hla d antigens

Summary

Summary: Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.

Top Publications

  1. ncbi Altered antigen presentation in mice lacking H2-O
    M Liljedahl
    The R W Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA
    Immunity 8:233-43. 1998
  2. ncbi The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
    P Ghosh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 378:457-62. 1995
  3. ncbi HLA-DO is an intracellular class II molecule with distinctive thymic expression
    D C Douek
    Transplantation Biology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Int Immunol 9:355-64. 1997
  4. ncbi Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM
    P E Jensen
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Biol 8:R128-31. 1998
  5. pmc HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport
    M Liljedahl
    The R W Johnson Pharmaceutical Research Institute at The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 15:4817-24. 1996
  6. pmc Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
    M van Ham
    Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Exp Med 191:1127-36. 2000
  7. ncbi Determination of the HLA-DM interaction site on HLA-DR molecules
    R C Doebele
    School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Immunity 13:517-27. 2000
  8. ncbi Negative regulation by HLA-DO of MHC class II-restricted antigen processing
    L K Denzin
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA
    Science 278:106-9. 1997
  9. ncbi Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes
    T A Gondré-Lewis
    Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983
    J Immunol 166:6657-64. 2001
  10. ncbi Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
    D A Weber
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 274:618-20. 1996

Research Grants

Detail Information

Publications187 found, 100 shown here

  1. ncbi Altered antigen presentation in mice lacking H2-O
    M Liljedahl
    The R W Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA
    Immunity 8:233-43. 1998
    ..This effect may serve to decrease the presentation of antigens internalized by fluid-phase endocytosis, thus concentrating the B cell-mediated antigen presentation to antigens internalized by membrane immunoglobulin...
  2. ncbi The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
    P Ghosh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 378:457-62. 1995
    ..The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM...
  3. ncbi HLA-DO is an intracellular class II molecule with distinctive thymic expression
    D C Douek
    Transplantation Biology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Int Immunol 9:355-64. 1997
    ..Hassall's corpuscles, a medullary site of thymocyte death, are ringed by HLA-DO+ epithelium. This unusual pattern of expression may suggest a specialized role for HLA-DO in the thymus...
  4. ncbi Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM
    P E Jensen
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Biol 8:R128-31. 1998
    ..HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules...
  5. pmc HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport
    M Liljedahl
    The R W Johnson Pharmaceutical Research Institute at The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 15:4817-24. 1996
    ..The DO-DM complexes survive in the lysosomal system suggesting that DO and DM functions may be intertwined...
  6. pmc Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
    M van Ham
    Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Exp Med 191:1127-36. 2000
    ..DO may serve to increase the threshold for nonspecific B cell activation, restricting class II-peptide binding to late endosomal compartments, thereby affecting the peptide repertoire...
  7. ncbi Determination of the HLA-DM interaction site on HLA-DR molecules
    R C Doebele
    School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Immunity 13:517-27. 2000
    ..In vitro, these mutant DR3 molecules were resistant to DM-catalyzed CLIP release and showed reduced binding to DM. All mutations localize to a single lateral face of HLA-DR, which we propose interacts with DM during peptide exchange...
  8. ncbi Negative regulation by HLA-DO of MHC class II-restricted antigen processing
    L K Denzin
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA
    Science 278:106-9. 1997
    ....
  9. ncbi Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes
    T A Gondré-Lewis
    Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983
    J Immunol 166:6657-64. 2001
    ..of Ag-BCR complexes within nonterminal late endosomes and suggest that this intracellular Ag persistence allows for the prolonged cell surface expression of peptide-class II complexes derived from the processing of specific AG:..
  10. ncbi Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
    D A Weber
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 274:618-20. 1996
    ..In antigen presentation, DM has the potential to markedly enhance the rate of peptide exchange, favoring the presentation of peptides with slower intrinsic rates of dissociation...
  11. ncbi Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides
    Achal Pashine
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    Immunity 19:183-92. 2003
    ..Peptide release from the complexes was fast and only weakly sequence dependent, arguing that DM diminishes the selectivity of the MHCII groove. Analysis of soluble DM action on soluble DR/peptide complexes corroborates this conclusion...
  12. pmc HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes
    Kedar Narayan
    Graduate Program in Immunology, Johns Hopkins University Baltimore, Maryland 21205, USA
    Nat Immunol 8:92-100. 2007
    ..We suggest that DM may mediate peptide dissociation by a 'hit-and-run' mechanism that results in conformational changes in MHC class II molecules and disruption of hydrogen bonds between betaHis81 and bound peptide...
  13. pmc The kinetic basis of peptide exchange catalysis by HLA-DM
    J A Zarutskie
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 98:12450-5. 2001
    ..Thus, HLA-DM serves essentially as a protein-folding or conformational catalyst...
  14. pmc Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs
    S M van Ham
    Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Holborn, London, United Kingdom
    J Exp Med 184:2019-24. 1996
    ..Thus, HLA-DM acts as a peptide editor, facilitating selection of peptides that stably bind to class II molecules for eventual presentation to the immune system from the pool of available peptides...
  15. pmc Small molecules that enhance the catalytic efficiency of HLA-DM
    Melissa J Nicholson
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 176:4208-20. 2006
    ..A hydrophobic ridge in the DMbeta1 domain was implicated in the catalysis of peptide exchange because the activity of three of these enhancers was substantially reduced by point mutations in this area...
