normetanephrine

Summary

Summary: A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.

Top Publications

  1. ncbi [The diagnosis of atypical pheochromocytoma: a challenge for the biologist as well]
    L Peyrin
    Laboratoire de Physiologie, , avenue Rockefeller, 69373 Lyon, France
    Pathol Biol (Paris) 49:247-54. 2001
  2. ncbi Pheochromocytoma: a disease with many faces
    Marina Shargorodsky
    Isr Med Assoc J 4:817-8. 2002
  3. pmc Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine III, University of Dresden, Dresden, Germany
    Clin Chem 57:411-20. 2011
  4. ncbi Diagnostic value of various biochemical parameters for the diagnosis of pheochromocytoma in patients with adrenal mass
    Nicole Unger
    Division of Endocrinology, Medical Centre, University of Essen, Germany
    Eur J Endocrinol 154:409-17. 2006
  5. ncbi The diagnostic efficacy of urinary fractionated metanephrines measured by tandem mass spectrometry in detection of pheochromocytoma
    C G Perry
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    Clin Endocrinol (Oxf) 66:703-8. 2007
  6. ncbi Diagnostic accuracy of free and total metanephrines in plasma and fractionated metanephrines in urine of patients with pheochromocytoma
    Eric Grouzmann
    Division of Clinical Pharmacology and Toxicology, University Hospital, Lausanne, Switzerland
    Eur J Endocrinol 162:951-60. 2010
  7. ncbi Plasma and urinary metanephrines determined by an enzyme immunoassay, but not serum chromogranin A for the diagnosis of pheochromocytoma in patients with adrenal mass
    N Unger
    Department of Endocrinology and Division of Laboratory Research, Medical Center, University of Duisburg Essen, Essen, Germany
    Exp Clin Endocrinol Diabetes 120:494-500. 2012
  8. ncbi Performance of plasma fractionated free metanephrines by enzyme immunoassay in the diagnosis of pheochromocytoma and paraganglioma in children
    Vijaya Sarathi
    Department of Endocrinology, Seth GS Medical College, Mumbai, India
    Endocr Pract 18:694-9. 2012
  9. ncbi Dietary influences on plasma and urinary metanephrines: implications for diagnosis of catecholamine-producing tumors
    Wilhelmina H A de Jong
    Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Clin Endocrinol Metab 94:2841-9. 2009
  10. ncbi Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors
    Michel Procopiou
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A7BE, UK
    Eur J Endocrinol 161:131-40. 2009

Research Grants

Detail Information

Publications196 found, 100 shown here

  1. ncbi [The diagnosis of atypical pheochromocytoma: a challenge for the biologist as well]
    L Peyrin
    Laboratoire de Physiologie, , avenue Rockefeller, 69373 Lyon, France
    Pathol Biol (Paris) 49:247-54. 2001
    ..Analysis of the ratio NMN/MN in plasma provides an additional diagnosis tool to reveal adrenaline secretion abnormalities...
  2. ncbi Pheochromocytoma: a disease with many faces
    Marina Shargorodsky
    Isr Med Assoc J 4:817-8. 2002
  3. pmc Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma
    Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine III, University of Dresden, Dresden, Germany
    Clin Chem 57:411-20. 2011
    ..This study assessed whether measurements of plasma metanephrine, normetanephrine, and methoxytyramine, the O-methylated metabolites of catecholamines, might help to distinguish different ..
  4. ncbi Diagnostic value of various biochemical parameters for the diagnosis of pheochromocytoma in patients with adrenal mass
    Nicole Unger
    Division of Endocrinology, Medical Centre, University of Essen, Germany
    Eur J Endocrinol 154:409-17. 2006
    ..Pheochromocytomas are neoplasms generally characterized by the autonomous production of catecholamines. This study compared various biochemical parameters for the diagnosis of adrenal pheochromocytoma in patients with adrenal mass...
  5. ncbi The diagnostic efficacy of urinary fractionated metanephrines measured by tandem mass spectrometry in detection of pheochromocytoma
    C G Perry
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    Clin Endocrinol (Oxf) 66:703-8. 2007
    ..We also developed clinically based cut-offs for positivity of this measurement...
  6. ncbi Diagnostic accuracy of free and total metanephrines in plasma and fractionated metanephrines in urine of patients with pheochromocytoma
    Eric Grouzmann
    Division of Clinical Pharmacology and Toxicology, University Hospital, Lausanne, Switzerland
    Eur J Endocrinol 162:951-60. 2010
    ..Plasma free and urinary metanephrines are recognized biomarkers for the assessment of pheochromocytoma. Plasma total metanephrines with a long half-life may represent another useful biomarker...
  7. ncbi Plasma and urinary metanephrines determined by an enzyme immunoassay, but not serum chromogranin A for the diagnosis of pheochromocytoma in patients with adrenal mass
    N Unger
    Department of Endocrinology and Division of Laboratory Research, Medical Center, University of Duisburg Essen, Essen, Germany
    Exp Clin Endocrinol Diabetes 120:494-500. 2012
    ..Plasma and urinary metanephrine and normetanephrine as well as chromogranin A were determined and putative thresholds were calculated by ROC analysis...
