isoantigens

Summary

Summary: Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.

Top Publications

  1. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
  2. ncbi Regulatory T cells in transplantation tolerance
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Nat Rev Immunol 3:199-210. 2003
  3. ncbi Human neutrophil alloantigens
    J Bux
    Blood Service West of the German Red Cross, Feithstrasse 182, 58097 Hagen, Germany
    Vox Sang 94:277-85. 2008
  4. ncbi Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients
    Nicole A Mifsud
    Department of Medicine, Monash University, Central Clinical School, The Alfred Hospital, Melbourne, Victoria, Australia
    Transplantation 90:1439-49. 2010
  5. pmc Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
    J Exp Med 193:1295-302. 2001
  6. ncbi Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
    Timucin Taner
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, PA, USA
    Am J Transplant 5:228-36. 2005
  7. ncbi Allorecognition and the alloresponse: clinical implications
    B Afzali
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital Campus, London, UK
    Tissue Antigens 69:545-56. 2007
  8. ncbi The frequencies of human neutrophil alloantigens in the Chinese Han population of Guangzhou
    Wenjie Xia
    Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, Guangdong, China
    Transfusion 51:1271-7. 2011
  9. ncbi Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2
    E Moritz
    Discipline of Hematology and Hemotherapy, Federal University of Sao Paulo, Sao Paulo, Brazil
    Vox Sang 98:160-6. 2010
  10. ncbi Specificity of T-cell alloreactivity
    Nathan J Felix
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Immunol 7:942-53. 2007

Detail Information

Publications226 found, 100 shown here

  1. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
  2. ncbi Regulatory T cells in transplantation tolerance
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Nat Rev Immunol 3:199-210. 2003
    ....
  3. ncbi Human neutrophil alloantigens
    J Bux
    Blood Service West of the German Red Cross, Feithstrasse 182, 58097 Hagen, Germany
    Vox Sang 94:277-85. 2008
    ..This review describes alloantigens currently listed in the human neutrophil alloantigen (HNA) system...
  4. ncbi Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients
    Nicole A Mifsud
    Department of Medicine, Monash University, Central Clinical School, The Alfred Hospital, Melbourne, Victoria, Australia
    Transplantation 90:1439-49. 2010
    ....
  5. pmc Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
    J Exp Med 193:1295-302. 2001
    ....
  6. ncbi Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
    Timucin Taner
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, PA, USA
    Am J Transplant 5:228-36. 2005
    ..These therapeutic effects, achieved by targeting both major pathways of allorecognition, provide the basis for a clinically applicable strategy to suppress graft rejection...
  7. ncbi Allorecognition and the alloresponse: clinical implications
    B Afzali
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital Campus, London, UK
    Tissue Antigens 69:545-56. 2007
    ..As the understanding of these processes improves, the ability to generate clinically viable immunotherapies will increase...
  8. ncbi The frequencies of human neutrophil alloantigens in the Chinese Han population of Guangzhou
    Wenjie Xia
    Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, Guangdong, China
    Transfusion 51:1271-7. 2011
    ..This study aimed to determine the frequencies of HNAs in the major Han ethnic group living in Guangdong Province, Southern China...
  9. ncbi Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2
    E Moritz
    Discipline of Hematology and Hemotherapy, Federal University of Sao Paulo, Sao Paulo, Brazil
    Vox Sang 98:160-6. 2010
    ....
  10. ncbi Specificity of T-cell alloreactivity
    Nathan J Felix
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Immunol 7:942-53. 2007
    ....
  11. pmc Pathways of major histocompatibility complex allorecognition
    Behdad Afzali
    Department of Nephrology and Transplantation, Guy s Hospital, Kings College London, London, UK
    Curr Opin Organ Transplant 13:438-44. 2008
    ..Here, we review the pathways of allorecognition and their potential relevance to the balance between regulatory and effector responses following transplantation...
  12. ncbi Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings
    Li Ping Jin
    Laboratory for Reproductive Immunology, Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, China
    J Immunol 173:3612-9. 2004
    ..This procedure might be considered potentially useful for fetal survival when used as an immunotherapy for human recurrent spontaneous abortion...
  13. ncbi Monitoring of indirect allorecognition: wishful thinking or solid data?
    M M Waanders
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Tissue Antigens 71:1-15. 2008
    ....
  14. ncbi Abrogation of antibody-mediated allograft rejection by regulatory CD4 T cells with indirect allospecificity
    Chris J Callaghan
    University Department of Surgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Immunol 178:2221-8. 2007
    ..Their development is associated with intrinsic tolerance within the alloantigen-specific B cell compartment that persists after T cell help is made available...
  15. ncbi Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymis
    Jayasimha Rao
    Department of Cell Biology and the Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 68:290-301. 2003
    ..The presence of a defensin-like motif suggests that E-3 may play a role in protecting the sperm from microbial infections in the epididymis and in the female reproductive tract...
  16. ncbi Gene frequencies of the HNA-4a and -5a neutrophil antigens in Brazilian persons and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-5a genotyping
    José Daniel Braz Cardone
    Discipline of Hematology and Hemotherapy, Federal University of Sao Paulo, Sao Paulo, Brazil
    Transfusion 46:1515-20. 2006
    ..HNA-4a has been linked to alloimmune neonatal neutropenia, but the HNA-5a clinical significance is unclear...
