antineutrophil cytoplasmic antibodies

Summary

Summary: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for WEGENER'S GRANULOMATOSIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.

Top Publications

  1. pmc Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall
    J Hermann
    Medical University, Graz, Department of Internal Medicine, Division of Rheumatology, Auenbruggerplatz 15, A 8036 Graz, Austria
    Ann Rheum Dis 64:641-3. 2005
  2. ncbi Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    Stephan R Targan
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
    Gastroenterology 128:2020-8. 2005
  3. ncbi Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome
    Renato A Sinico
    Dipartimento di Nefrologia e Immunologia, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy
    Arthritis Rheum 52:2926-35. 2005
  4. ncbi Addendum to the International Consensus Statement on testing and reporting of antineutrophil cytoplasmic antibodies. Quality control guidelines, comments, and recommendations for testing in other autoimmune diseases
    Judy Savige
    University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, VIC 3084, Australia
    Am J Clin Pathol 120:312-8. 2003
  5. pmc The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina, 303 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 167:39-45. 2005
  6. pmc Pulmonary vasculitis
    Kevin K Brown
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:48-57. 2006
  7. pmc Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease
    E Israeli
    Gastroenterology Unit, Department of Medicine, Hebrew University Hadassah Medical Center, POB 12000, Jerusalem, 91120, Israel
    Gut 54:1232-6. 2005
  8. ncbi Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis
    Philip J Klemmer
    Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill 27599 7155, USA
    Am J Kidney Dis 42:1149-53. 2003
  9. ncbi Antineutrophil cytoplasmic antibodies
    Xavier Bosch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Lancet 368:404-18. 2006
  10. ncbi The antineutrophil cytoplasmic antibody-associated vasculitides
    Philip Seo
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 117:39-50. 2004

Detail Information

Publications228 found, 100 shown here

  1. pmc Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall
    J Hermann
    Medical University, Graz, Department of Internal Medicine, Division of Rheumatology, Auenbruggerplatz 15, A 8036 Graz, Austria
    Ann Rheum Dis 64:641-3. 2005
    ..While antibodies directed against proteinase 3 (PR3-ANCA) and myeloperoxidase (MPO-ANCA) have a high specificity for the diagnosis of systemic vasculitis, they may also be found as an epiphenomenon of acute viral infection...
  2. ncbi Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    Stephan R Targan
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
    Gastroenterology 128:2020-8. 2005
    ....
  3. ncbi Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome
    Renato A Sinico
    Dipartimento di Nefrologia e Immunologia, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy
    Arthritis Rheum 52:2926-35. 2005
    ..However, while antineutrophil cytoplasmic antibodies (ANCAs) are consistently found in 75-95% of patients with Wegener's granulomatosis or microscopic ..
  4. ncbi Addendum to the International Consensus Statement on testing and reporting of antineutrophil cytoplasmic antibodies. Quality control guidelines, comments, and recommendations for testing in other autoimmune diseases
    Judy Savige
    University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, VIC 3084, Australia
    Am J Clin Pathol 120:312-8. 2003
    ....
  5. pmc The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina, 303 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 167:39-45. 2005
    ..This raises the possibility that therapeutic strategies to reduce circulating neutrophils could be beneficial to patients with ANCA-induced NCGN...
  6. pmc Pulmonary vasculitis
    Kevin K Brown
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:48-57. 2006
    ..In this article, we focus on the more common, antineutrophil cytoplasmic antibody-associated disorder, vasculitides...
  7. pmc Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease
    E Israeli
    Gastroenterology Unit, Department of Medicine, Hebrew University Hadassah Medical Center, POB 12000, Jerusalem, 91120, Israel
    Gut 54:1232-6. 2005
    ..Familial clustering of these antibodies has been described, suggesting they might be genetic markers. Our aim was to investigate the presence of these antibodies before the emergence of overt clinical manifestations...
  8. ncbi Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis
    Philip J Klemmer
    Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill 27599 7155, USA
    Am J Kidney Dis 42:1149-53. 2003
    ..Unlike Goodpasture's syndrome with diffuse alveolar hemorrhage (DAH), there are few studies examining therapy for patients with DAH associated with antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitis (SVV)...
  9. ncbi Antineutrophil cytoplasmic antibodies
    Xavier Bosch
    Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Lancet 368:404-18. 2006
    ..lupus erythematosus or antiglomerular basement membrane antibodies in Goodpasture's syndrome), antineutrophil cytoplasmic antibodies (ANCA) have provided doctors with a useful serological test to assist in diagnosis of small-vessel ..
  10. ncbi The antineutrophil cytoplasmic antibody-associated vasculitides
    Philip Seo
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 117:39-50. 2004
    ..are small- to medium-vessel vasculitides linked by overlapping pathology and the presence of antineutrophil cytoplasmic antibodies (ANCA)...
  11. ncbi Use of extracorporeal membrane oxygenation in a patient with diffuse alveolar hemorrhage
    S Hinan Ahmed
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 126:305-9. 2004
    ..We report the successful use of ECMO in an adult patient with severe hypoxemic respiratory failure secondary to diffuse alveolar hemorrhage from Wegener granulomatosis...