  16. ncbi Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain
    Efstratios Stratikos
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 172:1109-17. 2004
    ..These results suggest that peptides or compounds that bind MHC but cannot form these interactions would be preferentially edited out by HLA-DM...
  17. ncbi Crystal structure of mouse H2-M
    D H Fremont
    Center for Immunology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 9:385-93. 1998
    ..The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor...
  18. pmc Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis
    Efstratios Stratikos
    Department of Cellular and Molecular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 196:173-83. 2002
    ....
  19. ncbi Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM
    Michael P Belmares
    Departments of Chemistry and Pediatrics, Stanford University, Stanford, California 94305, USA
    Biochemistry 42:838-47. 2003
    ..Intramolecular isomer interconversion does not appear to be involved. The behavior of these complexes may provide a model for peptide editing by DM in endosomes...
  20. ncbi The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif
    R Lindstedt
    R W Johnson Pharmaceutical Research Institute, Scripps Research Institute, La Jolla, California 92037, USA
    Immunity 3:561-72. 1995
    ..Thus, the targeting motif of H2-M appears to be supplementary, rather than essential for class II-peptide association...
  21. ncbi A new human HLA class II-related locus, DM
    A P Kelly
    Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Holborn, London, UK
    Nature 353:571-3. 1991
    ..The RING6 and RING7 genes seem to encode alpha- and beta-chains of a previously undiscovered class II-related protein...
  22. ncbi HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
    S M van Ham
    Department of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX Amsterdam, The Netherlands
    Curr Biol 7:950-7. 1997
    ..Recently, HLA-DO, an unconventional class II molecule, has been found associated with HLA-DM in B cells, yet its function has remained elusive...
  23. ncbi HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells
    S P Fling
    Department of Pediatrics, University of Washington, Seattle 98195
    Nature 368:554-8. 1994
    ..They suggest that HLA-DMA and -DMB encode subunits of a functional heterodimer which is critical in the pathway of class II antigen presentation...
  24. ncbi DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
    M A Sherman
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Immunity 3:197-205. 1995
    ..We conclude that DM is a cofactor that enhances peptide binding to DR molecules through a mechanism involving peptide exchange...
  25. ncbi The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation
    L Mosyak
    Department of Cellular and Molecular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Immunity 9:377-83. 1998
    ....
  26. pmc A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes
    Heather J Cordell
    Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 70:124-41. 2002
    ..The methods are illustrated using nuclear-family data to evaluate the contribution of loci in the HLA region to the development of type 1 diabetes...
  27. pmc Editing of the HLA-DR-peptide repertoire by HLA-DM
    H Kropshofer
    German Cancer Research Center, Department of Molecular Immunology, Heidelberg, Germany
    EMBO J 15:6144-54. 1996
    ....
  28. ncbi A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study
    Minna Kiviniemi
    Immunogenetics Laboratory and MediCity Research Laboratory, University of Turku, Finland
    Diabetes Technol Ther 9:460-72. 2007
    ..Also, a simple, low-cost, and fast screening system was essential for the primary step of the risk assessment including thousands of samples...
  29. ncbi Transmembrane domain-mediated colocalization of HLA-DM and HLA-DR is required for optimal HLA-DM catalytic activity
    D A Weber
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 167:5167-74. 2001
    ..Our findings demonstrate the importance of membrane anchoring in DM activity and underscore the potential importance of membrane localization in regulating peptide exchange by class II molecules...
  30. ncbi Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients
    W Thomson
    Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 41:1183-9. 2002
    ..To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria...
  31. ncbi MHC class II proteins and disease: a structural perspective
    E Yvonne Jones
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Rev Immunol 6:271-82. 2006
    ..Here, we discuss the insights that the crystal structures of MHC class II molecules provide into the molecular mechanisms by which sequence polymorphisms might contribute to disease susceptibility...
  32. ncbi Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body
    M van Lith
    Division of Tumor Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Immunol 167:884-92. 2001
    ..Sorting of DM/DO and class II molecules to specific localizations within the MIIC represents a novel way of regulating MHC class II Ag presentation...
  33. ncbi Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes
    H Kropshofer
    Basel Institute for Immunology, 4005 Basel, Switzerland
    Nat Immunol 3:61-8. 2002
    ....
  34. ncbi How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?
    H Kropshofer
    Dept of Molecular Immunology, German Cancer Research Center, Heidelberg
    Immunol Today 18:77-82. 1997
    ....
  35. ncbi Peptide exchange in MHC molecules
    P E Jensen
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Immunol Rev 172:229-38. 1999
    ..However, exchange reactions may play an important role in editing the repertoire of peptides presented by both class II and class I molecules, thus influencing the specificity of immunity and tolerance...
  36. ncbi The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed
    P R Wolf
    Department of Pathology, Harvard Medical School, Boston 02115, USA
    Eur J Immunol 28:2605-18. 1998
    ..Some of these findings in vivo contrast significantly with findings from in vitro studies on murine MHC class II molecules in human DM-deficient cell lines...
  37. ncbi Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM
    R Busch
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Biol Chem 273:27557-64. 1998
    ..The change seems to involve both hydrogen bonding patterns and the hydrophobic core of sDM and may contribute to the pH dependence of DM activity...
