cadherins

Summary

Summary: A group of functionally related glycoproteins responsible for the calcium-dependent cell-to-cell adhesion mechanism. They are divided into subclasses E-, P-, and N-cadherins, which are distinct in immunological specificity and tissue distribution. They promote cell adhesion via a homophilic mechanism. These compounds play a role in the construction of tissues and of the whole animal body.

Top Publications

  1. doi The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
  2. doi The ins and outs of the epithelial to mesenchymal transition in health and disease
    M Angela Nieto
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, San Juan de Alicante 03550, Spain
    Annu Rev Cell Dev Biol 27:347-76. 2011
  3. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
  4. ncbi Epithelial-mesenchymal transitions: twist in development and metastasis
    Yibin Kang
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cell 118:277-9. 2004
  5. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
  6. doi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
  7. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
  8. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
  9. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
  10. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001

Detail Information

Publications326 found, 100 shown here

  1. doi The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
    ..Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin. These data suggest that downregulation of the microRNAs may be an important step in tumour progression...
  2. doi The ins and outs of the epithelial to mesenchymal transition in health and disease
    M Angela Nieto
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, San Juan de Alicante 03550, Spain
    Annu Rev Cell Dev Biol 27:347-76. 2011
    ..In addition, the EMT now constitutes a promising target for the treatment of cancer and organ-degenerative diseases...
  3. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
    ..Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers...
  4. ncbi Epithelial-mesenchymal transitions: twist in development and metastasis
    Yibin Kang
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cell 118:277-9. 2004
    ..A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases...
  5. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  6. doi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  7. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
    ..Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion...
  8. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
    Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements...
  9. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  10. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  11. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..Conversely, inhibition of miR-200 reduced E-cadherin expression, increased expression of Vimentin, and induced EMT. Our data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells...
  12. doi EMT, the cytoskeleton, and cancer cell invasion
    Mahmut Yilmaz
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Metastasis Rev 28:15-33. 2009
    ..In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side...
  13. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  14. ncbi Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR 146, CNRS, Institut Curie, Centre Universitaire, Orsay, France
    Oncogene 24:7443-54. 2005
    ..Interactions between PI3K/AKT and other EMT-inducing pathways are presented, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control...
  15. pmc Thinking outside the cell: how cadherins drive adhesion
    Julia Brasch
    Department of Biochemistry and Molecular Biophysics, Columbia University, 1150 Saint Nicholas Avenue, New York, NY 10032, USA
    Trends Cell Biol 22:299-310. 2012
    b>Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold to immunoglobulin domains...
  16. doi Cadherins and neuropsychiatric disorders
    Christoph Redies
    Institute of Anatomy I, Teichgraben 7, Jena University School of Medicine, Jena University Hospital, D 07740 Jena, Germany
    Brain Res 1470:130-44. 2012
    b>Cadherins mediate cell-cell adhesion but are also involved in intracellular signaling pathways associated with neuropsychiatric disease...
  17. pmc Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    Thiruvengadam Arumugam
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 69:5820-8. 2009
    ..012). Therefore, our results suggest that Zeb-1 and other regulators of EMT may maintain drug resistance in human pancreatic cancer cells, and therapeutic strategies to inhibit Zeb-1 and reverse EMT should be evaluated...
  18. pmc Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
    Buzz Baum
    University College London, London WC1E 6BT, England, UK
    J Cell Biol 192:907-17. 2011
    ..This turnover contributes to junction formation and to the maintenance of epithelial integrity during tissue homeostasis and remodeling...
  19. ncbi A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer
    Karsten Gravdal
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 13:7003-11. 2007
    ..We here present novel data, with special focus on the independent relationship between an E-cadherin to N-cadherin switch (EN-switch) and patient prognosis...
  20. doi Epithelial E- and P-cadherins: role and clinical significance in cancer
    Joana Paredes
    University of Porto, Porto, Portugal
    Biochim Biophys Acta 1826:297-311. 2012
    ..In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models...
  21. doi E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  22. doi Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
    ..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis...
  23. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
    ....
  24. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  25. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999
    ..Increased beta-catenin levels may thus promote neoplastic conversion by triggering cyclin D1 gene expression and, consequently, uncontrolled progression into the cell cycle...
  26. ncbi The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
    Victoria Bolós
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    J Cell Sci 116:499-511. 2003
    ....
  27. doi Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila
    Benoit Aigouy
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Cell 142:773-86. 2010
    ..Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape...
  28. doi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
    ..We discuss the possible use of inhibitors of SRC and other kinases, of agents that increase cAMP levels, and of inhibitors of lytic enzymes as pharmacological tools for decreasing endothelial permeability...