  12. ncbi Antineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus: prevalence, antigen specificity, and clinical associations
    I Manolova
    Laboratory of Clinical Immunology, University Hospital, Faculty of Medicine, Thracian University, Stara Zagora, Bulgaria
    Rheumatol Int 20:197-204. 2001
    Fifty-five patients with systemic lupus erythematosus (SLE) were examined for antineutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IIF)...
  13. ncbi Antineutrophil cytoplasmic antibodies induce human monocytes to produce oxygen radicals in vitro
    S Weidner
    , Germany
    Arthritis Rheum 44:1698-706. 2001
    OBJECTIVE: Antineutrophil cytoplasmic antibodies (ANCA) are believed to play a pathogenetic role in necrotizing small-vessel vasculitis...
  14. ncbi Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome
    Régis Sablé-Fourtassou
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
    Ann Intern Med 143:632-8. 2005
    Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied.
  15. ncbi Antineutrophil cytoplasmic antibodies and associated diseases: a review of the clinical and laboratory features
    J Savige
    Department of Medicine, University of Melbourne, Austin, Australia
    Kidney Int 57:846-62. 2000
    ..First, the "International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA)" has been developed to optimize ANCA testing...
  16. ncbi A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis
    E Csernok
    Department of Rheumatology, University of Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Rheumatology (Oxford) 41:1313-7. 2002
    ..performance of 11 commercial enzyme-linked immunosorbent assay (ELISA) kits for the detection of antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) and myeloperoxidase (MPO) in patients with Wegener's ..
  17. ncbi Clinical outcome of patients with coexistent antineutrophil cytoplasmic antibodies and antibodies against glomerular basement membrane
    Jelka Lindic
    Department of Nephrology, University Medical Center Ljubljana, SI 1000 Ljubljana, Slovenia
    Ther Apher Dial 13:278-81. 2009
    b>Antineutrophil cytoplasmic antibodies (ANCA) and antibodies against glomerular basement membrane (anti-GBM) rarely coexist. Both antibodies may be associated with rapidly progressive glomerulonephritis and pulmonary hemorrhage...
  18. ncbi Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge
    Branka Bonaci-Nikolic
    Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Belgrade, Serbia
    Clin Rheumatol 29:893-904. 2010
    ..The serological profile should be repeated after specific antimicrobial or surgical therapy, since some cases might require IST...
  19. ncbi Pulmonary renal syndrome: a 4-year, single-center experience
    Hugh Gallagher
    SW Thames Renal Unit, St Helier Hospital, Carshalton, Surrey, UK
    Am J Kidney Dis 39:42-7. 2002
    ..Cyclophosphamide-associated neutropenia and infection were frequent contributors to death, and less toxic alternatives may improve outcome in PRS...
  20. ncbi Analysis of intractable factors in chronic airway infections: role of the autoimmunity induced by BPI-ANCA
    S Ohtami
    First Department of Internal Medicine, Kyorin University, School of Medicine, 6 20 2 Sinkawa, Mitaka, Tokyo 181 8611, Japan
    J Infect Chemother 7:228-38. 2001
    ....
  21. pmc Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 110:955-63. 2002
    ..This animal model offers strong support for a direct pathogenic role for ANCA IgG in human glomerulonephritis and vasculitis...
  22. ncbi Comparison of anti-PR3 capture and anti-PR3 direct ELISA for detection of antineutrophil cytoplasmic antibodies (ANCA) in long-term clinical follow-up of PR3-ANCA-associated vasculitis patients
    O Arranz
    Nephrology Service, Hospital Clinic, Instituto de Investigaciones Biomédicas IDIBAPS, Universidad de Barcelona, Spain
    Clin Nephrol 56:295-301. 2001
    ..Our results indicate that the new capture ELISA test is more effective than direct ELISA in the follow-up of patients with PR3-ANCA-associated vasculitis and in the detection of relapses...
  23. pmc The binding of proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) varies in different ELISAs
    M Trevisin
    Immunology Unit, Division of Laboratory Medicine, Austin Hospital, Heidelberg, Victoria 3084, Australia
    J Clin Pathol 57:303-8. 2004
    The demonstration of proteinase 3 specific antineutrophil cytoplasmic antibodies (PR3-ANCA), and the estimation of antibody values are useful in the diagnosis and management of patients with Wegener's granulomatosis (WG)...
  24. ncbi ANCA-positive vasculitis
    Lavanya Kamesh
    Renal Immunobiology, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham B15 277, UK
    J Am Soc Nephrol 13:1953-60. 2002
  25. ncbi Diagnostic role of anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic antibodies in patients with inflammatory bowel disease
    Byeong Gwan Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Dis Colon Rectum 45:1062-9. 2002
    ....
  26. ncbi Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    William S Mow
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gastroenterology 126:414-24. 2004
    ..Our aim was to determine whether expression of antibodies against Crohn's disease-related bacterial sequence and Escherichia coli outer membrane porin C is associated with distinct phenotypic manifestations...