  17. ncbi The importance of the indirect pathway of allorecognition in clinical transplantation
    M Refik Gökmen
    Immunoregulation Laboratory, King s College London, 5th Floor, Southwark Wing, Guy s Hospital, Great Maze Pond, London SE1 9RT, United Kingdom
    Curr Opin Immunol 20:568-74. 2008
    ..An improved understanding of the indirect pathway is likely to bring important benefits to transplant recipients...
  18. pmc Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity
    M A Brehm
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Transplant 10:1738-48. 2010
    ..Last, we show that purified LCMV-specific CD8 T cells rejected skin allografts in SCID mice. These findings therefore implicate a potential role for heterologous immunity in virus-induced allograft rejection...
  19. ncbi Direct alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivity
    Grégory Noël
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, Quebec H7V 1B7, Canada
    J Immunol 190:3764-71. 2013
    ..Finally, late inhibition of Th1 differentiation was shown in indirect alloreactivity, but this suppression could also be mediated by Foxp3(+)-induced Tregs...
  20. pmc Frequencies of SLC44A2 alleles encoding human neutrophil antigen-3 variants in the African American population
    Michael J Huvard
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Transfusion 52:1106-11. 2012
    ..For Caucasian and Asian populations, SLC44A2 allele frequencies are known. Our primary objective was to determine the SLC44A2 allele frequencies in the African American population...
  21. pmc Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells
    Siva Sivaganesh
    Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Immunol 190:5829-38. 2013
    ....
  22. pmc The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R>Q154 amino acid substitution
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Blood 115:2073-6. 2010
    ....
  23. ncbi Geno- and phenotyping and immunogenicity of HNA-3
    Angelika Reil
    DRK Blood Service West, Hagen, Germany
    Transfusion 51:18-24. 2011
    ..The HNA-3a/3b system results from a single-nucleotide exchange (461G>A; Arg154Gln) in the choline transporter-like protein 2 gene. Genotyping may allow identification of blood donors at risk to develop HNA-3a antibodies...
  24. ncbi Differential role of naïve and memory CD4 T-cell subsets in primary alloresponses
    D Golshayan
    Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland
    Am J Transplant 10:1749-59. 2010
    ..These findings have implications for better targeting of immunosuppression to inhibit immediate and later forms of alloimmunity...
  25. ncbi Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis
    Steffen Klippel
    Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, Breisacher Str 66, 79106 Freiburg, Germany
    Blood 102:3569-74. 2003
    ..In patients with erythrocytosis, the quantitative RT-PCR assay described here therefore provides a rapid, highly specific and sensitive tool for the diagnosis of PV...
  26. ncbi SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein
    Zhonglin Hao
    Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 66:735-44. 2002
    ..Recombinant SAMP32 reacted with serum from an infertile man, suggesting that it is isoantigenic. Antibodies against recombinant SAMP32 inhibited both the binding and the fusion of human sperm to zona-free hamster eggs...
  27. ncbi JAK2 V617F mutation and PRV-1 overexpression: relevance in the diagnosis of polycythaemia vera and essential thrombocythaemia
    S Melis
    Laboratorium hematologie en moleculaire biologie, ZNA Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerpen
    Acta Clin Belg 64:429-33. 2009
    ..On the contrary, in the diagnosis of essential thrombocythaemia (ET), both JAK2 and PRV-1 show their usefulness...
  28. ncbi PRV-1 mRNA expression discriminates two types of essential thrombocythemia
    M Griesshammer
    Department of Medicine III, Hematology, Oncology, Rheumatology and Infectious Diseases, University of Ulm, Robert Koch Strasse 5, 89081 Ulm, Germany
    Ann Hematol 83:364-70. 2004
    ..003). We propose that PRV-1-positive ET comprise a pathophysiologically distinct subgroup of patients, one that is at risk for the development of complications and for the emergence of PV...
  29. ncbi In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance
    Shuiping Jiang
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London SE1 9RT, United Kingdom
    Int Immunopharmacol 6:1879-82. 2006
    ..These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance...
  30. ncbi The effect of the JAK2 V617F mutation on PRV-1 expression
    Zakar Mnjoyan
    Haematologica 91:411-2. 2006
    ..Compared to wild-type JAK2, the presence of JAK2(V617F) increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F-induced increase in PRV-1 expression...
  31. ncbi The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia
    Peter Johansson
    Haematology and Coagulation Section, Department of Medicine, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Eur J Haematol 70:358-62. 2003
    ..005) relation between PRV-1 positivity and subnormal plasma EPO. No such relationship was present in the 28 ET patients who had received prior treatment with the above drugs (P = 0.147)...
  32. ncbi Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia
    Eulàlia Puigdecanet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 167:39-42. 2006
    ..Our results suggest a lack of structural and numerical rearrangements (deletions, translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients...
  33. ncbi Loss of direct and maintenance of indirect alloresponses in renal allograft recipients: implications for the pathogenesis of chronic allograft nephropathy
    R J Baker
    Department of Immunology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    J Immunol 167:7199-206. 2001
    ..These findings provide an insight into the pathogenesis of CAN and also have implications for the development of a clinical tolerance assay...
  34. ncbi Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils
    Susanne Bauer
    Department of Clinical Sciences, Clinical Sciences in Lund, Lund University, 221 84 Lund, Sweden
    J Leukoc Biol 81:458-64. 2007
    ..PR3- and CD177-expressing neutrophils constitute a subpopulation of neutrophils with an unknown role in the innate immune system, which may play an important role in diseases such as Wegener's granulomatosis and polycythemia vera...
