy Frenz; Fiscal Year: 2005
    ....
  67. HPV INTEGRATION AS A BIOMARKER FOR CIN BEHAVIOR
    Wayne Lancaster; Fiscal Year: 2003
    ..abstract_text> ..
  68. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2006
    ..Aim 4) To investigate whether IGFBP-6 expression increases in the bronchial epithelium of patients treated with retinoids. ..