hla dr antigens

Summary

Summary: A group of D-related human leukocyte antigens that are polymorphic glycoproteins found on lymphoid cells. They consist of alpha and beta chains and their inheritance differs from that of the DQ and DP antigens; their presence seems to be associated with certain skin diseases like pemphigus vulgaris, dermatitis herpetiformis, and type I diabetes.

Top Publications

  1. ncbi Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis
    M G Marrosu
    Multiple Sclerosis Center, University of Cagliari, Italy
    Neurology 63:1084-6. 2004
  2. ncbi ProPred: prediction of HLA-DR binding sites
    H Singh
    Bioinformatics Centre, Institute of Microbial Technology, Sector 39A, Chandigarh-160036, India
    Bioinformatics 17:1236-7. 2001
  3. pmc HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis
    K Ito
    Department of Inflammation and Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, New Jersey 07110, USA
    J Exp Med 183:2635-44. 1996
  4. pmc HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis
    Boel Brynedal
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 2:e664. 2007
  5. pmc MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation
    Aude de Gassart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 105:3491-6. 2008
  6. ncbi CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
    G W Beresford
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 2:652-7. 2001
  7. ncbi Risk alleles for multiple sclerosis identified by a genomewide study
    David A Hafler
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 357:851-62. 2007
  8. ncbi Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2113-21. 2004
  9. pmc Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms
    Manuel Comabella
    Unitat de Neuroimmunologia Clinica, CEM Cat, Hospital Universitari Vall d Hebron, Barcelona, Spain
    PLoS ONE 3:e3490. 2008
  10. ncbi Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population
    S Saito
    Nagano Red Cross Blood Center, Nagano, Japan
    Tissue Antigens 56:522-9. 2000

Detail Information

Publications358 found, 100 shown here

  1. ncbi Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis
    M G Marrosu
    Multiple Sclerosis Center, University of Cagliari, Italy
    Neurology 63:1084-6. 2004
    ..Parental transmission of DR3 and DR4, assessed in a set of 565 case-parent triads, showed evidence of paternal inheritance of DR3 in affected women, thus explaining the excess of females in the DR3 category...
  2. ncbi ProPred: prediction of HLA-DR binding sites
    H Singh
    Bioinformatics Centre, Institute of Microbial Technology, Sector 39A, Chandigarh-160036, India
    Bioinformatics 17:1236-7. 2001
    ..AVAILABILITY: The server is available at http://www.imtech.res.in/raghava/propred/ CONTACT: raghava@imtech.res.in SUPPLEMENTARY INFORMATION: http://www.imtech.res.in/raghava/propred/page3.html..
  3. pmc HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis
    K Ito
    Department of Inflammation and Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, New Jersey 07110, USA
    J Exp Med 183:2635-44. 1996
    ..Non-Tg mice immunized with either PLP175-192 or MBP87-106 did not develop EAE. These results demonstrated that a human MHC class II binding site alone can confer susceptibility to an experimentally induced murine autoimmune disease...
  4. pmc HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis
    Boel Brynedal
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 2:e664. 2007
    ..These findings imply complex autoimmune mechanisms involving both the regulatory and the effector arms of the immune system in the triggering of MS...
  5. pmc MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation
    Aude de Gassart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 105:3491-6. 2008
    ..MARCH I is, therefore, a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs...
  6. ncbi CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
    G W Beresford
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 2:652-7. 2001
    ..H4 acetylation was mapped to Lys8, which implicated several histone acetyltransferases as possible modulators of this activity...
  7. ncbi Risk alleles for multiple sclerosis identified by a genomewide study
    David A Hafler
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 357:851-62. 2007
    ..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis...
  8. ncbi Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2113-21. 2004
    ..We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides (anti-CCP antibodies)...
  9. pmc Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms
    Manuel Comabella
    Unitat de Neuroimmunologia Clinica, CEM Cat, Hospital Universitari Vall d Hebron, Barcelona, Spain
    PLoS ONE 3:e3490. 2008
    ..This region of chromosome 13 has not been previously identified in MS linkage genome screens and represents a novel risk locus for the disease...
  10. ncbi Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population
    S Saito
    Nagano Red Cross Blood Center, Nagano, Japan
    Tissue Antigens 56:522-9. 2000
    ....
  11. ncbi Evolutionary stability of MHC class II haplotypes in diverse rhesus macaque populations
    Gaby G M Doxiadis
    Department of Comparative Genetics and Refinement and Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Immunogenetics 55:540-51. 2003
    ..Furthermore, novel haplotypes are generated by recombination-like events. The results imply that mtDNA analysis in combination with Mhc typing is a helpful tool for selecting animals for biomedical experiments...
  12. ncbi MHC class II expression identifies functionally distinct human regulatory T cells
    Clare Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4622-31. 2006
    ..Thus, the direct ex vivo expression of MHC-II in the context of CD25(high) identifies a mature, functionally distinct regulatory T cell population involved in contact-dependent in vitro suppression...
  13. ncbi A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
    F Cucca
    Dipartimento di Scienze Biomediche e Biotecnologie, University of Cagliari, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 10:2025-37. 2001
    ..Overall, these results suggest shared epitope(s) in the target autoantigen(s), and common pathways in human and murine T1D...
  14. ncbi Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection
    Andreas Hug
    Department of Neurology, University of Heidelberg, University Hospital Heidelberg, Germany
    Stroke 40:3226-32. 2009
    ..Hallmarks of this stroke-induced immunodepression syndrome are: lymphocytopenia, impairment of T helper cell and monocyte function. We studied which stroke-specific factors predict these immunologic alterations and subsequent infections...
