neuronal cell adhesion molecules

Summary

Summary: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.

Top Publications

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
  2. ncbi Reelin, lipoprotein receptors and synaptic plasticity
    Joachim Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texus 75390, USA
    Nat Rev Neurosci 7:850-9. 2006
  3. ncbi Reelin and brain development
    Fadel Tissir
    Developmental Genetics Unit, Universite Catholique de Louvain, UCL 7382, 73 Avenue E Mounier, B1200 Brussels, Belgium
    Nat Rev Neurosci 4:496-505. 2003
  4. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
  5. ncbi Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules
    Thomas Biederer
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Genomics 87:139-50. 2006
  6. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
  7. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
  8. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
  9. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
  10. ncbi Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    Uwe Beffert
    Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 277:49958-64. 2002

Research Grants

  1. CARBOHYDRATE RECOGINTION IN NEURONAL PATTERN FORMATION
    Birgit Zipser; Fiscal Year: 2002
  2. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
  3. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  4. L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETON
    Michael Hortsch; Fiscal Year: 2002
  5. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
  6. Reelin and GAD67 Downregulation
    Erminio Costa; Fiscal Year: 2005
  7. GABAergic molecular pathology in schizophrenia
    Erminio Costa; Fiscal Year: 2008
  8. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
  9. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
  10. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009

Detail Information

Publications261 found, 100 shown here

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    ..The encoded protein resembles extracellular matrix proteins involved in cell adhesion. The reeler phenotype thus seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin...
  2. ncbi Reelin, lipoprotein receptors and synaptic plasticity
    Joachim Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texus 75390, USA
    Nat Rev Neurosci 7:850-9. 2006
    ..Here, we review the molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival...
  3. ncbi Reelin and brain development
    Fadel Tissir
    Developmental Genetics Unit, Universite Catholique de Louvain, UCL 7382, 73 Avenue E Mounier, B1200 Brussels, Belgium
    Nat Rev Neurosci 4:496-505. 2003
  4. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
    ....
  5. ncbi Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules
    Thomas Biederer
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Genomics 87:139-50. 2006
    ..These findings aim to facilitate the understanding of SynCAM genes and provide the framework to examine the physiological functions of this family of vertebrate-specific adhesion molecules...
  6. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons...
  7. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
    ..Taken together, these findings suggest that Reelin acts via VLDLR and ApoER2 to regulate Disabled-1 tyrosine phosphorylation and microtubule function in neurons...
  8. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
    ..The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and mDab1 function as signalling molecules that regulate cell positioning in the developing brain...
  9. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
    ..These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1...
  10. ncbi Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    Uwe Beffert
    Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 277:49958-64. 2002
    ....
  11. ncbi Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 47:567-79. 2005
    ..Thus, alternative splicing of Apoer2, a novel component of the NMDA receptor complex, controls the modulation of NMDA receptor activity, synaptic neurotransmission, and memory by Reelin...
  12. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
    ..In dissociated neurons, apoE reduces the level of Reelin-induced tyrosine phosphorylation of Dab1. These data suggest that Reelin directs neuronal migration by binding to VLDLR and ApoER2...
  13. ncbi Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin
    M A Bhat
    Cardiovascular Research Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 30:369-83. 2001
    ..These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction...
  14. pmc Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development
    T Sakurai
    W M Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    J Cell Biol 154:1259-73. 2001
    ..The combined results indicate that Nr-CAM and L1 play a role in cerebellar granule cell development, and suggest that closely related molecules in the L1 family have overlapping functions...
  15. ncbi The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development
    Yves Jossin
    Developmental Genetics Unit, University of Louvain Medical School, B1200 Brussels, Belgium
    J Neurosci 24:514-21. 2004
    ..They also indicate that events acting in parallel to Dab1 phosphorylation might be required for full activity...
  16. ncbi Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr
    E J Arroyo
    Department of Neurology, The University of Pennsylvania Medical Center, Pennsylvania, USA
    J Neurocytol 28:333-47. 1999
    ..1 genes. At all of these locations, Caspr and Kv1.1/Kv1.2/Kvbeta2 define distinct but interrelated domains of the axonal membrane that appear to be organized by the myelin sheath...
  17. ncbi The immunoglobulin superfamily of neuronal cell adhesion molecules: lessons from animal models and correlation with human disease
    Markella Katidou
    University of Crete, Faculty of Medicine, Vassilika Vouton, Heraklion, Crete, Greece
    Biotechnol J 3:1564-80. 2008
    b>Neuronal cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) play a crucial role in the formation of neural circuits at different levels: cell migration, axonal and dendritic targeting as well as synapse formation...
