Genomes and Genes
Summary: Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Publications226 found, 100 shown here
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesS Sakaguchi
Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
J Immunol 155:1151-64. 1995..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
- Regulatory T cells in transplantation toleranceKathryn J Wood
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Nat Rev Immunol 3:199-210. 2003....
- Human neutrophil alloantigensJ Bux
Blood Service West of the German Red Cross, Feithstrasse 182, 58097 Hagen, Germany
Vox Sang 94:277-85. 2008..This review describes alloantigens currently listed in the human neutrophil alloantigen (HNA) system...
- Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipientsNicole A Mifsud
Department of Medicine, Monash University, Central Clinical School, The Alfred Hospital, Melbourne, Victoria, Australia
Transplantation 90:1439-49. 2010....
- Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of functionM K Levings
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
J Exp Med 193:1295-302. 2001....
- Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survivalTimucin Taner
Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, PA, USA
Am J Transplant 5:228-36. 2005..These therapeutic effects, achieved by targeting both major pathways of allorecognition, provide the basis for a clinically applicable strategy to suppress graft rejection...
- Allorecognition and the alloresponse: clinical implicationsB Afzali
Department of Nephrology and Transplantation, King s College London, Guy s Hospital Campus, London, UK
Tissue Antigens 69:545-56. 2007..As the understanding of these processes improves, the ability to generate clinically viable immunotherapies will increase...
- The frequencies of human neutrophil alloantigens in the Chinese Han population of GuangzhouWenjie Xia
Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, Guangdong, China
Transfusion 51:1271-7. 2011..This study aimed to determine the frequencies of HNAs in the major Han ethnic group living in Guangdong Province, Southern China...
- Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2E Moritz
Discipline of Hematology and Hemotherapy, Federal University of Sao Paulo, Sao Paulo, Brazil
Vox Sang 98:160-6. 2010....
- Specificity of T-cell alloreactivityNathan J Felix
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nat Rev Immunol 7:942-53. 2007....
- Pathways of major histocompatibility complex allorecognitionBehdad Afzali
Department of Nephrology and Transplantation, Guy s Hospital, Kings College London, London, UK
Curr Opin Organ Transplant 13:438-44. 2008..Here, we review the pathways of allorecognition and their potential relevance to the balance between regulatory and effector responses following transplantation...
- Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matingsLi Ping Jin
Laboratory for Reproductive Immunology, Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, China
J Immunol 173:3612-9. 2004..This procedure might be considered potentially useful for fetal survival when used as an immunotherapy for human recurrent spontaneous abortion...
- Monitoring of indirect allorecognition: wishful thinking or solid data?M M Waanders
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Tissue Antigens 71:1-15. 2008....
- Abrogation of antibody-mediated allograft rejection by regulatory CD4 T cells with indirect allospecificityChris J Callaghan
University Department of Surgery, Addenbrooke s Hospital, Cambridge, United Kingdom
J Immunol 178:2221-8. 2007..Their development is associated with intrinsic tolerance within the alloantigen-specific B cell compartment that persists after T cell help is made available...
- Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymisJayasimha Rao
Department of Cell Biology and the Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia 22908, USA
Biol Reprod 68:290-301. 2003..The presence of a defensin-like motif suggests that E-3 may play a role in protecting the sperm from microbial infections in the epididymis and in the female reproductive tract...
- Gene frequencies of the HNA-4a and -5a neutrophil antigens in Brazilian persons and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-5a genotypingJosé Daniel Braz Cardone
Discipline of Hematology and Hemotherapy, Federal University of Sao Paulo, Sao Paulo, Brazil
Transfusion 46:1515-20. 2006..HNA-4a has been linked to alloimmune neonatal neutropenia, but the HNA-5a clinical significance is unclear...
- The importance of the indirect pathway of allorecognition in clinical transplantationM Refik Gökmen
Immunoregulation Laboratory, King s College London, 5th Floor, Southwark Wing, Guy s Hospital, Great Maze Pond, London SE1 9RT, United Kingdom
Curr Opin Immunol 20:568-74. 2008..An improved understanding of the indirect pathway is likely to bring important benefits to transplant recipients...
- Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificityM A Brehm
Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA
Am J Transplant 10:1738-48. 2010..Last, we show that purified LCMV-specific CD8 T cells rejected skin allografts in SCID mice. These findings therefore implicate a potential role for heterologous immunity in virus-induced allograft rejection...
- Direct alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivityGrégory Noël
Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, Quebec H7V 1B7, Canada
J Immunol 190:3764-71. 2013..Finally, late inhibition of Th1 differentiation was shown in indirect alloreactivity, but this suppression could also be mediated by Foxp3(+)-induced Tregs...
- Frequencies of SLC44A2 alleles encoding human neutrophil antigen-3 variants in the African American populationMichael J Huvard
Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Transfusion 52:1106-11. 2012..For Caucasian and Asian populations, SLC44A2 allele frequencies are known. Our primary objective was to determine the SLC44A2 allele frequencies in the African American population...
- Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cellsSiva Sivaganesh
Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
J Immunol 190:5829-38. 2013....