  15. ncbi Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:2547-54. 2006
    ..To determine whether patients with Vogt-Koyanagi-Harada (VKH) disease have immune responses specific to the melanocyte antigens tyrosinase and gp100...
  16. pmc HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
    Henry Erlich
    Roche Molecular Systems, 1145 Atlantic Ave, Alameda, CA 94501, USA
    Diabetes 57:1084-92. 2008
    ..The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes...
  17. pmc Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease
    A P Fontenot
    Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:12717-22. 2000
    ..Based on amino acid residues shared by these restricting and susceptibility DP alleles, our results provide insight into the residues of the DP beta-chain required for beryllium presentation...
  18. ncbi The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF
    Kai Uwe Belge
    Institute for Immunology, University of Muenchen, Germany
    J Immunol 168:3536-42. 2002
    ..This indicates that the minor population of CD14(+)CD16(+) monocytes are major producers of TNF in human blood...
  19. ncbi Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population
    K W Lee
    Hallym Institution for Genome Application, Hallym University, Sacred Heart Hospital, 896 Pyungchon Dong, Dongan Ku, Anyang, Kyungki Do 431 070, Korea
    Tissue Antigens 65:437-47. 2005
    ..Information obtained in this study will be useful for medical and forensic applications as well as in anthropology...
  20. pmc Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Hum Genet 76:561-71. 2005
    ..DNA and clinical data for the MADGC families are available to the scientific community; these data will provide a valuable resource for the dissection of the complex genetic factors that underlie the various autoimmune phenotypes...
  21. ncbi A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity
    Pierre Antoine Gourraud
    INSERM U558, Toulouse, France
    Arthritis Rheum 54:593-9. 2006
    ..We investigated the relevance of this classification in terms of the structural severity of RA...
  22. ncbi HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination
    Nancy A Danke
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Immunol 171:3163-9. 2003
    ....
  23. ncbi In primary Sjögren's syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response
    Jacques Eric Gottenberg
    Service de Rhumatologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris AP HP, INSERM EMI 0109, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Arthritis Rheum 48:2240-5. 2003
    ..To reevaluate, in a large series of patients with Sjögren's syndrome (SS) recruited from 2 French centers, the question of whether HLA is associated with SS itself or with a pattern of secretion of autoantibodies...
  24. pmc Extreme genetic risk for type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:14074-9. 2006
    ..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity...
  25. pmc Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
    S P Linn-Rasker
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 65:366-71. 2006
    ..To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis...
  26. ncbi The association of the HLA class II antigens with clinical and autoantibody expression in Malaysian Chinese patients with systemic lupus erythematosus
    M R Azizah
    Biotechnology Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
    Asian Pac J Allergy Immunol 19:93-100. 2001
    ..From these data we suggest that the HLA class II genes play a role in conferring disease susceptibility and clinical and immunological expression...
  27. pmc Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells
    Michaela Lucas
    Nuffield Department of Medicine, University of Oxford, United Kingdom
    J Virol 78:7284-7. 2004
    ..These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct "central memory" CD62L(+) phenotype...
  28. ncbi Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis
    Angelica M Delgado-Vega
    Unidad de Biología Celular e Inmunogenética, Corporacion para Investigaciones Biologicas, Medellin, Colombia School of Medicine, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 6:402-8. 2007
    ..To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data...
  29. ncbi Genetics of rheumatoid arthritis: underlying evidence of ethnic differences
    Yuta Kochi
    University of Tokyo Hospital, Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    J Autoimmun 32:158-62. 2009
    ....
  30. ncbi A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
    ..To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins...
  31. ncbi Characteristics of Type 1 diabetes of over 50 years duration (the Golden Years Cohort)
    S C Bain
    Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Diabet Med 20:808-11. 2003
    ..Type 1 diabetes mellitus is associated with high levels of premature morbidity and mortality. Prolonged survival is possible, however, and some patients appear to be protected from the long-term complications of this condition...
  32. pmc Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression
    Eleni Zika
    Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:16321-6. 2005
    ..These results suggest functional and temporal relationships among CIITA, CARM1, and CBP for IFN-gamma induction of MHC-II...
  33. pmc HLA-DRB1 among patients with Vogt-Koyanagi-Harada disease in Saudi Arabia
    Alia Iqniebi
    Histocompatibility and Immunogenetics Research Unit, Stem Cell Therapy Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mol Vis 15:1876-80. 2009
    ..So, the purpose of this study was to investigate the association of human leukocyte antigen (HLA)-DRB1 alleles to VKH patients and to clarify the molecular genetic mechanism underlying the susceptibility or resistance to VKH disease...
  34. ncbi Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival
    C M Ohri
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    Eur Respir J 33:118-26. 2009
    ..The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity...
  35. pmc Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK
    Nature 450:887-92. 2007
    ..Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes...
  36. pmc Phenotypic characterization of five dendritic cell subsets in human tonsils
    K L Summers
    Hematology/Immunology Research Group, Christchurch Hospital, Christchurch, New Zealand
    Am J Pathol 159:285-95. 2001
    ..The definition and extensive phenotypic analysis of these five DC subsets in human tonsil extends our understanding of the complexity of DC biology...
  37. ncbi Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population
    Ann W Morgan
    Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St James University Hospital, Leeds, UK
    Arthritis Rheum 60:2565-76. 2009
    ..To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA)...