  27. pmc Immunofluorescent patterns produced by antineutrophil cytoplasmic antibodies (ANCA) vary depending on neutrophil substrate and conjugate
    W Pollock
    The University Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, VIC 3084, Australia
    J Clin Pathol 55:680-3. 2002
    The "International consensus statement on testing and reporting antineutrophil cytoplasmic antibodies (ANCA)" advocates screening by indirect immunofluorescence (IIF), but external quality assessment programmes often demonstrate ..
  28. pmc Autoantibodies in vasculitis
    Allan Wiik
    Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
    Arthritis Res Ther 5:147-52. 2003
    ..Since that time, antineutrophil cytoplasmic antibodies (ANCAs) directed at the azurophilic granule proteins proteinase-3 and myeloperoxidase have been ..
  29. ncbi Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn's disease
    Frank H Klebl
    Department of Internal Medicine I, dagger Institute of Pathology, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 9:302-7. 2003
    ..AIM The aim of this study was to test whether perinuclear antineutrophil cytoplasmic antibodies (pANCAs) or anti-Saccharomyces cerevisiae antibodies (ASCAs) correlate to subtypes of CD according ..
  30. pmc Detection rate and antigenic specificities of antineutrophil cytoplasmic antibodies in chinese patients with clinically suspected vasculitis
    Gang Xin
    Department of Nephrology, Peking University First Hospital, Beijing 100034, People s Republic of China
    Clin Diagn Lab Immunol 11:559-62. 2004
    The detection rate of antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with clinically suspected small vessel vasculitis was investigated, and their antigen specificity and demographic features were analyzed...
  31. ncbi Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease
    Carolina Mancho
    Department of Animal Medicine and Surgery, College of Veterinary Medicine, Complutense University of Madrid, Av Puerta de Hierro s n, 28040 Madrid, Spain
    J Vet Diagn Invest 22:553-8. 2010
    ....
  32. pmc Evaluation of the combined application of ethanol-fixed and formaldehyde-fixed neutrophil substrates for identifying atypical perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease
    Maria Papp
    2nd Department of Medicine, University of Debrecen, Hungary
    Clin Vaccine Immunol 16:464-70. 2009
    No clear guidelines for indirect immunofluorescence (IIF) detection and interpretation of antineutrophil cytoplasmic antibodies (ANCA) have been proposed for inflammatory bowel diseases (IBD)...
  33. ncbi Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study
    C J Ooi
    Department of Gastroenterology, Singapore General Hospital, 1 Hospital Drive, Singapore 169608
    Ann Acad Med Singapore 29:704-7. 2000
    The pathogenic importance of antineutrophil cytoplasmic antibodies (ANCAs) in inflammatory bowel disease (IBD) is unclear and target antigen localisation studies may lend insight to the specific pathogenic mechanisms of IBD...
  34. ncbi Methimazole-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and lupus-like syndrome with a cutaneous feature of vesiculo-bullous systemic lupus erythematosus
    Haw Yueh Thong
    Acta Derm Venereol 82:206-8. 2002
  35. ncbi Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies
    J Charles Jennette
    Department of Pathology and Laboratory Medicine, 303 Brinkhous Bullitt Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 17:1235-42. 2006
    ..The pathogenesis of ANCA disease is multifactorial, with genetic and environmental factors influencing onset of the autoimmune response, the mediation of acute injury, and the induction of the chronic response to injury...
  36. ncbi Antineutrophil cytoplasmic antibodies in T-cell receptor alpha-deficient mice with chronic colitis
    E Mizoguchi
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Gastroenterology 113:1828-35. 1997
    b>Antineutrophil cytoplasmic antibodies (ANCAs) have been detected in approximately 60% of sera from patients with ulcerative colitis...
  37. ncbi Update in the diagnosis and management of pulmonary vasculitis
    Stephen K Frankel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:452-65. 2006
    ..However, for the purpose of this review, we will focus on the ANCA-associated vasculitides...
  38. ncbi Sino-nasal bony and cartilaginous destruction associated with cocaine abuse, S. aureus and antineutrophil cytoplasmic antibodies
    S Simsek
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Neth J Med 64:248-51. 2006
    ..Two of the patients also had a perforation of the hard palate. In all four, antineutrophil cytoplasmic antibodies (ANCA) were found...
  39. pmc ELISA is the superior method for detecting antineutrophil cytoplasmic antibodies in the diagnosis of systemic necrotising vasculitis
    A Harris
    Institute of Medical and Veterinary Science, Adelaide, South Australia
    J Clin Pathol 52:670-6. 1999
    b>Antineutrophil cytoplasmic antibodies (ANCA) have been used as a diagnostic marker for systemic necrotising vasculitis, a disease classification which includes Wegener granulomatosis, microscopic and classic polyarteritis nodosa, and ..
  40. ncbi Relative importance of CCR5 and antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis
    Yihua Zhou
    Department of Rheumatic and Immunologic Diseases, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Rheumatol 30:1541-7. 2003
    ....