- The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R>Q154 amino acid substitutionBrian R Curtis
Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
Blood 115:2073-6. 2010....
- Geno- and phenotyping and immunogenicity of HNA-3Angelika Reil
DRK Blood Service West, Hagen, Germany
Transfusion 51:18-24. 2011..The HNA-3a/3b system results from a single-nucleotide exchange (461G>A; Arg154Gln) in the choline transporter-like protein 2 gene. Genotyping may allow identification of blood donors at risk to develop HNA-3a antibodies...
- Differential role of naïve and memory CD4 T-cell subsets in primary alloresponsesD Golshayan
Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland
Am J Transplant 10:1749-59. 2010..These findings have implications for better targeting of immunosuppression to inhibit immediate and later forms of alloimmunity...
- Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosisSteffen Klippel
Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, Breisacher Str 66, 79106 Freiburg, Germany
Blood 102:3569-74. 2003..In patients with erythrocytosis, the quantitative RT-PCR assay described here therefore provides a rapid, highly specific and sensitive tool for the diagnosis of PV...
- SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated proteinZhonglin Hao
Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia 22908, USA
Biol Reprod 66:735-44. 2002..Recombinant SAMP32 reacted with serum from an infertile man, suggesting that it is isoantigenic. Antibodies against recombinant SAMP32 inhibited both the binding and the fusion of human sperm to zona-free hamster eggs...
- JAK2 V617F mutation and PRV-1 overexpression: relevance in the diagnosis of polycythaemia vera and essential thrombocythaemiaS Melis
Laboratorium hematologie en moleculaire biologie, ZNA Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerpen
Acta Clin Belg 64:429-33. 2009..On the contrary, in the diagnosis of essential thrombocythaemia (ET), both JAK2 and PRV-1 show their usefulness...
- PRV-1 mRNA expression discriminates two types of essential thrombocythemiaM Griesshammer
Department of Medicine III, Hematology, Oncology, Rheumatology and Infectious Diseases, University of Ulm, Robert Koch Strasse 5, 89081 Ulm, Germany
Ann Hematol 83:364-70. 2004..003). We propose that PRV-1-positive ET comprise a pathophysiologically distinct subgroup of patients, one that is at risk for the development of complications and for the emergence of PV...
- In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation toleranceShuiping Jiang
Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London SE1 9RT, United Kingdom
Int Immunopharmacol 6:1879-82. 2006..These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance...
- The effect of the JAK2 V617F mutation on PRV-1 expressionZakar Mnjoyan
Haematologica 91:411-2. 2006..Compared to wild-type JAK2, the presence of JAK2(V617F) increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F-induced increase in PRV-1 expression...
- The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemiaPeter Johansson
Haematology and Coagulation Section, Department of Medicine, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
Eur J Haematol 70:358-62. 2003..005) relation between PRV-1 positivity and subnormal plasma EPO. No such relationship was present in the 28 ET patients who had received prior treatment with the above drugs (P = 0.147)...
- Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemiaEulàlia Puigdecanet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
Cancer Genet Cytogenet 167:39-42. 2006..Our results suggest a lack of structural and numerical rearrangements (deletions, translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients...
- Loss of direct and maintenance of indirect alloresponses in renal allograft recipients: implications for the pathogenesis of chronic allograft nephropathyR J Baker
Department of Immunology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
J Immunol 167:7199-206. 2001..These findings provide an insight into the pathogenesis of CAN and also have implications for the development of a clinical tolerance assay...
- Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophilsSusanne Bauer
Department of Clinical Sciences, Clinical Sciences in Lund, Lund University, 221 84 Lund, Sweden
J Leukoc Biol 81:458-64. 2007..PR3- and CD177-expressing neutrophils constitute a subpopulation of neutrophils with an unknown role in the innate immune system, which may play an important role in diseases such as Wegener's granulomatosis and polycythemia vera...
- Prevention of allograft tolerance by bacterial infection with Listeria monocytogenesTongmin Wang
Section of Transplantation, Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Immunol 180:5991-9. 2008..Our results indicate that bacterial exposure at the time of transplantation can antagonize tolerogenic regimens by enhancing alloantigen-specific immune responses independently of the generation of cross-reactive memory T cells...
- Regulatory CD25+ T cells in human kidney transplant recipientsAlan D Salama
Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 14:1643-51. 2003....
- Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicryJulia K Archbold
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
J Biol Chem 281:34324-32. 2006..This cross-reactivity underpins the T cell degeneracy inherent in the limited mature T cell repertoire that must respond to a vast diversity of microbial antigens...
- Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivityLiisa K Selin
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
J Am Soc Nephrol 18:2268-77. 2007....
- Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejectionP I Hornick
Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Circulation 101:2405-10. 2000..The purpose of this study was to determine whether T cells with indirect allospecificity could be detected in heart transplant recipients with chronic rejection...
- A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseasesLesley Ann Smyth
Department of Nephrology and Transplantation, Kings College London, Guy s Hospital, London, United Kingdom
Transplantation 82:S15-8. 2006..In this review, we discuss the possible contributions of the semidirect pathway/MHC transfer in infectious disease...
- IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivoM Hara
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 166:3789-96. 2001....
- Dependency of the trans vivo delayed type hypersensitivity response on the action of regulatory T cells: implications for monitoring transplant toleranceGregor Warnecke
Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
Transplantation 84:392-9. 2007..Here we tested the hypothesis that the assay can reveal control of allograft rejection by CD25CD4 regulatory T cells (Treg)...
- Dendritic cells: regulators of alloimmunity and opportunities for tolerance inductionAdrian E Morelli
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, W1544 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Immunol Rev 196:125-46. 2003..The remarkable heterogeneity and plasticity of these important APCs present additional challenges to optimizing DC-based therapies that may lead to improved tolerance-enhancing strategies in the clinic...
- The structural basis of T-cell allorecognitionA Whitelegg
The Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, UK
Tissue Antigens 63:101-8. 2004..Recognition of allogeneic MHC molecules is an inadvertent consequence of the need for TCR crossreactivity...
- Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouseE A Boyse
Proc R Soc Lond B Biol Sci 170:175-93. 1968
- T-cell allorecognition and transplant rejection: a summary and updatePeter S Heeger
Department of Immunology and The Glickman Urologic Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
Am J Transplant 3:525-33. 2003....
- Human neutrophil alloantigens systemsElyse Moritz
Disciplina de Hematologia e Hemoterapia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
An Acad Bras Cienc 81:559-69. 2009..Further studies in the field of neutrophil immunology will facilitate the prevention and management of transfusion reactions and immune diseases caused by neutrophil antibodies...
- Alloreactivity from human viral specific memory T-cellsL J A D'Orsogna
Dept of Immunohematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
Transpl Immunol 23:149-55. 2010..The possible implications for clinical solid organ and bone marrow transplantation and tolerance induction will be discussed...
- Donor reactive regulatory T cellsGang Feng
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
Curr Opin Organ Transplant 14:432-8. 2009..In this review we focus on the formation of the donor reactive Treg pool and explore the potential of these cells for therapeutic application in clinical transplantation...
- Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell linesMegan Dillon
Puget Sound Blood Center, Seattle, WA 98104, United States
Leuk Res 32:811-9. 2008..These results indicate a novel function for Prv-1 as a signaling molecule in cytokine signaling cascades and may lead to a greater understanding of the mechanism of overexpression of Prv-1 in myeloproliferative disorders...
- How a single T cell receptor recognizes both self and foreign MHCLeremy A Colf
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 129:135-46. 2007..Thus, a single TCR recognizes two globally similar, but distinct ligands by divergent mechanisms, indicating that receptor-ligand crossreactivity can occur in the absence of molecular mimicry...
- Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation toleranceKanji Nagahama
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Japan
Int Immunol 21:379-91. 2009....
- An investigation to assess the potential of CD25highCD4+ T cells to regulate responses to donor alloantigens in clinically stable renal transplant recipientsAhmed Akl
Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
Transpl Int 21:65-73. 2008....
- Regulatory cells in transplantationKathryn J Wood
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Novartis Found Symp 252:177-88; discussion 188-93, 203-10. 2003....
- Investigation of peptide involvement in T cell allorecognition using recombinant HLA class I multimersAlison M E Whitelegg
The Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
J Immunol 175:1706-14. 2005..The results show that these alloreactive populations comprise subsets of T cells, each specific for a self-peptide presented by foreign class I molecules, with no evidence of peptide-independent components...
- Alloantigen affinity and CD4 help determine severity of graft-versus-host disease mediated by CD8 donor T cellsXue Zhong Yu
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Immunol 176:3383-90. 2006..These findings underscore that alloantigen affinity and CD4 help control the fate and pathogenicity of alloreactive CD8+ T cells in vivo...
- Dominant transplantation tolerance impairs CD8+ T cell function but not expansionChun Yen Lin
Sir William Dunn School of Pathology, University of Oxford, UK
Nat Immunol 3:1208-13. 2002..These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses...
- Role of CD4+ and CD8+ T cells in allorecognition: lessons from corneal transplantationF Boisgerault
Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
J Immunol 167:1891-9. 2001..Although alloreactive CD8+ T cells are activated via the direct pathway, they are not fully competent and cannot contribute to the rejection unless they receive an additional signal provided by professional APCs in the periphery...
- Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivoGregor Warnecke
Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
Transplantation 83:1459-65. 2007..CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis...
- Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cellsRoss S Francis
Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford John Radcliffe Hospital, Oxford, UK
Eur J Immunol 41:726-38. 2011....
- CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responsesB R Blazar
Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
J Clin Invest 102:473-82. 1998..T cells had intact responses to antigens not present during tolerization. Tolerance was long lived and not readily reversible in vivo. These data have significant implications for the use of tolerization approaches to prevent human GVHD...
- The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiationJ M Rivas
Department of Immunology, University of Texas, M D Anderson Cancer Center Houston 77030
J Leukoc Biol 56:769-75. 1994..Because anti-IL-4 and anti-IL-10 did not block the activity of the UV Ts that regulate contact hypersensitivity, their effects appear to be mediated by a different mechanism...
- CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponsesCherry I Kingsley
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Immunol 168:1080-6. 2002..In clinical transplantation, the generation of regulatory T cells that could provide dynamic control of rejection responses is a possible route to permanent graft survival without the need for long-term immunosuppression...
- Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reactionSayuri Yamazaki
Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 103:2758-63. 2006..Therefore, alloantigen-selected Tregs are more effective suppressors of responses to major transplantation antigens, and these Tregs can be expanded from a polyclonal repertoire by DCs...
- CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigensXue Zhong Yu
Human Immunogenetics Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Clin Invest 113:1624-30. 2004..This study demonstrates that agonistic Ab's specific for the CD28 costimulatory molecule may be used as novel therapeutic agents to abrogate pathogenic T cell responses by selective depletion of activated T cells...
- Regulatory T cells in transplantationMahzuz Karim
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, UK
Curr Opin Immunol 14:584-91. 2002..Such cells have now been identified in humans as well as in rodents...
- Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survivalMasanori Abe
Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Transplant 5:1808-19. 2005..9 days, respectively). Thus, pre-pDC of donor origin have potential to regulate T-cell responses to alloantigens and can prolong organ graft survival...
- Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra veraSteffen Klippel
Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, and the Department of Hematology and Oncology, University Hospital Freiburg, Germany
Blood 100:2441-8. 2002..Therefore, quantification of PRV-1 surface expression cannot be used for the diagnosis of polycythemia vera...
- Regulatory T cells mediate maternal tolerance to the fetusVaruna R Aluvihare
Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Nat Immunol 5:266-71. 2004..Their absence led to a failure of gestation due to immunological rejection of the fetus...
- Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent processMahzuz Karim
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
J Immunol 172:923-8. 2004..These observations may have important implications for the design of protocols, both experimental and clinical, for the induction of tolerance to autoantigens or alloantigens in adults with limited thymic function...
- IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivoBirgit Sawitzki
Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, England, UK
J Exp Med 201:1925-35. 2005..These data support a unique role for IFN-gamma in the functional activity of alloantigen-reactive T reg cells during the development of operational tolerance to donor alloantigens in vivo...
- CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cellsHans J P M Koenen
Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Immunol 174:7573-83. 2005..Summarizing, the described procedure enables induction, expansion, and especially selection of highly suppressive, Ag-specific Treg subsets, which are crucial in Ag-specific, Treg-based immunotherapy...
- The complementary roles of deletion and regulation in transplantation toleranceRobert I Lechler
Department of Immunology, Division of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, Commonwealth Building, Du Cane Road, London W12 0NN, UK
Nat Rev Immunol 3:147-58. 2003..This review outlines our current understanding of the mechanisms of allograft tolerance, emphasizing the complementary roles of deletion and regulation of alloreactive T cells...
- Detection of alloreactive T cells by flow cytometry: a new test compared with limiting dilution assayAalzen de Haan
Medical Biology Section of Pathology and Laboratory Medicine, Groningen, The Netherlands
Transplantation 74:562-70. 2002..To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared these frequencies with classical LDA estimates of frequencies...
- CD4+CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patientsDavid S Game
Department of Immunology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
J Am Soc Nephrol 14:1652-61. 2003..It is concluded that the action of CD4(+)CD25(+) regulatory cells is not the main mechanism of donor-specific hyporesponsiveness in the direct pathway of allorecognition...
- A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBAH Havelková
Institute of Molecular Genetics, Academy of Sciences, Czech Republic, Fleming nám 2, 166 37 Prague 6, Czech Republic
Genes Immun 1:483-7. 2000....
- Human vascular endothelial cells stimulate a lower frequency of alloreactive CD8+ pre-CTL and induce less clonal expansion than matching B lymphoblastoid cells: development of a novel limiting dilution analysis method based on CFSE labeling of lymphocytesT J Dengler
Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
J Immunol 166:3846-54. 2001....
- Tolerogenic response: allorecognition pathwaysA Caballero
Servicio de Inmunologia, Hospital Regional Universitario Carlos Haya, 29010 Malaga, Spain
Transpl Immunol 17:3-6. 2006..Nonetheless, a number of studies are only fully understood when a third proposed allorecognition mechanism is taken into account. This is the semi-indirect pathway, as discussed in this short report...
- Quantifying the frequency of alloreactive T cells in vivo: new answers to an old questionE J Suchin
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 166:973-81. 2001..Bystander proliferation is negligible, revealing exquisite specificity to the alloresponse. These data provide a novel approach to quantify alloreactive T cell responses during specific immunomodulatory strategies in vivo...
- Trafficking of host- and donor-derived dendritic cells in rat cardiac transplantation: allosensitization in the spleen and hepatic nodesT Saiki
Department of Anatomy I, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan
Transplantation 71:1806-15. 2001....
- Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humansMaria Grazia Roncarolo
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
Nat Rev Immunol 7:585-98. 2007....
