cd31 antigens

Summary

Summary: Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.

Top Publications

  1. ncbi Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets
    C E Edmead
    Department of Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    FEBS Lett 459:27-32. 1999
  2. ncbi Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Simon Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Nature 418:200-3. 2002
  3. pmc Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule
    S M Albelda
    Wistar Institute, Philadelphia, Pennsylvania 19104
    J Cell Biol 114:1059-68. 1991
  4. pmc A novel endothelial-specific membrane protein is a marker of cell-cell contacts
    M G Lampugnani
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Cell Biol 118:1511-22. 1992
  5. pmc Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice
    Donnasue Graesser
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 109:383-92. 2002
  6. ncbi The unfolding tale of PECAM-1
    Denise E Jackson
    Kronheimer Building, Austin Research Institute, A and RMC, Studley Road, Heidelberg, VIC 3084, Australia
    FEBS Lett 540:7-14. 2003
  7. pmc CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium
    L Piali
    Basel Institute for Immunology, Switzerland
    J Cell Biol 130:451-60. 1995
  8. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
  9. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
  10. ncbi Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
    Vidya Limaye
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Blood 105:3169-77. 2005

Research Grants

  1. PECAM-1 and Alveolization
    Horace Delisser; Fiscal Year: 2007
  2. PECAM-1'S INVOLVEMENT IN ANGIOGENESIS
    Horace Delisser; Fiscal Year: 2002
  3. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
  4. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
  5. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
  6. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
  7. Transcription Factor Reporter Technology
    Alexei Bogdanov; Fiscal Year: 2006
  8. Imaging Alpha (v)beta(3) Integrin Expression
    Xiaoyuan Chen; Fiscal Year: 2006
  9. Molecular Targets in Bronchopulmonary Dysplasia
    Richard Pierce; Fiscal Year: 2006
  10. Regulation of Microvascular Development in BPD
    William Maniscalco; Fiscal Year: 2006

Detail Information

Publications246 found, 100 shown here

  1. ncbi Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets
    C E Edmead
    Department of Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    FEBS Lett 459:27-32. 1999
    ..In addition, SHP-2 phosphatase activity is shown to be increased following thrombin stimulation or cross-linking of PECAM...
  2. ncbi Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Simon Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Nature 418:200-3. 2002
    ....
  3. pmc Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule
    S M Albelda
    Wistar Institute, Philadelphia, Pennsylvania 19104
    J Cell Biol 114:1059-68. 1991
    ..These results demonstrate that PECAM-1 mediates cell-cell adhesion and support the idea that it may be involved in some of the interactive events taking place during thrombosis, wound healing, and angiogenesis...
  4. pmc A novel endothelial-specific membrane protein is a marker of cell-cell contacts
    M G Lampugnani
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Cell Biol 118:1511-22. 1992
    ..2:261-270.) These data indicate that 7B4 antigen is an endothelial-specific cadherin that plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium...
  5. pmc Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice
    Donnasue Graesser
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 109:383-92. 2002
    ..Lastly, we demonstrate an exaggerated and prolonged CNS vascular permeability during the development of EAE and a delay in restoration of dermal vascular integrity following histamine challenge in PECAM-KO mice...
  6. ncbi The unfolding tale of PECAM-1
    Denise E Jackson
    Kronheimer Building, Austin Research Institute, A and RMC, Studley Road, Heidelberg, VIC 3084, Australia
    FEBS Lett 540:7-14. 2003
    ..In this review, we discuss some of the new developments attributed to this molecule and its unique roles in biology...
  7. pmc CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium
    L Piali
    Basel Institute for Immunology, Switzerland
    J Cell Biol 130:451-60. 1995
    ..Identification of a further versatile adhesion pair broadens our current understanding of leukocyte-endothelial interactions and may provide the basis for the treatment of inflammatory disorders and metastasis formation...
  8. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  9. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
    ..Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis...
  10. ncbi Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
    Vidya Limaye
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Blood 105:3169-77. 2005
    ....
  11. ncbi The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues
    Sussan Nourshargh
    National Heart and Lung Institute, Imperial College London, UK
    J Leukoc Biol 80:714-8. 2006
    ..In vivo data with blocking antibodies or inactivation of JAM-A and PECAM genes indicate that the role of these two proteins depends on the stimulus and the experimental model used...
  12. ncbi Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity
    Diego F Alvarez
    Department of Pharmacology, Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Lung Cell Mol Physiol 294:L419-30. 2008
    ..Thus the pulmonary microcirculation is enriched with EPCs that display vasculogenic competence while maintaining functional endothelial microvascular specificity...
  13. ncbi Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development
    H S Baldwin
    Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104
    Development 120:2539-53. 1994
    ..This is the first report of naturally occurring alternatively spliced forms of PECAM-1 having possible functional implications...
