dermatophagoides antigens

Summary

Summary: Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.

Top Publications

  1. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
  2. ncbi The crystal structure of a major dust mite allergen Der p 2, and its biological implications
    U Derewenda
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Mol Biol 318:189-97. 2002
  3. ncbi Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan
    Chen Kuang Niu
    Division of Pediatric Pulmonology, Kaohsiung Chang Gung Children s Hospital, Department of Pediatrics, Medical College, Kaohsiung Medical University Hospital, Taiwan, ROC
    Respir Med 100:1374-83. 2006
  4. ncbi Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures
    Nhan Pham-Thi
    Department of Paediatric Pneumology and Allergy, Hopital Necker Enfants Malades, Paris, France
    Pediatr Allergy Immunol 18:47-57. 2007
  5. ncbi Low-dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics
    Brian Boehlecke
    J Allergy Clin Immunol 112:1241-3. 2003
  6. ncbi IgE- and FcepsilonRI-mediated enhancement of surface CD69 expression in basophils: role of low-level stimulation
    Maho Suzukawa
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 143:56-9. 2007
  7. ncbi IgE and IgG anti-house dust mite specificities in allergic disease
    Belinda J Hales
    Division of Molecular Biotechnology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia
    J Allergy Clin Immunol 118:361-7. 2006
  8. ncbi Frequency of allergic diseases following measles
    E Kucukosmanoglu
    Department of Pediatrics, Medical Faculty, Gaziantep University Istanbul, Turkey
    Allergol Immunopathol (Madr) 34:146-9. 2006
  9. ncbi [Asthma in the elderly--estimation of natural disease course]
    Andrzej Bozek
    Katedra i Klinika Chorób Wewnetrznych i Dermatologii Sl AM w Zabrzu
    Pol Arch Med Wewn 114:1079-83. 2005
  10. ncbi Intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy
    P Strong
    Medical Research Council Immunochemistry Unit, University of Oxford, Oxford UK
    Clin Exp Allergy 32:1794-800. 2002

Research Grants

  1. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
  2. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
  3. Environmental Exposures, NOS Genes, and Exhaled Nitric Oxide in Pediatric Asthma
    Adam Spanier; Fiscal Year: 2007
  4. Structural biology of cedar pollen allergy
    Terumi Midoro Horiuti; Fiscal Year: 2007
  5. Early Environmental Hygiene and Pediatric Atopy
    Christine C Johnson; Fiscal Year: 2006
  6. MULTI-LEVEL ANALYSIS OF URBAN CHILDHOOD ASTHMA RISK
    Rosalind Wright; Fiscal Year: 2004
  7. Maturation of Non-Specific Airways Reactivity
    Michael Grunstein; Fiscal Year: 2007
  8. Predictors of Spatial Patterns in Urban Air Pollution
    Jonathan Levy; Fiscal Year: 2006
  9. COCKROACH ALLERGEN EXPOSURE IN CHILDHOOD ASTHMA
    Sampson Sarpong; Fiscal Year: 2002
  10. Impact of Violence on Obesity & Reproductive Axes in Youth
    Rosalind J Wright; Fiscal Year: 2010

Detail Information

Publications219 found, 100 shown here

  1. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  2. ncbi The crystal structure of a major dust mite allergen Der p 2, and its biological implications
    U Derewenda
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Mol Biol 318:189-97. 2002
    ..The crystal structure suggests that binding of non-polar molecules may be essential to the physiological function of the Der p 2 protein...
  3. ncbi Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan
    Chen Kuang Niu
    Division of Pediatric Pulmonology, Kaohsiung Chang Gung Children s Hospital, Department of Pediatrics, Medical College, Kaohsiung Medical University Hospital, Taiwan, ROC
    Respir Med 100:1374-83. 2006
    ..p. and D.f. Tolerance with high-dose SLIT was good with few minor adverse events reported. Our results indicated that a 24-week SLIT is of clinical benefit to mite-sensitive asthmatic children in Taiwan...
  4. ncbi Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures
    Nhan Pham-Thi
    Department of Paediatric Pneumology and Allergy, Hopital Necker Enfants Malades, Paris, France
    Pediatr Allergy Immunol 18:47-57. 2007
    ..Under such conditions, only a complete, but ethically unfeasible, discontinuation of inhaled corticosteroid would have demonstrated a possible benefit of SLIT...
  5. ncbi Low-dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics
    Brian Boehlecke
    J Allergy Clin Immunol 112:1241-3. 2003
  6. ncbi IgE- and FcepsilonRI-mediated enhancement of surface CD69 expression in basophils: role of low-level stimulation
    Maho Suzukawa
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 143:56-9. 2007
    ..Upregulated CD69 expression on locally accumulated basophils in bronchial asthma may be attributed at least in part to a combination of local cytokines, especially IL-3, plus exposure to low levels of IgE-crosslinking allergens...
  7. ncbi IgE and IgG anti-house dust mite specificities in allergic disease
    Belinda J Hales
    Division of Molecular Biotechnology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia
    J Allergy Clin Immunol 118:361-7. 2006
    ..There are few studies that quantitatively compare IgE and IgG antibody binding to the major and minor house dust mite allergens...
  8. ncbi Frequency of allergic diseases following measles
    E Kucukosmanoglu
    Department of Pediatrics, Medical Faculty, Gaziantep University Istanbul, Turkey
    Allergol Immunopathol (Madr) 34:146-9. 2006
    ..The aim of this study was to investigate the frequency of allergic diseases following measles in childhood...
