hla antigens

Summary

Summary: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

Top Publications

  1. ncbi CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    Photini Kiepiela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nat Med 13:46-53. 2007
  2. ncbi HLA DNA typing: past, present, and future
    H Erlich
    Roche Molecular Systems, Inc, Pleasanton, CA, USA
    Tissue Antigens 80:1-11. 2012
  3. pmc High-throughput, high-fidelity HLA genotyping with deep sequencing
    Chunlin Wang
    Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94003, USA
    Proc Natl Acad Sci U S A 109:8676-81. 2012
  4. pmc The IMGT/HLA database
    James Robinson
    Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Nucleic Acids Res 39:D1171-6. 2011
  5. pmc HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes
    Alexander T Dilthey
    Department of Statistics, University of Oxford, Oxford, UK
    Bioinformatics 27:968-72. 2011
  6. ncbi Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers
    T Shiina
    Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tissue Antigens 80:305-16. 2012
  7. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
  8. pmc NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11
    Claus Lundegaard
    CBS, Department of Systems Biology, Technical University of Denmark DTU, Kemitorvet Build 208, 2800 Lyngby, Denmark
    Nucleic Acids Res 36:W509-12. 2008
  9. pmc Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Galit Alter
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 204:3027-36. 2007
  10. ncbi High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007

Detail Information

Publications278 found, 100 shown here

  1. ncbi CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    Photini Kiepiela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nat Med 13:46-53. 2007
    ..These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation...
  2. ncbi HLA DNA typing: past, present, and future
    H Erlich
    Roche Molecular Systems, Inc, Pleasanton, CA, USA
    Tissue Antigens 80:1-11. 2012
    ..Here, our lab's efforts to develop high-resolution and high-throughput HLA DNA typing using the 454 Sequencing System are reviewed, and the potential future developments and applications of HLA DNA typing are discussed...
  3. pmc High-throughput, high-fidelity HLA genotyping with deep sequencing
    Chunlin Wang
    Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94003, USA
    Proc Natl Acad Sci U S A 109:8676-81. 2012
    ..Furthermore, this approach can also be extended to include other polymorphic genes...
  4. pmc The IMGT/HLA database
    James Robinson
    Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Nucleic Acids Res 39:D1171-6. 2011
    ..ebi.ac.uk/imgt/hla/. Regular updates to the web site ensure that new and confirmatory sequences are dispersed to the HLA community, and the wider research and clinical communities...
  5. pmc HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes
    Alexander T Dilthey
    Department of Statistics, University of Oxford, Oxford, UK
    Bioinformatics 27:968-72. 2011
    ..Here, we present a modification of the original algorithm implemented in a freely available software suite that combines local data preparation and QC with probabilistic imputation through a remote server...
  6. ncbi Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers
    T Shiina
    Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tissue Antigens 80:305-16. 2012
    ..Therefore, the SS-SBT method described here is a superior and effective HLA DNA typing method to efficiently detect new HLA alleles and null alleles without ambiguity...
  7. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
    ..At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo...
  8. pmc NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11
    Claus Lundegaard
    CBS, Department of Systems Biology, Technical University of Denmark DTU, Kemitorvet Build 208, 2800 Lyngby, Denmark
    Nucleic Acids Res 36:W509-12. 2008
    ..Here, the performance is further validated and benchmarked using a large set of newly published affinity data, non-redundant to the training set. The server is free of use and available at: http://www.cbs.dtu.dk/services/NetMHC...
  9. pmc Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Galit Alter
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 204:3027-36. 2007
    ..These data provide the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication...
  10. ncbi High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007
    ..High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival...
  11. pmc A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 38:1166-72. 2006
    ....
  12. ncbi Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
    ..Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells...
  13. pmc High-resolution, high-throughput HLA genotyping by next-generation sequencing
    G Bentley
    Department of Human Genetics, Roche Molecular Systems Inc, Pleasanton, CA 94588, USA
    Tissue Antigens 74:393-403. 2009
    ....
  14. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
    ..These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response...
  15. pmc Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing
    Simon M Lank
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI, USA
    BMC Genomics 13:378. 2012
    ..Achieving high-resolution typing is also becoming more challenging with traditional methods as the database of known HLA alleles increases...
  16. ncbi Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk
    V Parikka
    Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, PO Box 52, 20521 Turku, Finland
    Diabetologia 55:1926-36. 2012
    ....
  17. pmc Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project
    Roger Horton
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Immunogenetics 60:1-18. 2008
    ....
  18. pmc Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    Gideon M Hirschfield
    University of Toronto and Liver Center, Toronto Western Hospital, Toronto, ON, Canada
    N Engl J Med 360:2544-55. 2009
    ..Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown...
  19. ncbi The HLA genomic loci map: expression, interaction, diversity and disease
    Takashi Shiina
    Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan
    J Hum Genet 54:15-39. 2009
    ....
  20. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
    ..At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not...
  21. pmc A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells
    S Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Exp Med 189:1093-100. 1999
    ..Therefore, given that HLA-G expression is restricted to fetal trophoblast cells, KIR2DL4 may provide important signals to maternal NK decidual cells that interact with trophoblast cells at the maternal-fetal interface during pregnancy...