  38. ncbi Cutting edge: TCR contacts as anchors: effects on affinity and HLA-DM stability
    Matthew W Anderson
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201, USA
    J Immunol 171:5683-7. 2003
    ..We propose that these effects may be mediated through the H-bond network. These results demonstrate the importance of solvent-exposed residues in epitope selection and blur the distinctions between anchor and TCR contact residues...
  39. pmc Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis
    Justin P Rubio
    Walter and Eliza Hall Institute of Medical Research, and Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Victoria, Australia
    Am J Hum Genet 70:1125-37. 2002
    ..We propose that the analysis of haplotypes, by use of the types of approaches outlined in the present article, should make it possible to more accurately define the contribution of the HLA to MS...
  40. ncbi The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript
    J A Young
    Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Immunogenetics 31:386-8. 1990
  41. pmc The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
    L Karlsson
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    J Exp Med 176:477-83. 1992
    ..These results indicate that the human HLA-DNA gene, the existence of which has long been known, is indeed coding for DO alpha, the alpha chain pairing with DO beta...
  42. ncbi Human leukocyte antigen class II control of the immune response to p126-derived amino terminal peptide from Plasmodium falciparum
    Dalma M Banic
    Laboratório de Pesquisas em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    Am J Trop Med Hyg 66:509-15. 2002
    ..Thus, naturally exposed people with different HLA class II antigens seem to respond differently to Nt47, indicating that the choice of relevant peptide sequences may have important consequences for subunit vaccine development...
  43. ncbi Structural factors contributing to DM susceptibility of MHC class II/peptide complexes
    Michael P Belmares
    Department of Chemistry, Stanford University, CA 94305, USA
    J Immunol 169:5109-17. 2002
    ..Thus, the peptide repertoire displayed to CD4(+) T cells is the result of a mechanistically complicated editing process and cannot be simply predicted from the intrinsic stability of the complexes in the absence of DM...
  44. ncbi Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium
    K A Muczynski
    Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 59:488-97. 2001
    ....
  45. ncbi Differential up-regulation of HLA-DM, invariant chain, and CD83 on myeloid and plasmacytoid dendritic cells from peripheral blood
    J Gomez
    Histocompatibility and Immunogenetics Research Group, National Blood Service, Colindale Avenue, London, UK
    Tissue Antigens 63:149-57. 2004
    ..The expression pattern of these antigen-processing molecules could be related to the immaturity and function attributed to these DC subsets...
  46. ncbi HLA-DR4 molecules in neuroendocrine epithelial cells associate to a heterogeneous repertoire of cytoplasmic and surface self peptides
    Aura Muntasell
    Immunology Unit and Institute of Biotechnology and Biomedicine, Universitat Autonoma de Barcelona, Spain
    J Immunol 169:5052-60. 2002
    ..This is specially relevant to processes involving epithelial T cell interactions such as organ-specific autoimmunity and transplant rejection...
  47. ncbi Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non-Ashkenazi Jewish, and in Israeli Arab IDDM patients
    O J Kwon
    The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Hum Immunol 62:85-91. 2001
    ..These findings support the results obtained in other studies, which point to a genetic relationship between the Israeli and Mediterranean populations...
  48. pmc Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation
    Mathieu S Chevalier
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201, USA
    J Virol 76:8265-75. 2002
    ..Our results are consistent with the hypothesis that US2 couples MHC proteins to components of the ER degradation pathway, enormously increasing the rate of degradation of MHC proteins...
  49. pmc Functional HLA-DM on the surface of B cells and immature dendritic cells
    S O Arndt
    Department of Molecular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    EMBO J 19:1241-51. 2000
    ..Thus, this novel concept of functional DM on the surface may be relevant to both protective immune responses and autoimmunity...
  50. ncbi Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion
    Jürgen Neumann
    Section of Immunobiology, Institute for Molecular Physiology, University of Bonn, Bonn, Germany
    J Immunol 171:3075-83. 2003
    ..Evaluation of DR, DM, and gB subcellular localization revealed abundant changes in intracellular distribution. DR-gB complexes are localized in subcellular vesicles and restrained from cell surface expression...
  51. ncbi Inhibition of the MHC class II antigen presentation pathway by human cytomegalovirus
    D C Johnson
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97201, USA
    Curr Top Microbiol Immunol 269:101-15. 2002
    ..The existence of these proteins indicates the importance of class II-mediated presentation of endogenous antigens in signalling virus infection to CD4+ T cells...
  52. ncbi Indirect allorecognition of mismatched donor HLA class II peptides in lung transplant recipients with bronchiolitis obliterans syndrome
    S I Reznik
    Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Transplant 1:228-35. 2001
    ..These results suggest that indirect alloreactivity to donor HLA class II molecules may play a role in the pathogenesis of BOS after lung transplantation...
  53. ncbi Uncoordinated HLA-D gene expression in a RFXANK-defective patient with MHC class II deficiency
    A M Lennon-Dumenil
    Institut National de la Santé et de la Recherche Médicale Unité 276, Institut Pasteur, Paris, France
    J Immunol 166:5681-7. 2001
    ....
  54. ncbi Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules
    Brendan Byrne
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Hum Immunol 63:977-86. 2002
    ..These results suggest that nondiseased human duodenal EC can process and present antigen by the MHC class II pathway, but that they may induce anergy, rather than activation, of local T cells...
