fungal antigens

Summary

Summary: Substances of fungal origin that have antigenic activity.

Top Publications

  1. pmc Well-characterized monoclonal antibodies against cell wall antigen of Aspergillus species improve immunoassay specificity and sensitivity
    Wei Hao
    Center of Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, China
    Clin Vaccine Immunol 15:194-202. 2008
  2. ncbi Fungal vaccines: real progress from real challenges
    Antonio Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet Infect Dis 8:114-24. 2008
  3. ncbi Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis
    G Benard
    Laboratório de Alergia e Imunologia Clínica e Experimental, LIM 56, Faculdade de Medicina da Universidade de Sao Paulo FMUSP, Sao Paulo, Brazil
    Cytokine 13:248-52. 2001
  4. pmc Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    Cindy S Ma
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst 2010, Australia
    J Exp Med 205:1551-7. 2008
  5. ncbi Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies
    Holger Hebart
    Department of Hematology and Oncology, Institute for Medical Information Processing, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Blood 100:4521-8. 2002
  6. ncbi Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses
    Aida Pitarch
    Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
    Mol Cell Proteomics 5:79-96. 2006
  7. pmc Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification
    Suhail Ahmad
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    J Clin Microbiol 40:2483-9. 2002
  8. ncbi Binding of extracellular matrix proteins to Paracoccidioides brasiliensis
    Maria José Soares Mendes-Giannini
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, UNESP, R Expedicionários do Brasil, 1621, 14802 901 Araraquara São Paulo, Brazil
    Microbes Infect 8:1550-9. 2006
  9. ncbi Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:2603-11. 2000
  10. ncbi Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:1832-42. 2001

Detail Information

Publications257 found, 100 shown here

  1. pmc Well-characterized monoclonal antibodies against cell wall antigen of Aspergillus species improve immunoassay specificity and sensitivity
    Wei Hao
    Center of Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, China
    Clin Vaccine Immunol 15:194-202. 2008
    ....
  2. ncbi Fungal vaccines: real progress from real challenges
    Antonio Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet Infect Dis 8:114-24. 2008
    ..Together with the demonstrated efficacy of various antibodies in passive vaccination approaches, there is growing confidence in the future availability of safe and efficacious immunological tools to combat deadly microbes in a weak host...
  3. ncbi Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis
    G Benard
    Laboratório de Alergia e Imunologia Clínica e Experimental, LIM 56, Faculdade de Medicina da Universidade de Sao Paulo FMUSP, Sao Paulo, Brazil
    Cytokine 13:248-52. 2001
    ..Our results suggest that the imbalance in cytokine production of patients with PCM plays a role in the gp43-hyporesponsiveness and the marked (non-protective) antibody production of these patients...
  4. pmc Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    Cindy S Ma
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst 2010, Australia
    J Exp Med 205:1551-7. 2008
    ..Because Th17 cells are enriched for cells with specificities against fungal antigens, our results may explain the pattern of infection susceptibility characteristic of patients with HIES...
  5. ncbi Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies
    Holger Hebart
    Department of Hematology and Oncology, Institute for Medical Information Processing, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Blood 100:4521-8. 2002
    ..In conclusion, these results further support the hypothesis that T cells contribute to the host defense against A fumigatus...
  6. ncbi Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses
    Aida Pitarch
    Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
    Mol Cell Proteomics 5:79-96. 2006
    ..Furthermore serum anti-wall enolase antibodies are a new prognostic indicator for SC and confer protection against it. Bgl2p and wall-associated enolase could be valuable candidates for future vaccine development...
  7. pmc Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification
    Suhail Ahmad
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    J Clin Microbiol 40:2483-9. 2002
    ..Moreover, the improved detection of cases of candidemia caused by more than one Candida species is an additional advantage...
  8. ncbi Binding of extracellular matrix proteins to Paracoccidioides brasiliensis
    Maria José Soares Mendes-Giannini
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, UNESP, R Expedicionários do Brasil, 1621, 14802 901 Araraquara São Paulo, Brazil
    Microbes Infect 8:1550-9. 2006
    ..In conclusion, this work provided new molecular details on the interaction between P. brasiliensis and ECM components...
  9. ncbi Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:2603-11. 2000
    ..Thus, these findings demonstrate that CCR2 plays an important role in the immune response against A. fumigatus, thereby limiting the allergic airway inflammatory and remodeling responses to this fungus...
  10. ncbi Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:1832-42. 2001
    ..These data suggest that MCP-1/CCL2 participates in the pulmonary antifungal and allergic responses to A. fumigatus conidia...
  11. ncbi The physical properties of the capsular polysaccharides from Cryptococcus neoformans suggest features for capsule construction
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 281:1868-75. 2006
    ..A mechanism for capsule growth is proposed based on the extracellular release and entanglement of GXM molecules...
  12. ncbi Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
    Marta Stanzani
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3 3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
    Blood 105:2258-65. 2005
    ..These studies suggest that the production of gliotoxin by AF may constitute an important immunoevasive mechanism that is mediated by direct effects on antigen-presenting cells and both direct and indirect effects on T cells...
  13. pmc Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 98:10422-7. 2001
    ..Thus, a C. neoformans mannoprotein has been characterized that stimulates T cell responses and has molecular properties of a chitin deacetylase...
  14. ncbi Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls
    Sara J Oliveira
    Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas Medical School, PO Box 6111, 13083 970, SP, Campinas, Brazil
    Microbes Infect 4:139-44. 2002
    ..Since AF patients are able to control fungal dissemination for decades, they can be considered more resistant than JF patients, who manifest the disease soon after infection...
  15. ncbi The 43-kDa glycoprotein from the human pathogen Paracoccidioides brasiliensis and its deglycosylated form: excretion and susceptibility to proteolysis
    R Puccia
    Disciplina de Biologia Celular, Escola Paulista de Medicina, , Brazil
    Arch Biochem Biophys 289:298-302. 1991
    ..The present results provide a basis for the understanding of diagnostic reactions and fungal virulence involving the gp43 exocellular antigen of P. brasiliensis...
