influenza virus hemagglutinin glycoproteins

Summary

Summary: Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.

Top Publications

  1. ncbi Universal primer set for the full-length amplification of all influenza A viruses
    E Hoffmann
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
    Arch Virol 146:2275-89. 2001
  2. pmc Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls
    Ron A M Fouchier
    Dept of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:2814-22. 2005
  3. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
  4. ncbi Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
    M Hatta
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Science 293:1840-2. 2001
  5. pmc Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
    Ron A M Fouchier
    Department of Virology and National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:1356-61. 2004
  6. pmc Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
    Neal Van Hoeven
    Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 106:3366-71. 2009
  7. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
  8. pmc Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus
    Chang Won Lee
    Southeast Poultry Research Laboratory, US Department of Agriculture, Athens, GA 30605, USA
    J Virol 78:8372-81. 2004
  9. ncbi H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes
    R J Russell
    MRC National Institute for Medical Research, London NW7 1AA, UK
    Virology 325:287-96. 2004
  10. pmc N-linked glycosylation attenuates H3N2 influenza viruses
    David J Vigerust
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Virol 81:8593-600. 2007

Research Grants

Detail Information

Publications258 found, 100 shown here

  1. ncbi Universal primer set for the full-length amplification of all influenza A viruses
    E Hoffmann
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
    Arch Virol 146:2275-89. 2001
    ..The resultant primer set is suitable for all influenza A viruses to generate full-length cDNAs, to subtype viruses, to sequence their DNA, and to construct expression plasmids for reverse genetics systems...
  2. pmc Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls
    Ron A M Fouchier
    Dept of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:2814-22. 2005
    ..We propose that sequence analyses of HA and NA genes of influenza A viruses be used for the rapid identification of existing and novel HA and NA subtypes...
  3. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
    ..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
  4. ncbi Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
    M Hatta
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Science 293:1840-2. 2001
    ..Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection...
  5. pmc Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
    Ron A M Fouchier
    Department of Virology and National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:1356-61. 2004
    ..Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans...
  6. pmc Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
    Neal Van Hoeven
    Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 106:3366-71. 2009
    ..These findings demonstrate that the adaptation of the HA and PB2 proteins are critical for the development of pandemic influenza strains from avian influenza viruses...
  7. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    ....
  8. pmc Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus
    Chang Won Lee
    Southeast Poultry Research Laboratory, US Department of Agriculture, Athens, GA 30605, USA
    J Virol 78:8372-81. 2004
    ....
  9. ncbi H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes
    R J Russell
    MRC National Institute for Medical Research, London NW7 1AA, UK
    Virology 325:287-96. 2004
    ..We also show the roles of carbohydrate side chains in the esterase-fusion domain boundaries in the formation of clade-specific structural markers...
  10. pmc N-linked glycosylation attenuates H3N2 influenza viruses
    David J Vigerust
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    J Virol 81:8593-600. 2007
    ..The continued exploration of interactions between highly glycosylated viruses and surfactant proteins may lead to an improved understanding of the biology within the lung and strategies for viral control...
  11. ncbi Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin
    Manabu Igarashi
    Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001 0020, Japan
    Virology 376:323-9. 2008
    ..We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population...
  12. pmc Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals
    M Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, Russia
    J Virol 74:8502-12. 2000
    ....
  13. pmc Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses
    Jinying Ge
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
    J Virol 81:150-8. 2007
    ..The recombinant NDV vaccine may also have potential use in high-risk human individuals to control the pandemic spread of lethal avian influenza...
  14. pmc Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus
    Chih Jen Wei
    Vaccine Research Center, NIAID, National Institutes of Health, Bldg 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, MD 20892 3005, USA
    J Virol 82:6200-8. 2008
    ..Taken together, these results suggest that recombinant HA proteins as individual or oligomeric trimers can elicit potent neutralizing antibody responses to avian H5N1 influenza viruses...
  15. ncbi New avian influenza A virus subtype combination H5N7 identified in Danish mallard ducks
    K Bragstad
    Department of Virology, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Virus Res 109:181-90. 2005
    ..To our knowledge this is the first report of an H5N7 influenza A virus...
  16. ncbi Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
    Shinya Yamada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Nature 444:378-82. 2006
    ..The amino acid changes that we identify might serve as molecular markers for assessing the pandemic potential of H5N1 field isolates...