  22. ncbi Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    John E Wagner
    Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
    Blood 100:1611-8. 2002
    ..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less...
  23. ncbi Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands
    Wim Jennes
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    J Immunol 177:6588-92. 2006
    ..In addition, exposed seronegatives more frequently possessed AB KIR genotypes, which contain more activating KIR. The data support an important role for NK cells and KIR/HLA interactions in antiviral immunity...
  24. pmc Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
    Jonathan M Carlson
    Microsoft Research, eScience Group, Los Angeles, California, USA
    J Virol 86:5230-43. 2012
    ..Given the clinical correlates of immune escape, such heterogeneity suggests that certain epitopes will lead to discordant outcomes if applied universally in a vaccine...
  25. ncbi Rapid high-throughput human leukocyte antigen typing by massively parallel pyrosequencing for high-resolution allele identification
    Christian Gabriel
    Red Cross Transfusion Service of Upper Austria, Krankenhausstrasse 7, 4017 Linz, Austria
    Hum Immunol 70:960-4. 2009
    ..Furthermore, current investments for increased read lengths and fully automated molecular diagnostic software tools, using original GS-FLX data file formats, will enhance this novel HLA typing strategy in the near future...
  26. ncbi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  27. ncbi Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique CEA DSV DRM, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Blood 109:2040-8. 2007
    ..These data re-emphasize the significance of HLA-G expression in normal and pathologic situations...
  28. pmc HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Département de Recherche Médicale Direction des Sciences du Vivant, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris 10, France
    Proc Natl Acad Sci U S A 101:7064-9. 2004
    ..Thus, HLA-G+ APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance...
  29. ncbi Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G
    Aisha Nasef
    INSERM, U832, Universite Pierre et Marie Curie PARIS6, Paris, France
    Transplantation 84:231-7. 2007
    ..Histocompatibility locus antigen (HLA)-G is a nonclassical major histocompatibility complex class I antigen with strong immune-inhibitory properties...
  30. pmc Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag
    Jonathan M Carlson
    eScience Group, Microsoft Research, Redmond, Washington, United States of America
    PLoS Comput Biol 4:e1000225. 2008
    ..Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes...
  31. ncbi High-resolution HLA alleles and haplotypes in the United States population
    Martin Maiers
    National Marrow Donor Program, Minneapolis, Minnesota, USA
    Hum Immunol 68:779-88. 2007
    ..The electronic availability of this information will be useful for projects central to the typing and use of population data in HLA applications...
  32. pmc Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 103:16412-7. 2006
    ..These results suggest that subtle structural differences between LILRB family members cause the distinct binding specificities to various forms of HLA-G and other MHCIs, which may in turn regulate immune suppression...
  33. pmc Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
    John D Rioux
    Research Center, Université de Montréal and Montreal Heart Institute, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 106:18680-5. 2009
    ..The data demonstrate that MHC associations with autoimmune diseases result from complex, multilocus effects that span the entire region...
  34. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
    ..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
  35. pmc Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations
    Marcelo A Fernandez Vina
    Department of Pathology, Stanford University, Stanford, CA, USA
    Philos Trans R Soc Lond B Biol Sci 367:820-9. 2012
    ..Therefore, allelic diversity in HLA should be analysed in conjunction with other genetic markers to accurately track the migrations of modern humans...
  36. pmc A multi-site study using high-resolution HLA genotyping by next generation sequencing
    C L Holcomb
    Roche Molecular Systems Inc RMS, Pleasanton, CA 94588, USA
    Tissue Antigens 77:206-17. 2011
    ..3% to 99.4% for the eight sites, with overall concordance of 97.2%. We conclude that clonal pyrosequencing using the GS FLX platform and CONEXIO ATF software allows reliable identification of HLA genotypes at high resolution...
  37. pmc Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:8856-61. 2003
    ....
  38. ncbi Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics
    Pedro Cano
    University of Texas M D Anderson Cancer Center, HLA Typing Laboratory, Houston, Texas 77054, USA
    Hum Immunol 68:392-417. 2007
    ..The criteria were established for proficiency testing, which could be a valuable tool when making clinical histocompatibility decisions...
  39. ncbi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
    ..The aims of this study were to investigate to which extent HLA-DSA detected by SAFB represent a risk for antibody-mediated rejection (AMR) and diminished allograft survival, and to define HLA-DSA characteristics predictive for AMR...
  40. ncbi Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation
    Paola Contini
    Department of Internal Medicine DIMI, University of Genova, Genova, Italy
    Eur J Immunol 33:125-34. 2003
    ..In contrast, non-classical HLA class I molecules may exert immunomodulatory effects in particular conditions characterized by elevated sHLA-G levels such as pregnancy and some neoplastic diseases...
  41. ncbi Vaccine-induced allo-HLA-reactive memory T cells in a kidney transplantation candidate
    Lloyd J A D'Orsogna
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Transplantation 91:645-51. 2011
    ..However, the effect of successful vaccination on the alloreactive memory T-cell repertoire is unclear. We hypothesized that vaccination could specifically induce allo-HLA-reactive memory T cells...