  14. ncbi Loss of PECAM-1 function impairs alveolarization
    Horace M DeLisser
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Biol Chem 281:8724-31. 2006
    ..These data suggest that the loss of PECAM-1 function compromises postnatal lung development and provide evidence that inhibition of EC function, in contrast to a loss of viable EC, inhibits alveolarization...
  15. ncbi ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration
    Miao Tzu Huang
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Blood 107:4721-7. 2006
    ..Furthermore, ICAM-2 appears capable of mediating PECAM-1-independent leukocyte transmigration...
  16. ncbi Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
    Voahanginirina Randriamboavonjy
    Vascular Signaling Group, and Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Circulation 117:52-60. 2008
    ..Platelets from patients with type 2 diabetes mellitus display hyperaggregability and increased thrombogenic potential...
  17. ncbi Molecular and functional aspects of PECAM-1/CD31
    H M DeLisser
    Dept of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104
    Immunol Today 15:490-5. 1994
    ..Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states...
  18. ncbi CD147 impacts angiogenesis and metastasis formation
    Heike Voigt
    Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
    Cancer Invest 27:329-33. 2009
    ..Thus, in the B16 melanoma model, CD147 promotes metastasis formation by induction of angiogenesis in an MMP independent manner...
  19. ncbi PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
    P J Newman
    The Blood Center of Southeastern Wisconsin, Milwaukee 53233
    Science 247:1219-22. 1990
    ..This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events...
  20. ncbi The alpha-isoform of caveolin-1 is a marker of vasculogenesis in early lung development
    Maria I Ramirez
    Pulmonary Center, Departments of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Histochem Cytochem 50:33-42. 2002
    ..Caveolin-1alpha is an early marker for lung vasculogenesis, primarily expressed in developing blood vessels. When the lung is fully differentiated postnatally, caveolin-1alpha is also expressed in alveolar Type I cells...
  21. ncbi Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer
    M I Koukourakis
    Department of Radiotherapy Oncology, University Hospital of Iraklion, Crete, Greece
    Cancer Res 60:3088-95. 2000
    ..Clinical trials involving targeting of the VEGF/KDR-positive vasculature with specific antibodies, such as 11B5, are, therefore, encouraged...
  22. pmc Involvement of endothelial PECAM-1/CD31 in angiogenesis
    H M DeLisser
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Am J Pathol 151:671-7. 1997
    ..Taken together these findings provide evidence that PECAM-1 is involved in angiogenesis and suggest that the interactions of endothelial cell-cell adhesion molecules are important in the formation of new vessels...
  23. ncbi Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas
    Tarsila M C Freitas
    Dentistry School, Federal University of Rio Grande do Norte, Departamento de Odontologia, Programa de Pós graduação em Patologia Oral, Av Salgado Filho 1787, Lagoa Nova, Natal RN 59056 000, Brazil
    Exp Mol Pathol 79:79-85. 2005
    ..These results effort the role of the angiogenic factors in the etiopathogenesis of the hemangiomas and pyogenic granulomas, however, it showed that microvessel quantification is not useful in the differential diagnosis of these lesions...
  24. ncbi Is PECAM-1 a mechanoresponsive molecule?
    K Fujiwara
    Center for Cardiovascular Research, Department of Medicine, University of Rochester, NY 14624, USA
    Cell Struct Funct 26:11-7. 2001
    ..This PE-CAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells...
  25. ncbi Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck)
    D K Newman
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53233, USA
    Blood 97:2351-7. 2001
    ..Finally, PECAM-1 failed to become tyrosine phosphorylated in p56(lck)-deficient Jurkat T cells. Together, these data provide important insights into the molecular requirements for PECAM-1 regulation of antigen receptor signaling...
  26. ncbi Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse
    N Ilan
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA
    Dev Biol 232:219-32. 2001
    ..We suggest that by serving as a scaffolding, PECAM-1 can bring substrates (STAT5a) and enzymes (a kinase) into close proximity, thereby modulating phosphorylation levels of selected proteins, as previously noted for beta-catenin...
  27. ncbi Identification of the regions of PECAM-1 involved in beta- and gamma-catenin associations
    Purba Biswas
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Biochem Biophys Res Commun 329:1225-33. 2005
    ....
  28. pmc Molecular characterization of lymphatic endothelial cells
    Simona Podgrabinska
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 99:16069-74. 2002
    ....
  29. ncbi PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 25:1590-5. 2005
    ....
  30. ncbi The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo
    W A Muller
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
    J Leukoc Biol 57:523-8. 1995
    ..Thus, PECAM-1 has a distinct role in the transendothelial migration phase of leukocyte emigration, independent of the adhesion events on the apical surface...
