t lymphocyte epitopes

Summary

Summary: Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.

Top Publications

  1. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
  2. ncbi Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
    Will Fischer
    Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Nat Med 13:100-6. 2007
  3. ncbi Analysis of a successful immune response against hepatitis C virus
    S Cooper
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    Immunity 10:439-49. 1999
  4. pmc Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1
    Yaoyu E Wang
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    J Virol 83:1845-55. 2009
  5. ncbi Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    Heiner Wedemeyer
    Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3447-58. 2002
  6. ncbi A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes
    Manoj Bhasin
    Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India
    J Biosci 32:31-42. 2007
  7. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
  8. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
  9. ncbi HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 174:7524-30. 2005
  10. pmc T-cell epitope prediction: rescaling can mask biological variation between MHC molecules
    Aidan MacNamara
    Department of Immunology, Imperial College School of Medicine, London, United Kingdom
    PLoS Comput Biol 5:e1000327. 2009

Detail Information

Publications286 found, 100 shown here

  1. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
    ..At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo...
  2. ncbi Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
    Will Fischer
    Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Nat Med 13:100-6. 2007
    ..Mosaics provide diversity coverage comparable to that afforded by thousands of separate peptides, but, because the fragments of natural proteins are compressed into a small number of native-like proteins, they are tractable for vaccines...
  3. ncbi Analysis of a successful immune response against hepatitis C virus
    S Cooper
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    Immunity 10:439-49. 1999
    ..Every specificity shown during acute hepatitis persisted in normal liver tissue more than 1 yr after resolution. These results suggest that CD8+CTL are better correlated with protection against HCV infection than antibodies...
  4. pmc Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1
    Yaoyu E Wang
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    J Virol 83:1845-55. 2009
    ....
  5. ncbi Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    Heiner Wedemeyer
    Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3447-58. 2002
    ..Thus, the defective functions of HCV-specific CD8+ T cells might contribute to viral persistence in chronically infected patients, and knowledge on their reversibility may facilitate the development of immunotherapeutic vaccines...
  6. ncbi A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes
    Manoj Bhasin
    Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India
    J Biosci 32:31-42. 2007
    ..The method is available on the web at www.imtech.res.in/raghava/nhlapred and its mirror site is available at http://bioinformatics.uams.edu/mirror/nhlapred/...
  7. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
    ..These results have implications for the study of human chronic infections, where similar T-cell deletion and functional dysregulation has been observed...
  8. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
    ..Together, these data indicate that viral escape from CD8+ T cell responses occurs during human HCV infection and that acute immune selection pressure is of sufficient magnitude to influence HCV evolution...
  9. ncbi HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 174:7524-30. 2005
    ..Taken together, these findings indicate that the developing immune system of children may exhibit greater plasticity in responding to a continually evolving chronic viral infection...
  10. pmc T-cell epitope prediction: rescaling can mask biological variation between MHC molecules
    Aidan MacNamara
    Department of Immunology, Imperial College School of Medicine, London, United Kingdom
    PLoS Comput Biol 5:e1000327. 2009
    ..We suggest that there is biologically significant variation among class 1 MHC molecules and find that retention of this variation leads to significantly more accurate epitope prediction...
  11. ncbi A study of genetic diversity in the gene encoding the circumsporozoite protein (CSP) of Plasmodium falciparum from different transmission areas--XVI. Asembo Bay Cohort Project
    Ananias A Escalante
    Department of Biology, Emory University, Atlanta, GA, USA
    Mol Biochem Parasitol 125:83-90. 2002
    ..We conclude that it is inappropriate to use linkage-recombination patterns on genes under positive selection for assessing the structure of parasite populations...
  12. pmc The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
    Fleur E Tynan
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    J Exp Med 202:1249-60. 2005
    ..It also illustrates a novel mechanism through which MHC polymorphism can further diversify the immune response to infecting pathogens...
  13. ncbi Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11
    Marc Schmitz
    Medical Faculty, Institute of Immunology, Technical University of Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Cancer Lett 245:331-6. 2007
    ..This novel CTL epitope may serve as an attractive candidate for a T cell-based immunotherapy of glioma...
  14. pmc Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    M M Addo
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School Fenway Community Health Center Lemuel Shattuck Hospital, Boston, Massachusetts 02129, USA
    J Virol 77:2081-92. 2003
    ....
  15. ncbi Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
    Photini Kiepiela
    HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, Durban 4015, South Africa
    Nature 432:769-75. 2004
    ..The dominant involvement of HLA-B in influencing HIV disease outcome is of specific relevance to the direction of HIV research and to vaccine design...
  16. ncbi Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution
    Christoph Neumann-Haefelin
    Department of Medicine II, University of Freiburg, Germany
    Hepatology 43:563-72. 2006
    ..These results support the central role of virus-specific CD8+ T cells and the genetically determined restriction of the virus-specific T cell repertoire in HCV infection...
