bacterial antigens

Summary

Summary: Substances elaborated by bacteria that have antigenic activity.

Top Publications

  1. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
  2. ncbi Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
    Alexander S Pym
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Mol Microbiol 46:709-17. 2002
  3. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
  4. ncbi Helicobacter exploits integrin for type IV secretion and kinase activation
    Terry Kwok
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nature 449:862-6. 2007
  5. pmc A universal vaccine for serogroup B meningococcus
    Marzia M Giuliani
    Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy
    Proc Natl Acad Sci U S A 103:10834-9. 2006
  6. ncbi Facing the crisis: improving the diagnosis of tuberculosis in the HIV era
    Mark D Perkins
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    J Infect Dis 196:S15-27. 2007
  7. pmc Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection
    Loic Coutte
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America
    PLoS Pathog 5:e1000293. 2009
  8. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
  9. pmc Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
    Naomi Ohnishi
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Health Administration Center, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 105:1003-8. 2008
  10. ncbi Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
    G Vitale
    Dipartimento di Scienze Biomediche, Universita di Padova, Italy
    Biochem Biophys Res Commun 248:706-11. 1998

Detail Information

Publications300 found, 100 shown here

  1. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  2. ncbi Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
    Alexander S Pym
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Mol Microbiol 46:709-17. 2002
    ..Knocking-in five other RD loci did not affect the virulence of BCG. This study describes a genetic lesion that contributes to safety and opens new avenues for vaccine development...
  3. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    ..These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague...
  4. ncbi Helicobacter exploits integrin for type IV secretion and kinase activation
    Terry Kwok
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nature 449:862-6. 2007
    ..Our findings provide insights into the role of integrins in H.-pylori-induced pathogenesis. CagL may be exploited as a new molecular tool for our further understanding of integrin signalling...
  5. pmc A universal vaccine for serogroup B meningococcus
    Marzia M Giuliani
    Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy
    Proc Natl Acad Sci U S A 103:10834-9. 2006
    ..The strain coverage could be increased to 90% and above by the addition of CpG oligonucleotides or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood...
  6. ncbi Facing the crisis: improving the diagnosis of tuberculosis in the HIV era
    Mark D Perkins
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    J Infect Dis 196:S15-27. 2007
    ..In this article, we will define the need for better TB tests and describe technologies being developed to meet that need...
  7. pmc Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection
    Loic Coutte
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America
    PLoS Pathog 5:e1000293. 2009
    ....
  8. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
    ..These data provide further support for inclusion of this molecule in a meningococcal vaccine. To reflect the critical function of this molecule, we suggest calling it fH-binding protein...
  9. pmc Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
    Naomi Ohnishi
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Health Administration Center, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 105:1003-8. 2008
    ..pylori-associated neoplasms...
  10. ncbi Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
    G Vitale
    Dipartimento di Scienze Biomediche, Universita di Padova, Italy
    Biochem Biophys Res Commun 248:706-11. 1998
    ..The possible implications of these findings for the cytolysis of macrophage cells induced by LF are discussed. These results open the way to the design and screening of specific inhibitors of LF...
  11. pmc Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi
    B Wilske
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Universitat Munchen, Germany
    Infect Immun 61:2182-91. 1993
    ....
  12. pmc Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    Susan L Fink
    Molecular and Cellular Biology Program, Departments of Microbiology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:4312-7. 2008
    ....
  13. pmc Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis
    Kristi M Guinn
    Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 51:359-70. 2004
    ..Our results indicate that RD1 genes work together to form a single virulence determinant, and argue that RD1 encodes a novel specialized secretion system that is required for pathogenesis of MTB...
  14. ncbi c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    Markus Stein
    IRIS Chiron S p A, Via Fiorentina 1, 53100 Siena, Italy
    Mol Microbiol 43:971-80. 2002
    ..Thus, CagA translocation followed by tyrosine phosphorylation at the EPIYA motifs promotes a growth factor-like response with intense cytoskeletal rearrangements, cell elongation effects and increased cellular motility...
  15. pmc Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
    Heather M Scobie
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:5170-4. 2003
    ..These studies distinguish CMG2 as a second anthrax toxin receptor and identify a potent antitoxin that may prove useful for the treatment of anthrax...
  16. pmc Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load
    Kerry A Millington
    Tuberculosis Immunology Group, Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute of Infection and Immunity, Imperial College London, London, United Kingdom
    J Immunol 178:5217-26. 2007
    ..These distinct T cell functional signatures before and after treatment suggest a novel immunological marker of mycobacterial load and clinical status in tuberculosis that now requires validation in larger prospective studies...