  17. pmc Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene
    A H Reid
    Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Proc Natl Acad Sci U S A 96:1651-6. 1999
    ..Phylogenetic analyses suggest that the 1918 virus HA gene, although more closely related to avian strains than any other mammalian sequence, is mammalian and may have been adapting in humans before 1918...
  18. pmc Development and evaluation of an Influenza virus subtype H7N2 vaccine candidate for pandemic preparedness
    Claudia Pappas
    Influenza Division, Mailstop G 16, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 14:1425-32. 2007
    ..These studies indicate that H7N2-PR8 is immunogenic, safe, and protective in animal models; these are the essential attributes to qualify for phase I human clinical trials as a prepandemic vaccine...
  19. ncbi Role of hemagglutinin cleavage for the pathogenicity of influenza virus
    D A Steinhauer
    National Institute for Medical Research, The Ridgeway, London, Mill Hill, NW7 1AA, United Kingdom
    Virology 258:1-20. 1999
    ..Here influenza virus pathogenicity is discussed, with an emphasis on the role of HA0 cleavage as a determining factor...
  20. pmc Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8007, USA
    J Virol 84:1489-503. 2010
    ..The study also identified NA as an independent protective HPAIV antigen in primates. Furthermore, we demonstrated the feasibility of aerosol delivery of NDV-vectored vaccines...
  21. pmc Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification
    Jürgen Stech
    Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Greifswald Insel Riems, Germany
    Nucleic Acids Res 36:e139. 2008
    ..In case the PCR amplicon ends are homologous to the plasmid annealing sites only, this method is suitable for cloning of any insert with conserved termini...
  22. pmc Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza
    Jutta Veits
    Institute of Molecular Biology, Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Boddenblick 5a, D 17493 Greifswald Insel Riems, Germany
    Proc Natl Acad Sci U S A 103:8197-202. 2006
    ..Therefore, recombinant NDVH5m is suitable as a bivalent vaccine against NDV and AIV and may be used as marker vaccine for the control of avian influenza...
  23. pmc Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts
    Dmitry E Shvartsman
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Cell Biol 163:879-88. 2003
    ..Thus, the anchoring mode determines protein-raft interaction dynamics. GPI-anchored and transmembrane proteins can share the same rafts, and different proteins can interact stably or transiently with the same raft domains...
  24. ncbi Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin
    Ming Zhang
    Theoretical Biology Group, Los Alamos National Laboratory, Los Alamos, NM 87544, USA
    Glycobiology 14:1229-46. 2004
    ..Human influenza A hemagglutinin H3 HA1 is accumulating sequons over time, but this trend is not evident in any other avian or human influenza A serotypes...
  25. ncbi Epitope analysis for influenza vaccine design
    Enrique T Munoz
    Department of Bioengineering and Department of Physics and Astronomy, Rice University Houston, TX 77005 1892, USA
    Vaccine 23:1144-8. 2005
    ..The results explain the ineffectiveness of the 2003-2004 influenza vaccine in the United States and provide an accurate measure by which to optimize the effectiveness of future annual influenza vaccines...
  26. pmc Predicting antigenic variants of influenza A/H3N2 viruses
    Min Shi Lee
    MedImmune Vaccines, Mountain View, California 94043, USA
    Emerg Infect Dis 10:1385-90. 2004
    ..The methods described in this study could be applied to predict vaccine-induced cross-reactive antibody responses in humans, which may further improve the selection of vaccine strains...
  27. ncbi Two residues in the hemagglutinin of A/Fujian/411/02-like influenza viruses are responsible for antigenic drift from A/Panama/2007/99
    Hong Jin
    MedImmune Vaccines, Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Virology 336:113-9. 2005
    ....
  28. ncbi Functional balance between haemagglutinin and neuraminidase in influenza virus infections
    Ralf Wagner
    Institut fur Virologie, Philipps Universitat, 35011 Marburg, Germany
    Rev Med Virol 12:159-66. 2002
    ..The resulting decrease in the viral replicative fitness is usually overcome by restoration of the functional balance due to compensatory mutations in HA, NA or both proteins...
  29. pmc Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion
    Sudha Thoennes
    Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Virology 370:403-14. 2008
    ..3 relative to WT. The results are discussed in relation to possible mechanisms by which HA structural rearrangements are initiated at low pH and clade-specific differences near the fusion peptide...
