retinoids

Summary

Summary: A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.

Top Publications

  1. ncbi Overview of retinoid metabolism and function
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Neurobiol 66:606-30. 2006
  2. pmc Retinoids regulate stem cell differentiation
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA
    J Cell Physiol 226:322-30. 2011
  3. pmc Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage
    William S Blaner
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Biochim Biophys Acta 1791:467-73. 2009
  4. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
  5. ncbi Retinoids, retinoic acid receptors, and cancer
    Xiao Han Tang
    Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA
    Annu Rev Pathol 6:345-64. 2011
  6. pmc Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:16182-7. 2006
  7. pmc Hepatic metabolism of retinoids and disease associations
    Yohei Shirakami
    Department of Medicine, College of Physcians and Surgeons, Columbia University, 630 W, 168th St, New York, NY 10032, USA
    Biochim Biophys Acta 1821:124-36. 2012
  8. pmc Vitamin A metabolism: an update
    Diana N D'Ambrosio
    Department of Medicine and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nutrients 3:63-103. 2011
  9. ncbi The role of retinoids and retinoic acid receptors in normal hematopoiesis
    S J Collins
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Leukemia 16:1896-905. 2002
  10. ncbi Retinoids in cancer therapy and chemoprevention: promise meets resistance
    Sarah J Freemantle
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Oncogene 22:7305-15. 2003

Detail Information

Publications307 found, 100 shown here

  1. ncbi Overview of retinoid metabolism and function
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Neurobiol 66:606-30. 2006
    b>Retinoids (vitamin A) are crucial for most forms of life...
  2. pmc Retinoids regulate stem cell differentiation
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA
    J Cell Physiol 226:322-30. 2011
    b>Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert profound effects on development, and complement cancer chemotherapeutic regimens...
  3. pmc Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage
    William S Blaner
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Biochim Biophys Acta 1791:467-73. 2009
    ..Collectively, the available information suggests that HSC lipid droplets are specialized organelles for hepatic retinoid storage and that loss of HSC lipid droplets may contribute to the development of hepatic disease...
  4. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
    ..The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and ..
  5. ncbi Retinoids, retinoic acid receptors, and cancer
    Xiao Han Tang
    Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA
    Annu Rev Pathol 6:345-64. 2011
    b>Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids...
  6. pmc Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:16182-7. 2006
    ..These findings link four factors that have been posited as being associated with AMD: inflammation, oxidative damage, drusen, and RPE lipofuscin...
  7. pmc Hepatic metabolism of retinoids and disease associations
    Yohei Shirakami
    Department of Medicine, College of Physcians and Surgeons, Columbia University, 630 W, 168th St, New York, NY 10032, USA
    Biochim Biophys Acta 1821:124-36. 2012
    ..This article is part of a Special Issue entitled Retinoid and Lipid Metabolism...
  8. pmc Vitamin A metabolism: an update
    Diana N D'Ambrosio
    Department of Medicine and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nutrients 3:63-103. 2011
    b>Retinoids are required for maintaining many essential physiological processes in the body, including normal growth and development, normal vision, a healthy immune system, normal reproduction, and healthy skin and barrier functions...
  9. ncbi The role of retinoids and retinoic acid receptors in normal hematopoiesis
    S J Collins
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Leukemia 16:1896-905. 2002
    ..that characterize human acute promyelocytic leukemia (APL) has led to numerous studies assessing the role of retinoids and the retinoic acid receptors (RARs) in the regulation of normal hematopoiesis...
  10. ncbi Retinoids in cancer therapy and chemoprevention: promise meets resistance
    Sarah J Freemantle
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Oncogene 22:7305-15. 2003
    b>Retinoids (natural and synthetic derivatives of vitamin A) signal potent differentiation and growth-suppressive effects in diverse normal, premalignant, and malignant cells...
  11. ncbi Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H
    Syed M Noorwez
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 279:16278-84. 2004
    ..The implications of this study for treating retinitis pigmentosa and other protein conformational disorders are discussed...
  12. pmc Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila
    Adrian Halme
    Department of Molecular and Cell Biology, University of California, Berkeley, 365 LSA, MC 3200, Berkeley, CA 94720, USA
    Curr Biol 20:458-63. 2010
    ..Our findings demonstrate that retinoid biosynthesis in Drosophila is important for the maintenance of a condition that is permissive for regenerative growth...
  13. ncbi Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signalling
    Nicole Etchamendy
    CNRS UMR 5106, Lab Neurosciences Cognitives, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Behav Brain Res 145:37-49. 2003
    Vitamin A and its derivatives, the retinoids, have recently been reported to be implicated in the synaptic plasticity of the hippocampus and in cognitive functions...
  14. ncbi The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells
    J R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 41:1981-9. 2000
    ..To determine whether the lipofuscin fluorophore A2E participates in blue light-induced damage to retinal pigmented epithelial (RPE) cells...
  15. ncbi International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
    ..Indeed, multiple questions about the actual biological role of RXRs and the existence of an endogenous ligand have still to be answered...
  16. pmc Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e32846. 2012
    The retinoids, the natural or synthetic derivatives of Vitamin A (retinol), are essential for the normal development of prostate and have been shown to modulate prostate cancer progression in vivo as well as to modulate growth of several ..
  17. ncbi Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells
    Tetsuro Sano
    Pharmaceutical Research Laboratories, Nikken Chemicals Co, Saitama, Japan
    Nutr Cancer 51:197-206. 2005
    ..These results suggest that NIK-333 is a promising drug for the chemoprevention of HCC by uniquely suppressing the early events of hepatocarcinogenesis, that is, development of both oval-like cells and fibrogenesis...
  18. pmc Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription
    K Toth
    Apoptosis and Genomics Research Group, Department of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, University of Debrecen, Nagyerdei krt 98, Debrecen, Hungary
    Cell Death Differ 18:783-92. 2011
    ..Phosphorylation of PI-PLC was not affected. Besides thymocytes, retinoids also promoted glucocorticoid-induced apoptosis of various T-cell lines, suggesting that they could be used in ..