  38. ncbi New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans
    W Klitz
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 62:296-307. 2003
    ..Four DQA1-DQB1 haplotypes, all rare, are reported here for the first time. The haplotype frequency tables are suitable as a reference standard for HLA typing of the DR and DQ loci in European Americans...
  39. ncbi Dimorphic histopathology of long-standing childhood-onset diabetes
    R Gianani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, Aurora, CO 80055, USA
    Diabetologia 53:690-8. 2010
    ..The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity...
  40. ncbi Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes 53:2684-90. 2004
    ....
  41. ncbi CD14+CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies
    J Skrzeczynska
    Department of Immunology, Institute of Molecular Biology, Jagiellonian University, Medical College, Cracow, Poland
    Scand J Immunol 55:629-38. 2002
    ..The reduced interleukin (IL)-1 but rather increased IL-10 production was associated with sepsis. The differences between CD14+CD16+ monocytes of healthy donors and patients with sepsis are discussed...
  42. pmc Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections
    A Lekkou
    Department of Internal Medicine, Patras University Hospital, School of Medicine, 26500 Patras, Greece
    Clin Diagn Lab Immunol 11:161-7. 2004
    ..Monocyte HLA-DR expression is an early and constant predictive marker for survival in severe sepsis, while serum IL-10 levels on days 3 and 10 have negative prognostic value for the final outcome...
  43. pmc An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus
    G C DeLuca
    Department of Clinical Neurology, and Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 104:20896-901. 2007
    ..These results closely link susceptibility to long-term outcome in MS, suggesting that shared quantitative MHC-based mechanisms are common to both, emphasizing the central role of this region in pathogenesis...
  44. pmc Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development
    Anouk L Feitsma
    Departments of Immunohematology and Blood Transfusion and Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 104:19966-70. 2007
    ..25; P = 0.003). These data show a protective NIMA-effect in a human autoimmune disease and indicate that a DERAA-positive mother can transfer protection against RA to her DERAA-negative child...
  45. ncbi Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Diabetes 55:1862-8. 2006
    ....
  46. ncbi HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China
    E Trachtenberg
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 70:455-63. 2007
    ....
  47. ncbi T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and -negative Vogt-Koyanagi-Harada uveitis
    Francisco Max Damico
    Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Invest Ophthalmol Vis Sci 46:2465-71. 2005
    ..This study was undertaken to analyze T-cell recognition and the cytokine expression profile induced by melanocyte epitopes in HLA-DRB1*0405-positive and -negative patients with VKH uveitis...
  48. pmc HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course
    L F Barcellos
    Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Am J Hum Genet 72:710-6. 2003
    ..Concepts of the molecular mechanisms that underlie linkage and association of the human leukocyte antigen (HLA) region to MS need to be revised to accommodate these data...
  49. ncbi DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California
    Sleep 17:S60-7. 1994
    ..These results demonstrate that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups...
  50. ncbi Prognostic markers of radiographic progression in early rheumatoid arthritis
    Jorg J Goronzy
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 50:43-54. 2004
    ..To identify prognostic markers that are predictive of progressive erosive disease in patients with early rheumatoid arthritis (RA)...
  51. ncbi Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production
    A Spittler
    Department of Surgery, Research Laboratories, University of Vienna, Vienna, Austria
    Clin Infect Dis 31:1338-42. 2000
    ..Our data indicate that IL-6 levels are a better prognostic parameter in the early phase of sepsis than the monocyte HLA-DR expression...
  52. ncbi IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity
    M Walter
    Diabetes Research Institute, Munich Schwabing Hospital, Kolner Platz 1, 80804 Munich, Germany
    Diabetologia 46:712-20. 2003
    ..The aim of this study was to determine whether combining IDDM1/HLA and IDDM2/ insulin( INS) 5' variable number of tandem repeat locus (VNTR) genotypes improves T1D risk assessment...
  53. ncbi A functional and structural basis for TCR cross-reactivity in multiple sclerosis
    Heather L E Lang
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Nat Immunol 3:940-3. 2002
    ..This provides structural evidence for molecular mimicry involving HLA molecules. The structural details suggest an explanation for the preponderance of MHC class II associations in HLA-associated diseases...
  54. ncbi Visual manifestations of giant cell arteritis. Trends and clinical spectrum in 161 patients
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 79:283-92. 2000
    ..The presence of other ischemic complications constitutes an alarm for the development of irreversible blindness. In contrast, a higher inflammatory response may be a protective factor against the development of cranial ischemic events...
  55. pmc A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
    Yuta Kochi
    Laboratory for Rheumatic Diseases, SNP Research Center, RIKEN, Yokohama 230 0045, Japan
    Nat Genet 37:478-85. 2005
    ..We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity...
  56. pmc An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene
    Sreeram V Ramagopalan
    1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:10. 2009
    ..Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk...
  57. pmc Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP)
    K Forslind
    Section of Rheumatology, Helsingborgs Iasarett, Helsingborg, Sweden
    Ann Rheum Dis 63:1090-5. 2004
    ..To investigate the role of anti-cyclic citrullinated peptide antibody (anti-CCP) for the prediction of radiological outcome in patients with early rheumatoid arthritis...
  58. ncbi Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
    Lisa F Barcellos
    Division of Epidemiology, School of Public Health, University of California, Berkeley 94720, USA, and Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, UK
    Hum Mol Genet 15:2813-24. 2006
    ....