  30. ncbi Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice
    Peter Pushko
    Novavax, Inc, Vaccine Technologies, 1 Taft Court, Rockville, MD 20850, USA
    Vaccine 23:5751-9. 2005
    ..Thus, VLPs represent a potential strategy for the development of human vaccines against avian influenza H9N2 viruses...
  31. pmc Caveolin-1 and -2 in the exocytic pathway of MDCK cells
    P Scheiffele
    Cell Biology Programme, European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    J Cell Biol 140:795-806. 1998
    ..Thus, we suggest that caveolin-1 homooligomers play a role in apical transport...
  32. pmc Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host
    Yuwei Gao
    Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
    PLoS Pathog 5:e1000709. 2009
    ..These amino acids changes in PB2 and HA could serve as important molecular markers for assessing the pandemic potential of H5N1 field isolates...
  33. ncbi Comparison of in vitro replication features of H7N3 influenza viruses from wild ducks and turkeys: potential implications for interspecies transmission
    Simone Giannecchini
    Virology Unit, Department of Public Health, University of Florence, Firenze, Italy
    J Gen Virol 87:171-5. 2006
    ....
  34. pmc Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion
    Makoto Takeda
    Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208 3500, USA
    Proc Natl Acad Sci U S A 100:14610-7. 2003
    ..Taken together, the data suggest that HA clusters in rafts to provide a sufficient concentration of HA in budding virus to mediate efficient virus-cell fusion...
  35. ncbi Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:1143-55. 2006
    ..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza...
  36. ncbi Glycosylation as a target for recognition of influenza viruses by the innate immune system
    Patrick C Reading
    The University of Melbourne, Department of Microbiology and Immunology, Victoria, Australia 3010
    Adv Exp Med Biol 598:279-92. 2007
    ....
  37. pmc The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties
    M Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 73:1146-55. 1999
    ....
  38. pmc Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape
    H Jin
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    EMBO J 16:1236-47. 1997
    ..We propose a model in which the interactions of the cytoplasmic tails of HA and NA with an internal viral component are so important for spherical virion shape that there is dual redundancy in the interactions...
  39. ncbi Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    L J Stern
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge Massachusetts 62138
    Nature 368:215-21. 1994
    ..Twelve hydrogen bonds between conserved HLA-DR1 residues and the main chain of the peptide provide a universal mode of peptide binding, distinct from the strategy used by class I histocompatibility proteins...
  40. pmc A practical approach to genetic screening for influenza virus variants
    S Zou
    Bureau of Microbiology, Laboratory Centre for Disease Control, Tunney s Pasture, Ottawa, Ontario, Canada
    J Clin Microbiol 35:2623-7. 1997
    ..This method should facilitate genetic screening and characterization of influenza virus variants...
  41. ncbi A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
  42. ncbi Single amino acid substitutions in the hemagglutinin of influenza A/Singapore/21/04 (H3N2) increase virus growth in embryonated chicken eggs
    Bin Lu
    MedImmune Vaccines, Inc, 297N Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 24:6691-3. 2006
    ..We showed that a single amino acid substitution of either G186V or A196T in the HA resulted in significantly increased virus replication in eggs without affecting virus antigenicity...
  43. ncbi Avian and human receptor binding by hemagglutinins of influenza A viruses
    R J Russell
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
    Glycoconj J 23:85-92. 2006
    ....
  44. ncbi Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
    James Stevens
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:404-10. 2006
    ....
  45. ncbi HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination
    Nancy A Danke
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Immunol 171:3163-9. 2003
    ....
  46. ncbi Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:1866-70. 2004
    ....
  47. pmc Plasmid-only rescue of influenza A virus vaccine candidates
    J H Schickli
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Philos Trans R Soc Lond B Biol Sci 356:1965-73. 2001
    ..Third, we suggest the use of Newcastle disease virus recombinants expressing influenza virus haemagglutinin proteins of pandemic (epizootic) strains as novel vaccine vectors for use in animals and possibly humans...
  48. ncbi Transmission of equine influenza virus to dogs
    P C Crawford
    College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    Science 310:482-5. 2005
    ..Evidence of infection in pet dogs suggests that this infection may also become enzootic in this population...
  49. ncbi Fusion peptide of influenza hemagglutinin requires a fixed angle boomerang structure for activity
    Alex L Lai
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 281:5760-70. 2006
    ..A specific fixed angle boomerang structure is thus required to support membrane fusion...
  50. pmc Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin
    Samuel T Hess
    Laboratory for Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:965-76. 2005
    ..This work rules out the tested hypothesis for HA over the accessible length scales, yet shows clearly how the spatial distribution of HA depends on lipid composition...