  8. ncbi Performance of plasma fractionated free metanephrines by enzyme immunoassay in the diagnosis of pheochromocytoma and paraganglioma in children
    Vijaya Sarathi
    Department of Endocrinology, Seth GS Medical College, Mumbai, India
    Endocr Pract 18:694-9. 2012
    ..To establish pediatric reference ranges for plasma fractionated free metanephrines by enzyme immunoassay (EIA) and to evaluate its performance in the diagnosis of catecholamine-secreting tumors in the pediatric population...
  9. ncbi Dietary influences on plasma and urinary metanephrines: implications for diagnosis of catecholamine-producing tumors
    Wilhelmina H A de Jong
    Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Clin Endocrinol Metab 94:2841-9. 2009
    ..Measurements of the 3-O-methylated metabolites of catecholamines [metanephrines (MNs)] in plasma or urine are recommended for diagnosis of pheochromocytoma. It is unclear whether these tests are susceptible to dietary influences...
  10. ncbi Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors
    Michel Procopiou
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A7BE, UK
    Eur J Endocrinol 161:131-40. 2009
    To define the test characteristics of an enzyme immunoassay (EIA) for plasma-free metanephrines (metanephrine and normetanephrine) in the diagnosis of pheochromocytoma and paraganglioma.
  11. ncbi Evaluation of specific high-performance liquid-chromatographic determinations of urinary metanephrine and normetanephrine by comparison with isotope dilution mass spectrometry
    J J Willemsen
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, The Netherlands
    Ann Clin Biochem 38:722-30. 2001
    A method for the determination of metanephrine (MN; also known as metadrenaline), normetanephrine (NMN; also known as normetadrenaline) and 3-methoxytyramine (3-MT) in human urine using high-performance liquid chromatography followed by ..
  12. ncbi Toward a rapidly acting antidepressant: the normetanephrine and extraneuronal monoamine transporter (uptake 2) hypothesis
    Joseph J Schildkraut
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Chestnut Hill, MA 02467, USA
    Am J Psychiatry 161:909-11. 2004
    ..The authors considered the possible role of the extraneuronal monoamine transporter (uptake 2) in accounting for the delay in clinical action of norepinephrine reuptake inhibitor antidepressant drugs...
  13. ncbi Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2
    G Eisenhofer
    Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    N Engl J Med 340:1872-9. 1999
    ..In this study we evaluated measurements of plasma normetanephrine and metanephrine for detecting pheochromocytomas in patients with von Hippel-Lindau disease or MEN-2.
  14. ncbi Measurement of plasma free metanephrine and normetanephrine by liquid chromatography-tandem mass spectrometry for diagnosis of pheochromocytoma
    Susan A Lagerstedt
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Clin Chem 50:603-11. 2004
    ..The aim of this study was to develop a sensitive and specific LC-MS/MS method for plasma free metanephrines...
  15. ncbi Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma
    Robert L Taylor
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Chem 48:533-9. 2002
    ..g., paragangliomas and neuroblastomas). We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the measurement of urinary conjugated metanephrines...
  16. ncbi Implication of the signal transduction pathways in the enhancement of noradrenaline turnover induced by morphine withdrawal in the heart
    M Delia Martínez
    Equip of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain
    Eur J Pharmacol 471:113-9. 2003
    ..concomitantly with morphine significantly antagonized the increase in normetanephrine/noradrenaline ratio (an index of noradrenaline turnover) observed in morphine withdrawn rats...
  17. ncbi An apparent phaeochromocytoma and abnormal thyroid function tests
    T F J King
    Department of Endocrinology, Beaumont Hospital, Dublin 9, Ireland
    Ann Clin Biochem 45:215-7. 2008
    ..Urinary fractionated metanephrine and normetanephrine concentrations were within the normal reference range...
  18. ncbi Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension
    D S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Neurology 60:1327-32. 2003
    ..From the concept of a unitary sympathoadrenomedullary system, one might predict parallel sympathoneural and adrenomedullary abnormalities in NOH...
  19. ncbi Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:735-44. 2005
    Measurements of plasma free metanephrines (normetanephrine and metanephrine) provide a useful test for diagnosis of pheochromocytoma and may provide other information about the nature of these tumors.
  20. ncbi Sources and significance of plasma levels of catechols and their metabolites in humans
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620
    J Pharmacol Exp Ther 305:800-11. 2003
    ..of catechols include 3-methoxytyrosine (from L-DOPA), homovanillic acid and dopamine sulfate (from dopamine), normetanephrine, vanillylmandelic acid, and methoxyhydroxyphenylglycol (from norepinephrine), and metanephrine (from ..
  21. ncbi Psychobiologic responses to 4 days of increased training and recovery in cyclists
    E Filaire
    CRIS, UFRSTAPS, Universite Claude Bernard Lyon I, Villeurbanne, France
    Int J Sports Med 23:588-94. 2002
    ..For this purpose, urinary excretion of methoxyamines (metanephrine [MN], normetanephrine [NMN]), which are metabolites of circulating catecholamines, 3-methoxy-4-hydroxyphenyl glycol sulfate (MHPG-S)..