  18. pmc Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions
    E Peles
    SUGEN, Inc, Redwood City, CA 94063, USA
    EMBO J 16:978-88. 1997
    ..The binding of RPTPbeta to the contactin-Caspr complex could provide a mechanism for cell-cell communication between glial cells and neurons during development...
  19. ncbi Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway
    Sanyong Niu
    The Cain Foundation Laboratories, Houston, TX 77030, USA
    Neuron 41:71-84. 2004
    ..Thus, the same signaling pathway controls both neuronal migration and dendrite maturation...
  20. ncbi Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development...
  21. pmc The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning
    Ruth I Johnson
    Department of Developmental and Regenerative Biology, Mount Sinai Medical School, New York, NY 10029, USA
    J Cell Biol 180:1191-204. 2008
    ..Together, these data demonstrate that Cindr is involved in dynamic cell rearrangement in an emerging epithelium...
  22. ncbi SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
    ....
  23. ncbi Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve
    M E Boyle
    Neurobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
    Neuron 30:385-97. 2001
    ..1 and Kv1.2 potassium channels. Thus, contactin is a crucial part in the machinery that controls junctional attachment at the paranode and ultimately the physiology of myelinated nerve...
  24. ncbi Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick
    F E Perrin
    Pharmacenter, University of Basel, CH 4056, Basel, Switzerland
    Neuron 30:707-23. 2001
    ..Whereas nociceptive pathfinding depends on NgCAM and axonin-1, proprioceptive fibers require NrCAM and F11...
  25. ncbi Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosci 17:23-31. 1997
    ..The reelin gene product seems to function as an instructive signal in the regulation of neuronal migration...
  26. ncbi Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus
    Eckart Forster
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Eur J Neurosci 23:901-9. 2006
    ..Then, we review critically some cell biological mechanisms for the action of Reelin based on recent studies on the development of the dentate gyrus, which has proved an extremely useful and tractable model system...
  27. ncbi Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule
    G Grenningloh
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 67:45-57. 1991
    ..Thus, fasciclin II functions as a neuronal recognition molecule for the MP1 axon pathway. These studies serve as molecular confirmation for the existence of functional labels on specific axon pathways in the developing nervous system...
  28. pmc Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 157:1247-56. 2002
    ..These results suggest that Caspr serves as a "transmembrane scaffold" that stabilizes the Caspr/contactin adhesion complex at the paranodal junction by connecting it to cytoskeletal components within the axon...
  29. ncbi Selective capability of SynCAM and neuroligin for functional synapse assembly
    Yildirim Sara
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:260-70. 2005
    ..Are these molecules isofunctional, or do all neuronal cell adhesion molecules nonspecifically activate synapse formation? To address these questions, we analyzed the properties of ..
  30. ncbi Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1
    Yan Liu
    Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 25:10556-63. 2005
    ....
  31. pmc Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination
    Patrice Maurel
    Department of Cell Biology and Neurology, Smilow Neuroscience Program, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 178:861-74. 2007
    ..These results demonstrate a key role for Necl-4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode...
  32. ncbi Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Biol 10:877-85. 2000
    ..Complete loss of Dab1, however, recapitulates the Reln phenotype...
  33. ncbi Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
    C M Schuster
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 17:641-54. 1996
    ..Fas II can also control synaptic growth; various FasII alleles lead to either an increase or decrease in sprouting, depending upon the level of Fas II...
  34. ncbi Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity
    Pim C Lunter
    Department of Biochemistry 161, Nijmegen Center of Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Cancer Res 65:8801-8. 2005
    ..These data attribute a novel signaling role to ALCAM in regulation of proteolysis and support its previously postulated sensor function in invasive growth...
  35. ncbi Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
    Hans H Bock
    Department of Molecular Genetics and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390 9046, USA
    J Biol Chem 278:38772-9. 2003
    ..Using a neuronal migration assay, we also show that PI3K signaling is required for the formation of a normal cortical plate, a step that is dependent upon Reelin signaling...
  36. ncbi Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability
    E Costa
    Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Neurobiol Dis 8:723-42. 2001
    ..This hypothesis is supported by a genetic mouse model of reelin haploinsufficiency that replicates the above-described dendritic and presynaptic GABAergic defects documented in schizophrenia brains...