  17. ncbi The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
    ..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...
  18. ncbi HIV-1 epitope-specific CD8+ T cell responses strongly associated with delayed disease progression cross-recognize epitope variants efficiently
    Emma L Turnbull
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
    J Immunol 176:6130-46. 2006
    ..A better understanding of the features of T cell responses associated with long-term control of viral replication should facilitate rational vaccine design...
  19. ncbi Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
    L K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 11:733-42. 1999
    ..These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime...
  20. ncbi Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules
    S H van der Burg
    Department of Immunohematology and Blood Bank, Leiden University Medical Center, The Netherlands
    J Immunol 162:152-60. 1999
    ..Taken together, these data indicate that peptide RT171-190 constitutes an attractive component of vaccines aiming at induction or enhancement of HIV-1-specific T cell immunity...
  21. pmc Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy
    J P Casazza
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9113, USA
    J Virol 75:6508-16. 2001
    ....
  22. ncbi Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites
    Marie Laure Chesne-Seck
    Unité d Immunologie Structurale, CNRS URA 2185, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Mol Biochem Parasitol 144:55-67. 2005
    ....
  23. pmc Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
    J Virol 79:5665-75. 2005
    ..The results highlight the importance of NS3 and cross-reactive T cells during acute secondary infection but suggest that the overall breadth and magnitude of the T-cell response is not significantly related to clinical disease grade...
  24. pmc A linear peptide containing minimal T- and B-cell epitopes of Plasmodium falciparum circumsporozoite protein elicits protection against transgenic sporozoite challenge
    J Mauricio Calvo-Calle
    Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Infect Immun 74:6929-39. 2006
    ..falciparum CS repeats. These findings support further evaluation of linear peptides as economical, safe, and readily produced malaria vaccines for the one-third of the world's population at risk of malaria infection...
  25. ncbi HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nature 420:434-9. 2002
    ..The lack of cross-protective immunity for closely related HIV-1 strains, despite persistent recognition of multiple CD8 epitopes, has important implications for public health and vaccine development...
  26. ncbi Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    Julian Schulze zur Wiesch
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 175:3603-13. 2005
    ..This comprehensive characterization of CD4(+) T cell epitopes in resolved HCV infection provides important information to facilitate studies of immunopathogenesis and HCV vaccine design and evaluation...
  27. ncbi Plasmodium berghei-infected primary hepatocytes process and present the circumsporozoite protein to specific CD8+ T cells in vitro
    Silayuv E Bongfen
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 178:7054-63. 2007
    ..Thus, it can be hypothesized that infected hepatocytes can contribute in vivo to the elicitation and expansion of a T cell response...
  28. ncbi HLA-A2 and -A24-restricted glypican-3-derived peptide vaccine induces specific CTLs: preclinical study using mice
    Yutaka Motomura
    Cancer Immunotherapy Project, Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa 277 8577, Japan
    Int J Oncol 32:985-90. 2008
    ..The results of this study suggested that IFA is one of the indispensable adjuvants for peptide-based immunotherapy, and that the immunological effect of peptide vaccines depends on the dose of peptide injected...
  29. pmc Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 80:6318-23. 2006
    ..We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus...
  30. ncbi Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection
    C Pope
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 166:3402-9. 2001
    ..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses...
  31. pmc Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy
    Ann M Leen
    Center for Cell and Gene Therapy, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    J Virol 82:546-54. 2008
    ....
  32. ncbi Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:3535-42. 2007
    ..These data suggest that memory T cell pools become progressively dysregulated over time and this may have a significant impact on immune responsiveness in the aged...
  33. ncbi A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule
    Fleur E Tynan
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nat Immunol 8:268-76. 2007
    ..Our findings represent a mechanism of antigen recognition whereby the plasticity of the T cell response is dictated mainly by adjustments in the MHC-bound peptide...
  34. ncbi Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 173:3925-34. 2004
    ..Taken together, we show that LMP2 and LMP7 can at least in part determine subdominance and shape the epitope hierarchy of CTL responses in vivo...
  35. pmc Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation
    Mark J Geels
    Department of Human Retrovirology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    J Virol 79:11247-58. 2005
    ....
  36. pmc Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity
    John T Loffredo
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 182:7763-75. 2009
    ....
  37. pmc Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    Stuart C Ray
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Exp Med 201:1753-9. 2005
    ..These data suggest that vaccines for genetically diverse viruses may be more effective if they represent consensus sequence, rather than a human isolate...
  38. pmc Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge
    Nancy A Wilson
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    J Virol 83:6508-21. 2009
    ....
  39. ncbi Vaccination in humans generates broad T cell cytokine responses
    Stephen C De Rosa
    Vaccine Research Center, National Institute of Allery and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 173:5372-80. 2004
    ..The presence and variability of these complex response profiles introduce the possibility that selective functional expression patterns may provide correlates for vaccine efficacy or disease progression...
