leukocidins

Summary

Summary: Substances that are toxic to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.

Top Publications

  1. ncbi Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
    G Lina
    Centre National de Référence de Toxémies Staphylococciques, Faculte de Medecine, 69372 Lyon Cedex 08, France
    Clin Infect Dis 29:1128-32. 1999
  2. ncbi Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
    Juliane Bubeck Wardenburg
    Nat Med 13:1405-6. 2007
  3. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
  4. pmc Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 107:5587-92. 2010
  5. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
  6. pmc Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains
    Min Li
    Department of Laboratory Medicine, Huashan Hospital, Shanghai 200040, People s Republic of China
    J Infect Dis 202:1866-76. 2010
  7. ncbi Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner
    Magali Perret
    Universite de Lyon, France
    Cell Microbiol 14:1019-36. 2012
  8. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
  9. pmc Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities
    G Prevost
    Institut de Bacteriologie de la Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    Infect Immun 63:4121-9. 1995
  10. pmc Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
    Anne Laure Genestier
    Centre National de Référence des Staphylocoques, INSERM E0230, Lyon, France
    J Clin Invest 115:3117-27. 2005

Detail Information

Publications267 found, 100 shown here

  1. ncbi Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
    G Lina
    Centre National de Référence de Toxémies Staphylococciques, Faculte de Medecine, 69372 Lyon Cedex 08, France
    Clin Infect Dis 29:1128-32. 1999
    ..It thus appears that PVL is mainly associated with necrotic lesions involving the skin or mucosa...
  2. ncbi Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
    Juliane Bubeck Wardenburg
    Nat Med 13:1405-6. 2007
  3. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
    ..Although the toxin may be a highly linked epidemiological marker for CA-MRSA strains, we conclude that PVL is not the major virulence determinant of CA-MRSA...
  4. pmc Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 107:5587-92. 2010
    ..These findings provide insights into the mechanism of PVL-induced lung injury and inflammation and demonstrate the utility of the rabbit for studying PVL-mediated pathogenesis...
  5. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
    ..Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA...
  6. pmc Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains
    Min Li
    Department of Laboratory Medicine, Huashan Hospital, Shanghai 200040, People s Republic of China
    J Infect Dis 202:1866-76. 2010
    ..Our study indicates a major but not exclusive impact of virulence on the epidemiological success of USA300 and other CA-MRSA strains and emphasizes the importance of core genome-encoded toxins in CA-MRSA skin infections...
  7. ncbi Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner
    Magali Perret
    Universite de Lyon, France
    Cell Microbiol 14:1019-36. 2012
    ....
  8. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
  9. pmc Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities
    G Prevost
    Institut de Bacteriologie de la Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    Infect Immun 63:4121-9. 1995
    ..Only three were hemolytic on rabbit erythrocytes, the two gamma-hemolysin combinations and the combination LukF-PV-HlgA...
  10. pmc Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
    Anne Laure Genestier
    Centre National de Référence des Staphylocoques, INSERM E0230, Lyon, France
    J Clin Invest 115:3117-27. 2005
    ....
  11. pmc Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils
    Bettina Löffler
    Institute of Medical Microbiology, University Hospital of Munster, Germany
    PLoS Pathog 6:e1000715. 2010
    ....
  12. pmc Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals
    Yudong Liu
    Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing
    Antimicrob Agents Chemother 53:512-8. 2009
    ..The prevalence of the Panton-Valentine leukocidin gene was 2.3%. The data documented two major epidemic MRSA clones, ST239-MRSA-SCCmec type III and ST5-MRSA-SCCmec type II, with unique geographic distributions across China...
  13. ncbi Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine, Carl Gustav Carus at the Technical University of Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    Vet Microbiol 125:128-40. 2007
    ..The presence of these two strains highlights the possibility of transfers of S. aureus strains between different host species...
  14. pmc Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?
    Francois Vandenesch
    Bacterial Pathogenesis and Innate Immunity Laboratory, Inserm U851 Immunity, Infection and Vaccination, Lyon, France
    Front Cell Infect Microbiol 2:12. 2012
    ..In this review, we describe the hemolysins, the bi-component leukocidins (which include the Panton Valentine leukocidin, LukAB/GH, and LukED), and the cytolytic peptides (phenol ..
  15. pmc Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease
    Juliane Bubeck Wardenburg
    Department of Microbiology, University of Chicago, Chicago, Illinois, USA
    J Infect Dis 198:1166-70. 2008
    ..The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice...
  16. ncbi Bacterial two-component and hetero-heptameric pore-forming cytolytic toxins: structures, pore-forming mechanism, and organization of the genes
    Jun Kaneko
    Department of Microbial Biotechnology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 68:981-1003. 2004
    ..We also discuss the current status of knowledge of the genetic organization of PVL-converting phages in order to achieve an understanding of their molecular evolution...
  17. pmc Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease
    A Holmes
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, London, NW9 5HT, United Kingdom
    J Clin Microbiol 43:2384-90. 2005
    ..aureus and belonged to 12 different sequence types, including ST22 and ST30, which are closely related to the most prevalent MRSA clones in United Kingdom hospitals, EMRSA-15 and EMRSA-16, respectively...