  51. ncbi Structural evidence for recognition of a single epitope by two distinct antibodies
    D Fleury
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, France
    Proteins 40:572-8. 2000
    ..This flexibility allows the humoral immune response to be redundant, a feature that may be useful in achieving longer lasting protection against evolving viral pathogens...
  52. ncbi Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector
    Yongping Jiang
    Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
    Antiviral Res 75:234-41. 2007
    ....
  53. ncbi The global circulation of seasonal influenza A (H3N2) viruses
    Colin A Russell
    Department of Zoology, University of Cambridge, Cambridge, UK
    Science 320:340-6. 2008
    ....
  54. ncbi Phylogenetic and biological characterization of highly pathogenic H5N1 avian influenza viruses (Vietnam 2005) in chickens and ducks
    J Pfeiffer
    Southeast Poultry Research Laboratory, USDA, ARS, 934 College Station Road, Athens, GA 30605, USA
    Virus Res 142:108-20. 2009
    ..The information gained about these viruses provides insight with regards to implementing control programs, including vaccine seed strain selection...
  55. pmc The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
    Rachelle Salomon
    Department of Infectious Diseases, St Jude Children s Research Hospital, and Department of Pathology, University of Tennessee, Memphis, TN 38105, USA
    J Exp Med 203:689-97. 2006
    ..Thus, novel antivirals targeting polymerase proteins should be developed...
  56. ncbi Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trial
    John J Treanor
    University of Rochester, Rochester, NY, USA
    JAMA 297:1577-82. 2007
    ..A high priority in vaccine research is the development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production...
  57. pmc Effect of the addition of oligosaccharides on the biological activities and antigenicity of influenza A/H3N2 virus hemagglutinin
    Yasuhiro Abe
    Department of Bacteriology, Yamagata University School of Medicine, Iida Nishi, Yamagata 990 9585, Japan
    J Virol 78:9605-11. 2004
    ....
  58. pmc Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion
    Rupert J Russell
    Interdisciplinary Center for Human and Avian Influenza Research, School of Biology, University of St Andrews, Fife KY16 9ST, United Kingdom
    Proc Natl Acad Sci U S A 105:17736-41. 2008
    ..The nature of the binding site suggests routes for the chemical modification of TBHQ that could lead to the development of more potent inhibitors of membrane fusion and potential anti-influenza drugs...
  59. ncbi Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005
    ..All data from this project are being deposited, without delay, in public archives...
  60. ncbi H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity
    M N Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Virology 281:156-62. 2001
    ..Peculiar features of surface glycoproteins of H9N2 viruses from Hong Kong suggest an enhanced propensity for introduction into humans and emphasize the importance of poultry in the zoonotic transmission of influenza viruses...
  61. pmc A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 79:11533-6. 2005
    ..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...
  62. pmc Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Virol 83:1742-53. 2009
    ....
  63. pmc Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies
    Nikolai V Kaverin
    D I Ivanovsky Institute of Virology, 123098 Moscow, Russia
    J Virol 81:12911-7. 2007
    ....
  64. pmc Hemagglutinin (HA) proteins from H1 and H3 serotypes of influenza A viruses require different antigen designs for the induction of optimal protective antibody responses as studied by codon-optimized HA DNA vaccines
    Shixia Wang
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605 2397, USA
    J Virol 80:11628-37. 2006
    ..Our findings will have an important impact on future subunit-based flu vaccine development...
  65. pmc The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus
    Amorsolo L Suguitan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rm 3E13C 1, 33 North Drive, MSC 3203, Bethesda, MD 20892 3203, USA
    Virology 395:280-8. 2009
    ....
  66. ncbi Molecular evolution of human influenza A viruses in a local area during eight influenza epidemics from 2000 to 2007
    Hassan Zaraket
    Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1 757, Asahimachi Dori, Niigata, Niigata 951 8510, Japan
    Arch Virol 154:285-95. 2009
    ..Finally, acquisition or loss of N-glycosylation sites was shown to contribute to the evolution of influenza A virus, especially in the case of H3N2, which had a higher tendency to acquire new glycosylation sites...
  67. pmc Minimal aggregate size and minimal fusion unit for the first fusion pore of influenza hemagglutinin-mediated membrane fusion
    J Bentz
    Department of Bioscience, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Biophys J 78:227-45. 2000
    ..Current models for HA-mediated fusion are examined in light of these new constraints on the early structure and evolution of the nascent fusion site. None completely comply with the data...