  9. ncbi [Asthma in the elderly--estimation of natural disease course]
    Andrzej Bozek
    Katedra i Klinika Chorób Wewnetrznych i Dermatologii Sl AM w Zabrzu
    Pol Arch Med Wewn 114:1079-83. 2005
    ..The study group consisted of 181 patients suffering from asthma, at mean age 69 +/- 2.1 yrs. Apart from retrospective analysis, spirometry, skin tests and serum IgE concentration were performed...
  10. ncbi Intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy
    P Strong
    Medical Research Council Immunochemistry Unit, University of Oxford, Oxford UK
    Clin Exp Allergy 32:1794-800. 2002
    ..To date there have been no studies on the effectivness of directly applying chitin microparticles to the respiratory tract as a treatment for allergic symptoms...
  11. ncbi Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized, placebo-controlled study
    Ko Huang Lue
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    Pediatr Allergy Immunol 17:408-15. 2006
    ..The clinical usefulness of this form of immunotherapy and the mechanism underlying its immunologic effects deserve further studies...
  12. ncbi Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma
    C E Lopuhaä
    Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Allergy 32:1720-7. 2002
    ..The level of allergen-specific IgE antibodies does not seem to be decisive for asthmatic symptoms. Moreover, levels of exposure to mite allergens do not seem to differ significantly between asthmatic and non-asthmatics individuals...
  13. ncbi An extensive study of human IgE cross-reactivity of Blo t 5 and Der p 5
    I Chun Kuo
    Department of Paediatrics, Faculty of Medicine, National University of Singapore
    J Allergy Clin Immunol 111:603-9. 2003
    ..The human IgE cross-reactivity between clinical important group 5 allergens, Blo t 5 and Der p 5, remains controversial...
  14. ncbi Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UK
    A Simpson
    North West Lung Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK
    Allergy 58:53-6. 2003
    ..pteronyssinus and to assess allergenic activity and cross-reactivity of recombinant (r) Group 5 allergens amongst these patients, who live in the UK and who are not exposed to B. tropicalis in their homes...
  15. ncbi Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7
    Paul M Carter
    Henry Ford Health System, Division of Allergy, Detroit, Michigan, USA
    Ann Allergy Asthma Immunol 90:41-4. 2003
    ..Several studies have suggested that exposure to house-dust mite (HDM) allergen in infancy increases the risk of developing asthma...
  16. ncbi Early-life domestic aeroallergen exposure and IgE sensitization at age 4 years
    Matias Torrent
    Menorca Health Area, Ib Salut, Menorca, Spain
    J Allergy Clin Immunol 118:742-8. 2006
    ....
  17. ncbi Lack of correlation between bronchial late allergic reaction to Dermatophagoides pteronyssinus and in vitro immunoglobulin E reactivity to histamine-releasing factor derived from mononuclear cells
    Ilona Kleine Budde
    Department of Immunopathology, Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, The Netherlands
    Ann Allergy Asthma Immunol 89:606-12. 2002
    ..Sera capable of passively sensitizing basophils to release histamine to HRF were designated IgE+ sera. IgE+ and HRF have been suggested to play a role in late allergic reaction (LAR)...
  18. ncbi Skin test reactivity to aeroallergens in Jamaicans: relationship to asthma
    J Knight-Madden
    Sickle Cell Unit, Tropical Medicine Research Institute, The University of the West Indies, Kingston 7, Jamaica, West Indies
    West Indian Med J 55:142-7. 2006
    ..Asthma causes significant morbidity and mortality in the developing world. It is thus important to identify modifiable risk factors...
  19. ncbi Association between mite allergen (Der p 1, Der f 1, Blo t 5) levels and microscopic identification of mites or skin prick test results in asthmatic subjects
    Manoel Medeiros
    Servico de Imunologia, Hospital Universitario Professor Edgar Santos, Federal University of Bahia, Salvador, Brazil
    Int Arch Allergy Immunol 129:237-41. 2002
    ..The present study analyzed the association between levels of HDM allergen and results of mite identification or skin prick test (SPT) in two different areas of Bahia, Brazil...
  20. ncbi Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Int Arch Allergy Immunol 131:119-26. 2003
    ..The main objective of this study was to determine prevalence and correlates of sensitivity to these mites in families with asthma and characteristics of persons sensitized to both...
  21. ncbi Specific allergens enhance elastase release in stimulated neutrophils from asthmatic patients
    Javier Monteseirín
    Departamento de Medicina, Servicio Regional de Immunología y Alergia, Hospital Universitario Virgen Macarena, Sevilla, Espana
    Int Arch Allergy Immunol 131:174-81. 2003
    ..In addition, we attempted to evaluate the relationship between neutrophil degranulation and lung function of the patients, measured as FEV(1)...
  22. ncbi Allergen sensitization to aeroallergens including Blomia tropicalis among adult and childhood asthmatics in Thailand
    Tassalapa Daengsuwan
    Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 21:199-204. 2003
    ..3% and 5.6%, respectively. Sensitization to other pollens and spores were less than 5%. This study confirms the importance of Dermatophagoides among Thai asthmatics...
  23. ncbi Importance of including Blomia tropicalis in the routine diagnosis of Venezuelan patients with persistent allergic symptoms
    F A Puccio
    Institute of Biomedicine, Central University of Venezuela, Caracas, Venezuela
    Allergy 59:753-7. 2004
    ..The prevalence of skin test and specific serum immunoglobulin (Ig)E reactivity to B. tropicalis in Venezuela has not been previously evaluated...
