histocompatibility antigens class ii

Summary

Summary: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

Top Publications

  1. ncbi How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
  2. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
  3. ncbi Primary antitumor immune response mediated by CD4+ T cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, 0027 Oslo, Norway
    Immunity 22:371-83. 2005
  4. pmc Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
    C Thery
    Institut National de la Sante et de la Recherche Medicale, U520, Institut Curie, 75005 Paris, France
    J Cell Biol 147:599-610. 1999
  5. ncbi Natural selection at major histocompatibility complex loci of vertebrates
    A L Hughes
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Annu Rev Genet 32:415-35. 1998
  6. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
  7. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
  8. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
  9. ncbi Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, Bonn, Germany
    Science 316:612-6. 2007
  10. pmc The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain
    Daniel R Beisner
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    J Exp Med 210:23-30. 2013

Research Grants

  1. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
  2. Role of Elastolytic Cathepsins in Emphysema
    Harold A Chapman; Fiscal Year: 2010
  3. Down-regulation of MHC class l molecules by HCMV US2
    Domenico Tortorella; Fiscal Year: 2009
  4. Construction of safe and effective live tuberculosis vaccines
    Steven A Porcelli; Fiscal Year: 2013
  5. MHC Class II Antigen Processing and Immune Recognition of Melanoma
    KAREN TARASZKA HASTINGS; Fiscal Year: 2011
  6. Poxvirus Modulation of Immune Responses
    Janice S Blum; Fiscal Year: 2010
  7. Inhibition of Antigen Presentation in Multiple Sclerosis
    Kai W Wucherpfennig; Fiscal Year: 2012
  8. Pathways of Antigen Presentation by CD1
    Michael B Brenner; Fiscal Year: 2013
  9. Generation and Evaluation of Pro-Apoptotic rBCG and Viral Vectors as TB Vaccine C
    Thomas Evans; Fiscal Year: 2012
  10. Structural Studies of IgE Receptors
    Theodore S Jardetzky; Fiscal Year: 2010

Detail Information

Publications303 found, 100 shown here

  1. ncbi How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
    ..Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs...
  2. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  3. ncbi Primary antitumor immune response mediated by CD4+ T cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, 0027 Oslo, Norway
    Immunity 22:371-83. 2005
    ..These data indicate a mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4+ T cells through collaboration with macrophages...
  4. pmc Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
    C Thery
    Institut National de la Sante et de la Recherche Medicale, U520, Institut Curie, 75005 Paris, France
    J Cell Biol 147:599-610. 1999
    ..Thus, DC-derived exosomes accumulate a defined subset of cellular proteins reflecting their endosomal biogenesis and accounting for their biological function...
  5. ncbi Natural selection at major histocompatibility complex loci of vertebrates
    A L Hughes
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Annu Rev Genet 32:415-35. 1998
    ..d) Introns have been homogenized relative to exons over evolutionary time, suggesting that balancing selection acts to maintain diversity in the latter, in contrast to the former...
  6. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
    ..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
  7. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  8. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  9. ncbi Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, Bonn, Germany
    Science 316:612-6. 2007
    ..These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis...
  10. pmc The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain
    Daniel R Beisner
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    J Exp Med 210:23-30. 2013
    ..Moreover, these data suggest that modulation of Sppl2a may be a useful therapeutic strategy for treatment of B cell dependent autoimmune disorders...
  11. pmc B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A
    Hannes Bergmann
    Ramaciotti Immunization Genomics Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2600, Australia
    J Exp Med 210:31-40. 2013
    ..The findings illuminate an important role for the final step in the CD74-MHC II pathway and a new target for protease inhibitor treatment of B cell diseases...
  12. ncbi Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
    H Lue
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Oncogene 26:5046-59. 2007
    ..Thus, MIF can directly promote cell survival through activation of the PI3K/Akt pathway and this effect is critical for tumor cell survival...
  13. ncbi Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
    T Miyazaki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, France
    Cell 84:531-41. 1996
    ..Peripheral T cells reacted strongly to splenocytes from syngeneic wild-type mice, no doubt reflecting the unique peptide complement carried by class II molecules in mutant animals...
  14. ncbi Antigen presentation and T cell development in H2-M-deficient mice
    W P Fung-Leung
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Science 271:1278-81. 1996
    ..Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells...
  15. pmc Mature dendritic cells use endocytic receptors to capture and present antigens
    Craig D Platt
    Department of Cell Biology, Ludwig Institute for Cancer Research, and Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 107:4287-92. 2010
    ....
  16. ncbi Enhancing immunity through autophagy
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, CH 8057 Zurich, Switzerland
    Annu Rev Immunol 27:423-49. 2009
    ..These immune-enhancing functions make autophagy an attractive target for therapeutic manipulation in human disease...
  17. ncbi Human TCR-binding affinity is governed by MHC class restriction
    David K Cole
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Immunol 178:5727-34. 2007
    ....
  18. pmc Mice lacking all conventional MHC class II genes
    L Madsen
    Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 96:10338-43. 1999
    ..Therefore, they should be invaluable for engineering "humanized" mouse models of human MHC-II-associated autoimmune disorders...