  42. pmc Sequence capture and next generation resequencing of the MHC region highlights potential transplantation determinants in HLA identical haematopoietic stem cell transplantation
    Johannes Pröll
    Red Cross Transfusion Service for Upper Austria, Linz
    DNA Res 18:201-10. 2011
    ..Taken together, the presented data show that sequence capture and massively parallel pyrosequencing can be used as a new tool for risk assessment in the setting of allogeneic stem cell transplantation...
  43. ncbi HLArestrictor--a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides
    Malene Erup Larsen
    Center for Biological Sequence Analysis, DTU Systems Biology, Building 208, Technical University of Denmark, DK 2800, Lyngby, Denmark
    Immunogenetics 63:43-55. 2011
    ..Thus, HLArestrictor should be a valuable tool in any T cell epitope discovery process aimed at identifying new epitopes from infectious diseases and other disease models...
  44. pmc Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 116:4700-2. 2010
    ..These data indicate that the adoptive transfer of partially HLA-mismatched virus-specific CTL is safe despite in vitro recognition of recipient HLA molecules...
  45. ncbi Soluble HLA-G inhibits cell cycle progression in human alloreactive T lymphocytes
    Rajia Bahri
    Institut National de la Santé et de la Recherche Médicale Unité 542, Villejuif, France
    J Immunol 176:1331-9. 2006
    ..In contrast, it induced an accumulation of p27kip, but not p21cip, in activated T cells. HLA-G does not induce apoptosis of alloreactive T cells, but induces p27kip1 and inhibits cell cycle progression...
  46. pmc Disulfide bond-mediated dimerization of HLA-G on the cell surface
    Jonathan E Boyson
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 and Institute of Molecular Genetics, 142 20 Prague, Czech Republic
    Proc Natl Acad Sci U S A 99:16180-5. 2002
    ..The cell-surface expression of dimerized HLA-G molecules may have implications for HLA-Greceptor interactions and for the search for specific receptors that bind HLA-G...
  47. ncbi Tolerization of dendritic cells by HLA-G
    Vladimir Ristich
    Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta 30912 2600, USA
    Eur J Immunol 35:1133-42. 2005
    ..These findings provide support that HLA-G is an important tolerogenic molecule on DC for the acceptance of a semiallogeneic fetus and transplanted tissue/organ...
  48. ncbi All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies
    Po Chang Lee
    Department of Surgery, Medical College, University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan, Taiwan 704
    Transplantation 74:1192-4. 2002
    ..Recent studies show that almost all patients who have rejected a kidney transplant had human leukocyte antigen (HLA) antibodies. In this study, we sought to determine whether patients develop HLA antibodies before chronic rejection...
  49. pmc Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: a CD4+ T cell regulatory mechanism
    N Lila
    , , Direction des Sciences du Vivant, , , 1 avenue Claude-Vellefaux, 75010 Paris, France
    Proc Natl Acad Sci U S A 98:12150-5. 2001
    ..This inhibition may be reversed by adding the anti-HLA-G 87G antibody to a mixed lymphocyte culture. That may indicate a previously uncharacterized regulatory mechanism of CD4(+) T cell proliferative response...
  50. ncbi HLA-G: from biology to clinical benefits
    Edgardo D Carosella
    Institut Universitaire d Hematologie, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 75010 Paris, France
    Trends Immunol 29:125-32. 2008
    ..These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels...
  51. pmc Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens
    A Ishitani
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092
    Proc Natl Acad Sci U S A 89:3947-51. 1992
    ..These findings are discussed in terms of potential functions of the alternative HLA-G proteins...
  52. pmc HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
    Zabrina L Brumme
    Ragon Institute of MGH, MIT and Harvard, Charlestown, MA, USA
    PLoS ONE 4:e6687. 2009
    ..Results are organized into protein-wide escape maps illustrating the sites and pathways of HLA-driven viral evolution...
  53. ncbi Hypoxia modulates HLA-G gene expression in tumor cells
    Gael Mouillot
    Commissariat a l Energie Atomique, Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Hum Immunol 68:277-85. 2007
    ..Finally, we demonstrated for the first time that the modulation of HLA-G gene expression is dependent of HIF-1 stabilization and thus might be relevant for the control of HLA-G gene expression in hypoxic tumors...
  54. ncbi HLA-G and immune tolerance in pregnancy
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7400, USA
    FASEB J 19:681-93. 2005
    ....
  55. ncbi The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    G B Cohen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:661-71. 1999
    ..These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV...
  56. ncbi Beyond the increasing complexity of the immunomodulatory HLA-G molecule
    Edgardo D Carosella
    CEA, IBM, Service de Recherches en Hemato Immunologie, Paris, France
    Blood 111:4862-70. 2008
    ..We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant...
  57. ncbi HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms
    Thomas Vauvert F Hviid
    Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Denmark
    Immunogenetics 56:135-41. 2004
    ..In conclusion, this study indicates that polymorphisms in the 3'UTR and the 5'URR of the HLA-G gene may influence the expression of sHLA-G of possible importance in pathological pregnancies and also in organ transplantation...
  58. ncbi HLA-G in human reproduction: aspects of genetics, function and pregnancy complications
    Thomas Vauvert F Hviid
    Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet
    Hum Reprod Update 12:209-32. 2006
    ..Finally, aspects of a possible role of HLA-G in organ transplantation and in inflammatory or autoimmune disease, and of HLA-G in an evolutionary context, are also briefly examined...
