Genomes and Genes
Summary: Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
Publications246 found, 100 shown here
- Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human plateletsC E Edmead
Department of Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
FEBS Lett 459:27-32. 1999..In addition, SHP-2 phosphatase activity is shown to be increased following thrombin stimulation or cross-linking of PECAM...
- Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfmentSimon Brown
Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
Nature 418:200-3. 2002....
- Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion moleculeS M Albelda
Wistar Institute, Philadelphia, Pennsylvania 19104
J Cell Biol 114:1059-68. 1991..These results demonstrate that PECAM-1 mediates cell-cell adhesion and support the idea that it may be involved in some of the interactive events taking place during thrombosis, wound healing, and angiogenesis...
- A novel endothelial-specific membrane protein is a marker of cell-cell contactsM G Lampugnani
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
J Cell Biol 118:1511-22. 1992..2:261-270.) These data indicate that 7B4 antigen is an endothelial-specific cadherin that plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium...
- Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient miceDonnasue Graesser
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
J Clin Invest 109:383-92. 2002..Lastly, we demonstrate an exaggerated and prolonged CNS vascular permeability during the development of EAE and a delay in restoration of dermal vascular integrity following histamine challenge in PECAM-KO mice...
- The unfolding tale of PECAM-1Denise E Jackson
Kronheimer Building, Austin Research Institute, A and RMC, Studley Road, Heidelberg, VIC 3084, Australia
FEBS Lett 540:7-14. 2003..In this review, we discuss some of the new developments attributed to this molecule and its unique roles in biology...
- CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endotheliumL Piali
Basel Institute for Immunology, Switzerland
J Cell Biol 130:451-60. 1995..Identification of a further versatile adhesion pair broadens our current understanding of leukocyte-endothelial interactions and may provide the basis for the treatment of inflammatory disorders and metastasis formation...
- A role for hematopoietic stem cells in promoting angiogenesisN Takakura
Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
Cell 102:199-209. 2000..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
- A mechanosensory complex that mediates the endothelial cell response to fluid shear stressEleni Tzima
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 437:426-31. 2005..Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis...
- Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family membersVidya Limaye
Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
Blood 105:3169-77. 2005....
- The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissuesSussan Nourshargh
National Heart and Lung Institute, Imperial College London, UK
J Leukoc Biol 80:714-8. 2006..In vivo data with blocking antibodies or inactivation of JAM-A and PECAM genes indicate that the role of these two proteins depends on the stimulus and the experimental model used...
- Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacityDiego F Alvarez
Department of Pharmacology, Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
Am J Physiol Lung Cell Mol Physiol 294:L419-30. 2008..Thus the pulmonary microcirculation is enriched with EPCs that display vasculogenic competence while maintaining functional endothelial microvascular specificity...
- Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular developmentH S Baldwin
Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104
Development 120:2539-53. 1994..This is the first report of naturally occurring alternatively spliced forms of PECAM-1 having possible functional implications...
- Loss of PECAM-1 function impairs alveolarizationHorace M DeLisser
Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
J Biol Chem 281:8724-31. 2006..These data suggest that the loss of PECAM-1 function compromises postnatal lung development and provide evidence that inhibition of EC function, in contrast to a loss of viable EC, inhibits alveolarization...
- ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigrationMiao Tzu Huang
Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Blood 107:4721-7. 2006..Furthermore, ICAM-2 appears capable of mediating PECAM-1-independent leukocyte transmigration...
- Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazoneVoahanginirina Randriamboavonjy
Vascular Signaling Group, and Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
Circulation 117:52-60. 2008..Platelets from patients with type 2 diabetes mellitus display hyperaggregability and increased thrombogenic potential...
- Molecular and functional aspects of PECAM-1/CD31H M DeLisser
Dept of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104
Immunol Today 15:490-5. 1994..Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states...
- CD147 impacts angiogenesis and metastasis formationHeike Voigt
Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
Cancer Invest 27:329-33. 2009..Thus, in the B16 melanoma model, CD147 promotes metastasis formation by induction of angiogenesis in an MMP independent manner...
- PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamilyP J Newman
The Blood Center of Southeastern Wisconsin, Milwaukee 53233
Science 247:1219-22. 1990..This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events...
- The alpha-isoform of caveolin-1 is a marker of vasculogenesis in early lung developmentMaria I Ramirez
Pulmonary Center, Departments of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Histochem Cytochem 50:33-42. 2002..Caveolin-1alpha is an early marker for lung vasculogenesis, primarily expressed in developing blood vessels. When the lung is fully differentiated postnatally, caveolin-1alpha is also expressed in alveolar Type I cells...
- Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancerM I Koukourakis
Department of Radiotherapy Oncology, University Hospital of Iraklion, Crete, Greece
Cancer Res 60:3088-95. 2000..Clinical trials involving targeting of the VEGF/KDR-positive vasculature with specific antibodies, such as 11B5, are, therefore, encouraged...
- Involvement of endothelial PECAM-1/CD31 in angiogenesisH M DeLisser
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Am J Pathol 151:671-7. 1997..Taken together these findings provide evidence that PECAM-1 is involved in angiogenesis and suggest that the interactions of endothelial cell-cell adhesion molecules are important in the formation of new vessels...
- Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomasTarsila M C Freitas
Dentistry School, Federal University of Rio Grande do Norte, Departamento de Odontologia, Programa de Pós graduação em Patologia Oral, Av Salgado Filho 1787, Lagoa Nova, Natal RN 59056 000, Brazil
Exp Mol Pathol 79:79-85. 2005..These results effort the role of the angiogenic factors in the etiopathogenesis of the hemangiomas and pyogenic granulomas, however, it showed that microvessel quantification is not useful in the differential diagnosis of these lesions...
- Is PECAM-1 a mechanoresponsive molecule?K Fujiwara
Center for Cardiovascular Research, Department of Medicine, University of Rochester, NY 14624, USA
Cell Struct Funct 26:11-7. 2001..This PE-CAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells...
- Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck)D K Newman
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53233, USA
Blood 97:2351-7. 2001..Finally, PECAM-1 failed to become tyrosine phosphorylated in p56(lck)-deficient Jurkat T cells. Together, these data provide important insights into the molecular requirements for PECAM-1 regulation of antigen receptor signaling...
- Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouseN Ilan
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA
Dev Biol 232:219-32. 2001..We suggest that by serving as a scaffolding, PECAM-1 can bring substrates (STAT5a) and enzymes (a kinase) into close proximity, thereby modulating phosphorylation levels of selected proteins, as previously noted for beta-catenin...
- Identification of the regions of PECAM-1 involved in beta- and gamma-catenin associationsPurba Biswas
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
Biochem Biophys Res Commun 329:1225-33. 2005....
- Molecular characterization of lymphatic endothelial cellsSimona Podgrabinska
Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 99:16069-74. 2002....
- PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stressZsolt Bagi
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Arterioscler Thromb Vasc Biol 25:1590-5. 2005....
- The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivoW A Muller
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
J Leukoc Biol 57:523-8. 1995..Thus, PECAM-1 has a distinct role in the transendothelial migration phase of leukocyte emigration, independent of the adhesion events on the apical surface...
- Molecular characterization and functional analysis of the leukocyte surface protein CD31H Stockinger
Institute of Immunology Vienna International Research Cooperation Center at SFI, University of Vienna
J Immunol 145:3889-97. 1990..We show that signal transduction occurs via formation of a CD31 Ag-mAb-Fc gamma R complex involving either Fc gamma RI (CD64) or Fc gamma RII (CDw32) molecules...
- Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinasesM Y Cao
McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 273:15765-72. 1998....
- Microvessel quantification in primary colorectal carcinoma: an immunohistochemical studyP B Vermeulen
Laboratory of Cancer Research and Clinical Oncology, University of Antwerp, Belgium
Br J Cancer 71:340-3. 1995....
- PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradationPurba Biswas
Department of Pathology, Yale University School of Medicine, 310 Cedar St, Lauder Hall, Rm L115, New Haven, CT 06520, USA
Am J Pathol 169:314-24. 2006....
- Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is localized over the entire plasma membrane of endothelial cellsD Scholz
Max Planck Institute, Department of Experimental Cardiology, Benekestrasse 2, D 61231 Bad Nauheim, Germany
Cell Tissue Res 290:623-31. 1997..In view of these findings, the role of PECAM-1 in the leukocyte migration cascade needs to be re-evaluated...
- Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric studyIlse Van der Auwera
Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
Clin Cancer Res 11:7637-42. 2005..The objective of this study was twofold: (a) to determine which is the most suitable marker of lymph vessels in primary breast tumors and (b) to compare histomorphometric lymph vessel variables in IBC and non-IBC...
- Endothelial cell-cell adhesion and mechanosignal transductionYi Jen Chiu
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Endothelium 11:59-73. 2004..We will also review the available evidence for PECAM-1 as a mechanotransducing molecule in endothelial cells...
- PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cellsGuangju Ji
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Cell Biol 157:173-84. 2002..PECAM-1-dependent H2O2 currents and associated [Ca2+]i transients may play a significant role in regulating neutrophil-endothelial interaction, as well as in oxidant-mediated endothelial response and injury...
- Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissuesMarc P Pusztaszeri
Institute of Pathology, Rue du Bugnon 25 1011, Lausanne, Switzerland
J Histochem Cytochem 54:385-95. 2006..The expression of EC markers CD31, CD34, and vWF in the vascular tree is heterogeneous with a specific pattern for individual vessel types and different anatomic compartments of the same organ. D2-40 labels lymphatic EC only...
- Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1)H C Yan
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
J Biol Chem 270:23672-80. 1995....
- Differential assessment of vascular survival ability and tumor angiogenic activity in colorectal cancerAlexandra Giatromanolaki
Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece
Clin Cancer Res 8:1185-91. 2002..This "vascular survival" potential can be assessed by comparatively examining the vascular density in peripheral and inner tumor areas...
- Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motifDita Gratzinger
Department of Pathology, Yale University School of Medicine, Lauder Hall 115, 310 Cedar St, New Haven, CT 06511, USA
Biochem Biophys Res Commun 301:243-9. 2003....
- Src homology 2 domain-containing protein-tyrosine phosphatases, SHP-1 and SHP-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signalingT L Henshall
Division of Haematology, Hanson Centre for Cancer Research, IMVS, Adelaide, South Australia
J Immunol 166:3098-106. 2001....
- CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylatedJ P Newton
Cell Adhesion Laboratory, Institute of Molecular Medicine, Headington, OX3 9DU, United Kingdom
Biochem Biophys Res Commun 261:283-91. 1999..Chemical cross-linking studies of both soluble and membrane-expressed CD31 confirmed that CD31 exists as a dimer. These studies suggest that, like E-cadherin, PECAM-dimerization is likely to play a role in CD31 adhesion and signaling...
- PECAM-1: old friend, new partnersNeta Ilan
Department of Vascular Biology, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
Curr Opin Cell Biol 15:515-24. 2003....
- Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?Masaki Osawa
Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
J Cell Biol 158:773-85. 2002..Binding of the beads by itself or pulling on the cell surface using poly-l-coated beads did not induce phosphorylation of PECAM-1 and ERK. These results suggest that PECAM-1 is a mechanotransduction molecule...
- Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancerFerenc Renyi-Vamos
Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary
Clin Cancer Res 11:7344-53. 2005..Our aim was to assess the lymphangiogenesis of human NSCLC, and to correlate this with angiogenic phenotype (angiogenic versus nonangiogenic growth pattern) and clinical behavior...
- CD99 plays a major role in the migration of monocytes through endothelial junctionsAlan R Schenkel
Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Nat Immunol 3:143-50. 2002..Therefore, diapedesis, the forward migration of leukocytes through endothelial junctions, is regulated sequentially by two distinct molecules, PECAM-1 and CD99...
- Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migrationGaoyuan Cao
Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
Am J Physiol Cell Physiol 282:C1181-90. 2002....
- PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membraneJohn Dangerfield
Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, United Kingdom
J Exp Med 196:1201-11. 2002....
- Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+ circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activationElisabetta Ferrero
Laboratory of Tumor Immunology, the Human Virology Unit, DIBIT, Italy
Blood 101:186-93. 2003....
- Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injuryJanette Glaser
Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California at Irvine, Irvine, California 92697, USA
J Neurosci Res 77:701-8. 2004..Improved blood flow and oxygen supply to the injury site may contribute to the functional improvement associated with this treatment...
- Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysisBernard Uzzan
Laboratoire de Pharmacologie Hôpital Avicenne, Bobigny, France
Cancer Res 64:2941-55. 2004..MVD was a significant although weak prognostic factor in women with breast cancer. Standardization of MVD assessment is needed...
- Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesisJasenka Mazibrada
Department of Public Health and Microbiology, Medical School of Turin, Turin, Italy
Gynecol Oncol 108:112-20. 2008..The primary aim of this study was to investigate the role of angiogenesis and inflammatory cell response in cervical carcinogenesis...
- A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transductionD K Newton-Nash
Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee 53233, USA
J Immunol 163:682-8. 1999..These data provide evidence that PECAM-1 can dampen signals transduced by ITAM-containing receptors and support inclusion of PECAM-1 within the family of ITIM-containing inhibitors of PTK-dependent signal transduction...