  55. pmc Human cytomegalovirus US2 causes similar effects on both major histocompatibility complex class I and II proteins in epithelial and glial cells
    Nagendra R Hegde
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Virol 77:9287-94. 2003
    ..We concluded that US2 has broad effects in a variety of cells that express both class I and II proteins and is relevant to HCMV infection in vivo...
  56. ncbi HLA-DM, HLA-DO and tapasin: functional similarities and differences
    Pascale Brocke
    DKFZ Deutsches Krebsforschungszentrum, German Cancer Research Center, Molecular Immunology, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Curr Opin Immunol 14:22-9. 2002
    ..The picture emerges that DM and tapasin have analogous functions in shaping the peptide repertoire presented by the respective MHC class II and class I molecules...
  57. ncbi The impact of H2-DM on humoral immune responses
    C Alfonso
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    J Immunol 167:6348-55. 2001
    ..Hence, while substantial Ab responses can be raised in the absence of DM, this molecule is a crucial factor both for Ag processing and for the normal maturation of T-dependent humoral immune responses in vivo...
  58. ncbi Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO
    Cecile Chalouni
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Int Immunol 15:457-66. 2003
    ..Taken together, our results show that human GC B cells differ from naive and memory B cells by their aggregated MIIC that lack HLA-DO...
  59. pmc Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation
    Krzysztof Masternak
    Department of Genetics and Microbiology, University of Geneva Medical School, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    EMBO J 21:1379-88. 2002
    ..Our results support the general notion that the impact of a particular activator on transcription in vivo may vary depending on the promoter and the chromatin context...
  60. ncbi Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor
    Tara M C Hornell
    Department of Pediatrics, School of Medicine, Stanford University, CCSR Room 2120, 269 Campus Drive, Stanford, CA 94305, USA
    J Immunol 171:2374-83. 2003
    ..Thus, our data argue that the proinflammatory role of GM-CSF is mediated in part through increased expression of key molecules involved in the class II MHC pathway via induction of CIITA...
  61. ncbi Is there MHC Class II restriction of the response to MHC Class I in transplant patients?
    Andreas C Papassavas
    Transplantation Immunology, Oxford Transplant Centre, Churchill Hospital, Oxford Radcliffe Hospitals Trust, United Kingdom
    Transplantation 73:642-51. 2002
    ..In this study, we evaluated distinct HLA-DRB1 alleles to determine class II restriction of the production of HLA-A2-specific antibodies in renal transplant patients...
  62. ncbi Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules
    Kirsten Falk
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 277:2709-15. 2002
    ..These molecules may therefore be extremely useful for the loading of antigens onto dendritic cells for therapeutic purposes...
  63. pmc Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes
    Rene J Duquesnoy
    Division of Transplantation Pathology and Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transpl Immunol 18:352-60. 2008
    ..These data demonstrate that HLA class II reactive sera display distinct specificity patterns associated with structurally defined epitopes on different HLA-D alleles...
  64. ncbi Regulation of class II expression in monocytic cells after HIV-1 infection
    S Rakoff-Nahoum
    Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 167:2331-42. 2001
    ..HIV-1 appears to have multiple effects on class II expression in monocytic cells that may contribute to the immune defects seen in HIV-1-infected patients...
  65. pmc A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules
    Olaf Rotzschke
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:16946-50. 2002
    ..0 but opens below pH 6.0 to allow conformational transitions necessary for ligand exchange...
  66. ncbi Confirmation of graft-versus-host disease by HLA typing after liver transplantation
    A Arrieta
    Section of Immunology, Hospital de Cruces, Baracaldo, Vizcaya, Spain
    Transplant Proc 34:278-9. 2002
  67. ncbi HLA class I and class II are both associated with the genetic predisposition to primary Sjögren syndrome
    P Loiseau
    Laboratoire d Immunologie et d Histocompatibilité, Hôpital Saint Louis AP HP, Paris, France
    Hum Immunol 62:725-31. 2001
    ..The novel association of HLA class I alleles with susceptibility to pSS provides new insights to the genetic predisposition to this disease and subsequently to its physiopathology...
  68. ncbi Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033
    R de Pablo
    Servicio de Inmunologia, Clinica Puerta de Hierro, Madrid, Spain
    Tissue Antigens 59:44-6. 2002
    ..The phenotype of G081 (A*01; B*0702, *1302/1303; Cw*0602, *07; DRB1*0403, *0701; DRB4*0103101, *01033; DQB1*0202, *0302; DQA1*0201, *0301) is consistent with a proposed association of DRB4*01033 with DRB1*0403 and DQB1*0302...
  69. ncbi Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience
    E W Petersdorf
    Fred Hutchinson Cancer Research Center, the U.S. National Marrow Donor Program, Georgetown University, Memorial Sloan Kettering Cancer Center, USA
    Blood 98:2922-9. 2001
    ..Furthermore, a good-risk population of patients whose transplantations were performed in the first CP of disease from HLA-A, B, DRB1 matched unrelated donors can be shown to have superior survival...
  70. ncbi Kidney graft failure and presensitization against HLA class I and class II antigens
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Transplantation 73:1269-73. 2002
    ..We investigated the clinical relevance of preformed anti-HLA class I and class II antibodies on graft outcome in more than 4000 kidney recipients...
