bacterial adhesins

Summary

Summary: Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin.

Top Publications

  1. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
  2. ncbi X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli
    D Choudhury
    Department of Molecular Biology, Uppsala Biomedical Center, Swedish University of Agricultural Sciences, Box 590, S 753 24 Uppsala, Sweden
    Science 285:1061-6. 1999
  3. ncbi Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
  4. pmc Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
    Yok Ai Que
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    J Exp Med 201:1627-35. 2005
  5. pmc Serotypes, virulence genes, and intimin types of Shiga toxin (verotoxin)-producing Escherichia coli isolates from cattle in Spain and identification of a new intimin variant gene (eae-xi)
    M Blanco
    Departamento de Microbioloxia e Parasitoloxia, Facultade de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, Spain
    J Clin Microbiol 42:645-51. 2004
  6. ncbi Assembly of pili on the surface of Corynebacterium diphtheriae
    Hung Ton-That
    Committee on Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Mol Microbiol 50:1429-38. 2003
  7. ncbi Trimeric autotransporter adhesins: variable structure, common function
    Dirk Linke
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Proteinevolution, Spemannstr 35, 72076 Tubingen, Germany
    Trends Microbiol 14:264-70. 2006
  8. pmc PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosis
    Masaya Yamaguchi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:36272-9. 2008
  9. ncbi The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence
    A R Holmes
    Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand
    Mol Microbiol 41:1395-408. 2001
  10. pmc Serotypes, virulence genes, and intimin types of Shiga toxin (verotoxin)-producing Escherichia coli isolates from healthy sheep in Spain
    M Blanco
    Laboratorio de Referencia de E coli, Departamento de Microbioloxia e Parasitoloxia, Facultade de Veterinaria, Universidade de Santiago de Compostela USC, Campus de Lugo, 27002 Lugo, Spain
    J Clin Microbiol 41:1351-6. 2003

Detail Information

Publications285 found, 100 shown here

  1. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
    ....
  2. ncbi X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli
    D Choudhury
    Department of Molecular Biology, Uppsala Biomedical Center, Swedish University of Agricultural Sciences, Box 590, S 753 24 Uppsala, Sweden
    Science 285:1061-6. 1999
    ..A donor strand complementation mechanism in which the chaperone donates a strand to complete the pilin domain explains the basis for both chaperone function and pilus biogenesis...
  3. ncbi Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
    ....
  4. pmc Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
    Yok Ai Que
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    J Exp Med 201:1627-35. 2005
    ..Thus, fibrinogen and fibronectin binding could cooperate for S. aureus valve colonization and endothelial invasion in vivo...
  5. pmc Serotypes, virulence genes, and intimin types of Shiga toxin (verotoxin)-producing Escherichia coli isolates from cattle in Spain and identification of a new intimin variant gene (eae-xi)
    M Blanco
    Departamento de Microbioloxia e Parasitoloxia, Facultade de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, Spain
    J Clin Microbiol 42:645-51. 2004
    ..Thus, this study confirms that cattle are a major reservoir of STEC strains pathogenic for humans...
  6. ncbi Assembly of pili on the surface of Corynebacterium diphtheriae
    Hung Ton-That
    Committee on Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Mol Microbiol 50:1429-38. 2003
    ..This covalent tethering of adjacent pilin subunits appears to have evolved in many Gram-positive pathogens that encode sortase and pilin subunit genes with sorting signals and pilin motifs...
  7. ncbi Trimeric autotransporter adhesins: variable structure, common function
    Dirk Linke
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Proteinevolution, Spemannstr 35, 72076 Tubingen, Germany
    Trends Microbiol 14:264-70. 2006
    ..We propose that this repetitive arrangement facilitates recombination of domains to modulate the specificity of the common function: adhesion to the host...
  8. pmc PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosis
    Masaya Yamaguchi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:36272-9. 2008
    ..These results suggest that PfbA is an important factor in the development of pneumococcal infections...
  9. ncbi The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence
    A R Holmes
    Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand
    Mol Microbiol 41:1395-408. 2001
    ..Pneumococci adhere to glycosidic receptors on epithelial cells and to immobilized fibronectin, but the bacterial adhesins mediating these reactions are largely uncharacterized...
  10. pmc Serotypes, virulence genes, and intimin types of Shiga toxin (verotoxin)-producing Escherichia coli isolates from healthy sheep in Spain
    M Blanco
    Laboratorio de Referencia de E coli, Departamento de Microbioloxia e Parasitoloxia, Facultade de Veterinaria, Universidade de Santiago de Compostela USC, Campus de Lugo, 27002 Lugo, Spain
    J Clin Microbiol 41:1351-6. 2003
    ..Thus, this study confirms that healthy sheep are a major reservoir of STEC strains pathogenic for humans...
  11. ncbi Staphylococcus aureus fibronectin-binding protein (FnBP)-mediated adherence to platelets, and aggregation of platelets induced by FnBPA but not by FnBPB
    Christine Heilmann
    Institute of Medical Microbiology, University of Munster, Munster, Germany
    J Infect Dis 190:321-9. 2004
    ..The ability of Staphylococcus aureus to adhere to platelets and to induce aggregation of platelets is considered to be a critical factor in S. aureus-associated infective endocarditis...
  12. ncbi Adherence properties of Helicobacter pylori: impact on pathogenesis and adaptation to the host
    Stefan Odenbreit
    Max von Pettenkofer Institute for Hygiene und Medical Microbiology, Ludwig Maximilians University, Pettenkoferstr 9a, D 80336 Munich, Germany
    Int J Med Microbiol 295:317-24. 2005
    ..The aim of this review is to summarize recent data giving new insights in binding specificities of H. pylori adhesins and their role in pathogenesis and adaptation to the host...
  13. pmc Characterization of Shiga toxin-producing Escherichia coli strains isolated from human patients in Germany over a 3-year period
    Lothar Beutin
    Division of Microbial Toxins, Department of Biological Safety, Robert Koch Institute, D 13353 Berlin, Germany
    J Clin Microbiol 42:1099-108. 2004
    ..Our study indicates that different types of STEC strains predominate in infant and adult patients and that new types of STEC strains are present among human isolates...