  59. ncbi Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure
    Kazuo Mizutani
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 5:2265-72. 2005
    ..These antibodies found in the peripheral circulation, were not necessarily donor-specific, but their association with failure is consistent with a causality hypothesis...
  60. ncbi Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
    Stephanie Coupel
    Institut National de la Sante et de la Recherche Medicale, Unit 643, Institut de Transplantation et de Recherche en Transplantation, Nantes, France
    Blood 109:2806-14. 2007
    ..The present identification of soluble HLA-E molecules may have important implications in understanding the pathogenesis of immune-mediated vascular diseases and for the diagnosis and monitoring of patients...
  61. ncbi HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms
    Erik Thorsby
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Rikshospitalet, Oslo, Norway
    Transpl Immunol 14:175-82. 2005
    ..g. HLA-B27 for ankylosing spondylitis) and others which may be more common for several diseases. This will be briefly reviewed in the following...
  62. ncbi HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à L Energie Atomique DRM DSV, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    FASEB J 19:662-4. 2005
    ..Functionally, up-regulation of inhibitory receptors in immune cells before stimulation might increase their activation thresholds and participate in immune escape mechanisms...
  63. ncbi Allo-HLA reactivity of virus-specific memory T cells is common
    Avital L Amir
    Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Blood 115:3146-57. 2010
    ....
  64. pmc Common and well-documented HLA alleles: 2012 update to the CWD catalogue
    S J Mack
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 81:194-203. 2013
    ..This version 2.0.0 of the CWD catalogue is available online at cwd.immunogenomics.org, and will be integrated into the Allele Frequencies Net Database, the IMGT/HLA Database and National Marrow Donor Program's bioinformatics web pages...
  65. ncbi Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival
    P I Terasaki
    Terasaki Foundation Laboratory, Los Angeles, CA, USA
    Am J Transplant 7:408-15. 2007
    ..0003) compared to 92% survival in those with no antibodies. In conclusion, these two prospective trials, after 1 and 4 years, provided strong evidence that HLA and MICA antibodies are associated with graft failure...
  66. ncbi Polymorphism in the 5' upstream regulatory and 3' untranslated regions of the HLA-G gene in relation to soluble HLA-G and IL-10 expression
    Thomas Vauvert F Hviid
    Department of Clinical Biochemistry, Roskilde University Hospital, Roskilde, Denmark
    Hum Immunol 67:53-62. 2006
    ..This study indicates that polymorphism in the 5'-URR of the HLA-G gene may have functional significance, although a new line of investigations is needed to elucidate these findings...
  67. ncbi Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis
    Sandra Nischwitz
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neuroimmunol 227:162-6. 2010
    ..No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433...
  68. pmc Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Diabetes 59:3174-80. 2010
    ..To investigate whether enterovirus infections predict progression to type 1 diabetes in genetically predisposed children repeatedly positive for islet autoantibodies...
  69. ncbi New reservoirs of HLA alleles: pools of rare variants enhance immune defense
    William Klitz
    School of Public Health, University of California, Berkeley, CA, USA
    Trends Genet 28:480-6. 2012
    ..e., a single copy), they have typically been thought of as having little consequence. However, this large population of rare yet potentially valuable new alleles may contribute to pathogen defense...
  70. ncbi KIR: diverse, rapidly evolving receptors of innate and adaptive immunity
    Carlos Vilches
    Servicio de Inmunologia, Hospital Universitario Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
    Annu Rev Immunol 20:217-51. 2002
    ..This diversity likely contributes variability to the function of NK cells and T-lymphocytes by modulating innate and adaptive immune responses to specific challenges...
  71. pmc Optimal HLA matching in hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, United States
    Curr Opin Immunol 20:588-93. 2008
    ..Optimizing the overall outcome of hematopoietic cell transplantation requires an appreciation for the relative importance of HLA factors with respect to other non-genetic factors that also influence transplant outcome...
  72. pmc A community standard for immunogenomic data reporting and analysis: proposal for a STrengthening the REporting of Immunogenomic Studies statement
    J A Hollenbach
    Center for Genetics, Children s Hospital and Research Center Oakland, Oakland, CA, USA
    Tissue Antigens 78:333-44. 2011
    ..As with the STREGA guidelines, the intent behind STREIS is not to dictate the design of immunogenomic studies, but to ensure consistent and transparent reporting of research, facilitating the synthesis of HLA and KIR data across studies...
  73. ncbi Allele frequency estimation from ambiguous data: using resampling schema in validating frequency estimates and in selective neutrality testing
    José Manuel Nunes
    Laboratory of Anthropology, Genetics and Peopling History AGP, Anthropology Unit, Department of Genetics and Evolution, University of Geneva, Switzerland
    Hum Biol 83:437-47. 2011
    ..Moreover, resampling appears to be the unique way to test selective neutrality when only frequency data are available to describe the genetic structure of populations...
  74. ncbi High-resolution human leukocyte antigen allele and haplotype frequencies of the Polish population based on 20,653 stem cell donors
    Alexander H Schmidt
    DKMS German Bone Marrow Donor Center, Tubingen, Germany
    Hum Immunol 72:558-65. 2011
    ..3 million additional German donors...