- Contributions of direct and indirect T cell alloreactivity during allograft rejection in miceG Benichou
Department of Surgery, University of California, San Francisco 94114, USA
J Immunol 162:352-8. 1999..This work provides a new approach for analysis of the immunophysiology of allograft rejection and should be useful for monitoring immune responses to graft Ags in human transplant recipients...
- Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient miceZ Dai
The Carlos and Marguerite Mason Transplantation Research Center, Emory University and Veterans Affairs Medical Center, Atlanta, GA 30033, USA
J Immunol 161:1659-63. 1998..These findings indicate that endogenous IL-2 is required for the induction of long-term allograft survival, and that IL-2 regulates alloimmune responses by preparing activated T lymphocytes for alloantigen-induced apoptosis...
- Allogeneic stimulation of naturally occurring CD4+CD25+ T cells induces strong regulatory capacity with increased donor-reactivityJeroen J A Coenen
Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Transpl Immunol 17:237-42. 2007..We propose that selectively favoring the effects of alloreactive T(REG) is a pivotal element in inducing graft acceptance...
- Murine Ly-6 multigene family is located on chromosome 15K P LeClair
Proc Natl Acad Sci U S A 84:1638-42. 1987..The possible involvement of the Ly-6 lymphocyte activation and differentiation antigen genes in chromosome 15-related lymphoid malignancies is discussed...
- T-cell allorecognition: a case of mistaken identity or déjà vu?Julia K Archbold
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Trends Immunol 29:220-6. 2008....
- Characterization of intraocular immunopathology following intracameral inoculation with alloantigenDaniel R Saban
Department of Pathology, University of Florida, Gainesville, FL, USA
Mol Vis 14:615-24. 2008..Thus, the current study was undertaken to detect and characterize potential pathological effects on intraocular tissues following intracameral inoculation with alloantigen...
- Granulocyte antigens and antibody detectionD Stroncek
Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Maryland, USA
Vox Sang 87:91-4. 2004
- A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificityM D Tallquist
Department of Immunology, Mayo Foundation, Rochester, Minnesota 55905, USA
J Exp Med 184:1017-26. 1996..The endogenous protein, MLRQ, contains a peptide sequence identical to dEV-8. This degenerate recognition of two distinct peptide/MHC complexes by a single TCR has important implications for understanding allorecognition...
- Monoclonal antibody GB24 recognizes a trophoblast-lymphocyte cross-reactive antigenB L Hsi
INSERM U210, , Nice, France
Am J Reprod Immunol Microbiol 18:21-7. 1988..Microvilli from different placentae revealed substantial differences regarding the intensity of the labeling of these two bands, suggesting that the antigens recognized by GB24 are probably allotypic...
- Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapyJorieke H Peters
Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 3:e2233. 2008..For the human setting, information is lacking on how to generate Treg with direct antigen-specificity ex vivo to be used for immunotherapy...
- Human neutrophil antigen-4a gene frequencies in an Australian population, determined by a new polymerase chain reaction method using sequence-specific primersH D Clague
Queensland Institute of Medical Research, Australian Red Cross Blood Service, Brisbane, Queensland, Australia
Transfus Med 13:149-52. 2003..The gene frequency was found to be 0.906, which is the same as in the American population. The PCR-SSP genotyping method perfectly correlates with serological phenotyping and is efficient for screening large numbers of samples...
- Platelet and granulocyte glycoprotein polymorphismsG F Lucas
International Blood Group Reference Laboratory, Bristol, UK
Transfus Med 10:157-74. 2000
- Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodiesAkhil Maheshwari
Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine and All Children s Hospital, St Petersburg, Florida 33701, USA
Pediatrics 109:e64. 2002....
- Neutrophil alloantigensDavid Stroncek
Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892 1184, USA
Transfus Med Rev 16:67-75. 2002..New polymorphisms in these antigen systems are still being described, but the complete understanding of these neutrophil antigen systems has been slow because of the complexity of these genes...
- The risk of antibody formation against HNA1a and HNA1b granulocyte antigens during pregnancy and its relation to neonatal neutropeniaB Zupanska
Department of Immunohaematology and Immunology of Transfusion Medicine, Institute of Haematology and Blood Transfusion, 5 Chocimska Str, 00 957 Warsaw, Poland
Transfus Med 11:377-82. 2001..A comparison with our previous, unpublished data suggests that the incidence of severe NAIN is roughly 1 per 6000 (four cases among 24101 newborns)...
- CD3+CD4-CD8- alphabeta-TCR+ T cell as immune regulatory cellZ X Zhang
Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2 815, Toronto, M5A 1E7, Canada
J Mol Med (Berl) 79:419-27. 2001....
- Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosisTarek El-Sawy
Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Pathol 165:147-57. 2004..These data demonstrate CD8+ T cell-mediated attack on the vascular endothelium of allografts within hours following organ reperfusion that amplifies innate immune-mediated intra-graft inflammation and necrosis...
- Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway diseaseErin E West
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Am J Respir Cell Mol Biol 34:108-18. 2006....
- Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APCTara M Strutt
Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
Int Immunol 18:719-28. 2006..These different requirements for activation could reflect the fact that thymocytes have not received an exit-thymus signal and/or that splenic T cells are heterogeneous, containing naive, memory and partially-activated T cells...
- Dipeptide boronic acid, a novel proteasome inhibitor, prevents islet-allograft rejectionYulian Wu
Laboratory of Immunology, Centre hospitalier de l Universite de Montreal CHUM Notre Dame Hospital, Montreal, Quebec, Canada
Transplantation 78:360-6. 2004..This implies that they could be used as a novel category of immunosuppressants to block allograft rejection. Therefore, in this study, dipeptide boronic acid (DPBA) was tested for its effect on mouse islet transplantation...
- Peripheral T Cell tolerance by targeting AKTClaudio Anasetti; Fiscal Year: 2010..The proposed studies will definitely evaluate the efficacy and mechanisms of TCN in controlling GVHD in clinically relevant models of BMT, and may point to a novel and more selective strategy to prevent GVHD in the clinic. ..
- Mechanisms of Sensitization in High Risk Corneal GraftsReza Dana; Fiscal Year: 2013....
- Definition of an Ancient T cell-like System in LampreysMAX DALE COOPER; Fiscal Year: 2013..Candidate histocompatibility genes will be examined for genetic polymorphism, expression patterns and immunostimulatory potential. ..
- VIRAL INFECTION INFLUENCE ON TRANSPLANTATION TOLERANCEDALE LESLIE GREINER; Fiscal Year: 2013..This work will identify how infection during transplantation may affect the host immune system and ultimate fate of the graft. ..
- The role of tolerogenic dendritic cells in islet-cell allograft transplantationSHERRIE JILL DIVITO; Fiscal Year: 2010..Therefore, the development of cellular based therapies that prolong islet-cell transplant survival by inducing donor-specific tolerance without side effects is clearly advantageous. ..
- NK and T Cell Regulation of ES-Derived Hematopoietic Progenitor Cell EngraftmentWILLIAM TABAYOYONG; Fiscal Year: 2010..When completed, these studies will provide a characterization of the immune response directed against transplanted ES-derived HPC and may provide further insight into the immunobiology of other ES-derived cellular therapies. ..
- Molecular pathogenesis of anti-glomerular basement membrane nephritisDorin Bogdan Borza; Fiscal Year: 2012..These studies may identify factors that increase the risk of disease, suggest how to avoid disease in people at risk, and yield better treatments of established disease. ..
- Post-Transplant Inflammatory ResponseRobert L Fairchild; Fiscal Year: 2012....
- Novel Therapies for Chronic Renal Allograft Dysfunction in ChildrenWilliam E Harmon; Fiscal Year: 2012..The main goal of these studies is to understand the mechanisms of action of belatacept/AEB071 and to develop a set of surrogate biomarkers of chronic allograft dysfunction and stability in pediatric kidney transplant recipients. ..
- DC-ASGPR AS A NOVEL TARGET FOR CONTROLLING GVHD AND ALLOGRAFT REJECTIONSangKon Oh; Fiscal Year: 2013..More importantly, data generated from this study will support humanization of our novel antibody for the rational design and development of novel immunotherapeutics for patients who undergo transplantation in the near future. ..
- Consequences of Aging on Immune Response and Transplant OutcomeSTEFAN GUNTHER TULLIUS; Fiscal Year: 2013..Therefore, this study is important because it is novel and it will permit us to develop effective and new therapies to prevent allograft rejection in elderly patients. ..
- Presentation of Alloantigen by Human Vascular CellsJordan S Pober; Fiscal Year: 2013..This characterization of EC presentation of alloantigen can lead to new strategies to reduce organ rejection in the clinic which remains as a major cause of allograft failure. ..
- "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation"Qizhi Tang; Fiscal Year: 2013..It is strongly aligned with NIAID's goal to "evaluate approaches that include tolerogenic, anti-inflammatory, and immunomodulatory strategies to treat and prevent immune-mediated diseases". ..
- Novel Therapies to Improve Renal and Cardiac Allograft OutcomesAnil Chandraker; Fiscal Year: 2013..Our studies have major implications for improving outcomes of solid organ transplant recipients. ..
- Maternal Microchimerism and Neonatal ToleranceWilliam J Burlingham; Fiscal Year: 2013....
- Migration and Trafficking in Tolerance 10/07Jonathan S Bromberg; Fiscal Year: 2012..The ability to define these interactions and achieve tolerance is important for achieving good graft survival and patient survival for transplant recipients. ..
- Induction and Migration of Regulatory T CellsJonathan S Bromberg; Fiscal Year: 2013..The ability to define these interactions and achieve tolerance is important for achieving good graft survival and patient survival for transplant recipients. ..
- Role of T cell Specific Adaptor Protein in AlloimmunityDavid M Briscoe; Fiscal Year: 2012....
- Activation of the alloimmune responseJagdeep S Obhrai; Fiscal Year: 2012..The Center brings together investigators with diverse expertise who are focused on the science of transplantation to improve the lives of transplant recipients. ..