  19. ncbi DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 44:2245-51. 2003
    ..This study was designed to determine whether DNA is a target of the cellular damage...
  20. pmc Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver
    Matthew L Batten
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:10422-32. 2004
    ..We conclude that Lrat-/- mice may serve as an animal model with early onset severe retinal dystrophy and severe retinyl ester deprivation...
  21. ncbi Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 12:2300-9. 2001
    ..b>Retinoids have previously been shown to significantly limit glomerular damage in rat experimental glomerulonephritis...
  22. pmc The impact of novel retinoids in combination with platinum chemotherapy on ovarian cancer stem cells
    Jenny M Whitworth
    Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, USA
    Gynecol Oncol 125:226-30. 2012
    b>Retinoids are important modulators of cell growth, differentiation, and proliferation. 9cUAB30, 9cUAB124, and 9cUAB130 are three novel retinoid compounds that show cytotoxic effects in other malignancies...
  23. ncbi Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes
    M J Roussel
    INSERM U-496, Centre G. Hayem, , avenue Claude-Vellefaux, 75010 Paris, France
    Oncogene 20:7287-91. 2001
    ..As redundancy of several names given to NB4 sublines has sometimes created difficulties, we propose a nomenclature for the various NB4 sublines that most investigators certainly would be agreed with...
  24. ncbi Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester
    A M Van Bennekum
    Department of Biochemistry, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biochemistry 38:4150-6. 1999
    ....
  25. pmc The molecular basis of retinoid absorption: a genetic dissection
    Nuttaporn Wongsiriroj
    Institute of Human Nutrition and Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 283:13510-9. 2008
    ..Contrary to what has been proposed in the literature based on in vitro studies, CRBPII does not directly prevent retinol from being acted upon by DGAT1 or other intestinal ARATs in vivo...
  26. pmc Redundant and unique roles of retinol dehydrogenases in the mouse retina
    Akiko Maeda
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Proc Natl Acad Sci U S A 104:19565-70. 2007
    ..The results suggest that RDH8 and RDH12 are dispensable in support of the visual cycle but appear to be key components in clearance of free all-trans-retinal, thereby preventing A2E accumulation and photoreceptor cell death...
  27. ncbi The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures
    Susan Reijntjes
    Institute of Medical Sciences, University of Aberdeen, Scotland, UK
    Int J Dev Biol 54:1267-75. 2010
    ..We propose that in certain regions of the embryo, there are new Rdhs and Raldhs yet to be discovered and that RA is not a major regulator of its synthetic enzymes...
  28. ncbi Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
    Alexandrine During
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lipid Res 48:2283-94. 2007
    ..In contrast to ROL transport, carotenoid uptake is mediated by the apical transporter SR-BI, and carotenoid efflux occurs exclusively via their secretion in CM...
  29. pmc Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells
    E Jaensson-Gyllenbäck
    Department of Experimental Medical Sciences, Immunology Section, Lund University, Lund, Sweden
    Mucosal Immunol 4:438-47. 2011
    ..Taken together, these results suggest a novel and unexpected role for bile in SI-LP CD103(+) DC imprinting...
  30. ncbi History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
    A Geerts
    Department of Medical Cell Biology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Semin Liver Dis 21:311-35. 2001
    ..They play a cardinal role in storage and controlled release of retinoids. They control extracellular matrix (ECM) turnover in the space of Disse by secreting the correct amounts of a ..
  31. pmc Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids
    Oriol Gallego
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Barcelona, Spain
    Biochem J 399:101-9. 2006
    ..Our results demonstrate that none of the enzymes, including the SDR members, are active with CRBPI-bound retinoids, which questions the previously suggested role of CRBPI as a retinol supplier in the retinoic acid synthesis ..
  32. ncbi Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels
    F Xavier Ruiz
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Chem Biol Interact 178:171-7. 2009
    ..reductases (AKRs) have been added to the group of enzymes which contribute to oxidoreductive conversions of retinoids. Recently, we found that two members from the AKR1B subfamily (AKR1B1 and AKRB10) were active in the reduction ..
  33. ncbi DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation
    Mariko Shutoh
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan
    Cancer 104:1609-19. 2005
    ..In this study, the authors investigated the methylation status of these genes and analyzed the role of their DNA methylation in GC...
  34. ncbi Retinoids in biological control and cancer
    Anthonise Louis Fields
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 102:886-98. 2007
    ..and physiological effects of the biologically-active natural and synthetic derivatives of vitamin A, known as retinoids. Collectively, this body of research supports the concept of retinoids as chemopreventive and chemotherapeutic ..
  35. ncbi An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation
    Masataka Kagawa
    Pharmaceutical Research Laboratories, Nikken Chemicals Co Ltd, 1 346 Kitabukuro cho, Omiya ku, Saitama shi, Saitama 330 0835, Japan
    Carcinogenesis 25:979-85. 2004
    ..01). Our results suggest that NIK-333 inhibits DEN-induced hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation...
  36. ncbi A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture
    J R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 40:2988-95. 1999
    ..To study A2E, a component of retinal pigmented epithelial (RPE) cell lipofuscin, after its internalization by cultured human RPE cells...
  37. ncbi Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells
    Josué Kunjom Mfopou
    Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel, Brussels, Belgium
    Gastroenterology 138:2233-45, 2245.e1-14. 2010
    ..We investigated whether definitive endoderm derived from human embryonic stem (hES) cells might be used to create beta cells...
  38. ncbi Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique INSERM, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Annu Rev Pharmacol Toxicol 46:451-80. 2006
    ..c) the physiological role of RA and its receptors cannot be extrapolated from teratogenesis studies using retinoids in excess...
  39. pmc The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors
    Minghao Jin
    Department of Ophthalmology, Neuroscience Center, Louisiana State University School of Medicine, New Orleans, Louisiana 70112, USA
    J Neurosci 29:1486-95. 2009
    ..IRBP is known to bind visual retinoids. Previous studies on irbp(-/-) mice suggested that IRBP plays an insignificant role in opsin-pigment ..