  24. ncbi A differing pattern of association between dietary fish and allergen-specific subgroups of atopy
    K Andreasyan
    National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia
    Allergy 60:671-7. 2005
    ..We examined the role of fish intake in the development of atopic disease with particular reference to the possibility of differential effects on allergen-specific subgroups of sensitization...
  25. ncbi Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens
    G Pittner
    Division of Immunopathology, Department of Pathophysiology, Vienna General Hospital, Medical University of Vienna, Austria
    Clin Exp Allergy 34:597-603. 2004
    ..Immunotherapy with mite allergen extracts is frequently performed if allergen avoidance is not possible or successful. However, highly controversial results have been reported for mite-specific immunotherapy...
  26. ncbi Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels
    Kátia R C Tobias
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Int Arch Allergy Immunol 133:365-70. 2004
    ..It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area...
  27. ncbi Protein sequence analysis of a novel 103-kDa Dermatophagoides pteronyssinus mite allergen and prevalence of serum immunoglobulin E reactivity to rDer p 11 in allergic adult patients
    C S Lee
    Department of Internal Medicine, Mackay Memorial Hospital, Mackay Junior College of Nursing, and Taipei Medical University, Taipei, Taiwan
    Clin Exp Allergy 34:354-62. 2004
    ..We have also cloned a novel high mw Dermatophagoides pteronyssinus (Dp) mite allergen, Der p 11...
  28. ncbi Mouse strain differences in eosinophilic airway inflammation caused by intratracheal instillation of mite allergen and diesel exhaust particles
    Takamichi Ichinose
    Department of Health Sciences, Oita University of Nursing and Health Sciences, 2944 9 Notsuharu, Oita 870 1201, Japan
    J Appl Toxicol 24:69-76. 2004
    ..The enhancing effects of DEP may be mediated by a cytokine increase in the local expression. Antigen-specific IgG1 may be an important immunoglobulin in the pathogenesis of allergic asthma enhanced by DEP...
  29. ncbi Allergen skin test reaction patterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life
    Duaine R Jackola
    Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 132:364-72. 2003
    ..Genetic studies of atopy rely upon evidence of abnormal IgE production, usually elevated total IgE or skin prick test (SPT) reactions. However, these measures may change with subject age...
  30. ncbi Identification of the major allergenic components in Blomia tropicalis and the relevance of the specific IgE in asthmatic patients
    Jaw Ji Tsai
    Section of Allergy and Clinical Immunology, Cathay General Hospital, Taipei, Taiwan, ROC
    Ann Allergy Asthma Immunol 91:485-9. 2003
    ..High prevalence of sensitization to B. tropicalis has been noted in asthmatic patients in Taiwan; however, the allergenic components and its impact on asthmatic patients remain to be clarified...
  31. ncbi CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responses
    Duaine R Jackola
    The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 139:217-24. 2006
    ..We sought to determine if a single nucleotide polymorphism in the CD14 promoter region is associated with atopy in atopic families, and to assess its influence on serum levels of CD14 and allergen-specific IgE and IgG1 responses...
  32. ncbi Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production
    L Cosmi
    Center of Research, Transfer, High Education DENOTHE, University of Florence, Firenze, Italy
    Clin Exp Allergy 36:261-72. 2006
    ....
  33. ncbi Comparison of the biological activity of the most common sublingual allergen solutions made by two European manufacturers
    Ralph Mosges
    Institute of Medical Statistics, Informatics, and Epidemiology, Medical Faculty, University of Cologne, Cologne, Germany
    Int Arch Allergy Immunol 139:325-9. 2006
    ..What is still lacking is a 'conversion rate' between the biological activities of different allergen solutions to determine the one with the higher concentration...
  34. ncbi Usefulness of specific immunotherapy in patients with severe perennial allergic rhinitis induced by house dust mite: a double-blind, randomized, placebo-controlled trial
    V A Varney
    RCMB Research Division, University Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 33:1076-82. 2003
    ..To evaluate the effectiveness of specific immunotherapy (SIT) in patients with severe house dust mite (HDM)-induced perennial allergic rhinitis using diary cards and objective endpoints...
  35. ncbi Correlation between skin tests to Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis in Cuban asthmatics
    R L Castro Almarales
    Allergens Department, National Center of Bioproducts BIOCEN, Havana, Cuba
    Allergol Immunopathol (Madr) 34:23-6. 2006
    ..The aim of this study was to determine the degree of polysensitization and correlation of the skin prick test (SPT) reaction size to these mites in asthmatic patients...
  36. ncbi Barnacle allergy: allergen characterization and cross-reactivity with mites
    S Marinho
    Immunoallergy Department, Dona Estefania Hospital, Lisbon, Portugal
    J Investig Allergol Clin Immunol 16:117-22. 2006
    ..The molecular allergens and possible cross-reactivity phenomena implicated (namely with mites) have not been established...
  37. ncbi Skin tests and conjunctival and bronchial challenges with extracts of Blomia tropicalis and Dermatophagoides pteronyssinus in patients with allergic asthma and/or rhinoconjunctivitis
    J C García Robaina
    Servicio Alergia, Hospital Universitario Nuestra Senora de la Candelaria, Tenerife, Canary Islands, Spain
    Int Arch Allergy Immunol 131:182-8. 2003
    ..Several studies have demonstrated a variable degree of allergenic cross-reactivity in vitro. However, only a few have addressed their allergenic cross-reactivity using challenge tests...