- Short report: codon 125 polymorphism of CD31 and susceptibility to malariaC Casals-Pascual
Nuffield Department of Clinical Laboratory Sciences and National Blood Service, John Radcliffe Hospital, Headington, Oxford, United Kingdom
Am J Trop Med Hyg 65:736-7. 2001....
- Cross-talk between cell adhesion molecules regulates the migration velocity of neutrophilsG E Rainger
Department of Physiology, The Medical School, The University of Birmingham, Birmingham, B15 2TT, UK
Curr Biol 7:316-25. 1997..Signals from chemotactic agents and from the adhesive substrate may regulate these processes, but little is known about their relative importance or their mode of integration...
- Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human plateletsMilenko Cicmil
School of Animal and Microbial Sciences, University of Reading, United Kingdom
Blood 99:137-44. 2002..These data suggest that PECAM-1 may play a role in the regulation of platelet function in vivo...
- Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophilsF Pellegatta
Laboratory of Cardiovascular Pathophysiology, Department of Cardiology, Scientific Institute San Raffaele, Instituto di Ricovero e Cura a Carattere Scientifico, I 20132 Milan, Italy
J Biol Chem 273:27768-71. 1998..In conclusion, PECAM-1/CD31 appears to be one of the molecules functionally coupled to PI3K, suggesting that this enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes...
- Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expressionJ Sun
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
J Biol Chem 271:18561-70. 1996..These data suggest that PECAM-1-ligand interactions can be regulated through multiple pathways including alterations of the cytoplasmic domain and the level of surface expression...
- Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation stateE Pinter
Departments of Pathology and Pediatrics, Yale University, Alexion Pharmaceuticals, Inc, New Haven, Connecticut, USA
Am J Pathol 154:1367-79. 1999....
- Vascular-endothelial-cadherin modulates endothelial monolayer permeabilityP L Hordijk
Dept of Experimental Immunohematology, CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam
J Cell Sci 112:1915-23. 1999..Together, these data show that monolayer permeability and neutrophil transendothelial migration are modulated by VE-cadherin-mediated cell-cell adhesion, which is in turn controlled by the dynamics of the actin cytoskeleton...
- Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markersRahmawati Minhajat
Department of Pathology and Biodefense, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
Virchows Arch 448:127-34. 2006..The present study shows that de novo blood vessels of colon cancer specifically express CD105. These findings provide the basis for novel antiangiogenic cancer therapies...
- Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient miceMichael Carrithers
Department of Neurology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520, USA
Am J Pathol 166:185-96. 2005..These results suggest that CD31 is necessary for maintenance of endothelial integrity and prevention of apoptosis during septic shock and for STAT3-mediated acute phase responses that promote survival during septic shock...
- Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is associated with increased angiogenic potential in non-small-cell lung cancerSebastian Dango
Department of Thoracic Surgery, Albert Ludwigs University Freiburg, 79106 Freiburg, Germany
Lung Cancer 60:426-33. 2008..1-4.0). Here we show for the first time that high CEACAM-1 expression is associated with an increased angiogenic activity in NSCLC, and that the prognostic influence of CEACAM-1 might be derived from this association...
- Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcomeJean Philippe Dales
Service d Anatomie et de Cytologie Pathologiques, Hopital Nord, 13915 Marseille Cedex 20, France
Int J Oncol 24:1197-204. 2004....
- CD31 regulates direction and rate of neutrophil migration over and under endothelial cellsN Thin Luu
Department of Physiology, The Medical School, The University of Birmingham, Birmingham, UK
J Vasc Res 40:467-79. 2003..Thus mechanical and adhesive signals can regulate neutrophil migration driven by locally-acting chemotactic agents...
- Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in ThaisM Kikuchi
Department of Medical Zoology, Saitama Medical School, Moroyrma, Iruma, 350 0495, Saitama, Japan
Parasitol Int 50:235-9. 2001..We found that the frequency of the 125 V/V 563 N/N genotype was significantly high in CM patients as compared with severe cases without CM (P<0.01, OR=2.92), suggesting that this genotype is one of the risk factors for CM...
- PECAM-1 (CD31) expression modulates bleeding time in vivoS Mahooti
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
Am J Pathol 157:75-81. 2000..These studies are consistent with a role for PECAM-1 in modulating thrombosis in the vasculature, which is potentially mediated by endothelial cell PECAM-1 expression...
- Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cellsM Masuda
Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
FEBS Lett 408:331-6. 1997..Our results suggest that PECAM-1 is a component of a mechanosensing machinery acting upstream of SH-PTP2...
- The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)K Sagawa
Receptors and Signal Transduction Section, OIIB, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:31086-91. 1997..Therefore, integrin and immune receptor activation results in tyrosine phosphorylation of PECAM-1 and the binding of the protein-tyrosine phosphatase SHP-2, which could regulate receptor-mediated signaling in cells...
- Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host diseaseE Behar
Department of Pathology, Stanford University, Calif, USA
N Engl J Med 334:286-91. 1996..e., other than HLA) histocompatibility antigens remains a serious problem in recipients of bone marrow transplants. We sought to determine whether the CD31 adhesion molecule is a minor alloantigen...
- Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic ratsStephen J Peterson
Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
J Pharmacol Exp Ther 322:514-20. 2007....
- Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinasesM Cicmil
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, United Kingdom
J Biol Chem 275:27339-47. 2000..The involvement of Src family kinases in this process was confirmed through the study of mouse platelets deficient in Fyn...
- Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivoA A Vaporciyan
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
Science 262:1580-2. 1993..On the basis of these findings in three different models of inflammation, it appears that PECAM-1 is required for neutrophil transmigration in vivo and may thus be a potential therapeutic target...
- Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from SicilyF Listi
Gruppo di Studio sull Immunosenescenza, Dipartiento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
Eur J Immunogenet 31:175-8. 2004..All in all, we believe that the results of the present study would add support to the role of pro/anti-inflammatory genotypes in determining susceptibility or resistance to immune-inflammatory diseases, including atherosclerosis...
- Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouseMariarosaria Galeano
Department of ClinicalExperimental Medicine, Section of Pharmacology, Azienda Ospedaliera Universitaria G Martino, Torre Biologica, 5th Floor, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Diabetes 53:2509-17. 2004..05). Erythropoietin may have a potential application in diabetes-related wound disorders...
- Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functionsG S Duncan
Amgen Institute, Toronto, Ontario, Canada
J Immunol 162:3022-30. 1999..This study provides genetic evidence that CD31 is involved in transbasement membrane migration, but does not play an obligatory role in either vascular development or leukocyte migration...
- Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2Lung Kuo Tai
Cardiovascular Research Institute and Department of Medicine, University of Rochester, New York 14642, USA
J Biol Chem 280:29620-4. 2005..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction...
- The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritisMae Xhum Wong
Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
J Clin Immunol 25:19-28. 2005..Together these observations suggest that PECAM-1 plays a crucial role in the suppression of development of autoimmune arthritis...
- Molecular basis of the effects of shear stress on vascular endothelial cellsYi Shuan J Li
Department of Bioengineering, University of California, San Diego, La Jolla, 92093 0412, USA
J Biomech 38:1949-71. 2005..The knowledge gained on mechano-transduction, with verifications under in vivo conditions, will advance our understanding of the physiological and pathological processes in vascular remodeling and adaptation in health and disease...
- Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31N J Pumphrey
Division of Immunity and Infection, University of Birmingham, UK
FEBS Lett 450:77-83. 1999....
- Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substratesC T Hua
Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000 Australia
J Biol Chem 273:28332-40. 1998....
- High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancerPetri Bono
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Clin Cancer Res 10:7144-9. 2004..LYVE-1, a lymphatic endothelium-specific hyaluronan receptor, is a novel lymphatic vessel marker that is expressed on lymph vessel endothelial cells of both normal and neoplastic tissues...
- Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strainsAlan R Schenkel
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 173:6403-8. 2004..Murine models of inflammatory disease that have been studied using C57BL/6 mice should be re-evaluated using FVB/n or other mouse strains to determine whether PECAM plays a role in those models...
- Improved therapeutic effectiveness by combining recombinant CXC chemokine ligand 10 with Cisplatin in solid tumorsGang Li
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, The People s Republic of China
Clin Cancer Res 11:4217-24. 2005..CXC chemokine ligand 10 (CXCL10) is a potent inhibitor of angiogenesis. We wonder whether the combination of CXCL10 with cisplatin would improve the therapeutic antitumor efficacy...
- PECAM-1 negatively regulates GPIb/V/IX signaling in murine plateletsVipul Rathore
Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
Blood 102:3658-64. 2003....
- Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biologyPeter J Newman
Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, Wis 53201, USA
Arterioscler Thromb Vasc Biol 23:953-64. 2003....