  31. ncbi Molecular characterization and functional analysis of the leukocyte surface protein CD31
    H Stockinger
    Institute of Immunology Vienna International Research Cooperation Center at SFI, University of Vienna
    J Immunol 145:3889-97. 1990
    ..We show that signal transduction occurs via formation of a CD31 Ag-mAb-Fc gamma R complex involving either Fc gamma RI (CD64) or Fc gamma RII (CDw32) molecules...
  32. ncbi Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases
    M Y Cao
    McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 273:15765-72. 1998
    ....
  33. pmc Microvessel quantification in primary colorectal carcinoma: an immunohistochemical study
    P B Vermeulen
    Laboratory of Cancer Research and Clinical Oncology, University of Antwerp, Belgium
    Br J Cancer 71:340-3. 1995
    ....
  34. pmc PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation
    Purba Biswas
    Department of Pathology, Yale University School of Medicine, 310 Cedar St, Lauder Hall, Rm L115, New Haven, CT 06520, USA
    Am J Pathol 169:314-24. 2006
    ....
  35. ncbi Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is localized over the entire plasma membrane of endothelial cells
    D Scholz
    Max Planck Institute, Department of Experimental Cardiology, Benekestrasse 2, D 61231 Bad Nauheim, Germany
    Cell Tissue Res 290:623-31. 1997
    ..In view of these findings, the role of PECAM-1 in the leukocyte migration cascade needs to be re-evaluated...
  36. ncbi Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study
    Ilse Van der Auwera
    Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Clin Cancer Res 11:7637-42. 2005
    ..The objective of this study was twofold: (a) to determine which is the most suitable marker of lymph vessels in primary breast tumors and (b) to compare histomorphometric lymph vessel variables in IBC and non-IBC...
  37. ncbi Endothelial cell-cell adhesion and mechanosignal transduction
    Yi Jen Chiu
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endothelium 11:59-73. 2004
    ..We will also review the available evidence for PECAM-1 as a mechanotransducing molecule in endothelial cells...
  38. pmc PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells
    Guangju Ji
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Cell Biol 157:173-84. 2002
    ..PECAM-1-dependent H2O2 currents and associated [Ca2+]i transients may play a significant role in regulating neutrophil-endothelial interaction, as well as in oxidant-mediated endothelial response and injury...
  39. ncbi Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues
    Marc P Pusztaszeri
    Institute of Pathology, Rue du Bugnon 25 1011, Lausanne, Switzerland
    J Histochem Cytochem 54:385-95. 2006
    ..The expression of EC markers CD31, CD34, and vWF in the vascular tree is heterogeneous with a specific pattern for individual vessel types and different anatomic compartments of the same organ. D2-40 labels lymphatic EC only...
  40. ncbi Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1)
    H C Yan
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    J Biol Chem 270:23672-80. 1995
    ....
  41. ncbi Differential assessment of vascular survival ability and tumor angiogenic activity in colorectal cancer
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Clin Cancer Res 8:1185-91. 2002
    ..This "vascular survival" potential can be assessed by comparatively examining the vascular density in peripheral and inner tumor areas...
  42. ncbi Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif
    Dita Gratzinger
    Department of Pathology, Yale University School of Medicine, Lauder Hall 115, 310 Cedar St, New Haven, CT 06511, USA
    Biochem Biophys Res Commun 301:243-9. 2003
    ....
  43. ncbi Src homology 2 domain-containing protein-tyrosine phosphatases, SHP-1 and SHP-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signaling
    T L Henshall
    Division of Haematology, Hanson Centre for Cancer Research, IMVS, Adelaide, South Australia
    J Immunol 166:3098-106. 2001
    ....
  44. ncbi CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated
    J P Newton
    Cell Adhesion Laboratory, Institute of Molecular Medicine, Headington, OX3 9DU, United Kingdom
    Biochem Biophys Res Commun 261:283-91. 1999
    ..Chemical cross-linking studies of both soluble and membrane-expressed CD31 confirmed that CD31 exists as a dimer. These studies suggest that, like E-cadherin, PECAM-dimerization is likely to play a role in CD31 adhesion and signaling...
  45. ncbi PECAM-1: old friend, new partners
    Neta Ilan
    Department of Vascular Biology, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Curr Opin Cell Biol 15:515-24. 2003
    ....
  46. pmc Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?
    Masaki Osawa
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cell Biol 158:773-85. 2002
    ..Binding of the beads by itself or pulling on the cell surface using poly-l-coated beads did not induce phosphorylation of PECAM-1 and ERK. These results suggest that PECAM-1 is a mechanotransduction molecule...
  47. ncbi Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer
    Ferenc Renyi-Vamos
    Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary
    Clin Cancer Res 11:7344-53. 2005
    ..Our aim was to assess the lymphangiogenesis of human NSCLC, and to correlate this with angiogenic phenotype (angiogenic versus nonangiogenic growth pattern) and clinical behavior...