  40. ncbi Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein
    E Koren
    Scios Inc, 6500 Paseo Padre Pkway, Fremont, CA 94555, USA
    Clin Immunol 124:26-32. 2007
    ..In conclusion, in silico prediction can be successfully used to identify Class II restricted T-cell epitopes within therapeutic proteins and predict immunogenicity thereof in humans...
  41. ncbi Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome
    Elizabeth D Kilpatrick
    Center for Infectious Disease and Vaccine Research, and Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 172:3297-304. 2004
    ..Intense CD8(+) T cell responses to SNV may be induced by the encounter of the unnatural human host to this zoonotic virus without coevolution. This may also be the immunopathologic basis of other life-threatening human virus infections...
  42. pmc Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection
    R Draenert
    Howard Hughes Medical Institute, Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts 02129, USA
    J Virol 78:630-41. 2004
    ..These data imply functional impairment of CD8 T-cell responses in late-stage infection that may not be reflected by gamma interferon-based screening techniques...
  43. pmc Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection
    Jianhong Cao
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:6867-78. 2003
    ..Many novel epitopes, particularly directed to Nef, Tat, and Env, and frequently with unique HLA restrictions, merit further consideration in vaccine design...
  44. ncbi Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells
    Casper Paludan
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 169:1593-603. 2002
    ..Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this role for CD4(+) Th1 cells extends to other tumors that escape MHC class I presentation...
  45. pmc DNA polymorphisms in the pepA and PPE18 genes among clinical strains of Mycobacterium tuberculosis: implications for vaccine efficacy
    Andrea M Hebert
    Epidemiology Department, School of Public Health, University of Michigan, 109 S Observatory Street, Ann Arbor, MI 48109 2029, USA
    Infect Immun 75:5798-805. 2007
    ..Thus, immunity induced by Mtb72F may not recognize a proportion of M. tuberculosis clinical strains...
  46. ncbi Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells
    Panayotis Verginis
    Divisions of Endocrinology and Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    J Immunol 174:7433-9. 2005
    ....
  47. ncbi Memory inflation: continuous accumulation of antiviral CD8+ T cells over time
    Urs Karrer
    Nuffield Department of Clinical Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
    J Immunol 170:2022-9. 2003
    ..This may be relevant for understanding the evolution of the large human CMV-specific CD8+ T cell populations seen in humans...
  48. ncbi Molecular typing of major histocompatibility complex class I alleles in the Indian rhesus macaque which restrict SIV CD8+ T cell epitopes
    Masahiko Kaizu
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Immunogenetics 59:693-703. 2007
    ..Furthermore, application of this technically simple and accurate typing method should facilitate selection, utilization, and breeding of rhesus macaques for AIDS virus pathogenesis and vaccine studies...
  49. ncbi CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons
    Angus J MacDonald
    Immune Regulation Research Group, Department of Biochemistry, Trinity College Dublin, Ireland
    J Infect Dis 185:720-7. 2002
    ..These findings demonstrate that T helper type 1 and regulatory T cells are induced against the same epitopes on the core protein during HCV infection...
  50. pmc NetMHCpan, a method for MHC class I binding prediction beyond humans
    Ilka Hoof
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Building 208, 2800, Lyngby, Denmark
    Immunogenetics 61:1-13. 2009
    ..The high performance of NetMHCpan-2.0 for non-human primates documents the method's ability to provide broad allelic coverage also beyond human MHC molecules. The method is available at http://www.cbs.dtu.dk/services/NetMHCpan...
  51. pmc Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection
    Cheryl L Day
    Nuffield Department of Medicine, The Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:434-8. 2007
    ..This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation...
  52. pmc Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
    Rika Draenert
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 203:529-39. 2006
    ..These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape...
  53. pmc Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 3:918-25. 2002
    ..In addition, we have established an in vivo approach for assessing the intricacies of antigen-specific T cell activation, migration, engagement, memory and other defining elements of adaptive immunity...
  54. ncbi Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys
    Michael H Newberg
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:319-28. 2006
    ....
  55. ncbi HBV core particles as a carrier for B cell/T cell epitopes
    P Pumpens
    Biomedical Research and Study Center, University of Latvia, Riga, Latvia
    Intervirology 44:98-114. 2001
    ..Combination of numerous experimental data on epitope display with the precise structural information enables a knowledge-based design of diagnostic, and vaccine and gene therapy tools on the basis of the HBc particles...
  56. pmc Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Virol 79:13239-49. 2005
    ..The stereotypic nature of acquired mutations provides support for biochemical constraints limiting HIV-1 evolution and for the impact of CD8 escape mutations on viral fitness...