  16. ncbi Contribution of glycosylation to T cell responses stimulated by recombinant Cryptococcus neoformans mannoprotein
    Charles A Specht
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Infect Dis 196:796-800. 2007
    ..Thus, mannosylation is critical for optimal T cell responses to a fungal antigen and should be taken into account when vaccines to protect against mycoses are designed...
  17. ncbi Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma
    K Blease
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:5219-24. 2001
    ..Therefore, IL-13 provides an attractive therapeutic target in allergic asthma...
  18. pmc Current status of nonculture methods for diagnosis of invasive fungal infections
    Siew Fah Yeo
    Infectious Disease Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Microbiol Rev 15:465-84. 2002
    ..These approaches include detection of specific host immune responses to fungal antigens, detection of specific macromolecular antigens using immunologic reagents, amplification and detection of ..
  19. pmc Identification of continuous B-cell epitopes on the protein moiety of the 58-kiloDalton cell wall mannoprotein of Candida albicans belonging to a family of immunodominant fungal antigens
    A Viudes
    Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Infect Immun 69:2909-19. 2001
    ..It belongs to a family of immunodominant fungal antigens with representatives also in different species of Aspergillus...
  20. ncbi Production of hybrid phage displaying secreted aspartyl proteinase epitope of Candida albicans and its application for the diagnosis of disseminated candidiasis
    Qiong Yang
    Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University, Changchun City, Jilin Province, People s Republic of China
    Mycoses 50:165-71. 2007
    ..These data indicate this phage-displayed epitope as an effective and less expensive reagent would be a valuable probe for the detection of specific Sap antibody in the sera of patients and mice with systemic C. albicans infection...
  21. pmc Diagnosis of invasive candidiasis by enzyme-linked immunosorbent assay using the N-terminal fragment of Candida albicans hyphal wall protein 1
    Ana Laín
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Spain
    BMC Microbiol 7:35. 2007
    ..In the last decade, much effort has been made to develop reliable tests for rapid diagnosis of invasive candidiasis, but none of them have found widespread clinical use...
  22. ncbi Peripheral blood mononuclear cells from allergic fungal rhinosinusitis adults express a Th2 cytokine response to fungal antigens
    Amber Luong
    Department of Otorhinolaryngology Head and Neck Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Am J Rhinol Allergy 23:281-7. 2009
    ..Initially thought to represent an immunoglobulin E (IgE)-mediated hypersensitivity to fungal antigens, additional data have implicated other non-IgE and cellular-mediated pathways...
  23. ncbi Diagnosis of histoplasmosis by antigen detection based upon experience at the histoplasmosis reference laboratory
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis, IN, USA
    Diagn Microbiol Infect Dis 43:29-37. 2002
    ..This report is based soley upon the experience at the Histoplasmosis Reference Laboratory, and can not be used in interpretation of results of Histoplasma antigen testing done at other laboratories...
  24. ncbi Isolation of Paracoccidioides brasiliensis from armadillos (Dasypus novemcinctus) in an area where the fungus was recently isolated from soil
    M L Silva-Vergara
    Faculdade de Medicina do Triangulo Mineiro, Uberaba, Brazil
    Med Mycol 38:193-9. 2000
    ....
  25. ncbi Immunogenicity and protective effect of recombinant enolase of Candida albicans in a murine model of systemic candidiasis
    Claudia Montagnoli
    Laboratory of Bacteriology and Medical Mycology Istituto Superiore di Sanità, Rome, Italy
    Med Mycol 42:319-24. 2004
    ....
  26. ncbi Canine paracoccidioidomycosis
    G Ricci
    Department of Pathology, Federal University of Sao Paulo UNIFESP EPM, Sao Paulo, Brazil
    Med Mycol 42:379-83. 2004
    ..This is the first report of PCM disease occurring in a dog, an animal that has been shown to play an important role in the natural history of North American blastomycosis...
  27. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003
    ....
  28. ncbi Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells
    Michael K Mansour
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 176:3053-61. 2006
    ..These data suggest that DC provide the crucial link between innate and adaptive immune responses to C. neoformans via a process that is dependent upon the efficient uptake of mannoprotein by mannose receptors...
  29. pmc Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis
    Robert A Larsen
    Department of Medicine Infectious Diseases, 2020 Zonal Ave, IRD Room 632, MC 9520, University of Southern California, Los Angeles, CA 90033, USA
    Antimicrob Agents Chemother 49:952-8. 2005
    ..The half-life of MAb 18B7 in serum was approximately 53 h, while the MAb was undetectable in the cerebrospinal fluid of all patients. These data support the continued investigation of MAb 18B7 at a maximum single dose of 1.0 mg/kg...
  30. ncbi Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies
    Aida Pitarch
    Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Proteomics 4:3084-106. 2004
    ..This approach could therefore provide new challenges for diagnosis and clinical follow-up of these fungal infections, and even for antifungal drug or vaccine design...
  31. pmc Advances in combating fungal diseases: vaccines on the threshold
    Jim E Cutler
    Department of Pediatrics and Microbiology, Louisiana State University Health Sciences, and Research Institute for Children at Children s Hospital, New Orleans, Louisiana, 70118 USA
    Nat Rev Microbiol 5:13-28. 2007
    ....
  32. ncbi Polysaccharides, mimotopes and vaccines for fungal and encapsulated pathogens
    L A Pirofski
    Divn of Infectious Diseases, Room 709 Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Trends Microbiol 9:445-51. 2001
    ..neoformans in mice, however, our knowledge of the mechanisms of mimotope-induced protection is incomplete and further work is needed if polysaccharide- or mimotope-based vaccines are to be used to manage C. neoformans infection...