  71. ncbi HLA class II alleles and salivary numbers of mutans streptococci and lactobacilli among young adults in Japan
    Y Ozawa
    Department of Preventive Dentistry, Tohoku University School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
    Oral Microbiol Immunol 16:353-7. 2001
    ..05). These observations suggest that HLA class II alleles may be related to the salivary populations of oral microorganisms, such as mutans streptococci and lactobacilli...
  72. ncbi Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes
    Sarah F Field
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1753-6. 2008
    ....
  73. ncbi Associations between HLA class II alleles and type 1 diabetes mellitus in the Slovak population
    M Buc
    Department of Immunology, Comenius University School of Medicine, Czech Republic
    Endocr Regul 40:1-6. 2006
    ..This study was therefore prompted to be conducted in Slovak population, since any such has not yet been performed in Slovak population...
  74. ncbi Characterization of two distinct DR beta chain alleles at the beta III locus of the DR5 haplotype: beta III alleles are highly conserved
    D K Didier
    J Immunol 137:2627-31. 1986
    ....
  75. ncbi A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs
    Carolyn Katovich Hurley
    Department of Oncology, Georgetown University, Washington, DC, USA
    Hum Immunol 68:30-40. 2007
    ....
  76. ncbi Structural and functional variability among DQ beta alleles of DR2 subtypes
    B S Lee
    Immunogenetics 26:85-91. 1987
    ..Thus, the polymorphism among DQ beta alleles within DR2 results in subtype-specific restriction...
  77. ncbi Human leukocyte antigen class II alleles and risk of cervical cancer in China
    Yuping Wu
    State Key Laboratory of Biocontrol, Department of Biochemistry, School of Life Sciences, Sun Yat Sen Zhongshan University, Guangzhou, P R China
    Hum Immunol 68:192-200. 2007
    ....
  78. ncbi All peptide-MHC complexes are not created equal
    Peter E Jensen
    Nat Immunol 3:14-5. 2002
  79. ncbi Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics
    Pedro Cano
    University of Texas M D Anderson Cancer Center, HLA Typing Laboratory, Houston, Texas 77054, USA
    Hum Immunol 68:392-417. 2007
    ..The criteria were established for proficiency testing, which could be a valuable tool when making clinical histocompatibility decisions...
  80. ncbi Haplotype-specific pattern of association of human major histocompatibility complex with non-Hodgkin's lymphoma outcome
    J Nowak
    Laboratory of Immunogenetics, Institute of Haematology and Transfusion Medicine, Warsaw, Poland
    Tissue Antigens 71:16-26. 2008
    ..Further study will be required in NHL patients by fine mapping with dense microsatellite or SNP tags to define susceptibility genes in associating regions...
  81. ncbi The presence of donor-specific human leukocyte antigen antibodies does not preclude successful withdrawal of tacrolimus in stable renal transplant recipients
    Ellen Kreijveld
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands
    Transplantation 84:1092-6. 2007
    ..The presence of human leukocyte antigen (HLA) antibodies has been negatively associated with transplant outcome. Therefore, we evaluated the impact of HLA antibodies on the occurrence of acute rejection after immunosuppression reduction...
  82. ncbi HLA Class II-specific antibodies can react with T cells in flow cytometry crossmatch: a case report
    W B Heo
    Department of Clinical Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Transplant Proc 39:3485-7. 2007
    ..This case suggested donor-specific HLA Class II-specific antibodies can bind to some T cells as well as to whole B cells...
  83. ncbi Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation
    C Lefaucheur
    Department of Nephrology, Saint Louis Hospital, Paris, France
    Am J Transplant 8:324-31. 2008
    ..Our findings demonstrate the importance of detection and characterization of DSA before transplantation. Stratification of this risk could be used to determine kidney allocation and to devise specific strategies for these patients...
  84. ncbi Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes
    C P Liu
    Department of Laboratory Medicine Pathology, University of Minnesota, Minneapolis 55455
    J Immunol 140:3631-9. 1988
    ....
  85. ncbi Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis
    D P Singal
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Rheumatol 12:29-33. 1994
    ..It is likely that the genetic variability in the putative peptide transporter could also be implicated in immunological disorders associated with MHC...
  86. ncbi "Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules
    Viviana Marin-Esteban
    Max Delbruck Center for Molecular Medicine, Robert Rösslestrasse 10, 13125 Berlin, Germany
    J Biol Chem 279:50684-90. 2004
    ..These "chemical analogues" of HLA-DM can therefore modulate the response of CD4+ T cells by editing the antigen composition of surface-bound class II major histocompatibility complex on living antigen-presenting cells...
  87. ncbi Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment
    A Zung
    Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel
    Hum Immunol 65:1463-8. 2004
    ..621, p = 0.04). We concluded that ongoing exposure of genetically predisposed immigrants from Ethiopia to diabetogenic environmental factors eventually leads to a high incidence of overt diabetes in this ethnic group...
  88. ncbi The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
    H Kropshofer
    Department of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany
    Immunol Rev 172:267-78. 1999
    ..Together, HLA-DM and HLA-DO are critical factors in shaping the MHC class II-associated self or foreign peptide repertoire of antigen presenting cells and, hence, govern initiation or prevention of an immune response...