  59. pmc Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates
    U B Gyllensten
    Department of Medical Genetics, University of Uppsala, Sweden
    Proc Natl Acad Sci U S A 88:3686-90. 1991
    ..Allelic polymorphism at the DRB1 locus may thus have been generated in part by combining different variants of the two structural domains...
  60. pmc Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression
    J Rodel
    Institute of Medical Microbiology, Friedrich Schiller University of Jena, D 07743 Jena, Germany
    Infect Immun 66:4491-5. 1998
    ..Chlamydial infection inhibited IFN-gamma-induced expression of HLA-DR antigen in the cells. Addition of IFN-beta antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-beta...
  61. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
    ..Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy...
  62. ncbi Monocytes are major players in the prognosis and risk of infection after acute stroke
    Xabier Urra
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    Stroke 40:1262-8. 2009
    ..Monocyte numbers increase in patients with stroke associated infection (SAI) or severe stroke. Whether changes in monocytes are related to specific effects, or simply mark brain damage, remains unsettled...
  63. pmc Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1400, USA
    J Clin Invest 100:339-49. 1997
    ..This study provides new insight about MBP recognition and proposes an alternative mechanism for immunodominance of self-antigen T cell epitopes in humans...
  64. ncbi HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity
    J Renquin
    Laboratory of Genetics and Biometry LGB, Department of Anthropology and Ecology, University of Geneva, Geneva, Switzerland
    Tissue Antigens 58:211-22. 2001
    ....
  65. ncbi HLA class II associated risk and protection against multiple sclerosis-a Finnish family study
    Mikko Laaksonen
    Turku Immunology Centre and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN 20520, Turku, Finland
    J Neuroimmunol 122:140-5. 2002
    ..008) after the elimination of DRB1*15-DQB1*0602 haplotypes. Based on this study HLA class II haplotypes exhibit both predisposing and protective effects in MS...
  66. ncbi Study of Cynomolgus monkey (Macaca fascicularis) MhcDRB (Mafa-DRB) polymorphism in two populations
    Antoine Blancher
    Laboratoire d Immunogenetique moleculaire, Universite Paul Sabatier, Faculte de Medecine de Rangueil, Batiment A2, 133, route de Narbonne, 31062, Toulouse Cedex 4, France
    Immunogenetics 58:269-82. 2006
    ..Out of the 20 haplotypes that we defined here, only two were found in both populations. The functional impact of DR incompatibility was studied in vitro by mixed lymphocyte culture...
  67. pmc Ancient haplotypes of the HLA Class II region
    Christopher K Raymond
    University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Genome Res 15:1250-7. 2005
    ....
  68. ncbi The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  69. ncbi Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B
    Ye gui Jiang
    Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 9:2221-5. 2003
    ..To investigate the association between the polymorphism of HLA-DRB1, -DQA1 and -DQB1 alleles and viral hepatitis B...
  70. ncbi Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis
    G Orozco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Rheumatology (Oxford) 47:138-41. 2008
    ....
  71. ncbi An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections
    Malak Kotb
    Veterans Affairs Medical Center, Research Service, Memphis, Tennessee, USA
    Nat Med 8:1398-404. 2002
    ..We propose that human leukocyte antigen class II allelic variation contributes to differences in severity of invasive streptococcal infections through their ability to regulate cytokine responses triggered by streptococcal superantigens...
  72. pmc Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies
    T Cantaert
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Ann Rheum Dis 64:1316-20. 2005
    ..Haplotypes of PADI4, encoding for a citrullinating enzyme, were associated with rheumatoid arthritis in a Japanese population. It was suggested they were related to the presence of anticitrullinated protein antibodies (ACPA)...
  73. ncbi HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis
    D L Mattey
    Staffordshire Rheumatology Centre, Stoke on Trent, England, UK
    J Rheumatol 28:232-9. 2001
    ..To determine whether the association between rheumatoid arthritis (RA) and HLA-DRB1 is influenced by the amino acid residue encoded at position 70 (beta70) of the third hypervariable region (HVR3) of the HLA-DRbeta chain...
  74. ncbi Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles
    F E Haydardedeoglu
    Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey
    Tissue Antigens 68:293-6. 2006
    ..42, 95% CI 0.24-0.75). Data suggest that HLA-DRB1*07 allele may be a genetic factor in increasing the susceptibility to develop RHD and recurrent streptococcal pharyngitis. HLA-DRB1*11 allele seems to be a protective factor against RHD...
  75. pmc Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility
    Andreas Jönsen
    Department of Rheumatology, Lund University Hospital, Lund, Sweden
    Arthritis Res Ther 6:R557-62. 2004
    ..5-95.4). This study demonstrates that certain combinations of gene variants may increase susceptibility to SLE, suggesting this approach for future studies. It also confirms earlier findings regarding the HLA DR3-DQ2-C4AQ0 haplotype...
  76. ncbi Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease
    Lisa A Maier
    Department of Medicine, Hollis Laboratory of Occupational and Environmental Health, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:6910-8. 2003
    ..We conclude that DPB1 Glu69 is a marker of sensitization and not specific for disease. Glu(69) homozygosity acts as a functional marker associated with markers of CBD severity...
  77. ncbi African diversity from the HLA point of view: influence of genetic drift, geography, linguistics, and natural selection
    A Sanchez-Mazas
    Laboratory of Genetics and Biometry, Department of Anthropology and Ecology, University of Geneva, Geneva, Switzerland
    Hum Immunol 62:937-48. 2001
    ..However, this selective effect did not disrupt the high correlation found between DRB1 and geography at the world scale, nor between DRB1 and linguistic differentiations at the African level...