  29. ncbi Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
    Nat Rev Cancer 4:118-32. 2004
  30. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  31. doi The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications
    Elisabetta Dejana
    IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy
    Dev Cell 16:209-21. 2009
    ..In this review we discuss recent findings derived from these approaches and their possible integration in a common picture...
  32. ncbi Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
    Jennifer M Halbleib
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:3199-214. 2006
    ..is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo)...
  33. ncbi BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    Michael Zeisberg
    Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 9:964-8. 2003
    ..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease...
  34. doi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
    ..We found that the planar cell polarity cadherins Celsr2 and Celsr3 control these processes...
  35. pmc Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus
    Megan E Williams
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0366, USA
    Neuron 71:640-55. 2011
    ..These observations indicate that cadherin-9 bidirectionally regulates DG-CA3 synapse development and highlight the critical role of differentially expressed molecular cues in establishing specific connections in the mammalian brain...
  36. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
    ..Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis...
  37. pmc E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming
    Torben Redmer
    Max Delbrueck Center, Robert Roessle Strasse 10, 13125 Berlin, Germany Freie Universität Berlin, Department of Biology, Chemistry and Pharmacy, Takustrasse 3, 14195 Berlin, Germany
    EMBO Rep 12:720-6. 2011
    ..Thus, reprogramming requires spatial cues that cross-talk with essential transcription factors. The cell-adhesion molecule E-cadherin has important functions in pluripotency and reprogramming...
  38. pmc Principles of planar polarity in animal development
    Lisa V Goodrich
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 138:1877-92. 2011
    ..Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom...
  39. doi The cell-cell adhesion molecule E-cadherin
    F van Roy
    Department for Molecular Biomedical Research, Molecular Cell Biology Unit, VIB, Technologiepark 927, 9052 Ghent, Belgium
    Cell Mol Life Sci 65:3756-88. 2008
    ....
  40. ncbi Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    T Usui
    Department of Biophysics, Faculty of Science, Japan
    Cell 98:585-95. 1999
    ..These results, together with phenotypes caused by ectopic expression of fz and fmi, suggest that cells acquire the P-D polarity by way of the Fz-dependent boundary localization of Fmi...
  41. ncbi The SLUG zinc-finger protein represses E-cadherin in breast cancer
    Karen M Hajra
    Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:1613-8. 2002
    ..Taken together, the data indicate the E-box elements in the proximal E-cadherin promoter are critical in transcriptional repression of the E-cadherin gene, and SLUG is a likely in vivo repressor of E-cadherin in breast cancer...
  42. ncbi Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    Binhua P Zhou
    Department of Molecular and Cellular Oncology, Breast Cancer Basic Research Program, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Cell Biol 6:931-40. 2004
    ..Furthermore, inhibition of GSK-3beta results in the upregulation of Snail and downregulation of E-cadherin in vivo. Thus, Snail and GSK-3beta together function as a molecular switch for many signalling pathways that lead to EMT...
  43. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  44. ncbi Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
    Yasuyuki Fujita
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Nat Cell Biol 4:222-31. 2002
    ..Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis...
  45. pmc TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    Hidenori Kasai
    Teijin Biomedical Laboratory, Medical Research Council Technology, 1 3 Burtonhole Lane, London, NW7 1AD, UK
    Respir Res 6:56. 2005
    ..We examined whether the potent fibrogenic cytokine TGF-beta1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-beta1-mediated EMT...
  46. pmc Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
    J G Herman
    Oncology Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 93:9821-6. 1996
    ....
  47. pmc p120-catenin binding masks an endocytic signal conserved in classical cadherins
    Benjamin A Nanes
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 199:365-80. 2012
    p120-catenin (p120) binds to the cytoplasmic tails of classical cadherins and inhibits cadherin endocytosis...
  48. pmc Reggies/flotillins regulate E-cadherin-mediated cell contact formation by affecting EGFR trafficking
    Gonzalo P Solis
    Department of Biology, University of Konstanz, 78467 Konstanz, Germany
    Mol Biol Cell 23:1812-25. 2012
    ..Thus, by promoting EGFR internalization, reggies restrict the EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate AJ formation and dynamics and thereby cell adhesion...
  49. pmc The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    E A Carver
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mol Cell Biol 21:8184-8. 2001
    ....
  50. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    ..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
  51. doi Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
    David J McConkey
    Department of Urology, U T M D Anderson Cancer Center, P O Box 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Metastasis Rev 28:335-44. 2009
    ..The results suggest that EMT coordinately regulates drug resistance and muscle invasion/metastasis in urothelial cancer and is a dominant feature of overall cancer biology...