  17. ncbi Oncogenic mechanisms of the Helicobacter pylori CagA protein
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Nat Rev Cancer 4:688-94. 2004
    ..Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis...
  18. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
  19. ncbi Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
    ..We assessed the association of new and established cagA and vacA polymorphisms with disease...
  20. ncbi Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    Eric D Boyden
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:240-4. 2006
    ....
  21. pmc Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870
    Vega Masignani
    IRIS, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy
    J Exp Med 197:789-99. 2003
    ..The novel antigen is a top candidate for the development of a new vaccine against meningococcus...
  22. ncbi Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis
    J T Belisle
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Science 276:1420-2. 1997
    ..Furthermore, the use of an antagonist (6-azido-6-deoxy-alpha, alpha'-trehalose) of this activity demonstrates that these proteins are essential and potential targets for new antimycobacterial drugs...
  23. pmc Activation of beta-catenin by carcinogenic Helicobacter pylori
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 102:10646-51. 2005
    ..cag- strains or uninfected persons. These results indicate that H. pylori-induced dysregulation of beta-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen...
  24. pmc Geographic uniformity of the Lyme disease spirochete (Borrelia burgdorferi) and its shared history with tick vector (Ixodes scapularis) in the Northeastern United States
    Wei Gang Qiu
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 160:833-49. 2002
    ..We therefore conclude that the genetic structure of B. burgdorferi has been intimately shaped by the natural history of its main vector, the northern lineage of I. scapularis ticks...
  25. ncbi Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara
    Nilu P Goonetilleke
    Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 171:1602-9. 2003
    ..These findings support further evaluation of mucosally targeted prime-boost vaccination approaches for tuberculosis...
  26. pmc Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway
    A Hubner
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 98:12724-9. 2001
    ..burgdorferi. Our findings provide a foundation for elucidating further key regulatory networks that potentially impact many aspects of B. burgdorferi's parasitic strategy, host range, and virulence expression...
  27. pmc Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Dept of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    J Exp Med 200:1647-55. 2004
    ..We also provide genetic evidence that ALO is required for induction of macrophage apoptosis in response to infection with live B. anthracis and that other CDC family members share the ability to activate TLR4...
  28. ncbi Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells
    Thomas Lindenstrøm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 182:8047-55. 2009
    ....
  29. pmc Receptors of anthrax toxin and cell entry
    Gisou van der Goot
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, SV AI Extension, Station 15, 1015 Lausanne, Switzerland
    Mol Aspects Med 30:406-12. 2009
    ..The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed...
  30. pmc Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice
    Mahtab Moayeri
    National Institutes of Health, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:670-82. 2003
    ..The evidence presented shows that LT kills mice through a TNF-alpha-independent, FasL-independent, noninflammatory mechanism that involves hypoxic tissue injury but does not require macrophage sensitivity to toxin...
  31. ncbi Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
    Sushil Kumar Pathak
    Bose Institute, Department of Chemistry, Kolkata 700 009, India
    Nat Immunol 8:610-8. 2007
    ....
  32. pmc Anthrax lethal toxin induces endothelial barrier dysfunction
    Jason M Warfel
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bldg 29, Rm 129, Bethesda, MD 20892, USA
    Am J Pathol 166:1871-81. 2005
    ..The present findings support a possible role for LT-induced barrier dysfunction in the vascular permeability changes accompanying systemic anthrax infection...
  33. ncbi The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens
    Troy Bankhead
    Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
    Mol Microbiol 65:1547-58. 2007
    ..Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation...
  34. pmc Vaccine potential of the Neisseria meningitidis 2086 lipoprotein
    Leah D Fletcher
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    Infect Immun 72:2088-100. 2004
    ..The rLP2086 family of antigens are candidates worthy of further vaccine development...
  35. ncbi Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells
    Jean Nicolas Tournier
    Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, La Tronche Cedex, France
    J Immunol 174:4934-41. 2005
    ..These results suggest that ET produced during infection impairs DC functions and cooperates with LT to suppress the innate immune response. This may represent a new strategy developed by B. anthracis to escape the host immune response...
  36. pmc Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
    ..The induction of a spirochetal virulence factor preceding the time and host in which it is required demonstrates a developmental sequence for transmission of this arthropod-borne pathogen...
  37. pmc Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing
    Wei Gang Qiu
    Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:14150-5. 2004
    ..Frequent recombination implies a potential for rapid adaptive evolution and a possible polygenic basis of B. burgdorferi pathogenicity...
  38. ncbi Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens?