  35. pmc Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes
    Tongmin Wang
    Section of Transplantation, Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 180:5991-9. 2008
    ..Our results indicate that bacterial exposure at the time of transplantation can antagonize tolerogenic regimens by enhancing alloantigen-specific immune responses independently of the generation of cross-reactive memory T cells...
  36. ncbi Regulatory CD25+ T cells in human kidney transplant recipients
    Alan D Salama
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 14:1643-51. 2003
    ....
  37. ncbi Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry
    Julia K Archbold
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 281:34324-32. 2006
    ..This cross-reactivity underpins the T cell degeneracy inherent in the limited mature T cell repertoire that must respond to a vast diversity of microbial antigens...
  38. ncbi Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Am Soc Nephrol 18:2268-77. 2007
    ....
  39. ncbi Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection
    P I Hornick
    Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Circulation 101:2405-10. 2000
    ..The purpose of this study was to determine whether T cells with indirect allospecificity could be detected in heart transplant recipients with chronic rejection...
  40. ncbi A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases
    Lesley Ann Smyth
    Department of Nephrology and Transplantation, Kings College London, Guy s Hospital, London, United Kingdom
    Transplantation 82:S15-8. 2006
    ..In this review, we discuss the possible contributions of the semidirect pathway/MHC transfer in infectious disease...
  41. ncbi IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
    ....
  42. ncbi Dependency of the trans vivo delayed type hypersensitivity response on the action of regulatory T cells: implications for monitoring transplant tolerance
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Transplantation 84:392-9. 2007
    ..Here we tested the hypothesis that the assay can reveal control of allograft rejection by CD25CD4 regulatory T cells (Treg)...
  43. ncbi Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction
    Adrian E Morelli
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, W1544 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Immunol Rev 196:125-46. 2003
    ..The remarkable heterogeneity and plasticity of these important APCs present additional challenges to optimizing DC-based therapies that may lead to improved tolerance-enhancing strategies in the clinic...
  44. ncbi The structural basis of T-cell allorecognition
    A Whitelegg
    The Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, UK
    Tissue Antigens 63:101-8. 2004
    ..Recognition of allogeneic MHC molecules is an inadvertent consequence of the need for TCR crossreactivity...
  45. ncbi Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse
    E A Boyse
    Proc R Soc Lond B Biol Sci 170:175-93. 1968
  46. ncbi T-cell allorecognition and transplant rejection: a summary and update
    Peter S Heeger
    Department of Immunology and The Glickman Urologic Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 3:525-33. 2003
    ....
  47. ncbi Human neutrophil alloantigens systems
    Elyse Moritz
    Disciplina de Hematologia e Hemoterapia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    An Acad Bras Cienc 81:559-69. 2009
    ..Further studies in the field of neutrophil immunology will facilitate the prevention and management of transfusion reactions and immune diseases caused by neutrophil antibodies...
  48. ncbi Alloreactivity from human viral specific memory T-cells
    L J A D'Orsogna
    Dept of Immunohematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
    Transpl Immunol 23:149-55. 2010
    ..The possible implications for clinical solid organ and bone marrow transplantation and tolerance induction will be discussed...
  49. ncbi Donor reactive regulatory T cells
    Gang Feng
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Curr Opin Organ Transplant 14:432-8. 2009
    ..In this review we focus on the formation of the donor reactive Treg pool and explore the potential of these cells for therapeutic application in clinical transplantation...
  50. ncbi Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines
    Megan Dillon
    Puget Sound Blood Center, Seattle, WA 98104, United States
    Leuk Res 32:811-9. 2008
    ..These results indicate a novel function for Prv-1 as a signaling molecule in cytokine signaling cascades and may lead to a greater understanding of the mechanism of overexpression of Prv-1 in myeloproliferative disorders...
  51. ncbi How a single T cell receptor recognizes both self and foreign MHC
    Leremy A Colf
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:135-46. 2007
    ..Thus, a single TCR recognizes two globally similar, but distinct ligands by divergent mechanisms, indicating that receptor-ligand crossreactivity can occur in the absence of molecular mimicry...
  52. ncbi Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance
    Kanji Nagahama
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Int Immunol 21:379-91. 2009
    ....
  53. ncbi An investigation to assess the potential of CD25highCD4+ T cells to regulate responses to donor alloantigens in clinically stable renal transplant recipients
    Ahmed Akl
    Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
    Transpl Int 21:65-73. 2008
    ....
  54. ncbi Regulatory cells in transplantation
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Novartis Found Symp 252:177-88; discussion 188-93, 203-10. 2003
    ....
  55. ncbi Investigation of peptide involvement in T cell allorecognition using recombinant HLA class I multimers
    Alison M E Whitelegg
    The Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
    J Immunol 175:1706-14. 2005
    ..The results show that these alloreactive populations comprise subsets of T cells, each specific for a self-peptide presented by foreign class I molecules, with no evidence of peptide-independent components...
  56. ncbi Alloantigen affinity and CD4 help determine severity of graft-versus-host disease mediated by CD8 donor T cells
    Xue Zhong Yu
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 176:3383-90. 2006
    ..These findings underscore that alloantigen affinity and CD4 help control the fate and pathogenicity of alloreactive CD8+ T cells in vivo...
  57. ncbi Dominant transplantation tolerance impairs CD8+ T cell function but not expansion
    Chun Yen Lin
    Sir William Dunn School of Pathology, University of Oxford, UK
    Nat Immunol 3:1208-13. 2002
    ..These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses...