  78. ncbi Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 169:696-702. 2004
    ..The influence of HLA class I alleles on sarcoidosis thus seems more pronounced than previously thought, and both HLA class I and class II should be relevant to evaluate in the clinical management of sarcoidosis patients...
  79. pmc Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
    Daniel E Kaufmann
    Partners AIDS Research Center and Infectious Disease Unit, Howard Hughes Medical Institute, Massachusetts General Hospital, and Division of AIDS, Boston, Massachusetts 02114, USA
    J Virol 78:4463-77. 2004
    ..These findings have implications for the design of immunotherapeutic strategies and for testing candidate HIV vaccines...
  80. ncbi Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis
    Naoyuki Tsuchiya
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Rheumatol 30:1534-40. 2003
    ..Little is known on the genetic background of AAV in Japanese patients mainly because of the difficulty in collecting a sufficient number of samples for the genetics study...
  81. ncbi Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
    David A Dyment
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 14:2019-26. 2005
    ..These studies demonstrate that it is the Class II genotype that determines susceptibility and resistance to MS. By analogy with celiac disease and type I diabetes, the pattern of susceptibility strongly supports an autoimmune aetiology...
  82. pmc Strong HLA-DR expression in large bowel carcinomas is associated with good prognosis
    S N Andersen
    Institute of Forensic Medicine, National Hospital, University of Oslo, Norway
    Br J Cancer 68:80-5. 1993
    ..To our knowledge this is the first time a relationship between intensity of tumour DR expression and survival has been shown in large bowel carcinoma...
  83. pmc Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells
    E Fiebiger
    Division of Immunology, Allergy, and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 193:881-92. 2001
    ..Thus, the control of protease activity by pro- and antiinflammatory cytokines is an essential feature of the Ag presentation properties of DCs...
  84. ncbi Mononuclear histocompatibility leukocyte antigen-DR expression in the early phase of acute pancreatitis
    Wen kui Yu
    Department of General Surgery, School of Medince, Nanjing University, Nanjing, PR China
    Pancreatology 4:233-43. 2004
    ..We investigated the time course of HLA-DR expression in the early phase of AP and the relationship to markers of inflammation, severity of the disease, organ function, septic complications and outcome during AP...
  85. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
    ..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention...
  86. pmc MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus
    N J McHugh
    Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, Somerset BA1 1RL UK
    Ann Rheum Dis 65:488-94. 2006
    ..To conduct a case-control study to investigate whether there are independent tumour necrosis factor alpha (TNFalpha) or lymphotoxin alpha (LTalpha) haplotype associations with SLE or with any of the major serological subsets of SLE...
  87. ncbi FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study
    A W Morgan
    Rheumatology and Rehabilitation Research Unit, University of Leeds, UK
    Rheumatology (Oxford) 42:528-33. 2003
    ..To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA)...
  88. ncbi Reshuffling of ancient peptide binding motifs between HLA-DRB multigene family members: old wine served in new skins
    Gaby G M Doxiadis
    Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, Rijswijk, The Netherlands
    Mol Immunol 45:2743-51. 2008
    ..As no evidence was found for convergent evolution, the combination of these two observations indicates that ancient peptide binding motifs are frequently reshuffled among duplicated members of the HLA-DRB multigene family...
  89. ncbi Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins
    Anja Moldenhauer
    Institute for Transfusion Medicine and Immunehaematology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Leukoc Biol 76:623-33. 2004
    ..This model system suggests that the Hdi supports the in vitro differentiation of DC from leukemic blasts with AML1-containing fusion proteins...
  90. ncbi HLA-DRB1, DQB1, and DQA1 allele profile in Brazilian patients with type 1 diabetes mellitus
    A P M Fernandes
    Department of General and Specialized Nursing, School of Nursing of Ribeirao Preto, University of Sao Paulo, 14 049 902, Ribeirao Preto, Sao Paulo, Brazil
    Ann N Y Acad Sci 958:305-8. 2002
    ..In addition to HLA-DRB1*15 and DQB1*0602 alleles, DRB1*11, DRB1*13, and DQA1*01 allele groups were associated with protection against the development of type 1 diabetes in Brazilian patients...
  91. ncbi The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:425-32. 2007
    ....
  92. ncbi Major histocompatibility locus genetic markers of beryllium sensitization and disease
    C Saltini
    Division of Respiratory Diseases of the University of Rome Tor Vergata at the National Institute for Infectious Diseases, Spallanzani Hospital, Rome, Italy
    Eur Respir J 18:677-84. 2001
    ..5-10.1). The data indicate that tumour necrosis factor-alpha, human leukocyte antigen-DR and human leukocyte antigen-DP markers play different roles in beryllium sensitization and granuloma formation in beryllium-exposed workers...
  93. pmc Components of the ligand for a Ni++ reactive human T cell clone
    Linh Lu
    Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 197:567-74. 2003
    ..We propose a general model for Ni(2+) recognition in which betaHis81 and two amino acids from the NH(2)-terminal part of the MHC bound peptide coordinate Ni(2+) which then interacts with some portion of the Valpha CDR1 or CDR2 region...
  94. ncbi Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis
    Allen C Steere
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 48:534-40. 2003
    ..To assess the binding of outer surface protein A (OspA) and human lymphocyte function-associated antigen 1 (hLFA-1) peptides to 5 major histocompatibility complex (MHC) molecules...