  68. ncbi Antigenic structure of the haemagglutinin of human influenza A/H2N2 virus
    E Tsuchiya
    Department of Bacteriology, Yamagata University School of Medicine, Iida Nishi, Yamagata 990 9585, Japan
    J Gen Virol 82:2475-84. 2001
    ....
  69. pmc Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957
    Junfeng Liu
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 106:17175-80. 2009
    ..We consider the significance for the development of pandemics, of the existence of avian viruses that can bind to both avian and human receptors...
  70. ncbi Vaccines protect chickens against H5 highly pathogenic avian influenza in the face of genetic changes in field viruses over multiple years
    D E Swayne
    Southeast Poultry Research Laboratory, USDA ARS, 934 College Station Road, Athens, GA 30605, USA
    Vet Microbiol 74:165-72. 2000
    ....
  71. ncbi Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes
    R Medeiros
    Unite de Genetique Moleculaire des Virus Respiratoires, URA 1966 CNRS, Institut Pasteur, 75724 Paris Cedex 15, France
    Virology 289:74-85. 2001
    ..In contrast, simultaneous Ser193Arg and Leu194Ile substitutions that were found to confer the ability to agglutinate sheep erythrocytes increased the affinity of the HA for SAalpha2,3Gal...
  72. ncbi Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture
    S J Baigent
    Compton Laboratory, Division of Molecular Biology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, Newbury, UK
    Virus Res 79:177-85. 2001
    ..The results reinforce the importance of a balance of HA and NA activity for efficient virus exit from, and entry into cells...
  73. pmc Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses
    Aravind Srinivasan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:2800-5. 2008
    ..In summary, this study establishes a quantitative biochemical correlate for influenza A virus transmission...
  74. ncbi Mechanisms of broad cross-protection provided by influenza virus infection and their application to vaccines
    Shin ichi Tamura
    Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Jpn J Infect Dis 58:195-207. 2005
    ..In the near future, some of these trials may provide new, safer and more effective broad-spectrum vaccines than those currently available...
  75. ncbi Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics
    Ming Liu
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Virology 314:580-90. 2003
    ..3/02 (H5N1) but did not provide sterilizing immunity. Thus, reverse genetics allows the inexpensive preparation of standardized, efficacious H5N3 poultry vaccines that may also reduce the reemergence of H5N1 genotypes...
  76. ncbi A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens
    Qunfeng Wu
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
    Mol Immunol 46:2210-7. 2009
    ..These data indicate that the pseudotype baculovirus-mediated vaccine could be utilized as an alternative strategy against the pandemic spread of H5N1 influenza virus...
  77. ncbi Expression and purification of an influenza hemagglutinin--one step closer to a recombinant protein-based influenza vaccine
    Keyang Wang
    Protein Sciences Corporation, 1000 Research Parkway, Meriden, CT 06450, USA
    Vaccine 24:2176-85. 2006
    ..Here, we report an innovative monitoring assay for recombinant HA (rHA) expression and a rapid purification process. Various biochemical analyses indicate that the purified rHA is properly folded and biologically active...
  78. ncbi Virology. Clues to the virulence of H5N1 viruses in humans
    Robert M Krug
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Science 311:1562-3. 2006
  79. pmc pH-dependence of intermediate steps of membrane fusion induced by the influenza fusion peptide
    Ding Kwo Chang
    Institute of Chemistry, Academia Sinica, Taipei, Taiwan 115, Republic of China
    Biochem J 396:557-63. 2006
    ..Our results, along with those from other studies on the pH-dependence of membrane fusion, are used to build a model for the virus-mediated fusion event from the perspective of pH-reversibility...
  80. ncbi The genesis of a pandemic influenza virus
    Charles J Russell
    Department of Infectious Diseases, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Cell 123:368-71. 2005
    ..Meanwhile, Tumpey et al. (2005) reporting in Science show that the reconstructed 1918 Spanish influenza virus kills mice faster than any other influenza virus so far tested...
  81. pmc Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses
    John M Nicholls
    Pathology Department, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong SAR
    Respir Res 8:73. 2007
    ....
  82. ncbi Evolving complexities of influenza virus and its receptors
    John M Nicholls
    Department of Pathology, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR
    Trends Microbiol 16:149-57. 2008
    ..Understanding these additional components is important in comprehending the infection and the transmission of both existing human influenza viruses and newly emerging avian influenza viruses...