  18. ncbi Complete nucleotide sequence and molecular characterization of the temperate staphylococcal bacteriophage phiPVL carrying Panton-Valentine leukocidin genes
    J Kaneko
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai 981 8555, Japan
    Gene 215:57-67. 1998
    ..aureus bacteriophages. The phiPVL genome was found to integrate into an ORF encoding an unknown protein comprising 725 amino acid residues with two leucine zipper-like motifs...
  19. pmc Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus
    Birgit Walther
    Institute of Microbiology and Epizootics IMT, Free University Berlin, Philippstrasse 13, 10115 Berlin, Germany
    J Clin Microbiol 47:704-10. 2009
    ..These data provide evidence for the adaptation of certain MRSA genotypes to more than one mammalian species, reflecting their extended host spectra...
  20. pmc Panton-valentine leukocidin enhances the severity of community-associated methicillin-resistant Staphylococcus aureus rabbit osteomyelitis
    Anne Claude Cremieux
    Département de médecine aiguë, Hôpital Universitaire Raymond Poincaré, Assistance Publique Hopitaux de Paris, Garches, France
    PLoS ONE 4:e7204. 2009
    ..However, the pathogenetic role of PVL in staphylococcal infections remains controversial, possibly because it depends on the site of infection...
  21. ncbi Methicillin-susceptible, non-multiresistant methicillin-resistant and multiresistant methicillin-resistant Staphylococcus aureus infections: a clinical, epidemiological and microbiological comparative study
    W J Munckhof
    Infection Management Service, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, Brisbane, Queensland, Australia 4102
    Eur J Clin Microbiol Infect Dis 27:355-64. 2008
    ..Patients with PVL-positive infections were much younger than patients with PVL-negative infections. The proportion of PVL-positive infections peaked in the 10-29 years old age group, followed by a linear decline...
  22. pmc Incidence, risk factors, and outcomes of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus infections in Auckland, New Zealand
    S Muttaiyah
    Department of Microbiology, Auckland City Hospital, Grafton, Auckland, New Zealand
    J Clin Microbiol 48:3470-4. 2010
    ..Those patients with PVL-positive MSSA infection were more likely to be of Pacific ethnicity, be younger in age, have community-onset infection, have SSTI, and need surgical intervention...
  23. pmc The role of virulence determinants in community-associated MRSA pathogenesis
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, 1001 Potrero Avenue, Box 0811, San Francisco, CA 94110, USA
    Trends Microbiol 16:361-9. 2008
    ..Here, we discuss the roles of PVL, the arginine catabolic mobile element and phenol-soluble modulins in the pathogenesis of prevalent CA-MRSA strains...
  24. pmc Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury
    Ching Wen Tseng
    Division of Pediatric Infectious Diseases and the Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    PLoS ONE 4:e6387. 2009
    ..PVL could contribute to the increased incidence of myositis in CA-MRSA infection, and the toxin could mediate tissue injury by mechanisms other than direct killing of phagocytes...
  25. ncbi Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus
    Bruno Dohin
    Services de Chirurgie Pédiatrique, Hopital Edouard Herriot, Universite Claude Bernard Lyon 1, Cedex, France
    Pediatr Infect Dis J 26:1042-8. 2007
    ..Panton-Valentine leukocidin (PVL) is a necrotizing toxin secreted by Staphylococcus aureus. PVL-positive S. aureus osteomyelitis and arthritis have been described...
  26. ncbi Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients
    Yves Gillet
    Division of Paediatric Intensive Care, Hopital Edouard Herriot, Lyon, France
    Lancet 359:753-9. 2002
    ..We aimed to assess the clinical features of these eight cases, and those of other cases identified prospectively, and to compare them with the characteristics of patients with pneumonia caused by PVL-negative strains...
  27. ncbi Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia
    Maria Labandeira-Rey
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Science 315:1130-3. 2007
    ....
  28. pmc Flow cytometric determination of Panton-Valentine leucocidin S component binding
    V Gauduchon
    , , , 67000 Strasbourg, France
    Infect Immun 69:2390-5. 2001
    ..The labeled mutant form of LukS-PV has proved very useful for detailed binding studies of circulating white cells by flow cytometry. LukS-PV possesses a high specific affinity for a unique receptor on PMNs and monocytes...
  29. pmc Novel multiplex PCR assay for detection of the staphylococcal virulence marker Panton-Valentine leukocidin genes and simultaneous discrimination of methicillin-susceptible from -resistant staphylococci
    Jo Ann McClure
    Centre for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Calgary, Alberta, Canada
    J Clin Microbiol 44:1141-4. 2006
    ..This assay is simple, rapid, and accurate and offers the potential for prompt detection of newly emerging community-associated methicillin-resistant Staphylococcus aureus...
  30. pmc Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: a role for panton-valentine leukocidin?
    Christopher P Montgomery
    Section of Critical Care Medicine, Department of Pediatrics, University of Chicago, 5841 S Maryland Ave, MC 1145, Chicago, IL 60637, USA
    Infect Immun 77:2159-67. 2009
    ..Deletion of lukSF-PV did not alter the early immune response to CA-MRSA in the lung...