- Signals Affecting Homestasis and Tolerance in Memory T CellsJonathan S Maltzman; Fiscal Year: 2013..We propose to define and dissect the effect of infection on homeostasis of memory T cells and transplantation by combining viral infection models with conditional gene deletion and studies on transplantation tolerance. ..
- ANERGY, APOPTOSIS AND CD28 IN CD8+ T CELLS DURING AIDSDorothy E Lewis; Fiscal Year: 2010..Because CD8+ T cells are important for HIV control, these studies are important for development of immune intervention strategies and for vaccine design. ..
- Transfusion-associated immune hemolysisKarina Yazdanbakhsh; Fiscal Year: 2010..In our grant application, we will expand our animal studies to focus on the triggers that make immune cells accept or reject transfused blood. ..
- A Randomized Trial of Tac/MTX/bortezomib vs Tac/MTXplacebo in Allogeneic HSCTJoseph H Antin; Fiscal Year: 2013..It will also shed important light on the pathophysiology of GVHD that can be applied to future studies. ..
- Alloantigen Delivery Via ECDI-Fixed Cells For Tolerance To Monkey Islet GraftsStephen D Miller; Fiscal Year: 2013..The proposed studies will provide novel insights into the role of ADEC and concomitant immunotherapy for tolerance induction to islet allografts, a critical step toward clinical translaton of this antigen-specific tolerance strategy. ..
- Adoptive Transfer of Donor Tregs Specific Against Host Alloantigens for PresentioClaudio Anasetti; Fiscal Year: 2013..By trace-labeling the Tregs, we will also assess Treg repopulation and survival after adoptive transfer to allograft recipients. ..
- Lymphoid Structure in ToleranceJonathan S Bromberg; Fiscal Year: 2010....
- Characterization of Tau Lymphocyte Modulation in PregnancyLEELA E NORONHA; Fiscal Year: 2010..Furthermore, the immunological concepts surrounding this process are also relevant to the fields of transplantation biology, cancer, and infectious diseases. ..
- B-Lymphocyte Repertoire Remodeling for Transplantation ToleranceHooman Noorchashm; Fiscal Year: 2010..In this application, we propose a novel avenue of investigations into the possiblity of inducing donor specific immunological tolerance to allografts by targeting recipient B- lymphocytes. ..
- Alemtuzumab and Regulatory T Cells for Heart Transplant Tolerance in MonkeysAngus W Thomson; Fiscal Year: 2013..abstract_text> ..
- Alloreactive Regulatory T cells control GVHD and maintain GVL effectXue Zhong Yu; Fiscal Year: 2013....
- Lymphoid Structure in Tolerance: Role of Stromal CellsJonathan S Bromberg; Fiscal Year: 2012....
- CMV-Specific CD8+ T Cell Responses in Kidney Transplant RecipientsLAURA L GIBSON; Fiscal Year: 2010..These studies will contribute new knowledge to aid in the rational development of effective CMV prevention and treatment strategies for populations at risk for severe CMV disease. ..
- Innate Recognition of Allogeneic Non-SelfFadi G Lakkis; Fiscal Year: 2013..abstract_text> ..
- CXCL9 influences effector T cell priming to cardiac allograftsJoshua M Rosenblum; Fiscal Year: 2010....
- Genomics of Chronic Renal Allograft RejectionBarbara T Murphy; Fiscal Year: 2012..The results of these studies will lend greater insight to the underlying mechanisms leading to chronic rejection and help differentiate one cause of CAN. ..
- IMMUNOGENETICS OF MARROW ALLOGRAFTINGJohn Hansen; Fiscal Year: 1992..The research question addressed in Project 6 is whether the microvariants defined by individual HLA alleles have a significant impact on GVHD...
- PRESERVATION AND CARDIAC TRANSPLANT VASCULOPATHYDavid Pinsky; Fiscal Year: 2003..These experiments will provide new insights into mechanisms by which early ischemic injury leads to early graft failure and TCAD, and proffer new strategies for prevention. ..
- NOVEL COFACTOR ANALOGUES AS IMMUNOSUPPRESSANTSKrzysztof Pankiewicz; Fiscal Year: 2000..However, its clinical use is limited due to undesirable metabolism. Certainly, new and specific inhibitors of IMPDH are expected to be of great therapeutic interest and commercial potential. ..
- PRECLINICAL BRIDGE TO HUMAN TRANSPLANT TOLERANCEJudith Thomas; Fiscal Year: 2000..The information gained in these studies is expected to guide successful application of tolerance induction to human transplantation. ..
- Immunopathogenesis of Chronic Allograft RejectionMOHAMED SAYEGH; Fiscal Year: 2005..abstract_text> ..
- Ex Vivo Alloanergization to Improve Immunity After Haploidentical TransplantEva C Guinan; Fiscal Year: 2010..the number of tolerized donor immune cells necessary to improve immune function after mismatched HSCT without contributing to GVHD, and perform laboratory experiments to characterize the mechanisms by which these goals are achieved ..
- Movement of Recipient T-Cells Away From an AllograftMark Poznansky; Fiscal Year: 2003....