  52. ncbi Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
    Robert L Yauch
    Department of Molecular Diagnostics, Genentech, Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 11:8686-98. 2005
    ..These data support a potential role for EMT as a determinant of EGFR activity in NSCLC tumor cells and E-cadherin expression as a novel biomarker predicting clinical activity of the EGFR inhibitor erlotinib in NSCLC patients...
  53. doi Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 13:529-40. 2011
    ..Finally, we provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin...
  54. doi Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion
    Noboru Ishiyama
    Division of Signaling Biology, Ontario Cancer Institute, ON, Canada
    Cell 141:117-28. 2010
    ..Single-residue mutations within the JMD(core)-binding site of p120 abolished its interaction with E- and N-cadherins in vitro and in cultured cells...
  55. ncbi VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892 4340, USA
    Nat Cell Biol 8:1223-34. 2006
    ....
  56. pmc The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Biol Chem 283:14910-4. 2008
    ..These results suggested that loss of expression of the miR-200 family members may play a critical role in the repression of E-cadherin by ZEB1 and ZEB2 during EMT, thereby enhancing migration and invasion during cancer progression...
  57. pmc Involvement of members of the cadherin superfamily in cancer
    Geert Berx
    Molecular and Cellular Oncology Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Cold Spring Harb Perspect Biol 1:a003129. 2009
    We review the role of cadherins and cadherin-related proteins in human cancer. Cellular and animal models for human cancer are also dealt with whenever appropriate...
  58. pmc Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
    Andrea Hartsock
    Departments of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5430, USA
    Biochim Biophys Acta 1778:660-9. 2008
    ....
  59. pmc Intercellular junction assembly, dynamics, and homeostasis
    Kathleen J Green
    Northwestern University Feinberg School of Medicine, Department of Pathology, R H Lurie Comprehensive Cancer Center, 303 E Chicago Ave Chicago, Illinois 60611, USA
    Cold Spring Harb Perspect Biol 2:a000125. 2010
    ..We will explore signaling and trafficking machineries that drive assembly and remodeling and how these mechanisms are co-opted in human disease...
  60. pmc Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling
    Julian Heuberger
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Cold Spring Harb Perspect Biol 2:a002915. 2010
    ..These factors provide a mechanism whereby cadherin loss and increased Wnt signaling induce epithelial-mesenchymal transition in both carcinomas and development...
  61. pmc Snail family regulation and epithelial mesenchymal transitions in breast cancer progression
    Antonio Garcia De Herreros
    IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, C Doctor Aiguader, 88, 08003 Barcelona, Spain
    J Mammary Gland Biol Neoplasia 15:135-47. 2010
    ..We also analyze the contribution of EMT and Snail genes in the process of tumorigenesis using the mammary gland as cellular model...
  62. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    ..expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell-cell adhesion...
  63. pmc Mechanical tugging force regulates the size of cell-cell junctions
    Zhijun Liu
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:9944-9. 2010
    ....
  64. ncbi The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    E Batlle
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Nat Cell Biol 2:84-9. 2000
    ..Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the E-cadherin gene...
  65. pmc miR-200 enhances mouse breast cancer cell colonization to form distant metastases
    Derek M Dykxhoorn
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7181. 2009
    ..Because some miRNAs are dysregulated in cancer and affect cellular transformation, tumor formation, and metastasis, we examined whether changes in miRNA expression might explain the differences in metastasis of these cells...
  66. pmc Evolution: structural and functional diversity of cadherin at the adherens junction
    Hiroki Oda
    JT Biohistory Research Hall, Takatsuki, Osaka 569 1125, Japan
    J Cell Biol 193:1137-46. 2011
    ..A key component of AJs is classical cadherins, a group of transmembrane proteins that maintain dynamic cell-cell associations in many animal species...
  67. ncbi VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Röntgenstr 20, D 48149 Munster, Germany
    Arterioscler Thromb Vasc Biol 28:223-32. 2008
    ..This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes...
  68. pmc E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch
    Nicolas Borghi
    Departments of Biology, Mechanical Engineering, Chemical Engineering, Structural Biology, and Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:12568-73. 2012
    Classical cadherins are transmembrane proteins at the core of intercellular adhesion complexes in cohesive metazoan tissues...
  69. pmc VE-cadherin: at the front, center, and sides of endothelial cell organization and function
    Elizabeth S Harris
    Department of Biology, The James H Clark Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    Curr Opin Cell Biol 22:651-8. 2010
    ..Here we highlight recent work that has advanced our understanding of multiple regulatory and signaling mechanisms that converge on VE-cadherin and have consequences for endothelial barrier function and angiogenic remodeling...