    Sayera Banu
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 44:9-19. 2002
    ..Subcellular fractionation studies and immunoelectron microscopy localized many PE-PGRS proteins in the cell wall and cell membrane of M. tuberculosis. The data suggest that some PE-PGRS proteins are variable surface antigens...
  39. ncbi Discovery of novel Streptococcus pneumoniae antigens by screening a whole-genome lambda-display library
    Elisa Beghetto
    Kenton Srl, Pomezia, Rome, Italy
    FEMS Microbiol Lett 262:14-21. 2006
    ..For the development of effective vaccines able to prevent pneumococcal infection, characterization of bacterial antigens involved in host immune response is crucial...
  40. ncbi New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:413-22. 2006
    ..The review concludes by highlighting areas where evidence is lacking, and provides an agenda for future research. Active TB and drug resistance are discussed in Part II; 423-432 of this issue...
  41. ncbi Antigenic variation with a twist--the Borrelia story
    Steven J Norris
    Department of Pathology University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225 0708, USA
    Mol Microbiol 60:1319-22. 2006
    ..These two systems thus appear to represent divergence from a common precursor followed by functional convergence to create two distinct antigenic variation processes...
  42. pmc Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37
    K L Seib
    Molecular Genetics Unit, Novartis Vaccines, Via Fiorentina, 1, 53100 Siena, Italy
    Infect Immun 77:292-9. 2009
    ....
  43. ncbi Identification of the cellular receptor for anthrax toxin
    K A Bradley
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, 1400 University Avenue, Madison, Wisconsin 53706, USA
    Nature 414:225-9. 2001
    ..In addition, a soluble version of this domain can protect cells from the action of the toxin...
  44. ncbi Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH
    Y Yamaoka
    VA Medical Center and Baylor College of Medicine, Houston, Texas, USA
    Gastroenterology 117:342-9. 1999
    ..We investigated whether structural subtypes of the cagA 3' region are associated with presentation of the infection or to susceptibility to acid...
  45. ncbi Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis
    Jun Wang
    Department of Pathology and Molecular Medicine and Division of Infectious Diseases, Centre for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Immunol 173:6357-65. 2004
    ..Our study also lends strong evidence that respiratory mucosal vaccination is critically advantageous over systemic routes of vaccination against TB...
  46. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
    ....
  47. pmc Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis
    Abebech Demissie
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 13:179-86. 2006
    ....
  48. ncbi M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
    Heiko Herwald
    Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
    Cell 116:367-79. 2004
    ..In addition, M protein/fibrinogen complexes were identified in tissue biopsies from a patient with necrotizing fasciitis and STSS, further underlining the pathogenic significance of such complexes in severe streptococcal infections...
  49. ncbi Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    H D Brightbill
    Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA
    Science 285:732-6. 1999
    ..Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens...
  50. pmc ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity
    Marien I de Jonge
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    J Bacteriol 189:6028-34. 2007
    ..tuberculosis is the interaction with biomembranes that occurs after dissociation from its putative chaperone CFP-10 under acidic conditions typically encountered in the phagosome...
  51. pmc Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    J Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:670-5. 2001
    ..burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host...
  52. ncbi The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression
    Steven C Derrick
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Cell Microbiol 9:1547-55. 2007
    ..Finally, experimental results using a cell impermeable fluorescent stain suggests that the formation of membrane pores may be a primary mechanism by which ESAT6 evokes an apoptotic response...
  53. pmc Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    PLoS Pathog 3:1240-9. 2007
    ..These findings provide an improved understanding of immunodominance in humans and may contribute to a development of an effective TB vaccine and improved immunodiagnostics...
  54. pmc Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 300:1430-4. 2003
    ..CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions...
  55. pmc Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice
    Virginie Roupie
    Mycobacterial Immunology, WIV Pasteur Institute Brussels, 642 Engelandstraat, B1180 Brussels, Belgium
    Infect Immun 75:941-9. 2007
    ..These findings have implications for proof-of-concept studies in mice mimicking tuberculosis (TB) latency models and their extrapolation to humans for potential new vaccination strategies against TB...
  56. pmc Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6
    Philip S Renshaw
    Department of Biochemistry, University of Leicester, Leicester, UK
    EMBO J 24:2491-8. 2005
    ....
  57. ncbi Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure
    Giovanni Delogu
    Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Mol Microbiol 52:725-33. 2004
    ..Regulated expression of PE genes could have implications for the survival and pathogenesis of mycobacteria within the human host and in other environmental niches...
  58. pmc cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    S Censini
    Immunobiological Research Institute of Siena, Chiron Vaccines, Italy
    Proc Natl Acad Sci U S A 93:14648-53. 1996
    ..Thus, we believe the cag region may encode a novel H. pylori secretion system for the export of virulence determinants...