  40. pmc Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxi
    Olga V Belyaeva
    Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, 35294, USA
    Biochemistry 44:7035-47. 2005
    ..approximately 2000-fold lower K(m) values for NADP(+) and NADPH than for NAD(+) and NADH and recognizes both retinoids and lipid peroxidation products (C(9) aldehydes) as substrates...
  41. ncbi Retinoids in cancer chemoprevention
    Masataka Okuno
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Curr Cancer Drug Targets 4:285-98. 2004
    ..b>Retinoids are prime candidates for cancer chemoprevention since cancer is characterized by abnormal growth with a lack of ..
  42. ncbi Retinoids and vertebrate development
    L J Gudas
    Department of Pharmacology, Cornell University Medical College, New York, New York 10021
    J Biol Chem 269:15399-402. 1994
    ..we need to develop an understanding of the metabolic enzymes that control the levels of the important endogenous retinoids, including RA, in the developing embryo...
  43. ncbi CREBBP re-arrangements affect protein function and lead to aberrant neuronal differentiation
    Neeti Sharma
    National Centre for Cell Science, NCCS Complex, Pune University Complex, Ganeshkhind, Pune 411 007, India
    Differentiation 79:218-31. 2010
    ..Thus, differentiation defects are manifested early at the genomic level leading to aberrant transcription of the genes involved in differentiation along the neuronal lineage...
  44. pmc Retinoids induce stem cell differentiation via epigenetic changes
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA Electronic address
    Semin Cell Dev Biol 24:701-5. 2013
    Vitamin A (all-trans retinol) and its active metabolites, collectively called retinoids, exert potent effects on stem cell differentiation and thus, the formation of the entire organism, in part via the modulation of the epigenome...
  45. ncbi Activation of c-Raf kinase by ultraviolet light. Regulation by retinoids
    Beatrice Hoyos
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    J Biol Chem 277:23949-57. 2002
    The present study highlights retinoids as modulators of c-Raf kinase activation by UV light...
  46. pmc Mass spectrometry provides accurate and sensitive quantitation of A2E
    Danielle B Gutierrez
    Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, USA
    Photochem Photobiol Sci 9:1513-9. 2010
    ..A2E and its oxidized metabolites with greater accuracy than traditional methods, thereby facilitating a more exact analysis of bis-retinoids in animal models of inherited retinal degeneration as well as in normal and diseased human eyes.
  47. ncbi Chemoprevention of nonmelanoma skin cancer with systemic retinoids: practical dosing and management of adverse effects
    Clark C Otley
    Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Dermatol Surg 32:562-8. 2006
    ..nonmelanoma skin cancer that is high risk or characterized by numerous tumors, chemoprevention with systemic retinoids may effectively decrease the number of new tumors whereas the chemosuppressive effects may reduce the risk of ..
  48. ncbi Cosmeceuticals: focus on topical retinoids in photoaging
    Riccarda Serri
    Department of Dermatology, University of Milan, Milan, Italy
    Clin Dermatol 26:633-5. 2008
    ..appearance of photoaged skin, the only medical therapy with proven benefits in photoaged skin are topical retinoids, in particular tretinoin, isotretinoin, and tazarotene...
  49. pmc Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina
    Akiko Maeda
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    Invest Ophthalmol Vis Sci 50:5435-43. 2009
    ..The protective roles were examined of the all-trans-RDHs, Rdh8 and Rdh12, and the ATP-binding cassette transporter Abca4, retinoid cycle enzymes involved in all-trans-retinal clearance...
  50. ncbi Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 43:1222-7. 2002
    ..The purpose of this study was to evaluate the role of oxidative mechanisms in mediating the cellular damage...
  51. pmc An LC/MS method for d8-β-carotene and d4-retinyl esters: β-carotene absorption and its conversion to vitamin A in humans
    Matthew K Fleshman
    Department of Human Nutrition, The Ohio State University, Columbus, OH, USA
    J Lipid Res 53:820-7. 2012
    ..Both retinoids and β-carotene were recovered in a single simple extraction that did not involve saponification, thus allowing ..
  52. ncbi Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines
    William F Holmes
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 199:317-29. 2004
    ..b>Retinoids have great potential in the areas of cancer therapy and chemoprevention...
  53. ncbi Regulation of gene expression by retinoids
    P M Amann
    Skin Cancer Unit, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Curr Med Chem 18:1405-12. 2011
    Vitamin A serves as substrate for the biosynthesis of several derivates (retinoids) which are important for cell growth and cell differentiation as well as for vision...
  54. ncbi Decreased retinoid concentration and retinoid signalling pathways in human atopic dermatitis
    Johanna Mihály
    Laboratory of Nutritional Bioactivation and Bioanalysis, Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    Exp Dermatol 20:326-30. 2011
    ..epidermal differentiation and hyperproliferation as well as permeability dysfunction are also regulated by retinoids. The aim of our study is to identify the retinoid signalling pathways and retinoid concentration profiles in AD ..
  55. ncbi Systemic therapies for psoriasis: methotrexate, retinoids, and cyclosporine
    Richard B Warren
    Dermatologic Sciences, Hope Hospital, The University of Manchester, Manchester, M6 8HD UK
    Clin Dermatol 26:438-47. 2008
    ..Long-term maintenance therapy with retinoids and methotrexate is cost-effective and, for many patients with psoriasis, life changing...
  56. ncbi Instrumental evaluation of retinoid-induced skin irritation
    M Stucker
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    Skin Res Technol 8:133-40. 2002
    b>Retinoids like tazarotene are approved for the treatment of chronic plaque psoriasis. In the beginning of topical retinoid therapy, 15-20% of the patients suffer from mild to moderate adverse reactions with burning and erythema...
  57. ncbi Retinoids inhibit squamous cell carcinoma growth and intercellular communication
    George H Rudkin
    Plastic Surgery Section, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Surg Res 103:183-9. 2002
    b>Retinoids have been shown to inhibit the growth of squamous cell carcinoma and other malignancies...
  58. ncbi Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models
    Ruth Heise
    Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Aachen, Germany
    J Invest Dermatol 126:2473-80. 2006
    ..In light of our prior studies documenting the functional activity of RA metabolites, expression of CYP26 in the sebaceous gland epithelium supports the suggestion that altered RA metabolism may be involved in the pathogenesis of acne...