  83. ncbi Additional glycosylation at the receptor binding site of the hemagglutinin (HA) for H5 and H7 viruses may be an adaptation to poultry hosts, but does it influence pathogenicity?
    J Banks
    Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Avian Dis 47:942-50. 2003
    ..Although additional glycosylation may not correlate with increased pathogenicity for fowl, it may predispose viruses to become highly pathogenic...
  84. pmc Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics
    Bin Lu
    MedImmune Vaccines, Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA
    J Virol 79:6763-71. 2005
    ..This study demonstrated that the reverse genetics technology could be used to improve the manufacture of the influenza vaccines...
  85. ncbi Binding of influenza viruses to sialic acids: reassortant viruses with A/NWS/33 hemagglutinin bind to alpha2,8-linked sialic acid
    Wenxin Wu
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Virology 325:340-50. 2004
    ..The finding that influenza viruses have the potential to bind to alpha2,8-linked sialic acid is a new influenza virus-receptor interaction pathway...
  86. pmc Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins
    T Latham
    Department of Viral Vaccine Research, Wyeth-Lederle Vaccines, Pearl River, NY 10965, USA
    J Virol 75:6154-65. 2001
    ..The described approach to assembly of wild-type and chimeric influenza VLPs may provide a valuable tool for further investigation of viral morphogenesis and genome packaging as well as for the development of novel vaccines...
  87. pmc Kinetically differentiating influenza hemagglutinin fusion and hemifusion machines
    Aditya Mittal
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Biophys J 85:1713-24. 2003
    ..We also found that the execution time for fusion was faster than that for hemifusion. Thus, we provide the first experimental evidence for fusion and hemifusion arising from different machines...
  88. pmc Amino acid 226 in the hemagglutinin of H4N6 influenza virus determines binding affinity for alpha2,6-linked sialic acid and infectivity levels in primary swine and human respiratory epithelial cells
    Allen C Bateman
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 82:8204-9. 2008
    ..Using specific neuraminidases, we found that irrespective of their relative binding preferences, all of the influenza viruses examined utilized SAalpha2,6Gal to infect swine and human cells...
  89. pmc Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice
    Yumiko Matsuoka
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 83:4704-8. 2009
    ..The presence of additional HA glycosylation sites had less of an effect on virulence than did NA stalk length. The short-stalk NA of H5N1 viruses circulating in Asia may contribute to virulence in humans...
  90. ncbi Rapid molecular analysis of the haemagglutinin gene of human influenza A H3N2 viruses isolated in spain from 1996 to 2000
    M T Coiras
    Servicio de Virologia, Centro Nacional de Microbiologia (CNM, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Arch Virol 146:2133-47. 2001
    ..This rapid, simple and variant-specific procedure could, therefore, be used to rapidly screen clinical specimens prior to more detailed antigenic and genetic analyses...
  91. pmc Glycans on influenza hemagglutinin affect receptor binding and immune response
    Cheng Chi Wang
    Genomics Research Center, Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan
    Proc Natl Acad Sci U S A 106:18137-42. 2009
    ..Thus, removal of structurally nonessential glycans on viral surface glycoproteins may be a very effective and general approach for vaccine design against influenza and other human viruses...
  92. pmc Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells
    Y Kawaoka
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, TN 38101
    Proc Natl Acad Sci U S A 85:324-8. 1988
    ....
  93. pmc Variation and infectivity neutralization in influenza
    Marcel Knossow
    CNRS Laboratoire d Enzymologie et Biochimie Structurales, Gif sur Yvette Cedex, France
    Immunology 119:1-7. 2006
    ..In addition, we consider changes that may be required before the current avian H5 viruses could pass from human to human...
  94. ncbi Mismatched hemagglutinin and neuraminidase specificities in recent human H3N2 influenza viruses
    Upma Gulati
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Virology 339:12-20. 2005
    ..It will be important to monitor efficacy of neuraminidase inhibitors in case there are NA-resistant receptors in the human respiratory tract that allow the viruses to be less dependent on NA activity...
  95. ncbi Positive selection on the H3 hemagglutinin gene of human influenza virus A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California at Irvine 92697, USA
    Mol Biol Evol 16:1457-65. 1999
    ..Our results suggest that future studies of positive selection should focus on changes assigned to the internal branches, as certain of these changes may have predictive value for identifying future successful epidemic variants...