  41. ncbi Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature
    Julio A Chirinos
    Department of Medicine, University of Miami, School of Medicine and Veterans Affairs Medical Center, Miami, FL, USA
    Clin Rheumatol 26:590-5. 2007
    ..In this paper, we review reported cases of ANCA-positive bacterial endocarditis and compare them to the reported cases of ANCA-associated idiopathic vasculitis with endocardial compromise...
  42. ncbi Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis
    Floriana Lurati-Ruiz
    Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Rheumatol 32:2167-72. 2005
    The predictive value of antineutrophil cytoplasmic antibodies (ANCA) as markers of clinical activity of small vessel vasculitis is controversial...
  43. pmc Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides
    Branka Bonaci-Nikolic
    Institute of Allergy and Clinical Immunology, Clinical Centre of Serbia, Belgrade, Serbia and Montenegro
    Arthritis Res Ther 7:R1072-81. 2005
    ..Different serological profiles could help in the differential diagnosis and adequate therapeutic approach to ANCA-positive ATD-treated patients with symptoms of systemic disease...
  44. ncbi Sequential development of perinuclear ANCA-associated vasculitis and anti-glomerular basement membrane glomerulonephritis
    Jacques Serratrice
    Service de Médecine Interne and Service d Anatomie Pathologique, CHU Timone, Marseille, France
    Am J Kidney Dis 43:e26-30. 2004
    ..In our case, ANCAs were supposed to be of pathogenic importance because they may have uncovered the Goodpasture antigen. This case report lends further support to the concept that p-ANCA vasculitis may trigger anti-GBM disease...
  45. pmc Differentiation of antineutrophil nuclear antibodies in inflammatory bowel and autoimmune liver diseases from antineutrophil cytoplasmic antibodies (p-ANCA) using immunofluorescence microscopy
    B Terjung
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Clin Exp Immunol 126:37-46. 2001
    Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) directed against cytoplasmic proteins of neutrophils have been studied extensively in patients with systemic vasculitides...
  46. ncbi Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on antimyeloperoxidase antibodies
    H K Choi
    Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Rheumatol 28:1584-90. 2001
    ..To summarize the pertinent data, we conducted a metaanalysis examining the diagnostic value of ANCA testing systems that include assays for anti-MPO...
  47. ncbi Crescentic glomerulonephritis accompanied by myeloperoxidase-antineutrophil cytoplasmic antibodies in a patient having myelodysplastic syndrome with trisomy 7
    A Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, Hondo, Japan
    Am J Kidney Dis 31:336-40. 1998
    ..This is the first case of MPO-ANCA-related crescentic glomerulonephritis in a patient with myelodysplastic syndromes (MDS). A possible relationship between MPO-ANCA and MDS is discussed...
  48. ncbi Rats injected with syngenic rat apoptotic neutrophils develop antineutrophil cytoplasmic antibodies
    Y C Patry
    Department of Immunology, , Nantes University Hospital, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 1, France
    J Am Soc Nephrol 12:1764-8. 2001
    b>Antineutrophil cytoplasmic antibodies (ANCA) are present in sera from patients with various forms of vasculitis-associated glomerulonephritis...
  49. pmc Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils
    J J Yang
    Departments of Medicine and Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
    Clin Exp Immunol 121:165-72. 2000
    ..Previously published observations indicate that the interaction of ANCA with primed neutrophils results in neutrophil activation, which may be involved in the pathogenesis of ANCA vasculitis...
  50. ncbi Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils
    Ralph Kettritz
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltbergstrasse 50, 13122 Berlin, Germany
    J Am Soc Nephrol 13:1740-9. 2002
    b>Antineutrophil cytoplasmic antibodies (ANCA) activate human polymorphonuclear neutrophils (PMN) primed with tumor necrosis factor alpha (TNF-alpha) in vitro...
  51. ncbi Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies in the diagnosis and monitoring of systemic vasculitides
    David Sinclair
    Department of Clinical Biochemistry, Wessex Renal and Transplant Service, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 44:432-42. 2007
    ....
  52. ncbi Induction of biologically active antineutrophil cytoplasmic antibodies by immunization with human apoptotic polymorphonuclear leukocytes
    Lubica Rauova
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Clin Immunol 103:69-78. 2002
    ..or apoptosis of polymorphonuclear leukocytes (PMN) is an important mechanism for interaction of antineutrophil cytoplasmic antibodies (ANCA) with these antigens...
  53. ncbi Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens
    Carol J Landers
    Cedars Sinai Medical Center Inflammatory Bowel Disease Center, Los Angeles, California, USA
    Gastroenterology 123:689-99. 2002
    ..fluorescens-associated sequence I2, antisaccharomyces cerevisiae antibody (ASCA), and perinuclear antineutrophil cytoplasmic antibodies). Our aim was to determine whether there are heterogeneous responses to these specific antigens.
  54. ncbi Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo
    Heiko Pfister
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Blood 104:1411-8. 2004
    ..In conclusion, our in vivo study provides the first evidence for a pathogenic effect of proteinase 3-specific ANCAs at local sites of inflammation...