  48. ncbi CD99 plays a major role in the migration of monocytes through endothelial junctions
    Alan R Schenkel
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:143-50. 2002
    ..Therefore, diapedesis, the forward migration of leukocytes through endothelial junctions, is regulated sequentially by two distinct molecules, PECAM-1 and CD99...
  49. ncbi Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration
    Gaoyuan Cao
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Am J Physiol Cell Physiol 282:C1181-90. 2002
    ....
  50. pmc PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane
    John Dangerfield
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Exp Med 196:1201-11. 2002
    ....
  51. ncbi Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+ circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation
    Elisabetta Ferrero
    Laboratory of Tumor Immunology, the Human Virology Unit, DIBIT, Italy
    Blood 101:186-93. 2003
    ....
  52. ncbi Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury
    Janette Glaser
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California at Irvine, Irvine, California 92697, USA
    J Neurosci Res 77:701-8. 2004
    ..Improved blood flow and oxygen supply to the injury site may contribute to the functional improvement associated with this treatment...
  53. ncbi Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis
    Bernard Uzzan
    Laboratoire de Pharmacologie Hôpital Avicenne, Bobigny, France
    Cancer Res 64:2941-55. 2004
    ..MVD was a significant although weak prognostic factor in women with breast cancer. Standardization of MVD assessment is needed...
  54. ncbi Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis
    Jasenka Mazibrada
    Department of Public Health and Microbiology, Medical School of Turin, Turin, Italy
    Gynecol Oncol 108:112-20. 2008
    ..The primary aim of this study was to investigate the role of angiogenesis and inflammatory cell response in cervical carcinogenesis...
  55. ncbi A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction
    D K Newton-Nash
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee 53233, USA
    J Immunol 163:682-8. 1999
    ..These data provide evidence that PECAM-1 can dampen signals transduced by ITAM-containing receptors and support inclusion of PECAM-1 within the family of ITIM-containing inhibitors of PTK-dependent signal transduction...
  56. ncbi Short report: codon 125 polymorphism of CD31 and susceptibility to malaria
    C Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Am J Trop Med Hyg 65:736-7. 2001
    ....
  57. ncbi Cross-talk between cell adhesion molecules regulates the migration velocity of neutrophils
    G E Rainger
    Department of Physiology, The Medical School, The University of Birmingham, Birmingham, B15 2TT, UK
    Curr Biol 7:316-25. 1997
    ..Signals from chemotactic agents and from the adhesive substrate may regulate these processes, but little is known about their relative importance or their mode of integration...
  58. ncbi Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets
    Milenko Cicmil
    School of Animal and Microbial Sciences, University of Reading, United Kingdom
    Blood 99:137-44. 2002
    ..These data suggest that PECAM-1 may play a role in the regulation of platelet function in vivo...
  59. ncbi Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils
    F Pellegatta
    Laboratory of Cardiovascular Pathophysiology, Department of Cardiology, Scientific Institute San Raffaele, Instituto di Ricovero e Cura a Carattere Scientifico, I 20132 Milan, Italy
    J Biol Chem 273:27768-71. 1998
    ..In conclusion, PECAM-1/CD31 appears to be one of the molecules functionally coupled to PI3K, suggesting that this enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes...
  60. ncbi Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression
    J Sun
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Biol Chem 271:18561-70. 1996
    ..These data suggest that PECAM-1-ligand interactions can be regulated through multiple pathways including alterations of the cytoplasmic domain and the level of surface expression...
  61. pmc Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state
    E Pinter
    Departments of Pathology and Pediatrics, Yale University, Alexion Pharmaceuticals, Inc, New Haven, Connecticut, USA
    Am J Pathol 154:1367-79. 1999
    ....
  62. ncbi Vascular-endothelial-cadherin modulates endothelial monolayer permeability
    P L Hordijk
    Dept of Experimental Immunohematology, CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam
    J Cell Sci 112:1915-23. 1999
    ..Together, these data show that monolayer permeability and neutrophil transendothelial migration are modulated by VE-cadherin-mediated cell-cell adhesion, which is in turn controlled by the dynamics of the actin cytoskeleton...
  63. ncbi Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers
    Rahmawati Minhajat
    Department of Pathology and Biodefense, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Virchows Arch 448:127-34. 2006
    ..The present study shows that de novo blood vessels of colon cancer specifically express CD105. These findings provide the basis for novel antiangiogenic cancer therapies...
  64. pmc Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice
    Michael Carrithers
    Department of Neurology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520, USA
    Am J Pathol 166:185-96. 2005
    ..These results suggest that CD31 is necessary for maintenance of endothelial integrity and prevention of apoptosis during septic shock and for STAT3-mediated acute phase responses that promote survival during septic shock...