  70. doi Cadherin-catenin adhesion complexes at the synapse
    G Stefano Brigidi
    Department of Cellular and Physiological Sciences and the Brain Research Centre, University of British Columbia, Canada
    Curr Opin Neurobiol 21:208-14. 2011
    Classic cadherins function as key organizers during the formation and remodeling of synapses in the vertebrate central nervous system...
  71. pmc Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
    Mol Cell Biol 24:306-19. 2004
    ..Our results establish a direct causal relationship between Snail-dependent repression of E-cadherin and the modification of chromatin at its promoter...
  72. pmc Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
    Yue Xu
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:8129-34. 2010
    ..Our data suggest that differential usage of cell adhesion systems by ESCs to maintain self-renewal may explain their profound differences in terms of morphology, growth factor requirement, and sensitivity to enzymatic cell dissociation...
  73. pmc Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    J Yang
    Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1465-75. 2001
    ....
  74. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
    ..Finally, the functional relevance of this regulation was verified by quantitative real-time PCR and immunohistochemistry on a cohort of breast cancer samples...
  75. pmc Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells
    Kanyan Xiao
    Department of Dermatology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Biol 163:535-45. 2003
    ..These results demonstrate that cellular levels of p120ctn function as a set point mechanism that regulates cadherin expression levels, and that a major function of p120ctn is to control cadherin internalization and degradation...
  76. ncbi Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D
    H Bolz
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Nat Genet 27:108-12. 2001
    ..In an accompanying paper, it is shown that mutations in the mouse ortholog cause disorganization of inner ear stereocilia and deafness in the waltzer mouse...
  77. ncbi Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
    Sivan Elloul
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Cancer 103:1631-43. 2005
    ..For the current study, the authors analyzed the relation between the expression of Snail, Slug, and Sip1; the expression of MMP-2 and E-cadherin; and clinical parameters in patients with metastatic ovarian and breast carcinoma...
  78. ncbi Extending the host range of Listeria monocytogenes by rational protein design
    Thomas Wollert
    Molecular Host Pathogen Interactions, Division of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Cell 129:891-902. 2007
    ..By rationally adapting a single protein, we thus create a versatile murine model of human listeriosis...
  79. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus...
  80. pmc Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner
    Quint le Duc
    Hubrecht Institute, University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands
    J Cell Biol 189:1107-15. 2010
    ..By analogy, cadherin complexes may function as mechanosensors at cell-cell junctions, but this capacity of cadherins has not been directly demonstrated...
  81. doi Cadherin switching
    Margaret J Wheelock
    University of Nebraska Medical Center, Department of Oral Biology and Eppley Cancer Center, Omaha, NE 68198 7696, USA
    J Cell Sci 121:727-35. 2008
    ..In addition, p120-catenin probably plays multiple roles in cadherin switching, regulating Rho GTPases and stabilizing cadherins.
  82. ncbi N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation
    James Hulit
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Res 67:3106-16. 2007
    ..Thus, de novo expression of N-cadherin in mammary ducts enhances metastasis of breast tumors via enhanced ERK signaling...
  83. pmc p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin
    Kanyan Xiao
    Department of Dermatology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:5141-51. 2005
    ..VE-cadherin expression levels are regulated by p120 catenin, which prevents lysosomal degradation of cadherins by unknown mechanisms...
  84. pmc Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    Dimitrios Iliopoulos
    Department Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 39:761-72. 2010
    ..The interaction between miR-200 and Suz12 is highly conserved, suggesting that it represents an ancient regulatory mechanism to control the growth and function of stem cells...
  85. doi Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly
    S Lawrence Zipursky
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, 90095, USA
    Cell 143:343-53. 2010
    ..Although these properties suggest that Dscams and Pcdhs could act as specificity molecules, they may do so in ways that challenge traditional views of how neural circuits assemble...
  86. pmc Identifying autism loci and genes by tracing recent shared ancestry
    Eric M Morrow
    Division of Genetics, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Science 321:218-23. 2008
    ....
  87. ncbi Molecular requirements for epithelial-mesenchymal transition during tumor progression
    Margit A Huber
    Department of Dermatology, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Opin Cell Biol 17:548-58. 2005
    ..Increasing evidence suggests that EMT plays a specific role in the migration of cells from a primary tumor into the circulation and may provide a rationale for developing more effective cancer therapies...
  88. ncbi Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
    Masato Maeda
    Department of Oral Biology College of Dentistry, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Cell Sci 118:873-87. 2005
    ..Together, these data suggest that cadherin switching is necessary for increased motility but is not required for the morphological changes that accompany EMT...
  89. pmc MicroRNA-373 induces expression of genes with complementary promoter sequences
    Robert F Place
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 105:1608-13. 2008
    ..In conclusion, we have identified a miRNA that targets promoter sequences and induces gene expression. These findings reveal a new mode by which miRNAs may regulate gene expression...