  75. pmc HLA-G: a human pregnancy-related immunomodulator
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, United States
    Curr Opin Pharmacol 9:462-9. 2009
    ....
  76. ncbi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  77. ncbi Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment
    A H Schmidt
    DKMS German Bone Marrow Donor Center, Tubingen, Germany
    Tissue Antigens 76:362-79. 2010
    ..most favorable characteristics with respect to haplotypic and phenotypic diversity and the occurrence of rare HLA antigens. The opposite behavior is shown by regions 2-4 of the northwestern cluster...
  78. ncbi Predicting peptide binding to Major Histocompatibility Complex molecules
    Webber W P Liao
    Discipline of Medicine, Central Clinical School, University of Sydney, NSW, 2006, Australia
    Autoimmun Rev 10:469-73. 2011
    ..This review provides an overview of current methods for predicting peptide binding to the MHC, with a focus on structure-based methods, and explores the potential for future development in this area...
  79. ncbi New tools to monitor the impact of viral infection on the alloreactive T-cell repertoire
    L J D'Orsogna
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Tissue Antigens 74:290-7. 2009
    ..This technique may have important implications for donor selection and monitoring of transplant recipients...
  80. ncbi High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism
    Takakazu Kawase
    Division of Immunology, Aichi Cancer Center, Nagoya, Japan
    Blood 110:2235-41. 2007
    ..Furthermore, the identification of high-risk mismatch, that is, nonpermissive mismatch, would be beneficial for the selection of a suitable donor...
  81. pmc Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity
    Simone A Joosten
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 6:e1000782. 2010
    ..Our results significantly increase our understanding of the human immune response to Mtb by identification of CD8(+) T-cell responses to novel HLA-E binding peptides of Mtb, which have cytotoxic as well as immunoregulatory activity...
  82. ncbi Estimating unbiased haplotype frequencies from stem cell donor samples typed at heterogeneous resolutions: a practical study based on over 1 million German donors
    H P Eberhard
    ZKRD Zentrales Knochenmarkspender Register für Deutschland, German National Bone Marrow Donor Registry, Ulm, Germany
    Tissue Antigens 76:352-61. 2010
    ..We discuss algorithmic aspects of this approach and, also because of the sample size, provide some new insights into the distribution of HLA-DRB1 alleles in the German population and the application of HFs in unrelated donor search...
  83. ncbi The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress
    Thorbald van Hall
    Department of Clinical Oncology, Leiden University Medical Center, K1 P, Albinusdreef 2, 2333 ZA Leiden, Netherlands
    Microbes Infect 12:910-8. 2010
    ..Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects...
  84. ncbi HLA-G gene polymorphism in human placentas: possible association of G*0106 allele with preeclampsia and miscarriage
    Philippe Moreau
    Commissariat a l Energie Atomique, IBM, Service de Recherches en Hemato Immunologie, IUH, Hopital Saint Louis, 75475 Paris, France
    Biol Reprod 79:459-67. 2008
    ..The results suggest that the G*0106 allele, which is coupled with the presence of the 14-bp sequence, contributes and/or is a relevant marker in some specific complications of pregnancy, especially preeclampsia...
  85. ncbi Association between HLA-G 3'UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children
    Annalisa Fabris
    Genetic Service, IRCCS Burlo Garofolo, Trieste, Italy
    AIDS 23:177-82. 2009
    ..The aim of our study was to verify the possible association between an HLA-G 14-bp deletion/insertion polymorphism and perinatal HIV transmission in Brazilian children...
  86. ncbi Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome
    T V F Hviid
    Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark
    Tissue Antigens 64:66-9. 2004
    ..This might affect a possible immunomodulatory role of HLA-G expression in both the mother and foetus during implantation and pregnancy...
  87. ncbi A cryptic vascular endothelial growth factor T-cell epitope: identification and characterization by mass spectrometry and T-cell assays
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    Cancer Res 68:2447-54. 2008
    ..In the future, T cells directed against VEGF as a tumor-associated antigen may represent a possible way of combining peptide-based anti-VEGF immunotherapy with already existent anti-VEGF cancer therapies...
  88. ncbi HLA-G and MIC expression in tumors and their role in anti-tumor immunity
    Barbara Seliger
    Johannes Gutenberg University, IIIrd Department of Internal Medicine, Johannes Gutenberg Universitat, Langenbeckstr 1D 55101 Mainz, Germany
    Trends Immunol 24:82-7. 2003
    ..Available data suggest that the balance between activating and suppressing signals significantly influences the efficacy of the immune response and consequently of tumor progression...
  89. ncbi HLA class I antigen expression is associated with a favorable prognosis in early stage non-small cell lung cancer
    Eiki Kikuchi
    First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kitaku, Sapporo 060 8638, Japan
    Cancer Sci 98:1424-30. 2007
    ..These results suggest that down-regulation of HLA class I expression in NSCLC is a marker of poor prognosis, and this may play a critical role in immune surveillance of patients with NSCLC...
  90. ncbi HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives
    J A Hollenbach
    Department of Integrative Biology, University of California, Berkeley 94720, USA
    Hum Immunol 62:378-90. 2001
    ..These relationships are maintained in general across the entire HLA region in the Oaxacan Amerindians, with the exception of DPB1...