  65. ncbi Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is associated with increased angiogenic potential in non-small-cell lung cancer
    Sebastian Dango
    Department of Thoracic Surgery, Albert Ludwigs University Freiburg, 79106 Freiburg, Germany
    Lung Cancer 60:426-33. 2008
    ..1-4.0). Here we show for the first time that high CEACAM-1 expression is associated with an increased angiogenic activity in NSCLC, and that the prognostic influence of CEACAM-1 might be derived from this association...
  66. ncbi Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome
    Jean Philippe Dales
    Service d Anatomie et de Cytologie Pathologiques, Hopital Nord, 13915 Marseille Cedex 20, France
    Int J Oncol 24:1197-204. 2004
    ....
  67. ncbi CD31 regulates direction and rate of neutrophil migration over and under endothelial cells
    N Thin Luu
    Department of Physiology, The Medical School, The University of Birmingham, Birmingham, UK
    J Vasc Res 40:467-79. 2003
    ..Thus mechanical and adhesive signals can regulate neutrophil migration driven by locally-acting chemotactic agents...
  68. ncbi Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais
    M Kikuchi
    Department of Medical Zoology, Saitama Medical School, Moroyrma, Iruma, 350 0495, Saitama, Japan
    Parasitol Int 50:235-9. 2001
    ..We found that the frequency of the 125 V/V 563 N/N genotype was significantly high in CM patients as compared with severe cases without CM (P<0.01, OR=2.92), suggesting that this genotype is one of the risk factors for CM...
  69. pmc PECAM-1 (CD31) expression modulates bleeding time in vivo
    S Mahooti
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Am J Pathol 157:75-81. 2000
    ..These studies are consistent with a role for PECAM-1 in modulating thrombosis in the vasculature, which is potentially mediated by endothelial cell PECAM-1 expression...
  70. ncbi Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells
    M Masuda
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    FEBS Lett 408:331-6. 1997
    ..Our results suggest that PECAM-1 is a component of a mechanosensing machinery acting upstream of SH-PTP2...
  71. ncbi The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)
    K Sagawa
    Receptors and Signal Transduction Section, OIIB, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:31086-91. 1997
    ..Therefore, integrin and immune receptor activation results in tyrosine phosphorylation of PECAM-1 and the binding of the protein-tyrosine phosphatase SHP-2, which could regulate receptor-mediated signaling in cells...
  72. ncbi Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease
    E Behar
    Department of Pathology, Stanford University, Calif, USA
    N Engl J Med 334:286-91. 1996
    ..e., other than HLA) histocompatibility antigens remains a serious problem in recipients of bone marrow transplants. We sought to determine whether the CD31 adhesion molecule is a minor alloantigen...
  73. ncbi Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats
    Stephen J Peterson
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 322:514-20. 2007
    ....
  74. ncbi Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases
    M Cicmil
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, United Kingdom
    J Biol Chem 275:27339-47. 2000
    ..The involvement of Src family kinases in this process was confirmed through the study of mouse platelets deficient in Fyn...
  75. ncbi Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo
    A A Vaporciyan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    Science 262:1580-2. 1993
    ..On the basis of these findings in three different models of inflammation, it appears that PECAM-1 is required for neutrophil transmigration in vivo and may thus be a potential therapeutic target...
  76. ncbi Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily
    F Listi
    Gruppo di Studio sull Immunosenescenza, Dipartiento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
    Eur J Immunogenet 31:175-8. 2004
    ..All in all, we believe that the results of the present study would add support to the role of pro/anti-inflammatory genotypes in determining susceptibility or resistance to immune-inflammatory diseases, including atherosclerosis...
  77. ncbi Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse
    Mariarosaria Galeano
    Department of ClinicalExperimental Medicine, Section of Pharmacology, Azienda Ospedaliera Universitaria G Martino, Torre Biologica, 5th Floor, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Diabetes 53:2509-17. 2004
    ..05). Erythropoietin may have a potential application in diabetes-related wound disorders...
  78. ncbi Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions
    G S Duncan
    Amgen Institute, Toronto, Ontario, Canada
    J Immunol 162:3022-30. 1999
    ..This study provides genetic evidence that CD31 is involved in transbasement membrane migration, but does not play an obligatory role in either vascular development or leukocyte migration...
  79. ncbi Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2
    Lung Kuo Tai
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, New York 14642, USA
    J Biol Chem 280:29620-4. 2005
    ..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction...
  80. ncbi The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis
    Mae Xhum Wong
    Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    J Clin Immunol 25:19-28. 2005
    ..Together these observations suggest that PECAM-1 plays a crucial role in the suppression of development of autoimmune arthritis...
  81. ncbi Molecular basis of the effects of shear stress on vascular endothelial cells
    Yi Shuan J Li
    Department of Bioengineering, University of California, San Diego, La Jolla, 92093 0412, USA
    J Biomech 38:1949-71. 2005
    ..The knowledge gained on mechano-transduction, with verifications under in vivo conditions, will advance our understanding of the physiological and pathological processes in vascular remodeling and adaptation in health and disease...