  95. ncbi The origin of Minnan and Hakka, the so-called "Taiwanese", inferred by HLA study
    M Lin
    Transfusion Medicine Research Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
    Tissue Antigens 57:192-9. 2001
    ..These observations suggests that this haplotype is the most well-conserved ancient haplotype of the Yueh...
  96. ncbi Associations of MHC genes with levels of caries-inducing organisms and caries severity in African-American women
    R T Acton
    Department of Microbiology, Schools of Dentistry, Medicine and Public Health, University of Alabama at Birmingham 35294 4400, USA
    Hum Immunol 60:984-9. 1999
    ..These results support an hypothesis of an association between host HLA class II and TNFa genetic profile and colonization of S. mutans, L. casei, and L. acidophilus thought to be pathogens involved in the etiology of dental caries...
  97. ncbi A newly characterized HLA DQ beta allele associated with pemphigus vulgaris
    A A Sinha
    Department of Medical Microbiology, Stanford University, CA 94305
    Science 239:1026-9. 1988
    ..In addition to clinical implications, the disease-restricted distribution of this variant should provide insight into the molecular mechanisms underlying associations between diseases and HLA-class II genes...
  98. ncbi HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection
    Beatriz Sierra
    Institute of Tropical Medicine Pedro Kouri, WHO Collaborator Centre for Viral Diseases, Havana, Cuba
    Hum Immunol 68:531-40. 2007
    ....
  99. ncbi Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status
    So Young Bang
    Hospital for Rheumatic Diseases, Hanyang University, Seoul, South Korea
    Arthritis Rheum 62:369-77. 2010
    ....
  100. ncbi Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    Sally C Kent
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 435:224-8. 2005
    ..These results identify insulin-reactive, clonally expanded T cells from the site of autoinflammatory drainage in long-term type 1 diabetics, indicating that insulin may indeed be the target antigen causing autoimmune diabetes...
  101. ncbi Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock
    Thierry Fumeaux
    Department of Internal Medicine, Division of Medical Intensive Care, and Faculty of Medicine, University Hospital of Geneva, Switzerland
    Am J Respir Crit Care Med 166:1475-82. 2002
    ..IL-10 may represent a future target for immunomodulating patients with the sepsis syndrome or critically ill patients at risk of developing infections...

Research Grants65

  1. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..3+ lymphocytes pre and post treatment in the transplanted skin. The overall goal of this proposal is to determine whether Kv1.3 blockade constitutes a potential new therapeutic approach to the treatment of psoriasis. ..
  2. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..These studies will identify if certain genes make individuals more susceptible to the effects of smoking so that an earlier intervention can be done to avoid joint deformities. ..
  3. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ....
  4. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..The new knowledge obtained from the proposed experiments challenges the current dogma and will have an impact on our ability to treat patients with active disease and to maintain the patients'quality of life. ..
  5. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013
    ..2) To study the relevance of cryopyrin and a cryopyrin-adaptor (ASC) in asthma. (3) To study and identify factors which modulate the nucleotide-binding properties and ATPase function of Monarch-1 and cryopyrin. ..
  6. HLA class II transgenic mouse models for S. aureus infections and superantigens
    Govindarajan Rajagopalan; Fiscal Year: 2013
    ..This will be investigated by a series of in vivo studies using transgenic mice expressing HLA-DR2, HLA-DR3, HLA-DR4, HLA-DQ2, HLA-DQ6 or HLA-DQ8 molecules. ..
  7. Naltrexone and AIDS progression
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..If LDN can reduce the progression of AIDS in the highly translational SIV-infected macaque model, the research could validate a low cost and safe intervention to curtail disease progression with little or no side effects. ..
  8. GM-CSF for Immunomodulation Following Trauma (GIFT) Trial
    Mark W Hall; Fiscal Year: 2013
    ..abstract_text> ..
  9. MHC class II-Associated Endothelial Dysfunction
    Joseph Holoshitz; Fiscal Year: 2010
    ..The results of this study could shed much needed light on a disease that shortens life expectancy of rheumatoid arthritis patients and could identify novel targets for future therapy. ..
  10. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ....
  11. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    TERRY FRANCIS DAVIES; Fiscal Year: 2013
    ..The benefit to the individual and society is potentially great in alleviating suffering due to the more severe forms of this thyroid disorder, especially Graves'ophthalmopathy. ..
  12. Rapid, Point-of-Care Diagnosis of Neonatal Sepsis
    GREGORY SOMMER; Fiscal Year: 2013
    ..The company anticipates penetration into the estimated $1.5 billion global clinical neonatal and pediatric monitoring market within 4 years. ..
  13. Role of HLA class II genes in demyelination
    Chella S David; Fiscal Year: 2013
    ..These humanized class II model of EAE can be used to evaluate potential therapeutic protocols and peptide vaccines applicable in the future to MS patients. ..
  14. Role of HCV in aberrant APC activation/function
    Young S Hahn; Fiscal Year: 2013
    ..We believe that results of these studies will provide a basis fr the rational design of vaccines and novel therapeutics against HCV infection in humans by bypassing the immunosuppressive effect of HCV. ..
  15. Analyzing The Joint Susceptibility Genes for Autoimmune Thyroiditis and Diabetes
    Yaron Tomer; Fiscal Year: 2012
    ..the mechanisms causing the strong association between thyroid autoimmunity and type1 diabetes will allow us not only disease predictions within families, but also to develop rational, mechanism-based, treatment and prevention strategies ..