  58. ncbi Role of CD4+ and CD8+ T cells in allorecognition: lessons from corneal transplantation
    F Boisgerault
    Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 167:1891-9. 2001
    ..Although alloreactive CD8+ T cells are activated via the direct pathway, they are not fully competent and cannot contribute to the rejection unless they receive an additional signal provided by professional APCs in the periphery...
  59. ncbi Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transplantation 83:1459-65. 2007
    ..CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis...
  60. pmc Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells
    Ross S Francis
    Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 41:726-38. 2011
    ....
  61. pmc CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses
    B R Blazar
    Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    J Clin Invest 102:473-82. 1998
    ..T cells had intact responses to antigens not present during tolerization. Tolerance was long lived and not readily reversible in vivo. These data have significant implications for the use of tolerization approaches to prevent human GVHD...
  62. ncbi The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation
    J M Rivas
    Department of Immunology, University of Texas, M D Anderson Cancer Center Houston 77030
    J Leukoc Biol 56:769-75. 1994
    ..Because anti-IL-4 and anti-IL-10 did not block the activity of the UV Ts that regulate contact hypersensitivity, their effects appear to be mediated by a different mechanism...
  63. ncbi CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    Cherry I Kingsley
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Immunol 168:1080-6. 2002
    ..In clinical transplantation, the generation of regulatory T cells that could provide dynamic control of rejection responses is a possible route to permanent graft survival without the need for long-term immunosuppression...
  64. pmc Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:2758-63. 2006
    ..Therefore, alloantigen-selected Tregs are more effective suppressors of responses to major transplantation antigens, and these Tregs can be expanded from a polyclonal repertoire by DCs...
  65. pmc CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens
    Xue Zhong Yu
    Human Immunogenetics Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Invest 113:1624-30. 2004
    ..This study demonstrates that agonistic Ab's specific for the CD28 costimulatory molecule may be used as novel therapeutic agents to abrogate pathogenic T cell responses by selective depletion of activated T cells...
  66. ncbi Regulatory T cells in transplantation
    Mahzuz Karim
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, UK
    Curr Opin Immunol 14:584-91. 2002
    ..Such cells have now been identified in humans as well as in rodents...
  67. ncbi Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survival
    Masanori Abe
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 5:1808-19. 2005
    ..9 days, respectively). Thus, pre-pDC of donor origin have potential to regulate T-cell responses to alloantigens and can prolong organ graft survival...
  68. ncbi Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera
    Steffen Klippel
    Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, and the Department of Hematology and Oncology, University Hospital Freiburg, Germany
    Blood 100:2441-8. 2002
    ..Therefore, quantification of PRV-1 surface expression cannot be used for the diagnosis of polycythemia vera...
  69. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004
    ..Their absence led to a failure of gestation due to immunological rejection of the fetus...
  70. ncbi Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process
    Mahzuz Karim
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Immunol 172:923-8. 2004
    ..These observations may have important implications for the design of protocols, both experimental and clinical, for the induction of tolerance to autoantigens or alloantigens in adults with limited thymic function...
  71. pmc IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    Birgit Sawitzki
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, England, UK
    J Exp Med 201:1925-35. 2005
    ..These data support a unique role for IFN-gamma in the functional activity of alloantigen-reactive T reg cells during the development of operational tolerance to donor alloantigens in vivo...
  72. ncbi CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 174:7573-83. 2005
    ..Summarizing, the described procedure enables induction, expansion, and especially selection of highly suppressive, Ag-specific Treg subsets, which are crucial in Ag-specific, Treg-based immunotherapy...
  73. ncbi The complementary roles of deletion and regulation in transplantation tolerance
    Robert I Lechler
    Department of Immunology, Division of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, Commonwealth Building, Du Cane Road, London W12 0NN, UK
    Nat Rev Immunol 3:147-58. 2003
    ..This review outlines our current understanding of the mechanisms of allograft tolerance, emphasizing the complementary roles of deletion and regulation of alloreactive T cells...
  74. ncbi Detection of alloreactive T cells by flow cytometry: a new test compared with limiting dilution assay
    Aalzen de Haan
    Medical Biology Section of Pathology and Laboratory Medicine, Groningen, The Netherlands
    Transplantation 74:562-70. 2002
    ..To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared these frequencies with classical LDA estimates of frequencies...
  75. ncbi CD4+CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients
    David S Game
    Department of Immunology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    J Am Soc Nephrol 14:1652-61. 2003
    ..It is concluded that the action of CD4(+)CD25(+) regulatory cells is not the main mechanism of donor-specific hyporesponsiveness in the direct pathway of allorecognition...
  76. ncbi A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA
    H Havelková
    Institute of Molecular Genetics, Academy of Sciences, Czech Republic, Fleming nám 2, 166 37 Prague 6, Czech Republic
    Genes Immun 1:483-7. 2000
    ....
  77. ncbi Human vascular endothelial cells stimulate a lower frequency of alloreactive CD8+ pre-CTL and induce less clonal expansion than matching B lymphoblastoid cells: development of a novel limiting dilution analysis method based on CFSE labeling of lymphocytes
    T J Dengler
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 166:3846-54. 2001
    ....
  78. ncbi Tolerogenic response: allorecognition pathways
    A Caballero
    Servicio de Inmunologia, Hospital Regional Universitario Carlos Haya, 29010 Malaga, Spain
    Transpl Immunol 17:3-6. 2006
    ..Nonetheless, a number of studies are only fully understood when a third proposed allorecognition mechanism is taken into account. This is the semi-indirect pathway, as discussed in this short report...