  59. ncbi Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis
    Ellen Murphy
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    J Infect Dis 200:379-89. 2009
    ..We report an extensive survey and phylogenetic analysis of the diversity of fhbp genes and predicted protein sequences in invasive clinical isolates obtained in the period 2000-2006...
  60. ncbi SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Science 295:683-6. 2002
    ..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...
  61. ncbi Superantigens and their potential role in human disease
    B L Kotzin
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206
    Adv Immunol 54:99-166. 1993
    ..Finally, it is apparent that superantigens have dramatic effects on the immune system. One wonders whether these molecules or modifications of them can be used as specific modulators of the immune system to treat disease...
  62. ncbi Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    Matthias Selbach
    Max Planck Institut für Infektionsbiologie, Abt Molekulare Biologie, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Biol Chem 277:6775-8. 2002
    ....
  63. ncbi Helicobacter pylori in North and South America before Columbus
    Yoshio Yamaoka
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 517:180-4. 2002
    ..pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that H. pylori crossed the Bering Strait from Asia to the New World at different times...
  64. ncbi Role of type IV secretion in Helicobacter pylori pathogenesis
    Steffen Backert
    Otto von Guericke Universitat Magdeburg, Institut fur Medizinische Mikrobiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cell Microbiol 10:1573-81. 2008
    ..The contribution of these signalling cascades to H. pylori pathogenesis is discussed...
  65. pmc Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
    Katherine E Wickliffe
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Microbiol 10:332-43. 2008
    ..Our data indicate that inflammasome formation is a contributing, but not initiating, event in LT-mediated cytotoxicity and that earlier LT-mediated events leading to ion fluxes are required for death...
  66. ncbi Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient
    Bryan A Krantz
    Department of Microbiology and Molecular Genetics, Harvard Medical School 200 Longwood Ave, Boston, MA 02115, USA
    J Mol Biol 355:968-79. 2006
    ..In a sense, the channel functions as a proton/protein symporter...
  67. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    ..iceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, and cagA were helpful in predicting the clinical presentation of an H. pylori infection...
  68. pmc Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis
    G W Anderson
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Infect Immun 64:4580-5. 1996
    ..pestis...
  69. pmc Improved diagnostic evaluation of suspected tuberculosis
    Davinder P S Dosanjh
    Tuberculosis Immunology Group, Imperial College London, London, United Kingdom
    Ann Intern Med 148:325-36. 2008
    ..The role of new T-cell-based blood tests for tuberculosis in the diagnosis of active tuberculosis is unclear...
  70. ncbi Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Immunol 177:6353-60. 2006
    ..tb in LTK63/Ag85B-ESAT-6-boosted mice, compared with BCG-vaccinated animals. Thus, LTK63/Ag85B-ESAT-6 represents an efficient preventive vaccine against tuberculosis with a strong ability to boost prior BCG immunity...
  71. pmc Identification and molecular characterisation of a fibrinogen binding protein from Streptococcus iniae
    Justice C F Baiano
    Aquatic Animal Health Laboratory, Centre for Marine Studies, The University of Queensland, St Lucia, 4072, Australia
    BMC Microbiol 8:67. 2008
    ..iniae, a Lancefield non-typeable pathogen causing devastating fish losses in the aquaculture industry and an opportunistic pathogen of humans, and identifies the proteins involved and their encoding genes...
  72. ncbi Crystal structure of the anthrax lethal factor
    A D Pannifer
    Biochemistry Department, University of Leicester, Leicester LE1 7RH, UK
    Nature 414:229-33. 2001
    ..The structure thus reveals a protein that has evolved through a process of gene duplication, mutation and fusion, into an enzyme with high and unusual specificity...
  73. ncbi Prevalence of Helicobacter pylori pathogenicity-associated cagA and vacA genotypes among Pakistani dyspeptic patients
    Tanvir Ahmad
    Life Sciences Group, IAD, PINSTECH, Nilore, Islamabad, Pakistan
    FEMS Immunol Med Microbiol 55:34-8. 2009
    ..5%) followed by s1a/m1 (19.7%). cagA was positive in 24.2% of the cases and strongly associated with s1a/m1, vacA. The prevalence of virulent cagA, and vacA allelic form s1a/m1 was lower than that reported from neighboring countries...
  74. pmc OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 113:220-30. 2004
    ..These studies conclusively demonstrate the importance of OspC in the invasion of tick salivary glands by B. burgdorferi, a critical step in the transmission of spirochetes from the arthropod vector to the mammalian host...