  14. pmc The Moraxella catarrhalis porin-like outer membrane protein CD is an adhesin for human lung cells
    Melissa M Holm
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Infect Immun 72:1906-13. 2004
    ..This is the first report of M. catarrhalis ompCD mutants, and our findings demonstrate that this gene product is an adhesin for human lung cells...
  15. ncbi E-cadherin is a receptor for the common protein pneumococcal surface adhesin A (PsaA) of Streptococcus pneumoniae
    Julie M Anderton
    Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Bldg 18 B104, M S G 05, Atlanta, GA 30333, USA
    Microb Pathog 42:225-36. 2007
    ..nasopharyngeal (NP) epithelial cells in the first steps of nasopharyngeal carriage and colonization through bacterial adhesins. The pneumococcal surface adhesin A (PsaA) has previously been reported to play a significant role in ..
  16. pmc Moraxella catarrhalis strain O35E expresses two filamentous hemagglutinin-like proteins that mediate adherence to human epithelial cells
    Rachel Balder
    Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, 220 Riverbend Road, South Building Room 146, Athens, GA 30602, USA
    Infect Immun 75:2765-75. 2007
    ..The construction of isogenic mutants in the mhaB1 and mhaB2 genes of strain O35E also suggests that the MhaB proteins play distinct roles in M. catarrhalis adherence...
  17. ncbi Bacterial adhesins in host-microbe interactions
    Kimberly A Kline
    Swedish Institute for Infectious Disease Control and Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Cell Host Microbe 5:580-92. 2009
    ..In this review, we will focus on the interaction between bacterial adhesins and the host, with an emphasis on pilus-like structures.
  18. ncbi An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen
    Mark P Stevens
    Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, UK
    Mol Microbiol 46:649-59. 2002
    ..These findings indicate that the Bsa type III secretion system plays an essential role in modulating the intracellular behaviour of B. pseudomallei...
  19. ncbi An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets
    Barbara A Bensing
    Division of Infectious Diseases, Veterans Affairs Medical Center 111W and the University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Microbiol 44:1081-94. 2002
    ..The conserved organization of genes in the secY2-secA2 loci suggests that, in each of these Gram-positive species, SecA2 and SecY2 may constitute a specialized system for the transport of a very large serine-rich repeat protein...
  20. ncbi Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization
    Louise M O'Brien
    Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Cell Microbiol 4:759-70. 2002
    ..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
  21. ncbi Serotypes and virulence genes of bovine Shigatoxigenic Escherichia coli (STEC) isolated from a feedlot in Argentina
    Nora L Padola
    Laboratorio de Inmunoquimica y Biotecnologia, FCV, UNICEN, Pinto 399 7000 Tandil, Argentina
    Vet Microbiol 100:3-9. 2004
    ..This work provides new data for the understanding of the ecology of STEC in grain-fed cattle and confirms that cattle are an important reservoir of STEC...
  22. pmc Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection
    Jon S Blevins
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Microbiol 8:82. 2008
    ..burgdorferi to bind decorin has been hypothesized to be important for this disseminatory pathogenic strategy...
  23. ncbi Structural analysis of a novel anionic polysaccharide from Porphyromonas gingivalis strain W50 related to Arg-gingipain glycans
    Nikolay Paramonov
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Mol Microbiol 58:847-63. 2005
    ..This phosphorylated branched mannan represents a novel polysaccharide that is immunologically related to the post-translational additions of Arg-gingipains...
  24. ncbi Trimeric autotransporters: a distinct subfamily of autotransporter proteins
    Shane E Cotter
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Trends Microbiol 13:199-205. 2005
    ..We speculate that trimeric autotransporters evolved to enable high-affinity multivalent adhesive interactions with host surfaces and circulating host molecules to take place...
  25. pmc Emerging enteropathogenic Escherichia coli strains?
    Tania A T Gomes
    Departmento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil CEP 04023 062
    Emerg Infect Dis 10:1851-5. 2004
    ..Although diverse in phenotype and genotype, some strains are potentially diarrheagenic...
  26. pmc The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny
    Jason Gioia
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Bacteriol 188:7257-66. 2006
    ..haemolytica, Actinobacillus pleuropneumoniae, and Haemophilus ducreyi form a lineage distinct from other Pasteurellaceae. This observation was supported by a phylogenetic analysis using sequences of predicted housekeeping genes...
  27. pmc Characterization of Saa, a novel autoagglutinating adhesin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains that are virulent for humans
    A W Paton
    Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005, Australia
    Infect Immun 69:6999-7009. 2001
    ..Interestingly, Saa produced by other STEC strains ranges in size from 460 to 534 aa as a consequence of variation in the number of repeats and/or other insertions or deletions immediately proximal to the repeat domain...
  28. pmc The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil
    Rebecca Conners
    Department of Biochemistry, University of Bristol, Bristol, UK
    EMBO J 27:1779-89. 2008
    ..This explains how UspA1 can engage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respective cell surfaces during infection...
  29. pmc Bartonella adhesin a mediates a proangiogenic host cell response
    Tanja Riess
    Institut fur Medizinische Mikrobiologie und Hygiene, Eberhard Karls Universitat, Elfriede Aulhorn Strasse 6, 72076 Tubingen, Germany
    J Exp Med 200:1267-78. 2004
    ..Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders...
  30. pmc Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens
    T M Wizemann
    Laboratory of Molecular Infectious Diseases, The Rockefeller University, NY 10021, USA
    Proc Natl Acad Sci U S A 93:7985-90. 1996
    ..coli have MsrA activity. Together these data suggest that MsrA is required for the proper expression or maintenance of functional adhesins on the surfaces of these three major pathogenic bacteria...
  31. pmc Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    Jafar Mahdavi
    Department of Odontology Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 297:573-8. 2002
    Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H...
  32. pmc Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model
    Adam C Schaffer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 74:2145-53. 2006
    ..aureus nasal colonization in humans, which in turn may diminish the risk of staphylococcal infection. As targets for vaccine development and antimicrobial intervention are assessed, rodent nasal colonization models may be invaluable...
  33. pmc Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi
    Yanlin Shi
    Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803, USA
    Infect Immun 76:1239-46. 2008
    ..Taken together, the study results indicate that neither DbpA nor DbpB is essential for mammalian infection but that both are critical for the overall virulence of B. burgdorferi...
  34. pmc Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis
    Y A Que
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Infect Immun 69:6296-302. 2001
    ..Taken together, the present observations suggest that if antiadhesin therapy were to be developed, at least both of the clfA and fnbA products should be blocked for the therapy to be effective...