  89. ncbi HLA class II haplotypes in Mexican systemic lupus erythematosus patients
    Lizette M Cortes
    Division of Immunology, HCMNO Instituto Mexicano del Seguro Social, Guadalajara, Mexico
    Hum Immunol 65:1469-76. 2004
    ..As expected, patients with SLE have a reduced haplotype genetic diversity. The associations found in this study are related to an ancestral haplotype that has been observed in SLE populations of different origins...
  90. ncbi Allelic diversity at the primate MHC-DMB locus: presence of a conserved tyrosine inhibitory motif in the cytoplasmic tail
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 51:174-82. 1998
    ..Finally, a clade grouping human and gorilla DMB cDNA sequences is obtained using a dendrogram (as for C4d trees); this is in contrast to others' results that obtain a human/chimpanzee clade using different DNA sequences...
  91. ncbi Immunoselection of functional CMRF-56+ blood dendritic cells from multiple myeloma patients for immunotherapy
    Kristen J Radford
    Mater Medical Research Institute, South Brisbane 4101, Australia
    J Immunother 28:322-31. 2005
    ..These data suggest that BDCs with in vitro functional integrity can be isolated from MM patients in sufficient numbers to justify a clinical trial...
  92. ncbi Discordant expression of HLA class II-associated co-chaperones and HLA-DRB alleles in cultured fibroblast-like synoviocytes
    David R Spurrell
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Hum Immunol 65:1516-29. 2004
    ..Altered expression of specific peptide-dependent epitopes on RA-associated HLA-DR molecules suggests differences in antigen presentation by cFLS, which may have implications for the immunopathogenesis of RA...
  93. ncbi Genetic influences on sarcoidosis
    M Ishihara
    Department of Ophthalmology, Yokohama City University, School of Medicine, Kanagawa, Japan
    Eye (Lond) 11:155-61. 1997
    ..None of these genes suggested a susceptibility to sarcoidosis. These studies support the thesis that one of the major genetic factors controlling the development of sarcoidosis is located within the DRB1 locus in the HLA class II region...
  94. ncbi HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom
    K Suzuki
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Tissue Antigens 65:459-66. 2005
    ....
  95. ncbi Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis
    U A Badrising
    Department of Neurology, K5Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 63:2396-8. 2004
    ..Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM...
  96. ncbi HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing
    Angelique Bellemare-Pelletier
    Laboratoire d Immunologie Moléculaire, Departement de Microbiologie et Immunologie, Universite de Montreal, CP 6128, Quebec, Canada
    J Leukoc Biol 78:95-105. 2005
    ..These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy...
  97. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
    ..In addition, our findings provide insights into the origin of the anti-dsDNA Abs often detected in patients with systemic lupus erythematosus...
  98. ncbi Inverse correlation between HLA-DR antigen expression and CD4 positive lymphocytic populations in normal mucosa, tubulovillous adenoma, and invasive carcinoma of the colon
    D Tamiolakis
    Department of Cytology, General Hospital of Alexandroupolis, Greece
    Cesk Patol 42:52-8. 2006
    ..HLA-DR expression was correlated to histological grade and Dukes stage in the cases of invasive cancer. Yet, we investigated the association of HLA-DR plus DQ genes and adenoma or carcinoma by PCR...
  99. pmc HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection
    C G Meyer
    Department of Molecular Biology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Proc Natl Acad Sci U S A 91:7515-9. 1994
    ..The findings indicate that HLA-D variants influence the course of O. volvulus infection and help to define a state that may reflect protective immunity...
  100. ncbi Two divergent routes of evolution gave rise to the DRw13 haplotypes
    K W Lee
    Department of Microbiology, Georgetown University School of Medicine, Washington, DC 20007
    J Immunol 145:3119-25. 1990
    ....
  101. ncbi The complexity of DRw6 and DR5 haplotypes in American blacks demonstrated by serology, cellular typing, and restriction fragment length polymorphism analysis
    K W Lee
    Department of Microbiology, Georgetown University, Washington, DC
    Hum Immunol 29:202-19. 1990
    ..The serologic and RFLP analyses suggest that some DRw13 and DRw11 haplotypes represent transitional steps between DRw13 and DRw11 in the evolutionary pathway which generated the DRw52 family...

Research Grants62

  1. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..The new knowledge obtained from the proposed experiments challenges the current dogma and will have an impact on our ability to treat patients with active disease and to maintain the patients'quality of life. ..
  2. GENETIC ANALYSIS OF NORMAL AND MALIGNANT LYMPHOCYTES
    Edmond Yunis; Fiscal Year: 1991
    ..These studies will identify the possible involvement of negative regulatory sequences and transacting repressor mechanisms in the stable repression of Class II genes during myelomonocytic cell differentiation...
  3. IMMUNOBIOLOGY OF IA-DETERMINANT & HLA-D INTERACTION
    Elaine Alexander; Fiscal Year: 1992
    ..The information obtained on Ir gene sequences and structure of Ia and T-cell determinants will be valuable in investigating structure-function correlations between specific epitopes and Ir gene products...
  4. GENETICS OF HLA-D AND T-CELL RECEPTOR HAPLOTYPES
    Hugh McDevitt; Fiscal Year: 1991
    ....
  5. DNA METHYLATION, GENE EXPRESSION AND AUTOIMMUNITY
    Bruce Richardson; Fiscal Year: 1992
    ..These studies may help elucidate the pathogenesis of some forms of autoimmunity...