  31. pmc The molecular epidemiology of the highly virulent ST93 Australian community Staphylococcus aureus strain
    Geoffrey W Coombs
    Australian Collaborating Centre for Enterococcus and Sdtaphylococcus Species ACCESS Typing and Research, PathWest Laboratory Medicine Western Australia, Royal Perth Hospital, Western Australia, Australia
    PLoS ONE 7:e43037. 2012
    ..Whether ST93-IVa [2B] t202-dt10 arose from one PVL-positive ST93-MSSA-t202, or by independent acquisitions of SCCmec-IVa [2B]-dt10 into multiple PVL-positive ST93-MSSA-t202 strains is not known...
  32. ncbi Comparative molecular analysis of community-associated and healthcare-associated methicillin-resistant Staphylococcus aureus isolates from children in northern Taiwan
    Y C Huang
    Division of Paediatric Infectious Diseases, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Clin Microbiol Infect 14:1167-72. 2008
    ..However, the CA clone of ST59 was also identified in a substantial proportion of HA isolates...
  33. ncbi The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins
    J D Pedelacq
    Groupe de Cristallographie Biologique Institut de Pharmacologie et de Biologie Structurale du CNRS 205 route de Narbonne 31077 Toulouse Cedex France
    Structure 7:277-87. 1999
    ..The components of each protein class are produced as non-associated, water-soluble proteins that undergo conformational changes and oligomerization after recognition of their cell targets...
  34. ncbi Purification, cloning and characterization of variant LukE-LukD with strong leukocidal activity of staphylococcal bi-component leukotoxin family
    Naoko Morinaga
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Chiba 260 8670, Japan
    Microbiol Immunol 47:81-90. 2003
    ..The lukEv-IukDv was found in 87% of clinical isolates of Staphylococcus aureus but lukE-lukD was not detected. These data demonstrate the existence of variant LukE-LukD in V8 strain (ATCC 27733)...
  35. pmc Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e3198. 2008
    ..Taken together, our data indicate a modest and transient positive effect of PVL in the acute phase of bacteremia, thereby providing evidence that PVL contributes to CA-MRSA pathogenesis...
  36. ncbi Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England
    L J Shallcross
    Research Department of Infection and Population Health, University College London, UK
    Clin Microbiol Infect 16:1644-8. 2010
    ..Consideration should be given to current infection control strategy, which advocates household contact screening and decolonization on the assumption that PVL-associated disease is rare...
  37. pmc Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection
    Pauline Yoong
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:2241-6. 2010
    ..Given the high rates of primary and recurring MRSA infections in humans, it appears that antibodies to PVL might contribute to host susceptibility to infection...
  38. ncbi Methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized children: correlation of molecular analysis with clinical presentation and antibiotic susceptibility testing (ABST) results
    N Abdel-Haq
    Children s Hospital of Michigan, Detroit, 48201, USA
    Eur J Clin Microbiol Infect Dis 28:547-51. 2009
    ..Most USA300 were susceptible (S) to clindamycin (CD) and patients were treated with CD alone or in combination. The other isolates were generally treated with vancomycin (VA) alone or in combination...
  39. ncbi Molecular characteristics of community-acquired methicillin-resistant Staphylococcus aureus in Hokkaido, northern main island of Japan: identification of sequence types 6 and 59 Panton-Valentine leucocidin-positive community-acquired methicillin-resistant
    Mitsuyo Kawaguchiya
    Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan
    Microb Drug Resist 17:241-50. 2011
    ..These findings suggest a potential spread of these emerging CA-MRSA clones in Japan...
  40. pmc Emergence of hospital- and community-associated panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus genotype ST772-MRSA-V in Ireland and detailed investigation of an ST772-MRSA-V cluster in a neonatal intensive care unit
    Gráinne I Brennan
    National MRSA Reference Laboratory, St James s Hospital, Dublin, Ireland
    J Clin Microbiol 50:841-7. 2012
    ..Our study indicates that hospital-acquired and CA-ST772-MRSA-V is currently emerging in Ireland and may have been imported from India on several occasions...
  41. pmc Community-associated methicillin-resistant Staphylococcus aureus isolated in Finland in 2004 to 2006
    Mari Kanerva
    National Institute for Health and Welfare, Department of Infectious Disease Epidemiology and Control, Helsinki, Finland
    J Clin Microbiol 47:2655-7. 2009
    ..9/100,000 population) and strain variation increased in comparison to years 1997 to 1999. There were 7 community-associated epidemic and 25 sporadic MRSA strain types. Half of these had Panton-Valentine leukocidin genes...
  42. ncbi Identification of the third type of PVL phage in ST59 methicillin-resistant Staphylococcus aureus (MRSA) strains
    Meng Zhang
    Department of Infection Control Science, Graduate School of Medicine, Juntendo University, Tokyo, Japan
    FEMS Microbiol Lett 323:20-8. 2011
    ....
  43. ncbi Virulence factors and genotypes of Staphylococcus aureus from infection and carriage in Gabon
    F Schaumburg
    Institute of Medical Microbiology, University Hospital Munster, Munster, Germany
    Clin Microbiol Infect 17:1507-13. 2011
    ..aureus isolates from asymptomatic carriers and infections. Of note, S. aureus isolates from Gabon show a very high prevalence of PVL-encoding genes, which exceeds the rates observed for developed countries...