  82. ncbi Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31
    N J Pumphrey
    Division of Immunity and Infection, University of Birmingham, UK
    FEBS Lett 450:77-83. 1999
    ....
  83. ncbi Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates
    C T Hua
    Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000 Australia
    J Biol Chem 273:28332-40. 1998
    ....
  84. ncbi High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
    Petri Bono
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    Clin Cancer Res 10:7144-9. 2004
    ..LYVE-1, a lymphatic endothelium-specific hyaluronan receptor, is a novel lymphatic vessel marker that is expressed on lymph vessel endothelial cells of both normal and neoplastic tissues...
  85. ncbi Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains
    Alan R Schenkel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 173:6403-8. 2004
    ..Murine models of inflammatory disease that have been studied using C57BL/6 mice should be re-evaluated using FVB/n or other mouse strains to determine whether PECAM plays a role in those models...
  86. ncbi Improved therapeutic effectiveness by combining recombinant CXC chemokine ligand 10 with Cisplatin in solid tumors
    Gang Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, The People s Republic of China
    Clin Cancer Res 11:4217-24. 2005
    ..CXC chemokine ligand 10 (CXCL10) is a potent inhibitor of angiogenesis. We wonder whether the combination of CXCL10 with cisplatin would improve the therapeutic antitumor efficacy...
  87. ncbi PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets
    Vipul Rathore
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
    Blood 102:3658-64. 2003
    ....
  88. ncbi Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology
    Peter J Newman
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, Wis 53201, USA
    Arterioscler Thromb Vasc Biol 23:953-64. 2003
    ....
  89. pmc Minimal regulation of platelet activity by PECAM-1
    Tarvinder S Dhanjal
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Platelets 18:56-67. 2007
    ....
  90. ncbi Nerve growth factor expression and innervation of the painful intervertebral disc
    A J Freemont
    Manchester University, UK
    J Pathol 197:286-92. 2002
    ..These did not express NGF nor did nerves accompany them. These findings show that nociceptive nerve ingrowth into painful IVD is causally linked with NGF production by blood vessels growing into the IVD, from adjacent vertebral bodies...
  91. ncbi Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes
    Pedro Viegas
    Institut Cochin, Département Biologie Cellulaire, Paris, France
    J Cell Sci 119:4634-43. 2006
    ..Our results strongly support the conclusion that PrP(C) is expressed by brain endothelium as a junctional protein that is involved in the trans-endothelial migration of monocytes...
  92. ncbi The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization
    Raquel Lima e Silva
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    FASEB J 21:3219-30. 2007
    ..They provide new targets for therapeutic intervention that may help to bolster and supplement effects obtained with VEGF antagonists...
  93. ncbi Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis
    Zahra Mamdouh
    Department of Pathology and Laboratory Medicine, Weill Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nature 421:748-53. 2003
    ..In addition, blockade of TEM with antibodies against PECAM specifically blocks the recruitment of this membrane to the zones of leukocyte migration, without affecting the constitutive membrane trafficking...
  94. ncbi Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions
    K L Jones
    Division of Haematology, Hanson Centre for Cancer Research, IMVS, Adelaide, Australia
    Blood 98:1456-63. 2001
    ..Collectively, these results indicate that PECAM-1 serves as a physiological negative regulator of platelet-collagen interactions that may function to negatively limit growth of platelet thrombi on collagen surfaces...
  95. ncbi Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation
    Mae Xhum Wong
    Division of Hematology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Immunol 168:6455-62. 2002
    ..These results suggest that PECAM-1 acts as a counterregulator in allergic disease susceptibility and severity and negatively modulates mast cell activation...
  96. ncbi Plasticity of human adipose stem cells to perform adipogenic and endothelial differentiation
    Melanie Wosnitza
    Department of Plastic Surgery and Hand Surgery Burn Center, University Hospital of the Aachen University of Technology, Pauwelsstr 30, 52057 Aachen, Germany
    Differentiation 75:12-23. 2007
    ..Further, they reveal the plasticity of mature cells of mesenchymal origin to undergo conversion from endothelium to adipose tissue and vice versa...
  97. ncbi Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase C gamma 2 activation by Src family kinases
    T Ohmori
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi 409-3898, Japan
    Biochemistry 40:12992-3001. 2001
    ....
  98. ncbi Evaluation of CD31 (PECAM-1) expression using tissue microarray in patients with renal cell carcinoma
    Johanna Sandlund
    Division of Oncology, Department of Radiation Sciences, Umea University, Umea, Sweden
    Tumour Biol 28:158-64. 2007
    ..A multivariate analysis of prognostic factors in conventional RCC showed that TNM stage and nuclear grade were independent predictors of prognosis, but CD31 expression did not add further prognostic information...