  79. ncbi Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question
    E J Suchin
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 166:973-81. 2001
    ..Bystander proliferation is negligible, revealing exquisite specificity to the alloresponse. These data provide a novel approach to quantify alloreactive T cell responses during specific immunomodulatory strategies in vivo...
  80. ncbi Trafficking of host- and donor-derived dendritic cells in rat cardiac transplantation: allosensitization in the spleen and hepatic nodes
    T Saiki
    Department of Anatomy I, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan
    Transplantation 71:1806-15. 2001
    ....
  81. ncbi Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Nat Rev Immunol 7:585-98. 2007
    ....
  82. ncbi Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice
    G Benichou
    Department of Surgery, University of California, San Francisco 94114, USA
    J Immunol 162:352-8. 1999
    ..This work provides a new approach for analysis of the immunophysiology of allograft rejection and should be useful for monitoring immune responses to graft Ags in human transplant recipients...
  83. ncbi Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice
    Z Dai
    The Carlos and Marguerite Mason Transplantation Research Center, Emory University and Veterans Affairs Medical Center, Atlanta, GA 30033, USA
    J Immunol 161:1659-63. 1998
    ..These findings indicate that endogenous IL-2 is required for the induction of long-term allograft survival, and that IL-2 regulates alloimmune responses by preparing activated T lymphocytes for alloantigen-induced apoptosis...
  84. ncbi Allogeneic stimulation of naturally occurring CD4+CD25+ T cells induces strong regulatory capacity with increased donor-reactivity
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Transpl Immunol 17:237-42. 2007
    ..We propose that selectively favoring the effects of alloreactive T(REG) is a pivotal element in inducing graft acceptance...
  85. pmc Murine Ly-6 multigene family is located on chromosome 15
    K P LeClair
    Proc Natl Acad Sci U S A 84:1638-42. 1987
    ..The possible involvement of the Ly-6 lymphocyte activation and differentiation antigen genes in chromosome 15-related lymphoid malignancies is discussed...
  86. ncbi T-cell allorecognition: a case of mistaken identity or déjà vu?
    Julia K Archbold
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Trends Immunol 29:220-6. 2008
    ....
  87. pmc Characterization of intraocular immunopathology following intracameral inoculation with alloantigen
    Daniel R Saban
    Department of Pathology, University of Florida, Gainesville, FL, USA
    Mol Vis 14:615-24. 2008
    ..Thus, the current study was undertaken to detect and characterize potential pathological effects on intraocular tissues following intracameral inoculation with alloantigen...
  88. ncbi Granulocyte antigens and antibody detection
    D Stroncek
    Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Maryland, USA
    Vox Sang 87:91-4. 2004
  89. pmc A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity
    M D Tallquist
    Department of Immunology, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Exp Med 184:1017-26. 1996
    ..The endogenous protein, MLRQ, contains a peptide sequence identical to dEV-8. This degenerate recognition of two distinct peptide/MHC complexes by a single TCR has important implications for understanding allorecognition...
  90. ncbi Monoclonal antibody GB24 recognizes a trophoblast-lymphocyte cross-reactive antigen
    B L Hsi
    INSERM U210, , Nice, France
    Am J Reprod Immunol Microbiol 18:21-7. 1988
    ..Microvilli from different placentae revealed substantial differences regarding the intensity of the labeling of these two bands, suggesting that the antigens recognized by GB24 are probably allotypic...
  91. pmc Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy
    Jorieke H Peters
    Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e2233. 2008
    ..For the human setting, information is lacking on how to generate Treg with direct antigen-specificity ex vivo to be used for immunotherapy...
  92. ncbi Human neutrophil antigen-4a gene frequencies in an Australian population, determined by a new polymerase chain reaction method using sequence-specific primers
    H D Clague
    Queensland Institute of Medical Research, Australian Red Cross Blood Service, Brisbane, Queensland, Australia
    Transfus Med 13:149-52. 2003
    ..The gene frequency was found to be 0.906, which is the same as in the American population. The PCR-SSP genotyping method perfectly correlates with serological phenotyping and is efficient for screening large numbers of samples...
  93. ncbi Platelet and granulocyte glycoprotein polymorphisms
    G F Lucas
    International Blood Group Reference Laboratory, Bristol, UK
    Transfus Med 10:157-74. 2000
  94. ncbi Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies
    Akhil Maheshwari
    Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine and All Children s Hospital, St Petersburg, Florida 33701, USA
    Pediatrics 109:e64. 2002
    ....
  95. ncbi Neutrophil alloantigens
    David Stroncek
    Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892 1184, USA
    Transfus Med Rev 16:67-75. 2002
    ..New polymorphisms in these antigen systems are still being described, but the complete understanding of these neutrophil antigen systems has been slow because of the complexity of these genes...
  96. ncbi The risk of antibody formation against HNA1a and HNA1b granulocyte antigens during pregnancy and its relation to neonatal neutropenia
    B Zupanska
    Department of Immunohaematology and Immunology of Transfusion Medicine, Institute of Haematology and Blood Transfusion, 5 Chocimska Str, 00 957 Warsaw, Poland
    Transfus Med 11:377-82. 2001
    ..A comparison with our previous, unpublished data suggests that the incidence of severe NAIN is roughly 1 per 6000 (four cases among 24101 newborns)...
  97. ncbi CD3+CD4-CD8- alphabeta-TCR+ T cell as immune regulatory cell
    Z X Zhang
    Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2 815, Toronto, M5A 1E7, Canada
    J Mol Med (Berl) 79:419-27. 2001
    ....