  6. MOLECULAR CLONING OF THE DR7-ASSOCIATED IA GENES
    Robert Karr; Fiscal Year: 1992
    ..The findings of these studies will contribute to the understanding of the diversity of human Ia molecules and the function of immune response genes, which may play important roles in the determination of human health and disease...
  7. TYPE I DIABETES & GENES OF THE HLA-D REGION
    Richard Spielman; Fiscal Year: 1992
    ..Methods of family and population genetic analysis will be used to assess the results statistically...
  8. IMPROVED MATCHING TECHNIQUES IN RENAL TRANSPLANTATION
    FOLKERT BELZER; Fiscal Year: 1980
    ..New developments, both with respect to organ preservation and donor-recipient matching, will be added to the protocols as indicated during the grant...
  9. IMMUNOREGULATORY ROLE OF HUMAN CLASS II MHC MOLECULES
    DAVID ECKELS; Fiscal Year: 1991
    ..In all of these areas, the determinant structures on disease-related antigens and their perhaps subtle interactions with HLA-encoded, class II restriction elements are poorly understood and need explanation...
  10. IMMUNOGENETICS OF SACRAL AGENESIS
    Mark Ballow; Fiscal Year: 1980
    ....
  11. HLA-D AND IA-LIKE ANTIGENS IN RHEUMATOID ARTHRITIS
    Peter Stastny; Fiscal Year: 1980
    ..Families to patients with cutaneous lupus erythematosus will be studied. ..
  12. HLA-D ALLOANTIGENS:RHEUMATOID ARTHRITIS & REPRODUCTIVITY
    J Nelson; Fiscal Year: 1992
    ....
  13. HLA-D POLYMORPHISM AND DISEASE SUSCEPTIBILITY
    John Hansen; Fiscal Year: 1992
    ..These latter experiments may lead to the development of a model for understanding the nature of the immune response involved in the pathogenesis of RA...
  14. MIXED ISOTYPE CLASS II MOLECULES--FUNCTION & OCCURRENCE
    JOHN FREED; Fiscal Year: 1992
    ..This novel form of class II antigens may help to explain certain autoimmune and HLA-D disease associations, particularly those where multiple loci appear to be involved...
  15. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2005
    ..abstract_text> ..
  16. HLA-DR4 HETEROGENEITY-MONOCLONAL ANTIBODIES-ANTIIDIOTYPE
    Soldano Ferrone; Fiscal Year: 1990
    ..The results of these studies will contribute to the characterization of the clinical significance of HLA-DR4 and DQw3 heterogeneity and may suggest novel approaches to treat diseases with autoimmune pathogenesis...
  17. MLR LOCUS TYPING OF CANCER PATIENTS
    Richard Gatti; Fiscal Year: 1980
    ..Several such families have already been typed; however, it is premature to state results. ..
  18. MHC AND CANCER SUSCEPTIBILITY GENES IN MAN
    Richard Gatti; Fiscal Year: 1980
    ..Several such families have already been typed; however, it is premature to state results. ..
  19. RELATIONSHIP OF THE HLA-D REGION TO DISEASE
    Scott Freeman; Fiscal Year: 1990
    ....
  20. GENETIC REGULATION OF HUMAN T-LYMPHOCYTE CLONES
    DAVID ECKELS; Fiscal Year: 1992
    ..Can anti-class II monoclonal antibodies modulate responses to particular viral determinants at either the specificity or functional levels?..
  21. GENETICS & PATHOGENESIS OF INSULIN DEPENDENT DIABETES
    Noel Maclaren; Fiscal Year: 1991
    ..Redox perturbations and superoxide radical generation as a possible common ultimate pathway for beta cell necrosis will be studied in NOD mice and therapeutic manipulations to affect diabetic outcomes attempted...
  22. ISOLATION OF NUCLEIC ACIDS USING SYNTHETIC DNA AS PROBE
    Keiichi Itakura; Fiscal Year: 1980
    ..Various oligonucleotide probes will be synthesized chemically for the screening of the cloned DNA, including beta-2 microglobulin, H-2Kb antigen, HLA-D antigen, PGK, glucagon and others. ..
  23. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
    ..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
  24. H2-O Mediated Antigen Focusing Modulates B Cell Immunity
    LISA DENZIN; Fiscal Year: 2009
    ..The proposed studies will elucidate the role of H2-O in the class II antigen-processing pathway in vivo, during immune responses. These studies are relevant for tumor immunity, autoimmunity and vaccine development. ..
  25. MODULATION OF CLASS II ANTIGEN PROCESSING BY HLA DO
    LISA DENZIN; Fiscal Year: 2003
    ..The proposed work should answer important questions about the role of DO the class II processing pathway and has relevance in such areas as tumor surveillance and autoimmunity. ..
  26. Jo-1-specific T Cell Responses in Polymyositis
    DANA ASCHERMAN; Fiscal Year: 2007
    ..These studies are intended to also provide insight concerning the relative roles of altered T cell repertoire and antigen presentation in the expression of Jo-1+ polymyositis. ..
  27. Individual Housing Data and Socioeconomic Status
    Young Juhn; Fiscal Year: 2007
    ..Telephone interviews will be completed with 1,400 parents of children 1-18 years to obtain additional data. [unreadable] [unreadable]..