  96. ncbi Predicting the evolution of human influenza A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 286:1921-5. 1999
    ..However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift...
  97. ncbi Protection of chickens from lethal avian influenza A virus infection by live-virus vaccination with infectious laryngotracheitis virus recombinants expressing the hemagglutinin (H5) gene
    D Lüschow
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498, Insel Riems, Germany
    Vaccine 19:4249-59. 2001
    ..Thus, although attenuation remains to be improved, genetically engineered ILTV live-virus vaccines might be used as vectors to protect chickens also against other pathogens...
  98. ncbi Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans
    J J Treanor
    Infectious Diseases Unit, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Vaccine 19:1732-7. 2001
    ..These results suggest that baculovirus-expressed H5 HA can induce functional antibody in individuals who have not had prior exposure to H5 viruses, but that further studies to improve the immunogenicity of the vaccine are needed...
  99. ncbi Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses
    Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Biol Pharm Bull 28:399-408. 2005
    ....
  100. pmc Nonreplicating vaccinia virus vectors expressing the H5 influenza virus hemagglutinin produced in modified Vero cells induce robust protection
    Josef Mayrhofer
    Baxter BioScience, Biomedical Research Center, Uferstrasse 15, A 2304 Orth Donau, Austria
    J Virol 83:5192-203. 2009
    ..Thus, the nonreplicating recombinant vaccinia virus vectors are promising vaccine candidates that induce a broad immune response and can be produced in an egg-independent and adjuvant-independent manner in a proven vector system...
  101. pmc Generation of a highly pathogenic avian influenza A virus from an avirulent field isolate by passaging in chickens
    T Ito
    Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680 8553, Japan
    J Virol 75:4439-43. 2001
    ..These results demonstrate that avirulent viruses maintained in wild waterfowl in nature and bearing the consensus avirulence type sequence R-E-T-R have the potential to become highly pathogenic while circulating in chickens...

Research Grants39

  1. Development of a DNA Vaccine Against Influenza Virus
    Lawrence Smith; Fiscal Year: 2005
    ..These efforts are designed to be completed within 1 year in a manner that will generate an influenza DNA vaccine that can be manufactured for long-term stockpile. ..
  2. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2006
    ....
  3. Predicting the Evolution of Human Influenza
    Robin Bush; Fiscal Year: 2006
    ..4) The generality of the results from study of H3N2 will be tested by contrasting them with similar studies of influenza A subtype H1N1 and influenza B. ..
  4. COMBINATION CHEMOTHERAPY FOR PANDEMIC INFLUENZA
    Robert Webster; Fiscal Year: 2005
    ....
  5. STRUCTURAL IMMUNOLOGY OF CLASSICAL AND NON-CLASSICAL MHC
    Ian A Wilson; Fiscal Year: 2010
    ..abstract_text> ..
  6. Viral migration and predicting viral changes
    WALTER FITCH; Fiscal Year: 2006
    ..The accomplishment of these aims should improve the ability of the field to provide better treatment and better vaccines in the flight against human influenza. [unreadable] [unreadable]..
  7. Influenza HA in SHIV VLPS for mucosal vaccination
    Qizhi Yao; Fiscal Year: 2006
    ..abstract_text> ..
  8. Ginkgo Biloba Enhances Therapeutic HIV Vaccination
    Qizhi Yao; Fiscal Year: 2006
    ..Furthermore, it will have the potential to initiate translational and early phase clinical trials to investigate this CAM and VLPs approach to treat HIV/AIDS and its complications. [unreadable] [unreadable]..
  9. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
    ..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
  10. Mechanisms of Effector CD4 Cell Tolerization
    Adam Adler; Fiscal Year: 2008
    ..This proposal will examine the cellular and molecular mechanisms that govern the regulation of this novel peripheral tolerization pathway. [unreadable] [unreadable]..
  11. Avian Influenza Surveillance in Thailand-Studies at Human-Animal Interface
    Pilaipan Puthavathana; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  13. Virulence factors of influenza virus: The NS1 protein
    Adolfo Garcia Sastre; Fiscal Year: 2010
    ..abstract_text> ..
  14. ANTIBODIES AS CATALYSTS
    Ian Wilson; Fiscal Year: 2004
    ..In this way, the enormous potential power of the immune system can be harnessed to rapidly develop tailor-made catalysts in a few weeks, compared to the billions of years it has taken for evolution of natural enzymes. ..