  16. Natural History of Pre-diabetic Autoimmunity (DAISY)
    Marian J Rewers; Fiscal Year: 2013
    ..We will continue to make every effort to share DAISY resources with multiple investigators studying T1D and other autoimmune diseases, striving for an open-source database and repository. ..
  17. Natural History of Pre-diabetic Autoimmunity (DAISY)
    Marian J Rewers; Fiscal Year: 2010
    ..abstract_text> ..
  18. Immune Activation and Isoniazid Metabolism in HIV/TB
    Gregory P Bisson; Fiscal Year: 2013
    ....
  19. A Humanized mouse model of B-islet cell autoimmunity
    Grete Sonderstrup; Fiscal Year: 2010
    ....
  20. BIOMEDICAL (BASIC)
    Larry Moreland; Fiscal Year: 2009
    ..abstract_text> ..
  21. Structure-function of HLA-DR, peptides, and T cells in autoimmune arthritis
    Edward F Rosloniec; Fiscal Year: 2013
    ..VA Public ..
  22. Thyroid Derived Peptide Presentation by HLA-DR in Thyroiditis
    Yaron Tomer; Fiscal Year: 2013
    ..Our translational studies will hopefully lead to novel therapies for AITD. ..
  23. Transfusion Infection Pediatric Prospective Study (TRIPPS)
    NAOMI L LUBAN; Fiscal Year: 2011
    ..This application focuses on infants and children, a vulnerable and heretofore poorly studied recipient group. ..
  24. The genetic basis of type 1 diabetes autoimmunity in African Americans
    Janelle A Noble; Fiscal Year: 2013
    ....
  25. T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Shu Man Fu; Fiscal Year: 2013
    ..This will provide a theoretical framework from which rational therapeutic approach can be devised. ..
  26. The effect of peptide therapy and allergen provocation on Fel d1-specific T Cells
    Mark Larché; Fiscal Year: 2013
    ..Additionally this Aim will assess the effects of peptide immunotherapy in the murine allergen challenge model ..
  27. Role of HLA-DR3 in Pathogenesis of Systemic Lupus Erythematosus (SLE)
    VAIDEHI RADHAKRISHNA CHOWDHARY; Fiscal Year: 2013
    ..This will provide a theoretical framework from which rational therapeutic approach can be devised for treatment and prevention of SLE. ..
  28. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptide
    Lbachir BenMohamed; Fiscal Year: 2013
    ....
  29. The Environmental Triggers of Diabetes (TEDDY) in Sweden
    Ake Lernmark; Fiscal Year: 2012
    ..Participants will be followed to age 15 years. Identification of environmental factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1 D. ..
  30. The TEDDY study: Georgia/Florida clinical center
    Jin Xiong She; Fiscal Year: 2012
    ..The prospectively collected specimens on TEDDY subjects provide a unique opportunity for scientists within and outside the TEDDY consortium to test novel hypotheses by performing otherwise impossible critical studies. ..
  31. The cervical microbiome mediates hormonal increases in HIV1 susceptibility
    Daniel Frank; Fiscal Year: 2012
    ....
  32. HLA/KIR Region Genetics in Pediatric Arthritis
    David N Glass; Fiscal Year: 2010
    ..Some of the patients will also have extensive gene expression studies allowing a comprehensive approach to the MHC and KIR genes in JRA and its subtypes. ..
  33. Characterization of Human Regulatory T cell-induced Dendritic Cells
    MICHAEL ALONSO; Fiscal Year: 2010
    ..The proposed studies will provide mechanistic insights into this previously unknown pathway of immune regulation and will reveal novel therapeutic targets that may interrupt this pathway and amplify anti-tumor responses. ..
  34. Multi-peptide Vaccine Administered with Cyclophosphamide for High-risk Melanoma
    CRAIG LEE SLINGLUFF; Fiscal Year: 2010
    ....
  35. Genomics of Lupus
    JOHN BARKER HARLEY; Fiscal Year: 2013
    ..The resulting level of understanding promises to establish the genetic etiology of lupus, spawn new diagnostics, prognostics, and therapeutics which provide therapeutic benefit to this and many related illnesses. ..
  36. THE TEDDY STUDY - COLORADO CLINICAL CENTER
    Marian J Rewers; Fiscal Year: 2012
    ..A successful study outcome should allow better understanding of the etiology and pathogenesis of T1D and the development of new strategies to prevent, delay, or reverse the disease. ..
  37. A new small molecule targeting agent and therapeutic for non-Hodgkin's lymphoma
    Rodney Balhorn; Fiscal Year: 2011
    ....
  38. Permissive Specificity in Peptide Binding to HLA-DR
    JACK A GORSKI; Fiscal Year: 2012
    ..abstract_text> ..
  39. Cell Free System for Identification of MHC Class II Immunodominant Epitopes
    Scheherazade Sadegh-Nasseri; Fiscal Year: 2011
    ..Thus, the new technology proposed in this project takes a major leap forward in predicting accurately immunodominant peptides. Project ..
  40. Application of Novel Antigens and Integrated Microfluidics for Leprosy Diagnosis
    Robert L Modlin; Fiscal Year: 2013
    ....
  41. UROTHELIAL CELL ACTIVATION IN INTERSTITIAL CYSTITIS
    Monica Liebert; Fiscal Year: 1993
    ....