  28. Manipulation of immunodominance to promote heterosubtypic immunity to Influenza
    Andrea Sant; Fiscal Year: 2007
    ..Specific Aim 3. Promoting focus of the CD4 T cell responses toward conserved epitopes and protection to virus challenge. [unreadable] [unreadable] [unreadable]..
  29. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  30. Development of a Novel Strategy of Adjuvant Discovery
    David Russell; Fiscal Year: 2009
    ..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
  31. Fine Mapping and Functional Evaluation of Selected Type 1 Diabetes Loci
    Hakon Hakonarson; Fiscal Year: 2009
    ....
  32. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..
  33. Cell Biology of Mycobacterium tuberculosis Infection
    David G Russell; Fiscal Year: 2010
    ..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
  34. Immunobiology of NKT cell development and function
    DEREK B SANT apos ANGELO; Fiscal Year: 2010
    ..Understanding key aspects of iNKT cell development will eventually make it possible to alter the function of these cells using gene therapy approaches in an effort to control cancer and other diseases. ..
  35. Specialized Center of Research in Systemic Lupus Erythe*
    Shu Man Fu; Fiscal Year: 2006
    ..The SCOR continues to represent both inter- and intra-institutional collaboration. It is expected that this interactive approach will continue to provide new insights into the immunological and genetic factors important in SLE. ..
  36. Asthma and Invasive Pneumococcal Disease
    Young Juhn; Fiscal Year: 2006
    ..abstract_text> ..
  37. Ovarian Cancer Detection Using H-NMR_Based Metabonomics
    Kunle Odunsi; Fiscal Year: 2006
    ..The proposed studies may lead to the identification of novel biomarkers for early detection of EOC, that will be evaluated further in prospective studies for early detection of EOC in general and high-risk populations. ..
  38. IMMUNOBIOLOGY OF POSITIVE SELECTION ON SELF PEPTIDES
    DEREK SANT ANGELO; Fiscal Year: 2003
    ..This work will give us insights into phenomenon such as immunodominance and the link between certain MHC alleles and autoimmunity. ..
  39. IMPAIRED TUMOR IMMUNITY DURING H PYLORI INFECTION
    VICTOR REYES; Fiscal Year: 2003
    ..Understanding the molecular basis for the regulation of the local immune response to natural infection will also facilitate the development of therapeutic or prophylactic vaccines against this clinically important pathogen. ..
  40. Augmenting innate and vaccine immune response with der-G
    Daniel Zimmerman; Fiscal Year: 2003
    ..In these studies we will follow survival and ovarian viral titers after intranasal challenge with VV. The studies will also analyze the mechanism of action to identify immune surrogates for use in clinical studies. ..
  41. Peptide Vaccine for Experimental Autoimmune Myocarditis
    Daniel Zimmerman; Fiscal Year: 2003
    ..The effects of J-My-1 administration on the presence and frequency of this cell type will be evaluated. Our goal is to demonstrate that the severity of EAM can be reduced by J-My-1 administration in animals with EAM. ..
  42. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2004
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  43. Regulation of GnRH Neuronal Development by FGF Signaling
    John Gill; Fiscal Year: 2005
    ..Critical stages of GnRH neuron development will be evaluated in mice to discern the functional contribution of FGF signaling in this important neuroendocrine system. ..
  44. Metabolism of M. tuberculosis: New Targets for MDR TB
    David Russell; Fiscal Year: 2004
    ..abstract_text> ..
  45. ROLE OF IL-1 AXIS IN SENSITIZED AIRWAY SMOOTH MUSCLE
    Hakon Hakonarson; Fiscal Year: 2002
    ..We anticipate that the results from our proposed studies will elucidate the role and mechanism of action of the IL-1 axis in the development of the "pro-asthmatic" ASM phenotype. ..
  46. Prevention of Diabetes with Lipid Immunomodulators
    Teresa Dilorenzo; Fiscal Year: 2005
    ....
  47. Selective Presentation of Autoantigens by B Cells
    Andrea Sant; Fiscal Year: 2005
    ..Test whether antigen-specific B cells display potentiated ability to present autoantigenic self peptides. Specific Aim 4. Test the effect of B cell antigen presentation in vivo on breaking of self tolerance to autoantigens. ..
  48. derG Immunostimulant Prevention/Treatment of HSV Disease
    Daniel Zimmerman; Fiscal Year: 2003
    ..An integral part of the phase II program will be to further elucidate the target cells and mechanism of action of derG. ..
  49. TAP-1/E7 INTERACTION: ROLE IN RESPIRATORY PAPILLOMAS
    Andrea Vambutas; Fiscal Year: 2004
    ..To determine whether the interaction between TAP-1 and E7 in naturally occurring infections sufficient to result in a loss of peptide transport and whether this loss correlates with viral protein load and the patients clinical course. ..
  50. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  51. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..Tests may also be developed to monitor destructive T cell activity in patients undergoing treatment, so that doctors will be able to know if the treatments are working. [unreadable] [unreadable] [unreadable]..
  52. SIALOADENITIS IN AG INDUCED AND SPONTANEOUS AUTOIMMUNITY
    Shu Man Fu; Fiscal Year: 2002
    ..In the fourth specific aim, B-less mice which are congenic with the sialoadenitis susceptible strains will be generated to explore the role of B cells in both the spontaneous and antigen-induced autoimmune model. ..