  38. ncbi House dust mite allergen (Derp1 and Blot5) levels in asthmatics' home in Hongkong
    Bao Qing Sun
    Department of Medicine, the University of Hongkong, Hongkong
    Chin Med Sci J 19:185-8. 2004
    ..To measure Derp1 and Blot5 allergen levels in asthmatics' homes in Hongkong...
  39. ncbi Limited IgE cross-reactivity between Dermatophagoides pteronyssinus and Glycyphagus domesticus in patients naturally exposed to both mite species
    José Arias-Irigoyen
    Consulta Privada, Huelva, Spain
    J Allergy Clin Immunol 120:98-104. 2007
    ..Contradictory results have been found when analyzing the IgE cross-reactivity among pyroglyphid mites and storage mites, as well as the role of these as true sensitizing agents...
  40. ncbi The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyper-responsiveness and atopy
    F Kauffmann
    Epidemiology and Biostatistics, INSERM U472, Villejuif, France
    Clin Exp Allergy 32:379-86. 2002
    ..Farming environment and traditional lifestyle seem to protect from childhood allergy...
  41. ncbi Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering
    Kuan Wei Chen
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Mol Immunol 45:2486-98. 2008
    ..Thus the rDer p 2 derivatives exhibited less in vivo allergenic activity and allergenicity than the Der p 2 allergen but preserved immunogenicity and may hence represent candidates for specific immunotherapy of house-dust mite allergy...
  42. ncbi Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort
    Euan R Tovey
    Woolcock Institute of Medical Research, Sydney, Australia
    J Allergy Clin Immunol 122:114-8, 118.e1-5. 2008
    ..There is uncertainty about the nature of the relationship between mite allergen exposure during infancy and the expression of allergic diseases in childhood...
  43. ncbi Characterization of Der p 21, a new important allergen derived from the gut of house dust mites
    M Weghofer
    Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Allergy 63:758-67. 2008
    ..The house dust mite (HDM) Dermatophagoides pteronyssinus is a major allergen source eliciting allergic asthma. The aim of the study was to identify new important HDM allergens associated with allergic asthma...
  44. ncbi The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma
    Sarah A Lewis
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:961-6. 2002
    ..07), with adjustment for race and poverty. We conclude that cockroach and cat allergens may contribute to asthma morbidity in sensitized women...
  45. ncbi Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization
    D B Tumas
    Department of Pathology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080-4918, USA
    J Allergy Clin Immunol 107:1025-33. 2001
    ..The results parallel the results reported with anti-IgE efficacy in allergic asthmatic human subjects...
  46. ncbi Anaphylaxis after hamster bites--identification of a novel allergen
    D L Lim
    Department of Paediatrics, National University of Singapore, Singapore
    Clin Exp Allergy 34:1122-3. 2004
    ..Hamsters are popular household pets and anaphylaxis after their bites have described. However, the putative allergen has not been identified...
  47. ncbi Seasonal variability of non-specific bronchial responsiveness in asthmatic patients with allergy to house dust mites
    G Riccioni
    Respiratory Physiopathology Center, G. D'Annunzio University, Chieti, Italy
    Allergy Asthma Proc 22:5-9. 2001
    ..However, mite- and grass-allergic patients had wider variations of NSBR, possibly reflecting changes in seasonal pollen concentration...
  48. ncbi Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions
    M Weghofer
    Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 35:1384-91. 2005
    ..These variations may influence allergenic activity and thus may have impact on diagnostic tests and specific immunotherapy...
  49. ncbi Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy
    Margit Weghofer
    Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 147:101-9. 2008
    ..The aim of this study was to produce, by recombinant DNA technology, a folded Der p 5 allergen for diagnostic, therapeutic and preventive purposes...
  50. pmc A genomewide search for quantitative-trait loci underlying asthma
    X Xu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 69:1271-7. 2001
    ..No significant or suggestive evidence of linkage for the other four traits was found...
  51. ncbi Does SIT to Der p protect from snail sensitization?
    P Meglio
    Department of Pediatrics, University of Tor Vergata, Via Ezio 19, 00192 Rome, Italy
    Allergy 57:868-9. 2002
  52. ncbi Therapeutic effect of Bacillus Calmette-Guerin with allergen on human allergic asthmatic patients
    Jaw Ji Tsai
    Department of Cathay Medical Research Institute, Cathay General Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 35:99-102. 2002
    ..pteronyssinus in conjunction with Bacillus Calmette-Guerin did not alter the non-specific airway hyperreactivity or D. pteronyssinus-specific immunoglobulin E in D. pteronyssinus-sensitive allergic asthmatic patients...
  53. ncbi Home intervention in the treatment of asthma among inner-city children
    M C Carter
    Department of Family Medicine, Emory University, Atlanta, GA, USA
    J Allergy Clin Immunol 108:732-7. 2001
    ..Furthermore, the results for children with mite allergy strongly suggest that decreasing relevant allergen exposure should be an objective of treatment in this population...
  54. ncbi Bronchial responsiveness in atopic adults increases with exposure to cat allergen
    Susan Chinn
    Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Respir Crit Care Med 176:20-6. 2007
    ..The association of asthma with sensitization and allergen exposure is known to be complex. There have been few studies of bronchial responsiveness in relation to both risk factors in adults...
  55. ncbi Der p 1 and Der p 2 induce less severe late asthmatic responses than native Dermatophagoides pteronyssinus extract after a similar early asthmatic response
    M J Van Der Veen
    Department of Pulmonology, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Exp Allergy 31:705-14. 2001
    ....