  57. ncbi The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes
    A Immonen
    Department of Clinical Microbiology, University of Kuopio, Kuopio, Finland
    Clin Exp Allergy 37:939-47. 2007
    ..Despite the fact that most significant mammalian respiratory allergens are lipocalin proteins, information on the human T cell reactivity to these allergenic proteins is largely missing...
  58. ncbi The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: implications for the design of new vaccination strategies against AIDS
    Riccardo Gavioli
    Department of Biochemistry and Molecular Biology, Via L Borsari 46, University of Ferrara, 44100 Ferrara, Italy
    Vaccine 26:727-37. 2008
    ....
  59. ncbi Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma
    D Rimoldi
    Ludwig Institute for Cancer Research, Lausanne Branch, Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 165:7253-61. 2000
    ..These findings underscore the in vivo immunological relevance of CTL epitopes derived from nonprimary ORF products and support their use as candidate vaccines for inducing tumor specific cell-mediated immunity against cancer...
  60. ncbi TCR signal transduction in antigen-specific memory CD8 T cells
    Ellen N Kersh
    Department of Microbiology and Immunology, Emory Vaccine Center and Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:5455-63. 2003
    ..We propose that this regulatory mechanism might increase signal transduction in memory T cells, while limiting TCR cross-reactivity and autoimmunity...
  61. ncbi Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice
    Anne M Ercolini
    Department of Oncology, Sidney Kimmel Cancer Center at Johns Hopkins, Graduate Program in Immunology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Immunol 170:4273-80. 2003
    ..Discovery of this epitope allows for better characterization of the CD8(+) T cell responses in the neu-N mouse model in which neu-specific tolerance must be overcome to produce effective antitumor immunity...
  62. ncbi Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length
    Kate J Green
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Immunol 34:2510-9. 2004
    ..Furthermore, the potency of the response indicates that peptides of this length do not present a major structural barrier to CTL recognition...
  63. pmc Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy
    Georg M Lauer
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Virol 79:12979-88. 2005
    ..These data suggest that broad CD8(+) T-cell responses alone may be insufficient to contain HCV replication, and also that early therapy is effective independent of such responses...
  64. pmc Identification of key peptide-specific CD4+ T cell responses to human cytomegalovirus: implications for tracking antiviral populations
    G C Harcourt
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Clin Exp Immunol 146:203-10. 2006
    ..This simple approach will provide a robust and reliable as well as economic method for tracking peptide specific populations in health and disease...
  65. ncbi A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes
    G Geginat
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    J Immunol 166:1877-84. 2001
    ....
  66. ncbi Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cells
    Mikael J Pittet
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital, Lausanne, Switzerland
    J Immunol 171:1844-9. 2003
    ..Our results are relevant for ex vivo identification and isolation of T cells with potent antitumor activity for adoptive T cell therapy...
  67. pmc The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype
    A C M Boon
    Institute of Virology, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands
    J Virol 76:582-90. 2002
    ..Furthermore, the magnitude of the influenza virus-specific CTL response seems dependent on the HLA-A and -B phenotypes...
  68. pmc Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitope
    Nicholas J Maness
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 184:67-72. 2010
    ..Our data demonstrate both that the pathway from vaccination to immune response is not well understood and that products of alternate reading frames may be rich and untapped sources of T cell epitopes...
  69. ncbi Immune mediated and inherited defences against flaviviruses
    M A Brinton
    Department of Biology, Georgia State University, Atlanta 30302 4010, USA
    Clin Diagn Virol 10:129-39. 1998
    ..Resistance to flavivirus-induced disease can also be controlled via a non-immune mechanism involving the product of a naturally occurring murine gene, Flv...
  70. pmc Comprehensive screening for human immunodeficiency virus type 1 subtype-specific CD8 cytotoxic T lymphocytes and definition of degenerate epitopes restricted by HLA-A0207 and -C(W)0304 alleles
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    J Virol 76:4971-86. 2002
    ..These findings provide biological validation of HLA supertypes in HIV-1 CTL recognition and support earlier studies of cross-subtype CTL responses during HIV-1 infection...
  71. pmc Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    PLoS ONE 4:e5528. 2009
    ....
  72. pmc Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses
    Keith E Garrison
    Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA
    Clin Vaccine Immunol 16:1369-71. 2009
    ..T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects...
  73. pmc Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV
    D K Wong
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Virol 75:1229-35. 2001
    ..The high degree of concordance of HCV epitopes identified from liver and PBMC suggests that this strategy is a reasonable alternative to liver biopsy for characterizing the CTL response to HCV in chronically infected persons...
  74. ncbi The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytes
    F Buseyne
    Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Int Immunol 13:941-50. 2001
    ..This flexibility of the TCR is probably of great importance for control of viruses with high genetic variability, such as HIV...
  75. pmc Adaptation of HIV-1 to human leukocyte antigen class I
    Yuka Kawashima
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Nature 458:641-5. 2009
    ....