  90. ncbi The cadherin superfamily: diversity in form and function
    B D Angst
    Division of Membrane Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Cell Sci 114:629-41. 2001
    Over recent years cadherins have emerged as a growing superfamily of molecules, and a complex picture of their structure and their biological functions is becoming apparent...
  91. ncbi Ovarian cancer metastasis: integrating insights from disparate model organisms
    Honami Naora
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Rev Cancer 5:355-66. 2005
    ..Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets...
  92. pmc Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
    Stephan Huveneers
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, 3584 CT, Utrecht, Netherlands
    J Cell Biol 196:641-52. 2012
    ..These findings implicate Vinculin-dependent cadherin mechanosensing in endothelial processes such as leukocyte extravasation and angiogenesis...
  93. pmc Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells
    Quynh T Phan
    Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Biol 5:e64. 2007
    ..Therefore, Als3 is a fungal invasin that mimics host cell cadherins and induces endocytosis by binding to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells...
  94. pmc The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    K Aigner
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Vienna, Austria
    Oncogene 26:6979-88. 2007
    ..In invasive ductal and lobular breast cancer, upregulation of ZEB1 was stringently coupled to cancer cell dedifferentiation. Our data show that ZEB1 represents a key player in pathologic EMTs associated with tumour progression...
  95. doi E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation
    Taotao Chen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Stem Cells 28:1315-25. 2010
    ..Our results highlight the critical role of E-cadherin-mediated cell-cell contact in reprogramming and suggest new routes for more efficient iPS cell generation...
  96. ncbi N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish
    Elim Hong
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Development 133:3895-905. 2006
    ..studies uncover key cellular mechanisms underlying neural tube morphogenesis in teleosts, and reveal a role for cadherins in promoting the polarized cell behaviors that underlie cellular rearrangements and shape the vertebrate embryo.
  97. doi Cadherins and epithelial-to-mesenchymal transition
    Alexander Gheldof
    Department for Molecular Biomedical Research, Unit of Molecular and Cellular Oncology, VIB, Ghent, Belgium
    Prog Mol Biol Transl Sci 116:317-36. 2013
    ..This is also reflected at the level of the cadherins, where the cadherin switch between E- and N-cadherins is a classical example seen in cancer-related EMT...
  98. pmc Repression of E-cadherin by the polycomb group protein EZH2 in cancer
    Q Cao
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Oncogene 27:7274-84. 2008
    ..Taken together, these observations provide a novel mechanism of E-cadherin regulation and establish a functional link between dysregulation of EZH2 and repression of E-cadherin during cancer progression...
  99. doi Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    Muh Hwa Yang
    Institutes of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hepatology 50:1464-74. 2009
    ..Twist and Snail were independently regulated, but exerted an additive inhibitory effect to suppress E-cadherin transcription...
  100. pmc Bacillus thuringiensis: A story of a successful bioinsecticide
    Alejandra Bravo
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Insect Biochem Mol Biol 41:423-31. 2011
    ..Also, recent data on insect responses to Cry toxin attack is discussed. Finally, we review the different Bt based products, including transgenic crops, that are currently used in agriculture...
  101. doi Planar polarized actomyosin contractile flows control epithelial junction remodelling
    Matteo Rauzi
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Nature 468:1110-4. 2010
    ..Thus, epithelial morphogenesis is not properly reflected by Myosin II steady state distribution but by polarized contractile actomyosin flows that emerge from interactions between E-cadherin and actomyosin networks...

Research Grants71

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..Molecules, including nectins and cadherins, which regulate cell-cell interactions will be investigated as cells transition from a migratory to a sessile ..
  2. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..implicated in AMPAR depression and spine shrinkage in LTD disrupt AKAP79/150 interactions with actin, MAGUKs and cadherins and lead to loss of the AKAP and anchored PKA from synapses...
  3. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    ....
  4. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..Extensive examination of the mechanisms and potential therapeutic targets will advance the understanding and potential cure for AKI in proximal tubular regeneration. ..
  5. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..This may lead to future discovery of a new therapeutic intervention for cardiovascular and cerebrovascular diseases. ..
  6. Mechanisms of Pleural Fibrosis in Empyema
    Kamal A Mohammed; Fiscal Year: 2013
    ..Currently there are no effective treatments for pleural fibrosis therefore the findings from these studies will move towards development of potential therapeutics against empyema and help to better manage empyema patients. ..
  7. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..By inhibiting endocytic recycling, anthrax toxins also reduce levels of cell adhesion molecules (e.g., cadherins) and signaling proteins (e.g...
  8. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013
    ....