  19. ncbi Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B
    H Li
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville 20850, USA
    Immunity 9:807-16. 1998
    ..This variability can account for the preferential expression of certain V alpha regions among T cells reactive with SEB...
  20. pmc MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation
    Aude de Gassart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 105:3491-6. 2008
    ..MARCH I is, therefore, a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs...
  21. pmc The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
    Janna Schneppenheim
    Biochemical Institute, Christian Albrechts University of Kiel, D 24118 Kiel, Germany
    J Exp Med 210:41-58. 2013
    ....
  22. pmc MHC class II tetramers
    Gerald T Nepom
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 188:2477-82. 2012
    ..Translational opportunities for immune disease monitoring are driving the rapid development of HLA class II tetramer use in clinical applications, together with innovations in tetramer production and epitope discovery...
  23. ncbi Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy
    Falk Nimmerjahn
    Klinische Kooperationsgruppe, GSF Institut für Klinische Molekularbiologie, Munich, Germany
    Eur J Immunol 33:1250-9. 2003
    ..These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy...
  24. ncbi Association between anal sac gland carcinoma and dog leukocyte antigen-DQB1 in the English Cocker Spaniel
    J Aguirre-Hernandez
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Tissue Antigens 76:476-81. 2010
    ....
  25. ncbi Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 168:763-70. 2002
    ....
  26. ncbi HLA class I and II polymorphisms in Mexican Mestizo patients with dengue fever
    Jorge Abelardo Falcón-Lezama
    Arboviruses Department, Center for Research in Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Acta Trop 112:193-7. 2009
    ..012, p(c)=NS, OR=7.0, 95%CI=1.11-73.8). We identified possible associations of HLA-B and HLA-DQB1 alleles with the risk of developing symptomatic disease, DF and DHF in a Mexican Mestizo population...
  27. ncbi Evolutionary patterns of MHC class II B in owls and their implications for the understanding of avian MHC evolution
    Reto Burri
    Laboratory for Conservation Biology, Department of Ecology and Evolution, Biophore, University of Lausanne, Lausanne, Switzerland
    Mol Biol Evol 25:1180-91. 2008
    ..The owl MHC thus opens new perspectives for a more comprehensive understanding of avian MHC evolution...
  28. pmc A statistical method for predicting classical HLA alleles from SNP data
    Stephen Leslie
    Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
    Am J Hum Genet 82:48-56. 2008
    ....
  29. ncbi Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study
    Rakina Yaneva
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biopolymers 91:14-27. 2009
    ....
  30. ncbi Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells
    J L Pooley
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 166:5327-30. 2001
    ..This differential persisted when the DC were activated with LPS. The CD8(+) DC are therefore specialized for in vivo cross-presentation of exogenous soluble Ags into the class I MHC presentation pathway...
  31. ncbi Cell biology of antigen processing in vitro and in vivo
    E Sergio Trombetta
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Annu Rev Immunol 23:975-1028. 2005
    ..How dendritic cells handle antigens is likely to be as important a determinant of immunogenicity and tolerance as is the nature of the antigens themselves...
  32. ncbi Altered antigen presentation in mice lacking H2-O
    M Liljedahl
    The R W Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA
    Immunity 8:233-43. 1998
    ..This effect may serve to decrease the presentation of antigens internalized by fluid-phase endocytosis, thus concentrating the B cell-mediated antigen presentation to antigens internalized by membrane immunoglobulin...
  33. ncbi Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size
    R M Chicz
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 358:764-8. 1992
    ....
  34. ncbi Defective antigen processing in GILT-free mice
    M Maric
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 294:1361-5. 2001
    ..The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail...
  35. pmc Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    Dorothee Schmid
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Immunity 26:79-92. 2007
    ..We suggest that macroautophagy constitutively and efficiently delivers cytosolic proteins for MHC class II presentation and can be harnessed for improved helper T cell stimulation...
  36. pmc A vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice transgenic to multiple common HLA class II molecules
    Susan Pereira Ribeiro
    Laboratory of Clinical Immunology and Allergy LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    PLoS ONE 5:e11072. 2010
    ..The vaccine may thus be a source of cognate help for HIV-specific CD8+ T cells elicited by conventional immunogens, in a wide proportion of vaccinees...
  37. pmc 454 sequencing reveals extreme complexity of the class II Major Histocompatibility Complex in the collared flycatcher
    Magdalena Zagalska-Neubauer
    Institute of Environmental Sciences, Jagiellonian University, Krakow, Poland
    BMC Evol Biol 10:395. 2010
    ..In such complex systems, understanding of the evolutionary patterns and their causes has been limited due to challenges posed by genotyping...
  38. ncbi The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance
    Christopher A Lazarski
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Immunity 23:29-40. 2005
    ..Taken collectively, our results suggest the half-life of class II:peptide complexes is the primary parameter that dictates the ultimate hierarchy of the elicited T cell response...
  39. pmc Editing of the HLA-DR-peptide repertoire by HLA-DM
    H Kropshofer
    German Cancer Research Center, Department of Molecular Immunology, Heidelberg, Germany
    EMBO J 15:6144-54. 1996
    ....