  33. pmc The monoclonal antibody against the major diagnostic antigen of Paracoccidioides brasiliensis mediates immune protection in infected BALB/c mice challenged intratracheally with the fungus
    R Buissa-Filho
    Institute of Biomedical Sciences, Department of Microbiology, University of Sao Paulo, Ave Prof Lineu Prestes, Sao Paulo, SP 05508 900, Brazil
    Infect Immun 76:3321-8. 2008
    ..The present work shows that some but not all MAbs against gp43 can reduce the fungal burden and identifies a new peptide candidate for vaccine development...
  34. ncbi Diversity in Paracoccidioides brasiliensis. The PbGP43 gene as a genetic marker
    Rosana Puccia
    Cell Biology Division, Federal University of Sao Paulo, UNIFESP, Rua Botucatu, 862, oitavo andar, Sao Paulo, SP 04023 062, Brazil
    Mycopathologia 165:275-87. 2008
    ..Fungal traits associated with genetic groups are discussed...
  35. ncbi Unexpected diversity in the fine specificity of monoclonal antibodies that use the same V region gene to glucuronoxylomannan of Cryptococcus neoformans
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 172:3670-7. 2004
    ....
  36. ncbi Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy
    L Tramsen
    Pediatric Hematology and Oncology, Children s Hospital III, Johann Wolfgang Goethe University, Frankfurt, Germany
    Bone Marrow Transplant 43:13-9. 2009
    ..This method of generating is suitable for future prospective trials designed to evaluate the effect of adoptive immunotherapy in hematopoietic transplant recipients with invasive aspergillosis...
  37. pmc Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90
    Ruth C Matthews
    Department of Medical Microbiology, University of Manchester, Manchester M13 9WL, United Kingdom
    Antimicrob Agents Chemother 47:2208-16. 2003
    ..albicans (kidney), C. krusei (spleen), C. glabrata (spleen), and C. parapsilosis (liver and spleen). Only by combining Mycograb with AMB was complete resolution of infection achieved for C. albicans, C. krusei, and C. glabrata...
  38. ncbi Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis
    Alexandre F Marques
    Institute of Biomedical Sciences, Department of Microbiology, University of Sao Paulo, Sao Paulo, SP, Brazil
    Microbes Infect 10:1251-8. 2008
    ..Results recommend that a P10-based vaccine should be associated to chemotherapy for improved treatment of paracoccidioidomycosis aiming especially at anergic cases...
  39. pmc Antigen assay with the potential to aid in diagnosis of blastomycosis
    Michelle Durkin
    MiraVista Diagnostics MiraBella Technologies, Indianapolis, Indiana 46241, USA
    J Clin Microbiol 42:4873-5. 2004
    ..9% of patients with cryptococcosis, and 1.1% of patients with aspergillosis. Reproducibility was 96.3%. These findings support a potential role for antigen testing in blastomycosis...
  40. ncbi Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype
    Marcela Torres
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:2132-42. 2005
    ..Given that isotype class switching and Ig gene somatic hypermutation share molecular mechanisms, these observations unify these processes in the sense that both can alter specificity and affinity...
  41. ncbi A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity
    Jennifer S Lam
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, MA 02118, USA
    J Immunol 175:7496-503. 2005
    ..These data have implications for vaccine design by providing proof of principle that yeast-derived mannosylation can enhance immunogenicity...
  42. ncbi [Evaluation of a new commercial test (Candida albicans IFA IgG) for the serodiagnosis of invasive candidiasis]
    María Dolores Moragues
    Departamento de Enfermería I, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Espana
    Enferm Infecc Microbiol Clin 22:83-8. 2004
    ....
  43. pmc Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey
    Mahmoud Zureik
    European Community Respiratory Health Survey, Unit 408 Epidémiologie, Faculte de Medecine Xavier Bichat, BP 416, 75870 Paris Cedex 18, France
    BMJ 325:411-4. 2002
    ..To assess whether the severity of asthma is associated with sensitisation to airborne moulds rather than to other seasonal or perennial allergens...
  44. ncbi Immunization of susceptible mice with gp43-pulsed dendritic cells induce an increase of pulmonary Paracoccidioidomycosis
    Karen Spadari Ferreira
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Avenida Prof Lineu Prestes, 580, Bloco 17, Sao Paulo, CEP 05508 900, Brazil
    Immunol Lett 103:121-6. 2006
    ....
  45. ncbi Virulence of Paracoccidioides brasiliensis and gp43 expression in isolates bearing known PbGP43 genotype
    Kátia C Carvalho
    Departamento de Microbiologia, Imunologia e Parasitologia, Disciplina de Biologia Celular, UNIFESP, Rua Botucatu, 862, oitavo andar, Sao Paulo, SP 04023 062, Brazil
    Microbes Infect 7:55-65. 2005
    ..We present the first evidence of transcriptional regulation of gp43 expression, but our results suggest that gene expression is also regulated at the protein and/or secretion levels...
  46. pmc Immunobiological activity of recombinant H antigen from Histoplasma capsulatum
    G S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio 45267 0560, USA
    Infect Immun 63:3151-7. 1995
    ..Mice inoculated with H antigen were not protected against either a sublethal or a lethal inoculum of yeast cells. Thus, H antigen stimulates a cell-mediated immune response but does not induce a protective response to H. capsulatum...
  47. pmc Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
    Marcio L Rodrigues
    Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 590, Brazil
    Clin Vaccine Immunol 14:1372-6. 2007
    ..neoformans, revealing a potential therapeutic strategy to control cryptococcosis...
  48. ncbi Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies
    Olivier Adam
    Pole Microbiologie et Maladies Infectieuses, Institut Gustave Roussy, Villejuif, France
    Clin Infect Dis 38:917-20. 2004
    ..When tested for GM antigen, 3 of 4 piperacillin-tazobactam batches had positive results. Physicians should be aware of the possible interference of treatment with piperacillin-tazobactam when interpreting the results of the GM assay...