  59. ncbi Quantitative high-throughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry
    Thomas E Gundersen
    Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Rapid Commun Mass Spectrom 21:1176-86. 2007
    ..The mean extraction recoveries from spiked plasma samples were 80-105% for the various retinoids at three different levels...
  60. ncbi Carotenoids and Alzheimer's disease: an insight into therapeutic role of retinoids in animal models
    M Obulesu
    Department of Biotechnology, Rayalaseema University, Kurnool, Andhra Pradesh, India
    Neurochem Int 59:535-41. 2011
    ..The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied...
  61. ncbi Retinoid X receptor α and retinoids are key regulators in apoptosis of trophoblasts of patients with recurrent miscarriages
    A Pestka
    Department of Obstetrics and Gynaecology Innenstadt, Ludwig Maximilians University Munich, Maistrasse 11, 80337 Munich, Germany
    J Mol Endocrinol 47:145-56. 2011
    ..a reduced expression of RXRα in choriocarcinoma cell lines and in human VTs after stimulation with the retinoids 9-cis-retinoic acid and all-trans-retinoic acid and the prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J(2)...
  62. ncbi Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France
    Nat Genet 31:84-8. 2002
    ..We provide genetic evidence that ALDH1A2 and CYP26A1 activities concurrently establish local embryonic retinoic acid levels that must be finely tuned to allow posterior organ development and to prevent spina bifida...
  63. ncbi Hematopoiesis and retinoids: development and disease
    Tal Oren
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 501, Bronx, NY 10461, USA
    Leuk Lymphoma 44:1881-91. 2003
    b>Retinoids function as activating ligands for a class of nuclear receptors that control gene expression programs for a wide range of tissues and organs during embryogenesis and throughout life...
  64. ncbi Modulation of cytokine production by low and high retinoid diets in ovalbumin-sensitized mice
    Ralph Ruhl
    Institute of Nutritional Science, University of Potsdam, Potsdam Rehbrucke, Germany
    Int J Vitam Nutr Res 74:279-84. 2004
    b>Retinoids modulate many physiological processes such as the differentiation and growth of different cell types, including cells from the immune system. We have previously shown that retinoids modulate IgE production in vitro and in vivo...
  65. ncbi Are retinoids potential therapeutic agents in disorders of social cognition including autism?
    Richard P Ebstein
    Department of Psychology, Faculty of Arts and Sciences, National University of Singapore, Singapore
    FEBS Lett 585:1529-36. 2011
    ..can rescue low CD38 expressing LBC lines derived from ASD subjects and restore normal levels of transcription of this ectoenzyme providing 'proof of principle' in a peripheral model that retinoids are potential therapeutic agents in ASD.
  66. pmc Complement activation by bisretinoid constituents of RPE lipofuscin
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 50:1392-9. 2009
    ..Questions pertain to the trigger(s) responsible for the complement-associated events. The authors previously reported that photooxidation products of A2E can activate complement. Here they have further explored these events...
  67. ncbi Effects of dietary retinoids and carotenoids on immune development
    Ralph Ruhl
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Proc Nutr Soc 66:458-69. 2007
    Carotenoids and retinoids are groups of nutritionally-relevant compounds present in many foods of plant origin (carotenoids) and animal origin (mainly retinoids)...
  68. pmc Spatial localization of A2E in the retinal pigment epithelium
    Angus C Grey
    Department of Optometry and Vision Science, University of Auckland, Auckland, New Zealand
    Invest Ophthalmol Vis Sci 52:3926-33. 2011
    ..The best-characterized components of lipofuscin are A2E and its oxides, but a direct spatial correlation with lipofuscin has not previously been possible...
  69. ncbi Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways
    Edoardo Parrella
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milano 20157, Italy
    J Biol Chem 279:42026-40. 2004
    ..Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit...
  70. ncbi Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes
    Yan Zhang
    Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA
    Mol Cell Biochem 355:1-8. 2011
    ..of retinol and retinal as the active molecules, the present study was aimed to determine the effects of retinoids on insulin-mediated suppression of Pck1 expression in primary rat hepatocytes...
  71. ncbi The neurobehavioral teratology of retinoids: a 50-year history
    Jane Adams
    Department of Psychology, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
    Birth Defects Res A Clin Mol Teratol 88:895-905. 2010
    This review of the central nervous system (CNS) and behavioral teratology of the retinoids over the last 50 years is a commemorative retrospective organized by decade to show the prominent research focus within each period and the most ..
  72. ncbi Increased neonatal mortality in mice lacking cellular retinol-binding protein II
    Xueping E
    Department of Medicine, Washington University, St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:36617-23. 2002
    ..These studies suggest that both fetal as well as maternal CRBP II are required to ensure adequate delivery of vitamin A to the developing fetus when dietary vitamin A is limiting...
  73. pmc Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats
    Renata A M Luvizotto
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1808-14. 2010
    ..This process may be due to alcohol-induced PPARγ expression and lower vitamin A status in the liver...
  74. ncbi Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia Univ, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 286:E844-51. 2004
    b>Retinoids are required for normal embryonic development. Both embryonic retinoid deficiency and excess result in congenital malformations...
  75. ncbi Potential anti-inflammatory effects of topical retinoids and retinoid analogues
    John E Wolf
    Department of Dermatology, Baylor College of Medicine Houston, Texas 77030 3411, USA
    Adv Ther 19:109-18. 2002
    ..These multiple mechanisms of action should encourage clinicians to consider these agents in the first-line management of inflammatory acne lesions...
  76. ncbi Retinoids: pleiotropic agents of therapy for vascular diseases?
    Jeffrey W Streb
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Drug Targets Cardiovasc Haematol Disord 3:31-57. 2003
    b>Retinoids, the natural and synthetic derivatives of vitamin A, exert broad biological effects and have been used clinically to treat a variety of dermatological and neoplastic diseases...