  35. ncbi Surface protein adhesins of Staphylococcus aureus
    T J Foster
    Microbiology Dept, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Trends Microbiol 6:484-8. 1998
    ..Adherence is mediated by surface protein adhesins (MSCRAMMs). Ligand binding by these fibronectin-, fibrinogen- and collagen-binding proteins occurs by distinct mechanisms that are being investigated at the molecular level...
  36. pmc Biofilm formation, icaADBC transcription, and polysaccharide intercellular adhesin synthesis by staphylococci in a device-related infection model
    Ursula Fluckiger
    Division of Infectious Diseases and Department of Research, University Hospital, Basel, Switzerland
    Infect Immun 73:1811-9. 2005
    ..In S. epidermidis, PIA expression is elevated and less vulnerable to environmental conditions...
  37. ncbi The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen
    E R Wann
    Center for Extracellular Matrix Biology, Department of Biochemistry and Biophysics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
    J Biol Chem 275:13863-71. 2000
    ..Finally, by overexpressing FnbpA in a mutant strain of S. aureus that lacks the expression of both ClfA and ClfB, we show that native FnbpA can mediate the interaction of S. aureus with soluble Fg...
  38. pmc Subtilisin-like autotransporter serves as maturation protease in a bacterial secretion pathway
    L Coutte
    INSERM U447, IBL, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    EMBO J 20:5040-8. 2001
    ..SphB1 is the first described subtilisin-like protein that serves as a specialized maturation protease in a secretion pathway of Gram-negative bacteria. This is reminiscent of pro-protein convertases of eukaryotic cells...
  39. pmc Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 195:221-31. 2002
    ..The induction of Tr1 cells after interaction of a pathogen-derived molecule with cells of the innate immune system represents a novel strategy exploited by an infectious pathogen to subvert protective immune responses in vivo...
  40. pmc The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation
    Xin Wang
    Department of Microbiology and Immunology, Emory University School of Medicine, 3105 Rollins Research Center, 1510 Clifton Road NE, Atlanta, GA 30322, USA
    J Bacteriol 186:2724-34. 2004
    ..The pgaABCD operon exhibits features of a horizontally transferred locus and is present in a variety of eubacteria. Therefore, we propose that PGA serves as an adhesin that stabilizes biofilms of E. coli and other bacteria...
  41. ncbi Strong association between shiga toxin-producing Escherichia coli O157 and virulence genes stx2 and eae as possible explanation for predominance of serogroup O157 in patients with haemolytic uraemic syndrome
    D Werber
    Department for Infectious Disease Epidemiology, Robert Koch Institut, Seestrasse 10, 13353 Berlin, Germany
    Eur J Clin Microbiol Infect Dis 22:726-30. 2003
    ..35). These data suggest that the more frequent carriage of both virulence genes, i.e. stx2 and eae, forms the basis of why STEC O157 predominates in patients with HUS...
  42. pmc Hag mediates adherence of Moraxella catarrhalis to ciliated human airway cells
    Rachel Balder
    Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia 30602, USA
    Infect Immun 77:4597-608. 2009
    ..These experiments conclusively demonstrate that the hag gene product is responsible for the previously unidentified tropism of M. catarrhalis for ciliated NHBE cells...
  43. ncbi YadA, the multifaceted Yersinia adhesin
    Y El Tahir
    Institute of Biomedicine, Department of Medical Biochemistry, University of Turku, Finland
    Int J Med Microbiol 291:209-18. 2001
    ..enterocolitica to induce the disease. Despite of this wealth of information or perhaps because of it, the in vivo role of YadA during infection remains still largely unresolved...
  44. pmc Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection
    S Alonso
    INSERM U447, IBL, Institut Pasteur de Lille, F-59019 Lille, France
    Infect Immun 69:6038-43. 2001
    ..This may lead to damage of the pulmonary epithelium, allowing the bacteria to colonize even in the absence of FHA...
  45. ncbi Bacterial pathogenesis: exploiting cellular adherence
    Erin C Boyle
    Department of Microbiology and Immunology, Biotechnology Laboratory, Wesbrook Building, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Curr Opin Cell Biol 15:633-9. 2003
    ..Recent studies have contributed to our understanding of bacterial adherence mechanisms and the consequences of receptor engagement; they have also highlighted alternative functions of cell adhesion molecules...
  46. ncbi Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)
    Yue Qing Zhang
    Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, China
    Mol Microbiol 49:1577-93. 2003
    ..No mec genes, IS256, IS257, were found in ATCC 12228. It is suggested that the absence of the ica operon is a genetic marker in commensal Staphylococcus epidermidis strains which are less likely to become invasive...
  47. pmc Identification of a Moraxella catarrhalis outer membrane protein exhibiting both adhesin and lipolytic activities
    Jennifer M Timpe
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Infect Immun 71:4341-50. 2003
    ..The construction and characterization of isogenic M. catarrhalis O35E mutants demonstrated that the lack of McaP expression abolishes esterase activity and considerably decreases adherence to several human cell lines...
  48. pmc Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus
    Sharon J Peacock
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, United Kingdom
    Infect Immun 70:4987-96. 2002
    ..Our findings also suggested that allelic variants of a polymorphic locus can make different contributions to the disease process, further study of which is likely to expand our understanding of staphylococcal disease pathogenesis...
  49. pmc Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus
    Jon S Blevins
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 70:470-80. 2002
    ..Taken together, these results suggest that studies defining the regulatory roles of sarA and agr by using RN6390 are not always representative of the events that occur in clinical isolates of S. aureus...
  50. ncbi Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus
    Christof R Hauck
    Zentrum für Infektionsforschung and Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Microbiol 9:5-11. 2006
    ..Understanding the invasive capacity of S. aureus should open up new avenues to control this microorganism in diverse disease settings...
  51. ncbi Interaction between host gastric Sialyl-Lewis X and H. pylori SabA enhances H. pylori density in patients lacking gastric Lewis B antigen
    Bor Shyang Sheu
    Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Am J Gastroenterol 101:36-44. 2006
    ..We tested whether the interaction between host gastric Le(x) antigen and the SabA protein of H. pylori determined gastric colonization density...