  76. ncbi Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression
    Hans Christian Probst
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Immunol 171:5415-22. 2003
    ..Thus, the observed absence of early CTL in persistent infections might not be the cause, but rather the consequence of viral persistence...
  77. ncbi Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition
    Lucas Malard Velloso
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Immunol 172:5504-11. 2004
    ....
  78. pmc Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
    Laurel Yong Hwa Lee
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 118:3478-90. 2008
    ..Thus, vaccine formulas inducing heterosubtypic T cell-mediated immunity may confer broad protection against avian and human influenza A viruses...
  79. pmc Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:9216-27. 2008
    ..Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response...
  80. ncbi Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus
    Kapil Vashisht
    Department of Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
    Vaccine 26:4747-53. 2008
    ..A survey of PRRSV isolates indicated that these two sites are relatively conserved with at most a two amino acid variation and thus should be considered for incorporation into a multi-valent vaccine against PRRS...
  81. pmc DNA sequences encoding CD4+ and CD8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene
    A E Fujimura
    Departamento de Microbiologia, Imunologia e Parasitologia, , , Brazil
    Infect Immun 69:5477-86. 2001
    ..Our observations suggest that plasmids expressing epitopes recognized by CD4+ and CD8+ T cells may have a better protective potential against infection with T. cruzi...
  82. ncbi HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1123-37. 2000
    ..falciparum validates our predictive strategy in a biologically relevant system and supports the potential for developing a broadly efficacious epitope-based vaccine against malaria focused on a limited number of peptide specificities...
  83. ncbi The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage
    Morten Nielsen
    Center for Biological Sequence Analysis, Technical University of Denmark, BioCentrum DTU, Building 208, 2800, Lyngby, Denmark
    Immunogenetics 57:33-41. 2005
    ..e., the specificity of TAP has evolved to fit the specificity of the proteasome. This evolutionary relationship allows for a more efficient antigen presentation...
  84. ncbi Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets
    Lili Wang
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Gene Ther 18:185-94. 2007
    ....
  85. ncbi Prediction of immunogenicity of therapeutic proteins: validity of computational tools
    Christine J Bryson
    Antitope Ltd, Babraham Research Campus, Babraham, Cambridge, UK
    BioDrugs 24:1-8. 2010
    ....
  86. ncbi Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Acquir Immune Defic Syndr 33:426-38. 2003
    ..Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine...
  87. ncbi Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo
    C C Norbury
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:4355-62. 2001
    ..We present additional findings that point to cross-priming as the likely mechanism for these protein-specific differences...
  88. ncbi Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
    ..However, their impact on viral replication during acute HIV-1 infection is not known...
  89. ncbi Cytolytic CD8+ T cells directed against a cryptic epitope derived from a retroviral alternative reading frame confer disease protection
    On Ho
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 176:2470-5. 2006
    ..These data indicate that ARF-derived epitopes are indeed relevant inducers of the immune system and demonstrate the importance of atypically generated peptides as functional Ag with a physiologic role in disease protection...
  90. ncbi Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 171:6173-7. 2003
    ..Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses...
  91. ncbi Embryonic stem cell-derived dendritic cells expressing glypican-3, a recently identified oncofetal antigen, induce protective immunity against highly metastatic mouse melanoma, B16-F10
    Yutaka Motomura
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Res 66:2414-22. 2006
    ..Human dendritic cells expressing glypican-3 would be a promising means for therapy of melanoma and hepatocellular carcinoma...
  92. ncbi Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections
    R J Hogan
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 166:1813-22. 2001
    ..The kinetics of persistence of Ag-specific CD8(+) T cells in the lung suggests that they play a key role in protective cellular immunity to respiratory virus infections...
  93. pmc Reconstruction of a pathway of antigen processing and class II MHC peptide capture
    Catherine X Moss
    Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 26:2137-47. 2007
    ....
  94. pmc Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection
    Yoshiyuki Yokomaku
    AIDS Research Center, National Institute of Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Virol 78:1324-32. 2004
    ..We emphasize the importance of testing HIV-1 variants in an endogenous expression system...
  95. ncbi Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
    Stephen J Turner
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Immunol 6:382-9. 2005
    ..Thus, the lack of prominent features in an antigenic complex of peptide and major histocompatibility complex class I is associated with a diminished spectrum of TCR usage...
  96. pmc Latent gene sequencing reveals familial relationships among Chinese Epstein-Barr virus strains and evidence for positive selection of A11 epitope changes
    R S Midgley
    CRUK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Virol 77:11517-30. 2003
    ..From these results, and the observation that mutant epitopes are consistently nonimmunogenic in vivo, we conclude that the immune selection hypothesis remains viable and worthy of further investigation...
  97. ncbi Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues
    D Valmori
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Lausanne, Switzerland
    J Immunol 160:1750-8. 1998
    ....