  9. FUNCTION OF THE RAS RELATED RAL PROTEINS
    LARRY FEIG; Fiscal Year: 2009
    ..It will also test whether knockdown of other components of the Ral signaling cascade in fibroblasts also blocks tumor progression, and whether these effects can be recapitulated in mice...
  10. Function of the Ras Related Ral Protein
    LARRY FEIG; Fiscal Year: 2013
    ..It is anticipated that new strategies to block tumor development by targeting the Ral GTPase signaling cascade in epithelial cells and/or stromal fibroblasts will emerge from the result of experiments described in this proposal. ..
  11. Alcohol and Breast Cancer
    Jia Luo; Fiscal Year: 2012
    ..Understanding the interactions among alcohol, ErbB2 and MUC1 will also provide an important insight into the pathogenesis of some human diseases related to alcohol abuse as well as alcohol's teratogenic effect during development. ..
  12. Calcium-sensing Receptor and Keratinocyte Differentiation
    Chia Ling Tu; Fiscal Year: 2013
    ..Successful completion of this project will greatly advance our knowledge of skin cell differentiation and help understanding the pathogenesis of various skin disorders manifesting abnormal differentiation. ..
  13. Molecular genetics of epithelium formation in C. elegans
    Stephen E Von Stetina; Fiscal Year: 2010
    ..Positive candidates will be analyzed in detail to discover their role in establishing polarity. These results will add to our knowledge of this basic cell biological process and may identify therapeutic targets for human disease. ..
  14. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2012
    ....
  15. Network modeling of epithelial mesenchymal transition in liver cancer metastasis
    Steven N Steinway; Fiscal Year: 2013
    ..We expect that the proposed model will produce novel critical targets for potential prevention and/or treatment of metastatic HCC. ..
  16. Sphingosine 1-Phosphate: A New Target for Early Diabetic Retinopathy
    Arup Das; Fiscal Year: 2013
    ....
  17. MOLECULAR BASIS OF INHERITED DEAFNESS
    David P Corey; Fiscal Year: 2013
    ..While the homomeric binding of classical cadherins is understood, these tip-link cadherins lack the key amino acids that mediate such binding...
  18. Membrane skeleton regulation of cell shape and interactions in lens development
    Velia M Fowler; Fiscal Year: 2013
    ..Mathias). These studies will establish basic mechanisms for gap junction control of lens transparency, and provide new insights for therapies in cataract prevention. ..
  19. Regulation of Genomic Instability in Early Breast Cancer
    Thea D Tlsty; Fiscal Year: 2013
    ..abstract_text> ..
  20. Biology of desmosome-gap junctions in the testis
    Dolores D Mruk; Fiscal Year: 2010
    ..Finally, the function of gap junctions will be assessed in functional experiments when two key desmosomal cadherins, namely desmoglein-2 and desmocollin-2, are silenced in Sertoli cells in vitro by RNAi. Second, the P.I...
  21. Polarization and directed cell movements in engineered cellular environments
    Deborah E Leckband; Fiscal Year: 2010
    ..Leckband and Wang are collaborating on an independent project involving cadherins and stem cell differentiation...
  22. Identification of Mechanically Sensitive Proteins in Early Development
    Douglas W DeSimone; Fiscal Year: 2013
    ..by which cells sense local stresses, which typically are transduced through adhesive specializations involving cadherins, integrins and the cytoskeleton...
  23. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ....
  24. Cadherin-catenin Mediated Contact Inhibition of Cell Growth
    Barry M Gumbiner; Fiscal Year: 2013
    ..Findings from these studies should reveal how contact inhibition regulates normal tissue development and how the loss of contact inhibition leads to the formation and progression of tumors. ..
  25. Role of Reishi on cell surface proteins and signaling modulation in IBC
    IVETTE SUAREZ; Fiscal Year: 2013
    ....
  26. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..We propose to study a new paradigm that explains how Listeria monocytogenes, and perhaps also other invasive enteropathogens, breach the intestinal barrier. ..
  27. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..abstract_text> ..
  28. Mechanism/Regulation of Intestinal Thiamin Uptake
    Hamid M Said; Fiscal Year: 2013
    ..abstract_text> ..
  29. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Ig) domain containing intercellular cell adhesion molecules (ICAMs) and synaptic CAMs (synCAMs), as well as the cadherins. We will also focus on integrins that mediate microglial activation in other disease models, such as LFA-1 and ..
  30. Cadherin-11 growth factor receptor interactions in RA fibroblast hyperplasia
    ERIKA HEIDI NOSS; Fiscal Year: 2013
    ..Since interactions between cadherins and RTKs like PDGFRs influence cell proliferation and differentiation in tumor and other tissue models, the ..