  56. ncbi Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma
    Cevdet Ozdemir
    Division of Pediatric Allergy and Immunology, School of Medicine, Marmara University, Istanbul, Turkey
    Pediatr Allergy Immunol 18:508-15. 2007
    ..Three years of SLIT as an adjunct to pharmacotherapy resulted in reduction of both the duration and dose of ICSs and successful discontinuation of ICSs along with improvement in lung functions in HDM-allergic children with asthma...
  57. ncbi Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests
    R S Mueller
    Animal Skin and Allergy Clinic, Mount Waverley, Victoria
    Aust Vet J 78:392-9. 2000
    ..To determine the most relevant aero-allergens involved in canine atopic dermatitis in southeastern Australia and provide information about these aero-allergens to the general practitioner...
  58. ncbi Sublingual desensitization in patients with wasp venom allergy: preliminary results
    G Patriarca
    Department of Allergology, Catholic University, Rome, Italy
    Int J Immunopathol Pharmacol 21:669-77. 2008
    ..Larger studies are needed to assess efficacy, safety and tolerability profile of wasp venom SLIT...
  59. ncbi Guanine content and Dermatophagoides pteronyssinus allergens in house dust samples
    J Le Mao
    Unite d Immuno Allergie, Institut Pasteur, Paris, France
    J Allergy Clin Immunol 83:926-33. 1989
    ..These results suggest that the guanine determination could assess mite allergens in house dust and may be a useful tool in large-scale investigations of house dust...
  60. ncbi Feather bedding and house dust mite sensitization and airway disease in childhood
    Anne Louise Ponsonby
    National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia
    J Clin Epidemiol 55:556-62. 2002
    ..However, prospective studies are required to fully exclude selection bias...
  61. ncbi Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis
    T J Nuttall
    Easter Bush Veterinary Centre, University of Edinburgh Hospital for Small Animals, Easter Bush, Midlothian EH25 9RG, UK
    Vet Immunol Immunopathol 84:143-50. 2002
    ....
  62. ncbi [Safety of hymenopteran venoms immunotherapy in a cluster schedule. A nursing perspective]
    M Catala
    Servicio de Alergologia, Centro de Consultas Conde Oliveto, Pamplona, Spain
    An Sist Sanit Navar 32:409-12. 2009
    ..The aim of this article is to evaluate the safety of a cluster schedule of subcutaneous hymenopteran venom immunotherapy, which reduces the time needed to reach the maintenance dose from 12 to 3 weeks...
  63. ncbi High efficacy and absence of severe systemic reactions after venom immunotherapy
    F Carballada
    Unidad de Alergia, Hospital Xeral de Calde, Lugo, Spain
    J Investig Allergol Clin Immunol 13:43-9. 2003
    ..Taking into account the tolerance observed during the maintenance treatment, we consider that its administration at PCCs is appropriate...
  64. ncbi Regulation of allergen products in Japan
    Reiko Teshima
    National Institute of Health Sciences, Tokyo, Japan
    Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess 96:224-9. 2009
    ..Egg, milk, wheat, buckwheat and peanut, and most recently shrimp and crab require mandatory labeling. Standardization of food allergens for allergenic ingredient measurement has been advanced...
  65. ncbi Effect of diesel exhaust particles on house dust mite-induced airway eosinophilic inflammation and remodeling in mice
    Go Takahashi
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Mitahora Higashi, Gifu 502 8585, Japan
    J Pharmacol Sci 112:192-202. 2010
    ....
  66. ncbi Comparison of three methods of protein extraction from Dermatophagoides pteronyssinus for two-dimensional electrophoresis
    Jin lu Sun
    Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chin Med Sci J 24:64-8. 2009
    ..To explore an effective method of Dermatophagoides pteronyssinus protein extraction suitable for two-dimensional electrophoresis (2-DE) analysis...
  67. ncbi Acid-induced polymerization of the group 5 mite allergen from Dermatophagoides pteronyssinus
    S H Liaw
    Department of Life Science, National Yang Ming University, 155 Li Nong Street, Sec 2, Taipei, Taiwan
    Biochem Biophys Res Commun 285:308-12. 2001
    ..Therefore, coiled-coil helices may be one of the common structural motifs of mite allergens that contribute to their allergenicity...
  68. doi [Nasal allergen provocation test, allergic skin tests and serum allergen-specific IgE level in asthmatic children]
    Andrzej Emeryk
    Klinika Chorób Płuc i Reumatologii, Akademii Medycznej w Lublinie
    Otolaryngol Pol 61:617-22. 2007
    ..The important element in the asthma diagnosis is a confirmation of trigger's asthma symptoms allergens...
  69. ncbi Comparison of mRAST and CAP with skin end point titration for Alternaria tenuis and dermatophagoides pteronyssinus
    D W Chambers
    Division of Otolaryngology, University of Missouri, Columbia, USA
    Otolaryngol Head Neck Surg 117:471-4. 1997
    ..These results were then compared with the results of patients who also underwent intradermal skin testing based on end point titration techniques...
  70. ncbi Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults
    Thomas M Kundig
    University of Zurich, Department of Dermatology, University Hospital Zurich, Switzerland
    J Allergy Clin Immunol 117:1470-6. 2006
    ..In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Qbeta (Qbeta-Der p 1)...