  49. pmc Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice
    T N Kirkland
    VA San Diego HealthCare System and Departments of Pathology and Medicine, University of California, San Diego, California 92161, USA
    Infect Immun 66:3519-22. 1998
    ..These studies support the continued development of rPRA as a candidate vaccine for prevention of coccidioidomycosis...
  50. ncbi Identification of Candida albicans genes induced during thrush offers insight into pathogenesis
    Shaoji Cheng
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    Mol Microbiol 48:1275-88. 2003
    ....
  51. ncbi [Biological diagnosis of systemic candidiasis: difficulties and future prospects]
    S Anane
    Departement de Parasitologie, Faculte de Medecine de Tunis, 15, Rue Djebel Lakhdar, 1007 La Rabta, Tunisie
    Pathol Biol (Paris) 55:262-72. 2007
    ..The results of tests for the detection of yeast DNA by PCR obtained recently are promising in terms of sensitivity, specificity and identification of species of Candida...
  52. ncbi False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam
    Annie Sulahian
    N Engl J Med 349:2366-7. 2003
  53. ncbi Genes and molecules involved in Aspergillus fumigatus virulence
    Aitor Rementeria
    Departamento Inmunologia, Microbiologia y Parasitologia, Facultad de Ciencia y Tecnologia, Universidad del Pais Vasco, Spain
    Rev Iberoam Micol 22:1-23. 2005
    ..Sequencing of A. fumigatus genome and study of gene expression during their infective process by using DNA microarray and biochips, promises to improve the knowledge of virulence of this fungus...
  54. pmc Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2
    Manuel Vilanova
    Laboratório de Imunologia Mário Arala Chaves, Instituto de Ciencias Biomedicas de Abel Salazar, Largo do Prof Abel Salazar 2, 4099 003 Porto, Portugal
    Immunology 111:334-42. 2004
    ..Taken together, these analyses demonstrate that Sap2 can be successfully used as a vaccination target in systemic candidiasis and reveals the potential immunomodulatory role of Sap2 on C. albicans infection...
  55. ncbi [Diagnosis of systemic Candida infections. Evaluation of serology, molecular biology and D-arabinitol detection]
    W Bar
    Institut für Mikrobiologie und Krankenhaushygiene, Carol Thiem Klinikum, Thiemstrasse 111, D 03048 Cottbus, Germany
    Mycoses 47:32-6. 2004
    ..In conclusion, serological methods (antigen and antibody detection) should only be applied in strictly selected patients. In uncertain cases, the addition of PCR or determination of D-arabinitol/L-arabinitol might be helpful...
  56. ncbi IgE antibody to Aspergillus fumigatus recombinant allergens in cystic fibrosis patients with allergic bronchopulmonary aspergillosis
    A P Knutsen
    Divisions of Allergy and Immunology, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Allergy 59:198-203. 2004
    ....
  57. pmc Fungal antigens expressed during invasive aspergillosis
    Nicole Denikus
    Department of Medical Microbiology, University of Gottingen, Kreuzbergring 57, D 37075 Gottingen, Germany
    Infect Immun 73:4704-13. 2005
    ..The Aspergillus antigens reported here may have value both in diagnostic tests for different forms of aspergillosis and as vaccine candidates for protection against invasive disease...
  58. pmc Detection of circulating Aspergillus fumigatus galactomannan: value and limits of the Platelia test for diagnosing invasive aspergillosis
    Claudine Pinel
    Service de Parasitologie Mycologie, Centre Hospitalier Universitaire, 38043 Grenoble, France
    J Clin Microbiol 41:2184-6. 2003
    ..0% (17 of 34 cases). The disappointing sensitivity associated with the presence of rare false-positive cases underlines the limits of this test...
  59. ncbi False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam
    Claudio Viscoli
    Infectious Disease Unit, National Institute for Cancer Research and University of Genoa, Genoa, Italy
    Clin Infect Dis 38:913-6. 2004
    ..Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results...
  60. pmc Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine
    Carla Bromuro
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, USA
    Infect Immun 70:5462-70. 2002
    ..Our observations may also help explain why subjects with elevated anti-Candida antibody titers, inclusive of anti-MP and anti-GG antibodies, remain nonetheless susceptible to invasive candidiasis...
  61. ncbi The role of apoptosis in the antigen-specific T cell hyporesponsiveness of paracoccidioidomycosis patients
    Camila R Cacere
    Laboratório de Alergia e Imunologia Clínica e Experimental, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin Immunol 105:215-22. 2002
    ..Our results suggest that apoptosis plays a role in the patients' antigen-specific hyporesponsiveness and that IL-10 may have an antiapoptotic role...
  62. pmc Dustborne Alternaria alternata antigens in US homes: results from the National Survey of Lead and Allergens in Housing
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 116:623-9. 2005
    ..Alternaria alternata is one of the most common fungi associated with allergic disease. However, Alternaria exposure in indoor environments is not well characterized...
  63. ncbi Serodiagnosis of mycoses using recombinant antigens
    Natalia Elguezabal
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Spain
    Mycopathologia 160:97-109. 2005
    ..The application of molecular biology techniques to the study of fungal antigens has allowed the production of recombinant antigens that may help to solve these problems...
  64. pmc Cryptococcal antigen test revisited: significance for cryptococcal meningitis therapy monitoring in a tertiary chinese hospital
    Hongzhou Lu
    Department of Infectious Diseases, Fudan University Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, People s Republic of China
    J Clin Microbiol 43:2989-90. 2005
    ..However, cryptococcal antigen can remain at low titers for long periods of time after therapy, even when fungus smears and/or cultures become negative...