- Minimal regulation of platelet activity by PECAM-1Tarvinder S Dhanjal
Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
Platelets 18:56-67. 2007....
- Nerve growth factor expression and innervation of the painful intervertebral discA J Freemont
Manchester University, UK
J Pathol 197:286-92. 2002..These did not express NGF nor did nerves accompany them. These findings show that nociceptive nerve ingrowth into painful IVD is causally linked with NGF production by blood vessels growing into the IVD, from adjacent vertebral bodies...
- Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytesPedro Viegas
Institut Cochin, Département Biologie Cellulaire, Paris, France
J Cell Sci 119:4634-43. 2006..Our results strongly support the conclusion that PrP(C) is expressed by brain endothelium as a junctional protein that is involved in the trans-endothelial migration of monocytes...
- The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularizationRaquel Lima e Silva
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
FASEB J 21:3219-30. 2007..They provide new targets for therapeutic intervention that may help to bolster and supplement effects obtained with VEGF antagonists...
- Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesisZahra Mamdouh
Department of Pathology and Laboratory Medicine, Weill Medical College, 1300 York Avenue, New York, New York 10021, USA
Nature 421:748-53. 2003..In addition, blockade of TEM with antibodies against PECAM specifically blocks the recruitment of this membrane to the zones of leukocyte migration, without affecting the constitutive membrane trafficking...
- Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactionsK L Jones
Division of Haematology, Hanson Centre for Cancer Research, IMVS, Adelaide, Australia
Blood 98:1456-63. 2001..Collectively, these results indicate that PECAM-1 serves as a physiological negative regulator of platelet-collagen interactions that may function to negatively limit growth of platelet thrombi on collagen surfaces...
- Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activationMae Xhum Wong
Division of Hematology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
J Immunol 168:6455-62. 2002..These results suggest that PECAM-1 acts as a counterregulator in allergic disease susceptibility and severity and negatively modulates mast cell activation...
- Plasticity of human adipose stem cells to perform adipogenic and endothelial differentiationMelanie Wosnitza
Department of Plastic Surgery and Hand Surgery Burn Center, University Hospital of the Aachen University of Technology, Pauwelsstr 30, 52057 Aachen, Germany
Differentiation 75:12-23. 2007..Further, they reveal the plasticity of mature cells of mesenchymal origin to undergo conversion from endothelium to adipose tissue and vice versa...
- Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase C gamma 2 activation by Src family kinasesT Ohmori
Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi 409-3898, Japan
Biochemistry 40:12992-3001. 2001....
- Evaluation of CD31 (PECAM-1) expression using tissue microarray in patients with renal cell carcinomaJohanna Sandlund
Division of Oncology, Department of Radiation Sciences, Umea University, Umea, Sweden
Tumour Biol 28:158-64. 2007..A multivariate analysis of prognostic factors in conventional RCC showed that TNM stage and nuclear grade were independent predictors of prognosis, but CD31 expression did not add further prognostic information...
- CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesionY Tanaka
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
J Exp Med 176:245-53. 1992..We propose that, in collaboration with other receptors/ligands, CD31 functions in an "adhesion cascade" by amplifying integrin-mediated adhesion of CD31+ T cells to other cells, particularly endothelial cells...
- Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studiesF Andreotti
Institute of Cardiology, Catholic University, Rome, Italy
Heart 87:107-12. 2002..Although they are very preliminary and partly conflicting, the data provide some evidence that alterations in the genetics of the inflammatory system may modify the risk of ischaemic heart disease...
- The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signalD E Jackson
Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53233 2121, USA
J Biol Chem 272:6986-93. 1997....
- PECAM-1 and AlveolizationHorace Delisser; Fiscal Year: 2007..unreadable] [unreadable]..
- PECAM-1'S INVOLVEMENT IN ANGIOGENESISHorace Delisser; Fiscal Year: 2002....
- Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancerShaker Mousa; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Biology of the NK cell cytolytic activity rhythmDIPAK KUMAR SARKAR; Fiscal Year: 2010..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
- Mechanisms By Which Endothelium Cells Sense Changes in HemodynamicsBauer Sumpio; Fiscal Year: 2007..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
- Pericytes in Pathogenesis of Germinal-Matrix HemorrhagePraveen Ballabh; Fiscal Year: 2006..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
- Transcription Factor Reporter TechnologyAlexei Bogdanov; Fiscal Year: 2006..abstract_text> ..