  52. pmc Contribution of sialic acid-binding adhesin to pathogenesis of experimental endocarditis caused by Streptococcus gordonii DL1
    Yukihiro Takahashi
    Department of Microbiology, Nippon Dental University School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Infect Immun 74:740-3. 2006
    ....
  53. pmc The Moraxella catarrhalis autotransporter McaP is a conserved surface protein that mediates adherence to human epithelial cells through its N-terminal passenger domain
    Serena L Lipski
    Department of Medical Microbiology and Immunology, University of Toledo Health Sciences Campus, 3055 Arlington Avenue, Toledo, Ohio 43614, USA
    Infect Immun 75:314-24. 2007
    ..catarrhalis to A549 human lung cells by up to 47% and to reduce binding of recombinant E. coli expressing McaP by 98%. These results suggest that McaP should be considered as a potential vaccine antigen...
  54. ncbi Fibronectin-binding activity in Borrelia burgdorferi1
    D J Grab
    Department of Parasitology, Tulane Regional Primate Research Center, Covington, LA, USA
    Biochim Biophys Acta 1407:135-45. 1998
    ..turicatae (39, 41, 45, 50, 56, 59 and 66 kDa). Preliminary evidence suggests that fibronectin (and Fn-BA) may play a role as a molecular bridge between the spirochete and other components of the extracellular matrix...
  55. pmc Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen
    Henry A Choy
    Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Infect Immun 75:2441-50. 2007
    ..The characterization of the Lig adhesin function should aid the design of Lig-based vaccines and serodiagnostic tests...
  56. ncbi Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis
    Mitsunori Yamada
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    FEMS Microbiol Lett 250:271-7. 2005
    ..gingivalis. The major fimbriae and Arg-gingipain B of P. gingivalis also play important roles in biofilm formation with T. denticola...
  57. pmc The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha
    Barbara A Bensing
    Division of Infectious Diseases, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Infect Immun 72:6528-37. 2004
    ..The combined results indicate that GspB and Hsa contribute similar binding capabilities to M99 and Challis, respectively, but there may be subtle differences in the preferred epitopes to which these adhesins bind...
  58. pmc The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides
    Jyoti Mathur
    Department of Immunology, Sackler School of Biomedical Sciences, Tufts University School of Medicine, and Howard Hughes Medical Institute, Boston, Massachusetts 02111, USA
    Infect Immun 72:3577-83. 2004
    ..cholerae is not attributable to a generally defective outer membrane...
  59. pmc Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks
    K E Hagman
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Infect Immun 68:4759-64. 2000
    ..The failure of DbpA immunization to protect tick-challenged mice contradicts the results of earlier needle inoculation vaccination experiments and suggests that DbpA may not be suitable as a Lyme disease vaccine...
  60. pmc The Yersinia pestis Ail protein mediates binding and Yop delivery to host cells required for plague virulence
    Suleyman Felek
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Infect Immun 77:825-36. 2009
    ..Thus, the Ail protein is critical for both Y. pestis type III secretion in vitro and infection in mice...
  61. ncbi The characterization of functions involved in the establishment and maturation of Klebsiella pneumoniae in vitro biofilm reveals dual roles for surface exopolysaccharides
    Damien Balestrino
    Laboratoire de Bacteriologie, Université d Auvergne Clermont1, Faculte de Pharmacie, Clermont Ferrand, 63000 Clermont Ferrand, France
    Environ Microbiol 10:685-701. 2008
    ..These results give new insight into the bacterial factors sequentially associated with the ability to colonize an abiotic surface and reveal the dual roles played by surface exopolysaccharides during K. pneumoniae biofilm formation...
  62. pmc Extracellular adherence protein from Staphylococcus aureus enhances internalization into eukaryotic cells
    Axana Haggar
    Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Infect Immun 71:2310-7. 2003
    ..aureus into eukaryotic cells. We therefore propose a novel internalization pathway for S. aureus in which Eap plays an enhancing role...
  63. pmc Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin
    B Spellerberg
    Institute of Medical Microbiology, University Hospital Aachen, D 52057 Aachen, Germany
    Infect Immun 67:871-8. 1999
    ..These results indicate that Lmb mediates the attachment of S. agalactiae to human laminin, which may be essential for the bacterial colonization of damaged epithelium and translocation of bacteria into the bloodstream...
  64. pmc The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein
    P W O'Toole
    Astra Arcus AB, Sodertalje, Sweden
    J Bacteriol 177:6049-57. 1995
    ..The data collectively suggest that HpaA is a nonessential lipoprotein internal to the H. pylori cell and that it is not involved in adhesion...
  65. pmc Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection
    Andrea Kropec
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Immun 73:6868-76. 2005
    ..Thus, PNAG confers on S. aureus resistance to killing mediated by these innate host immune mediators. Overall, PNAG production by S. aureus appears to be a critical virulence factor as assessed in murine models of systemic infection...
  66. ncbi Structural basis for the function of stringent starvation protein a as a transcription factor
    Anne Marie Hansen
    Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 280:17380-91. 2005
    ..SspA orthologs from Y. pestis, Vibrio cholerae, and Pseudomonas aeruginosa are all functional in acid resistance of E. coli, whereas only Y. pestis SspA supports phage P1 growth...
  67. ncbi Citrobacter rodentium of mice and man
    Rosanna Mundy
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London SW7 2AZ, UK
    Cell Microbiol 7:1697-706. 2005
    ..Here we review the literature of C. rodentium from its emergence in the mid-1960s to the most contemporary reports of colonization, pathogenesis, transmission and immunity...
  68. ncbi Virulence genotypes and serotypes of verotoxigenic Escherichia coli isolated from cattle and foods in Argentina. Importance in public health
    A E Parma
    Laboratorio de Inmunoquimica y Biotecnologia, FCV, UNICEN, Tandil, Argentina
    Eur J Epidemiol 16:757-62. 2000
    ..In addition, this study affirms the advantages of PCR-based screening of E. coli isolates given the finding of so many verotoxin-producing strains...
  69. ncbi Antimicrobial resistance of Shiga toxin (verotoxin)-producing Escherichia coli O157:H7 and non-O157 strains isolated from humans, cattle, sheep and food in Spain
    Azucena Mora
    Laboratorio de Referencia de E coli LREC, Departamento de Microbioloxia e Parasitoloxia, Facultade de Veterinaria, Universidade de Santiago de Compostela USC, Lugo, Spain
    Res Microbiol 156:793-806. 2005
    ..We conclude that the high prevalence of antimicrobial resistance detected in our study is a source of concern, and cautious use of antibiotics in animals is highly recommended...