  65. ncbi Detection of IgG and IgM in sera from canines with blastomycosis using eight blastomyces dermatitidis yeast phase lysate antigens
    Christine M Sestero
    Department of Biological Sciences, Idaho State University, Box 8007, Pocatello, ID 83209, USA
    Mycopathologia 162:33-7. 2006
    ..310-0.744 for IgG, 0.025-0.069 for IgM). Inherent variations in yeast lysate antigens such as these may be utilized to develop improved immunoassay procedures for the specific detection of IgG or IgM in cases of blastomycosis...
  66. ncbi In vitro granuloma formation, NO production and cytokines profile from human mononuclear cells induced by fractionated antigens of Paracoccidioides brasiliensis
    S N Diniz
    , , Belo Horizonte, MG, Brazil
    Hum Immunol 62:799-808. 2001
    ..The findings suggest that P. brasiliensis antigenic components participate in the modulation or activation of PBMC response in PCM, and IL-10 and NO could be important in the regulation of in vitro granuloma formation...
  67. pmc Molecular cloning, characterization, and expression of the M antigen of Histoplasma capsulatum
    R M Zancopé-Oliveira
    Laboratorio de Micologia Medica, Hospital Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Infect Immun 67:1947-53. 1999
    ..The gene encoding the major immunodominant M antigen of H. capsulatum is a presumptive catalase, and the recombinant protein retains serodiagnostic activity...
  68. pmc Cloning and disruption of the antigenic catalase gene of Aspergillus fumigatus
    J A Calera
    Laboratoire des Aspergillus, Institut Pasteur, Paris, France
    Infect Immun 65:4718-24. 1997
    ..In addition, there was no difference in pathogenicity between the cat1 mutant and its parental cat1+ strain in a murine model of aspergillosis...
  69. ncbi Value of antigen detection using an enzyme immunoassay in the diagnosis and prediction of invasive aspergillosis in two adult and pediatric hematology units during a 4-year prospective study
    A Sulahian
    Laboratoire de Parasitologie Mycologie, Hopital Saint Louis, Paris, France
    Cancer 91:311-8. 2001
    ..Early diagnosis is important to achieve the best outcome for these patients; however, definite proof often is difficult to obtain due to counterindicated invasive procedures...
  70. ncbi The GPI-anchored Gas and Crh families are fungal antigens
    Javier Arroyo
    Departamento Microbiología II, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain
    Yeast 24:289-96. 2007
    ..These results suggest that GPI-anchored cross-linking enzymes are relevant immunologically reactive constituents of the cell wall that may play a role during human fungal infections...
  71. pmc Effects of fungal N- and O-linked mannosylation on the immunogenicity of model vaccines
    Michael Luong
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, MA 02118, USA
    Vaccine 25:4340-4. 2007
    ..These data suggest that vaccines incorporating mannosylation must take into account how the mannose groups are linked to the core antigen and may need to include an adjuvant to stimulate cytokine production...
  72. pmc Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells
    Jennifer S Lam
    Department of Medicine and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 2:e1009. 2007
    ..In order to gain insight into the mechanisms responsible for this observation, the present study examined the cellular uptake of the mannosylated and deglycosylated recombinant proteins...
  73. ncbi Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell-mediated immunity in allergic bronchopulmonary aspergillosis (ABPA)
    B Banerjee
    Department of Paediatrics, Allergy-Immunology Division, Medical College of Wisconsin, Milwaukee, WI 53295, USA
    Clin Exp Allergy 31:761-70. 2001
    ....
  74. ncbi A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Cryptococcus neoformans infection
    R Fleuridor
    Departments of. Microbiology and Immunology and Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 166:1087-96. 2001
    ..neoformans and their efficacy in this study suggests that peptide mimotopes selected by protective Abs deserve further consideration as vaccine candidates for encapsulated pathogens...
  75. ncbi Performance characteristics of a polyclonal enzyme immunoassay for the quantitation of Histoplasma antigen in human urine samples
    Joann L Cloud
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
    Am J Clin Pathol 128:18-22. 2007
    ..The current EIA for the detection and quantitation of H capsulatum antigen in urine specimens is a valid assay that agrees well with results from an established reference laboratory...
  76. ncbi Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans: galactomannan, mannan and (1-->3)-beta-D-glucan antigens
    A Kedzierska
    Department of Clinical Microbiology, Chair of Clinical Immunology and Transplantology, Polish American Institute of Paediatrics, Jagiellonian University Medical College, 265 Wielicka Street, 30 663, Cracow, Poland
    Eur J Clin Microbiol Infect Dis 26:755-66. 2007
    ..Based on current literature, factors increasing the probability of obtaining false-positive or false-negative results detected by each test were also analysed and tabulated...
  77. pmc Detection of circulating gp43 antigen in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid of patients with paracoccidioidomycosis
    Silvia Helena Marques da Silva
    Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Sao Paulo, Brazil
    J Clin Microbiol 41:3675-80. 2003
    ..This novel, highly specific inh-ELISA represents a significant addition to the existing tests for the diagnosis of PCM...
  78. pmc Immunoglobulin G responses to a panel of Candida albicans antigens as accurate and early markers for the presence of systemic candidiasis
    Cornelius J Clancy
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    J Clin Microbiol 46:1647-54. 2008
    ..Taken together, our findings suggest that IgG responses against a panel of candidal antigens might represent an accurate and early marker of systemic candidiasis, a hypothesis that should be tested in future trials...
  79. ncbi Enumeration of functionally active anti-Aspergillus T-cells in human peripheral blood
    Olaf Beck
    Pediatric Hematology and Oncology, Children s Hospital III, Johann Wolfgang Goethe University, Frankfurt, Germany
    J Immunol Methods 335:41-5. 2008
    ..The presented method might help to define hematopoietic transplant recipients who will benefit from adoptive transfer of anti-Aspergillus T cells...
  80. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009
    ..b>Fungal antigens are ubiquitous within the environment and are well known triggers of allergic disease...
  81. ncbi Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors
    Michael K Mansour
    Evans Memorial Department of Clinical Research and Departments of Medicine and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 168:2872-9. 2002
    ....