  44. ncbi Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes
    S Breurec
    Institut Pasteur, Dakar, Senegal
    Clin Microbiol Infect 17:633-9. 2011
    ..This overrepresentation of PVL in MSSA could lead to the emergence and spread of successful, highly virulent PVL-positive MRSA clones, a phenomenon that has already started in Africa...
  45. pmc Emergence and dissemination of a community-associated methicillin-resistant Panton-Valentine leucocidin-positive Staphylococcus aureus clone sharing the sequence type 5 lineage with the most prevalent nosocomial clone in the same region of Argentina
    Claudia Sola
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET, Ciudad Universitaria, Pabellon Argentina, Cordoba, Argentina
    J Clin Microbiol 46:1826-31. 2008
    ....
  46. ncbi Community-associated methicillin-resistant Staphylococcus aureus, eastern Argentina
    Noella Gardella
    Catedra de Microbiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
    Diagn Microbiol Infect Dis 62:343-7. 2008
    ..Representative isolates were characterized by multilocus sequence typing and spa typing, demonstrating that this clone belonged to ST5 and spa type 311...
  47. pmc Familial furunculosis associated with community-acquired leukocidin-positive methicillin-susceptible Staphylococcus aureus ST152
    E Perez-Roth
    Unidad de Investigacion, Hospital Universitario NS Candelaria, Ctra del Rosario 100, 38010 Santa Cruz de Tenerife, Spain
    J Clin Microbiol 48:329-32. 2010
    ..aureus ST152 isolates associated with severe clinical symptoms are herein described. Remarkably, ST152 isolates usually are methicillin resistant...
  48. pmc Cooccurrence of predominant Panton-Valentine leukocidin-positive sequence type (ST) 152 and multidrug-resistant ST 241 Staphylococcus aureus clones in Nigerian hospitals
    Kenneth O Okon
    Department of Medical Microbiology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
    J Clin Microbiol 47:3000-3. 2009
    ..aureus (MSSA) isolates were observed. The cooccurrence of multidrug-resistant MRSA and PVL-positive MSSA isolates entails the risk of emergence of a multidrug-resistant PVL-positive MRSA clone...
  49. ncbi Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007
    Jean Philippe Rasigade
    Universite Lyon 1, Centre National de Référence des Staphylocoques, and Institut National de la Santé et de la Recherche Médicale U851, Institut Fédératif de Recherche 128, Lyon, France
    J Infect Dis 201:1589-97. 2010
    ..The epidemiological profile of PVL-positive community-acquired (CA) MRSA has been extensively studied, but few corresponding data on PVL-positive MSSA are available...
  50. pmc Molecular characterization of methicillin-resistant Staphylococcus aureus with emergence of epidemic clones of sequence type (ST) 22 and ST 772 in Mumbai, India
    Namita D'Souza
    Department of Microbiology, 5th Floor, S1 building, P D Hinduja National Hospital and Medical Research Center, Veer Savarkar Marg, Mahim, Mumbai 400016, Maharashtra, India
    J Clin Microbiol 48:1806-11. 2010
    ..The PVL gene-positive methicillin-sensitive S. aureus (MSSA) strains were ST 30 and were postulated to be related to the penicillin-resistant S. aureus phage type 80/81, notorious for its virulence in the 1950s...
  51. ncbi Molecular characterization of Staphylococcus aureus in Lebanon
    S T Tokajian
    Department of Biology, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon
    Epidemiol Infect 138:707-12. 2010
    ..The majority of the PVL-positive isolates (53%) were ST80-MRSA-IVc. Systematic surveillance of both hospital and community isolates in Lebanon together with measures designed to limit the spread are required...
  52. pmc Analysis of the specificity of Panton-Valentine leucocidin and gamma-hemolysin F component binding
    Florent Meyer
    Laboratoire de Physiopathologie des Interactions Hôte Bactérie, EA3432, Institut de Bactériologie, Universite Louis Pasteur, 3 Rue Koeberle, Strasbourg, F 67000 France
    Infect Immun 77:266-73. 2009
    ..In contrast, the active HlgB molecules were the HlgB molecules bound after addition of LukS-PV. In conclusion, LukF-PV must be linked to LukS-PV and to a binding site of the membrane to have toxin activity...
  53. ncbi TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo
    Ana Zivkovic
    Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    J Immunol 186:1608-17. 2011
    ..These results highlight the proinflammatory properties of PVL and identify CD14/TLR2 as an essential receptor complex for PVL-induced lung inflammation...
  54. pmc Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational tr
    In Gyu Bae
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 47:3952-7. 2009
    ..05). This contemporary, international study demonstrates that pvl was not the primary determinant of outcome in patients with MRSA cSSSI...
  55. ncbi Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel
    R Olson
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Struct Biol 6:134-40. 1999
    ....
  56. ncbi Community-associated methicillin-resistant Staphylococcus aureus (MRSA) in Australia
    Graeme R Nimmo
    Division of Microbiology, Pathology Queensland Central Laboratory, Herston Hospitals Campus, Herston, Queensland 4029, Australia
    Int J Antimicrob Agents 31:401-10. 2008
    ..Of particular concern, healthcare-associated acquisition of CA-MRSA clones is now increasing, although major hospital outbreaks have not occurred yet...