  22. ncbi Liquid chromatography method for detecting native fluorescent bioamines in urine using post-column derivatization and intramolecular FRET detection
    Makoto Yoshitake
    Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma, Johnan, Fukuoka 814 0180, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 858:307-12. 2007
    ..This method provides sufficient selectivity and sensitivity for the determination of normetanephrine, dopamine, tyrosine, 5-hydroxytryptamine, tryptamine, and tryptophan in healthy human urine without prior ..
  23. ncbi [Difficult diagnosis of a pancreatic paraganglioma]
    G Perrot
    Service des Maladies de l Appareil digestif, HIA Desgenettes, 108 boulevard Pinel, 69275 Lyon cedex 03, France
    Rev Med Interne 28:701-4. 2007
    ..Invasive investigations with puncture or primary surgical resection must be avoided because of the risk of vital complications...
  24. ncbi Parkinson's disease: the effect of L-dopa therapy on urinary free catecholamines and metabolites
    D F Davidson
    Department of Biochemistry, Crosshouse Hospital, Glasgow, UK
    Ann Clin Biochem 44:364-8. 2007
    ..This is the first assessment of the effect of exogenous administration of L-dopa on urinary free metadrenalines...
  25. ncbi [Metanephrine (M), normetanephrine (NM) and fractionated metanephrines]
    Taku Miyoshi
    Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University
    Nihon Rinsho 63:395-8. 2005
  26. ncbi Pheochromocytoma presenting as heart failure
    Jennifer A Farroni
    Ohio State University, Ross Heart Hospital, Columbus, OH 43210, USA
    Prog Cardiovasc Nurs 20:117-9. 2005
    ..The authors describe the case of a young man who presented to the hospital with acute heart failure who was later diagnosed with a pheochromocytoma...
  27. ncbi Cortisol production rate in posttraumatic stress disorder
    G H Trevor Wheler
    Department of Psychiatry, UHN 80, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239 3098, USA
    J Clin Endocrinol Metab 91:3486-9. 2006
    ..Several authors have reported the unsuspected finding of low cortisol levels (urinary, salivary, and serum) in patients with posttraumatic stress disorder (PTSD)...
  28. ncbi Decomposition of protonated noradrenaline and normetanephrine assisted by NH2 migration studied by electrospray tandem mass spectrometry and molecular orbital calculations
    Françoise Rogalewicz
    Laboratoire des Mecanismes Reactionnels, Unité Mixte de recherche CNRS 7651, Ecole Polytechnique, 91128 Palaiseau Cedex, France
    Rapid Commun Mass Spectrom 19:743-51. 2005
    ..The decompositions of protonated noradrenaline (VH) and normetanephrine (VIH) were studied...
  29. ncbi Utility of plasma free metanephrines in diagnosis of factitious pheochromocytoma
    Aaron R Chidakel
    Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Diseases, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Pract 12:568-71. 2006
    ..To report a case of epinephrine-induced factitious pheochromocytoma in a young woman with a past medical history of Conn's syndrome...
  30. ncbi Malignant pheochromocytoma associated with germline mutation of the SDHB gene
    Zishan Allibhai
    Division of Radiation Oncology, London Regional Cancer Centre and University of Western Ontario, London, Ontario, Canada
    J Urol 172:1409-10. 2004
  31. ncbi Catecholamines, infection, and death in acute ischemic stroke
    Angel Chamorro
    Stroke Unit, Hospital Clinic and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    J Neurol Sci 252:29-35. 2007
    ..non-septic stroke was compared in this prospective study with longitudinal changes of cytokines, leukocytes, normetanephrine (NMN) and metanephrine (MN) in 75 consecutive patients...
  32. ncbi The catecholamine biosynthesis route in potato is affected by stress
    Anna Swiedrych
    Institute of Biochemistry and Molecular Biology, University of Wrocław, Przybyszewskiego Street 63 77, 51 148 Wrocław, Poland
    Plant Physiol Biochem 42:593-600. 2004
    ..In all, stress conditions the normetanephrine level and thus catecholamine catabolism was significantly decreased...
  33. ncbi Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat
    Maria S Landa
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 292:E1388-94. 2007
    ..Thus the TRH-leptin interaction may contribute to the strong association between hypertension and obesity...
  34. ncbi Predictive value of preoperative transthoracic echocardiography in patients undergoing adrenalectomy for pheochromocytoma
    B Devaux
    Department of Anaesthesia and Critical Care, université Paris V René Descartes, Hopital Cochin, Assistance Publique, Hopitaux de Paris, Paris, France
    Acta Anaesthesiol Scand 48:711-5. 2004
    ..Adrenalectomy for pheochromocytoma is a life-threatening procedure. Few echocardiographic assessments have been reported in patients undergoing adrenalectomy for pheochromocytoma...
  35. ncbi Diagnosis and localization of pheochromocytoma
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 43:907-10. 2004
    ..Consistently elevated plasma levels of free normetanephrine provided the first and only biochemical evidence for a pheochromocytoma in this case...
  36. ncbi Preparation and characterization of immunogens for antibody production against metanephrine and normetanephrine
    E C Y Chan
    Department of Pharmacy, The National University of Singapore, 18 Science Drive 4, Singapore, Singapore
    J Immunol Methods 266:143-54. 2002
    ..cross-linking procedure using active esters was successfully adopted for conjugating metanephrine (MN) and normetanephrine (NM) to bovine serum albumin (BSA)...