  31. Epigenetic regulation of lens fiber cell differentiation: The role of DNA methyla
    Michael L Robinson; Fiscal Year: 2013
    ..We will use histological, immunological and high throughput next generation sequencing strategies to comprehensively investigate how DNA methylation influences lens fiber cell differentiation. ..
  32. Candida albicans Epithelial Cell Interactions and Oropharyngeal Disease
    Scott G Filler; Fiscal Year: 2013
    ..albicans Cht2 and Hgt12 govern epithelial cell invasion, damage, and virulence;and 3) use overexpression-rescue and null mutant analysis to identify additional target genes of Tpk2 that mediate epithelial cell invasion and damage. ..
  33. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2012
    ..Microtubules are critical to many cellular functions and have been a target of chemotherapeutic agents in cancer therapy. ..
  34. The role of MID1/MID2 in regulating epithelial adhesion
    CATHERINE KOTO; Fiscal Year: 2013
    ....
  35. Proteolysis of cadherins in cranial neural crest
    ANDREW THOMAS SCHIFFMACHER; Fiscal Year: 2013
    ..In the long term, our results will facilitate the development of novel screening, diagnosis, and treatment modalities and/or illuminate new therapeutic targets to combat aberrant EMT-associated human diseases, syndromes and cancers. ..
  36. MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSION
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2011
    ..This proposal will investigate how fibroids are developed and grow, and ways to prevent them, including their symptoms. ..
  37. CHEMOPREVENTION WITH GREEN TEA POLYPHENON E (PPE) AND EGFR-TKIs IN HEAD AND NECK
    DONG MOON SHIN; Fiscal Year: 2011
    ..This may be further enhanced by the identification of tumor markers that can serve as indicators for treatment efficacy. ..
  38. Targeting Cathepsin L: A Novel Strategy to Impede Prostate and Breast Cancer Meta
    Dietmar W Siemann; Fiscal Year: 2013
    ....
  39. Regulation Of Cortical Neurogenesis By Apical Complex Proteins
    Seonhee Kim; Fiscal Year: 2013
    ..regulating the formation of adhesive cell-cell junction by the assembly of the apical complex, and targeting of cadherins to AJ and the lateral cell junction...
  40. Targeting EWS/FLI1-driven pathways to improve therapeutic gains in Ewing's Sarcom
    Vicente Notario; Fiscal Year: 2012
    ..abstract_text> ..
  41. The role of WNT10B and HMGA2 in Lung Metastasis in Triple Negative Breast Cancer
    GUSTAVO ADOLFO MIRANDA-CARBONI; Fiscal Year: 2013
    ..Our findings may alter therapeutics for the metastatic TNBC tumors. ..
  42. Role of CCN6 (WISP3) in the progression and metastasis of breast cancer
    Celina G Kleer; Fiscal Year: 2012
    ..These studies may form the basis of intervention and therapy in breast cancer, potentially preventing premalignant lesions from becoming malignant and metastasizing. ..
  43. The Role of miRNAs in Epithelial-Mesenchymal Transition and Metastasis
    Yibin Kang; Fiscal Year: 2013
    ....
  44. Effect of Hyperglycemia on Embryonic Heart Development
    Devon Scott; Fiscal Year: 2012
    ..Research needs to be conducted on the effect of glucose on the development of cardiac malformations. ..
  45. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ....
  46. Lysyl Oxidase Propeptide: Breast Cancer Inhibitor
    Gail E Sonenshein; Fiscal Year: 2013
    ....
  47. Directed Self Assembly of Complex Branching Micro-Tissues
    JEFFREY R contact MORGAN; Fiscal Year: 2010
    ..e., cadherins and integrins) and cytoskeletal proteins (i.e...
  48. Corneal endothelial cell survival in human donor corneas for transplantation
    Shay Whey M Koh; Fiscal Year: 2012
    ..Intra-operative VIP (or CNTF) treatment decreases CE damage in an established in vitro endothelial keratoplasty model. ..
  49. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2013
    ..This work will provide a comprehensive understanding of how Pdcd4 modulates colon tumor progression and holds great promise for novel interventions for preventing and treating colon cancer. ..
  50. Regulation of call adhesion in Xenopus
    KEN CHO; Fiscal Year: 2009
    ..Cell adhesion molecules such as cadherins, protocadherins and integrins have been implicated in the differential regulation of cell adhesion and cell ..
  51. Function of Desmoglein 1/Pemphigus Foliaceus Antigen
    KATHLEEN JANEE GREEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The desmosomal cadherins are cell-cell adhesion molecules that are essential for epidermal integrity...
  52. ERalpha Regulation of Intestinal Homeostasis & Tumorigenesis
    Karen A Gould; Fiscal Year: 2010
    ....