  57. pmc Prevalence and clonality of methicillin-resistant Staphylococcus aureus (MRSA) in the Atlantic Azores islands: predominance of SCCmec types IV, V and VI
    T Conceição
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
    Eur J Clin Microbiol Infect Dis 29:543-50. 2010
    ....
  58. pmc Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin
    Binh An Diep
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720, USA
    J Clin Microbiol 42:2080-4. 2004
    ..0001). There is evidence of clonal replacement over the period from 1999 to 2002, with one of these two clonal groups being supplanted by the other...
  59. ncbi Comparative genomics and DNA array-based genotyping of pandemic Staphylococcus aureus strains encoding Panton-Valentine leukocidin
    S Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Clin Microbiol Infect 13:236-49. 2007
    ..The DNA microarray technique provides a valuable epidemiological tool for the detailed characterisation of clinical isolates and comparison of strains at a global level...
  60. ncbi Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin
    Susan Boyle-Vavra
    Department of Pediatrics, Section of Infectious Diseases, University of Chicago, Chicago, IL 60637, USA
    Lab Invest 87:3-9. 2007
    ..The second aim is to outline the progress in understanding the role of PVL in CA-MRSA pathogenesis...
  61. pmc Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: evaluation from the CANVAS studies
    Amy Tong
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e37212. 2012
    ..The results of this contemporary, international study suggest that pvl presence was not the primary determinant of outcome in patients with cSSSI due to either MRSA or MSSA...
  62. pmc Sporadic "transitional" community-associated methicillin-resistant Staphylococcus aureus strains from health care facilities in the United States
    Jennifer M Brady
    Molecular Microbiology Laboratory, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
    J Clin Microbiol 45:2654-61. 2007
    ..The potential role of PVL-carrying phages and plasmids in the success of CA-MRSA clones has been discussed...
  63. pmc The emergence and importation of diverse genotypes of methicillin-resistant Staphylococcus aureus (MRSA) harboring the Panton-Valentine leukocidin gene (pvl) reveal that pvl is a poor marker for community-acquired MRSA strains in Ireland
    Angela S Rossney
    National MRSA Reference Laboratory, St James s Hospital, James s St, Dublin 8, Ireland
    J Clin Microbiol 45:2554-63. 2007
    ..3, and the remaining 11 isolates could not be subtyped. This study demonstrates that pvl is not a reliable marker for CA-MRSA in Ireland and reveals the emergence and importation of diverse genotypes of pvl-positive MRSA in Ireland...
  64. ncbi High prevalence of methicillin-resistant Staphylococcus aureus clone ST80-IV in hospital and community settings in Algiers
    K Antri
    Centre Hospitalo Universitaire Mustapha Bacha, Algiers, Algeria Université Lyon 1, Lyon Hospices Civils de Lyon, Bron, France
    Clin Microbiol Infect 17:526-32. 2011
    ..7% and 18.5%, respectively), but low (2.7%) among patients attending the outpatient clinic. The European PVL-positive C-MRSA clone ST80-IV is widespread in the Algiers hospital and community settings...
  65. ncbi Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia
    Steven Y C Tong
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Infect Dis 202:760-9. 2010
    ..Regional differences in the prevalence of Panton-Valentine leukocidin (PVL) and PVL isoform-harboring strains as well as in the local population structure of Staphylococcus aureus may influence the clinical spectrum of S. aureus infections...
  66. pmc Prevalence and sequence variation of panton-valentine leukocidin in methicillin-resistant and methicillin-susceptible staphylococcus aureus strains in the United States
    Megan L Brown
    Department of Computational Biology, GlaxoSmithKline, Collegeville, Pennsylvania, USA
    J Clin Microbiol 50:86-90. 2012
    ....
  67. pmc Panton-Valentine leukocidin does play a role in the early stage of Staphylococcus aureus skin infections: a rabbit model
    Urszula Lipinska
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 6:e22864. 2011
    ..Further, they support the epidemiological link between PVL producing S. aureus strains and necrotizing skin infections...
  68. pmc Detection and quantification of Panton-Valentine leukocidin in Staphylococcus aureus cultures by ELISA and Western blotting: diethylpyrocarbonate inhibits binding of protein A to IgG
    Hien M Nguyen
    Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States
    J Immunol Methods 356:1-5. 2010
    ..In Western blotting, the presence of DEPC prevented the binding of detecting antibody to Spa. These modified ELISA and Western blot techniques should prove useful for detecting and quantifying proteins in S. aureus culture supernatants...
  69. ncbi Brain abscess due to Panton-Valentine leukocidin-positive Staphylococcus aureus
    A Ramos
    Department of Internal Medicine Infectious Diseases Unit, Spanish Network for Research in Infectious Disease, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, San Martin de Porres no 4, Madrid, Spain
    Infection 37:365-7. 2009
    ..A hematogenous infection, route of bone infection with progression to dura mater and brain parenchyma was hypothesized. To our knowledge this is the first reported case of a brain abscess due to PVL-positive S. aureus...
  70. ncbi Community and nosocomial transmission of Panton-Valentine leucocidin-positive community-associated meticillin-resistant Staphylococcus aureus: implications for healthcare
    J M Orendi
    University Hospital of North Staffordshire NHS Trust, Stoke on Trent ST4 7PX, UK
    J Hosp Infect 75:258-64. 2010
    ..This is the first report of nosocomial transmission of this pandemic clone in the UK associated with a fatality. Increased vigilance in healthcare and community is needed in response to this emerging threat...