  37. ncbi A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function
    S Baumgartner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 87:1059-68. 1996
    ..These studies identify NRX as the first transmembrane protein of SJ and demonstrate a requirement for NRX in the formation of septate-junction septa and intercellular barriers...
  38. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
    ....
  39. ncbi Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 26:3319-29. 2006
    ..Together, our data suggest that the molecular machinery underlying axonal insulation and axon-glial interactions may be conserved across species...
  40. pmc Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn
    L Zeng
    Institute for Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Cell Biol 147:707-14. 1999
    ....
  41. ncbi Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
    A Guidotti
    Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Room 256, Chicago, IL 60612, USA
    Arch Gen Psychiatry 57:1061-9. 2000
    ....
  42. ncbi Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP
    Orlando D Gil
    Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    J Neurobiol 51:190-204. 2002
    ....
  43. ncbi The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity
    A J Furley
    Department of Biochemistry and Molecular Biophysics, New York, New York
    Cell 61:157-70. 1990
    ....
  44. ncbi Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains
    Ivo Spiegel
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Neurosci 20:283-97. 2002
    ..The structural organization and distinct cellular distribution of Caspr3 and Caspr4 suggest a potential role of these proteins in cell recognition within the nervous system...
  45. ncbi Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules
    Dyke P McEwen
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 279:52744-52. 2004
    ..2 cell surface density over alpha alone, similar to that shown previously for contactin and beta2. We propose that beta1 is the critical communication link between sodium channels, nodal cell adhesion molecules, and ankyrinG...
  46. ncbi cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP)
    A F Pimenta
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway 08854, USA
    Gene 170:189-95. 1996
    ..With a unique distribution in limbic structures, LAMP may play an important role in limbic system development and function, as suggested by previous in vitro and in vivo functional studies...
  47. pmc Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 USA
    Genes Dev 13:643-8. 1999
    ..In primary neuronal cultures, Dab1 tyrosine phosphorylation is stimulated by exogenous Reln. These results suggest that Reln regulates neuronal positioning by stimulating Dab1 tyrosine phosphorylation...
  48. pmc Caspr regulates the processing of contactin and inhibits its binding to neurofascin
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100 Israel
    J Cell Biol 163:1213-8. 2003
    ..These results demonstrate that Caspr regulates the intracellular processing and transport of contactin to the cell surface, thereby affecting its ability to interact with other cell adhesion molecules...
  49. ncbi The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons
    M Ogawa
    Department of Physiology, Kochi Medical School, Japan
    Neuron 14:899-912. 1995
    ..These findings revealed that the selective expression of a distinct molecule on Cajal-Retzius neurons is critical for the normal lamination of cortical neurons in the mammalian neocortex...
  50. ncbi Secreted Reelin molecules form homodimers
    Ken ichiro Kubo
    Department of Molecular Neurobiology, Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Neurosci Res 43:381-8. 2002
    ..Proper but not simple extracellular crosslinking of the receptors by these dimers may be important for Reelin signaling to occur...
  51. ncbi The reeler mouse as a model of brain development
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, Belgium
    Adv Anat Embryol Cell Biol 150:1-106. 1998
  52. ncbi The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves
    Tadahide Furuno
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Immunol 174:6934-42. 2005
    ..At points of contact between neurites and wild-type BMMC, SgIGSF/SynCAM was locally concentrated in both neurites and BMMC. SgIGSF/SynCAM on mast cells appeared to predominantly mediate attachment and promote communication with nerves...
  53. ncbi The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
    Qin Shen
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Nat Neurosci 9:743-51. 2006
    ..Our data demonstrate that neural stem cells change neuropotency during development and have a window of plasticity when restrictions can be reversed...
  54. ncbi Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex
    D Graus-Porta
    Friedrich Miescher Institute, Maulbeerstr 66, 4058, Basel, Switzerland
    Neuron 31:367-79. 2001
    ..The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases...
  55. ncbi Tbr1 regulates differentiation of the preplate and layer 6
    R F Hevner
    Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 29:353-66. 2001
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
  56. pmc Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers
    Maria Traka
    Department of Basic Science, University of Crete Medical School, Heraklion 71110, Crete, Greece
    J Cell Biol 162:1161-72. 2003
    ..This complex is analogous to that described previously at paranodes, suggesting that similar molecules are crucial for different types of axo-glial interactions...