  77. ncbi Detection of endogenous retinoids in the molluscan CNS and characterization of the trophic and tropic actions of 9-cis retinoic acid on isolated neurons
    Jennifer M Dmetrichuk
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada L2S 3A1
    J Neurosci 28:13014-24. 2008
    ....
  78. ncbi All-trans-retinyl esters are the substrates for isomerization in the vertebrate visual cycle
    Deviprasad R Gollapalli
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 45 Shattuck Street, Boston, Massachusetts 02115, USA
    Biochemistry 42:5809-18. 2003
    ..The converse is true with vitamin A. These data unambiguously establish all-trans-retinyl esters as the precursors of 11-cis-retinol...
  79. ncbi Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action
    Rui Li
    Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA
    Biochem Biophys Res Commun 406:268-72. 2011
    ..We conclude that retinoids regulate hepatic Srebp-1c expression through activation of retinoid X receptor...
  80. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011
    ..Thus, a defect in the endogenous synthesis of retinoic acid contributes to loss of the protection by retinoic acid in HIVAN. Hence, RARα agonists may be potential agents for the treatment of HIVAN...
  81. pmc Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice
    Sheila M O'Byrne
    Institute of Human Nutrition, Columbia University, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 298:E862-70. 2010
    b>Retinoids are absolutely required for normal growth and development during the postnatal period. We studied the delivery of retinoids to milk, availing of mouse models modified for proteins thought to be essential for this process...
  82. pmc Identification of a novel retinoid by small molecule screening with zebrafish embryos
    Chetana Sachidanandan
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 3:e1947. 2008
    ....
  83. pmc Retinoids synergize with insulin to induce hepatic Gck expression
    Guoxun Chen
    Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, U S A
    Biochem J 419:645-53. 2009
    ..b>Retinoids synergized with insulin to induce Gck expression by the activation of both RAR [RA (retinoic acid) receptor] and ..
  84. pmc Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: a potential mechanism of ethanol toxicity
    MAUREEN A KANE
    119 Morgan Hall, MC 3104, University of California, Berkeley, Berkeley, CA 94720 3104, USA
    FASEB J 24:823-32. 2010
    ..Kane, M. A., Folias, A. E., Wang, C., Napoli, J. L. Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: a potential mechanism of ethanol toxicity...
  85. pmc The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
    Johannes von Lintig
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Trends Biochem Sci 35:400-10. 2010
    Recently, much progress has been made in elucidating the chemistry and metabolism of retinoids and carotenoids, as well as the structures of processing proteins related to vision...
  86. ncbi Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids
    X Feng
    Department of Dermatology, University of Michigan, Ann Arbor 48109 0314, USA
    Genes Dev 11:59-71. 1997
    ..Accordingly, we suggest that in vivo: (1) in suprabasal keratinocytes, retinoids regulate gene transcription via RAR-RXR heterodimers in which RAR confers a predominant ligand response, whereas ..
  87. ncbi Retinoids in nephrology: promises and pitfalls
    Qihe Xu
    Department of Medicine, Royal Free and University College Medical School, University College London, London, UK
    Kidney Int 66:2119-31. 2004
    b>Retinoids, a family of vitamin A metabolites or analogs, play an important role in regulating cell proliferation, differentiation, and apoptosis.
  88. ncbi Oxidative conversion of carotenoids to retinoids and other products
    Akihiko Nagao
    National Food Research Institute, Tsukuba, Ibaraki 305 8642, Japan
    J Nutr 134:237S-240S. 2004
    ..Thus, it is worth evaluating the formation of oxidation products and their biological actions, in order to elucidate the underlying mechanisms of the beneficial effects of carotenoids on human health...
  89. pmc Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner
    Glenn P Lobo
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:27891-9. 2010
    ..Two different precursors for retinoids exist in the diet as preformed vitamin A (all-trans-retinol) and provitamin A (beta,beta-carotene)...
  90. ncbi Retinoids as chemoprevention for head and neck cancer: where do we go from here?
    Wade Smith
    Winship Cancer Institute, Hematology Oncology, Emory University, 1365 Clifton Road, Bldg C, Room 3094, Atlanta, GA 30322, USA
    Crit Rev Oncol Hematol 55:143-52. 2005
    The retinoids, natural and synthetic derivatives of vitamin A, have a promising role in the chemoprevention of head and neck squamous cell carcinoma despite facing the limitations of toxicity as well as innate and acquired resistance...
  91. pmc Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis
    Rebeca Acín-Pérez
    Department of Neurology and Neurobiology Weill Cornell Medical School, New York, New York, USA
    FASEB J 24:627-36. 2010
    ..soon as retinol was restored to physiological concentration, without the need for metabolic conversion to other retinoids. Retinol emerged as an essential cofactor of protein kinase Cdelta (PKCdelta), without which this enzyme failed ..
  92. pmc Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1
    Xin M Luo
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:36228-36. 2005
    ..Experiments using receptor-selective retinoids revealed that ligands for retinoic acid receptor-alpha (RARalpha), including atRA, 9-cis-retinoic acid, and ..
  93. pmc Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
    Michelle Y S Shih
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    J Biol Chem 284:4292-9. 2009
    ..Our findings may have implications for human skin or hair disorders treated with agents that modulate RA signaling...
  94. ncbi Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Endocrinology 146:4479-90. 2005
    Circulating retinoids (vitamin A and its derivatives) are found predominantly as retinol bound to retinol-binding protein (RBP), which transports retinol from liver stores to target tissues, or as retinyl ester incorporated in ..
  95. pmc Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation
    Cynthia K Hahn
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9751-6. 2008
    ....
  96. ncbi Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin
    Shimon Ben-Shabat
    Department of Chemistry, Columbia University, New York, NY 10028, USA
    J Biol Chem 277:7183-90. 2002
    ..The identities of additional minor components of retinal pigment epithelium lipofuscin, A2E isomers with cis olefins at positions other than the C13-C14 double bond, are also described...
  97. ncbi A novel role for retinoids in patterning the avian forebrain during presomite stages
    Aida Halilagic
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 130:2039-50. 2003
    b>Retinoids, and in particular retinoic acid (RA), are known to induce posterior fates in neural tissue. However, alterations in retinoid signalling dramatically affect anterior development...