  71. ncbi Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia
    M S Morgan
    Royal Devon and Exeter Foundation Trust, Barrack Road, Exeter EX2 5DW, UK
    Int J Antimicrob Agents 30:289-96. 2007
    ..This literature review focuses on the salient features of diagnosis and management, with particular attention to the choice of antimicrobials...
  72. pmc Community associated methicillin-resistant Staphylococcus aureus, Singapore
    Li Yang Hsu
    Emerg Infect Dis 11:341-2. 2005
  73. ncbi Key adhesin gene in community-acquired methicillin-resistant Staphylococcus aureus
    Taketo Otsuka
    Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Biochem Biophys Res Commun 346:1234-44. 2006
    ..Thus, the pandemic type is characterized by the combination of luk(PV) and bbp (and cna) genes. A specific real-time PCR assay for the bbp gene was developed, and dual assay for bbp and luk(PV) in one test tube became possible...
  74. pmc Subunit composition of a bicomponent toxin: staphylococcal leukocidin forms an octameric transmembrane pore
    George Miles
    Department of Medical Biochemistry and Genetics, The Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    Protein Sci 11:894-902. 2002
    ..It is also pertinent to the mechanism of assembly of beta-PFT pores and suggests new possibilities for engineering these proteins...
  75. ncbi Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis
    Wataru Higuchi
    Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Infect Chemother 16:144-9. 2010
    ..Recently, a variety of PVL-positive MRSA clones are accumulating in Japan...
  76. ncbi Epidemiology of methicillin-resistant Staphylococcus aureus lineages in five major African towns: emergence and spread of atypical clones
    S Breurec
    Unité de Biologie Médicale et Environnementale, Institut Pasteur, 36 Avenue Pasteur, BP 220, Dakar, Senegal
    Clin Microbiol Infect 17:160-5. 2011
    ..The spread of community-associated MRSA carrying the Panton-Valentine leukocidin genes is a cause for concern, especially in Dakar and possibly throughout Africa...
  77. pmc Outbreak of skin infections in college football team members due to an unusual strain of community-acquired methicillin-susceptible Staphylococcus aureus
    Jose Mario Fontanilla
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Clin Microbiol 48:609-11. 2010
    ..We postulate that the strain is a community-associated USA300 MRSA strain that lost methicillin resistance but retained important virulence factors...
  78. pmc Molecular distinctions exist between community-associated methicillin-resistant Staphylococcus aureus colonization and disease-associated isolates in children
    Isaac Thomsen
    Department of Pediatrics, Pediatric Infectious Diseases and the Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, TN, USA
    Pediatr Infect Dis J 30:418-21. 2011
    ..To define the molecular epidemiology of colonization and disease-associated isolates of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)...
  79. ncbi Clinical isolates of Pantone-Valentine leucocidin- and gamma-haemolysin-producing Staphylococcus aureus: prevalence and association with clinical infections
    I Mesrati
    Laboratory of Research, Resistance aux Antimicrobiens, Faculty of Medicine of Tunis, Tunis, Tunisia
    J Hosp Infect 75:265-8. 2010
    ..008) and furunculosis (55.5% of strains; P = 0.036). Our findings confirmed the association between pvl-positive strains, cutaneous infections and meticillin resistance in S. aureus...
  80. ncbi Clinical and laboratory features of invasive community-onset methicillin-resistant Staphylococcus aureus infection: a prospective case-control study
    M C Wehrhahn
    Department of Microbiology and Infectious Diseases, Royal Perth Hospital and PathWest Laboratory Medicine, Western Australia, Perth, Australia
    Eur J Clin Microbiol Infect Dis 29:1025-33. 2010
    ..Invasive "PVL-positive" S. aureus infection was associated with less morbidity but similar mortality to "PVL-negative" infection...
  81. ncbi Comparison of community-associated methicillin-resistant Staphylococcus aureus from teaching hospitals in London and the USA, 2004-2006: where is USA300 in the UK?
    J A Otter
    Guy s and St Thomas Hospital and King s College London, London, UK
    Eur J Clin Microbiol Infect Dis 28:835-9. 2009
    ..There are striking differences between the molecular epidemiology of CA-MRSA in UK and US hospitals, which may have implications for control...
  82. ncbi Characteristics of patients with healthcare-associated infection due to SCCmec type IV methicillin-resistant Staphylococcus aureus
    Susan L Davis
    Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences and the School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Infect Control Hosp Epidemiol 27:1025-31. 2006
    ..The objective of the present study was to characterize the epidemiology of and clinical outcomes associated with SCCmec-IV MRSA infection acquired in the healthcare setting, compared with infection caused by MRSA of other SCCmec types...
  83. ncbi Molecular diversity within clonal complex 22 methicillin-resistant Staphylococcus aureus encoding Panton-Valentine leukocidin in England and Wales
    E Boakes
    Staphylococcus Reference Unit, Centre for Infections, Health Protection Agency, London, NW, UK
    Clin Microbiol Infect 17:140-5. 2011
    ..The observed variances in acquired elements (most notably SCCmec and PVL-encoding phages) suggested that CC22 PVL-MRSA in England and Wales have evolved on multiple occasions...