  57. ncbi Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination
    J C Rios
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 20:8354-64. 2000
    ..These results strongly suggest that a preformed complex of Caspr and contactin is targeted to the paranodal junctions via extracellular interactions with myelinating glia...
  58. ncbi The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin
    E Peles
    SUGEN, Incorporated, Redwood City, California 94063 4720, USA
    Cell 82:251-60. 1995
    ..The interaction between contactin and RPTP beta may generate unidirectional or bidirectional signals during neural development...
  59. ncbi Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1
    David Benhayon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Brain Res Mol Brain Res 112:33-45. 2003
    ..These findings demonstrate that ApoER2 and VLDLR are essential for Reelin signaling and that no other receptor molecules can compensate for their role in mediating tyrosine phosphorylation of Dab1...
  60. ncbi Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
    M N Rasband
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 19:7516-28. 1999
    ..In Shiverer, ankyrin-3/G labeling was abnormal, suggesting that its localization also depends on axoglial contact...
  61. ncbi Contactin associates with Na+ channels and increases their functional expression
    K Kazarinova-Noyes
    Departments of Neurobiology Anatomy and Biochemistry Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 21:7517-25. 2001
    ..Contactin may thus significantly influence the functional expression and distribution of Na(+) channels in neurons...
  62. ncbi Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    Markus Missler
    Center for Basic Neuroscience, Department of Molecular Genetics, Dallas, Texas 75390 9111, USA
    Nature 423:939-48. 2003
    ..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery...
  63. pmc Common genetic variants on 5p14.1 associate with autism spectrum disorders
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Nature 459:528-33. 2009
    ..Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs...
  64. ncbi Changing patterns of gene expression define four stages of cerebellar granule neuron differentiation
    S G Kuhar
    Department of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021 6399
    Development 117:97-104. 1993
    ..The developmentally transient and spatially restricted expression of clones GC9 and GC44 identify a previously unrecognized step in cerebellar histogenesis...
  65. ncbi Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily
    Y Yoshihara
    Department of Neuroscience, Osaka Bioscience Institute, Japan
    J Neurobiol 28:51-69. 1995
    ..These results suggest that BIG-2, BIG-1, TAG-1, and F3 may play important roles in the formation and maintenance of specific neuronal networks in the brain...
  66. ncbi Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
    Edwin J Weeber
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:39944-52. 2002
    ..Thus, the impairment of apoE receptor-dependent neuromodulation may contribute to cognitive impairment and synaptic loss in Alzheimer disease...
  67. pmc Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer
    Bhaumik B Patel
    Veterans Administration Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Biochem Biophys Res Commun 378:344-7. 2009
    ..Moreover, our observation of the age-related rise in CSC in macroscopically normal colonic mucosa suggests a predisposition of the organ to developing colorectal cancer...
  68. ncbi Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, 61 rue de Bruxelles, B 5000 Namur, Belgium
    Exp Neurol 156:214-7. 1999
    ..This enzyme and the physiological meaning of reelin processing remain to be characterized further...
  69. ncbi Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cell Mol Neurobiol 22:139-52. 2002
    ..5. These results suggest that Reelin 410 deficiency may be a vulnerability factor in the pathology of autism...
  70. ncbi Identification and characterization of the human cell adhesion molecule contactin
    R A Reid
    Becton Dickinson and Company Research Center, Research Triangle Park, NC 27709
    Brain Res Mol Brain Res 21:1-8. 1994
    ..Highly expressed multiple transcripts, similar in pattern to that of pancreas, lung, kidney and skeletal muscle, are also observed in human neuroblastoma and retinoblastoma cell lines...
  71. ncbi Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients
    Delia Mezzanzanica
    Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 14:1726-33. 2008
    ..In a retrospective study, we investigated the prognostic impact of activated leukocyte cell adhesion molecule (ALCAM) expression in epithelial ovarian cancer...
  72. ncbi L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns
    E Fransen
    Department of Medical Genetics, University of Antwerp, B 2610 Antwerp, Belgium
    Hum Mol Genet 7:999-1009. 1998
    ..Additionally, the cerebellar vermis of the KO mice is hypoplastic. Their exploratory behavior is characterized by stereotype peripheral circling reminiscent of that of rodents with induced cerebellar lesions...
  73. pmc Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis
    Stephanie L Barrow
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Neural Dev 4:17. 2009
    ..Here, we investigate how a single type of cell adhesion molecule can recruit multiple types of synaptic proteins to new synapses with distinct mechanisms and time courses...