  70. pmc Functional analysis of antigen 43 in uropathogenic Escherichia coli reveals a role in long-term persistence in the urinary tract
    Glen C Ulett
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Infect Immun 75:3233-44. 2007
    ..Our findings demonstrate that Ag43a contributes to UPEC disease pathogenesis and reveal that there are pathogenicity-adapted variants of Ag43 with distinct virulence-related functions...
  71. ncbi Fibronectin-binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcgammaRIIa receptor
    J Ross Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Mol Microbiol 59:212-30. 2006
    ..This suggests new avenues for development of therapeutics against vascular infections...
  72. ncbi Initial binding of Shiga toxin-producing Escherichia coli to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages
    F Ebel
    Institut fur Medizinische Mikrobiologie, Justus Liebig Universitat, Giessen, Germany
    Mol Microbiol 30:147-61. 1998
    ....
  73. ncbi Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge
    Lloyd Rose
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Infect Dis 198:375-83. 2008
    ..We conclude that PsrP is an adhesin required for bacterial persistence in the lungs and that rPsrP(SRR1-BR) is a protective antigen...
  74. ncbi Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor
    James F Sinclair
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 279:33751-8. 2004
    ..Taken together, these findings suggest that nucleolin is involved in bacterial adherence promoted by all intimin types and that Tir and nucleolin compete for intimin during adherence...
  75. ncbi Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic Escherichia coli O157:H7
    James F Sinclair
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Biol Chem 277:2876-85. 2002
    ..Finally, we demonstrated that mouse anti-nucleolin sera significantly decreased the adherence of EHEC O157:H7 to HEp-2 cells. From this, we conclude that nucleolin is the HEp-2 cell receptor for intimin-gamma expressed by EHEC O157:H7...
  76. pmc Internalization of Staphylococcus aureus by human corneal epithelial cells: role of bacterial fibronectin-binding protein and host cell factors
    Bradley D Jett
    Department of Biology, Oklahoma Baptist University, Shawnee 74804, USA
    Infect Immun 70:4697-700. 2002
    ..These data suggest that FnBPs play a key role in host-parasite interactions and may serve as an important adhesin or invasin in ulcerative keratitis caused by S. aureus...
  77. pmc Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination
    Qilong Xu
    Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803, USA
    Infect Immun 75:4272-81. 2007
    ..Taken together, the study highlights the importance of controlling surface antigen expression in the infectivity, dissemination, tissue colonization, pathogenicity, and persistence of B. burgdorferi during mammalian infection...
  78. ncbi The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain
    Neeraj K Surana
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:14679-85. 2004
    ..YadA and Neisseria meningitidis NhhA are translocation-competent. These data provide experimental support for a unique subclass of autotransporters characterized by a short trimeric translocator domain...
  79. ncbi Yersinia outer protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-kappa B pathway and exploits lipopolysaccharide signaling to trigger apoptosis in macrophages
    K Ruckdeschel
    , , Germany
    J Immunol 166:1823-31. 2001
    ..This reflects a strategy of a bacterial pathogen that takes advantage of LPS, serving as cofactor, to impair the macrophage...
  80. pmc Common accessory genes for the Bordetella pertussis filamentous hemagglutinin and fimbriae share sequence similarities with the papC and papD gene families
    C Locht
    Laboratoire de Microbiologie Génétique et Moléculaire, INSERM CJF91 09, Lille, France
    EMBO J 11:3175-83. 1992
    ..Deletion analyses suggest that fhaB and the downstream genes can be transcribed as a polycistronic operon, and primer extension analysis revealed the presence of a second promoter between fhaB and fhaD...
  81. ncbi Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix
    Felipe C Cabello
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Trends Microbiol 15:350-4. 2007
    ..burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved...
  82. ncbi Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface
    C Heilmann
    Institut fur Medizinische Mikrobiologie, Munster, Germany
    Mol Microbiol 24:1013-24. 1997
    ..Our findings provide evidence for a new function of an autolysin (AtlE) in mediating the attachment of bacterial cells to a polymer surface, representing the prerequisite for biofilm formation...
  83. ncbi A novel type of two-component regulatory system affecting gingipains in Porphyromonas gingivalis
    Yoshiaki Hasegawa
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    Microbiol Immunol 47:849-58. 2003
    ..The gene encoding the sensor histidine kinase was designated gppX, which represents regulation (X) of gingipains and black pigmentation in P. gingivalis...
  84. pmc Human infections with Shiga toxin-producing Escherichia coli other than serogroup O157 in Germany
    L Beutin
    Robert Koch Institut, Abt Mikrobiologie, Berlin, Germany
    Emerg Infect Dis 4:635-9. 1998
    ..EaeA-negative STEC were found in 35 (39.3%) of the patients and were more associated with clinically uncomplicated cases and adult patients. For pediatric patients, a serotype-independent diagnosis of STEC is recommended...
  85. ncbi The outer membrane protein, antigen 43, mediates cell-to-cell interactions within Escherichia coli biofilms
    P N Danese
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    Mol Microbiol 37:424-32. 2000
    ..Altogether, our results suggest that E. coli uses both common and specific gene sets for the development of biofilms under various growth conditions...
  86. ncbi Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients
    Chariya Chomvarin
    Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Infect Dis 12:30-6. 2008
    ....
  87. ncbi Virulence genes and intimin types of Shiga-toxin-producing Escherichia coli isolated from cattle and beef products in Argentina
    Miguel Blanco
    E coli Reference Laboratory LREC, Department of Microbiology and Parasitology, Faculty of Veterinary, University of Santiago de Compostela, Lugo, Spain
    Int Microbiol 7:269-76. 2004
    ..The serotypes O120:H19 and O185:H7 were not previously reported in bovine STEC...
  88. ncbi Bacterial adhesins: function and structure
    P Klemm
    Department of Microbiology, Technical University of Denmark, Lyngby
    Int J Med Microbiol 290:27-35. 2000
    ..A detailed picture of how bacteria are able to target to various receptors is emerging. A large number of bacterial adhesins with individual receptor specificities have been identified...