  15. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  16. Comparing Toleragenic Versus Immunogenic APC Function
    Adam Adler; Fiscal Year: 2003
    ..The specific aims are to: 1) identify the tAPC; 2) characterize functional properties of the tAPC; and 3) analyze how the tAPC deliver its toleragenic signal. ..
  17. RESPONSIVENESS OF GNRH RECEPTOR SIGNALING
    JIMMY NEILL; Fiscal Year: 2002
    ....
  18. ENHANCEMENT OF HIV IMMUNOGENICITY BY INFLUENZA VIRUS
    Qizhi Yao; Fiscal Year: 2002
    ..We will be especially interested in testing in CD4+ T cell knock-out mice if such immunization can also induce antibody responses to HIV and whether HIV specific neutralizing antibody responses will also be induced. ..
  19. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  20. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  21. RECOGNITION AND SORTING OF GLYCOPROTEINS
    Michael Roth; Fiscal Year: 2002
    ....
  22. X-ray structures of HIV-1 neutralizing sites
    Ian Wilson; Fiscal Year: 2008
    ..These studies all have the common goal of providing essential structural information on HIV-1 proteins and anti-HIV-1 antibodies to help guide efforts in vaccine and inhibitor design. [unreadable] [unreadable]..
  23. A Genome-Derived, Epitope-Driven H. Pylori Vaccine
    Anne De Groot; Fiscal Year: 2006
    ..pylori disease as our correlate of efficacy. ..
  24. Biodefense vaccine for pandemic influenza
    Lawrence Smith; Fiscal Year: 2005
    ..FINAL MILESTONE 3: Completion of Aim 2 and completion of IND ..
  25. Oral Delivery of DNA Vaccines
    FRANK ORSON; Fiscal Year: 2003
    ....
  26. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  27. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  28. Optimization of a Multivalent Tuberculosis Vaccine
    Anne De Groot; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Development of De-immunized Botulinum Neurotoxin Type A for Dystonia
    Anne De Groot; Fiscal Year: 2008
    ..Public Health Relatedness: Knowledge of the elements of botulinum neurotoxin type A that give rise to its immunogenicity will contribute to the development of improved dystonia therapy. [unreadable] [unreadable] [unreadable]..
  30. 2nd Annual Vaccine Renaissance Conference, RI
    Anne De Groot; Fiscal Year: 2006
    ..More than 80 participants attended that 1st conference from the[unreadable] New England region and beyond. ..
  31. Epitope Driven HIV Vaccine Development
    Anne De Groot; Fiscal Year: 2005
    ..The final product of this joint effort will be a set of plasmids to be combined in an epitope-driven, oligonucleotide-based DNA cocktail vaccine for HIV. ..
  32. Novel Smallpox Vaccine Derived from VV/VAR Immunome
    Anne De Groot; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  33. A GENOME-DERIVED, EPITOPE-DRIVEN TULAREMIA VACCINE
    Anne De Groot; Fiscal Year: 2005
    ..abstract_text> ..
  34. Induction of tolerance to islet cell transplants
    Bellur Prabhakar; Fiscal Year: 2004
    ..Under aim 3: we will prepare a new BiAb using an islet cell specific antibody and anti-CTLA-4 antibody to test ability to prevent and treat Type I DM in a murine model of spontaneous diabetes. ..
  35. Novel human gene-IG20-potential role in cancer therapy
    Bellur Prabhakar; Fiscal Year: 2009
    ..These studies will lead to a clearer understanding of the mechanism of action of IG20/DENN-SV in ovarian cancer. ..
  36. Becton Dickinson Flow Cytometry System
    Bellur Prabhakar; Fiscal Year: 2002
    ..Careful evaluation of the three available systems prompted our users group to recommend the BD FACS Vantage SE since it would satisfy the needs of our institution's NIH-funded investigators. ..
  37. XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXES
    Ian Wilson; Fiscal Year: 2001
    ..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..
  38. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2003
    ..Such a model would facilitate a thorough understanding of the regulation of the immune response to TSHR with implications for the development of novel therapeutics. ..
  39. TRANSFECTANT INFLUENZA VIRUSES IN CANCER THERAPY
    Adolfo Garcia Sastre; Fiscal Year: 2002
    ..The proposed research may advance the field of cancer therapy towards possible novel ways to treat human tumors and prolong survival of cancer patients. ..