  55. ncbi [Antineutrophil cytoplasmic antibodies]
    G D Sebastiani
    U O C di Reumatologia, Azienda Ospedaliera San Camillo Forlanini, Roma, Italia
    Reumatismo 61:69-76. 2009
    b>Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes lysosomes...
  56. ncbi Nine patients with anti-neutrophil cytoplasmic antibody-positive vasculitis successfully treated with rituximab
    P Eriksson
    Department of Rheumatology, University Hospital, Linkoping, Sweden
    J Intern Med 257:540-8. 2005
    ..RIT is used for treatment of B-cell lymphomas, but has also shown beneficial effects in autoimmune diseases. In this case series RIT was used in anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis...
  57. pmc Poor predictive value of antinucleosome and antineutrophil cytoplasmic antibodies in a 270 inception cohort of patients with early naked arthritis of less than one year's duration
    J M Berthelot
    Ann Rheum Dis 61:760-1. 2002
  58. ncbi Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins
    Sumiaki Tanaka
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 171:6090-6. 2003
    ..The greater activity of the FcgammaRIIIB-NA1 genotype may also explain the greater severity of disease and its flare-ups in patients with this allele...
  59. ncbi Pulmonary-renal syndrome in a newborn with placental transmission of ANCAs
    David J Schlieben
    Department of Medicine, Section of Nephrology, Rush University Medical Center, Chicago, IL, USA
    Am J Kidney Dis 45:758-61. 2005
    Despite clinical and experimental data suggesting a direct relationship between antineutrophil cytoplasmic antibodies (ANCAs) and disease activity in patients with microscopic polyangiitis (MPA), the causal relationship between ..
  60. ncbi Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease
    Zsolt Barta
    3rd Dept of Medicine, University of Debrecen, Moricz Zs Krt 22 4004 Debrecen, Hungary
    World J Gastroenterol 9:2308-12. 2003
    ..To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease...
  61. ncbi The spectrum of Wegener's granulomatosis and disease relapse
    Paul A Bacon
    University of Birmingham, Birmingham, United Kingdom
    N Engl J Med 352:330-2. 2005
  62. ncbi A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies
    David Jayne
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 349:36-44. 2003
    ..We investigated whether exposure to cyclophosphamide in patients with generalized vasculitis could be reduced by substitution of azathioprine at remission...
  63. ncbi Clinical applications of antineutrophil cytoplasmic antibody testing
    Wilhelm H Schmitt
    Vth Medical Clinic Nephrology, Endocrinolgy, Rheumatolgy, University Clinic Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Mannheim, Germany
    Curr Opin Rheumatol 16:9-17. 2004
    b>Antineutrophil cytoplasmic antibodies are closely associated with Wegener granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome and have contributed to new pathogenetic concepts and improved nomenclature of systemic ..
  64. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
    b>Antineutrophil cytoplasmic antibodies (ANCA) may be important in the pathophysiology of necrotizing vasculitis. ANCA activate human neutrophils primed with tumor necrosis factor-alpha (TNF-alpha) in vitro...
  65. pmc Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis
    W Y Tse
    Department of Nephrology, Queen Elizabeth Hospital, and Department of Immunology, The Medical School, Birmingham University, Birmingham, UK
    Clin Exp Immunol 119:574-7. 2000
    ..The over-representation of the FcgammaRIIIb homozygous NA1 allele in patients with anti-MPO antibodies may have implications for disease susceptibility...
  66. ncbi Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab
    R Stasi
    Department of Medical Sciences, Regina Apostolorum Hospital, Via San Francesco, 50, 00041 Albano Laziale, Italy
    Rheumatology (Oxford) 45:1432-6. 2006
    ..We prospectively studied the long-term effects of rituximab in 10 patients with anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis refractory to conventional therapy (n=3) or in second or subsequent relapse (n=7)...
  67. ncbi Prevalence of positive anti-neutrophil cytoplasmic antibody (ANCA) in patients receiving anti-thyroid medication
    J E Gunton
    Department of Endocrinology, Royal North Shore Hospital, St Leonards, Sydney, Australia
    Eur J Endocrinol 142:587. 2000
    ....
  68. ncbi Clinical evaluation of a capture ELISA for detection of proteinase-3 antineutrophil cytoplasmic antibody
    K W Westman
    Department of Nephrology, Lund University, Sweden
    Kidney Int 53:1230-6. 1998
    Detection of antineutrophil cytoplasmic antibodies (ANCA) has become a useful tool in the diagnosis of Wegener's granulomatosis and microscopic polyangiitis...
  69. pmc IgA class antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and autoimmune hepatitis
    C Schwarze
    Department of Internal Medicine I, University of Bonn, Germany
    Clin Exp Immunol 133:283-9. 2003
    b>Antineutrophil cytoplasmic antibodies (ANCA) of IgG class have been described at high prevalence in autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). Data on IgA class ANCA in these diseases are limited...