  84. pmc Complete genome sequence of Staphylococcus aureus M013, a pvl-positive, ST59-SCCmec type V strain isolated in Taiwan
    Tzu Wen Huang
    Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan
    J Bacteriol 194:1256-7. 2012
    ..Comparison of M013 with the genomes of two CA-MRSA strains in the United States revealed major differences in the regions covering several genomic islands and prophages...
  85. ncbi Community-acquired, methicillin-resistant Staphylococcus aureus isolated from children with community-onset pneumonia in China
    Wenjing Geng
    Beijing Children s Hospital Affiliated with Capital Medical University, Beijing, China
    Pediatr Pulmonol 45:387-94. 2010
    ..The results indicated that the recent CA-MRSA found in Chinese children with CAP was largely associated with the spread of the ST59-MRSA-IV clone, and most of the PVL-positive strains in this study did not cause necrotic cases...
  86. ncbi Coexistence of Panton-Valentine leukocidin-positive and -negative community-associated methicillin-resistant Staphylococcus aureus USA400 sibling strains in a large Canadian health-care region
    Kunyan Zhang
    Centre for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Calgary, Alberta, Canada
    J Infect Dis 197:195-204. 2008
    ..This study provides direct evidence that PVL genes are not necessarily the key determinants associated with the increasing dissemination of CA-MRSA strains, suggesting that the genomic milieu may play a greater role in this regard...
  87. pmc Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york
    Anna Kaltsas
    Albert Einstein College of Medicine, Department of Medicine, Infectious Disease Division, 1300 Morris Park Ave, UL 1223, Bronx, NY 10461, USA
    J Clin Microbiol 49:2992-5. 2011
    ..aureus (MRSA) and MSSA SSTIs were comparable. In multivariable analysis, the presence of lukF-PV remained a significant predictor for incision and drainage among MSSA strains...
  88. pmc Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay
    Xiao Xue Ma
    Juntendo University, Tokyo, Japan
    Emerg Infect Dis 11:973-6. 2005
    ..The clone was distinct from the highly virulent community clone represented by strain MW2, although both clones carried Panton-Valentine leukocidin gene and cna gene...
  89. pmc A postinfluenza model of Staphylococcus aureus pneumonia
    Mei Ho Lee
    Division of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Infect Dis 201:508-15. 2010
    ..Postinfluenza Staphylococcus aureus pneumonias are increasingly recognized as a major form of life-threatening infections...
  90. pmc Molecular epidemiology of Panton-Valentine leukocidin-positive Staphylococcus aureus in Spain: emergence of the USA300 clone in an autochthonous population
    Raquel Blanco
    Clinical Microbiology and Infection Control Department, Basurto Hospital, Bilbao, Spain
    J Clin Microbiol 49:433-6. 2011
    ..For the first time, the USA300 clone is reported as predominant among PVL-positive clones in a European autochthonous population, requiring active monitoring of the incidence of USA300 in Spain and throughout Europe...
  91. pmc Molecular characterization of clinical methicillin-resistant Staphylococcus aureus isolates in South Africa
    A Moodley
    Department of Veterinary Disease Biology, University of Copenhagen, Stigbøjlen 4, Frederiksberg C 1870, Copenhagen, Denmark
    J Clin Microbiol 48:4608-11. 2010
    ..Only one Panton-Valentine leukocidin-positive isolate was detected. This is the first detailed MRSA epidemiology study for the whole country...
  92. pmc contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections
    Rachel C Orscheln
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Infect Dis 49:536-42. 2009
    ..We characterize methicillin-susceptible strains that also contribute to this epidemic...
  93. pmc Molecular epidemiology of methicillin-resistant Staphylococcus aureus, rural southwestern Alaska
    Michael Z David
    Department of Pediatrics, University of Chicago, 5841 S Maryland Ave, MC 6054, Chicago, IL 60637, USA
    Emerg Infect Dis 14:1693-9. 2008
    ..1% were ST8. Among 120 prospective isolates, 57.5% were clindamycin resistant. CA-MRSA epidemiology in southwestern Alaska differs from that in the lower 48 states; ST8 strains were rarely identified and clindamycin resistance was common...
  94. ncbi Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin
    Isamu Hongo
    Department of Infection Control Science, Graduate School of Medicine, Juntendo University, Tokyo, Japan
    J Infect Dis 200:715-23. 2009
    ..Phenol-soluble modulin alpha 3 did, however, enhance PVL-mediated lysis of human PMNs...
  95. ncbi Molecular characterization and susceptibility of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from hospitals and the community in Vladivostok, Russia
    T Baranovich
    Department of Infectious Disease Control and International Medicine, Division of Public Health, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Microbiol Infect 16:575-82. 2010
    ..Additionally, the emergence of PVL-positive MSSA strains with enhanced virulence was observed, warranting continued surveillance...
  96. ncbi Community-acquired methicillin-resistant Staphylococcus aureus: what do we need to know?
    W Witte
    National Reference Centre for Staphylococci, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany
    Clin Microbiol Infect 15:17-25. 2009
    ..So far, CA-MRSA infections seem to be much less frequent in Europe than in the USA, where patients with particular predispositions and low social status are at especial risk...