  89. pmc Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves
    E A Dean-Nystrom
    Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010, USA
    Infect Immun 66:4560-3. 1998
    ..These results suggest that experiments to determine if intimin-based vaccines reduce O157:H7 levels in cattle are warranted...
  90. pmc Recycling of Shiga toxin 2 genes in sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM
    Alexander Mellmann
    Institute of Hygiene, University of Munster, Robert Koch Str 41, 48149 Munster, Germany
    Appl Environ Microbiol 74:67-72. 2008
    ..The ability to recycle stx(2), a critical virulence trait, makes SF E. coli O157:NM strains ephemeral EHEC that can exist as stx-negative variants during certain phases of their life cycle...
  91. ncbi Horizontal gene transfer and host specificity of beta-haemolytic streptococci: the role of a putative composite transposon containing scpB and lmb
    C Franken
    Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Mol Microbiol 41:925-35. 2001
    ..pyogenes, S. agalactiae and group C and G streptococcal strains to colonize or infect human hosts is dependent on their presence...
  92. ncbi Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) Tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modifications
    B Kenny
    Department of Pathology and Microbiology, School of Medical Sciences, Bristol, UK
    Mol Microbiol 31:1229-41. 1999
    ..The data also suggest a mechanism for Tir insertion into the host membrane, as well as providing clues to the mode of intimin-integrin interaction...
  93. pmc Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium
    M Ghaem-Maghami
    Centre for Molecular Microbiology and Infection, Department of Biochemistry, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, United Kingdom
    Infect Immun 69:5597-605. 2001
    ..These results show that anti-intimin immune responses can modulate the outcome of a C. rodentium infection and support the use of intimin as a component of a type-specific EPEC or EHEC vaccine...
  94. ncbi Sequential autolytic processing activates the zymogen of Arg-gingipain
    Jowita Mikolajczyk
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:10458-64. 2003
    ..Each step in activation requires the previous step, and an affinity probe reveals that incremental activity enhancements are achieved in a stepwise manner...
  95. ncbi Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
    J Seshu
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Science Center, 407 Reynolds Medical Building, College Station, 77843, USA
    Mol Microbiol 59:1591-601. 2006
    ..burgdorferi-specific pathogenic mechanisms, particularly in the context of dissemination, secondary colonization and/or persistence...
  96. pmc Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa
    Stephanie Perret
    Centre de Recherches sur les Macromolecules Vegetales, CNRS, Universite Joseph Fourier, BP53, 38041 Grenoble Cedex 09, France
    Biochem J 389:325-32. 2005
    ..This study provides important structural information about compounds that could be of general application in new therapeutic strategies against bacterial infections...
  97. pmc Truncation of fibronectin-binding proteins in Staphylococcus aureus strain Newman leads to deficient adherence and host cell invasion due to loss of the cell wall anchor function
    Matthias Grundmeier
    Institute of Medical Microbiology, University of Munster, Domagkstrasse 10, D 48149 Munster, Germany
    Infect Immun 72:7155-63. 2004
    ..This mutation may explain some of the earlier reported conflicting data with strain Newman. Thus, care should be taken when drawing negative conclusions about the role of FnBPs as a virulence factor in a given model...
  98. ncbi Pathogenesis of streptococcal and staphylococcal endocarditis
    Philippe Moreillon
    Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, BH19 Rue du Bugnon, 1011 Lausanne, Switzerland
    Infect Dis Clin North Am 16:297-318. 2002
    ..Streptococci produce surface glucans (gtf and ftf), ECM adhesins (e.g., fibronectin-binding proteins, FimA), and platelet aggregating factors (phase I and phase II antigens, pblA, pblB, and pblT), all of which have been...
  99. ncbi Bacterial adhesion to target cells enhanced by shear force
    Wendy E Thomas
    Department of Bioengineering, 98195, Seattle, WA, USA
    Cell 109:913-23. 2002
    ..The ability of FimH to function as a force sensor provides a molecular mechanism for discrimination between surface-exposed and soluble receptor molecules...
  100. ncbi Streptococcus agalactiae invasion of human brain microvascular endothelial cells is promoted by the laminin-binding protein Lmb
    Tobias Tenenbaum
    Pädiatrische Infektiologie, Klinik fur Allgemeine Padiatrie, Universitatsklinikum Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Microbes Infect 9:714-20. 2007
    ..Taken together, our studies support the conclusion that Lmb promotes invasion of S. agalactiae into HBMEC but does not play a role in IL-8 release from HBMEC...
  101. ncbi Virulence genes of Shiga toxin-producing Escherichia coli isolated from food, animals and humans
    J Meng
    Department of Nutrition and Food Science, University of Maryland, College Park 20742, USA
    Int J Food Microbiol 45:229-35. 1998
    ..Results suggest that a combination of EHEC-hlyA and eae genes could serve as markers to differentiate EHEC from less pathogenic STEC, and other pathogenic or non-pathogenic E. coli...

Research Grants62

  1. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    ..tested vaccine candidates for the prevention of NTHI-induced OM that have been derived from primarily two bacterial adhesins/virulence determinants: the OMP P5-homologous adhesin (or OMP P5) and the type IV twitching pilus (or Tfp)...
  2. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..actinomycetemcomitans. A long term goal of the proposed research is to identify and characterize bacterial adhesins that are required for the colonization of the oral cavity and non-oral tissues...
  3. Determining vaccine candidacy of LT and STa toxoid fusions against enterotoxigeni
    Weiping Zhang; Fiscal Year: 2010
    ..The key virulence factors in ETEC- associated diarrhea are bacterial adhesins or colonization factor antigens (CFAs) and enterotoxins...
  4. Training in structural biology &glycobiology
    Hui Wu; Fiscal Year: 2012
    ..protein (Fap1) in a model organism, Streptococcus parasanguinis have revealed a new family of bacterial adhesins, serine-rich repeat glycoproteins (SRRPs)...
  5. ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTION
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..We will evaluate the ability of these nanoparticles to prevent and treat UTI. ..
  6. STRUCTURE OF ORAL BACTERIAL ADHESINS
    Teresa Ruiz; Fiscal Year: 2012
    ..We will determine the 3D structure of the adhesins and adhesin/receptor complexes, which is essential to gain insights into the different stages of the pathogenic process. ..