  74. ncbi Disease-associated mutations in L1 CAM interfere with ligand interactions and cell-surface expression
    Elena De Angelis
    Cambridge Institute for Medical Research and Cambridge University Department of Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Hum Mol Genet 11:1-12. 2002
    ....
  75. pmc Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules
    P Milev
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 127:1703-15. 1994
    ....
  76. ncbi Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder
    A M Persico
    Laboratory of Neuroscience, Department of Physiology and Neuroscience, Libera Università Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
    Mol Psychiatry 6:150-9. 2001
    ..Triplet repeats located in 5' untranslated regions (5'UTRs) are indicative of strong transcriptional regulation. Our findings suggest that longer triplet repeats in the 5'UTR of the RELN gene confer vulnerability to autistic disorder...
  77. ncbi Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression
    E O Berglund
    The Burnham Institute Neurobiology Program, La Jolla, California 92037, USA
    Neuron 24:739-50. 1999
    ..These results demonstrate that contactin controls axonal and dendritic interactions of cerebellar interneurons and contributes to cerebellar microorganization...
  78. ncbi The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance
    Frederic Charron
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 113:11-23. 2003
    ..These results provide evidence that Shh, acting via Smo, is a midline-derived chemoattractant for commissural axons and show that a morphogen can also act as an axonal chemoattractant...
  79. ncbi Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer
    David Horst
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Germany
    Cancer Invest 27:844-50. 2009
    ..We show that CD133 is the best sole marker to predict low patient survival, while the combined analysis of all three markers may be superior in identification of low-, intermediate-, and high-risk cases of colorectal cancer...
  80. pmc A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons
    D Fitzli
    Institute of Biochemistry, University of Zurich, Switzerland
    J Cell Biol 149:951-68. 2000
    ..Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth...
  81. ncbi Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons
    T Schneider
    Institut fur Biologie III, Albert Ludwigs Universitat Freiburg, Germany
    Neuron 15:259-71. 1995
    ..Epigenesis of the phenotypes can be explained partially on the bases of homophilic irreC-rst interactions...
  82. ncbi Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis
    Guus Wolswijk
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105AZ Amsterdam, The Netherlands
    Brain 126:1638-49. 2003
    ..This may impair saltatory impulse conduction and lead to further myelin loss, thereby contributing to disease progression in multiple sclerosis...
  83. pmc A decrease of reelin expression as a putative vulnerability factor in schizophrenia
    F Impagnatiello
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 95:15718-23. 1998
    ..We also observed a large (up to 70%) decrease of GAD67 but only a small decrease of GAD65 protein content. These findings are interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia...
  84. ncbi Differential splicing generates a nervous system-specific form of Drosophila neuroglian
    M Hortsch
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Neuron 4:697-709. 1990
    ....
  85. ncbi Development of nodes of Ranvier
    Jean Antoine Girault
    INSERM U 536, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
    Curr Opin Neurobiol 12:476-85. 2002
    ....
  86. ncbi Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations
    S E Hong
    Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts, USA
    Nat Genet 26:93-6. 2000
    ....
  87. ncbi Reelin gene alleles and susceptibility to autism spectrum disorders
    H Zhang
    Department of Physiology, Queens University, Kingston, ON, Canada
    Mol Psychiatry 7:1012-7. 2002
    ....
  88. ncbi Lipoprotein receptors in the nervous system
    Joachim Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Annu Rev Biochem 71:405-34. 2002
    ....
  89. pmc Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta
    T Sakurai
    Department of Pharmacology, New York University Medical Center 10016, USA
    J Cell Biol 136:907-18. 1997
    ..These results suggest that binding of glial RPTPbeta to the contactin/Nr-CAM complex is important for neurite growth and neuronal differentiation...
  90. ncbi Evolutionarily conserved, alternative splicing of reelin during brain development
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur School of Medicine, Namur, B 5000, Belgium
    Exp Neurol 156:229-38. 1999
    ..Both alternative splicing events are present in mouse, rat, and man, suggesting that the corresponding reelin forms are functionally important...
  91. pmc Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion
    A Buchstaller
    Institute of Biochemistry, University of Zurich, Switzerland
    J Cell Biol 135:1593-607. 1996
    ....