  37. ncbi Comparative values of catecholamines and metabolites for the diagnosis of neuroblastoma
    Maud Monsaingeon
    Service de Medecine Nucleaire, Hopital Haut Leveque, 33604 Pessac, France
    Eur J Pediatr 162:397-402. 2003
    ..b>Normetanephrine (NME), vanillylmandelic and homovanillic acids (VMA, HVA) were the best analytes...
  38. ncbi Study of diurnal fluctuations of plasma methoxyamines in healthy volunteers
    Guillaume Hoizey
    Service d endocrinologie, Hopital Robert Debre, CHU de Reims, France
    Clin Endocrinol (Oxf) 56:119-22. 2002
    We studied the diurnal fluctuations of plasma concentrations of methoxyamines (metanephrine and normetanephrine) and of their parent amines (epinephrine and norepinephrine) in normotensive subjects.
  39. ncbi Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study
    Stephan A Chalon
    Lilly Research Laboratories, Mont Saint Guibert, Belgium
    Neuropsychopharmacology 28:1685-93. 2003
    ..The lack of a detectable impact of duloxetine on TYR PD30 suggests that this may not be the most sensitive indirect measure of NE reuptake when assessing dual reuptake inhibitors...
  40. ncbi [Absence of labetalol interference on urine metanephrine determination in hypertensive patients]
    X Girerd
    , , Paris
    Arch Mal Coeur Vaiss 85:1231-4. 1992
    ..In 8 patients, a dosage of metanephrine, normetanephrine and creatinine on a 24 hours urine sample was performed before (D1) and 24 hours after (D3) the prescription ..
  41. ncbi Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery
    Hiromu Kawasaki
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Pharmacol Exp Ther 330:745-55. 2009
    ..Perfusion of adrenergic transmitter metabolites (normetanephrine and 3-methoxydopamine), but not of other metabolites, induced vasodilation, which was not inhibited by ..
  42. ncbi [Retroperitoneal laparoscopic adrenalectomy in a pregnant woman presenting MEN2a with a pheochromocytoma: case report and review of the literature]
    C Frayssinet
    Service d Endocrinologie et Maladies Métaboliques, Pôle cardiovasculaire et métabolique, CHU Rangueil Larrey, 31059, Toulouse Cedex 9, France
    Ann Endocrinol (Paris) 69:53-7. 2008
    ..firstly, all MEN2a women should be screened for a pheochromocytoma with a 24-h urinary metanephrine and normetanephrine evaluation before or early during pregnancy, even with normal blood pressure; secondly, pheochromocytoma ..
  43. ncbi Increased urinary dopamine excretion in association with bilateral carotid body tumours-- clinical, biochemical and genetic findings
    J Jeffery
    Derriford Combined Laboratory, Derriford Hospital, Plymouth PL6 8DH, UK
    Ann Clin Biochem 43:156-60. 2006
    ....
  44. pmc The electrical and mechanical responses of the rabbit saphenous artery to nerve stimulation and drugs
    J E Nally
    Department of Pharmacology, University of Glasgow
    Br J Pharmacol 105:367-75. 1992
    ..No additional electrical response was evoked by field stimulation, even in the presence of normetanephrine (NMN) and desmethylimipramine (DMI, each 10(-6) M), which block neuronal and extraneuronal uptake of ..
  45. ncbi Prostaglandin F2 alpha fails to alter the number of beta adrenoceptive specific binding sites in metestrous rat uteri but diminishes noradrenaline tissue uptake
    M Chaud
    Centro de Estudios Farmacológicos y de Principios Naturales CEFAPRIN, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Prostaglandins Leukot Essent Fatty Acids 34:95-100. 1988
    ..10(-5) M), normetanephrine (10(-6) M) or acetylsalicylic acid (ASA: 10(-4) M), were explored...
  46. ncbi Severe postoperative hypoglycemia in a patient with pheochromocytoma and preclinical Cushing's syndrome
    Darko Kastelan
    Division of Endocrinology, Department of Internal Medicine, University Hospital Zagreb, Zagreb, Croatia
    Med Sci Monit 13:CS34-7. 2007
    ..Although the mechanism of hypoglycemia is not fully understood, it seems that it is caused by excessive rebound secretion of insulin after surgical resection of pheochromocytoma...
  47. ncbi Ischemic stroke and rhabdomyolysis in a 15-year-old girl with paraganglioma due to an SDHB exon 6 (Q214X) mutation
    M S Kim
    Department ofPediatrics, Rhode Island Hospital Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr Endocrinol Metab 22:565-71. 2009
    ..Plasma total metanephrines were 232,176.4 pmol/l [263-1052] with normetanephrine predominance...
  48. pmc Measurement of urinary metanephrines to screen for pheochromocytoma in an unselected hospital referral population
    Keith L Brain
    Department of Pharmacology, University of Oxford, and Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Chem 52:2060-4. 2006
    ....
  49. ncbi Determination of levodopa and biogenic amines in urine samples using high-performance liquid chromatography
    Irena Baranowska
    Department of Analytical and General Chemistry, Silesian University of Technology, 7 M Strzody Str 44 100 Gliwice, Poland
    J Chromatogr Sci 46:30-4. 2008
    ..biogenic amines, and their metabolites from the catecholamines group: dopamine (DA), epinephrine (E), normetanephrine (NMN), metanephrine (MN), 3,4-dihydroxyphenylacetic acid (DOMA), 3-metoxy-4-hydroxyphenyl-glycol (MHPG), and ..