  7. GENETIC ANALYSIS OF TOXINOGENESIS IN VIBRIO CHOLERAE
    JOHN JOSEPH MEKALANOS; Fiscal Year: 2013
    ..These machines allow V. cholerae to puncture human cells and then inject into them toxic proteins. Many other bacteria express T3SS and T6SS and thus they exciting new targets for development of drugs and vaccines. ..
  8. Mechanisms of amyloid nucleation
    RONALD B WETZEL; Fiscal Year: 2013
    ..cases amyloid fibril formation is beneficial and necessary for a particular biological function, such as the bacterial adhesins that support biofilm growth, and the secretory storage granules used by mammals for storage and release of ..
  9. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott Hultgren; Fiscal Year: 2007
    ..This work will lead to a molecular under standing of the bioactivities of defined cranberry constituents on UPEC pathogenesis and may lead to better treatments for UTIs. ..
  10. Structural Interactions of Bacterial Adhesin with Glycosaminoglycans
    Xu Wang; Fiscal Year: 2010
    ..strives to overcome this deficiency by conducting an in-depth structural study of the interactions between bacterial adhesins and glycosaminoglycans (GAGs), a ubiquitous polysaccharide found on the surface of cells and a primary ..
  11. Mechanisms of Pneumococcal Adherence
    SAMANTHA JANE KING; Fiscal Year: 2012
    ..Our increased understanding of pneumococcal adherence will help us achieve the longer term goal of developing a more effective vaccine or treatment to reduce the burden of pneumococcal disease. ..
  12. Structural Interactions of Bacterial Adhesin with Glycosaminoglycans
    Xu Wang; Fiscal Year: 2013
    ..strives to overcome this deficiency by conducting an in-depth structural study of the interactions between bacterial adhesins and glycosaminoglycans (GAGs), a ubiquitous polysaccharide found on the surface of cells and a primary ..
  13. CLONING AND PURIFICATION OF A VEILLONELLA ADHESIN
    Christopher Hughes; Fiscal Year: 1993
    ..confirm the role of this molecule in adherence, enable us to compare its primary structure to other known bacterial adhesins and introduce it into the more easily manipulated genetic background of E. coli...
  14. STRUCTURE OF THE RECEPTORS FOR ORAL BACTERIAL ADHESINS
    C Bush; Fiscal Year: 1991
    ....
  15. HAEMOPHILUS--RAMIFICATIONS OF PILUS MEDIATED ADHERENCE
    GRAHAM KRASAN; Fiscal Year: 2004
    ..of the upper respiratory tract is an essential event in the pathogenesis of disease and is facilitated by bacterial adhesins that recognize specific receptors motifs on eukaryotic cells...
  16. ADHERENCE OF BORDETELLA PERTUSSIS TO CELLS
    Elaine Tuomanen; Fiscal Year: 2000
    ..A profound structural and functional mimicry between these bacterial adhesins and the human adhesion molecules critical to leukocyte trafficking were then discovered...
  17. Functional Analysis of a Streptococcal GPIb Adhesin
    Hui Wu; Fiscal Year: 2007
    ..Little is known about mechanisms how bacterial adhesins interact with human platelets...
  18. STREPTOCOCCUS PNEUMONIAE ADHERENCE AND OTITIS MEDIA PATH
    Thomas Demaria; Fiscal Year: 2004
    ..These studies may suggest avenues for blocking interaction of Spn with host cells either by immunization or direct intervention blockade with isolated receptor moieties or bacterial adhesin components. ..
  19. INTESTINAL PROTEIN METABOLISM AND FUNCTION
    David Alpers; Fiscal Year: 2000
    ..3) explore the binding of bacterial adhesins to SLP. 4) identify cDNA clones encoding rat SLP proteins...
  20. Antigenic switch in bacterial adhesins
    EVGENI VENIAMINOVIC SOKURENKO; Fiscal Year: 2013
    ..We intend to analyze the conformational switch in FimH in the context of the immune response against the adhesive protein. ..
  21. MOLECULAR BASIS OF E. COLI COLONIZATION
    Paul Cohen; Fiscal Year: 1990
    ..In part two, the receptors and bacterial adhesins responsible for in vitro adhesion to mucus and epithelial cell brush borders will be identified, purified ..
  22. BACTERIAL ADHESION TO DENTIN IN ROOT SURFACE CARIES
    LECH SWITALSKI; Fiscal Year: 1993
    ..indirectly, in the etiology of root surface caries, attach to the tissue via specific interactions involving bacterial adhesins on one side and components of the dentin on the other...
  23. MOLECULAR MECHANISM OF PSEUDOMONAS INVASION OF CELLS
    BARBARA KAZMIERCZAK; Fiscal Year: 2001
    ..aeruginosa infections. The bacterial adhesins and invasins identified by this approach will be excellent targets for novel anti-pseudomonal therapies; ..
  24. Low birth weight, uterine infection, and nitric oxide
    Chandrasekhar Yallampalli; Fiscal Year: 2007
    ..including Escherichia coil, develop unique virulence mechanisms to colonize and invade the urogenital tract Bacterial adhesins such as Dr fimbriae of E col interact with host tissue receptors allowing ascending infection and associated ..
  25. Biochemical Role of Airway Mucins in Cystic Fibrosis
    GOVERDHAN SACHDEV; Fiscal Year: 2003
    ..Mucins provide protection to epithelia through interaction of their saccharides with bacterial adhesins. Chronic colonization with Pseudomonas aeruginosa, is considered the principal cause of death in CF patients...
  26. GENETIC ANALYSIS OF GBS ADHERENCE TO FIBRONECTIN
    GLEN TAMURA; Fiscal Year: 2002
    ..These studies will allow for identification of the structural gene(s) for fibronectin adhesin(s). ..
  27. Pathogenesis of Campylobacter enteritis:
    MICHAEL KONKEL; Fiscal Year: 2005
    ..jejuni, and will be useful in the development of intervention and control methods to reduce the number of cases of human campylobacteriosis. ..
  28. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2008
    ..The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training. [unreadable] [unreadable]..
  29. P. gingivalis Capsule in Cell Inflammation
    Frank Gibson; Fiscal Year: 2007
    ..We will characterize the host cellular inflammatory response to purified P. gingivalis capsular polysaccharide and begin to define the innate immune responses that govern leukocyte recruitment. ..