  92. ncbi The L1-type cell adhesion molecule neuroglian influences the stability of neural ankyrin in the Drosophila embryo but not its axonal localization
    M Bouley
    University of Michigan, Department of Cell and Developmental Biology, Ann Arbor, Michigan 48109 0616, USA
    J Neurosci 20:4515-23. 2000
    ..In temperature-sensitive neuroglian mutants in which neuroglian protein is mislocated at the restrictive temperature to an intracellular location in the neuronal soma, Dank2 protein can still be detected along embryonic nerve tracts...
  93. pmc Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid rafts
    Harald Mayer
    Max F Perutz Laboratories, Department of Medical Biochemistry, University Department at the Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    Mol Cell Biol 26:19-27. 2006
    ....
  94. pmc Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation
    S Kunz
    Institute of Biochemistry, University of Zurich, Switzerland
    J Cell Biol 135:253-67. 1996
    ..Thus, axonin-1 and NgCAM trigger distinctive intracellular signals during in vitro differentiation depending on their state of association...
  95. ncbi Neural cell recognition molecule F11: homology with fibronectin type III and immunoglobulin type C domains
    T Brummendorf
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Federal Republic of Germany
    Neuron 2:1351-61. 1989
    ..Both types of repeats resemble those present in neural cell adhesion molecules L1 and N-CAM. The possible identity of F11 with the chick neural glycoprotein contactin is discussed...
  96. ncbi The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells
    Ombretta Rosso
    Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Mol Cancer Res 5:1246-53. 2007
    ..Altogether, our data suggest that the disruption of ALCAM-mediated adhesion is a relevant step in EOC motility, and ADAM17/TACE takes part in this process, which may be relevant to EOC invasive potential...
  97. pmc Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily
    M P Burgoon
    Rockefeller University, New York 10021
    J Cell Biol 112:1017-29. 1991
    ..These structural features of Ng-CAM provide a framework for understanding its multiple functions in neuron-neuron interactions, neurite fasciculation, and neuron-glia interactions...
  98. ncbi Reelin activates SRC family tyrosine kinases in neurons
    Hans H Bock
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA
    Curr Biol 13:18-26. 2003
    ..However, the kinases that mediate Dab1 tyrosine phosphorylation and the intracellular pathways that are triggered by this event remain unknown...
  99. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
    ..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...
  100. pmc Bravo/Nr-CAM is closely related to the cell adhesion molecules L1 and Ng-CAM and has a similar heterodimer structure
    J F Kayyem
    California Institute of Technology, Pasadena 91125
    J Cell Biol 118:1259-70. 1992
    ....
  101. ncbi A role of MAP1B in Reelin-dependent neuronal migration
    Christian Gonzalez-Billault
    Centro de Biologia Molecular, Universidad Autonoma de Madrid CSIC, Madrid 28049, Spain
    Cereb Cortex 15:1134-45. 2005
    ..Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration...

Research Grants62

  1. CARBOHYDRATE RECOGINTION IN NEURONAL PATTERN FORMATION
    Birgit Zipser; Fiscal Year: 2002
    ..the cellular and molecular mechanisms by which cell type-specific glycosylations (markers) of neuronal cell adhesion molecules (CAMs) regulate the synaptic targeting of subsets of sensory afferents...
  2. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  3. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  4. L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETON
    Michael Hortsch; Fiscal Year: 2002
    ..Finally, he will use this assay system to test whether mutant L1-CAM molecules from human patients will function in his assay. ..
  5. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
    ....
  6. Reelin and GAD67 Downregulation
    Erminio Costa; Fiscal Year: 2005
    ....
  7. GABAergic molecular pathology in schizophrenia
    Erminio Costa; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..Identification of specific sodium channel alterations after injury may help develop more selective treatments for neuropathic pain. ..
  9. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
    ....
  10. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009
    ..abstract_text> ..
  11. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2009
    ..abstract_text> ..
  12. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    Joachim Herz; Fiscal Year: 2009
    ..This may provide novel targets for rational drug design and treatment of atherosclerosis as well as of AD, both disorders of increasing medical and socio-economic importance. ..
  13. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  14. APO E Receptors and Modulation of Fast Axonal Transport
    Joachim Herz; Fiscal Year: 2006
    ....
  15. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  16. Regulation of the Reelin Gene
    Dennis Grayson; Fiscal Year: 2006
    ....
  17. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
  18. SYNAPTIC PLASTICITY IN HIPPOCAMPAL EPILEPTOGENESIS
    Gary Clark; Fiscal Year: 2002
    ..Experiments are proposed to ascertain the role of these signal transduction mechanisms in the enhanced release of excitatory transmitter by PAF receptor activation. ..