  71. pmc Inhaled house dust mite induces pulmonary T helper 2 cytokine production
    L G Gregory
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Clin Exp Allergy 39:1597-610. 2009
    ..Inhaled house dust mite (HDM) results in T-helper (TH) 2 type pathology in unsensitized mice, in conjunction with airway hyperreactivity and airway remodelling. However, the pulmonary cytokine and chemokine profile has not been reported...
  72. ncbi Modulation of the humoral response to Dermatophagoides pteronyssinus allergens in BALB/c mice by extract modification and adjuvant use
    Yago Pico de Coaña
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    Int Arch Allergy Immunol 157:331-8. 2012
    ..The objectives of this study were to investigate the humoral response generated in mice to modified Dermatophagoides pteronyssinus extracts in the presence or absence of two different adjuvants...
  73. ncbi Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity
    Birthe R Johannessen
    Biostructural Research, Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    FEBS Lett 579:1208-12. 2005
    ..Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes...
  74. ncbi Effect of insect growth regulators on protein pattern of dermatophagoides farinae and its validity on inducing human alleregens
    Said A M Mazyad
    Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt
    J Egypt Soc Parasitol 36:1101-14. 2006
    ..Consequently, the insect growth regulators minimized the allergic efficacy of D. farinae in experimental exposed mice...
  75. ncbi [Exposure and allergy to dust mites in general and working environment in Croatia]
    Jelena Macan
    Institut za medicinska istrazivanja i medicinu rada, Zagreb
    Arh Hig Rada Toksikol 55:183-92. 2004
    ..putrescentiae. So far, results do not indicate that pyroglyphid mites are occupational allergens in paper-recycling, fish-processing and tobacco-processing...
  76. ncbi Lower airway inflammation before and after house dust mite nasal challenge: an age and allergen exposure-related phenomenon
    F Marcucci
    Department of Obstetric, Gynaecologic, Pediatric Sciences, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06122 Perugia, Italy
    Respir Med 101:1600-8. 2007
    ..Upper and lower airways allergic disease is currently considered unitarily. Allergic inflammation in one site can extend to other sites of the respiratory tract...
  77. ncbi Effectiveness and stability of heterologous proteins expressed in plants by Turnip mosaic virus vector at five different insertion sites
    Chin Chih Chen
    Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, ROC
    Virus Res 130:210-27. 2007
    ..var. chinensis and B. campestris L. var. ching-geeng than those in the plants of B. juncea L. and B. campestris L. var. pekinensis...
  78. ncbi Proteases as Th2 adjuvants
    Martin D Chapman
    INDOOR Biotechnologies, Inc, 1216 Harris Street, Charlottesville, VA 22903, USA
    Curr Allergy Asthma Rep 7:363-7. 2007
    ..Thus although mite proteases allergens may act as Th2 adjuvants, a paradoxical effect is that other allergens may elicit strong Th2 responses in the absence of enzyme activity...
  79. ncbi Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitis
    Jeong Hoon Oh
    Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Allergy Asthma Proc 29:152-60. 2008
    ..Locally produced allergen-specific IgA (but not IgE or IgG) may be involved in eosinophil activation in both early and late responses...
  80. ncbi [Effects of house dust mite allergen DNA vaccines on the allergic airway inflammation in murine models]
    Yu tian Bi
    Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Zhonghua Nei Ke Za Zhi 46:930-3. 2007
    ..To investigate the effects of allergen DNA vaccines on the airway allergic inflammation in C57BL/6 mouse models sensitized and challenged with house dust mite extracts...
  81. ncbi Evaluation of IgG subclass responses against Dermatophagoides farinae allergens in healthy and atopic dogs
    Chia Chun Hou
    Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, Hospital for Small Animals, Easter Bush Veterinary Centre, The University of Edinburgh, Edinburgh, UK
    Vet Dermatol 17:103-10. 2006
    ..The role of the 180 kDa antigen warrants further study...
  82. ncbi Baseline laryngeal effects among individuals with dust mite allergy
    John H Krouse
    Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, MI 48201, USA
    Otolaryngol Head Neck Surg 139:149-51. 2008
    ..To examine baseline effects of perennial allergy on laryngeal appearance, laryngeal function, and perceived vocal handicap among individuals without current allergy or voice symptoms...
  83. ncbi Retrospective study of tolerance to short initiation schedules in subcutaneous immunotherapy
    B Gandarias
    ALK ABELLO, Medical Department, SA Madrid, Spain
    J Investig Allergol Clin Immunol 15:242-8. 2005
    ..Pangramin Plus tolerance, therefore, can be classified as good, similar to conventional schedules, but with the benefits of shorter initiation schedules...
  84. ncbi [Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study]
    Wojciech Silny
    Department of Dermatology and Allergic Diseases Diagnostic Centre, Medical University of Poznan, Poland
    Pol Merkur Lekarski 21:558-65. 2006
    ..There is extensive literature on the use of SIT in the management of respiratory allergies and insect venom hypersensitivity, but a paucity of published data concerning its use as a therapeutic approach in atopic dermatitis (AD)...
  85. ncbi Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study
    T Werfel
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    Allergy 61:202-5. 2006
    ..Therefore, a multi-centre, randomized dose-response trial, double-blind with respect to the efficacy of a biologically standardized depot house dust mite preparation was performed...
  86. ncbi Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2
    Krisztina Szalai
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Mol Immunol 45:1308-17. 2008
    ..Therefore, these mimotopes are potential candidates for the directed induction of blocking antibodies and epitope-specific immunotherapy of mite allergy...