  91. ncbi Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
    Cheng Quan
    Department of Dermatology, No 2 Hospital, Anhui Medical University, Hefei, Anhui, China
    Nat Genet 42:614-8. 2010
    ..We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo...
  92. pmc Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanoma
    Paul F Robbins
    Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B42, Bethesda, MD 20892 7502, USA
    J Immunol 169:6036-47. 2002
    ..These observations provide an impetus to develop strategies directed toward generating HLA class II-restricted tumor-reactive T cells...
  93. ncbi Limits of HLA mismatching in unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, D4 100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 104:2976-80. 2004
    ..Whenever possible, HLA-C mismatches should be avoided for patients with early stage CML, and HLA-DQB1 mismatches should be avoided for patients with multiple mismatches...
  94. ncbi Celiac disease: from pathogenesis to novel therapies
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 137:1912-33. 2009
    ..These and other experimental therapies will be discussed critically...
  95. ncbi Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
    ..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
  96. ncbi Molecular mechanisms of HLA association with autoimmune diseases
    S Caillat-Zucman
    Institut National de la Sante et de la Recherche Medicale INSERM, U561, Hopital St Vincent de Paul, Paris, France
    Tissue Antigens 73:1-8. 2009
    ..Such analyses have significant interest in clinical practice to identify at-risk individuals and elaborate new therapeutic strategies aiming at inhibiting or preventing the autoimmune process...
  97. ncbi Tolerance versus immune response -- microRNAs as important elements in the regulation of the HLA-G gene expression
    T D Veit
    Genetics Department, Post Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Transpl Immunol 20:229-31. 2009
    ....
  98. pmc Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition
    Julia K Archbold
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Exp Med 206:209-19. 2009
    ..Accordingly, major histocompatibility complex (MHC) polymorphism can alter the dynamics of the peptide-MHC landscape, resulting in fine-tuning of T cell responses between closely related allotypes...
  99. ncbi Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B
    M C Eike
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Genes Immun 10:56-67. 2009
    ..On account of the unusual genetic complexity of the MHC, further fine mapping is demanded, with the possible exception of HLA-B. However, our results mean that these efforts can be focused on narrow, defined regions of the MHC...
  100. ncbi A critical look at HLA-G
    Richard Apps
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Trends Immunol 29:313-21. 2008
    ..These findings suggest how a fetal molecule might influence the local maternal immune response...
  101. ncbi Immune response genes in uveitis
    Liping Du
    Chongqing Key Laboratory of Ophthalmology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, PR China
    Ocul Immunol Inflamm 17:249-56. 2009
    ..Further developments in the unraveling of immune response genes may lead to a better understanding of human uveitis and will hopefully allow the development of novel treatment regimes...

Research Grants64

  1. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2013
    ..of how trafficking differences between HLA-B allotypes impact their antigen presenting ability will be important for better elucidating the effects of different HLA antigens on disease susceptibility, resolution, and progression.
  2. Improvement in Paired Donation Program
    Stanislaw M Stepkowski; Fiscal Year: 2013
    ..Instead, we need to adapt an assay allowing using donor lymphocyte extracts wherein donor HLA antigens are captured onto beads (Bead-HLA assay)...
  3. Adoptive Transfer of AlloCTL for Immunotherapy of Recurrent Gliomas
    Linda M Liau; Fiscal Year: 2013
    ..b>HLA antigens expressed on the patient's lymphocytes are also on brain tumor cells but not on normal brain cells such as ..
  4. Improving Kidney Transplant Outcomes Using Novel B-cell Immune Profiling
    Julie M Yabu; Fiscal Year: 2013
    ..2: To characterize the antigen specificity and intracellular signaling networks of B-cells that recognize HLA antigens in patients undergoing desensitization using CyTOF(R) mass spectrometry and MHC- peptide tetramer technology;..
  5. PREECLAMPSIA LINKAGE TO PLACENTAL IMPLANTATION-PERFUSION
    Robert Taylor; Fiscal Year: 1992
    ..of early human trophoblast with extracellular matrix in vitro and examine the expression and regulation of HLA antigens in trophoblast...
  6. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..local release of soluble forms of donor HLA antigen in lung transplant patients, determine which soluble donor HLA antigens can trigger regulation of DTH, and analyze the role of metalloproteinase therein; and 3) monitor the ..
  7. Maternal-Fetal HLA Sharing and Risk of Preeclampsia
    Audrey Saftlas; Fiscal Year: 2004
    ..a case-control study to determine if nulliparous women who develop preeclampsia are more likely to share HLA antigens with their infants than women who have normotensive gestations...
  8. MOLECULAR BIOLOGY OF DIABETOGENIC HAPLOTYPES DIABETES
    David Owerbach; Fiscal Year: 1991
    ..DNA from lymphoblastoid lines of 65 Caucasian families with about 400 members completely typed for HLA antigens, A, B, C, and DR, complement BF, C2 and C4 alleles and glyoxylase I alleles will be typed using cDNA and ..
  9. MOLECULAR GENETICS OF CONGENITAL ADRENAL HYPERPLASIA
    Perrin White; Fiscal Year: 1993
    ..the HLA major histocompatibility complex, and different mutations appear to be associated with characteristic HLA antigens. Such mutations will be defined by producing genomic libraries using DNA from patients with 21-OHase deficiency ..