  50. ncbi [Does the size of pheochromocytoma influence the results of its laparoscopic excision?]
    L Brunaud
    Service de Chirurgie Digestive, endocrinienne et viscérale, CHU Nancy Brabois, 11 allee du morvan, 54511 Vandoeuvre les Nancy, France
    Ann Chir 127:362-9. 2002
    ..The aim of this study was to assess diagnostic characteristics, hemodynamic modifications, and outcome of intraperitoneal laparoscopic adrenalectomy according to the size of pheochromocytoma...
  51. ncbi Analysis of catecholamines and their metabolites in adrenal gland by liquid chromatography tandem mass spectrometry
    Qun Gu
    National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
    Anal Chim Acta 609:192-200. 2008
    ..Tyrosine, dopamine, dihydroxyphenylalanine, epinephrine, norepinephrine, 3-methoxytyramine, normetanephrine, metanephrine and isoproterenol (internal standard) were separated on a Kromasil Cyano analytical column by a ..
  52. ncbi Malignant paraganglioma associated with succinate dehydrogenase subunit B in an 8-year-old child: the age of first screening?
    Tamara Prodanov
    Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Pediatr Nephrol 24:1239-42. 2009
    ..Laboratory data included an elevated level of urine normetanephrine of 45,400 microg/g creatinine (upper reference limit 718 microg/g) and elevated level of plasma ..
  53. pmc Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli, Denizli 20070, Turkey
    Br J Pharmacol 145:1035-44. 2005
    ..92+/-0.39, epinephrine (Epi) 1.91+/-0.183, 3-methoxy-4-hydroxyphenylglycol (MHPG) 11.53+/-3.22, normetanephrine 3.26+/-0.61, dopamine (DA) 0.77+/-0.23, 3,4-dihydroxyphenylacetic acid (DOPAC) 3.37+/-1...
  54. ncbi Urinary catecholamine and metanephrine to creatinine ratios in healthy dogs at home and in a hospital environment and in 2 dogs with pheochromocytoma
    Peter H Kook
    Clinic for Small Animal Internal Medicine Vetsuisse Faculty, University of Zurich, Switzerland
    J Vet Intern Med 21:388-93. 2007
    ..Measurement of high concentrations of urine catecholamines and metanephrines is useful in diagnosing pheochromocytoma in humans. Stress increases catecholamine excretion in urine...
  55. ncbi Plasma metanephrine levels are decreased in type 1 diabetic patients with a severely impaired epinephrine response to hypoglycemia, indicating reduced adrenomedullary stores of epinephrine
    Bastiaan E De Galan
    Department of Medicine, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 89:2057-61. 2004
    ..18 +/- 0.09 vs. 0.24 +/- 0.02 nmol/liter; P = 0.012), whereas plasma epinephrine, norepinephrine, and normetanephrine levels were comparable between patients and controls...
  56. ncbi Severe polyuria after the resection of adrenal pheochromocytoma
    Musashi Tobe
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Int J Urol 17:1004-7. 2010
    ..Because the levels of urinary metanephrine and normetanephrine were elevated, and (131) I-MIBG scintigraphy showed intense uptake in the adrenal tumor, the tumor was ..
  57. ncbi Isopropanol protein precipitation for the analysis of plasma free metanephrines by liquid chromatography-tandem mass spectrometry
    Luke C Marney
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Chem 54:1729-32. 2008
    ..We sought to develop an in-house method for this expensive test..
  58. pmc Urinary catecholamines and metabolites in the immediate postoperative period following major surgery
    A A Syed
    Department of Medical Biochemistry, University Hospital of Wales, Cardiff CF14 4XW, UK
    J Clin Pathol 57:548-50. 2004
    ....
  59. ncbi Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma
    E Grouzmann
    Division d Hypertension, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Clin Chem 47:1075-82. 2001
    ..We hypothesized that the long persistence of total (sulfate-conjugated plus free) metanephrines in the blood might have a significant diagnostic value...
  60. ncbi [Change in the surgical treatment of benign adrenal gland tumors. Laparoscopic adrenalectomy]
    F Juhasz
    Debreceni Egyetem Orvos és Egészségtudományi Centrum I sz Sebészeti Klinika, 4012 Debrecen, Pf 27
    Magy Seb 54:75-9. 2001
    ..Adrenal imagery consisted in all patients of abdominal computed tomography and in 4 patients adrenal magnetic resonance imaging but [131I] metaiodobenzylguanidine (MIBG) and octreotide scintigraphy were not performed...
  61. ncbi Quantitative measurement of plasma free metanephrines by ion-pairing solid phase extraction and liquid chromatography-tandem mass spectrometry with porous graphitic carbon column
    Xiang He
    ThermoFisher Scientific, 355 River Oaks Parkway, San Jose, CA 95134, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 879:2355-9. 2011
    Plasma free metanephrine and normetanephrine are the best biomarkers for diagnosing pheochromocytoma...