  40. ncbi Mice lacking MHC class II molecules
    D Cosgrove
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 66:1051-66. 1991
    ..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
  41. ncbi Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3050, Australia
    Nat Immunol 9:1244-52. 2008
    ..As the antigen-presenting abilities of cDCs and pDCs are fundamentally distinct, these two cell types may activate largely nonoverlapping repertoires of CD4(+) T cells...
  42. ncbi Diversifying and purifying selection in the peptide binding region of DRB in mammals
    Rebecca F Furlong
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Mol Evol 66:384-94. 2008
    ....
  43. ncbi MHC II and the endocytic pathway: regulation by invariant chain
    O J B Landsverk
    Centre for Immune Regulation, Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway
    Scand J Immunol 70:184-93. 2009
    ..Ii then transports the nascent MHC II to more or less specialized compartment where they can load peptides derived from internalized pathogens...
  44. pmc A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population
    Denise M McKinney
    La Jolla Institute for Allergy and Immunology, La Jolla, San Diego, CA 92037, USA
    Immunogenetics 65:357-70. 2013
    ..This panel of lines will enable high throughput determination of HLA restriction, enabling better characterization of HLA class II-restricted T cell responses and facilitating the development of HLA tetrameric staining reagents...
  45. ncbi Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    Casper Paludan
    Laboratory of Viral Immunobiology, Rockefeller University, New York, NY 10021, USA
    Science 307:593-6. 2005
    ..Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease...
  46. ncbi Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo
    Arya Biragyn
    Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 104:1961-9. 2004
    ....
  47. ncbi Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells
    Ying Wang
    Centre d immunologie de Marseille Luminy, INSERM CNRS, Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Marseille Cedex 09, France
    J Immunol 180:1565-75. 2008
    ..Therefore, despite the presence of autoantibodies causative of severe systemic disease, the pathological conditions observed in Lat(Y136F) mice unfold in an Ag-independent manner and thus do not qualify as a genuine autoimmune disorder...
  48. ncbi Cutting edge: MHC class II-restricted killing in vivo during viral infection
    Evan R Jellison
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:614-8. 2005
    ..In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets...
  49. ncbi Genetic control of MHC class II expression
    Jenny Pan Yun Ting
    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 109:S21-33. 2002
    ..The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression...
  50. ncbi Activation of lysosomal function during dendritic cell maturation
    E Sergio Trombetta
    Department of Cell Biology and Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 8002, USA
    Science 299:1400-3. 2003
    ..Lysosomal function in DCs thus appears to be specialized for the developmentally regulated processing of internalized antigens...
  51. ncbi The wide diversity and complexity of peptides bound to class II MHC molecules
    Anish Suri
    Washington University School of Medicine, Department of Pathology and Immunology, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Immunol 18:70-7. 2006
    ....
  52. pmc DNA vaccine that targets hemagglutinin to MHC class II molecules rapidly induces antibody-mediated protection against influenza
    Gunnveig Grodeland
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo 0027, Norway
    J Immunol 191:3221-31. 2013
    ..These results suggest that MHC II-targeted DNA vaccines could play a role in situations of pandemic threats. The vaccine principle should be extendable to other infectious diseases. ..
  53. pmc Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes
    Reza Abdi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1759-67. 2008
    ....
  54. pmc Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes
    Alice O Kamphorst
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Immunol 185:3426-35. 2010
    ..Our observations have significant implications for understanding initiation of immune responses and vaccination strategies targeting DCs and activated monocytes...
  55. ncbi The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival
    Idit Shachar
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Leuk Lymphoma 52:1446-54. 2011
    ..One such agent, the monocolonal antibody milatuzumab directed at CD74, is already being studied in early clinical trials...
  56. ncbi Presentation of acquired peptide-MHC class II ligands by CD4+ regulatory T cells or helper cells differentially regulates antigen-specific CD4+ T cell response
    Gang Zhou
    Cancer Immunotherapy Program, Medical College of Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 186:2148-55. 2011
    ..These findings implicate trogocytosis in different subsets of CD4(+) T cells as an intrinsic mechanism for the fine tuning of Ag-specific CD4(+) T cell response...
  57. pmc The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway
    Monika Sarah E D Schulze
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Curr Opin Immunol 24:105-11. 2012
    ..There are significant similarities to the peptide loading process for MHC class I molecules, even though it is executed by a distinct set of proteins in a different cellular compartment...
  58. pmc Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase
    Huapeng Fan
    Department of Medicine, Centre for Inflammatory Diseases, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    J Immunol 186:4915-24. 2011
    ..These data demonstrate that MIF and CD74 play previously unappreciated roles in CCL2-induced macrophage adhesion and migration, and they indicate that MIF and CD74 mediate this effect via both common and independent mechanisms...
  59. pmc Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection
    David K Cole
    Institute of Infection and Immunity, Cardiff University School of Medicine, The Henry Wellcome Building, Cardiff CF14 4XN, Wales, UK
    Nat Commun 3:665. 2012
    ....
  60. ncbi Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifies HLA-DOA mRNA as a prognostic factor for survival
    Yuri Souwer
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academical Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Br J Haematol 145:334-43. 2009
    ..Multivariate analysis revealed that the prognostic value of DOA mRNA was independent of the mutational status of the IGHV genes. Thus, aberrant transcription of DOA forms a novel and additional prognostic indicator for survival in B-CLL...
  61. pmc Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens
    Jun Ma
    Division of Immunology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 287:34149-56. 2012
    ....
  62. pmc Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Gastroenterology 140:2019-30. 2011
    ..We studied CMF suppressive capacity and evaluated the ability of CMF to induce Treg cells...
  63. ncbi Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response
    Matthew D Woolard
    Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:2065-74. 2007
    ..From these data, we conclude that F. tularensis can alter host T cell responses by causing macrophages to produce PGE(2). This study defines a previously unknown mechanism used by F. tularensis to modulate adaptive immunity...
  64. pmc c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74
    Maya Gordin
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 185:2020-31. 2010
    ..Thus, the CD74-HGF/c-Met axis defines a novel physiologic survival pathway in mature B cells, resulting in the control of the humoral immune response...
  65. pmc Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma
    Lapo Alinari
    Division of Hematology, Department of Medicine, College of Medicine, The Ohio State University, Columbus, USA
    Blood 117:4530-41. 2011
    ..Significant in vivo therapeutic activity of combination rituximab and milatuzumab was demonstrated in a preclinical model of MCL. These data support clinical evaluation of combination milatuzumab and rituximab therapy in MCL...
  66. ncbi In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S
    Marianne Boes
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 35:2552-62. 2005
    ..Proper degradation of Ii is thus essential for normal endosomal morphology in antigen-presenting cells in vivo...
  67. pmc TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner
    Inbal Binsky
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Immunol 184:4761-9. 2010
    ..These results could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival...
  68. pmc Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells
    Eddie W Adams
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immununology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Chembiochem 9:294-303. 2008
    ..Taken together, our data suggest that a DC targeting strategy that is based upon carbohydrate-lectin interactions is a promising approach for enhancing antigen presentation via class I and class II molecules...
  69. ncbi HLA class II allele and haplotype frequencies in Koreans based on 107 families
    E Y Song
    Seoul National University College of Medicine, Korea
    Tissue Antigens 59:475-86. 2002
    ..The results obtained in this study will provide useful information for anthropology, organ transplantation and disease association studies...
  70. pmc Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanoma
    Paul F Robbins
    Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B42, Bethesda, MD 20892 7502, USA
    J Immunol 169:6036-47. 2002
    ..These observations provide an impetus to develop strategies directed toward generating HLA class II-restricted tumor-reactive T cells...
  71. ncbi Viral strategies of immune evasion
    H L Ploegh
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 280:248-53. 1998
    ....
  72. ncbi Upregulation of major histocompatibility complex class II antigens in hepatocytes in Doberman hepatitis
    M Speeti
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, P O Box 57, 00014 Helsinki, Finland
    Vet Immunol Immunopathol 96:1-12. 2003
    ..Inappropriate MHC class II expression in hepatocytes and mononuclear cell infiltration are suggesting an autoimmune nature for chronic hepatitis in Dobermans...
  73. ncbi Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment
    Rene Maehr
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Eur J Immunol 34:2230-6. 2004
    ..We suggest that neither Ii itself, nor the MHC class II products are required for normal B cell development...
  74. pmc Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans
    You Jeong Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Exp Med 207:237-46. 2010
    ..These findings define a novel human CD4+ T cell subset that develops via an MHC class II-dependent T-T interaction...
  75. pmc Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor
    Michael Hahn
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:490-6. 2005
    ..This topology reduces the interaction surface with peptide and alters the geometry for CD4 association. We propose that unusual TCR-binding properties can permit autoreactive T cells to escape deletion...
  76. ncbi Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins
    Ida E Andersson
    Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    Org Biomol Chem 8:2931-40. 2010
    ..This work contributes to the development of an altered glycopeptide for inducing immunological tolerance in CIA, with the long-term goal of developing a therapeutic vaccine for treatment of RA...
  77. ncbi Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells
    Honorio Torres-Aguilar
    Department of Molecular Biomedicine, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico City, Mexico
    J Immunol 184:1765-75. 2010
    ..CD39 was highly expressed only in tDC-TGF, which correlated with increased adenosine production. We propose that these molecules, together with IL-10 and prostanoids, are key factors to induce Ag-specific tolerance in memory T cells...
  78. pmc Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation
    Eleni Zika
    Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 23:3091-102. 2003
    ....
  79. pmc Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells
    Even Walseng
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:20465-70. 2010
    ..Thus, the cellular distribution and stability of surface pMHC-II in DCs is regulated by ubiquitin-dependent degradation of internalized pMHC-II...
  80. ncbi MHC polymorphism and disease resistance to Vibrio anguillarum in 12 selective Japanese flounder (Paralichthys olivaceus) families
    Tian Jun Xu
    Key Lab for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China
    Fish Shellfish Immunol 25:213-21. 2008
    ..The disease resistance-related MHC markers could be used for molecular marker-assisted selective breeding in the flounder...
  81. ncbi Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus
    T Nakagawa
    Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Science 280:450-3. 1998
    ..The identification of a protease involved in class II presentation in a tissue-specific manner suggests a potential means of manipulating CD4+ T cell responsiveness in vivo...
  82. ncbi MHC class II/CD38/CD9: a lipid-raft-dependent signaling complex in human monocytes
    Marie Thérèse Zilber
    Institut National de la Santé et de la Recherche Médicale INSERM U662, and Service Commun d Imagerie, Institut d Hematologie, Hopital SaintLouis, Paris, France
    Blood 106:3074-81. 2005
    ..Together, these observations demonstrate the presence of a CD38 and HLA-DR signaling complex within tetraspanin-containing lipid rafts and the functional impact of their molecular partner CD9 in antigen presentation...
  83. ncbi The genomic sequence and analysis of the swine major histocompatibility complex
    C Renard
    LREG INRA CEA, Jouy en Josas, France
    Genomics 88:96-110. 2006
    ..We show that the centromere insertion has occurred within a cluster of BTNL genes located at the boundary of the class II and III regions, which might have resulted in the loss of an orthologue to human C6orf10 from this region...
  84. ncbi DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cells
    Agnete B Fredriksen
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, Sognsvannsvn 20, 0027 Oslo, Norway
    Mol Ther 13:776-85. 2006
    ..Targeting to APC was essential for these effects. The results show that immunogenicity of plasmid DNA vaccines can be increased by inducing muscle to secrete proteins that target antigen to APC...
  85. pmc Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
    M van Ham
    Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Exp Med 191:1127-36. 2000
    ..DO may serve to increase the threshold for nonspecific B cell activation, restricting class II-peptide binding to late endosomal compartments, thereby affecting the peptide repertoire...
  86. pmc Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
    R M Hershberg
    Virginia Mason Research Center, Seattle, Washington 98101, USA
    J Clin Invest 102:792-803. 1998
    ....
  87. ncbi Determination of the HLA-DM interaction site on HLA-DR molecules
    R C Doebele
    School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Immunity 13:517-27. 2000
    ..In vitro, these mutant DR3 molecules were resistant to DM-catalyzed CLIP release and showed reduced binding to DM. All mutations localize to a single lateral face of HLA-DR, which we propose interacts with DM during peptide exchange...
  88. ncbi The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
    P Ghosh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 378:457-62. 1995
    ..The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM...
  89. pmc CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation
    Lina E Tze
    Immunology Department, John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    J Exp Med 208:149-65. 2011
    ..Exploiting this posttranslational pathway for boosting MHC class II and CD86 expression on DCs may provide an opportunity to enhance the immunogenicity of vaccines...
  90. ncbi MHC class II expression identifies functionally distinct human regulatory T cells
    Clare Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4622-31. 2006
    ..Thus, the direct ex vivo expression of MHC-II in the context of CD25(high) identifies a mature, functionally distinct regulatory T cell population involved in contact-dependent in vitro suppression...
  91. pmc Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence
    Woelsung Yi
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Clin Invest 120:1324-36. 2010
    ..These studies show that DO expression can shape the overall MHCII self-peptide repertoire to promote T cell tolerance...
  92. ncbi Mannose receptor-targeted vaccines
    Tibor Keler
    Medarex, Inc, 519 Route 173 West, Bloomsbury, NJ 08804, USA
    Expert Opin Biol Ther 4:1953-62. 2004
    ....
  93. ncbi Routes to manipulate MHC class II antigen presentation
    Tineke van den Hoorn
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands
    Curr Opin Immunol 23:88-95. 2011
    ..We will discuss past, present and future of these insights into the biology of MHC-II...
  94. ncbi Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins
    M J Mamula
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 274:22321-7. 1999
    ..Isoaspartyl linkages within proteins are enhanced in aging and stressed cells and arise under physiological conditions. These post-translationally modified peptides may serve as an early immunologic stimulus in autoimmune disease...
  95. ncbi A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells
    Jim Xiang
    Research Unit, Saskatchewan Cancer Agency, Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Immunol 174:7497-505. 2005
    ..These results have substantial implications for research in antitumor and other aspects of immunity...
  96. pmc Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi
    A B Reis
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Departamento de Análises Clínicas Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil
    Clin Exp Immunol 146:303-11. 2006
    ..Higher levels of circulating T lymphocytes (both CD4(+) and CD8(+) T cells) and lower MHC-II expression by peripheral blood lymphocytes seem to be the key for the effective immunological response, a hallmark of asymptomatic CVL...
  97. ncbi MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse
    Elizabeth M Hiltbold
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:1329-38. 2003
    ..We propose that T cell activation is facilitated by recruitment of MHC class II-peptide complexes to the immunological synapse by virtue of their constitutive association with lipid raft microdomains...
  98. ncbi Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera
    Sofia Casares
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Immunol 3:383-91. 2002
    ..Soluble dimeric pMHC class II may be useful in the development of immunospecific therapies for type 1 diabetes...
  99. pmc Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection
    C Jenkins
    Centre for Virus Research, Westmead Millennium Institute, P O Box 412, Westmead, NSW 2145, Australia
    J Virol 82:3736-50. 2008
    ..As GM-Ps and monocytes support latent infection, expression of LAcmvIL-10 may enable HCMV to avoid immune recognition and clearance during latency...
  100. pmc Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response
    Ramon Arens
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:6472-6. 2008
    ..In total, this study reveals that the MCMV-specific CD4 T cell response is complex and functionally diverse, highlighting its important role in controlling this persistent pathogen...
  101. ncbi Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness
    Andrew Godkin
    Cellular Immunology and Vaccine Development Group, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Hepatology 41:1383-90. 2005
    ....

Research Grants63

  1. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..The new knowledge obtained from the proposed experiments challenges the current dogma and will have an impact on our ability to treat patients with active disease and to maintain the patients'quality of life. ..
  2. Role of Elastolytic Cathepsins in Emphysema
    Harold A Chapman; Fiscal Year: 2010
    ..Identification of biomarkers of cathepsin S activity in COPD patients could :erve as a surrogate for disease progression and an in vivo measure of efficacy during drug trials. ..
  3. Down-regulation of MHC class l molecules by HCMV US2
    Domenico Tortorella; Fiscal Year: 2009
    ..A full understanding of how HCMV US2 manipulates the cellular machinery of the host to prevent MHC class I and class II antigen presentation may permit the design of pharmaceutical agents that block US2 function. ..
  4. Construction of safe and effective live tuberculosis vaccines
    Steven A Porcelli; Fiscal Year: 2013
    ..The information gained will be applied to the design and construction of better vaccines for the prevention of tuberculosis. ..
  5. MHC Class II Antigen Processing and Immune Recognition of Melanoma
    KAREN TARASZKA HASTINGS; Fiscal Year: 2011
    ..The long-term goal of these studies is to aid the development of effective immunotherapy for melanoma. ..
  6. Poxvirus Modulation of Immune Responses
    Janice S Blum; Fiscal Year: 2010
    ..These research projects will be supported by an administrative core, and two research facilities including a virus core and a pulmonary biology core, each designed to facilitate studies of viral pathogenesis and host immunity...
  7. Inhibition of Antigen Presentation in Multiple Sclerosis
    Kai W Wucherpfennig; Fiscal Year: 2012
    ..We have discovered small molecules that substantially accelerate peptide binding to MHC class II molecules and will now examine their mechanism of action as well as therapeutic applications in humanized mouse models of MS. ..
  8. Pathways of Antigen Presentation by CD1
    Michael B Brenner; Fiscal Year: 2013
    ..Further, we determine what regulates the process of how cells kill microbes by fusing the vesicles containing the organisms with vesicles that contain factors that can destroy the infections agents. ..
  9. Generation and Evaluation of Pro-Apoptotic rBCG and Viral Vectors as TB Vaccine C
    Thomas Evans; Fiscal Year: 2012
    ..We will evaluate these regimens in mice and rhesus macaques, models of TB vaccine immunology and efficacy with which we have extensive experience, to expediently select an optimal regimen. ..
  10. Structural Studies of IgE Receptors
    Theodore S Jardetzky; Fiscal Year: 2010
    ..abstract_text> ..
  11. Roles for Exosomes in Adaptive Immunity to M. tuberculosis
    Pamela A Wearsch; Fiscal Year: 2013
    ..These studies may also serve as a foundation for the future development of exosome-based diagnostics and therapeutics. ..
  12. Cell Free System for Identification of MHC Class II Immunodominant Epitopes
    Scheherazade Sadegh-Nasseri; Fiscal Year: 2011
    ..Thus, the new technology proposed in this project takes a major leap forward in predicting accurately immunodominant peptides. Project ..
  13. CLASS II ANTIGEN PRESENTATION VIA CHAPERONE MEDIATED AUTOPHAGY
    Janice S Blum; Fiscal Year: 2013
    ..These studies may also be important in understanding autoimmunty, and lead to new approaches for vaccine development. ..
  14. Functional analyses of antiviral CD4+ T cell responses
    J Lindsay Whitton; Fiscal Year: 2013
    ..Might IFN[unreadable] be the "link" by which CD4+ T cells help the development of CD8+ T cell memory? Is the role of IFN[unreadable] the same for specific &non-specific CD4+ helper T cells? ..
  15. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..While this may be a high risk project, the yield, if shown to work, even as a method to enhance mammalian cell delivery of proteins, should have a significant impact. ..
  16. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh-Nasseri; Fiscal Year: 2013
    ..Hence, knowledge of the identity of immunodominant epitopes, and a clear understanding of how they are generated inside cells, can guide the design of effective immunotherapeutics. ..
  17. Molecular Mechanisms of HLA-DO in Antigen Processing
    Scheherazade Sadegh-Nasseri; Fiscal Year: 2013
    ..A clear understanding of HLA-DO function and its role in antigen processing and the selection of immunodominant epitopes, can guide the design of effective immunotherapeutics. ..
  18. MOLECULAR CLONING OF HLA CLASS II TUMOR ANTIGENS
    Dorothee Herlyn; Fiscal Year: 2000
    ..The antigens also may be of diagnostic value. ..
  19. MOLECULAR CLONING OF HLA CLASS II TUMOR ANTIGENS
    Dorothee Herlyn; Fiscal Year: 2003
    ..The antigens also may be of diagnostic value. ..
  20. Effect of recipient age /graft vs host disease post BMT
    RAYMOND HUTCHISON; Fiscal Year: 2001
    ..abstract_text> ..
  21. PLATELET STREPTOCOCCAL INTERACTIONS IN ENDOCARDITIS
    MARK HERZBERG; Fiscal Year: 1992
    ..Adhesion of this bacterium to damaged intracardiac tissues may promote colonization and infection. In addition, S. sanguis may trigger thrombotic growth of the vegetation and thromboembolic sequellae of SBE...
  22. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 1991
    ..These studies should help define mucosal barrier defects in newborns and help explain the pathogenesis of neonatal diseases such as necrotizing enterocolitis, toxigenic diarrhea and food allergy...
  23. SALMONELLA TYPE 3 SECRETION SYSTEM FOR ANTIGEN DELIVERY
    JORGE GALAN; Fiscal Year: 2004
    ..This will significantly broaden the utility of avirulent strains of Salmonella as platforms for the development of polyvalent vaccines. ..
  24. MELANOSOME PROTEIN SORTING, FOLDING & ANTIGEN PROCESSING
    Michael Marks; Fiscal Year: 2002
    ..The effect of altering the protein sorting and/or retention properties of tyrosinase and gp100 on recognition by specific T cell clones will be determined. ..
  25. TRANSPLANTATION OF ALLOGENEIC SKIN EQUIVALENTS
    Barbara Hull; Fiscal Year: 1993
    ..A better understanding of the role of the keratinocyte in graft rejection should improve the techniques for skin expansion of the in vitro...
  26. A HLA Mouse Model for Gluten Sensitivity and Enteropathy
    Joseph Murray; Fiscal Year: 2009
    ..abstract_text> ..
  27. Functional Analysis of HCV-B Lymphocyte Interactions
    Thomas Chambers; Fiscal Year: 2003
    ..abstract_text> ..
  28. REGULATION OF MACROPHAGE INFLAMMATORY FUNCTIONS BY CSF
    Robert Moore; Fiscal Year: 1990
    ..Lastly, CSFs from EL-4 thymoma cells and P388D1 macrophage cells will be compared with CSF-1 from fibroblasts (L929) for their relative efficiencies in stimulating functional activities of macrophages...
  29. Induction of Tolerance to Allografts
    Anthony Monaco; Fiscal Year: 2004
    ..abstract_text> ..
  30. INTERFERON REGULATORY FACTOR 2 FUNCTIONS
    George Blanck; Fiscal Year: 2002
    ..If so, this would be the first demonstration of a role for IRF-2 mutations in human tumor. Methods: EMSA, in vivo footprinting, DNA transfection, DNA sequencing, DNA cloning. ..
  31. REGULATION OF MHC CLASS II EXPRESSION IN TROPHOBLAST
    Shawn Murphy; Fiscal Year: 2001
    ..These studies will provide the first step in understanding the biological consequences of trophoblastic expression of class II antigens to successful pregnancy. ..
  32. CONTROL OF IA ANTIGEN EXPRESSION
    SANTA ONO; Fiscal Year: 1999
    ..1 and its gene will contribute to our understanding of the biology of class II MHC gene regulation, and will form the foundation for future strategies to use NFX.1 in targeted immunomodulation. ..
  33. BIOLOGY OF HUMAN TUMOR INFILTRATING LYMPHOCYTES
    Charles Balch; Fiscal Year: 1991
    ....
  34. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  35. MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIA
    Debasish Sinha; Fiscal Year: 2004
    ..Microglia form the first line of defense during infection in the CNS and are involved in various immune diseases including AIDS. ..
  36. SYNGENEIC MIXED LYMPHOCYTE INTERACTIONS IN MICE
    JACKSON SMITH; Fiscal Year: 1980
    ....
  37. EXPRESSION & FUNCTION OF HLA ANTIGEN ON CARDIAC MYOCYTES
    Aftab Ansari; Fiscal Year: 1990
    ....
  38. IMMUNE MECHANISMS OF TRANSPLANT REJECTION AND TOLERANCE
    Jenny Ting; Fiscal Year: 2000
    ..Together, these three projects address different aspects of induction tolerance to two specific cellular transplants. Significant collaborations and synergy are planned. ..
  39. ROLE OF MACROPHAGE SIALOPHORIN (CD43) IN HIV DEFENSE
    EILEEN REMOLD O DONNELL; Fiscal Year: 1992
    ..Finally, we will determine whether CD43 plays a role in the binding and uptake of HIV by monocyte...
  40. PROCESSING OF ANTIGENS FOR HLA RESTRICTED PRESENTATION
    Elizabeth Mellins; Fiscal Year: 1999
    ....
  41. OCULAR CELLS IN THE ACTIVATION OF IMMUNITY & SUPPRESSION
    Richard Granstein; Fiscal Year: 1990
    ..Thus, a search for immunologic modulators produced by OC Is warranted. Elucidation of the mechanisms of immunologic privilege of the eye might have currently unforseen therapeutic implications, particularly in allotransplantation...
  42. CLASS II HLA ANTIGENS IN THE AQUEOUS OUTFLOW SYSTEM
    Mary Lynch; Fiscal Year: 1992
    ..We will refine our experimental model of glaucoma in the mouse and rat eye and use this model to explore the importance of aqueous drainage to the development of ACAID...
  43. MIXED ISOTYPE CLASS II MOLECULES--FUNCTION & OCCURRENCE
    JOHN FREED; Fiscal Year: 1992
    ..This novel form of class II antigens may help to explain certain autoimmune and HLA-D disease associations, particularly those where multiple loci appear to be involved...
  44. HIV Vaccines that Elicit Immune Responses to Virus Env
    Catarina E Hioe; Fiscal Year: 2010
    ..These studies will provide information about how to design more immunogenic forms of gp120, how to better stimulate gp120-specific CD4 T cell responses, and how to use the mutated gp120 constructs as HIV vaccines. ..
  45. MHC CLASS II INDUCTION IN ALLOGRAFT REJECTION
    Dilip Kittur; Fiscal Year: 1993
    ..This knowledge may be applied in the future to reduce immunogenicity of an allograft to circumvent rejection...
  46. CIITA REGULATION IN B LYMPHOCYTES AND MULTIPLE MYELOMA
    Kenneth Wright; Fiscal Year: 2003
    ..He also proposes to clone and characterize one of these factors using the yeast one-hybrid system or oligonucleotide screening of phage expression libraries. ..
  47. IMMUNE FUNCTION IN ALLERGIC ENCEPHALOMYELITIS
    Robert Fritz; Fiscal Year: 2003
    ..1+ alpha/beta+ T cells by spectratypic analysis and nucleotide sequence, and 5) to analyze the interaction of NK1.1+ alpha/beta+ T cells with self-reactive T cells. ..
  48. IMMUNOBIOLOGY OF TYPE I DIABETES
    Kevin Lafferty; Fiscal Year: 1992
    ....
  49. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  50. BIOLOGICAL STUDIES OF THE BACTERIAL ARTHRITIS MODEL
    JOHN ZABRISKIE; Fiscal Year: 1990
    ..Hopefully further information gained from this animal model and a few selected studies in humans will shed light on the pathogenetic mechanisms involved in the human disease...
  51. CYTOMEGALOVIRUS AND MHC CLASS II IN TRANSPLANTATION
    Daniel Sedmak; Fiscal Year: 1999
    ....
  52. CLASS II FUNCTION IN INTESTINAL EPITHELIAL CELLS
    Robert Hershberg; Fiscal Year: 2003
    ..We anticipate that the experiments outlined in this grant proposal will highlight the IEC as an important therapeutic target in the modulation of mucosal immune and inflammatory responses. ..
  53. REGULATION OF HLA ANTIGEN EXPRESSION
    Peter Cresswell; Fiscal Year: 1991
    ..Identification and structural characterization of genes which mediate the pre- and post- translational control of HLA antigen expression may ultimately contribute to our understanding of the regulation of in vivo immune responses...
  54. CELLULAR & MOLECULAR CONTROL OF IA ANTIGEN EXPRESSION
    Jerold Woodward; Fiscal Year: 1991
    ..4) Evaluate the presence of sequence specific DNA binding proteins that may interact with the region involved in transcriptional blockage...
  55. IMMUNOLOGICAL MECHANISMS IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 1990
    ..Data generated will provide new insights into autoimmune thyroid disease at a fundamental level...
  56. INVARIANT CHAIN BASED VACCINE STRATEGIES
    Allan Hess; Fiscal Year: 2003
    ..These studies will identify novel strategies to enhance the immunogenicity of tumor peptides that may be broadly applicable to many different types of cancer. ..
  57. MODULATION OF REGULATORY TOLERANCE TO TRANSPLANTS
    Christian LeGuern; Fiscal Year: 2009
    ..It is hoped that these studies will provide the impetus for the design of new therapeutic molecules with clinical application in transplantation biology. ..
  58. The Regulatory Control Mechanisms of Cross-presentation by Toll-like Receptors
    JULIE MAGARIAN BLANDER; Fiscal Year: 2007
    ..The new knowledge we gain will further the design of therapeutic anti-viral and anti-tumor vaccines, and broaden our understanding of autoimmunity ..
  59. Doxorubicin-Immunoconjugate Therapy of Non-Hodgkin's Lymphoma
    Rhona Stein; Fiscal Year: 2008
    ..abstract_text> ..
  60. T Cell Recognition & Repertoire in Autoimmune Thyroditis
    YI CHI KONG; Fiscal Year: 2005
    ..4. Characterize the mechanisms of T cell regulation in mTg-induced resistance. ..
  61. MODULATION OF T LYMPHOCYTE REGULATION
    Christian LeGuern; Fiscal Year: 2009
    ..abstract_text> ..
  62. PRE-CLINICAL COMBINATION CHEMO- AND RADIOANTIBODY THERAP
    Rhona Stein; Fiscal Year: 2005
    ..2) Therapy-induced changes in marker expression post therapy can be identified clinically in small samples of circulating tumor cells. ..
  63. Immunoregulation in Cyclosporine-Induced Autoimmunity
    Allan Hess; Fiscal Year: 2003
    ..This unique model and the proposed studies will provide novel insights into systemic control of autoaggression. ..