  82. ncbi Aspergillus detection in bronchoscopically acquired material. Significance and interpretation
    H J Seyfarth
    Medizinische Klinik I, Abteilung Pneumologie, , Germany
    Mycoses 44:356-60. 2001
    ..Cultivation of Aspergillus was more successful in BAL, and the Aspergillus antigen detection was more successful in BL...
  83. ncbi Urine antigen detection of blastomycosis in pediatric patients
    Kanokporn Mongkolrattanothai
    Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, IL 61637, USA
    Pediatr Infect Dis J 25:1076-8. 2006
    ..For the first time, we report the effect of therapy on Blastomyces antigen clearance. In our experience, the urine antigen detection for B. dermatitidis is useful for diagnosis and follow up during therapy...
  84. ncbi Transcription regulation of the Pbgp43 gene by nitrogen in the human pathogen Paracoccidioides brasiliensis
    Antonio A Rocha
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, UNIFESP, Rua Botucatu, 862, oitavo andar, 04023 062 Sao Paulo, SP, Brazil
    Fungal Genet Biol 46:85-93. 2009
    ..This is the first report on PbGP43 transcription modulation in response to nitrogen primary sources, which might help understand its regulation during infection...
  85. ncbi Serology of paracoccidioidomycosis
    Zoilo Pires de Camargo
    Department of Microbiology, Immunology and Parasitology, Cellular Biology Division, Federal University of Sao Paulo UNIFESP, Rua Botucatu 862 8 andar, Sao Paulo, SP 04023 062, Brazil
    Mycopathologia 165:289-302. 2008
    ..Furthermore, detection of antigen in cerebrospinal fluid and in bronchoalveolar lavage fluid increases the sensitivity for diagnosis of PCM in central nervous system and in pulmonary infections, respectively...
  86. ncbi Redundancy, phylogeny and differential expression of Histoplasma capsulatum catalases
    Clayton H Johnson
    Central Arkansas Veterans Healthcare System, GRECC and Medical Research, VAMC 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Microbiology 148:1129-42. 2002
    ..A phylogenetic analysis of presently available catalase sequences and intron residences was done. The results support a model for evolution of eukaryotic monofunctional catalase genes from prokaryotic genes...
  87. ncbi Comparative analysis of cell wall surface glycan expression in Candida albicans and Saccharomyces cerevisiae yeasts by flow cytometry
    M Martinez-Esparza
    Departamento de Bioquímica y Biología Molecular B e Inmunología, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    J Immunol Methods 314:90-102. 2006
    ..The cytometric method described here represents a useful tool to investigate to what extent C. albicans is able to regulate its glycan surface expression and therefore modify its virulence properties...
  88. ncbi Cloning, characterization, and epitope expression of the major diagnostic antigen of Paracoccidioides brasiliensis
    P S Cisalpino
    Department of Microbiology, Immunology and Parasitology, Universidade Federal de Sao Paulo, Sao Paulo, SP 04023 062, Brazil
    J Biol Chem 271:4553-60. 1996
    ..Internal and COOH-terminal gene fragments of the gp43 were expressed as recombinant fusion proteins, which reacted with antibodies elicited against the native antigen...
  89. pmc Exposure to Alternaria alternata in US homes is associated with asthma symptoms
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 118:892-8. 2006
    ..Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments...
  90. ncbi Colonization of mice by Candida albicans is promoted by chemically induced colitis and augments inflammatory responses through galectin-3
    Samir Jawhara
    Inserm U 799, Physiopathologie des Candidoses, Faculte de Medecine, Centre Hospitalier Regional Universitaire de Lille, Institut Fédératif de Recherche 114, Universite Lille 2, Lille, France
    J Infect Dis 197:972-80. 2008
    ..Little is known about the relationship between colonic inflammation and Candida albicans colonization. Galectin-3 (Gal-3) is an intestinal lectin that binds to specific C. albicans glycans and is involved in inflammation...
  91. ncbi Role of anti-beta-glucan antibody in host defense against fungi
    Ken Ichi Ishibashi
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    FEMS Immunol Med Microbiol 44:99-109. 2005
    ..It was suggested that the anti-beta-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi...
  92. ncbi [Early diagnosis of invasive fungal infections caused by Aspergillus and other emerging mycelial fungi]
    Amalia del Palacio
    Unidad de Micologia, Servicio de Microbiologia, Hospital Doce de Octubre, Madrid, Spain
    Rev Iberoam Micol 24:187-97. 2007
    ..Antigen based assays or measurement of (1-3)-beta-D-glucan in blood have been developed and validated in clinical laboratories. We review these diagnostic contemporary tools, their clinical application and impact...
  93. ncbi Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease
    Astrid Konrad
    Division of Gastroenterology, Inselspital, University of Bern, Freiburgstrasse, Switzerland
    Inflamm Bowel Dis 10:97-105. 2004
    ..A proportion of CD patients develop antibodies against the yeast Saccharomyces cerevisiae (ASCA), but little is known about the cellular immune reactivity against food antigens in antibody-positive and -negative patients...
  94. ncbi [Serological tests for diagnosing fungal infections]
    Cornelia Lass-Flörl
    Department für Hygiene, Mikrobiologie und Sozalmedizin, Medizinische Universitat Innsbruck, Innsbruck, Osterreich
    Wien Med Wochenschr 157:526-9. 2007
    ..These approaches include detection of specific host immune responses to fungal antigens, and detection of specific macromolecular antigens using immunologic reagents...
  95. pmc Use of sera from humans and dolphins with lacaziosis and sera from experimentally infected mice for Western Blot analyses of Lacazia loboi antigens
    Leonel Mendoza
    Biomedical Laboratory Diagnostics Program, Michigan State University, 322 North Kedzie Hall, East Lansing, MI 48824 1031, USA
    Clin Vaccine Immunol 15:164-7. 2008
    ..loboi extracts. This study is the first to examine the humoral response to L. loboi antigens by using multiple host sera...