  98. pmc Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis
    Tarek El-Sawy
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 165:147-57. 2004
    ..These data demonstrate CD8+ T cell-mediated attack on the vascular endothelium of allografts within hours following organ reperfusion that amplifies innate immune-mediated intra-graft inflammation and necrosis...
  99. pmc Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease
    Erin E West
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Respir Cell Mol Biol 34:108-18. 2006
    ....
  100. ncbi Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC
    Tara M Strutt
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Int Immunol 18:719-28. 2006
    ..These different requirements for activation could reflect the fact that thymocytes have not received an exit-thymus signal and/or that splenic T cells are heterogeneous, containing naive, memory and partially-activated T cells...
  101. ncbi Dipeptide boronic acid, a novel proteasome inhibitor, prevents islet-allograft rejection
    Yulian Wu
    Laboratory of Immunology, Centre hospitalier de l Universite de Montreal CHUM Notre Dame Hospital, Montreal, Quebec, Canada
    Transplantation 78:360-6. 2004
    ..This implies that they could be used as a novel category of immunosuppressants to block allograft rejection. Therefore, in this study, dipeptide boronic acid (DPBA) was tested for its effect on mouse islet transplantation...

Research Grants63

  1. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..The proposed studies will definitely evaluate the efficacy and mechanisms of TCN in controlling GVHD in clinically relevant models of BMT, and may point to a novel and more selective strategy to prevent GVHD in the clinic. ..
  2. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2013
    ....
  3. Definition of an Ancient T cell-like System in Lampreys
    MAX DALE COOPER; Fiscal Year: 2013
    ..Candidate histocompatibility genes will be examined for genetic polymorphism, expression patterns and immunostimulatory potential. ..
  4. VIRAL INFECTION INFLUENCE ON TRANSPLANTATION TOLERANCE
    DALE LESLIE GREINER; Fiscal Year: 2013
    ..This work will identify how infection during transplantation may affect the host immune system and ultimate fate of the graft. ..
  5. The role of tolerogenic dendritic cells in islet-cell allograft transplantation
    SHERRIE JILL DIVITO; Fiscal Year: 2010
    ..Therefore, the development of cellular based therapies that prolong islet-cell transplant survival by inducing donor-specific tolerance without side effects is clearly advantageous. ..
  6. NK and T Cell Regulation of ES-Derived Hematopoietic Progenitor Cell Engraftment
    WILLIAM TABAYOYONG; Fiscal Year: 2010
    ..When completed, these studies will provide a characterization of the immune response directed against transplanted ES-derived HPC and may provide further insight into the immunobiology of other ES-derived cellular therapies. ..
  7. Molecular pathogenesis of anti-glomerular basement membrane nephritis
    Dorin Bogdan Borza; Fiscal Year: 2012
    ..These studies may identify factors that increase the risk of disease, suggest how to avoid disease in people at risk, and yield better treatments of established disease. ..
  8. Post-Transplant Inflammatory Response
    Robert L Fairchild; Fiscal Year: 2012
    ....
  9. Novel Therapies for Chronic Renal Allograft Dysfunction in Children
    William E Harmon; Fiscal Year: 2012
    ..The main goal of these studies is to understand the mechanisms of action of belatacept/AEB071 and to develop a set of surrogate biomarkers of chronic allograft dysfunction and stability in pediatric kidney transplant recipients. ..
  10. DC-ASGPR AS A NOVEL TARGET FOR CONTROLLING GVHD AND ALLOGRAFT REJECTION
    SangKon Oh; Fiscal Year: 2013
    ..More importantly, data generated from this study will support humanization of our novel antibody for the rational design and development of novel immunotherapeutics for patients who undergo transplantation in the near future. ..
  11. Consequences of Aging on Immune Response and Transplant Outcome
    STEFAN GUNTHER TULLIUS; Fiscal Year: 2013
    ..Therefore, this study is important because it is novel and it will permit us to develop effective and new therapies to prevent allograft rejection in elderly patients. ..
  12. Presentation of Alloantigen by Human Vascular Cells
    Jordan S Pober; Fiscal Year: 2013
    ..This characterization of EC presentation of alloantigen can lead to new strategies to reduce organ rejection in the clinic which remains as a major cause of allograft failure. ..
  13. "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation"
    Qizhi Tang; Fiscal Year: 2013
    ..It is strongly aligned with NIAID's goal to "evaluate approaches that include tolerogenic, anti-inflammatory, and immunomodulatory strategies to treat and prevent immune-mediated diseases". ..
  14. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..Our studies have major implications for improving outcomes of solid organ transplant recipients. ..
  15. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2013
    ....
  16. Migration and Trafficking in Tolerance 10/07
    Jonathan S Bromberg; Fiscal Year: 2012
    ..The ability to define these interactions and achieve tolerance is important for achieving good graft survival and patient survival for transplant recipients. ..
  17. Induction and Migration of Regulatory T Cells
    Jonathan S Bromberg; Fiscal Year: 2013
    ..The ability to define these interactions and achieve tolerance is important for achieving good graft survival and patient survival for transplant recipients. ..
  18. Role of T cell Specific Adaptor Protein in Alloimmunity
    David M Briscoe; Fiscal Year: 2012
    ....
  19. Activation of the alloimmune response
    Jagdeep S Obhrai; Fiscal Year: 2012
    ..The Center brings together investigators with diverse expertise who are focused on the science of transplantation to improve the lives of transplant recipients. ..