  98. pmc Phospholipid meets all-trans-retinal: the making of RPE bisretinoids
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    J Lipid Res 51:247-61. 2010
    ..The propensity of these compounds to negatively impact on the cells has been linked to the pathogenesis of some retinal disorders including juvenile onset recessive Stargardt disease and age-related macular degeneration...
  99. pmc Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness
    J P Van Hooser
    Departments of Ophthalmology, Chemistry, and Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:8623-8. 2000
    ....
  100. ncbi Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells
    Nathan L Mata
    Jules Stein Eye Institute, University of California School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 279:635-43. 2004
    ..Rpe65-/- knockout mice massively accumulate all-trans-retinyl esters but lack 11-cis-retinoids and rhodopsin visual pigment in their retinas...
  101. ncbi Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1
    Dharamainder Choudhary
    Department of Pharmacology, MC1505, 263 Farmington Avenue, Farmington, CT 06030, USA
    Drug Metab Dispos 32:840-7. 2004
    ..However, CYP1 enzymes are also capable of metabolism of endobiotics, and in the present study, the metabolism of retinoids and lipid endobiotics by human CYP1B1 and mouse Cyp1b1 orthologs was compared...

Research Grants68

  1. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Therefore, deficiencies in dietary antioxidants such as retinoids and carotenoids, which previously have been reported in CLD, may constitute a major modifiable risk factor...
  2. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..The molecular events that underlie alcohol-associated disease are complex and not completely understood. Retinoids (vitamin A and its metabolites) are potent transcriptional regulators that are needed for mediating normal cell ..
  3. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..toxicity of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  4. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ..The biological effects of retinoids are typically mediated via interaction with their cognate nuclear receptors, namely, retinoic acid receptors (..
  5. ANALYSIS OF NEMATODE SEX DETERMINATION
    Barbara J Meyer; Fiscal Year: 2013
    ..Disruptions in RARs are associated with human cancers, knowledge that has lead to the use of retinoids in the treatment of leukemias. Information gained from model organisms such as C...
  6. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2013
    ..toxicity of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  7. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2013
    ..We will also test the RXR selective retinoids bexarotene (LG1069) and LG100268, which have achieved positive results in other cancer chemoprevention models...
  8. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
    ..Since retinoids cannot be synthesized de novo by humans, dietary precursors must be absorbed by the intestine and metabolically ..
  9. HORMONES: BIOCHEMISTRY AND MOLECULAR BIOLOGY
    MAX ELLIOT GOTTESMAN; Fiscal Year: 2013
    ..Training faculty are actively engaged in research programs: including neuroendocrine-immune interactions;role of retinoids in breast and cervical cancers, in urogenital tract development, and in diabetes;genetics of obesity and non-..
  10. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
    ..Our laboratory has studied the mechanisms by which retinoids (vitamin A (retinol) and its derivatives and metabolites), control gene expression in both normal stem cells and ..
  11. MEMBRANE BASIS OF VISUAL EXCITATION
    Michael F Brown; Fiscal Year: 2012
    ..the rhodopsin binding cavity that stabilize the activated Meta II state will be investigated with modified retinoids that dramatically shift the Meta I Meta II equilibrium...
  12. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    ..A is an essential nutrient for the developing embryo, which depends on maternal circulating vitamin A (or retinoids) to fulfill its needs...
  13. Retinoic Acid, Its Receptors, and the Liver
    Yu Jui Yvonne Wan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinoids have broad effects including development, growth, cell death, and anti-oxidation. Their actions have been extensively studied in the skin, eye, and in many types of cancer...
  14. Inhibition in the progression of preinvasive lung cancer by pomegranate.
    Naghma Khan; Fiscal Year: 2012
    ..b>Retinoids are required for proper differentiation of lung and upper airway epithelium, and loss of expression of retinoic ..
  15. Mechanisms of Antifibrotic Actions of Relaxin in the Liver
    Robert G Bennett; Fiscal Year: 2013
    ..Normally, HSC display a quiescent phenotype, and function to store lipids in the form of retinoids. With liver injury, HSC lose their retinoid stores and adopt an activated phenotype, characterized by increased ..
  16. Stimulated by Retinoic Acid (STra6) in Energy Homeostasis
    LAURA H ZEMANY; Fiscal Year: 2013
    ..Since STRA6 mediates the cellular uptake of retinol, serum and tissue levels of retinoids such as retinol and retinoic acid will be determined...
  17. Retinoids and Hyperoxic Lung Injury
    Masheika L James; Fiscal Year: 2012
    ..newborn mice have decreased lung VA stores and impaired lung development and function, which are attenuated by retinoids. Our laboratory has made the novel observations that Thy-1 null mice have IAD and increased TGF-Beta activation ..
  18. Molecular Regulation of LRAT and CYP26 in Lung and Liver
    A Catharine Ross; Fiscal Year: 2012
    ..tissues as retinyl esters (RE), which, through hydrolysis and controlled oxidative metabolism generate bioactive retinoids, including retinoic acid (RA). Retinoic acid is a critical regulator of cell differentiation...
  19. INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    MARTIN FREDERICK KAGNOFF; Fiscal Year: 2013
    ..Research Unit 4, which is new to the Program with the renewal application, investigates mechanisms by which retinoids determine the balance between normal mucosal homeostasis and protective immunity through their activity on DC ..
  20. Biophysical Studies on Nuclear Receptor LBDs
    Elias J Fernandez; Fiscal Year: 2012
    ..Hormonal molecules such as glucocorticoids, retinoids, thyroid and vitamin-derived hormones exert their effects by regulating the transcription of hormone-responsive ..
  21. Molecular Events in Urinary Tract Formation
    CATHY LEE MENDELSOHN; Fiscal Year: 2012
    ..Using mouse models, we have shown that ureter insertion depends on retinoic acid and that retinoids act by inducing transcription of Ret, a gene required for kidney development and for ureter insertion...
  22. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2013
    ..These data could also help improve the way retinoids are used to prevent and treat certain types of cancer...
  23. Endometriosis and Retinoids
    Serdar E Bulun; Fiscal Year: 2013
    ....