  70. ncbi Pathogenesis of PR3-ANCA associated vasculitis
    C G M Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Autoimmun 30:29-36. 2008
    ..These factors, together, may explain, at least in part, differences in clinical expression between MPO-ANCA and PR3-ANCA associated vasculitis...
  71. ncbi Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists
    Karina A Keogh
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Med 115:284-90. 2003
    To determine the association of antineutrophil cytoplasmic antibodies (ANCA) and leukotriene receptor antagonists with disease activity in a large series of patients with Churg-Strauss syndrome.
  72. pmc Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake
    Lisa C Willcocks
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY, England, UK
    J Exp Med 205:1573-82. 2008
    ..This is the first report of an association between disease-related gene CNV and variation in protein expression and function that may contribute to autoimmune disease susceptibility...
  73. ncbi Antiproteinase 3- and antimyeloperoxidase-associated vasculitis
    C F Franssen
    Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands
    Kidney Int 57:2195-206. 2000
    ..Likewise, in the presence of vasculitis, the terms "anti-PR3-associated vasculitis" and "anti-MPO-associated vasculitis" are useful concepts...
  74. ncbi Anti-Saccharomyces cerevisiae mannan antibodies and antineutrophil cytoplasmic autoantibodies in Greek patients with inflammatory bowel disease
    I E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Crete, Greece
    Am J Gastroenterol 96:449-54. 2001
    ..Measurement of pANCA and ASCA together has a rather limited value in the differential diagnosis between UC and CD but may be of help in studying disease heterogeneity...
  75. ncbi Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India
    U Shankarkumar
    Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
    J Autoimmun 24:227-33. 2005
    ....
  76. ncbi Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study
    Anthony D Booth
    Department of Medicine, Addenbrookes s Hospital, Cambs, UK
    Am J Kidney Dis 41:776-84. 2003
    ..Renal involvement is frequently present in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis and is an important cause of end-stage renal failure (ESRF)...
  77. ncbi [Wegener's granulomatosis]
    Christian Pagnoux
    Service de Medecine Interne, Centre de référence national maladies rares, vascularites nécrosantes et sclérodermies, Hopital Cochin, AP HP, université Paris V René Descartes, Paris, France
    Presse Med 36:860-74. 2007
    ..Today, however, they are reserved for refractory cases...
  78. ncbi Antineutrophil cytoplasmic antibodies of IgA class in neutrophilic dermatoses with emphasis on erythema elevatum diutinum
    Nakhle Ayoub
    Dermatology Internal Medicine Department, Pitie Salpetriere Hospital, Paris, France
    Arch Dermatol 140:931-6. 2004
    To evaluate the prevalence of IgA and IgG antineutrophil cytoplasmic antibodies (ANCAs) in erythema elevatum diutinum in comparison with 2 other groups of neutrophilic dermatoses: Sweet syndrome and pyoderma gangrenosum.
  79. ncbi Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study
    Elena Csernok
    Department of Rheumatology, University of Schleswig Holstein Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Rheumatology (Oxford) 43:174-80. 2004
    ..To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories...
  80. ncbi Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFalpha-dependent and Fc-receptor-independent way
    Sven Jarius
    Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
    Blood 109:4376-82. 2007
    ....
  81. ncbi Disease spectrum of patients with antineutrophil cytoplasmic autoantibodies of defined specificity: distinct differences between patients with anti-proteinase 3 and anti-myeloperoxidase autoantibodies
    C Franssen
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    J Intern Med 244:209-16. 1998
    ..To compare the disease spectrum of consecutive patients with antineutrophil cytoplasmic autoantibodies directed against proteinase 3 (anti-PR3) or myeloperoxidase (anti-MPO)...
  82. ncbi Antineutrophil cytoplasmic antibodies, anti-Saccharomyces cerevisiae antibodies, and specific IgE to food allergens in children with inflammatory bowel diseases
    J Bartunkova
    Institute of Immunology, Second Medical Faculty, Charles University, University Hospital Motol, Prague, Czech Republic
    Clin Immunol 102:162-8. 2002
    ..Monitoring of ANCA, its specificity, and titer determination does not bring more information. Testing for specific IgE to food allergens may be considered in individual patients...
  83. ncbi Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction
    Dimitrios Vassilopoulos
    The Henry Dunant Hospital, Athens, Greece
    Arthritis Rheum 49:151-5. 2003
    To determine the prevalence of antineutrophil cytoplasmic antibodies (ANCA) in patients with diseases that may mimic systemic vasculitides, such as severe multiorgan dysfunction (MOD) and parenchymal pulmonary disorders.
  84. ncbi Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis
    Elena Csernok
    University of Lubeck, Department of Rheumatology, Vasculitis Center UKSH and Clinical Center Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Curr Opin Rheumatol 22:43-8. 2010
    Drugs and infections may induce antineutrophil cytoplasmic antibodies (ANCA) and vasculitic manifestations mimicking ANCA-associated vasculitides (AAV) and mechanisms relevant in their pathogenesis...