  75. pmc A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection
    Sandra G Morrison
    Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 175:7536-42. 2005
    ..These results impact our understanding of immunity to chlamydial genital infection and may provide important insight into vaccine development...
  76. pmc Rapid clearance of Lyme disease spirochetes lacking OspC from skin
    Kit Tilly
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 75:1517-9. 2007
    ..To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission...
  77. ncbi Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility
    M Poppe
    Junior Research Group, Paul Ehrlich Institute, Langen, Germany
    Oncogene 26:3462-72. 2007
    ..pylori infection and pathogenicity. These results implicate c-Abl as a novel molecular target for therapeutic intervention in H. pylori-related gastric diseases...
  78. ncbi Alteration of epitope recognition pattern in Ag85B and ESAT-6 has a profound influence on vaccine-induced protection against Mycobacterium tuberculosis
    Thomas Bennekov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Eur J Immunol 36:3346-55. 2006
    ....
  79. ncbi Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway
    Fredric Carlsson
    Department of Medical Microbiology, Dermatology and Infection, Lund University, Solvegatan 23, SE 22362 Lund, Sweden
    Mol Microbiol 56:28-39. 2005
    ..Our data identify a novel function for surface-bound Fg and allow us to propose a unifying mechanism by which M proteins interfere with innate immunity...
  80. ncbi Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice
    Motohiro Miura
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Int J Cancer 125:2497-504. 2009
    ..Differential oncogenic potential of geographically distinct CagA isoforms may contribute to the differential prevalence of gastric carcinoma between East Asian countries and Western countries...
  81. ncbi Helicobacter pylori and gastric carcinogenesis
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 0815, Japan
    J Gastroenterol 44:239-48. 2009
    ..Ectopically expressed AID may contribute to H. pylori-initiated gastric carcinogenesis by increasing the risk of likelihood of epithelial cells acquiring mutations in cancer-related genes...
  82. pmc Frequent homologous recombination events in Mycobacterium tuberculosis PE/PPE multigene families: potential role in antigenic variability
    Anis Karboul
    Unit of Typing and Genetics of Mycobacteria, Institut Pasteur de Tunis, Tunis, Tunisia
    J Bacteriol 190:7838-46. 2008
    ..The finding of high prevalence (approximately 45% and approximately 58%) for at least two of the genomic deletions suggests that they likely confer advantageous biological attributes...
  83. pmc Review of meningococcal group B vaccines
    Dan M Granoff
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Clin Infect Dis 50:S54-65. 2010
    ..Thus, the prospects have never been better for developing vaccines for prevention of meningococcal disease, including that caused by group B strains...
  84. pmc The protective antigen component of anthrax toxin forms functional octameric complexes
    Alexander F Kintzer
    Department of Chemistry, University of California, Berkeley, 94720, USA
    J Mol Biol 392:614-29. 2009
    ..This assembly mechanism may provide a novel means to control cytotoxicity...
  85. pmc Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:105-15. 2008
    ....
  86. pmc Protective antigen as a correlative marker for anthrax in animal models
    David Kobiler
    Department of Infectious Diseases, Israel Institute for Biological Research, P O Box 19, Ness Ziona, Israel 74100
    Infect Immun 74:5871-6. 2006
    ..As the time required for immunodetection of PA can be very short, the use of this marker will be beneficial for faster diagnosis and treatment of inhalation anthrax...
  87. ncbi A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system
    Manfred Rohde
    Max von Pettenkofer Institut für Hygiene and Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, D 80336 MUnchen, Germany
    Mol Microbiol 49:219-34. 2003
    ..These observations demonstrate for the first time by microscopic techniques a complex T4SS-associated, sheathed surface organelle reminiscent to the needle structures of bacterial type III secretion systems...
  88. pmc Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations
    Natalie E R Beveridge
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur J Immunol 37:3089-100. 2007
    ..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses...
  89. ncbi Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, England
    Gastroenterology 127:514-23. 2004
    ....
  90. pmc Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates
    Muriel C Schneider
    Centre for Molecular Microbiology and Infection, Imperial College, London SW7 2AZ, UK
    Nature 458:890-3. 2009
    ..The structure also indicates the molecular basis of the host-specificity of the interaction between fH and the meningococcus, and informs attempts to develop novel therapeutics and vaccines...
  91. ncbi Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents
    Chris Druar
    Cangene Corporation, Mississauga, ON, Canada
    FEMS Immunol Med Microbiol 52:78-87. 2008
    ..However, these ELISAs had low diagnostic accuracy in endemic regions, possibly due to previous patient exposure to B. pseudomallei...