  42. The Dry Eye Evaluation And Management (DREAM) Study: Coordinating Center
    Maureen G Maguire; Fiscal Year: 2013
    ..abstract_text> ..
  43. The TEDDY study: Georgia/Florida clinical center
    Jin Xiong She; Fiscal Year: 2013
    ..A successful study outcome should allow better understanding of the etiology and pathogenesis of islet autoimmunity and T1D and the development of new strategies to prevent, delay, or reverse the disease. ..
  44. Dendritic cells in psoriasis and effects of efalizumab
    Michelle A Lowes; Fiscal Year: 2010
    ..Furthermore, I will determine the extent to which efalizumab has direct effects on growth, differentiation and activation of DCs versus indirect effects through T cell modulation. ..
  45. Innate Immune Response Genetics and T cell Activation in Treated HIV Infection
    Peter W Hunt; Fiscal Year: 2010
    ..This research project will help identify inflammatory pathways that prevent immune system recovery in these patients, eventually leading to targeted interventions to improve immune system recovery. ..
  46. Targeted Therapy of B-cell Malignancies
    David Goldenberg; Fiscal Year: 2009
    ..Collectively, the integration of all of these different, but related endeavors promises to provide new knowledge and strategies for the improved management of B-cell malignancies. ..
  47. The Environmental Determinants of Diabetes in the Young (TEDDY) Colorado Clinical
    Marian J Rewers; Fiscal Year: 2013
    ..A successful study outcome should allow better understanding of the etiology and pathogenesis of islet autoimmunity and T1D and the development of new strategies to prevent, delay, or reverse the disease. ..
  48. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  49. The Environmental Determinants of Diabetes in Youth: Washington Clinical Center
    William A Hagopian; Fiscal Year: 2013
    ..A successful study outcome should allow better understanding of the etiology and pathogenesis of islet autoimmunity and T1D and the development of new strategies to prevent, delay, or reverse the disease. ..
  50. GENETIC ANALYSIS OF ALTERED IMMUNITY IN CELIAC DISEASE
    JOSEPH MICHALSKI; Fiscal Year: 1990
    ..The results of these studies may help elucidate the genetic basis of celiac disease, and will clarify the clinical significance of immune abnormalities attributed to genes in the HLA region...
  51. Functional impact of CD8+ T cell subsets in NeuroHIV
    Maureen H Richards; Fiscal Year: 2013
    ..Findings from these studies will be informative regarding basic biology of these cells as well as guide novel therapeutic strategies exploiting their role in CNS. ..
  52. The Environmental Determinants of Diabetes in Youth: Washington Clinical Center
    William A Hagopian; Fiscal Year: 2012
    ..6. Guide the ongoing TEDDY project by participation of the Clinical Center investigators and staff in work of the study Steering Committee and sub-committees. ..
  53. Limited Competition for the Continuation of Clinical Centers for the Environment
    ANETTE ZIEGLER; Fiscal Year: 2013
    ..A successful study outcome should allow better understanding of the etiology and pathogenesis of islet autoimmunity and T1D and the development of new strategies to prevent, delay, or reverse the disease. ..
  54. DECREASING SEVERITY OF RECURRENT HEPATITIS C IN LIVER
    Lakshmi Gaur; Fiscal Year: 1999
    ....
  55. Mechanisms for HLA-DQ mediated disease protection and susceptibility
    William W Kwok; Fiscal Year: 2012
    ..These observations will illuminate important early events in disease progression, providing a new biomarker and suggesting important new avenues for therapy. ..
  56. Correlates and Consequences of Increased Immune Activation in HIV + and - IDUs
    MARTIN H MARKOWITZ; Fiscal Year: 2013
    ..By studying the intersection of IDU and infection with HIV-1 and HCV, we aim to improve treatment outcomes in affected populations and individuals. ..
  57. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2007
    ..abstract_text> ..
  58. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..abstract_text> ..
  59. IMMUNE MEDIATED BLADDER INFLAMMATION
    Timothy Ratliff; Fiscal Year: 2002
    ..10 T cell receptor transgenic model, and (3) determine the effects of CD4+ T cell-directed chronic bladder inflammation on bladder function and evaluate strategies for modifying the response. ..
  60. MULTI-EPITOPE MELANOMA VACCINES FOR CD4 AND CD8 T-CELLS
    Craig Slingluff; Fiscal Year: 2009
    ....
  61. MOLECULAR MECHANISM OF IMMUNOTOXIC ACTION OF TCDD & DDT
    Fusao Hirata; Fiscal Year: 1993
    ....
  62. GENETIC ANALYSIS OF PSORIASIS
    Anne Bowcock; Fiscal Year: 2001
    ..When alterations are found, they will be screened for in 100 unrelated controls to determine the possibility of their contributing to the development of psoriasis. ..
  63. MICROBIAL TRANSLOCATION &ALTERATIONS IN GUT MICROBIOMES IN HIV INFECTED CHILDREN
    CHARLES DEBEAUX MITCHELL; Fiscal Year: 2013
    ....
  64. NK AND T-CELL DEVELOPMENT FROM HEMATOPOIETIC STEM CELLS
    Jeffrey Miller; Fiscal Year: 1999
    ..Single cell analysis and retroviral marking studies will be employed to document the common origin of myeloid and NK/T progenitors in sequential microenvironment specific switch cultures. ..
  65. Genetic Polymorphisms in Rheumatoid Arthritis
    Eric Matteson; Fiscal Year: 2004
    ..The mentorship program proposed in this grant is critical to this long-term goal. ..