  87. ncbi Cat allergen induces proinflammatory responses by human monocyte-derived macrophages but not by dendritic cells
    A C Andersson Lundell
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    Allergy 60:1184-91. 2005
    ..Our aim was to study the proinflammatory response of human monocytes and in vitro-generated macrophages and DC after contact with cat allergens...
  88. ncbi Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites
    Clair Phillips
    Department of Microbiology and Immunology, Institute for Lung Health, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom
    J Leukoc Biol 73:165-71. 2003
    ..We speculate that this innate mechanism may contribute to the development of a cytokine milieu that could promote immunoglobulin E synthesis, eosinophil recruitment, and the development of type 2 T cells...
  89. ncbi Mite antigens enhance ICAM-1 and induce VCAM-1 expression on human umbilical vein endothelium
    F Mastrandrea
    Allergy Operative Unit, AUSL TA1, SS Annunziata Hospital, Taranto, Italy
    Allergol Immunopathol (Madr) 31:259-64. 2003
    ..Although preliminary, these results clearly support the hypothesis that at least some of the effects of sublingual immunotherapy may derive from inflammatory cell recruitment at the site of allergen release...
  90. ncbi Woven material for bed encasement prevents mite penetration
    Vanna Mahakittikun
    J Allergy Clin Immunol 112:1239-41. 2003
  91. ncbi A sensitive reverse ELISA for the measurement of specific IgE to Der p 2, a major Dermatophagoides pteronyssinus allergen
    D A Silva
    Department of Immunology, Microbiology, and Parasitology, , MG, Brazil
    Ann Allergy Asthma Immunol 86:545-50. 2001
    ..Detection of specific IgE to major allergens and relevant peptides, and identification of B cell epitopes in allergens will provide valuable information for the design of allergen analogs and peptides for immunotherapy...
  92. ncbi Humanized anti-IgE mAb Hu-901 prevents the activation of allergen-specific T cells
    R J Van Neerven
    Tanox Pharma BV, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 124:400-2. 2001
    ..The aim of the present study was to determine whether humanized anti-IgE mAb Hu-901 can prevent the activation of allergen-specific T cells by inhibiting IgE-mediated allergen presentation...
  93. ncbi Reactivities of mutants of a major house dust mite allergen Der f 2 to mouse anti-Der f 2 monoclonal antibodies analyzed by immunoblotting
    T Takai
    Bioscience Research and Development Laboratory, Asahi Breweries, Ltd, Kitasoma-gun, Ibaraki, Japan
    Biosci Biotechnol Biochem 65:694-7. 2001
    ..Epitopes for five mouse anti-Der f 2 monoclonal antibodies, 1B2, 7C10, 13A4, 15E11, and 18G8, to the recombinant Der f 2 variants were characterized by immunoblot analysis...
  94. ncbi A rapid and efficient strategy to generate antigen-specific human monoclonal antibody by in vitro immunization and the phage display method
    Shin ei Matsumoto
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Immunol Methods 332:2-9. 2008
    ..We thus established a rapid, efficient method to obtain antigen-specific human antibody genes and produce human monoclonal IgG antibody using the phage antibody library generated from in vitro immunized PBMCs...
  95. ncbi Diversity of allergen exposure: implications for the efficacy of environmental control
    Gesmar Rodrigues Silva Segundo
    Programa de Imunologia e Parasitologia Aplicadas, Universidade Federal de Uberlandia
    Braz J Otorhinolaryngol 75:311-6. 2009
    ..The relationship between allergen exposure, atopic sensitization and development of allergic diseases is widely described in the literature...
  96. ncbi Birth month and sensitization to house dust mites in asthmatic children
    Y Yoo
    Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea
    Allergy 60:1327-30. 2005
    ..In fact, subjects sensitized to house dust mites (HDMs) have a significantly higher proportion of births in the season when HDMs are most abundant...
  97. ncbi Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children
    J Paola Contreras
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 112:1072-7. 2003
    ..The early childhood allergen-induced immune responses associated with atopic disease and IgE production in early life are not well understood...
  98. ncbi A randomized controlled trial of mite allergen-impermeable bed covers in adult mite-sensitized asthmatics
    C Luczynska
    Department of Public Health Sciences, King s College London, UK
    Clin Exp Allergy 33:1648-53. 2003
    ..Many allergen-avoidance regimes include multiple measures of allergen reduction, but as mite exposure in the home is most likely to be greatest in bed dust, bedding is usually the first target for intervention...
  99. ncbi Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients
    K Kowal
    Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland
    J Investig Allergol Clin Immunol 18:284-92. 2008
    ..Activation of individual cells by LPS is facilitated by CD14. The single nucleotide polymorphisms -675 4G/5G in SERPINE1 and C-159T in CD14 are major determinants of PAI-1 and CD14 expression, respectively...
  100. ncbi Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy
    Jonathan Corren
    Allergy Research Foundation, Los Angeles, CA 90025, USA
    J Allergy Clin Immunol 121:506-11. 2008
    ..It is not known whether stopping or reducing the dose of omalizumab maintains adequate suppression of free IgE levels and IgE-mediated mast cell activation...
  101. ncbi Environmental exposures and exhaled nitric oxide in children with asthma
    Adam J Spanier
    Cincinnati Children s Environmental Health Center, Division of General and Community Pediatrics, and the Division of Allergy and Clinical Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Pediatr 149:220-6. 2006
    ..To evaluate the relation of environmental factors with exhaled nitric oxide (FENO) concentrations among asthmatic children...