  24. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..A novel therapeutic modality will be developed: pretreatment of cancer cells with macromolecular retinoids will lead to differentiation of cancer cells resulting in enhanced susceptibility to chemotherapy and/or ..
  25. Function of 9-cis-retinoic acid
    Joseph L Napoli; Fiscal Year: 2013
    ..These data validate 9cRA as a naturally occurring retinoid with physiological function(s) unique among retinoids, and identify a novel component of 2-cells that contributes to insulin secretion...
  26. Genetic Rescue of Retinoid-Induced Dysfunction
    Pilar Ruiz-Lozano; Fiscal Year: 2013
    ..mouse models in which myocyte intracellular retinoid signaling is obliterated, and have demonstrated that retinoids play a pivotal role in maintaining cardiac function during adulthood...
  27. Alcohol Consumption and Brown Adipose Tissue
    William S Blaner; Fiscal Year: 2013
    ..This hypothesis has its origins in the established effects that retinoids have on BAT differentiation and function, as well as our preliminary data which indicates that BAT of alcohol-..
  28. The Role of Liver X Receptors (LXRs) in the Pathogenesis of Hepatic Fibrosis
    SIMON WILLIAM BEAVEN; Fiscal Year: 2013
    ..These cells store 80% of the body's supply of retinoids (Vitamin A and its metabolites) but the function of retinoids in stellate cells is largely unknown...
  29. UAB Rexinoids for Breast Cancer Prevention
    Donald D Muccio; Fiscal Year: 2011
    ..At UAB, we designed and synthesized two new classes of RXR- selective retinoids, named UAB rexinoids...
  30. Development of an HTS assay to identify FXR antagonists
    Thomas P Burris; Fiscal Year: 2010
    ..of the human nuclear hormone receptor (NR) superfamily serve as receptors for steroids, thyroid hormones, retinoids, oxysterols, fatty acids, and bile acids...
  31. Genetics and Therapy of Age-related Retinal Dysfunction in A/J Mice
    Tadao Maeda; Fiscal Year: 2013
    ..2) Assess age-related retinal dysfunction in A/J mice treated with either 9-cis-retinoids or retinylamine or combination of both drugs...
  32. Psoriasis treatments, cardiovascular disease, and diabetes
    Lisa J Herrinton; Fiscal Year: 2013
    ..The drugs under study will include anti-TNF agents, methotrexate, oral retinoids and cyclosporine. Risk on these drugs will be compared to risk on phototherapy without systemic agent...
  33. Dissection of a Developmental Checkpoint That Preserves Regenerative Capacity
    ADRIAN J HALME; Fiscal Year: 2013
    ..Molecular and genetic experiments will be used to determine the role of retinoids in inhibiting a neuroendocrine positive feedback loop that regulates developmental progression...
  34. Innate Immunity in Acne Vulgaris
    Jenny J Kim; Fiscal Year: 2013
    ..In addition, given the restrictions placed on the use of oral retinoids as well as the development of antibiotic- resistant strains of P. acnes, research is needed to improve therapy...
  35. A Novel Class of Topical Pleitropic Anti-Acne Therapeutics
    Joel S Gordon; Fiscal Year: 2010
    ..Treatments, such as antibiotics and benzylperoxide (BPO) are directed at the bacterium P. acnes and retinoids target sebum control. Several antimicrobial and retinoids also possess anti-inflammatory activity...
  36. FoxP3+ T cells of mucosal tissues
    Chang H Kim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vitamin A (retinol) and its metabolites (called retinoids) play critical roles in the immune system...
  37. Novel adamantyl arotinoids for the prevention and treatment of prostate cancer
    Francisco Javier Piedrafita; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Retinoids are vitamin A derivatives that regulate gene expression through activation of the nuclear retinoid receptors (RARs and RXRs)...
  38. APC and Retinoids in Zebrafish Enterocyte Development
    David A Jones; Fiscal Year: 2013
    ..This understanding could support a testable clinical hypothesis using new combined therapies for preventing human colon cancer. ..
  39. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2012
    The overall goal of this project is to understand the mechanism of action and clinical potential of retinoids in endometriosis...
  40. Novel Skin Protectant Retinoid for the Treatment of Psoriasis
    KRYS BOJANOWSKI; Fiscal Year: 2013
    ..in lesions and hyperkeratosis, and can be partially remediated with prescription medicines, such as topical retinoids. Despite their great potential, current topical retinoid drugs are typically used at suboptimal doses, due to ..
  41. EARLY EVENTS IN MAMMALIAN B-CELL DIFFERENTIATION
    PAUL WAYNE KINCADE; Fiscal Year: 2012
    by cytokines, hormones and cell adhesion molecules. In addition, we have new observations suggesting that retinoids can accelerate the process of lymphocyte formation and their effects on the bone marrow merit further study...
  42. 2010 FASEB Conference on the Retinoids
    Noa Noy; Fiscal Year: 2010
    ..for the 15th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at the Carefree Resort in Carefree, Arizona in June 13-18, 2010...
  43. RETINOIDS IN VISION
    KRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2013
    ..Finally, we will identify the mechanisms of all-trans-retinal-induced retinal degeneration by dissecting out those signaling events that lead to the death of retinal cells. ..
  44. Regulation of synaptic transmission by retinoic acid signaling
    Lu Chen; Fiscal Year: 2013
    ..on their implications for understanding of synaptic transmission, but also on their potential relevance for retinoids-related neurological disorders such as depression and memory loses...
  45. FASEB SRC on RETINOIDS
    EARL HOWARD HARRISON; Fiscal Year: 2012
    ..for the 16th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at the Snowmass Resort in Snowmass, Colorado on June 5-12, 2012...
  46. Opoid and Retinoid Interactions in the HIV-1 Transgenic Rat
    Walter Royal; Fiscal Year: 2011
    ..These effects have been observed to be enhanced in opioid users. Retinoids have been demonstrated to suppress such immune activity, and, in studies of HIV-1 infection, can suppress ..