  62. ncbi A simple liquid chromatography-tandem mass spectrometry method for measuring metanephrine and normetanephrine in urine
    Jessica Gabler
    Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA
    Clin Chem Lab Med 49:1213-6. 2011
    ..Liquid chromatography-tandem mass spectrometry (LC-MS/MS) represents the most specific and accurate technology for this purpose. The goal of this work was to develop a simple LC-MS/MS method for measuring metanephrines in urine...
  63. pmc Detecting pheochromocytoma: defining the most sensitive test
    Ulrich Guller
    Department of Surgery, Divisions of General Surgery and Surgical Research, University Hospital Basel, Basel, Switzerland
    Ann Surg 243:102-7. 2006
    ..To define the most sensitive biochemical test to establish the diagnosis of pheochromocytoma and also to assess the potential role of iodine 131-labeled metaiodobenzylguanidine scintigraphy (I-MIBG) in the diagnosis of this tumor...
  64. ncbi Detection of catecholamines and metanephrines by radio-immunoassay in canine plasma
    Roland C E Francis
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Vet J 183:228-31. 2010
    ..to detect epinephrine (EPI), norepinephrine (NE), and their O-methylated metabolites metanephrine (MN) and normetanephrine (NMN) in canine plasma...
  65. ncbi Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels
    M Madhavan
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Heart 95:1436-41. 2009
    ..To evaluate the stress neurohumoral and cardiac biomarker profile of patients with apical ballooning syndrome (ABS)...
  66. ncbi Plasma metanephrines in renal failure
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1620, USA
    Kidney Int 67:668-77. 2005
    ..Measurements of the plasma metanephrines, normetanephrine and metanephrine (the O-methylated metabolites of norepinephrine and epinephrine), provide an alternative ..
  67. ncbi Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine
    Graeme Eisenhofer
    Clinical Neurocardiology Section, Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, Maryland 20892 1620, USA
    J Clin Endocrinol Metab 90:2068-75. 2005
    Measurements of plasma-free normetanephrine and metanephrine provide a sensitive test for diagnosis of pheochromocytoma but may fail to detect tumors that produce predominantly dopamine...
  68. ncbi Determination of urinary catecholamines with capillary electrophoresis after solid-phase extraction
    K Vuorensola
    Technical Research Center of Finland, Chemical Technology, VTT ESPOO
    J Chromatogr A 895:317-27. 2000
    The stabilities of 3,4-dihydroxybenzylamine (DHBA), dopamine, 3-methoxytyramine, normetanephrine and metanephrine standards under acid, base and enzymatic hydrolysis conditions were studied...
  69. ncbi Temporal and periovulatory changes in ovarian catecholamines in the catfish Heteropneustes fossilis
    V Singh
    Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Gen Comp Endocrinol 168:46-54. 2010
    ..NE activity or turnover index (ratio of NE to normetanephrine, NME) increased during the recrudescent phase to give the peak in the spawning phase and decreased in the ..
  70. ncbi Rotational stress-induced increase in epinephrine levels delays cutaneous wound healing in mice
    Bruna Romana-Souza
    Department of Histology and Embryology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Brain Behav Immun 24:427-37. 2010
    ..Stressed mice exhibited reduced locomotor activity and increased normetanephrine plasma levels...
  71. ncbi Posttraumatic hypertension secondary to adrenal hemorrhage mimicking pheochromocytoma: case report
    J Schmidt
    Department of Surgery, University Witten Herdecke, Wuppertal, Germany
    J Trauma 46:973-5. 1999
    ..4 cm in size located in the right adrenal gland together with extreme hypertension, tripled urine levels for normetanephrine, and normal plasmatic levels of metanephrines. The patient had suffered a fall from a height of 2...
  72. ncbi Association of adrenal medullar and cortical nodular hyperplasia: a report of two cases with clinical and morpho-functional considerations
    Gloria Valdes
    Departamentos de Nefrología, Anatomia Patologica, Endocrinologia, Urologia, y Radiología, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Endocrine 30:389-96. 2006
    ..associated to a left adrenal node, normal cortisol and aldosterone:renin ratio, marginally increased urinary normetanephrine, and a positive 131I MIBG radioisotope scan...
  73. ncbi Study of catecholamines in patient urine samples by capillary electrophoresis
    H Siren
    Academy of Finland, Espoo, Finland
    J Chromatogr A 853:527-33. 1999
    ..The method was optimized with reference compounds 3,4-dihydroxybenzylamine, adrenaline, noradrenaline, normetanephrine, dopamine, dopac (homogensitic acid), methanephrine, vanillyl-mandelic acid, 5-hydroxyindoleacetic acid (5-..
  74. ncbi Plasma chromogranin A levels are increased in a small portion of patients with hereditary head and neck paragangliomas
    Nicolette van Duinen
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 74:160-5. 2011
    ..The majority of patients with head and neck paragangliomas (HNPGL) have biochemically silent tumours. Chromogranin A (CgA) is a tumour marker for neuroendocrine tumours...
  75. ncbi Phaeochromocytoma in pregnancy
    S Grodski
    Department of Surgey, St Vincent s Hospital, Melbourne, Victoria, Australia
    Intern Med J 36:604-6. 2006
    ..of phaeochromocytoma is achieved by detecting increased catecholamines and metabolites (metanephrine and normetanephrine) on 24-h urine collection, as these levels are unaffected by pregnancy or pre-eclampsia...