  10. HLA ANTIGENS: POLYMORPHISMS AND APPLICATIONS
    FRANK GRUMET; Fiscal Year: 1980
    ..Because further characterization of HLA antigens, especially the new B cell alloantigens, may provide better genetic markers for human IR or disease ..
  11. ROLE OF HLA-B27 AND SHIGELLA ANTIGENS IN DISEASE
    John Shively; Fiscal Year: 1980
    ..The specificity and nature of this abnormal response will be further delineated by inhibition with antisera specific for bacterial and HLA antigens produced in this laboratory.
  12. TLI IN RENAL TRANSPLANTATION
    Samuel Strober; Fiscal Year: 1990
    ..In addition, we will try to identify the specific Class II HLA antigens to which unresponsiveness is directed so that purified forms of this material may be used in the latter ..
  13. ISOLATION OF HUMAN FETAL CELLS FROM MATERNAL BLOOD
    James Leary; Fiscal Year: 1992
    ..001 percent) fetal cells directly from maternal blood on the basis of monoclonal antibodies against paternal HLA antigens, against fetal trophoblastic antigens, or against selected proto- oncogene products elevated in fetal cells...
  14. CLASS II HLA ANTIGENS IN THE AQUEOUS OUTFLOW SYSTEM
    Mary Lynch; Fiscal Year: 1992
    ..We will refine our experimental model of glaucoma in the mouse and rat eye and use this model to explore the importance of aqueous drainage to the development of ACAID...
  15. Immune function in desensitized allograft recipients
    Jonathan Schneck; Fiscal Year: 2005
    ..We have observed that PP/CMVIg durably eliminates antibody to donor HLA while antibodies to third party HLA antigens often recur or expand following the cessation of treatment...
  16. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..Although donor blood and recipient have been matched for blood group antigens, they are not routinely typed for HLA antigens. Thus in almost all cases, the transfusion results in the introduction of alloantigens to the recipients...
  17. HLA CLASS I PRESENTATION OF HIV PEPTIDES
    Margaret Smith; Fiscal Year: 1999
    DESCRIPTION: (Adapted from investigator's abstract) Class I HLA antigens present an array of peptides for recognition by cytotoxic T lymphocytes (CTL)...
  18. GENETIC CHILDHOOD DISEASES AND AGING
    H Fudenberg; Fiscal Year: 1980
    ..immunological diseases, some known to be genetically determined and some of unknown causes, are linked to HLA antigens. We also propose to use immunologic means to study the genetic mechanisms operative in genetic diseases of ..
  19. HLA REGULATION IN NORMAL AND PREECLAMPTIC TROPHOBLASTS
    Elliott Main; Fiscal Year: 1992
    ..Expression and recognition of HLA antigens are critical for cell-cell interactions such as these...
  20. HLAMatchmaker for Transplantation and Transfusion
    Rene Duquesnoy; Fiscal Year: 2007
    ..For many patients, HLAMatchmaker can identify mismatched HLA antigens that are zero-triplet mismatches and should therefore, be considered fully histocompatible at the structural ..
  21. ANTIVASCULAR ENDOTHELIAL ANTIBODY--ORGAN TRANSPLANTATION
    G Cerilli; Fiscal Year: 1992
    ..Risk factors in transplantation, VEC typing, the development of posttransplant sensitization to VEC and HLA antigens and graft outcome will be subjected to multivariant analysis...
  22. ACQUISITION OF IMMUNITY TO MALARIA IN CAMEROON
    Diane Taylor; Fiscal Year: 1999
    ..may lead to altered fetal development, including levels of tumor necrosis factor (TNF), aberrant expression of HLA antigens on syncytiotrophoblasts, and strains of parasites that differ in virulence...
  23. BIOCHEMICAL RELATIONSHIP OF PLATELET AND PLASMA HLA
    K Kao; Fiscal Year: 1993
    ..alloimmunized patients with platelets from donors who have a low expression of one or two mismatched HLA antigens. It can also be used to compare the variable expression of specific HLA between platelets and lymphocytes, to ..
  24. NEUTROPHIL ANTIGENS IN IMMUNE NEUTROPENIA
    Wade Smith; Fiscal Year: 1980
    ..The antigens involved are frequently not identifiable as known red cell, neutrophil or HLA antigens. We will study human neutrophil antigens to detect new antigenic specificities, determine their inheritance in ..
  25. MONITORING IG-SECRETING CELLS
    Giuseppe Molinaro; Fiscal Year: 1980
    ..is to show that the old and patients with auto-immune diseases have lymphocytes which are reactive with self HLA antigens and which play a pathogenic role...
  26. TRANSFUSION TRIAL TO PREVENT PLATELET ALLOIMMUNIZATIONS
    Wendell Rosse; Fiscal Year: 1992
    ..selection of platelet donors by matching HLA antigens, particularly the so-called "public" antigens; 2. removal of leukocytes from platelet products by filtration...