  96. ncbi Occurrence of Antibodies to Paracoccidioides brasiliensis in dairy cattle from Mato Grosso do Sul, Brazil
    L H Silveira
    Departamento de Ciências Patológicas, Centro de Ciencias Biologicas, Universidade Estadual de Londrina, Campus Universitario, Londrina, PR, Brazil
    Mycopathologia 165:367-71. 2008
    ..brasiliensis develop humoral immune response for gp43, remaining with high titers of antibodies, and that this animal species could be an epidemiologic marker of paracoccidioidomycosis...
  97. ncbi Immune responsiveness of a novel peptidoglycan conjugate prepared from surface Candida immunogens: mannan and CR3-related protein
    Ema Paulovicova
    Center for Glycomics, Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
    FEMS Immunol Med Microbiol 53:421-8. 2008
    ..Altogether, it could be assumed that the novel peptide glycoconjugate is a prospective antigenic candidate for further Candida vaccine design...
  98. pmc Comparative evaluation of (1, 3)-beta-D-glucan, mannan and anti-mannan antibodies, and Candida species-specific snPCR in patients with candidemia
    Fasahat F Alam
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, P, O, Box 24923, Kuwait
    BMC Infect Dis 7:103. 2007
    ..In this retrospective study, attention has been focused to evaluate the usefulness of two or more disease markers in the diagnosis of candidemia...
  99. pmc Improvement of the specificity of an enzyme-linked immunosorbent assay for diagnosis of paracoccidioidomycosis
    C F Albuquerque
    Department of Microbiology, Immunology and Parasitology, Cellular Biology Discipline, Federal University of Sao Paulo, Brazil
    J Clin Microbiol 43:1944-6. 2005
    ..The maximum specificity found in this ELISA was 84%. All of these procedures proved inefficient for eliminating all cross-reacting antibodies and obtaining an ELISA specific for PCM diagnosis...
  100. pmc Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 14:638-40. 2007
    ..Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results...
  101. ncbi Diagnosis of paracoccidioidomycosis by a dot blot assay using a recombinant Paracoccidioides brasiliensis p27 protein
    M M Correa
    Grupo de Microbiología Molecular, Escuela de Bacteriología y Laboratorio Clínico, Universidad de Antioquia, Medellin, Colombia
    Mycoses 50:41-7. 2007
    ..These results confirm the value of the 27-kDa recombinant antigen in the serodiagnosis of paracoccidioidomycosis and that the dot blot format is an alternative to the immunoenzymatic assay procedure...

Research Grants56

  1. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..of immunoassays for diagnosis is a determination of which of the potentially hundreds or thousands of fungal antigens produced in vivo will show up in body fluids in concentrations sufficient for detection...
  2. Glucan Particles as a Vaccine Platform for Protective Immunity
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..Aim 2 is to investigate the efferent mechanisms by which fungal antigens complexed in GPs protect against Hc infection in mice...
  3. Immunoassay for diagnosis of invasive fungal disease
    Thomas R Kozel; Fiscal Year: 2013
    ..Criteria for success in this Phase I STTR would be production of mAbs reactive with two distinct fungal antigens, one a polysaccharide and the other a protein, that are shared by the major causes of IFD...
  4. Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis Patients
    Hirohito Kita; Fiscal Year: 2007
    ..in response to bacterial superantigens; and immune cell activation in the response of CRS patients to fungal antigens in sinus mucus...
  5. EXPERIMENTAL CANDIDA ALBICANS ENDOCARDITIS
    Richard Calderone; Fiscal Year: 1980
    ..We have also constructed an indirect ELISA inhibition assay for quantitating fungal antigens during the early course of the disease...
  6. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..Towards this goal, the parent grant is analyzing in vitro lymphocyte and eosinophil responses to fungal antigens in conjunction with in vivo analyses of eosinophilic inflammation and antifungal treatment...
  7. Studies on the Pathogenesis of Chronic Rhinosinusitis
    Jean Kim; Fiscal Year: 2007
    ..of stimuli likely to participate in CRS (cytokines, toll-like receptor ligands, human rhinovirus and fungal antigens) on costimulator expression and to probe the mechanism of the effect...
  8. Mycology Research Unit: In Vivo Induced Fungal Antigens
    M Hong Nguyen; Fiscal Year: 2008
    The Mycology Research Unit: In Vivo Induced Fungal Antigens Program Project consists of four interrelated research projects and a Clinical Resource Core organized around the identification of C. albicans and A...
  9. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
    ..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
  10. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
  11. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  12. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
  13. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  14. Aspergillosis: Engineering Antibody for Diagnosis
    Marta Feldmesser; Fiscal Year: 2006
    ..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
  15. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  16. MODULATION OF TH1/TH2 RESPONSES BY INNATE IMMUNITY
    GARY HUFFNAGLE; Fiscal Year: 2004
    ..One of the potential implications of these studies is that therapies inhibiting melanin biosynthesis or activity may also have an adjuvant effect and promote the development of protective Th1 immunity to C. neoformans. ..
  17. HUMAN ANTIBODIES TO CRYPTOCOCCUS NEOFORMANS
    Liise Anne Pirofski; Fiscal Year: 2009
    ..neoformans and provide proof of principle that vaccines can be developed that focus the immune response on cellular subsets that can induce protection: ..
  18. Chemokines in pathogenesis of Experimental Arthritis
    SEEMA SINGH AHUJA; Fiscal Year: 2010
    ..Thus information obtained from proposed studies which explore how CCR2 modulates arthritis will have significant impact on potential therapeutic strategies to treat this chronic deblitating disease. ..