  85. pmc Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides
    P Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, 23538 Luebeck, Germany
    Clin Exp Immunol 141:201-10. 2005
    ..Alteration of the T-cell response and anomalous autoantigen-presentation in lymphoid-structures could facilitate development of autoimmune disease in ANCA-associated vasculitides...
  86. ncbi Prevalence of antineutrophil cytoplasmic autoantibodies in patients with tuberculosis
    L F Flores-Suarez
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
    Rheumatology (Oxford) 42:223-9. 2003
    ..To determine the prevalence of antineutrophil cytoplasmic autoantibodies (ANCA) in sera of patients with tuberculosis compared with healthy control subjects and a group of patients with atopic asthma...
  87. pmc Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?
    Sophie Ohlsson
    Department of Nephrology, Lund University, Sweden
    Mediators Inflamm 13:275-83. 2004
    ..Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value...
  88. ncbi The prevalence and target antigens of antithyroid drugs induced antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with hyperthyroidism
    Ying Gao
    Department of Nephrology, Peking University First Hospital, Beijing, PR China
    Endocr Res 30:205-13. 2004
    ..The current cross-sectional study aimed to investigate the prevalence and the target antigens of ANCA in Chinese patients with hyperthyroidism pre- and post-antithyroid medication therapy...
  89. ncbi Daily oral versus pulse intravenous cyclophosphamide in the therapy of ANCA-associated vasculitis--preliminary single center experience
    Z Rihova
    First Department of Medicine, U nemocnice 2, 128 08 Praha 2, Czech Republic
    Prague Med Rep 105:64-8. 2004
    ..of induction of remission in patients with generalized, but not immediately life-threatening ANCA (antineutrophil cytoplasmic antibodies) -associated vasculitis...
  90. ncbi Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo
    Mark A Little
    The Eric Bywaters Centre for Vascular Inflammation, London, United Kingdom
    Blood 106:2050-8. 2005
    ....
  91. ncbi Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: increased prevalence of ASCA and pANCA
    H P Török
    Medizinische Poliklinik, Ludwig Maximilians Universitat, Munchen, Germany
    Digestion 70:49-54. 2004
    ..g. antibodies against Saccharomyces cerevisiae (ASCA), antibodies against exocrine pancreas (PAB) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) are present in HLA-B27-associated SpA.
  92. ncbi Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases
    Marc Feldmann
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Campus, London, UK
    J Am Soc Nephrol 17:1243-52. 2006
    ..Therefore, there is a need for further evaluation of the use of anti-TNF antibodies in patients with ANCA-associated glomerulonephritis...
  93. ncbi Renal vasculitis--an update in 2004
    Anthony D Booth
    Nephrol Dial Transplant 19:1964-8. 2004
  94. pmc Plasma levels of soluble interleukin 2 receptor, soluble CD30, interleukin 10 and B cell activator of the tumour necrosis factor family during follow-up in vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies: associations with di
    J S F Sanders
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 GZ Groningen, The Netherlands
    Ann Rheum Dis 65:1484-9. 2006
    ..follow-up, is predictive for persistent or renewed antineutrophil cytoplasmic antibody (ANCA) positivity and clinical relapse in patients with vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCA).
  95. ncbi Antiproteinase 3 antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis
    Javier D Finkielman
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 147:611-9. 2007
    ..The utility of antineutrophil cytoplasmic antibody (ANCA) levels to guide the management of patients with Wegener granulomatosis remains controversial...
  96. ncbi Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease
    M Peeters
    Department of Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 96:730-4. 2001
    ..The combination of tests is probably more powerful, although, clinical subgroups still need to be defined. The usefulness of these markers in indeterminate colitis needs to be studied prospectively...
  97. ncbi Antineutrophil cytoplasmic antibodies (ANCA)
    A Radice
    Department of Nephrology and Immunology, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milano, Italy
    Autoimmunity 38:93-103. 2005
    b>Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis...
  98. ncbi Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long-term followup study
    Marjan C Slot
    University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 53:108-13. 2005
    To test whether antineutrophil cytoplasmic antibodies (ANCA) and ANCA-associated vasculitis (AAV) are not only induced during treatment with antithyroid drugs, but can also become evident when medication has been ceased, possibly after ..
  99. pmc Clinical review: Vasculitis on the intensive care unit--part 1: diagnosis
    David Semple
    Worthing Hospital, Worthing, UK
    Crit Care 9:92-7. 2005
    ..The development of assays for antineutrophil cytoplasmic antibodies has aided the diagnosis of Wegener's granulomatosis and microscopic polyangiitis...
  100. ncbi [Vasculitis with renal involvement and antineutrophil cytoplasmic antibodies (ANCA) in a child receiving benzylthiouracil]
    Mongia Hachicha
    Service de Pediatrie, CHU Hedi Chaker, 3029 Sfax, Tunisie
    Nephrol Ther 3:147-51. 2007
    Vasculitis associated to antineutrophil cytoplasmic antibodies (ANCA) is a rare complication of therapy with antithyroid medication...
  101. ncbi Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis
    Karina A Keogh
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arthritis Rheum 52:262-8. 2005
    ..To assess the clinical effects of rituximab therapy in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)...