  99. pmc CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion
    Y Tanaka
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 176:245-53. 1992
    ..We propose that, in collaboration with other receptors/ligands, CD31 functions in an "adhesion cascade" by amplifying integrin-mediated adhesion of CD31+ T cells to other cells, particularly endothelial cells...
  100. pmc Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies
    F Andreotti
    Institute of Cardiology, Catholic University, Rome, Italy
    Heart 87:107-12. 2002
    ..Although they are very preliminary and partly conflicting, the data provide some evidence that alterations in the genetics of the inflammatory system may modify the risk of ischaemic heart disease...
  101. ncbi The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signal
    D E Jackson
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53233 2121, USA
    J Biol Chem 272:6986-93. 1997
    ....

Research Grants56

  1. PECAM-1 and Alveolization
    Horace Delisser; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. PECAM-1'S INVOLVEMENT IN ANGIOGENESIS
    Horace Delisser; Fiscal Year: 2002
    ....
  3. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
  5. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
  6. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  7. Transcription Factor Reporter Technology
    Alexei Bogdanov; Fiscal Year: 2006
    ..abstract_text> ..
  8. Imaging Alpha (v)beta(3) Integrin Expression
    Xiaoyuan Chen; Fiscal Year: 2006
    ..abstract_text> ..
  9. Molecular Targets in Bronchopulmonary Dysplasia
    Richard Pierce; Fiscal Year: 2006
    ..These studies will be highly interactive within the Consortium and provide gene expression data for the scientific community at large. ..
  10. Regulation of Microvascular Development in BPD
    William Maniscalco; Fiscal Year: 2006
    ..New data from this proposal will be essential for developing novel therapies for BPD. ..
  11. Thrombostatin-A Thrombin Receptor Inhibitor
    Alvin Schmaier; Fiscal Year: 2006
    ..Second, the preparation of an IND application for its human use for one indication will be achieved. Thrombostatin(tm) has the opportunity to be a first-in-its-class thrombin receptor activation antagonist. [unreadable] [unreadable]..
  12. Expression Analysis of Prostate Cancer
    Phillip Febbo; Fiscal Year: 2006
    ....
  13. AUGMENTATION OF ANTIOXIDANT DEFENSES BY IMMUNOTARGETING
    Vladimir Muzykantov; Fiscal Year: 2007
    ..The overall goal of this proposal is to optimize strategies for vascular AOE targeting, to ultimately initiate translation of this strategy into the clinical domain. ..
  14. PPARg in trophoblast and placental development
    DAVID MILSTONE; Fiscal Year: 2007
    ..These studies will provide significant new mechanistic information about the role of PPARgamma in placentation, and may suggest future therapeutic possibilities for gestational disease in patients. ..
  15. Integrating Cell Division and Morphogenesis in Developing Vessels
    Victoria L Bautch; Fiscal Year: 2010
    ..The results will help us understand how vessels are shaped, which in turn will aid in designing ways to make artificial vessels for therapeutic use. ..
  16. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ....
  17. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..
  18. Viral-Driven Mediators of Chronic Lung Allograft Dysfunction
    Richard Pierce; Fiscal Year: 2009
    ..This research will study how these viruses cause chronic lung rejection so that treatments for this condition can be developed. (End of Abstract) ..
  19. Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Combined MRI and Optical Imaging to Improved Breast Cancer Diagnosis
    Min Ying Su; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. Biomarkers for VEGF and mTOR Blockade in Advanced Renal Cancer
    Jaime Merchan; Fiscal Year: 2007
    ..This information will be extremely useful for the design of future trials using these agents in renal and other cancers and for future clinical practice. [unreadable] [unreadable] [unreadable]..
  22. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. VEGF and Nitric Oxide in Lung Vascular Development
    Vivek Balasubramaniam; Fiscal Year: 2007
    ..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
  24. Cyclic Follicle Function and Angiogenesis
    Ralf Zimmermann; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  25. CYTOKINE REGULATION OF EARLY EVENTS IN BLOOD VESSEL FORM
    Christopher Drake; Fiscal Year: 2006
    ..abstract_text> ..
  26. Molecular Mechanisms of Glucocortoid Resistance: Relevance to Mood Disorders
    Xiaohong Wang; Fiscal Year: 2004
    ..Moreover, insights gained from the proposed research will contribute to the development of novel therapeutic targets for the treatment of mood disorders. ..
  27. NOVEL TYROSINASE MUTANTS AS IMAGING MARKER GENES
    Alexei Bogdanov; Fiscal Year: 2002
    ..The long-term goal of this research is to explore and develop novel and useful bifunctional "imaging/therapeutic marker genes" for in vivo use. ..