  97. ncbi Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, USA
    J Infect Dis 193:1495-503. 2006
    ..The extent to which the horizontal transfer of virulence genes has contributed to the emergence of contemporary virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) in hospital and community settings is poorly understood...
  98. ncbi Effect of antibiotics, alone and in combination, on Panton-Valentine leukocidin production by a Staphylococcus aureus reference strain
    O Dumitrescu
    INSERM U851 and Université Lyon 1, Centre National de Référence des Staphylocoques, Faculte Laennec, Lyon, France
    Clin Microbiol Infect 14:384-8. 2008
    ..These data support the use of oxacillin in combination with clindamycin, rifampicin or linezolid for the treatment of PVL-positive S. aureus infections...
  99. pmc Methicillin-resistant Staphylococcus aureus clones, Western Australia
    Geoffrey W Coombs
    Royal Perth Hospital, Perth, Western Australia, Australia
    Emerg Infect Dis 12:241-7. 2006
    ..The emergence of multidrug-resistant CA-MRSA clones and the detection of PVL toxin genes in clones previously reported as PVL negative is a major public health concern...
  100. ncbi Healthcare-associated outbreaks and community-acquired infections due to MRSA carrying the Panton-Valentine leucocidin gene in southeastern Germany
    H Linde
    Institut fur Medizinische Mikrobiologie und Hygiene, Franz Josef Strauss Allee 11, 93049 Regensburg, Germany
    Eur J Clin Microbiol Infect Dis 24:419-22. 2005
    ..The findings represent the largest number of PVL-MRSA cases detected in Germany so far, and demonstrate the potential of this emerging pathogen to spread within the community and in healthcare institutions...
  101. ncbi Transcription of the phage-encoded Panton-Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background
    Christiane Wirtz
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    Microbiology 155:3491-9. 2009
    ..These results suggest a fine tuning between certain phages and their host, with major impact on the expression of phage-encoded virulence genes...

Research Grants19

  1. Pathogensis of Bacterial corneal infection
    Gerald B Pier; Fiscal Year: 2013
    ..These studies should also be informative about the general role leukocidins have in the pathogenesis of S. aureus corneal infections...
  2. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..
  3. Multi-specific Antibody Therapy by targeting S. aureus toxins and polysaccharides
    M Javad Aman; Fiscal Year: 2013
    ....
  4. Type I interferon-induced protection from staphylococcal pore-forming toxins
    TIMUR OLEGOVICH YAROVINSKY; Fiscal Year: 2010
    ..aureus. We propose to evaluate whether interferon-induced protection from alpha-toxin benefits the host and has a therapeutic potential for treatment of staphylococcal infections. ..
  5. Mechanisms of PVL-induced Acute Lung Injury
    Binh An Diep; Fiscal Year: 2013
    ..Our proposed experiments will increase knowledge of the role of PVL and related toxins in pathogenesis of lung injury and establish a basis for the development of new therapeutic approaches. ..
  6. Spread of Community-Acquired MRSA Among Household Contacts
    Robert S Daum; Fiscal Year: 2010
    ....
  7. Functional Analysis of Staphylococcus aureus LukAB Cytotoxin.
    Victor J Torres; Fiscal Year: 2011
    ..abstract_text> ..
  8. STRUCTURE AND FUNCTION OF S AUREUS ALPHA HEMOLYSIN
    JAMES GOUAUX; Fiscal Year: 2002
    ..The kinetics of assembly under conditions similar to those under which the toxins were crystallized will be determined for the purpose of structure/function correlation. ..
  9. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  10. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  11. Small molecule inhibitors of bacterial secretion system
    Vincent Lee; Fiscal Year: 2008
    ..abstract_text> ..
  12. CARDIOTOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 2006
    ....
  13. Host genes required for P. aeruginosa pathogenesis
    Vincent Lee; Fiscal Year: 2004
    ..abstract_text> ..
  14. The Role of Wolbachia Endobacteria in River Blindness
    Eric Pearlman; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  15. MOLECULAR ANALYSIS OF STAPHYLOCOCCAL EXFOLIATIVE TOXIN A
    LISA PLANO; Fiscal Year: 2007
    ..We further propose to develop an animal model of staphylococcal impetigo to address the role of the exfoliative toxins in pathogenesis of these bacteria. ..
  16. Device use in Nursing Homes: Reducing Risk of Infection
    Lona Mody; Fiscal Year: 2007
    ..abstract_text> ..
  17. Social Networks of S. aureus Carriage Among Drug Users
    FRANKLIN LOWY; Fiscal Year: 2006
    ..Miller's preexistent cohort of women drug users and their network members in the Bedford Stuyvesant section of Brooklyn. This will allow for the rapid integration of this investigation into her ongoing study. ..
  18. S AUREUS PATHOGENESIS IN HIV INFECTION AND IN DRUG USE
    FRANKLIN LOWY; Fiscal Year: 2002
    ..The ability to integrate both epidemiologic and biologic studies using a well defined high risk cohort of drug users and HIV-infected subjects provides an ideal setting to examine these issues. ..
  19. STAPHYLOCOCCAL COLONIZATION AND DISEASES IN DRUG USERS
    FRANKLIN LOWY; Fiscal Year: 2002
    ..In order to develop these alternatives, we must first understand the strain and host determinants that play a role in this process. ..