Research Grants29

  1. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ....
  2. IDENTIFICATION AND VALIDATION OF BIOMARKERS FOR VASCULITIS
    Paul A Monach; Fiscal Year: 2010
    ..Results of these studies will also be important in the design of future clinical trials in these rare but important diseases and will provide insight into biomarker development in other types of vasculitis. ..
  3. ROLE OF DPPI &SERINE PROTEASES IN INFLAMMATORY DISEASES
    CHRISTINE T PHAM; Fiscal Year: 2012
    ..We propose to determine whether all ANCAs are potentially pathogenic. We also hypothesize that decreased expression of complement regulators in the kidney may be a determinant that influences disease severity in target organ. ..
  4. GENETIC LINKAGE BETWEEN UC AND THE HLA CLASS II LOCI
    Richard Duerr; Fiscal Year: 1999
    ..method of linkage analysis; determine whether there is increased concordance for perinuclear antineutrophil cytoplasmic antibodies, extent of colonic involvement with UC, or need for colectomy because of medically refractory ..
  5. PROTEINASE 3 SPECIFIC IMMUNOTHERAPY OF LEUKEMIA
    Jeffrey Molldrem; Fiscal Year: 2002
    ..Lastly, other synthetic HLA-A2-associated peptides from Pr3 will be investigated for their potential to elicit peptide-specific CTL from donor PBMC in vitro and then tested for ability to lyse myeloid leukemia. ..
  6. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..This project will create a new program involving investigators who have not previously worked together, while building on institutional strengths and programmatic initiatives. ..
  7. IBD: ROLE OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
    Stephan Targan; Fiscal Year: 1993
    ....
  8. Genetic Polymorphisms in Wegener's Granulomatosis
    JEFFREY EDBERG; Fiscal Year: 2003
    ....
  9. EFFECTS OF PR3-ANCA ON DISEASE PHENOTYPE
    Ulrich Specks; Fiscal Year: 2001
    ..WG and MPA are associated with circulating autoantibodies, antineutrophil cytoplasmic antibodies (ANCA)...
  10. PR3-ANCA Subsets and Disease Phenotype
    Ulrich Specks; Fiscal Year: 2005
    Wegener's granulomatosis (WG) is the prototype of vasculitides associated with antineutrophil cytoplasmic antibodies (ANCA). The determinants of specific organ involvement and disease relapses remain unclear...
  11. Clinical Research for Rare Diseases: Opportunities, Challenges, and Solutions
    Peter Merkel; Fiscal Year: 2007
    ..If this conference proves successful, we plan on having similar sessions attached to future RDCRC meetings. [unreadable] [unreadable] [unreadable]..
  12. Studies in Scleroderma and Cystic Fibrosis Osteoporosis
    Peter Merkel; Fiscal Year: 2005
    ..A unique seminar and a series of support services at the host institution will further complement the training program. ..
  13. Vasculitis Clinical Research Network (VCRN)
    Peter Merkel; Fiscal Year: 2008
    ..AIM 5. Build and contribute to an electronic website resource with substantive content for clinicians, researchers, and patients. ..
  14. B Cell Superantigen Immune Complex Tissue Inflammation
    Arnold Levinson; Fiscal Year: 2008
    ..abstract_text> ..
  15. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  16. Are IQs low in offspring of euthyroid women with low T4
    Wendy Craig; Fiscal Year: 2008
    ..It is intended that the study be continued for five more years (total of 10) in order to obtain additional estimates of neuropsychological development in the children at a time when more extensive testing can be performed. ..
  17. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  18. CYTOKINES AS PREDICTORS OF FLARE IN SLE
    Violeta Rus; Fiscal Year: 2004
    ..abstract_text> ..
  19. Inflammatory Bowel Disease in TCR-Mutant Mice
    Atul Bhan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] ..
  20. Role of Integrins in Pulmonary Fibrosis
    Eric White; Fiscal Year: 2006
    ....
  21. Intrathymic Pathogenesis of Myasthenia Gravis
    Arnold Levinson; Fiscal Year: 2004
    ..These studies provide a novel approach to elucidate the role of the thymus in the pathogenesis of MG. ..
  22. IBD--MUCOSA-SPECIFIC REGULATION OF IFN-GAMMA PRODUCTION
    Stephan Targan; Fiscal Year: 2005
    ..abstract_text> ..
  23. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
  24. Translational Research in Systemic Vasculitis
    John Stone; Fiscal Year: 2006
    ..Stone), using patient samples and clinical data from the Vasculitis Center. ..
  25. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2006
    ..These studies will reveal if MPO-generated oxidants promote atherosclerosis in mouse models, thereby humanizing existing mouse models, and enabling investigations of the role of MPO-mediated oxidation in atherosclerosis. ..
  26. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  27. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  28. Pharmacokinetics & Genomics in Glomerular Diseases
    MELANIE JOY; Fiscal Year: 2008
    ..The selection of collaborators with expertise in the areas of this grant will enhance the career development of Dr. Joy. ..
  29. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..