  27. TRAINING IN CLINICAL IMMUNOLOGY
    Dennis Carson; Fiscal Year: 2000
    ..The program emphasizes the following areas: (1) the relationship between HLA antigens and rheumatoid arthritis; (2) molecular basis of autoantibody production; (3) mechanisms of joint and cartilage ..
  28. HLA CLASS II GENES; REGULATION OF EXPRESSION
    Janet Lee; Fiscal Year: 1992
    The major histocompatibility complex (MHC) antigens, HLA antigens in man, are of fundamental importance in generating, regulating, and effecting an immune response to foreign antigens...
  29. GENETICS OF RESISTANCE TO LEUKEMIA
    Daniel Meruelo; Fiscal Year: 2002
    ..The under-representation of HLA antigens in human tumors is usually associated with a poor prognosis...
  30. Biomagnetic Determinantion of Transplant Rejection
    Edward Flynn; Fiscal Year: 2005
    ..rejection occurs through several mechanisms, but is dominated by multiplication of T cells which attach to HLA antigens on the donor cells and kill them...
  31. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 2007
    ..abstract_text> ..
  32. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  33. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  34. Immune Parameters in a Steroid Sparing Clinical Trial
    Nancy Reinsmoen; Fiscal Year: 2005
    ..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..
  35. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..It could lead to novel therapeutic approaches in a wide range of disorders including infertility, miscarriage, disorders due to defective placentation (pre-eclampsia and IUGR) and menstrual disorders. ..
  36. Mentored Patient-Oriented Research Career Development Aw
    David Rizzieri; Fiscal Year: 2004
    ..These results will lead to future improvements in maximizing the anti-tumor effects of allogeneic therapy, hastening immunologic recovery, and minimizing the toxicity of this procedure. ..
  37. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  38. Identification of Measles Class II-Restricted Peptides
    INNA OVSYANNIKOVA; Fiscal Year: 2003
    ..The basis from which this proposal will build on is outlined in the background, significance, and preliminary data sections below. ..
  39. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  40. Regulation of the baboon HLA-G-like class Ib MHC gene, Paan-AG
    DAUDI LANGAT; Fiscal Year: 2008
    ..Thus the baboon is clearly an excellent model for HLA-G functional experiments, and testing the therapeutic applications of HLA-G in human pregnancy and transplantation. [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  42. 14th International HLA & Immunogenetics Workship (HIWS)
    John Hansen; Fiscal Year: 2005
    ..The scientific exchange that will take place at the meeting will drive research and maintain international collaboration in immunogenetics for the next 5 years. ..
  43. Restoring T Cell Responses to Therapeutic Tumor Vaccines
    Ephraim Fuchs; Fiscal Year: 2009
    ....
  44. Multi-peptide Vaccine Administered with Cyclophosphamide for High-risk Melanoma
    CRAIG LEE SLINGLUFF; Fiscal Year: 2010
    ....
  45. Whole Genome Association Analysis of Hematopoietic Cell Transplant Outcome
    John Hansen; Fiscal Year: 2008
    ..The third stage will explore genome-genome interactions between recipient and donor. [unreadable] [unreadable] [unreadable]..
  46. Enhancing Doctor-Patient Communication
    Stephanie Lee; Fiscal Year: 2006
    ..The project works towards the overall goal of enhancing communication, improving patient understanding, and facilitating psychosocial adaptation to life-threatening illness. ..
  47. PROTEIN PAINTING OF PREIMPLANTATION EMBRYOS
    Carol Warner; Fiscal Year: 2003
    ..Protein painting may ultimately be applied to create better conditions for modulating preimplantation embryonic growth or death, leading to enhanced pregnancy outcome or a new contraceptive technology. ..
  48. Tolerated xenografts using virus stealth technology
    MARK CREW; Fiscal Year: 2003
    ..Moreover, the proposed exploitation of viral stealth technology could be readily adopted for allotransplants especially those involving allogeneic stem cells. ..
  49. SCLERODERMA LUNG STUDY
    Maureen Mayes; Fiscal Year: 2003
    ..abstract_text> ..
  50. MULTI-EPITOPE MELANOMA PEPTIDE VACCINATION WITH GM-CSF
    Craig Slingluff; Fiscal Year: 2004
    ..abstract_text> ..
  51. VACCINES WITH MHC CLASS II-RESTRICTED MELANOMA PEPTIDES
    Craig Slingluff; Fiscal Year: 2004
    ....
  52. PED GENE ACTION IN DEVELOPMENT AND REPRODUCTION
    Carol Warner; Fiscal Year: 2005
    ..This hypothesis will be tested in the third specific aim by using an HLA-G transgenic mouse system. ..
  53. Genetic/Immunological Basis of Tuberculosis and Anergy
    Julio Delgado; Fiscal Year: 2005
    ..It is anticipated that these results will be useful in the development of genetic and immune therapeutic strategies to combat tuberculosis. ..
  54. Exploiting porcine cytomegalovirus stealth mechanisms
    MARK CREW; Fiscal Year: 2005
    ..The Phase I project will be deemed successful when we have identified specific genes from PCMV which impart stealth to pig cells in vitro when exposed to cells from the human immune system. ..
  55. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  56. CYTOTOXIC T LYMPHOCYTE RESPONSE TO HPV 16
    Mayumi Nakagawa; Fiscal Year: 2002
    ....