  28. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  29. THROMBOPROPHYLAXIS IN THE SURGICAL SETTING
    Vladimir Muzykantov; Fiscal Year: 2004
    ..The results of this study may provide new means to achieve thromboprophylaxis in surgical settings such as angioplasty and endarterectomy, as well as be a platform for the development of novel forms of antithrombotic therapy. ..
  30. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003
    ..These studies could serve as a basis for the development of a global assay(s) to predict the prothrombotic state in man. (End of Abstract.) ..
  31. Role of SV40 in Salivary Gland Tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2003
    ..Analysis of molecular changes occurring during salivary gland tumorigenesis may lead to the development of therapeutic agents for the treatment of malignant disease. ..
  32. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
    ..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
  33. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  34. CONSTRUCTION OF BIOLOGY RESEARCH FACILITY
    DIPAK SARKAR; Fiscal Year: 2002
    ..abstract_text> ..
  35. FN FAK SIGNALING AXIS AND TUMORIGENESIS
    Dusko Ilic; Fiscal Year: 2004
    ..abstract_text> ..
  36. A LONGITUDINAL STUDY IN THE CANINE MODEL OF HUMAN AGING
    Min Ying Su; Fiscal Year: 2005
    ..Noninvasive MR imaging techniques may offer a means of detecting early signs of pathological aging, allowing us the opportunity to initiate interventions to slow disease progression. ..
  37. ADHESION MOLECULES IN NO MODULATED TUMORIGENESIS
    LESLEY ELLIES; Fiscal Year: 2004
    ..These studies will help to define t h e importance of NO mediated alterations in adhesion molecules in tumorigenesis and may lead to improved therapy for cancer patients. ..
  38. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  39. Nanocarriers for delivery of antioxidants to endothelium
    Vladimir Muzykantov; Fiscal Year: 2004
    ..Completion of these Aims will be a major step towards the long-term goal of our research, which is translation of this promising new technology platform into the clinical domain. ..
  40. Regulatory elements controlling elastin transcription
    Richard Pierce; Fiscal Year: 2005
    ..These approaches will reveal key mechanisms controlling elastin synthesis and identify targets for strategies to modulate elastin synthesis in the lungs of premature infants and in pulmonary emphysema. ..
  41. Targeting of Drugs to ICAM
    Vladimir Muzykantov; Fiscal Year: 2005
    ..This study will extend and strengthen the ICAM-directed vascular immunotargeting paradigm that may be used for a prophylaxis and therapies of diverse pulmonary and cardiovascular diseases, in particular, ALl. ..
  42. PECAM AND CALCIUM SIGNALING AND TRANSMIGRATION
    Steven Albelda; Fiscal Year: 2002
    ....
  43. Ras/Rap Signaling and Endothelial Morphogenesis
    Victoria Bautch; Fiscal Year: 2009
    ..abstract_text> ..
  44. Integrating Cell Division and Morphogenesis in Vessels
    Victoria Bautch; Fiscal Year: 2004
    ..This work should provide a strong framework to begin to understand how cell division and morphogenesis are integrated during blood vessel formation, information critical to reconstituting the process for therapeutic uses. ..
  45. The Role of PECAM in Models of Lung Injury
    Steven Albelda; Fiscal Year: 2005
    ..These studies will fill a gap in the basic understanding of lung and cell adhesion biology, as well as provide potentially useful therapeutic information. ..
  46. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..
  47. CYCLOOXYGENASE-2 AND XENOBIOTICS IN VASCULAR INJURY
    Babette Weksler; Fiscal Year: 2005
    ..abstract_text> ..
  48. "Vasculata 2007" Conference grant application
    Victoria Bautch; Fiscal Year: 2007
    ..We are particularly interested in reaching out to minority participants and providing them with full scholarships. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  49. MicroPET and NIR Fluorescence Imaging Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2004
    ..All the results obtained here will be used for future application of a R01 type grant. ..
  50. EMAP II Regulation of Pulmonary Cell Proliferation
    MARGARET SCHWARZ; Fiscal Year: 2007
    ..abstract_text> ..
  51. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  52. Vasculature is a determinant of epithelial morphogenesis
    MARGARET SCHWARZ; Fiscal Year: 2006
    ..Thus, identifying the factors responsible for coordinating vascular formation and distal lung morphogenesis will provide insight into the determinants by which their balance can affect lung development. ..
  53. Tumor Antigen Discovery in ALL by Expression Profiling
    WILLIAM HAINING; Fiscal Year: 2006
    ..This training will form the foundation of my career in translational research. ..
  54. Molecular Diagnosis of Defective Memory Differentiation in Tumor-Specific T Cells
    WILLIAM HAINING; Fiscal Year: 2008
    ..This will help identify the molecular basis for defective tumor-specific immunity, and provide a novel assay to predict immune response to cancer immunotherapy. [unreadable] [unreadable] [unreadable]..