  98. ncbi CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
    AIDS 19:241-50. 2005
    ..To understand the mechanisms underlying the differential targeting of T-cell responses during HIV-1 disease progression...
  99. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
    ....
  100. pmc Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population
    Tae Furutsuki
    Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 78:8437-45. 2004
    ..Thus, HIV-1 with Nef138-10(2F) appears to be a cytotoxic-T-lymphocyte escape mutant and has been transmitted frequently by sexual contact among the highly A24-positive Japanese population...
  101. ncbi Computational immunology: The coming of age
    Nikolai Petrovsky
    National BioinformaticsCentre, University of Canberra and National Health Sciences Centre, Canberra Clinical School, Woden, Australian Capital Territory, Australia
    Immunol Cell Biol 80:248-54. 2002
    ....

Research Grants63

  1. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..The results will be broadly significant and impactful for those working in Mycology &Immunology. ..
  4. A Bi-Institutional Pilot Study of Vaccinations for Patients with Low Grade Glioma
    Edward G Shaw; Fiscal Year: 2010
    ..The overall objective of this pilot study is to collect immunological and safety data that will be used to decide whether a larger study of clinical efficacy is warranted. ..
  5. Synthetic nanoparticle vaccines for RSV
    THOMAS J POWELL; Fiscal Year: 2012
    ..The application of this innovative approach to RSV vaccine development will also impact vaccine development for other infectious diseases. ..
  6. Coadministration of capsid modified adenovirus for malaria vaccine development
    Alberto Moreno; Fiscal Year: 2013
    ..vivax vaccination regimen. We envision that our studies will provide valuable data to improve protective immune response induced by protein- based vaccines. ..
  7. Metabolic Engineering of Cancer for Immunotargeting
    Zhongwu Guo; Fiscal Year: 2012
    ....
  8. PATHOGENESIS AND IMMUNOREGULATION OF PLP-INDUCED R-EAE
    Stephen D Miller; Fiscal Year: 2010
    ....
  9. Combining AD epitope vaccine with innate immunity
    DAVID HASTINGS CRIBBS; Fiscal Year: 2013
    ..abstract_text> ..
  10. Multiple Approaches to Abeta Vaccination in Animal Models
    DAVID HASTINGS CRIBBS; Fiscal Year: 2013
    ..Finally, we will compare the best multi-epitope [unreadable]-syn DNA vaccine against our best multi-epitope A[unreadable] DNA vaccine in the mixed pathology DLB-AD Tg mice (40). ..
  11. Mechanisms of Immunogenicity of Factor VIII
    Shannon L Meeks; Fiscal Year: 2013
    ..In this project, we will develop a better understanding of the immune response to the factor VIII protein, which may lead to better treatment alternatives. ..
  12. CD8+ T Cell-Mediated Immunotherapy of Autochthonous SV40 T Antigen-Induced Tumors
    Todd D Schell; Fiscal Year: 2013
    ..The ability to apply this approach to multiple cancer types will be investigated and will provide insight for enhancement of this promising approach for the treatment of cancer. ..
  13. A Humanized mouse model of B-islet cell autoimmunity
    Grete Sonderstrup; Fiscal Year: 2010
    ....
  14. Malaria Vaccine Based on Self-Assembling Polypeptide Nanoparticles (SAPN)
    DAVID ERVIN LANAR; Fiscal Year: 2012
    ..This new vaccine platform holds promise for ultimately producing an inexpensive malaria vaccine for the developing world. ..
  15. Cloning of molecular targets of Cell Mediated Autoimmunity in Type 1 Diabetes
    Howard W Davidson; Fiscal Year: 2013
    ..abstract_text> ..
  16. T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Shu Man Fu; Fiscal Year: 2013
    ..This will provide a theoretical framework from which rational therapeutic approach can be devised. ..
  17. Epitope-driven deimmunization of Factor VIII
    ANNE SEARLS DE GROOT; Fiscal Year: 2010
    ..The proposed reengineered protein will be evaluated in a mice that have a hemophilia as well as in mice that have a human- like immune system. ..
  18. Bioinformatic analysis of the detailed immune system epitope repertoire
    Yoram Louzoun; Fiscal Year: 2009
    ..Another possible application is the detection of MHC haplotypes with overlapping epitopes for optimal match in allogeneic transplantations. ..
  19. Heteroclitic and modified T cell epitopes in coronavirus encephalomyelitis
    Jonathan A Trujillo; Fiscal Year: 2012
    ..This approach will be useful in design of vaccines that are directed at enhancing pathogen-specific CD8 T cell responses. ..
  20. Identifying the role of 4-1BB in generation and persistence of VACV-CD8 memory
    Yuan Zhao; Fiscal Year: 2010
    ..This study will benefit the development of better VACV vaccines for infectious diseases as well as cancer immunotherapy. ..