  20. Signals Affecting Homestasis and Tolerance in Memory T Cells
    Jonathan S Maltzman; Fiscal Year: 2013
    ..We propose to define and dissect the effect of infection on homeostasis of memory T cells and transplantation by combining viral infection models with conditional gene deletion and studies on transplantation tolerance. ..
  21. ANERGY, APOPTOSIS AND CD28 IN CD8+ T CELLS DURING AIDS
    Dorothy E Lewis; Fiscal Year: 2010
    ..Because CD8+ T cells are important for HIV control, these studies are important for development of immune intervention strategies and for vaccine design. ..
  22. Transfusion-associated immune hemolysis
    Karina Yazdanbakhsh; Fiscal Year: 2010
    ..In our grant application, we will expand our animal studies to focus on the triggers that make immune cells accept or reject transfused blood. ..
  23. A Randomized Trial of Tac/MTX/bortezomib vs Tac/MTXplacebo in Allogeneic HSCT
    Joseph H Antin; Fiscal Year: 2013
    ..It will also shed important light on the pathophysiology of GVHD that can be applied to future studies. ..
  24. Alloantigen Delivery Via ECDI-Fixed Cells For Tolerance To Monkey Islet Grafts
    Stephen D Miller; Fiscal Year: 2013
    ..The proposed studies will provide novel insights into the role of ADEC and concomitant immunotherapy for tolerance induction to islet allografts, a critical step toward clinical translaton of this antigen-specific tolerance strategy. ..
  25. Adoptive Transfer of Donor Tregs Specific Against Host Alloantigens for Presentio
    Claudio Anasetti; Fiscal Year: 2013
    ..By trace-labeling the Tregs, we will also assess Treg repopulation and survival after adoptive transfer to allograft recipients. ..
  26. Lymphoid Structure in Tolerance
    Jonathan S Bromberg; Fiscal Year: 2010
    ....
  27. Characterization of Tau Lymphocyte Modulation in Pregnancy
    LEELA E NORONHA; Fiscal Year: 2010
    ..Furthermore, the immunological concepts surrounding this process are also relevant to the fields of transplantation biology, cancer, and infectious diseases. ..
  28. B-Lymphocyte Repertoire Remodeling for Transplantation Tolerance
    Hooman Noorchashm; Fiscal Year: 2010
    ..In this application, we propose a novel avenue of investigations into the possiblity of inducing donor specific immunological tolerance to allografts by targeting recipient B- lymphocytes. ..
  29. Alemtuzumab and Regulatory T Cells for Heart Transplant Tolerance in Monkeys
    Angus W Thomson; Fiscal Year: 2013
    ..abstract_text> ..
  30. Alloreactive Regulatory T cells control GVHD and maintain GVL effect
    Xue Zhong Yu; Fiscal Year: 2013
    ....
  31. Lymphoid Structure in Tolerance: Role of Stromal Cells
    Jonathan S Bromberg; Fiscal Year: 2012
    ....
  32. CMV-Specific CD8+ T Cell Responses in Kidney Transplant Recipients
    LAURA L GIBSON; Fiscal Year: 2010
    ..These studies will contribute new knowledge to aid in the rational development of effective CMV prevention and treatment strategies for populations at risk for severe CMV disease. ..
  33. Innate Recognition of Allogeneic Non-Self
    Fadi G Lakkis; Fiscal Year: 2013
    ..abstract_text> ..
  34. CXCL9 influences effector T cell priming to cardiac allografts
    Joshua M Rosenblum; Fiscal Year: 2010
    ....
  35. Genomics of Chronic Renal Allograft Rejection
    Barbara T Murphy; Fiscal Year: 2012
    ..The results of these studies will lend greater insight to the underlying mechanisms leading to chronic rejection and help differentiate one cause of CAN. ..
  36. IMMUNOGENETICS OF MARROW ALLOGRAFTING
    John Hansen; Fiscal Year: 1992
    ..The research question addressed in Project 6 is whether the microvariants defined by individual HLA alleles have a significant impact on GVHD...
  37. PRESERVATION AND CARDIAC TRANSPLANT VASCULOPATHY
    David Pinsky; Fiscal Year: 2003
    ..These experiments will provide new insights into mechanisms by which early ischemic injury leads to early graft failure and TCAD, and proffer new strategies for prevention. ..
  38. NOVEL COFACTOR ANALOGUES AS IMMUNOSUPPRESSANTS
    Krzysztof Pankiewicz; Fiscal Year: 2000
    ..However, its clinical use is limited due to undesirable metabolism. Certainly, new and specific inhibitors of IMPDH are expected to be of great therapeutic interest and commercial potential. ..
  39. PRECLINICAL BRIDGE TO HUMAN TRANSPLANT TOLERANCE
    Judith Thomas; Fiscal Year: 2000
    ..The information gained in these studies is expected to guide successful application of tolerance induction to human transplantation. ..
  40. Immunopathogenesis of Chronic Allograft Rejection
    MOHAMED SAYEGH; Fiscal Year: 2005
    ..abstract_text> ..
  41. Ex Vivo Alloanergization to Improve Immunity After Haploidentical Transplant
    Eva C Guinan; Fiscal Year: 2010
    ..the number of tolerized donor immune cells necessary to improve immune function after mismatched HSCT without contributing to GVHD, and perform laboratory experiments to characterize the mechanisms by which these goals are achieved ..