- P-glycoprotein Function in Allograft RejectionMarkus Frank; Fiscal Year: 2004....
- T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETIONAndrew Mellor; Fiscal Year: 2002....
- Phase I Study of BB3 in Dialysis PatientsWeizhong Cai; Fiscal Year: 2009..The data from these two clinical studies form a solid basis for the Phase II study in renal transplantation. PUBLIC HEALTH RELEVANCE: A small molecule organ protective agent has significant clinical potential in renal transplantation. ..
- Role of Host Dendritic Cells in Heart Transplant VasculopathyZhiliang Wang; Fiscal Year: 2007..We believe the data from the proposal will lead to better understanding of the pathogenesis and therapy of graft chronic rejection. [unreadable] [unreadable]..
- STEM CELLS AND ACCESSORY CELLS IN PERIPHERAL BLOODBeverly Torok Storb; Fiscal Year: 2003..Our final goal is to use the G-PBMC product to establish a non-toxic conditioning regimen to achieve stable mixed chimerism in haploidentical donor/recipient pairs. ..
- Immunomodulation by MHC Class II PeptidesBarbara Murphy; Fiscal Year: 2005..These studies will help elucidate the potential role of MHC class II peptides in the prevention of transplant rejection and the induction of tolerance. ..
- MOLECULAR IMMUNOLOGY OF MINOR HISTOCOMPATIBILITY ANTIGENSebastian Joyce; Fiscal Year: 2009..Additionally, the beneficial effects of graft-versus-leukemia, a by-product of GvHD, can be utilised as a therapy against cancers. ..
- Effector Mechanisms in Graft ToleranceRandolph J Noelle; Fiscal Year: 2010..New evidence strongly implicates IL-9 and mast cells as elements that may be important to peripheral tolerance, and studies are presented to functionally implicate their involvement. ..
- Induction of T Cell Chemoattractants in Acute RejectionRobert Fairchild; Fiscal Year: 2007..abstract_text> ..
- TRANSPLANTATION TOLERANCE :T CELL TRAFFICKINGJonathan Bromberg; Fiscal Year: 2001..2) Determine what other receptors and ligands are important for lymph node localization and tolerance induction. 3) Determine the role of other cells and anatomic sites during tolerance induction. ..
- IMMUNE MECHANISMS OF CHRONIC ALLOGRAFT REJECTIONCharles Carpenter; Fiscal Year: 2000..The above studies should provide relevant information for development of novel strategies to prevent and possibly interrupt chronic allograft rejection in clinical transplantation. ..
- T Cells in the Pathogenesis of Systemic SclerosisChris Platsoucas; Fiscal Year: 2005..d. To identify Thl, Th2, suppressor, anergic and CTL T-cell clones from those developed above, on the basis of expression patterns of their genes, using DNA array technology. ..
- BLOOD GROUP ANTIGENS AND ANTIBODIESJAMES MOHN; Fiscal Year: 1980..The major approach focuses on the fundamental immunologic characteristics of human blood group isoantigens and antibodies in attempts to determine the structural basis for immunologic specificity and to relate their ..
- MODELING OF PLATELET ALLOANTIGENSEmily Barron Casella; Fiscal Year: 2002..The ability of HPA-1a murine GPIIIa to assemble into a fibrinogen receptor and bind ligand in transfected megakaryoblastic cells will also be tested. ..
- CYTOTOXIC CELLS AND ALLOIMMUNE RESPONSESDwain Thiele; Fiscal Year: 2002..These studies should provide new insights into the regulation of CTL effector mechanisms and the role that such effector mechanisms play in complications of bone marrow and organ transplantation. ..
- VASCULAR DISEASE IN HUMAN HEART TRANSPLANTATIONGeraldine Miller; Fiscal Year: 2003..These studies will enhance our understanding of the factors within allograft environments that, together with antigen recognition, lead to T cell activation and survival and the translation of these events to CAV. ..
- CYTOKINES AND LIVER TRANSPLANTATIONOLIVIA MARTINEZ; Fiscal Year: 2003..abstract_text> ..
- NON-MHC ANTIGEN ROLE IN RENAL & CARDIAC TRANSPLANTATIONThalachallour Mohanakumar; Fiscal Year: 2000....
- T CELL ACTIVIATION BY DISTINCT ANTIGEN PRESENTING CELLSSeth Stevens; Fiscal Year: 2002..Signaling through VLA-5 is hypothesized to be transduced via the receptor tyrosine kinase, MAP kinase pathway. ..
- INTRATHYMIC TRANSPLANTATION TOLERANCE BY MHC PEPTIDESMOHAMED SAYEGH; Fiscal Year: 2003..Results from these studies should yield clinically relevant information facilitating development of novel strategies to induce donor-specific tolerance. ..
- The CD40-CD154 pathway in chronic allograft rejectionAnil Chandraker; Fiscal Year: 2005..Understanding the mechanisms of how alloantigen dependent and independent pathways contribute to the overall process may provide novel therapeutic approaches for modulating the effects of chronic allograft rejection. ..