  21. Novel Heterologous Adenovirus Prime-Boost HIV-1 Vaccine
    Dan H Barouch; Fiscal Year: 2012
    ..To assess the mucosal immunogenicity and protective efficacy of the optimal vaccine regimen against multiple, low-dose, mucosal SIV challenges in rhesus monkeys with anti-Ad5 immunity. ..
  22. Role of CD4 T cell response in MHV-induced demyelination
    Stanley Perlman; Fiscal Year: 2013
    ..We will also determine whether pathogen-specific Tregs require expression of a second TCR [unreadable] chain, recognizing a self epitope, for suppressive function. ..
  23. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2010
    ....
  24. Alternative Pathways for CD4+ T Cell Epitope Generation from Influenza Antigens
    LAURENCE CRANE EISENLOHR; Fiscal Year: 2013
    ..In addition, they could point to new approaches to cancer immunotherapy, and provide important insight into the genesis and treatment of autoimmune diseases. ..
  25. Predictive algorithms for T cell epitope identification
    Soren Buus; Fiscal Year: 2009
    ..This program emphasizes epitope discovery for category A-C bioterrorism agents and emerging/re-emerging infectious diseases. ..
  26. Enzymatic modification of anti-DEC205 to manipulate its immunogenic properties
    Hidde L Ploegh; Fiscal Year: 2013
    ..If successful these strategies would open the door to creating desirable T cell responses without the use of infectious agents and generally improve options for immune manipulations to achieve therapeutic effect. ! ..
  27. Direct Epitope Identification and Validation
    William Hildebrand; Fiscal Year: 2009
    ..This program emphasizes epitope discovery for category A-C bioterrorism agents and emerging/re-emerging infectious diseases. ..
  28. Large Scale Antibody and T Cell Epitope Discovery Program
    PH D FRELINGER; Fiscal Year: 2009
    ..This program emphasizes epitope discovery for category A-C bioterrorism agents and emerging/re-emerging infectious diseases. ..
  29. ApoVax-SVN as a Novel Vaccine for Cancer Immunotherapy
    Haval Shirwan; Fiscal Year: 2007
    ..ApoImmune's novel immune system-based therapy, ApoVax104 vaccine, is a new, innovative approach to treating cancer and malignant neoplastic diseases. [unreadable] [unreadable] [unreadable]..
  30. ApoVax104-HPV as a Novel Vaccine for Cervical Cancer
    KATHRYN MACLEOD; Fiscal Year: 2009
    ..The overall goal of this project is to develop a therapeutic cervical cancer vaccine, ApoVax104-HPV, into a lead commercial product to test in a Phase I clinical trial. ..
  31. Complete Analysis of T cell Epitopes from Yellow Fever Virus
    Soren Buus; Fiscal Year: 2011
    ..abstract_text> ..
  32. Complete Analysis of T cell Epitopes from Yellow Fever Virus
    Soren Buus; Fiscal Year: 2012
    ..abstract_text> ..
  33. The Identification of HLA class I and class II T cell epitopes from Dengue Virus
    Keith A Reimann; Fiscal Year: 2009
    ..abstract_text> ..
  34. Immune epitope database for Type 1 diabetes, MS, lupus, and RA
    ALESSANDRO D SETTE; Fiscal Year: 2010
    ..In addition, the IEDB hosts a series of epitope analysis tools such as antibody and T cell epitope prediction algorithms, epitope homology discovery, HLA frequency analysis, and 3D epitope viewer/protein mapping tools. ..
  35. Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei
    Daniel Altmann; Fiscal Year: 2013
    ..abstract_text> ..
  36. Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei
    Daniel Altmann; Fiscal Year: 2011
    ..abstract_text> ..
  37. Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei
    Daniel Altmann; Fiscal Year: 2012
    ..abstract_text> ..
  38. Novel Linear Peptide Universal Malaria Vaccines
    Alberto Moreno; Fiscal Year: 2005
    ..falciparum, respectively. These approaches will provide strong data to evaluate the LPC approach as a ways forward for clinical trials, whether used singly or in combination with other malaria vaccine platforms. ..
  39. Identifying Epitopes Recognized by Influenza and Flavivirus.
    William Kwok; Fiscal Year: 2013
    ..abstract_text> ..
  40. Immune epitope database for Type 1 diabetes, multiple sclerosis, SLE and RA
    ALESSANDRO D SETTE; Fiscal Year: 2011
    ..In addition, the IEDB hosts a series of epitope analysis tools such as antibody and T cell epitope prediction algorithms, epitope homology discovery, HLA frequency analysis, and 3D epitope viewer/protein mapping tools. ..
  41. Analysis of T cell epitope repertoire
    Yoram Louzoun; Fiscal Year: 2007
    ..This part of the research will be done in colaboration with an experimental group studying the B and T cell repertoire in autoimmunity. [unreadable] [unreadable] [unreadable]..