  76. ncbi Hormonal changes during 17 days of head-down bed-rest
    Marc Antoine Custaud
    Laboratoire de Physiologie de l Environnement GIP exercice, Faculte de Medecine Lyon Grange Blanche, 8 avenue Rockefeller, F 69373 Lyon Cedex 08, France
    Life Sci 72:1001-14. 2003
    ..A decrease during the night was noted for normetadrenaline urinary derivates, but only during the HDBR...
  77. ncbi Synthesis and characterization of an immobilized phenylethanolamine N-methyltransferase liquid chromatographic stationary phase
    N Markoglou
    Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Anal Biochem 288:83-8. 2001
    ..The results demonstrate that the PNMT-SP can be utilized for the rapid screening of potential PNMT substrates as well as the screening of compounds for PNMT inhibitory activity...
  78. ncbi Urine of patients with acute kidney transplant rejection show high normetanephrine and decreased 2-hydroxyestrogens concentrations
    S W Reinhold
    Klinik und Poliklinik fur Innere Medizin II, Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Transplant Proc 45:1503-7. 2013
    ....
  79. ncbi [Diffuse uptake of brown fat on computed-tomography coupled positron emission tomoscintigraphy (PET-CT) for the exploration of extra-adrenal pheochromocytoma]
    C Ramacciotti
    Service d endocrinologie, diabète et maladies métaboliques, Hopital Civil, CHU Strasbourg, France
    Ann Endocrinol (Paris) 67:14-9. 2006
    ..The norepinephrine level reached 49.7 nmol/l (<4.00) and urinary norepinephrine and normetanephrine levels reached 13977 nmol/24h (<414) and 32 micromol/24h (0.4-2.5) respectively...
  80. pmc False-negative ¹²³I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease
    Jay S Fonte
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 19:83-93. 2012
    ..The majority of patients had extraadrenal tumors with hypersecretion of normetanephrine or norepinephrine...
  81. pmc Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3)
    John J Mooney
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 42:605-11. 2008
    ..Desipramine treatment produced significant increases in urinary norepinephrine (NE) and normetanephrine (NMN) and plasma NE at Weeks 4 and 6, but not at Week 1...
  82. ncbi Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions
    Roland Därr
    Department of Medicine III, University Hospital Dresden at the TU Dresden, Dresden, Germany
    Clin Endocrinol (Oxf) 80:478-86. 2014
    ..the influences of blood sampling under supine fasting versus seated nonfasting conditions on diagnosis of phaeochromocytomas and paragangliomas (PPGL) using plasma concentrations of normetanephrine, metanephrine and methoxytyramine.
  83. ncbi Lack of enantioselectivity in the SULT1A3-catalyzed sulfoconjugation of normetanephrine enantiomers: an in vitro and computational study
    Eric Grouzmann
    Service de biomédecine, Lausanne University Hospital, Lausanne, Switzerland
    Chirality 25:28-34. 2013
    1R)-Normetanephrine is the natural stereoisomeric substrate for sulfotransferase 1A3 (SULT1A3)-catalyzed sulfonation...
  84. ncbi Multicenter study on the diagnostic value of a new RIA for the detection of free plasma metanephrines in the work-up for pheochromocytoma
    Tomas Lenz
    Kuratorium für Dialyse und Nierentransplantation e V Kidney Center, Ludwigshafen, Germany
    Ann N Y Acad Sci 1073:358-73. 2006
    ..Good agreement of the assay with the tandem mass spectrometry (LC-MS/MS) method for normetanephrine (r2=0.975) and for metanephrine (r2=0.985) could be demonstrated...
  85. ncbi Phasing-in plasma metanephrines determination
    Julie Brossaud
    Department of Nuclear Medicine, CHU de Bordeaux, F 33604 PESSAC, France
    Eur J Endocrinol 169:163-70. 2013
    We set up plasma normetanephrine (pNMA) and metanephrine (pMA) assays as they demonstrated their usefulness for diagnosing phaeochromocytomas...
  86. ncbi The use of plasma metanephrine to normetanephrine ratio to determine epinephrine poisoning
    Dustin C Yaworsky
    Microchemistry Laboratory, University of Connecticut, Storrs, CT 06269, United States
    Clin Chim Acta 353:31-44. 2005
    ..We measured plasma epinephrine metabolites (metanephrine, MET, and normetanephrine, NMET) to determine if exogenous epinephrine can be distinguished from endogenous epinephrine concentrations ..
  87. ncbi [Pheochromocytoma in end-stage renal disease patient treated by peritoneal dialysis]
    Imen Gorsane
    Service de néphrologie et de médecine interne A, Hopital Charles Nicolle, Boulevard 9 avril, BS 1006, Tunis, Tunisie
    Nephrol Ther 4:597-601. 2008
    ..We conclude that refractory hypertension, as a possible diagnosis, is uncommon in peritoneal dialysis patients. Pheochromocytoma must be eliminated by careful evaluation...