  47. Interphotoreceptor Retinoid Binding Protein: Structure and Function
    Federico Gonzalez-Fernandez; Fiscal Year: 2011
    ..The mechanism by which IRBP protects retinoids from isomeric and oxidative degradation while targeting their delivery/release between the above cells during ..
  48. Use of Xenopus a system to study the trafficking,function and structure of IRBP
    Federico Gonzalez-Fernandez; Fiscal Year: 2013
    ..RPE surface, and M[unreadable]ller cell villi, The mechanism for IRBP's complex function in protecting retinoids from isomeric and oxidative degradation while targeting their delivery/release between the above cells during ..
  49. Retinoids in Hematopoiesis
    John S Welch; Fiscal Year: 2011
    ..b>Retinoids regulate the opposing pathways of hematopoietic self-renewal and differentiation...
  50. Retinoic acid signaling controls urothelial development and regeneration
    CATHY LEE MENDELSOHN; Fiscal Year: 2013
    ..molecule that can induce embryonic stem cells to differentiate into urothelial cells in culture, suggesting that retinoids may normally regulate urothelial progenitors...
  51. Photosensitive control of the inner retina
    Kenneth P Greenberg; Fiscal Year: 2010
    ..These rhodopsins use retinoids as their chromophore and directly modulate activity without accessory protein cascades or exogenous chemicals...
  52. Retinoids in Hematopoiesis
    John S Welch; Fiscal Year: 2013
    ..b>Retinoids regulate the opposing pathways of hematopoietic self-renewal and differentiation...
  53. TISSUE SPECIFIC EXPRESSION AND FUNCTION OF ME-RABP
    Marie Claire Orgebin Crist; Fiscal Year: 2002
    ..The retinoids being hydrophobic labile compounds are transported in a aqueous environments bound to specific carrier proteins...
  54. Targets of Retinoid-Dependent Heart Development
    Karen A Niederreither; Fiscal Year: 2009
    ..Moreover, since retinoids are potent regulators of cell proliferation, understanding downstream signaling could open up new strategies to ..
  55. SYNTHETIC RETINAL PIGMENTS AND BINDING PROTEINS
    Rosalie K Crouch; Fiscal Year: 2011
    Our long-term goal is to define the roles of retinoids in the visual transduction process and to explore the potential of retinal analogs in treating disorders resulting from improper retinoid processing, such as in Leber's ..
  56. NUCLEAR RECEPTOR LIGAND TARGETING BY THE FATTY ACID BINDING PROTEINS: IMPLICATION
    Mary Kathryn Doud; Fiscal Year: 2013
    ..of this work is to further investigate this partitioning between RAR and PPARDELTA using naturally occurring retinoids and fatty acids as probes...
  57. THE ROLE OF RETINOIDS IN LACRIMAL GLAND FUNCTION
    John Ubels; Fiscal Year: 2002
    ..gland transports, metabolizes and secretes vitamin A which is required by the ocular surface epithelium and that retinoids (vitamin A derivatives) are required for maintenance of lacrimal gland structure and function...
  58. CHEMOPREVENTION IN HUMAN BRONCHIAL METAPLASIA/DYSPLASIA
    WAUN HONG; Fiscal Year: 1991
    Vitamin A and synthetic analogs (retinoids) can modulate the growth and differentiation of normal, premalignant, and malignant cells in-vivo and in- vitro...
  59. RETINOIDS & RECEPTORS IN BLADDER CANCER CHEMOPREVENTION
    Changping Zou; Fiscal Year: 2003
    ..Natural and synthetic retinoids have been tested as chemopreventive and chemotherapeutic agents against oral tumors, but the effects of these ..
  60. BETA-CAROTENE IN HUMAN MILK: QUANTITATION AND TRANSPORT
    Louise Canfield; Fiscal Year: 1993
    ..This project will be conducted in two phases. As detailed quantitative information about retinoids and carotenoids in human milk is lacking, our objective in Phase I is to identify the major carotenoids and ..
  61. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    ..Hypothesis: The perinatal lung contains a supply of retinoids, that it may use during the period of maximal alveolar septal elastin synthesis...
  62. RETINOID SIGNALING IN HUMAN BRONCHIAL EPITHELIAL CELL
    Jonathan Kurie; Fiscal Year: 1999
    ..Lung cancer "chemoprevention" is an exciting new strategy, and recent chemoprevention trials have revealed that retinoids are active in the prevention of lung cancer...
  63. MARKERS OF RESPONSE IN CUTANEOUS T-CELL LYMPHOMA
    Madeleine Duvic; Fiscal Year: 1999
    ..Mycosis fungoides, the most common form of CTCL, has similarities to benign skin diseases. Experimental retinoids are being developed for the therapy of CTCL, but their mechanisms of action are not fully understood...
  64. FASEB SUMMER RESEARCH CONFERENCE ON RETINOIDS
    Peter Davies; Fiscal Year: 1990
    This application requests partial support for the 1990 FASEB Summer Research Conference on Retinoids. This conference is scheduled to be held June 17-22, 1990, at the Vermont Academy in Sarton's River, VT...
  65. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 2002
    ..can be used as an in vitro model system to study the anti-proliferative and differentiation-inducing effects of retinoids. Additionally, their ability to undergo terminal differentiation into several distinct cell types upon RA ..
  66. IMMUNOLOGICAL ASPECTS OF RETINOIDS IN HUMAN CANCER
    Neil Sidell; Fiscal Year: 1993
    ..of this proposal is to continue to investigate cellular, molecular, and electrophysiologic mechanisms by which retinoids induce the differentiation and modulate the immunocompetence of human lymphocytes...
  67. EFFECTS OF RETINOIDS & GROWTH FACTORS ON BRANCHIAL ARCH
    JAN KRONMILLER; Fiscal Year: 1992
    ..The exact nature of the inductive signal is not known. Retinoids (retinoic acid and retinol) affect craniofacial development...
  68. Endogenous retinoids in mammalian skin and hair function
    HELEN EVERTS; Fiscal Year: 2009
    ..grant is to obtain and maintain a faculty position and research career in nutrition science with a focus on retinoids in skin and hair and their diseases...