- Imaging Alpha (v)beta(3) Integrin ExpressionXiaoyuan Chen; Fiscal Year: 2006..abstract_text> ..
- Molecular Targets in Bronchopulmonary DysplasiaRichard Pierce; Fiscal Year: 2006..These studies will be highly interactive within the Consortium and provide gene expression data for the scientific community at large. ..
- Regulation of Microvascular Development in BPDWilliam Maniscalco; Fiscal Year: 2006..New data from this proposal will be essential for developing novel therapies for BPD. ..
- Thrombostatin-A Thrombin Receptor InhibitorAlvin Schmaier; Fiscal Year: 2006..Second, the preparation of an IND application for its human use for one indication will be achieved. Thrombostatin(tm) has the opportunity to be a first-in-its-class thrombin receptor activation antagonist. [unreadable] [unreadable]..
- Expression Analysis of Prostate CancerPhillip Febbo; Fiscal Year: 2006....
- AUGMENTATION OF ANTIOXIDANT DEFENSES BY IMMUNOTARGETINGVladimir Muzykantov; Fiscal Year: 2007..The overall goal of this proposal is to optimize strategies for vascular AOE targeting, to ultimately initiate translation of this strategy into the clinical domain. ..
- PPARg in trophoblast and placental developmentDAVID MILSTONE; Fiscal Year: 2007..These studies will provide significant new mechanistic information about the role of PPARgamma in placentation, and may suggest future therapeutic possibilities for gestational disease in patients. ..
- Integrating Cell Division and Morphogenesis in Developing VesselsVictoria L Bautch; Fiscal Year: 2010..The results will help us understand how vessels are shaped, which in turn will aid in designing ways to make artificial vessels for therapeutic use. ..
- ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITYDIPAK SARKAR; Fiscal Year: 2009....
- Gap Junction Mediated Signaling and Vascular ResponsesAlexander M Simon; Fiscal Year: 2010..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..
- Viral-Driven Mediators of Chronic Lung Allograft DysfunctionRichard Pierce; Fiscal Year: 2009..This research will study how these viruses cause chronic lung rejection so that treatments for this condition can be developed. (End of Abstract) ..
- Role of the chronic inflammatory mediator NO in early mammary tumorigenesisLESLEY ELLIES; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Combined MRI and Optical Imaging to Improved Breast Cancer DiagnosisMin Ying Su; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Biomarkers for VEGF and mTOR Blockade in Advanced Renal CancerJaime Merchan; Fiscal Year: 2007..This information will be extremely useful for the design of future trials using these agents in renal and other cancers and for future clinical practice. [unreadable] [unreadable] [unreadable]..
- Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1Ugur Ozerdem; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- VEGF and Nitric Oxide in Lung Vascular DevelopmentVivek Balasubramaniam; Fiscal Year: 2007..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
- Cyclic Follicle Function and AngiogenesisRalf Zimmermann; Fiscal Year: 2006..unreadable] [unreadable]..
- CYTOKINE REGULATION OF EARLY EVENTS IN BLOOD VESSEL FORMChristopher Drake; Fiscal Year: 2006..abstract_text> ..
- Molecular Mechanisms of Glucocortoid Resistance: Relevance to Mood DisordersXiaohong Wang; Fiscal Year: 2004..Moreover, insights gained from the proposed research will contribute to the development of novel therapeutic targets for the treatment of mood disorders. ..
- NOVEL TYROSINASE MUTANTS AS IMAGING MARKER GENESAlexei Bogdanov; Fiscal Year: 2002..The long-term goal of this research is to explore and develop novel and useful bifunctional "imaging/therapeutic marker genes" for in vivo use. ..
- VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBCStephen Wagner; Fiscal Year: 2004..abstract_text> ..
- THROMBOPROPHYLAXIS IN THE SURGICAL SETTINGVladimir Muzykantov; Fiscal Year: 2004..The results of this study may provide new means to achieve thromboprophylaxis in surgical settings such as angioplasty and endarterectomy, as well as be a platform for the development of novel forms of antithrombotic therapy. ..
- PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICEAlvin Schmaier; Fiscal Year: 2003..These studies could serve as a basis for the development of a global assay(s) to predict the prothrombotic state in man. (End of Abstract.) ..
- Role of SV40 in Salivary Gland TumorigenesisLESLEY ELLIES; Fiscal Year: 2003..Analysis of molecular changes occurring during salivary gland tumorigenesis may lead to the development of therapeutic agents for the treatment of malignant disease. ..