  30. STAPHYLOCOCCUS AUREUS FIBRONECTIN-BINDING ADHESINS
    Barbara Menzies; Fiscal Year: 2003
    ..The use of FnBP as an anti-adhesin presents a novel therapeutic tool for the prevention of S. aureus infections. ..
  31. IInfection-Elicited Oral Bone Loss: TLR2, Ontogency, and Porphromonas Gingivalis
    Frank C Gibson; Fiscal Year: 2010
    ..These studies provide for a thorough examination of the mechanisms underlying the role played by specific TLR receptors to P. gingivalis-elicited inflammation and oral bone loss in the context of age. ..
  32. Immunopathogenesis of Human Granulocytic Anaplasmosis
    Erol Fikrig; Fiscal Year: 2008
    ..phagocytophilum are important in infection, delineate the similarities and differences between infection in the arthropod vector and mammalian host, and lead to new strategies to interfere with the Anaplasma life cycle. ..
  33. MAST CELLS IN INNATE IMMUNITY AGAINST BACTERIAL INFECTIO
    Ravi Malaviya; Fiscal Year: 2001
    ..These studies will provide new insights regarding the participation of mast cells in innate host defense against pathogenic gram negative bacteria. ..
  34. Helicobacter hepaticus: pathogenesis of inflammatory bowel disease
    David Schauer; Fiscal Year: 2008
    ..hepaticus. ..
  35. Genetica Analysis of S. Pyogenes Virulence Factors
    JUNE SCOTT; Fiscal Year: 2008
    ..This will suggest new targets for development of therapeutic interventions to prevent and/or ameliorate the many types of GAS diseases. ..
  36. Mechanism that regulate Helicobacter pylori-induced beta-caterin activation
    Richard Peek; Fiscal Year: 2009
    ..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  37. 2008 Bacterial Cell Surfaces Gordon Research Conference
    ANNE DELCOUR; Fiscal Year: 2008
    ..Success in these research endeavors is enhanced by the exchange of information and ideas promoted by the Bacterial Cell Surfaces Gordon Conference. [unreadable] [unreadable] [unreadable]..
  38. The Structural Basis of Eukaryotic Replication Origin Licensing by Cryo-EM
    Huilin Li; Fiscal Year: 2010
    ..These detailed structural studies will provide a long-awaited molecular mechanism for the origin licensing stage of the intricate replication initiation process. ..
  39. H. hepaticus: the pathogenesis of IBD
    David Schauer; Fiscal Year: 2007
    ..It is hoped that these studies will lead to the development of new strategies for the treatment and the prevention of IBD. ..
  40. Intergeneric Signaling Molecules of S. cristatus
    Hua Xie; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  41. Ninth International Congress on Toxoplasmosis
    Boris Striepen; Fiscal Year: 2007
    ..gondii that is not often seen in fields as high paced and[unreadable] competitive and has facilitated rapid and sustained progress in research on this pathogen[unreadable] and related parasites. ..
  42. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  43. Type IV Pilins as Vaccines against Bioterrorism Threats
    Michael Donnenberg; Fiscal Year: 2004
    ....
  44. SALMONELLA TYPE 3 SECRETION SYSTEM FOR ANTIGEN DELIVERY
    JORGE GALAN; Fiscal Year: 2004
    ..This will significantly broaden the utility of avirulent strains of Salmonella as platforms for the development of polyvalent vaccines. ..
  45. IL-1 and IL-1ra Stimulation of S aureus Replication
    SIVADASAN KANANGAT; Fiscal Year: 2003
    ..A better understanding of how bacteria such as S. aureus use IL-1 family of cytokines to replicate and defeat the host defense is highly relevant to the study of septic arthritis. ..
  46. MOLECULAR PROPERTIES AND MODULATION OF BACTERIAL PORINS
    ANNE DELCOUR; Fiscal Year: 2003
    ..This information on the three-dimensional structure of porins will be extremely valuable for the design of genetically engineered channels and the meaningful interpretation of the data. ..
  47. MECHANISMS REGULATING FIBRONECTIN DEPOSITION
    Jane Sottile; Fiscal Year: 2003
    ....
  48. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  49. Seventh International Symposium on Pertussis
    Erik Hewlett; Fiscal Year: 2002
    ..This meeting will lead to a greater scientific understanding of the biology of this organism, and the promise for developing a more effective means to control this disease. ..
  50. Oral spirochetes: molecular genetic analysis
    Ashu Sharma; Fiscal Year: 2004
    ..pallidum, may play a role in periodontitis will be examined. These approaches should increase understanding of the molecular basis for the pathogenicity of spirochetes. ..
  51. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
  52. Molecular characterization of M. marinum biofilms
    LUCIA BARKER; Fiscal Year: 2005
    ....
  53. Mechanisms and Effects of Fibronectin Matrix Remodeling
    Jane Sottile; Fiscal Year: 2007
    ....
  54. Probiotic Lactobacilli and Vaginal Epithelium
    Ann Stapleton; Fiscal Year: 2007
    ....
  55. 8th International Symposium - Saga of the Genus Bordetella, 1906-2006
    Erik Hewlett; Fiscal Year: 2006
    ..unreadable] The bordetella community is an especially open and collaborative[unreadable] collection of scientists and it is important to assure and support[unreadable] attendance of trainees at meetings such as this. ..
  56. Toll-like receptor responses to West Nile virus
    Erol Fikrig; Fiscal Year: 2007
    ..These studies should increase our understanding of the role of TLR3 in viral recognition, and may lead to new strategies to prevent, or treat, WN virus infection. [unreadable] [unreadable]..
  57. 2006 Periodontal Diseases Gordon Research Conference
    Michael Curtis; Fiscal Year: 2006
    ..Funding is requested in order to support the travel costs and meeting expenses of speakers and to provide meeting grants for junior research workers at the beginning of their research careers. [unreadable] [unreadable] [unreadable]..
  58. Regulation of Human Beta-Defensins in Epithelia
    WHASUN CHUNG; Fiscal Year: 2006
    ..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
  59. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  60. INTERLEUKIN-12 REGULATION BY DR-FIMBRIATED E. COLI
    Pawel Goluszko; Fiscal Year: 2002
    ..The investigators propose to evaluate in three Specific Aims the general hypothesis that cross-linking of DAF on human monocytes/macrophages by E. coli bearing Dr fimbriae inhibits IL-2 production. ..