  92. ncbi Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  93. ncbi Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing
    Raynal C Squires
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 282:34260-7. 2007
    ..Taken together, caspase-1-mediated necrosis appears to be tightly controlled and differentially regulated by proteasomes depending on the source of caspase-1 induction...
  94. pmc CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
    Gabrielle T Belz
    Division of Immunology and Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 175:196-200. 2005
    ..We show that regardless of the type of intracellular infection, CD8alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity...
  95. ncbi Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8
    W Fischer
    , , Pettenkoferstr. 9a, , Germany
    Mol Microbiol 42:1337-48. 2001
    ..We identified a point mutation in gene hp0532, causing a premature translational stop in the corresponding polypeptide chain, providing a putative explanation for the defect in the type IV secretion system of the spontaneous mutant...
  96. ncbi Anthrax toxin: receptor binding, internalization, pore formation, and translocation
    John A T Young
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Annu Rev Biochem 76:243-65. 2007
    ....
  97. pmc Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling
    Silvia Rossi Paccani
    Department of Evolutionary Biology, Policlinico Le Scotte, University of Siena, 53100 Siena, Italy
    J Exp Med 201:325-31. 2005
    ..These data identify a novel strategy of immune evasion by B. anthracis, based on both effector subunits of the toxic complex, and targeted to a key cellular component of adaptive immunity...
  98. pmc Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon
    Katarina Radosevic
    Crucell Holland BV, Archimedesweg 4 6, 2333 CN Leiden, The Netherlands
    Infect Immun 75:4105-15. 2007
    ..These results unify conflicting reports on the relative importance of CD4 versus CD8 T-cell responses in protection and emphasize the key role of IFN-gamma...
  99. ncbi The alveolar macrophage: the Trojan horse of Bacillus anthracis
    Chantal Guidi-Rontani
    Laboratoire Organismes Photosynthetiques et Environnement, Ecole Normale Superieure, 46 rue d Ulm, 75005 CNRS URA2172, Paris, France
    Trends Microbiol 10:405-9. 2002
    ..Here, recent advances in the analysis of B. anthracis pathogenesis are summarized and future challenges discussed...
  100. pmc Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens
    Robin Ireland
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000921. 2010
    ..Lastly, CLDC+MPF was also effective at controlling infections with Yersinia pestis, Burkholderia pseudomallei and Brucella abortus. Thus, CLDC+MPF represents a novel prophylaxis to protect against multiple, highly virulent pathogens...
  101. ncbi Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats
    Xizhong Cui
    Critical Care Medicine Department, National Institutes of Health, Bldg 10, Rm 7D43, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 286:R699-709. 2004
    ..Although therapies to modulate these host mediators may be applicable fo shock caused by LPS or other bacterial toxins, they may not with LeTx...

Research Grants63

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ..include defective immunoregulation, mucosal barrier integrity/repair and bacterial killing, while enteric bacterial antigens stimulate intestinal inflammation...
  3. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..regulates phagosome maturation steps in DCs that are required for optimal presentation of phagocytosed bacterial antigens by MHC-II. We will test this hypothesis in the following Specific Aims: 1...
  4. Cytoskeletal Keratins in Epithelial Immunity to Bacterial Keratitis
    K P CONNIE TAM; Fiscal Year: 2013
    ..Phosphatase inhibitors, kinase activators and bacterial antigens will be used to promote keratin solubilization...
  5. Regulation of Intestinal Epithelial Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Narrative Defective intestinal barrier or "leaky gut" allows bacterial antigens in the gut to be absorbed and induce inflammatory response...
  6. Regulation of the Poly Sialic Virulence Factor
    ERIC ROSS VIMR; Fiscal Year: 2013
    ..We hypothesize that understanding the in vivo functions of these bacterial antigens will facilitate approaches targeting them for new therapeutic development...
  7. Apoptosis and efferocytosis: regulators of immunity to tuberculosis
    Samuel M Behar; Fiscal Year: 2013
    ..Apoptosis also links innate and clonal immunity. DC present bacterial antigens packaged in apoptotic vesicles to T cells, leading to better T cell priming and protection in vivo...
  8. Dialysis Infection and Vitamin D in New England: The DIVINE Study
    Ravi Thadhani; Fiscal Year: 2012
    ..macrophage gene expression profiles and whole blood cytokine profiles following ex-vivo stimulation with bacterial antigens (e.g., killed S. aureus)...
  9. The role of CBir1 flagellin-specific Th17 and Th1 effector cells in colitis
    Yingzi Cong; Fiscal Year: 2012
    ..This project will explore how different subsets of lamina propria DC respond to recently defined dominant bacterial antigens of Crohn's disease, and how they instruct pathogenic effector T cell development in the intestine...