  42. Immune Epitope Database: Infectious diseases
    Alessandro Sette; Fiscal Year: 2012
    ..In addition, the IEDB hosts a series of epitope analysis tools such as antibody and T cell epitope prediction algorithms, epitope homology discovery, HLA frequency analysis, and 3D epitope viewer/protein mapping tools. ..
  43. Immune epitope database and analyisis program: infectious diseases
    ALESSANDRO D SETTE; Fiscal Year: 2009
    ..In addition, the IEDB hosts a series of epitope analysis tools such as antibody and T cell epitope prediction algorithms, epitope homology discovery, HLA frequency analysis, and 3D epitope viewer/protein mapping tools. ..
  44. Immune Epitope Database: Infectious diseases
    Alessandro Sette; Fiscal Year: 2013
    ..In addition, the IEDB hosts a series of epitope analysis tools such as antibody and T cell epitope prediction algorithms, epitope homology discovery, HLA frequency analysis, and 3D epitope viewer/protein mapping tools. ..
  45. Development of a Malaria DNA Vaccine with Enchanced Immunogenicity
    Richard Markham; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This project is designed to develop a vaccine for malaria. Should this approach be successful, this vaccine could save the more than 1 million deaths that occur annually as a result of this infection. ..
  46. HELPER T CELL EPITOPE IMMUNODOMINANCE
    Samuel Landry; Fiscal Year: 2000
    ..This work also may contribute to understanding the initiation and propagation of autoimmune disorders since locally unstable antigen segments are preferred targets of immune attack. ..
  47. MALARIA VACCINE--ATTENUATED INFLUENZA & VACCINIA VECTORS
    Ruth Nussenzweig; Fiscal Year: 2001
    ..These attenuated vectors will be evaluated with regard to their safety and immunogenicity to induce antibodies and CD4+ and CD8+ T cell responses against malaria epitopes/antigens. ..
  48. AFP-BASED PRIME-BOOST IMMUNOTHERAPY OF HCC
    LISA BUTTERFIELD; Fiscal Year: 2006
    ..These proposed studies will permit us to determine the immunological impact of a plasmid prime-adenoviral boost directed towards a self tumor antigen and to define mechanisms of antigen presentation. ..
  49. CHARACTERIZATION OF PEPTIDE BINDING PROPERTIES OF HLA
    PAMELA BJORKMAN; Fiscal Year: 1992
    ....
  50. IMMUNOTHERAPY OF MYASTHENIA GRAVIS
    J Blalock; Fiscal Year: 2001
    ..Is there restricted usage of TCR by AChR 100-116 specific T-cells recognized by CTCR8? 6. Can EAMG-associated T-cells of other specificities be identified with complementary peptides to different AChR T-cell epitopes? ..
  51. A PILOT PHASE IB TRIAL OF A PSA PEPTIDE VACCINE
    David Peace; Fiscal Year: 2001
    ....
  52. T CELL EPITOPES OF THE MALARIA CS PROTEINS
    Elizabeth Nardin; Fiscal Year: 1991
    ..The studies will also establish the optimal in vitro assay(s) for measuring protective immunity and provide a means of monitoring the development of functional antisporozoite immune responses in naturally infected or vaccinated hosts...
  53. Antibodies Against Amyloid Beta-Protein Intermediates
    ROBERT LAWTON; Fiscal Year: 2003
    ..Generation and initial characterization of these antibodies in this phase will be the foundation for further in vitro and in vivo characterization in Phase II, as well as the scale-up of the antibody production. ..
  54. Investigating IL-6 Experimental Myasthenia Gravis
    Premkumar Christadoss; Fiscal Year: 2002
    ..To avoid non-specific immunosuppression by IL-6 antagonists, high-dose AChR T cell epitope tolerance could be given as maintenance therapy after the first course of combination immunotherapy. ..
  55. CARBOHYDRATE VACCINES FOR H INFLUENZAE B & S PNEUMONIAE
    Porter Anderson; Fiscal Year: 1993
    ..governing immunogenicity of Hib oligosaccharides coupled to the protein CRM-197, 2) To analyze the role of T lymphocyte epitopes of the CRM-197 component upon its carrier activity, by testing the reactivity with a panel of CRM-197-..
  56. ADJUVANTING RESPONSE TO PROTEIN/POLYSACCHARIDE VACCINES
    CLIFFORD SNAPPER; Fiscal Year: 2000
    ..These combined approaches will lay the groundwork for designing novel polysaccharide-based vaccines that stimulate high titer and persistent antibody in normal, neonatal and immune compromised hosts via systemic or mucosal routes. ..
  57. Large Scale Antibody and T Cell Epitope Discovery Program
    PH D PINILLA; Fiscal Year: 2009
    ..This program emphasizes epitope discovery for category A-C bioterrorism agents and emerging/re-emerging infectious diseases. ..