  19. Heat Shock Proteins and Helicobacter Pylori Pathogenesis
    Evelyn Kurt Jones; Fiscal Year: 2006
    ..Specifically, we will use in vitro and in vivo approaches to investigate the role of heat shock proteins in H. pylori infection and pathogenesis and development of tumors. ..
  20. VARIABLE GENE DEFECTS AND PNEUMOCOCCAL SUSCEPTIBILITY
    Liise Anne Pirofski; Fiscal Year: 2010
    ..The proposed studies will advance our understanding of how pneumococcal vaccine works. ..
  21. 6th International Conf. on Cryptococcus & Cryptococcosis
    STUART LEVITZ; Fiscal Year: 2005
    ..neoformans and Cryptococcosis and to recommend new and future research initiatives and prioritize these. ..
  22. Model Vaccines Exploiting Fungal Mannosylation
    STUART LEVITZ; Fiscal Year: 2009
    ....
  23. CHEMOKINE RECEPTORS IN IMMUNITY TO C NEOFORMANS
    GARY HUFFNAGLE; Fiscal Year: 2003
    ..neoformans infection; (5) To determine the role of MCP-1 and CCR2 in the development of a Th2 response to C. neoformans. ..
  24. T CELLS AND IMMUNITY TO CRYPTOCOCCOSIS
    JUNEANN MURPHY; Fiscal Year: 2003
    ..The information obtained from these studies will be useful for designing effective immunoreplacement and immunomodulatory therapies. ..
  25. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..abstract_text> ..
  26. Role of Fungal Microflora in Mucosal Tolerance/Immunity
    GARY HUFFNAGLE; Fiscal Year: 2009
    ..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..
  27. Antifungal Drug Susceptibility of Cryptococcus neoformans
    Robert Larsen; Fiscal Year: 2009
    ....
  28. VARIABLE GENE USE AND PNEUMOCOCCAL IMMUNITY IN AIDS
    Liise Anne Pirofski; Fiscal Year: 2010
    ..pneumoniae that will translate into identification of new correlates of vaccine efficacy and the generation of hypotheses for future testing in human studies. ..
  29. EST ANALYSIS OF A BASIDIOMYCETE CRYPTOCOCCUS NEOFORMANS
    JUNEANN MURPHY; Fiscal Year: 2002
    ..neoformans. ESTs will be useful to identify ORFs, new drug targets, new virulence markers, cell surface adherence factors, and metabolic and signaling pathways. ..
  30. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  31. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
    ..The goal of these comprehensive, integrated studies of HIV sensory neuropathy in our novel SIV primate model is to advance the understanding of HIV-SN pathogenesis to foster new therapeutic approaches. ..
  32. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  33. IMMUNOMODULATION DURING PULMONARY CRYPTOCOCCOSIS
    JUNEANN MURPHY; Fiscal Year: 2001
    ....
  34. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  35. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  36. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  37. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..This project will create a new program involving investigators who have not previously worked together, while building on institutional strengths and programmatic initiatives. ..
  38. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
  39. 8th ASM Conference on Candida and Candidiasis
    Paul Fidel; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  40. Impact of efavirenz resistance mutations on HIV-1
    Christine Koval; Fiscal Year: 2006
    ..abstract_text> ..
  41. Photodynamic therapy of oral candidiasis
    CONSTANTINE HAIDARIS; Fiscal Year: 2005
    ..2b. To demonstrate proof of principle of PDT in the treatment of C. albicans infection in the oral cavity of rats in vivo. ..
  42. Prevention/diagnosis/fungal infections/transplantation
    Barbara Alexander; Fiscal Year: 2005
    ..This approach will shorten the time from development to clinical implementation in therapeutic trials and guidelines. ..
  43. Chemokine System in DC and Lymphocyte Function
    SEEMA AHUJA; Fiscal Year: 2005
    ....
  44. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006
    ..abstract_text> ..
  45. MACROPHAGE INTERACTIONS WITH C. NEOFORMANS
    STUART LEVITZ; Fiscal Year: 2005
    ..Completion of these aims will add significantly to our understanding of the immunopathogenesis of cryptococcosis and may suggest novel approaches to the prevention and treatment of this life-threatening mycosis. ..
  46. MUCOSAL CELL MEDIATED IMMUNITY IN VAGINAL CANDIDIASIS
    Paul Fidel; Fiscal Year: 2006
    ..The long term goal is to understand vaginal host defense mechanisms against C. albicans so that immunotherapeutic strategies can be developed to prevent or treat disease. ..
  47. ORAL IMMUNE DYSFUNCTION AND CANDIDIASIS IN HIV INFECTION
    Paul Fidel; Fiscal Year: 2007
    ..abstract_text> ..
  48. RECOMBINANT HUMAN INTERLEUKIN-4 RECEPTOR IN ASTHMA
    Larry Borish; Fiscal Year: 2004
    ..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
  49. Role of Oxylipins in Cryptococcal Pathogenesis
    GARY HUFFNAGLE; Fiscal Year: 2008
    ..production; (3) to determine the role of the fungal oxylipin CnPGEx in cryptococcal biology and pathogenesis; (4) to determine the role of host PGE2 and other prostaglandins in cryptococcal biology and host immunity ..
  50. Pheromone Signaling in Pneumocystis Carinii
    Charles Thomas; Fiscal Year: 2009
    ..Through these investigations we hope to gain insights into P. carinii biology which may provide new information for novel drug development to treat PCP. ..
  51. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  52. CANDIDA ALBICANS SURFACE ANTIGENS
    Jim Cutler; Fiscal Year: 2006
    ....
  53. STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENES
    James Stringer; Fiscal Year: 2009
    ..abstract_text> ..
  54. Viral Host Interactions in SIV Cardiac Dysfunction
    Joseph Mankowski; Fiscal Year: 2008
    ..These studies will set the stage for performing interventive studies in SIV-infected macaques using approaches to target specific MMPs to prevent cardiac dysfunction. [unreadable] [unreadable] [unreadable]..