  10. Regulation of the Poly Sialic Virulence Factor
    Eric Vimr; Fiscal Year: 2009
    ..We hypothesize that understanding the in vivo functions of these bacterial antigens will facilitate approaches targeting them for new therapeutic development...
  11. Immunomodulatory effects of intestinal helminthes on mucosal immunity
    Hai Ning Shi; Fiscal Year: 2013
    ..will provide new insight into the mechanism by which helminths modulate intestinal responses to luminal bacterial antigens, and facilitate the development of novel, safer and more effective treatments for immune-mediated diseases.
  12. Study of LY108 innate and adaptive immune responses
    CORNELIS P TERHORST; Fiscal Year: 2013
    ..and mechanistic networks that are implicated in the regulation of innate and adaptive immune responses to bacterial antigens and/or mouse antigens induced by colonic bacteria...
  13. Initiation and maintenance of adaptive immunity to Mycobacterium tuberculosis
    TYLER DALLAS BOLD; Fiscal Year: 2010
    ..Therefore, the availability of bacterial antigens and the functional properties of host antigen presenting cells at both of these sites critically determine ..
  14. Regulation of B cell Clonal Diversity and Its Role in Disease
    JOHN FRANKLIN KEARNEY; Fiscal Year: 2013
    ..Preliminary data shows that neonatal exposure to defined conserved bacterial antigens shared by a variety of allergen bearing organisms induce dramatic and permanent changes in the resulting B ..
  15. The Role of the Maternal and Developmental Environments in Adult Phenotype
    JENNIFER GRINDSTAFF; Fiscal Year: 2010
    ..The proposed research will test these hypotheses simultaneously by experimentally manipulating exposure to bacterial antigens and stress hormones in females, developing young, and adults...
  16. Regulation of Mucosal Immunity by Pro- and Anti-inflammatory Salivary Defensins
    Michael E Selsted; Fiscal Year: 2013
    ..of salivary defensins on the infectivity of HIV of oral epithelial cells, the response of oral epithelium to bacterial antigens, and the transport of HIV from the epithelial cells to permissive CD4+ target cells...
  17. Novel intracellular pattern recognition receptor expression by resident CNS cells
    Ian Marriott; Fiscal Year: 2009
    ..we showed that NOD2 is an important component in the in vitro inflammatory responses of resident glia to bacterial antigens. Finally, we established that NOD2 is required, at least in part, for the astrogliosis, demyelination, ..
  18. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..coli strains have been proposed. In addition, autoantibodies derived from molecular mimicry from bacterial antigens, or from host origin may also be causative agents of the inflammatory lesions in CD...
  19. A unique mouse model for studying immunity to virulent Franciscella infections
    Gary R Klimpel; Fiscal Year: 2010
    ..protective for mice following aerosol challenge with virulent Francisella tularensis (SCHU S4) and that the bacterial antigens recognized by protective antibodies can be used as an effective vaccine...
  20. Visualizing the innate and adaptive immune response to Listeria monocytogenes
    KAMAL MOHAN KHANNA; Fiscal Year: 2013
    ..2) To determine the anatomical mechanisms surrounding ineffectual vaccination. 3) To Determine the cellular mechanisms for the splenic trafficking of live-LM and bacterial antigens in vivo.
  21. IBD: Genetic and Immunopathologic Mechanisms
    Stephan R Targan; Fiscal Year: 2013
    ..We hypothesize that patients who lack antibody responses to bacterial antigens and who have mild, non-progressive disease, are likely to 'carry'genetic variants associated with ..
  22. ISEV Meeting (International Society of Extracellular Vesicles)
    Fred H Hochberg; Fiscal Year: 2013
    ..the clinical roles of microvesicles (MCV), exosomes (EXO), transcriptomes in presentation of viral and bacterial antigens, interactions of cell-cell mRNA, as well as mcRNA and protein interactions and presentation of immune-..
  23. IDENTIFY ANTIGENIC DETERMINANTS OF HUMAN PERIODONTITIS
    YEN TUNG TENG; Fiscal Year: 2001
    ..The long-term objective of this research program is to identify bacterial antigens important for immune and inflammatory responses in human periodontitis...
  24. CHLAMYDIA TRACHOMATIS ENVELOPE COMPONENTS AND VIRULENCE
    JANE RAULSTON; Fiscal Year: 2003
    ..The availability of iron is well-known to have a tremendous influence on the production of bacterial antigens, envelope components and virulence factors; these effects are particularly prominent for obligate ..