  88. ncbi Rapid analysis of metanephrine and normetanephrine in urine by gas chromatography-mass spectrometry
    David K Crockett
    ARUP Laboratories, Inc, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    Clin Chem 48:332-7. 2002
    Widely used HPLC methods for quantification of metanephrine and normetanephrine in urine often have long analysis times and are frequently plagued by drug interferences...
  89. ncbi Paracetamol-associated interference in an HPLC-ECD assay for urinary free metadrenalines and catecholamines
    Fraser D Davidson
    Biochemistry Department, Crosshouse Hospital, Kilmarnock KA2 0BE, UK
    Ann Clin Biochem 41:316-20. 2004
    ..Prime amongst these interferences are those due to paracetamol ingestion...
  90. ncbi Evaluation of specific high-performance liquid-chromatographic determinations of urinary adrenaline and noradrenaline by comparison with isotope dilution mass spectrometry
    J J Willemsen
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, The Netherlands
    Ann Clin Biochem 38:356-64. 2001
    ..Sex differences were detected for MA and NMA excretion when expressed in nmol per 24 h and nmol/mmol creatinine, respectively, by both ECD and GC-MS methods...
  91. ncbi Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction
    Noritaka Kawada
    Cardiovascular Kidney Institute, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 2197, USA
    Hypertension 45:1131-8. 2005
    ..01) in nitrate plus nitrite (NOx), and a 52% increase in metanephrine (P<0.02). The excretion of normetanephrine, a marker for sympathetic nervous activity, was reduced during ST in COX-1(+/+) (6.9+/-0.9 versus 3.2+/-0...
  92. ncbi CPAP and measures of cardiovascular risk in males with OSAS
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford, OX3 7LJ, UK
    Eur Respir J 32:1488-96. 2008
    ..After 4 weeks of therapeutic CPAP, significant reductions were seen in urine normetanephrine excretion (from mean+/-sd 179.7+/-80.1 to 132.7+/-46...
  93. ncbi Urinary catecholamine and metadrenaline to creatinine ratios in dogs with a phaeochromocytoma
    P H Kook
    Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    Vet Rec 166:169-74. 2010
    ..Urine normetadrenaline:creatinine ratios may be useful in the diagnosis of canine phaeochromocytomas...
  94. ncbi Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
    Ai Ming Yu
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacogenetics 13:307-19. 2003
    ..2-phenylethylamine, octopamine, synephrine, 3-methoxy-p-tyramine, 4-methoxy-m-tyramine, metanephrine, and normetanephrine, nor the indolethylamines tryptamine, serotonin, 6-methoxytryptamine, and melatonin, nor the beta-carbolines ..
  95. pmc Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
    Jamie C M Lam
    Department of Medicine, Queen Mary Hospital, Hong Kong, SAR China
    Sleep 31:1721-7. 2008
    ..This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants...
  96. ncbi The relation of adiponectin and tumor necrosis factor alpha levels between endothelial nitric oxide synthase, angiotensin-converting enzyme, transforming growth factor beta, and tumor necrosis factor alpha gene polymorphism in adrenal incidentalomas
    E Harman
    Division of Internal Medicine, Division of Endocrinology, Ege University Hospital, 35100 Izmir, Turkey
    J Endocrinol Invest 32:881-8. 2009
    ....
  97. ncbi Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005
    Karel Pacak
    National Institute of Child Health and Development, NIH, Bethesda, MD, USA
    Nat Clin Pract Endocrinol Metab 3:92-102. 2007
    ..Inadequate methods to distinguish malignant from benign tumors and a lack of effective treatments for malignancy are important problems requiring further resolution...
  98. ncbi Biosynthesis in an on-line immobilized-enzyme reactor containing phenylethanolamine N-methyltransferase in single-enzyme and coupled-enzyme formats
    Nektaria Markoglou
    Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    J Chromatogr A 948:249-56. 2002
    ..The activity of the PNMT-IMER and its applicability for on-line N-methylation of normetanephrine was investigated...
  99. ncbi A rapid assay method for catechol-O-methyltransferase activity by flow injection analysis
    Nozomi Aoyama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biomed Chromatogr 16:255-60. 2002
    ..The method was based on the determination of normetanephrine, the 3-O-methyl metabolite of the substrate norepinephrine...
  100. ncbi Olfactory sensitivity to catecholamines and their metabolites in the goldfish
    P C Hubbard
    Centro de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8000 810 Faro, Portugal
    Chem Senses 28:207-18. 2003
    ..The current study raises the possibility that release of catecholamines or their 3-O-methoxy metabolites to the water may play a role in chemical communication...
  101. pmc Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma
    Christina Pamporaki
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at the TU Dresden, Fetscherstrasse 74, Dresden, Germany
    Clin Endocrinol (Oxf) 79:476-83. 2013
    The diagnosis of phaeochromocytoma is commonly performed by the measurements of plasma-free normetanephrine and metanephrine...

Research Grants2

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..examine differences in urinary markers of catecholamine release (vanillyl mandelic acid, metanephrines and normetanephrine), and in plasma levels of atrial natriuretic factor, a marker of atrial stretch...
  2. NEUROCHEMICAL & HORMONAL FACTORS IN STRESS
    ADRIAN DUNN; Fiscal Year: 1990
    ..These are: for NE, normetanephrine and 3-methoxy, 4-hydroxyphenylglycol (MHPG); for DA, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (..