Genomes and Genes
histocompatibility antigens class i
Summary: Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.
Publications316 found, 100 shown here
- NK cell recognitionLewis L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
Annu Rev Immunol 23:225-74. 2005..Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition...
- Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulationMichael R Betts
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
J Immunol Methods 281:65-78. 2003....
- How TCRs bind MHCs, peptides, and coreceptorsMarkus G Rudolph
Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
Annu Rev Immunol 24:419-66. 2006..Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs...
- FcRn: the neonatal Fc receptor comes of ageDerry C Roopenian
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Nat Rev Immunol 7:715-25. 2007..This Review summarizes these two areas of FcRn biology...
- Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptorRangsima Reantragoon
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Exp Med 209:761-74. 2012..This candidate docking mode contrasts with that of the NKT TCR-CD1d-antigen interaction, in which both the α and β chain of the NKT TCR is required for ligation above the F'-pocket of CD1d...
- The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cellsG B Cohen
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Immunity 10:661-71. 1999..These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV...
- MHC class I molecules and KIRs in human history, health and survivalPeter Parham
Departments of Structural Biology, and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Nat Rev Immunol 5:201-14. 2005..Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth...
- Functional requirement for class I MHC in CNS development and plasticityG S Huh
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Science 290:2155-9. 2000..These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS)...
- In search of the 'missing self': MHC molecules and NK cell recognitionH G Ljunggren
Department of Tumour Biology, Karolinska Institutet, Stockholm, Sweden
Immunol Today 11:237-44. 1990..The authors derive testable predictions for how MHC class I molecules act in cases where they control a rate-limiting step in the NK cell-target interaction...
- Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinomaVinod Kumar
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Nat Genet 43:455-8. 2011..13 × 10(-8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 × 10(-13))...
- A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosisJ N Feder
Mercator Genetics, Inc, Menlo Park, California 94025, USA
Nat Genet 13:399-408. 1996..A role of this gene in haemochromatosis is supported by the frequency and nature of the major mutation and prior studies implicating MHC class I-like proteins in iron metabolism...
- Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICAS Bauer
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Science 285:727-9. 1999..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
- Antimicrobial activity of mucosal-associated invariant T cellsLionel Le Bourhis
Departement de Biologie des Tumeurs, Institut Curie, Paris, France
Nat Immunol 11:701-8. 2010..In the mouse, MAIT cells protected against infection by Mycobacterium abscessus or Escherichia coli. Thus, MAIT cells are evolutionarily conserved innate-like lymphocytes that sense and help fight off microbial infection...
- Stepwise development of MAIT cells in mouse and humanEmmanuel Martin
Laboratoire d Immunologie, Institut Curie, Paris, France
PLoS Biol 7:e54. 2009..Thus, their development follows a unique pattern at the crossroad of NKT and gammadelta T cells...
- NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11Claus Lundegaard
CBS, Department of Systems Biology, Technical University of Denmark DTU, Kemitorvet Build 208, 2800 Lyngby, Denmark
Nucleic Acids Res 36:W509-12. 2008..Here, the performance is further validated and benchmarked using a large set of newly published affinity data, non-redundant to the training set. The server is free of use and available at: http://www.cbs.dtu.dk/services/NetMHC...
- A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolYihong Ye
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 429:841-7. 2004..Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor...
- Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysisA Moretta
Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
Annu Rev Immunol 19:197-223. 2001..Indeed, in patients with the X-linked lymphoproliferative disease, the inability to control Epstein-Barr virus infections may be consequent to a major dysfunction of 2B4 that exerts inhibitory instead of activating functions...
- Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activationVeronika Groh
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Nature 419:734-8. 2002..This mode of T-cell silencing may promote tumour immune evasion and, by inference, compromise host resistance to infections...
- Effect of NKG2D ligand expression on host immune responsesMarine Champsaur
Department of Microbiology and Immunology, The Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Immunol Rev 235:267-85. 2010..We also discuss the host response to both membrane-bound and secreted NKG2D ligands and summarize the models proposed to explain the consequences of this differential expression...
- Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cellsV Groh
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Science 279:1737-40. 1998..Thus, these molecules may broadly regulate protective responses by the Vdelta1 gammadelta T cells in the epithelium of the intestinal tract...
- Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICBV Groh
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 96:6879-84. 1999..These results raise the possibility that an induced expression of MICA/B, by conditions that may be related to tumor homeostasis and growth, could play a role in immune responses against tumors...
- Natural selection at major histocompatibility complex loci of vertebratesA L Hughes
Department of Biology, Pennsylvania State University, University Park 16802, USA
Annu Rev Genet 32:415-35. 1998..d) Introns have been homogenized relative to exons over evolutionary time, suggesting that balancing selection acts to maintain diversity in the latter, in contrast to the former...
- Mucosal-associated invariant T cells: unconventional development and functionLionel Le Bourhis
Institut Curie, Departement de Biologie des Tumeurs, Paris, 75005, France
Trends Immunol 32:212-8. 2011..MAIT cells secrete interferon-γ, and interleukin-17 under certain conditions. The species conservation, as well as the wide microbial reactivity, infer an important role for this cell population in immunity...
- Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infectionJoshua J Obar
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06030 1319, USA
Immunity 28:859-69. 2008..Thus, initial endogenous precursor frequencies were surprisingly diverse and not only regulated initial immune response characteristics but also controlled memory CD8+ T cell lineage decisions...
- MHC class I: an unexpected role in neuronal plasticityCarla J Shatz
Bio X and Departments of Biology and Neurobiology, James H Clark Center, 318 Campus Drive W1 1, Stanford University, Stanford CA 94305 5437, USA
Neuron 64:40-5. 2009....
- Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cellsV Groh
Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98109, USA
Nat Immunol 2:255-60. 2001..Combined triggering of TCR-CD3 complexes and NKG2D induced interleukin 2 production and T cell proliferation. Thus NKG2D functioned as a costimulatory receptor that can substitute for CD28...
- Mamu-B*08-positive macaques control simian immunodeficiency virus replicationJohn T Loffredo
Wisconsin National Primate Research Center, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
J Virol 81:8827-32. 2007..002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers...
- CD8(+) T cells: foot soldiers of the immune systemNu Zhang
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Immunity 35:161-8. 2011..Here we review recent advances in CD8(+) T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8(+) T cell expansion and differentiation are controlled in these contexts...
- Characterization of the expression of MHC proteins in human embryonic stem cellsMicha Drukker
Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, 91904 Jerusalem, Israel
Proc Natl Acad Sci U S A 99:9864-9. 2002..In conclusion, our results demonstrate that human ES cells can express high levels of MHC-I proteins and thus may be rejected on transplantation...
- Evasion of CD8+ T cells is critical for superinfection by cytomegalovirusScott G Hansen
Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
Science 328:102-6. 2010....
- MHC class I antigen presentation: learning from viral evasion strategiesTed H Hansen
Washington University School of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
Nat Rev Immunol 9:503-13. 2009....
- A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cellsS Rajagopalan
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
J Exp Med 189:1093-100. 1999..Therefore, given that HLA-G expression is restricted to fetal trophoblast cells, KIR2DL4 may provide important signals to maternal NK decidual cells that interact with trophoblast cells at the maternal-fetal interface during pregnancy...
- Natural killer cells and dendritic cells: rendezvous in abused tissuesAlessandro Moretta
Dipartimento di Medicina Sperimentale, Sezione di Istologia, and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, 16132 Genova, Italy
Nat Rev Immunol 2:957-64. 2002....
- Cytomegalovirus immune evasionC Powers
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97201, USA
Curr Top Microbiol Immunol 325:333-59. 2008..The multitude and complexity of these mechanisms is fascinating and continues to reveal novel insights into the host-pathogen interaction and novel cell biological and immunological concepts...
- Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesMark E Dudley
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA
Science 298:850-4. 2002..This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases...
- HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8⁺ T lymphocytesMarloes Gooden
Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Proc Natl Acad Sci U S A 108:10656-61. 2011....
- Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrationsMichela Traglia
Division of Genetics and Cell Biology, San Raffaele Research Institute, Milano, Italy
J Med Genet 48:629-34. 2011..Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin results in iron overload or iron deficiency and anaemia...
- KIR: diverse, rapidly evolving receptors of innate and adaptive immunityCarlos Vilches
Servicio de Inmunologia, Hospital Universitario Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
Annu Rev Immunol 20:217-51. 2002..This diversity likely contributes variability to the function of NK cells and T-lymphocytes by modulating innate and adaptive immune responses to specific challenges...
- Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processingLoredana Cifaldi
Oncohaematology Department, IRCCS, Ospedale Pediatrico Bambino Gesu, Rome, Italy
Cancer Res 71:1597-606. 2011..Because a large fraction of human tumors express high levels of the homologous ERAP1 and/or ERAP2, the present findings highlight a convenient, novel target for cancer immunotherapy...
- Modulation of HLA expression in human cytomegalovirus immune evasionAifen Lin
Medical Research Center, Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang 317000, China
Cell Mol Immunol 4:91-8. 2007....
- Licensing of natural killer cells by host major histocompatibility complex class I moleculesSungjin Kim
Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 436:709-13. 2005..This self-tolerance mechanism may be more broadly applicable within the vertebrate immune system because related germline-encoded inhibitory receptors are widely expressed on other immune cells...
- Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cellsJoel Lemaoult
Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique CEA DSV DRM, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
Blood 109:2040-8. 2007..These data re-emphasize the significance of HLA-G expression in normal and pathologic situations...
- Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challengeB S Bender
Department of Medicine, University of Florida College of Medicine, Gainesville
J Exp Med 175:1143-5. 1992..Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections...
- Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDSS Carl
Institute for Clinical and Molecular Virology, Friedrich-Alexander University, D-91054 Erlangen, Germany
J Virol 75:3657-65. 2001..These findings suggest that all in vitro Nef functions investigated contribute to AIDS pathogenesis and indicate that nef variants with increased pathogenicity emerge in a significant number of HIV-1-infected individuals...
- Regulation of cutaneous malignancy by gammadelta T cellsM Girardi
Department of Dermatology and Yale Skin Diseases Research Core Center, King s College, London SE1 9RT, UK
Science 294:605-9. 2001..Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy...
- Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1Emmanuel Treiner
Laboratoire d Immunologie and INSERM U520, Institut Curie, Paris 75005, France
Nature 422:164-9. 2003..This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B-cell activity...
- HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinomaLiz Y Han
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1155 Herman Pressler, CPB6 3244, Unit 1362, Houston, TX 77030, USA
Clin Cancer Res 14:3372-9. 2008..The purpose of this study is to determine the clinical significance of APM component down-regulation and tumor-infiltrating T cells in ovarian carcinoma...
- Unravelling natural killer cell function: triggering and inhibitory human NK receptorsLorenzo Moretta
Istituto Giannina Gaslini, Genova Quarto, Italy
EMBO J 23:255-9. 2004..Thus, the ability of NK cells to lyse target cells requires both the lack of surface MHC class I molecules and the expression of appropriate ligands that trigger NK receptors...
- HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cellsJoel Lemaoult
Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Département de Recherche Médicale Direction des Sciences du Vivant, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris 10, France
Proc Natl Acad Sci U S A 101:7064-9. 2004..Thus, HLA-G+ APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance...
- Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosisDeepani K Tennakoon
Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 176:7119-29. 2006..These studies not only explain several prior observations relating to the mechanism of this drug but also provide important insights into the natural immune interplay underlying this human immune-mediated disease...
- Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processingBritta Strehl
Institut fur Biochemie, Charite, Berlin University Berlin, Germany
Immunol Rev 207:19-30. 2005....
- Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in miceHéctor Pérez Montoyo
Department of Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9093, USA
Proc Natl Acad Sci U S A 106:2788-93. 2009..The primary sites for the maintenance of endogenous IgGs in mice are therefore endothelial and hematopoietic cells...
- Major histocompatibility complex genotyping with massively parallel pyrosequencingRoger W Wiseman
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin, USA
Nat Med 15:1322-6. 2009..The remarkable sensitivity of this approach in macaques demonstrates that pyrosequencing is viable for ultra-high-throughput MHC genotyping of primates, including humans...
- Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef proteinO Schwartz
Laboratoire Rétrovirus et Transfert Génétique, Unité de Recherche Associée CNRS 1157, Paris, France
Nat Med 2:338-42. 1996..The stimulation of MHC-I endocytosis by Nef represents a previously undocumented viral mechanism for evading the immune response...
- Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)Mitsunori Shiroishi
Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Proc Natl Acad Sci U S A 103:16412-7. 2006..These results suggest that subtle structural differences between LILRB family members cause the distinct binding specificities to various forms of HLA-G and other MHCIs, which may in turn regulate immune suppression...
- A novel immunoglobulin superfamily receptor for cellular and viral MHC class I moleculesD Cosman
Immunex Corporation, Seattle, Washington 98101, USA
Immunity 7:273-82. 1997..Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function...
- Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivoLianjun Shen
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Immunity 21:155-65. 2004..Therefore, cathepsin S plays a major role in generating presented peptides for the vacuolar pathway of crosspresentation, and this mechanism is active in vivo...
- Analysis of regulatory CD8 T cells in Qa-1-deficient miceDan Hu
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 5:516-23. 2004..These findings delineate a Qa-1-dependent T cell-T cell inhibitory interaction that prevents the pathogenic expansion of autoreactive CD4 T cell populations and consequent autoimmune disease...
- Proteasome and peptidase function in MHC-class-I-mediated antigen presentationPeter Michael Kloetzel
Institut fur Biochemie, Charité Medizinische Fakultät der Humboldt Universität zu Berlin, Monbijoustrasse 2, 10117 Berlin, Germany
Curr Opin Immunol 16:76-81. 2004..Recent evidence suggests that tripeptidyl peptidase II (TPPII), a large peptidase with exo-and endo-proteolytic activities, is also involved in antigen processing and may generate a specific set of MHC class I epitopes...
- A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeFleur E Tynan
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nat Immunol 8:268-76. 2007..Our findings represent a mechanism of antigen recognition whereby the plasticity of the T cell response is dictated mainly by adjustments in the MHC-bound peptide...
- An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptidesTomo Saric
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 3:1169-76. 2002..Like other proteins involved in antigen presentation, ERAP1 is induced by interferon-gamma. When overexpressed in vivo, we found that ERAP1 stimulates the processing and presentation of an antigenic precursor in the ER...
- Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-GMitsunori Shiroishi
Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Proc Natl Acad Sci U S A 100:8856-61. 2003....
- Imprint of human cytomegalovirus infection on the NK cell receptor repertoireMonica Guma
Molecular Immunopathology Unit, DCEXS, Universitat Pompeu Fabra, Barcelona, Spain
Blood 104:3664-71. 2004..Altogether, these data support that HCMV infection selectively shapes the natural killer cell receptor (NKR) repertoire of NK and T cells from healthy carrier individuals...
- A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopesManoj Bhasin
Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India
J Biosci 32:31-42. 2007..The method is available on the web at www.imtech.res.in/raghava/nhlapred and its mirror site is available at http://bioinformatics.uams.edu/mirror/nhlapred/...
- ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulumThomas Serwold
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
Nature 419:480-3. 2002..Thus, ERAAP is the missing link between the products of cytosolic processing and the final peptides presented by MHC class I molecules on the cell surface...
- Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent bindingW L Martin
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Mol Cell 7:867-77. 2001..The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives...
- Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gammaKirk D C Jensen
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Immunity 29:90-100. 2008..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens...
- The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand bindingJ N Feder
Progenitor, Inc formerly Mercator Genetics, Inc, 4040 Campbell Avenue, Menlo Park, CA 94025, USA
Proc Natl Acad Sci U S A 95:1472-7. 1998....
- Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I moleculesM Colonna
Basel Institute for Immunology, Switzerland
J Immunol 160:3096-100. 1998..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
- Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodiesR J Ober
Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8576, USA
Int Immunol 13:1551-9. 2001..Our results provide a molecular explanation for the enigmatic observation that mouse IgG behave anomalously in humans. These studies have implications for the successful application of therapeutic antibodies...
- Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cellsKristi Baker
Division of Gastroenterology, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:9927-32. 2011..Given the centrality of FcRn in controlling cross-presentation, these studies lay the foundation for a unique means to therapeutically manipulate CD8(+) T-cell responses...
- The transferrin receptor modulates Hfe-dependent regulation of hepcidin expressionPaul J Schmidt
Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
Cell Metab 7:205-14. 2008..Together, these models suggest that Hfe induces hepcidin expression when it is not in complex with Tfr1...
- HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetesHong Jiang
Department of Medicine, Naomi Berrie Diabetes Center NBDC, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 120:3641-50. 2010..These data suggest that HLA-E-restricted CD8(+) T cells may play an important role in keeping self-reactive T cells in check. Thus, correction of this defect could be a potentially effective and safe approach in the therapy of T1D...
- Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathwayLinrong Lu
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Immunity 26:593-604. 2007....
- Podocytes use FcRn to clear IgG from the glomerular basement membraneShreeram Akilesh
Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 105:967-72. 2008....
- Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primatesYik Andy Yeung
Department of Antibody Engineering, Genentech, South San Francisco, CA 94080, USA
J Immunol 182:7663-71. 2009..In contrast, N434A exhibited a approximately 2-fold decrease in clearance in cynomolgus monkey, supporting the notion that modest increases in pH 6 FcRn affinity can result in improved pharmacokinetics in primates...
- Herpes simplex virus infection downmodulates NKG2D ligand expressionD Schepis
Department of Microbiology, Tumor and Cell Biology and Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
Scand J Immunol 69:429-36. 2009..These data support a role for NKG2D-MICA interactions in immune responses to HSV-1 reactivation...
- Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathwaySilvia Gregori
Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
Blood 116:935-44. 2010..Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells...
- Soluble HLA-G inhibits cell cycle progression in human alloreactive T lymphocytesRajia Bahri
Institut National de la Santé et de la Recherche Médicale Unité 542, Villejuif, France
J Immunol 176:1331-9. 2006..In contrast, it induced an accumulation of p27kip, but not p21cip, in activated T cells. HLA-G does not induce apoptosis of alloreactive T cells, but induces p27kip1 and inhibits cell cycle progression...
- Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulumLoredana Saveanu
Institut National de la Sante et Recherche Médicale Unité 580, Universite Rene Descartes Paris 5, 75015 Paris, France
Nat Immunol 6:689-97. 2005..Thus, the human endoplasmic reticulum is equipped with a pair of trimming aminopeptidases that have complementary functions in HLA class I peptide presentation...
- HLA-G: from biology to clinical benefitsEdgardo D Carosella
Institut Universitaire d Hematologie, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 75010 Paris, France
Trends Immunol 29:125-32. 2008..These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels...
- A statistical method for predicting classical HLA alleles from SNP dataStephen Leslie
Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
Am J Hum Genet 82:48-56. 2008....
- ProPred1: prediction of promiscuous MHC Class-I binding sitesHarpreet Singh
Institute of Microbial Technology, Chandigarh 160036, India
Bioinformatics 19:1009-14. 2003..The simultaneous prediction of MHC binders and proteasome cleavage sites in an antigenic sequence leads to the identification of potential T-cell epitopes...
- Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: a CD4+ T cell regulatory mechanismN Lila
, , Direction des Sciences du Vivant, , , 1 avenue Claude-Vellefaux, 75010 Paris, France
Proc Natl Acad Sci U S A 98:12150-5. 2001..This inhibition may be reversed by adding the anti-HLA-G 87G antibody to a mixed lymphocyte culture. That may indicate a previously uncharacterized regulatory mechanism of CD4(+) T cell proliferative response...
- Antibodies against MICA antigens and kidney-transplant rejectionYizhou Zou
Transplantation Immunology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8886, USA
N Engl J Med 357:1293-300. 2007..We sought to determine whether an immune response to MICA antigens might play a role in the failure of kidney allografts...
- Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigensA Ishitani
Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092
Proc Natl Acad Sci U S A 89:3947-51. 1992..These findings are discussed in terms of potential functions of the alternative HLA-G proteins...
- Disulfide bond-mediated dimerization of HLA-G on the cell surfaceJonathan E Boyson
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 and Institute of Molecular Genetics, 142 20 Prague, Czech Republic
Proc Natl Acad Sci U S A 99:16180-5. 2002..The cell-surface expression of dimerized HLA-G molecules may have implications for HLA-Greceptor interactions and for the search for specific receptors that bind HLA-G...
- HLA-G and immune tolerance in pregnancyJoan S Hunt
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7400, USA
FASEB J 19:681-93. 2005....
- Host immune system gene targeting by a viral miRNANoam Stern-Ginossar
Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
Science 317:376-81. 2007..Our results reveal a miRNA-based immunoevasion mechanism that appears to be exploited by human cytomegalovirus...
- Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicityMair Thomas
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom
Proc Natl Acad Sci U S A 105:1656-61. 2008..The down-regulation of ligands for both the NKG2D and NKp80 activation pathways provides KSHV with a powerful mechanism for evasion of NK cell antiviral functions...
- SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ERBritta Mueller
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
J Cell Biol 175:261-70. 2006..These results allow us to place SEL1L in the broader context of glycoprotein degradation, and imply the existence of multiple independent modes of extraction of misfolded substrates from the mammalian ER...
- Tolerization of dendritic cells by HLA-GVladimir Ristich
Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta 30912 2600, USA
Eur J Immunol 35:1133-42. 2005..These findings provide support that HLA-G is an important tolerogenic molecule on DC for the acceptance of a semiallogeneic fetus and transplanted tissue/organ...
- Beyond the increasing complexity of the immunomodulatory HLA-G moleculeEdgardo D Carosella
CEA, IBM, Service de Recherches en Hemato Immunologie, Paris, France
Blood 111:4862-70. 2008..We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant...
- Hypoxia modulates HLA-G gene expression in tumor cellsGael Mouillot
Commissariat a l Energie Atomique, Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
Hum Immunol 68:277-85. 2007..Finally, we demonstrated for the first time that the modulation of HLA-G gene expression is dependent of HIF-1 stabilization and thus might be relevant for the control of HLA-G gene expression in hypoxic tumors...
- Structure of 20S proteasome from yeast at 2.4 A resolutionM Groll
Max Planck Institut fur Biochemie, Martinsreid, Germany
Nature 386:463-71. 1997....
- Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virusGabrielle T Belz
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Proc Natl Acad Sci U S A 101:8670-5. 2004..Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection...
- "Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapyFederico Garrido
Departamento de Bioquimica, Universidad de Granada, Granada, Spain
Int J Cancer 127:249-56. 2010..In this article, we discuss the importance of these two types of molecular mechanisms of MHC Class I-altered expression...
- Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142N Jan Chalupny
Amgen, 1201 Amgen Court West, Seattle, WA 98119 3105, USA
Biochem Biophys Res Commun 346:175-81. 2006....
- Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cellsMalin Hedlund
Division of Clinical Immunology, Department of Clinical Microbiology, Umea University, Umea, Sweden
PLoS ONE 6:e16899. 2011..The adverse effect of thermal and oxidative stress, enhancing the release of immunosuppressive exosomes, should be considered when cytostatic and hyperthermal anti-cancer therapies are designed...
- High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosisMaria Benevolo
Department of Pathology, Regina Elena National Cancer Institute, Via E Chianesi 53, 00144 Rome, Italy
J Transl Med 9:184. 2011..In view of the opposing outcomes (activation or inhibition) of the different HLA-E receptors, the preferred role (if any) of HLA-E expressed in vivo on tumor cells remains to be established...
- Neonatal Fc receptor: from immunity to therapeuticsTimothy T Kuo
Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Clin Immunol 30:777-89. 2010..Here, we aim to summarize the basic understanding of FcRn biology, its functions in various organs, and the therapeutic design of antibody- and albumin-based therapeutics in light of their interactions with FcRn...
- CELLULAR ORIGINS OF RAT HEPATIC PRENEOPLASIASPhilip Iannaccone; Fiscal Year: 1991....
- SIGNALLING THROUGH A T CELL KINASE, P56 LCKAndrey Shaw; Fiscal Year: 1992..Aberrant signalling through CD4 could play a role in HIV pathogenesis. ..
- IMMUNOLOGICAL ENHANCEMENT OF RENAL ALLOGRAFTSFRANK STUART; Fiscal Year: 1980..We will also combine various effective supernatants in an attempt to achieve enhancement without the need for concomitant donor strain spleen cells. ..
- DECIDUAL CELL/PLACENTAL INTERACTIONSJOAN HUNT; Fiscal Year: 2007..abstract_text> ..
- A Mouse Model of Gaucher DiseaseErnest Beutler; Fiscal Year: 2005..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
- Iron Status: A Pathway Analysis in Multiple EthnicitiesChristine McLaren; Fiscal Year: 2009..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
- Interactions and mechanisms of function of the TAP ComplexMalini Raghavan; Fiscal Year: 2008..abstract_text> ..
- Mycobacterium tuberculosis-reactive thymocytesMARIELLE GOLD; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Calreticulin's functions in the adaptive immune responseMalini Raghavan; Fiscal Year: 2010..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
- Conference of the Society for Natural ImmunityWayne Yokoyama; Fiscal Year: 2005..abstract_text> ..
- Ocular Regulation of AutoimmunityROBERT CONE; Fiscal Year: 2009..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
- DNA Methylation as an Epigenetic Host Factor in HIV/AIDSJianming Tang; Fiscal Year: 2006..abstract_text> ..
- Conference on Innate Immunity to PathogensWayne Yokoyama; Fiscal Year: 2005..abstract_text> ..
- MOLECULAR MODEL FOR T-CELL RECEPTOR LIGAND INTERACTIONSNilabh Shastri; Fiscal Year: 2007..We expect the findings to reveal new insights into the nature of endogenous peptides presented by MHC class II and MHC class I molecules in normal cells as well as fundamental issues in transplantation immunology. ..
- VIRAL EVASION STRATEGIES: ANALYSIS OF HERPES VIRUSES HSV, VZV AND HHV-6-7Hidde Ploegh; Fiscal Year: 2007..This analysis should reveal if and to what extent the MHC alleles in the human population help shape the "repertoire" of immunoevasins. ..
- Functional Proteomics of HIV-1-Specific CD8+ T cellsXu Yu; Fiscal Year: 2007..Overall, our investigations will be relevant for defining key signaling networks of HI V-1-specific CD8+ T cells associated with protective immunity against HIV-1. [unreadable] [unreadable]..
- CD8+ T Cells Control Autoimmunity In EAEHong Jiang; Fiscal Year: 2007..Thus, the studies will provide theoretical basis for clinical application of this regulatory pathway in prevention and treatment of multiple sclerosis in man. [unreadable] [unreadable] [unreadable]..
- Antigen processing in the secretory pathwayNilabh Shastri; Fiscal Year: 2010..abstract_text> ..
- ROLE OF NON-CLASSICAL MHC CLASS I AND HSPs IN IMMUNITYJacques Robert; Fiscal Year: 2009..Do hsp70 and gp96 generate similar anti-tumor CCU-CTL effectors? Aim 3. How important is the hsp-generated CCU-CTL responses in tumor immunity in vivo? Aim 4. Do CCU-CTLs interact with class Ib molecules? ..
- Thymic Influence on Ocular ImmunoregulationRobert E Cone; Fiscal Year: 2010....
- The genetic basis of type 1 diabetes autoimmunity in African AmericansJanelle Noble; Fiscal Year: 2008..abstract_text> ..
- Genetic Epidemiology of Adult Brain Cancer: A Follow-up StudyJianming Tang; Fiscal Year: 2008..abstract_text> ..
- Regulation of the baboon HLA-G-like class Ib MHC gene, Paan-AGDAUDI LANGAT; Fiscal Year: 2008..Thus the baboon is clearly an excellent model for HLA-G functional experiments, and testing the therapeutic applications of HLA-G in human pregnancy and transplantation. [unreadable] [unreadable] [unreadable] [unreadable]..
- GENERATING ANTIGENIC PEPTIDE/MHC BY CRYPTIC TRANSLATIONNilabh Shastri; Fiscal Year: 2010....
- Brain Development on Adults with SchizophreniaGeorge Bartzokis; Fiscal Year: 2008..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
- ASSEMBLY AND TRAFFICKING OF MHC CLASS II MOLECULESHidde Ploegh; Fiscal Year: 2008..H2 H4 mouse (autoimmune thyroiditis). We have backcrossed the CatB, CatL and CatS -/- mutations onto the NOD background and will explore the consequences of these cathepsin deficiencies for onset and severity of disease. ..
- Modulation of type I diabetes with NKT cellsLuc Van Kaer; Fiscal Year: 2006..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
- EXPRESSION, SPECIFICITY, AND FUNCTION OF LY49 FAMILYWayne Yokoyama; Fiscal Year: 2001..Thus, these studies will provide fundamental new information that will further elucidate the function of NK cells and their tolerance mechanisms. ..
- NOTCH SIGNALING IN THYMOCYTE DEVELOPMENTMichael Bevan; Fiscal Year: 2003..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
- CD8+ T CELL RECOGNITION OF TH1 AND TH2Hong Jiang; Fiscal Year: 2003..We will determine if this difference uniquely applies to the recognition of TCR peptide presented by Qa-1 or if CD8+ T cells specific for other peptides presented by MHC class I molecules also distinguish between TH1 and TH2 targets. ..
- CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATIONROBERT CONE; Fiscal Year: 2003..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
- PHD PROGRAM IN IMMUNOLOGYHidde Ploegh; Fiscal Year: 2004..The experimental component usually requires 3-4 years to complete a body of work considered adequate for a written thesis. ..
- Linking Innate with Adaptive Immune ResponseWayne Yokoyama; Fiscal Year: 2003..This meeting will be especially rewarding for students and postdoctoral fellows in search of opportunities for future research and challenges. ..
- CELL BIOLOGY OF HEAT SHOCK PROTEIN MEDIATED IMMUNIZATIONHidde Ploegh; Fiscal Year: 2002....
- HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTIONHidde Ploegh; Fiscal Year: 2003....
- BIOLOGY OF HUMAN UTERINE NK CELLSAshley Moffett; Fiscal Year: 2004..It could lead to novel therapeutic approaches in a wide range of disorders including infertility, miscarriage, disorders due to defective placentation (pre-eclampsia and IUGR) and menstrual disorders. ..
- Modulation of EAE with ligand-activated NKT cellsLuc Van Kaer; Fiscal Year: 2005..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
- ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVOHidde Ploegh; Fiscal Year: 2007..abstract_text> ..
- Immune Correlates of Protection in Drug-Resistant HIVBrinda Emu; Fiscal Year: 2008..For Aims 1 and 2, I will use samples collected in an established cohort study. For Aim 3, I will conduct a prospective interventional study, where I will design and implement an independent clinical research project. ..
- Bioinformatic Mapping of HIV-1 Nef Manipulation of T-Cell Activation and FunctionJason Barbour; Fiscal Year: 2008..Variation in circulating strains of HIV-1 may account for this variation. We intend to map viral genetic determinants of T cell activation within the HIV-1 Nef protein. [unreadable] [unreadable] [unreadable]..
- Signaling Pathways in Hepatic FibrogenesisBruce Bacon; Fiscal Year: 2005..Since activated HSC play a key role in hepatic fibrogenesis, these experiments will contribute to an improved understanding of the basic biochemical processes underlying hepatic fibrosis. ..
- Pulmonary Hypertension and the Hypoxic Response in SCDVictor Gordeuk; Fiscal Year: 2008..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
- Epidemiology and Incidence of Barrett's EsophagusDOUGLAS ALLEN CORLEY; Fiscal Year: 2010..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
- FORMATION AND SURVIVAL OF RED BLOOD CELLSErnest Beutler; Fiscal Year: 2001..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
- MODULATION OF REGULATORY TOLERANCE TO TRANSPLANTSChristian LeGuern; Fiscal Year: 2009..It is hoped that these studies will provide the impetus for the design of new therapeutic molecules with clinical application in transplantation biology. ..
- Cannabinoid Receptor Dynamics in T Cell ActivationNICHOLAS GASCOIGNE; Fiscal Year: 2002..We will express fluorescent CB2 in APC, to see how expression is affected by drug exposure and by interaction with T cells. ..
- Identification of auto antigens in ovarian cancerRamila Philip; Fiscal Year: 2006..abstract_text> ..
- MODULATION OF T LYMPHOCYTE REGULATIONChristian LeGuern; Fiscal Year: 2009..abstract_text> ..
- Copper's Role in Brain LRP-mediated Abeta Efflux and AgingRashid Deane; Fiscal Year: 2010..These studies may provide new therapeutic insights on how to lower brain A[unreadable] by controlling its CNS barriers transport in Cu-potentiated neurodegenerative disorders. ..
- Sex-based Differences in the Immune ResponseBetty Diamond; Fiscal Year: 2005..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
- An antigen induced model of SLEBetty Diamond; Fiscal Year: 2005..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
- Exploiting porcine cytomegalovirus stealth mechanismsMARK CREW; Fiscal Year: 2005..The Phase I project will be deemed successful when we have identified specific genes from PCMV which impart stealth to pig cells in vitro when exposed to cells from the human immune system. ..
- SOLUBLE T CELL RECEPTOR STUDIES ON MHC RESTRICTIONNICHOLAS GASCOIGNE; Fiscal Year: 2006..TCR dimerization will be investigated in solution, using biophysical methods including FRET, analytical ultracentrifugation and BIAcore. ..
- Isolation and Characterization of a Ferritin ReceptorJames Connor; Fiscal Year: 2005..This project will significantly alter our thinking on brain iron transport and open novel directions for research in oligodendrocyte biology and diagnositic and therapeutic strategies in demyelinating disorders ..
- Immune Parameters in a Steroid Sparing Clinical TrialNancy Reinsmoen; Fiscal Year: 2005..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..
- A Rapid Method for HLA-typing by HaplotypingJohannes Dapprich; Fiscal Year: 2006..It is a further goal of Phase II to demonstrate the direct compatibility of HSE with existing SNP-mapping information and to expand the automation of HSE to a 96-well platform. ..
- Ethanol Effects on Antigen Presentation in Liver CellsNatalia Osna; Fiscal Year: 2006..unreadable] [unreadable]..
- EIAV Control by High Avidity Rev-Specific CTL ClonesROBERT MEALEY; Fiscal Year: 2005..The information obtained from the proposed studies should have implications for HIV-1 immunotherapy and vaccine design, where experiments of this type may be more difficult. ..
- FASEB Research Conference on: AutoimmunityBetty Diamond; Fiscal Year: 2004..Many investigators consider it to be the premier meeting on autoimmunity. ..
- Iron as a Nutritional Modifier of Toxic Neuropathy in HIV/AIDSAsha Kallianpur; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTIONVictor Gordeuk; Fiscal Year: 2004..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
- Peptides/MHC-I complexes and CD8+T cellsHerman Eisen; Fiscal Year: 2004..The overall goal is to help provide a platform to aid in the development of immunization strategies leading to increased yields of potent memory CD8 T cells. ..
- ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)Paul Goepfert; Fiscal Year: 2006..Recently, the Alabama clinic enrolled 125 higher-risk gay men in <5 months in the first US phase III trial. Plans for utilizing these cohorts and others are described. ..
- Regulatory T cells in transplantation toleranceJames Markmann; Fiscal Year: 2008..Collectively, these studies will further our understanding of regulatory T cell function in vivo and help to define their potential for application in the clinical transplant arena. ..
- MECHANISMS FOR FORMATION OF CELL MEMBRANE DOMAINSMichael Edidin; Fiscal Year: 2002..The PI proposes to test his model using cells in which the barriers to lateral mobility are defective, sph/sph, alpha-spectrin-deficient, erythroleukemia cells, and cells in which vesicle traffic from and to the surface is inhibited. ..
- Antibody Immunotherapy to a Pro-apoptotic Tumor AntigenKenneth Rock; Fiscal Year: 2004..In another set of experiments, we will test the effect of p40 on human tumors transplanted into immunodeficient mice. ..
- CTL-BASED VACCINES FOR THE AIDS VIRUSDavid Watkins; Fiscal Year: 2003..John Altman will synthesize MHC class I tetramers for CTL quantitation and Deborah Fuller will immunize animals using the gene gun. ..
- MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERSGregory Petsko; Fiscal Year: 2006..abstract_text> ..