Research Grants28

  1. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
    ..The identification of chemokines that promote allergic asthma is an important step in the future development of therapeutics to target specific molecules within the airways. [unreadable] [unreadable] [unreadable]..
  2. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..abstract_text> ..
  3. Environmental Exposures, NOS Genes, and Exhaled Nitric Oxide in Pediatric Asthma
    Adam Spanier; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Structural biology of cedar pollen allergy
    Terumi Midoro Horiuti; Fiscal Year: 2007
    ..Midoro by incorporating expertise from diverse fields. Completion of this project should greatly enhance Dr. Midoro's chances of an independent research carrier. [unreadable] [unreadable]..
  5. Early Environmental Hygiene and Pediatric Atopy
    Christine C Johnson; Fiscal Year: 2006
    ..Further, working with Dr. F. Martinez, we will use the established repository of biospecimens to develop molecular epidemiologic studies of genetic-environmental risk factors. ..
  6. MULTI-LEVEL ANALYSIS OF URBAN CHILDHOOD ASTHMA RISK
    Rosalind Wright; Fiscal Year: 2004
    ..An additional feature of the proposal is the opportunity to involve under represented minority students (predoctoral and summer interns) from two NIH-funded grants whose principal investigator is a co-investigator on this proposal. ..
  7. Maturation of Non-Specific Airways Reactivity
    Michael Grunstein; Fiscal Year: 2007
    ....
  8. Predictors of Spatial Patterns in Urban Air Pollution
    Jonathan Levy; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  9. COCKROACH ALLERGEN EXPOSURE IN CHILDHOOD ASTHMA
    Sampson Sarpong; Fiscal Year: 2002
    ..Insights gained from this work may lead to preventive measures which may reduce the prevalence and morbidity of childhood asthma. ..
  10. Impact of Violence on Obesity & Reproductive Axes in Youth
    Rosalind J Wright; Fiscal Year: 2010
    ..In addition, salivary cortisol rhythms will be examined in relation to history of violence exposure and as a mediator between violence exposure and the proposed outcomes in a subsample (n=1200). ..
  11. Mouse Allergen Exposure & Mouse Allergic Sensitization
    Elizabeth Matsui; Fiscal Year: 2007
    ..In addition, improvements in the prediction of allergic sensitization would allow interventions to be targeted in a more practical and efficient manner to those at highest risk. [unreadable] [unreadable] [unreadable] [unreadable]..
  12. Mouse Allergen and Inner-City Asthma
    Elizabeth C Matsui; Fiscal Year: 2010
    ....
  13. Cytokine Polymorphisms and Hodgkin Lymphoma Risk
    Wendy Cozen; Fiscal Year: 2006
    ..This study is important since it may will lead to identification of causal genetic factors which may offer alternative therapeutic strategies or prevention. ..
  14. CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMEN
    Rosalind Wright; Fiscal Year: 2003
    ..To our knowledge, this would be the first large-scale (N=64,000) longitudinal study of the association between a specific chronic life stressor (i.e., violence) and the incidence of asthma in adult women. ..
  15. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  16. Mouse Allergen and Asthma Intervention Trial
    Elizabeth Matsui; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  18. COLON CANCER SURVIVORS--MEDICATIONS & RISK OF RECURRENCE
    Christine Johnson; Fiscal Year: 2004
    ..Using automated pharmacy data, the timing of use and exposure to NSAIDs and HRT will be analyzed among cancer survivors, along with potentially confounding variables, in relation to these outcomes. ..
  19. Risk Factors for Non Hodgkin's Lymphoma in Twins
    Wendy Cozen; Fiscal Year: 2006
    ..6 and as high as 1.8. A matched case-control analysis using SAS will be performed using multivariate logistic regression. [unreadable] [unreadable]..
  20. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  21. Role of Mouse Allergen in Childhood Asthma
    Wanda Phipatanakul; Fiscal Year: 2007
    ..This will help her translate knowledge gained from her research into direct community benefit. [unreadable] [unreadable]..
  22. RISK FACTORS FOR YOUNG ADULT HODGKIN'S DISEASE IN TWINS
    Wendy Cozen; Fiscal Year: 2004
    ..6 and as high as 2.0 at 80% power. A matched case-control analysis will be performed using multivariate logistic regression in SAS. ..
  23. Rapid Test for Monitoring Dust Mite Avoidance in Homes
    Martin Chapman; Fiscal Year: 2004
    ..The Phase II project will result in the development of consumer based allergen tests that will improve asthma management using environmental control procedures. ..
  24. Tec inhibitors- A new therapeutic for allergic diseases
    Yuko Kawakami; Fiscal Year: 2003
    ..Since we have a screening method for searching for Tec inhibitors whose usefulness has been proven, we will also expand our search for better compounds. ..
  25. INNER CITY COCKROACH ALLERGEN REDUCTION TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ..Secondary variables, including medication use, acute care visits, school loss, FEVI and methacholine responsiveness will also be compared. ..
  26. HOME BASED ENVIRONMENTAL ADHERENCE TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ....
  27. Virus-Induced Mechanics of Altered Airway Responsiveness
    Michael Grunstein; Fiscal Year: 2008
    ..It is anticipated that the findings from these proposed studies would yield important new insights into the mechanistic interplay between viral respiratory pathogens, atopy, and altered airway responsiveness. [unreadable] [unreadable]..
  28. SIGNAL TRANSDUCTION IN SENSITIZED AIRWAY SMOOTH MUSCLE
    Michael Grunstein; Fiscal Year: 2002
    ....