  19. Adnesion Receptors of the Insect Immune System
    JAMES NARDI; Fiscal Year: 2003
    ..Understanding the molecular underpinnings of the insect immune response will clearly help in understanding the fate of pathogens in the blood of insect vectors of human diseases. ..
  20. PRESYNAPTIC ACTIONS OF AGRIN
    JOHN BIXBY; Fiscal Year: 2001
    ..In addition, these results will bear on the mechanism of regeneration after nervous system injury. ..
  21. Two-Photon Microscopy for Biomedical Research
    BENJAMIN REESE; Fiscal Year: 2007
    ..Acquisition of this 2-photon microscope will therefore enhance the diverse efforts of a number of investigators at UCSB in pursuit of their NIH-funded research objectives. [unreadable] [unreadable] [unreadable]..
  22. CHARACTERIZATION OF NEUROPILIN, A NOVEL VEGF RECEPTOR
    Michael Klagsbrun; Fiscal Year: 2008
    ..abstract_text> ..
  23. Structural/Trophic Hypothesis for Antidepressant Actions
    Vassilis Koliatsos; Fiscal Year: 2004
    ..abstract_text> ..
  24. HEROIN AIDS ENCEPHALOPATHY--NEUROPATHOGENESIS MECHANISMS
    Madhavan Nair; Fiscal Year: 2005
    ..Further studies will elucidate the molecular mechanisms underlying the immuno- and neuropathogenic effects of heroin use in HIV-l infection, and may yield novel therapies for the treatment of heroin using, HIV-infected patients. ..
  25. CIRCULATING INHIBITORS OF ENDOTHELIAL CELL GROWTH
    Michael Klagsbrun; Fiscal Year: 2008
    ..Currently, all angiogenesis inhibitors in clinical application are employed only after the angiogenic switch. [unreadable] [unreadable]..
  26. FACTORS REGULATING LIMBIC SYSTEM ASSEMBLY
    Aurea Pimenta; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  27. RPTPs in the Growth of Vertebrate Axons
    JOHN BIXBY; Fiscal Year: 2008
    ..This is a critical background for efforts to understand how these processes go awry in developmental disorders of the brain and spinal cord. ..
  28. The PTP, STEP, Regulates Amphetamine Actions
    Paul Lombroso; Fiscal Year: 2008
    ..We show preliminary feasibility data on this approach. A complementary set of experiments will study the STEP knock-out mouse that we predict is hypersensitive to stimulant treatment. ..
  29. FORMATION OF SPECIFIC SYNAPSES
    Samuel Schacher; Fiscal Year: 2009
    ..Failure to establish specific synaptic connections during development may contribute to several disorders of nervous system function expressed either during early life or only after maturation. ..
  30. Genes Essential To Motor Axon Guidance in Drosophila
    David Van Vactor; Fiscal Year: 2009
    ..We will use a combination of genetics, cell biology and biochemistry to determine each protein's function in axon guidance and to dissect the signaling mechanisms that regulate the key effector activities. ..
  31. AXON GUIDANCE IN THE SPINAL CORD
    Zaven Kaprielian; Fiscal Year: 2007
    ..The proposed studies should provide a basis for devising strategies aimed at directing the re-growth of regenerating nerve fibers. ..
  32. Sodium Channel Beta Subunit Cell Adhesive Interactions
    Lori L Isom; Fiscal Year: 2010
    ....
  33. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  34. Immunopathogenesis of HIV-1 Infection: Role of Methamphetamine
    Madhavan P Nair; Fiscal Year: 2010
    ....
  35. Dispersion Patterns for Retinal Neuroblasts
    BENJAMIN REESE; Fiscal Year: 2009
    ..abstract_text> ..
  36. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew W State; Fiscal Year: 2010
    ..The purpose of this study is to better understand .what causes TD by identifying additional abnormalities in the SLITRK1 gene and by investigating the impact of these unusual genetic changes on the developing brain. ..
  37. STRUCTURAL AND FUNCTIONAL ANALYSES OF NEURONAL PTPS
    Paul Lombroso; Fiscal Year: 2008
    ..STEP knock-out mice will also be characterized. The proposed investigations will be done in the supportive environment of the Child Study Center with its commitment to cliniclaly informed basic science research. ..
  38. Neuroreplacement strategies by mesenchymal stem cell
    Kiminobu Sugaya; Fiscal Year: 2007
    ..Thus, the proposed studies are expected to make a breakthrough in therapeutic strategies. ..