  53. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2013
    ....
  54. The Role of Sirt1 in Prostate Cancer Cell Adhesion and Progression
    Yan Dai; Fiscal Year: 2010
    ..The establishment of the Sirt1 function as a metastasis inducer and understanding of how it regulates tumor cell migration, should lead to new target of treatment modality and molecular targeting for prostate cancer therapy. ..
  55. Molecular Regulation of Cancer Progression
    Alan Wells; Fiscal Year: 2013
    ..Lastly, in the longer term, select molecular fingerprints or signaling cascades could be developed as targets for future agents. ..
  56. Signals Regulating SAG Development
    James A Marrs; Fiscal Year: 2010
    ..Aim 1: Determine the expression pattern for cadherin-2, -4, -6 and -10 (cadherins expressed in the SAG) during normal and knockdown embryo SAG development...
  57. Phosphoinsitide signaling in Breast Epithelial Morphogenesis and Metastasis
    Kun Ling; Fiscal Year: 2013
    ....
  58. The Role of Afadin in Coordinating Cell Adhesion Molecules during Synaptogenesis
    GERARD MJ BEAUDOIN; Fiscal Year: 2010
    ..Junctions analogous to adherens junctions are formed during synaptogenesis. Cadherins are intercellular adhesion molecules central to the formation of adherens junctions in epithelial cells...
  59. PI Signaling Role in Epithelial/Mesenchymal Transition
    Richard A Anderson; Fiscal Year: 2013
    ..focused aims will assess this hypothesis (1) We will investigate the role of PIPKI? in the endocytosis of cadherins. The focus will be on the basal and growth factor stimulated E-cadherin endocytosis regulated by PIPKI?...
  60. Role of p120-catenin in oral squamous cell carcinoma
    Zhongjian Xie; Fiscal Year: 2010
    ..Understanding this mechanism will bring the possibility of new preventive and therapeutic options for OSCC. ..
  61. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2012
    ..cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to intermediate filaments...
  62. ORIGIN AND MAINTENANCE OF THE OCULAR SURFACE EPITHELIA
    DAVID CY BEEBE; Fiscal Year: 2013
    ..Information derived from both aims will be valuable for the replacement of injured or defective corneal and conjunctival epithelia using induced pluripotent cells or by "reprogramming" of other epithelial cell types. ..
  63. DNA methylation in aging, race and prostate cancer
    Rajvir Dahiya; Fiscal Year: 2006
    ..This information can be used for better management of prostate cancer using DNA methylated genes as diagnostic or prognostic biomarkers. ..
  64. METAL INDUCED INJURY IN HEPATOCYTES
    Harriet Isom; Fiscal Year: 2006
    ..abstract_text> ..
  65. ADHESION MOLECULES AND EPIDERMAL STRATIFICATION
    ROBERT LAVKER; Fiscal Year: 2001
    ..b>Cadherins are constituents of both desmosomes and adherens junctions...
  66. CELL ADHESION INDUCED DIFFERENTIATION IN EYE TISSUE
    JAMES MARRS; Fiscal Year: 2000
    ..b>Cadherins are calcium dependent cell-cell adhesion molecules that are essential for mammalian development...
  67. HORMONE REGULATED INVOLUTION SIGNALED THROUGH E CADHERIN
    Mark Day; Fiscal Year: 2003
    ..abstract_text> ..
  68. Determinants of Phenotype in Retinal Pigment Epithelium
    Janice Burke; Fiscal Year: 2007
    ..known to be important epithelial morphoregulators, and RPE cells are unusual in that they express at least two cadherins, N-cadherin and E-cadherin, which are not normally found in the same epithelial cells...
  69. Coordinating Adhesion Receptors in Axon Growth
    Jack Lilien; Fiscal Year: 2006
    ..accomplished by deletion and mutagenesis of N-cadherin, as well as functional comparison of other Type I and II cadherins present in the neural retina for the ability to participate in cross-regulation between cadherin and integrin...
  70. The role of E-cadherin in photocarcinogenesis
    Sabine M Brouxhon; Fiscal Year: 2010
    ..Moreover, in depth knowledge of how specific degradative pathways, via PGE2-EP2 signaling, contribute to UV-induced E-cadherin downregulation might yield new targets for validation in cancer diagnosis and therapy. ..
  71. Modulation of the Intercellular Junction Cadherins
    Teruna Siahaan; Fiscal Year: 2001
    ..Tight intercellular junctions are mediated, at least in part, by cell surface proteins called E-cadherins. Cadherin- mediated cell-cell adhesion is produced by homophilic interactions in which E-cadherin molecules from ..