  42. Movement of Recipient T-Cells Away From an Allograft
    Mark Poznansky; Fiscal Year: 2003
    ....
  43. P-glycoprotein Function in Allograft Rejection
    Markus Frank; Fiscal Year: 2004
    ....
  44. T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETION
    Andrew Mellor; Fiscal Year: 2002
    ....
  45. Phase I Study of BB3 in Dialysis Patients
    Weizhong Cai; Fiscal Year: 2009
    ..The data from these two clinical studies form a solid basis for the Phase II study in renal transplantation. PUBLIC HEALTH RELEVANCE: A small molecule organ protective agent has significant clinical potential in renal transplantation. ..
  46. Role of Host Dendritic Cells in Heart Transplant Vasculopathy
    Zhiliang Wang; Fiscal Year: 2007
    ..We believe the data from the proposal will lead to better understanding of the pathogenesis and therapy of graft chronic rejection. [unreadable] [unreadable]..
  47. STEM CELLS AND ACCESSORY CELLS IN PERIPHERAL BLOOD
    Beverly Torok Storb; Fiscal Year: 2003
    ..Our final goal is to use the G-PBMC product to establish a non-toxic conditioning regimen to achieve stable mixed chimerism in haploidentical donor/recipient pairs. ..
  48. Immunomodulation by MHC Class II Peptides
    Barbara Murphy; Fiscal Year: 2005
    ..These studies will help elucidate the potential role of MHC class II peptides in the prevention of transplant rejection and the induction of tolerance. ..
  49. MOLECULAR IMMUNOLOGY OF MINOR HISTOCOMPATIBILITY ANTIGEN
    Sebastian Joyce; Fiscal Year: 2009
    ..Additionally, the beneficial effects of graft-versus-leukemia, a by-product of GvHD, can be utilised as a therapy against cancers. ..
  50. Effector Mechanisms in Graft Tolerance
    Randolph J Noelle; Fiscal Year: 2010
    ..New evidence strongly implicates IL-9 and mast cells as elements that may be important to peripheral tolerance, and studies are presented to functionally implicate their involvement. ..
  51. Induction of T Cell Chemoattractants in Acute Rejection
    Robert Fairchild; Fiscal Year: 2007
    ..abstract_text> ..
  52. TRANSPLANTATION TOLERANCE :T CELL TRAFFICKING
    Jonathan Bromberg; Fiscal Year: 2001
    ..2) Determine what other receptors and ligands are important for lymph node localization and tolerance induction. 3) Determine the role of other cells and anatomic sites during tolerance induction. ..
  53. IMMUNE MECHANISMS OF CHRONIC ALLOGRAFT REJECTION
    Charles Carpenter; Fiscal Year: 2000
    ..The above studies should provide relevant information for development of novel strategies to prevent and possibly interrupt chronic allograft rejection in clinical transplantation. ..
  54. T Cells in the Pathogenesis of Systemic Sclerosis
    Chris Platsoucas; Fiscal Year: 2005
    ..d. To identify Thl, Th2, suppressor, anergic and CTL T-cell clones from those developed above, on the basis of expression patterns of their genes, using DNA array technology. ..
  55. BLOOD GROUP ANTIGENS AND ANTIBODIES
    JAMES MOHN; Fiscal Year: 1980
    ..The major approach focuses on the fundamental immunologic characteristics of human blood group isoantigens and antibodies in attempts to determine the structural basis for immunologic specificity and to relate their ..
  56. MODELING OF PLATELET ALLOANTIGENS
    Emily Barron Casella; Fiscal Year: 2002
    ..The ability of HPA-1a murine GPIIIa to assemble into a fibrinogen receptor and bind ligand in transfected megakaryoblastic cells will also be tested. ..
  57. CYTOTOXIC CELLS AND ALLOIMMUNE RESPONSES
    Dwain Thiele; Fiscal Year: 2002
    ..These studies should provide new insights into the regulation of CTL effector mechanisms and the role that such effector mechanisms play in complications of bone marrow and organ transplantation. ..
  58. VASCULAR DISEASE IN HUMAN HEART TRANSPLANTATION
    Geraldine Miller; Fiscal Year: 2003
    ..These studies will enhance our understanding of the factors within allograft environments that, together with antigen recognition, lead to T cell activation and survival and the translation of these events to CAV. ..
  59. CYTOKINES AND LIVER TRANSPLANTATION
    OLIVIA MARTINEZ; Fiscal Year: 2003
    ..abstract_text> ..
  60. NON-MHC ANTIGEN ROLE IN RENAL & CARDIAC TRANSPLANTATION
    Thalachallour Mohanakumar; Fiscal Year: 2000
    ....
  61. T CELL ACTIVIATION BY DISTINCT ANTIGEN PRESENTING CELLS
    Seth Stevens; Fiscal Year: 2002
    ..Signaling through VLA-5 is hypothesized to be transduced via the receptor tyrosine kinase, MAP kinase pathway. ..
  62. INTRATHYMIC TRANSPLANTATION TOLERANCE BY MHC PEPTIDES
    MOHAMED SAYEGH; Fiscal Year: 2003
    ..Results from these studies should yield clinically relevant information facilitating development of novel strategies to induce donor-specific tolerance. ..
  63. The CD40-CD154 pathway in chronic allograft rejection
    Anil Chandraker; Fiscal Year: 2005
    ..Understanding the mechanisms of how alloantigen dependent and independent pathways contribute to the overall process may provide novel therapeutic approaches for modulating the effects of chronic allograft rejection. ..