- ESTROGEN MITOGENIC ACTION IN THE PITUITARYDIPAK SARKAR; Fiscal Year: 2003..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
- OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTIONDIPAK SARKAR; Fiscal Year: 2002....
- CONSTRUCTION OF BIOLOGY RESEARCH FACILITYDIPAK SARKAR; Fiscal Year: 2002..abstract_text> ..
- FN FAK SIGNALING AXIS AND TUMORIGENESISDusko Ilic; Fiscal Year: 2004..abstract_text> ..
- A LONGITUDINAL STUDY IN THE CANINE MODEL OF HUMAN AGINGMin Ying Su; Fiscal Year: 2005..Noninvasive MR imaging techniques may offer a means of detecting early signs of pathological aging, allowing us the opportunity to initiate interventions to slow disease progression. ..
- ADHESION MOLECULES IN NO MODULATED TUMORIGENESISLESLEY ELLIES; Fiscal Year: 2004..These studies will help to define t h e importance of NO mediated alterations in adhesion molecules in tumorigenesis and may lead to improved therapy for cancer patients. ..
- GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITEFredika Robertson; Fiscal Year: 2001..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
- Nanocarriers for delivery of antioxidants to endotheliumVladimir Muzykantov; Fiscal Year: 2004..Completion of these Aims will be a major step towards the long-term goal of our research, which is translation of this promising new technology platform into the clinical domain. ..
- Regulatory elements controlling elastin transcriptionRichard Pierce; Fiscal Year: 2005..These approaches will reveal key mechanisms controlling elastin synthesis and identify targets for strategies to modulate elastin synthesis in the lungs of premature infants and in pulmonary emphysema. ..
- Targeting of Drugs to ICAMVladimir Muzykantov; Fiscal Year: 2005..This study will extend and strengthen the ICAM-directed vascular immunotargeting paradigm that may be used for a prophylaxis and therapies of diverse pulmonary and cardiovascular diseases, in particular, ALl. ..
- PECAM AND CALCIUM SIGNALING AND TRANSMIGRATIONSteven Albelda; Fiscal Year: 2002....
- Ras/Rap Signaling and Endothelial MorphogenesisVictoria Bautch; Fiscal Year: 2009..abstract_text> ..
- Integrating Cell Division and Morphogenesis in VesselsVictoria Bautch; Fiscal Year: 2004..This work should provide a strong framework to begin to understand how cell division and morphogenesis are integrated during blood vessel formation, information critical to reconstituting the process for therapeutic uses. ..
- The Role of PECAM in Models of Lung InjurySteven Albelda; Fiscal Year: 2005..These studies will fill a gap in the basic understanding of lung and cell adhesion biology, as well as provide potentially useful therapeutic information. ..
- Fetal Alcohol Effects on Circadian clocks and POMCDIPAK KUMAR SARKAR; Fiscal Year: 2010..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..
- CYCLOOXYGENASE-2 AND XENOBIOTICS IN VASCULAR INJURYBabette Weksler; Fiscal Year: 2005..abstract_text> ..
- "Vasculata 2007" Conference grant applicationVictoria Bautch; Fiscal Year: 2007..We are particularly interested in reaching out to minority participants and providing them with full scholarships. (End of Abstract) [unreadable] [unreadable] [unreadable]..
- MicroPET and NIR Fluorescence Imaging Tumor AngiogenesisXiaoyuan Chen; Fiscal Year: 2004..All the results obtained here will be used for future application of a R01 type grant. ..
- EMAP II Regulation of Pulmonary Cell ProliferationMARGARET SCHWARZ; Fiscal Year: 2007..abstract_text> ..
- Murine CMV Pneumonitis in Allogeneic BMTOliver Oakley; Fiscal Year: 2005..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
- Vasculature is a determinant of epithelial morphogenesisMARGARET SCHWARZ; Fiscal Year: 2006..Thus, identifying the factors responsible for coordinating vascular formation and distal lung morphogenesis will provide insight into the determinants by which their balance can affect lung development. ..
- Tumor Antigen Discovery in ALL by Expression ProfilingWILLIAM HAINING; Fiscal Year: 2006..This training will form the foundation of my career in translational research. ..
- Molecular Diagnosis of Defective Memory Differentiation in Tumor-Specific T CellsWILLIAM HAINING; Fiscal Year: 2008..This will help identify the molecular basis for defective tumor-specific immunity, and provide a novel assay to predict immune response to cancer immunotherapy. [unreadable] [unreadable] [unreadable]..