  39. Models of Motor Neuron Disease: Stem Cell Therapies
    Vassilis Koliatsos; Fiscal Year: 2007
    ..In concert, we propose to examine the essential preclinical parameters for the consideration of NSCs as therapeutic tools for motor neuron disease. ..
  40. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  41. Interactive multiple gene expression map for the brain
    Kiminobu Sugaya; Fiscal Year: 2005
    ..Thus, we believe that our laboratory is uniquely, qualified to pursue this current proposal. ..
  42. Arrowsmith Data Mining Techniques in Neuro-Informatics
    NEIL SMALHEISER; Fiscal Year: 2005
    ..Because of the generality of the Arrowsmith approach, it may be applied to a wide range of biomedical problems and, indeed, to conduct searches within or across any databases that contain textual material. ..
  43. INTERPLAY OF PURINERGIC & CYTOKINE SIGNALS IN HUMAN GLIA
    Celia Brosnan; Fiscal Year: 2004
    ....
  44. TRANSYNAPTIC CORTICAL APOPTOSIS--MECHANISMS & THERAPIES
    Vassilis Koliatsos; Fiscal Year: 2004
    ..We expect that these carefully controlled investigations will shed light on critical intermediate mechanisms of cortical degenerations and will suggest clinically advantageous methods to treat these disorders. ..
  45. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
    ..The patterns of developmental expression of P75/NTR, NRH1 and NRH2 will be examined in Xenopus and mice, to assess whether the opportunity for functional interactions exist. ..
  46. RNAi-Mediated Gene Suppression in Adult Mammalian CNS
    NEIL SMALHEISER; Fiscal Year: 2003
    ..These studies will pioneer the use of siRNA transfer as a potential means of selectivity knocking-down expression of neural genes, and will lay the foundation for testing the role of RNAi in learning and memory. ..
  47. IMMUNOPATHOLOGY OF HSP AND GAMMA DELTA T CELLS IN EAE
    Celia Brosnan; Fiscal Year: 2003
    ....
  48. Spatial Relationships Between Neurons in the CNS
    BENJAMIN REESE; Fiscal Year: 2005
    ..abstract_text> ..
  49. SPLICE VARIANTS OF THE HA RECEPTOR FOR ENDOCYTOSIS
    Edward Harris; Fiscal Year: 2005
    ..The significance of HARE isoforms is the potential to create a family of receptors that bind/internalize a host of different GAGs. ..
  50. GORDON RESEARCH CONFERENCE ON NEURAL DEVELOPMENT
    S Zipursky; Fiscal Year: 2002
    ..Participants will be encouraged to present posters, which serves as an excellent training and scientific function. ..
  51. Analgesic effects of adrenal chromaffin cell transplants
    George Pappas; Fiscal Year: 2007
    ..abstract_text> ..
  52. Defective PS Exposure in Neutrophil Apoptosis in CGD
    Donna Bratton; Fiscal Year: 2007
    ..It is expected that data from this investigation will identify novel potential therapeutic targets to address disordered inflammation of CGD. ..
  53. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
    ..Effects of agonistic APP monoclonal antibody, beta-amyloid peptide, LRP, and alpha-2 macroglobulin on APP signaling will be assessed. ..
  54. Analysis of Folate Receptor 4 Function in the Mouse
    J Salbaum; Fiscal Year: 2006
    ..Together, these studies will improve our understanding of the basic biology of folate receptor genes, with implications for the prevention of human birth defects. ..
  55. AIDS encephalopathy and HIV disease: role of opioids
    Madhavan Nair; Fiscal Year: 2006
    ..abstract_text> ..
  56. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2006
    ..abstract_text> ..
  57. Voltage-gated sodium channel beta subunits in zebrafish
    LORI ISOM; Fiscal Year: 2006
    ..abstract_text> ..
  58. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  59. HB-EGF AND ITS RECEPTORS
    Michael Klagsbrun; Fiscal Year: 2003
    ..abstract_text> ..
  60. Cocaine/Immuno and Neuropathogenesis of HIV-1 Infection
    Madhavan Nair; Fiscal Year: 2008
    ..These studies may lead to novel anti-HIV therapies such as targeting the CD4 independent, virus attachment receptor, DC-SIGN, or devising inhibitors of TDO and DC-SIGN or stimulating costimulatory molecules. ..
  61. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..