  25. STRUCTURE OF THE RECEPTORS FOR ORAL BACTERIAL ADHESINS
    C Bush; Fiscal Year: 1991
    ..the course of the structural studies will be available for use as probes of the immunological reactivity of bacterial antigens and as probes of the lectin receptor sites...
  26. PERIODONTAL DISEASES: B CELLS ACTIVATED BY MITOGENS
    JAMES CLAGETT; Fiscal Year: 1980
    ..Although there is evidence that specific immunity to bacterial antigens may be important, recent data from our laboratory suggest that nonspecific polyclonal activation of host B-..
  27. Soluble Decoy Receptor 3 in Bacterial Infection and Sepsis
    Sunghee Kim; Fiscal Year: 2006
    ..DcR3 in the tumor necrosis factor receptor family is selectively increased in human cells in response to bacterial antigens, and that the level of DcR3 in sera of patients with suspected bacterial infections is significantly higher ..
  28. CD4+ T CELLS RESPONDING TO SALMONELLA INFECTION
    Brad Cookson; Fiscal Year: 2005
    ..However, the specific bacterial antigens (Ags) recognized by Salmonella-immune hosts are largely unknown...
  29. RESISTANCE OF OPPORTUNISTIC INFECTION BY MYCOBACTERIA
    D Blanchard; Fiscal Year: 1992
    ..Monoclonal antibodies to MAI antigens will be raised and added to cytolytic assays to determine whether bacterial antigens on the surface of infected monocytes serve as target structures for LAK cells...
  30. NORMAL AND DISORDERED THYROID HORMONE ECONOMY
    Jorge Silva; Fiscal Year: 1990
    ..unique antigens, including bacter-extracts, that contain TSH receptors; to explore the relationship of other bacterial antigens to the pathogenesis of other thyroid diseases, to elucidate the effects of various lymphokines on the ..
  31. STUDY OF HOST-MICROBIAL FACTORS IN BACILLEMIA
    LOWELL YOUNG; Fiscal Year: 1980
    ..coli. Such tools will be used to attempt detection of circulating bacterial antigens at the onset of bacteremia by screening plasmas obtained simultaneously with culture positive blood...
  32. Psoralen-Killed, Metabolically-Active Anthrax Vaccine
    Thomas Dubensky; Fiscal Year: 2006
    ..e. mucosal, humoral, and cellular immunity), breadth (immune response targeted at multiple bacterial antigens including capsule), and durability (long-term immunological memory) with a practical immunization regimen, ..
  33. EFFECT OF ANTAGONISM AND S-IGA INDIGENOUS ANAEROBES
    RODNEY BERG; Fiscal Year: 1980
    ..in the presence of particular indigenous bacteria may be immunologically tolerant to vaccination with these bacterial antigens compared with the immune responses of germfree mice raised in the absence of these bacteria but vaccinated ..
  34. HUMAN HYBRIDOMAS IN THE ANALYSIS OF AUTOIMMUNE DISEASE
    BERNARD STOLLAR; Fiscal Year: 1990
    ..the corresponding antigens will be identified and mutual cross-reactions among nuclear, cell surface and bacterial antigens will be tested...
  35. Bacterial flora in normal esophagus & reflux disorders
    Zhiheng Pei; Fiscal Year: 2005
    ..Each disease group will be compared for the species identified and their prevalence. Cultivable whole cell bacterial antigens will be used in ELISA to determine whether the hosts recognize their presence...
  36. ROLE OF HLA-B27 AND SHIGELLA ANTIGENS IN DISEASE
    John Shively; Fiscal Year: 1980
    ..The second goal has been to purify bacterial antigens from Shigella flexneri and Sh...
  37. SUPPRESSION OF B-LYMPHOMAS VIA INDUCTION OF INTERFERONS
    Andrei Thomas Tikhonenko; Fiscal Year: 2003
    ..This anticipated result will establish that STAg or similar protozoan or bacterial antigens could be developed into new therapeutic modalities for AIDS-related Burkitt lymphoma.
  38. CELLULAR IMMUNE RESPONSES TO ORAL BACTERIAL ANTIGENS
    PRISCILLA CHEN; Fiscal Year: 1980
    ..viscosus fractions will be compared to a soluble sonicate of A. viscosus. Mouse spleen cells will also be tested for production of specific antibody to A. viscosus soluble sonicate, fractions and cell walls. ..
  39. Triggering intestinal inflammation
    Hai Shi; Fiscal Year: 2005
    ..agents to alter intestinal permeability and barrier function, enhancing mucosal immune response to luminal bacterial antigens and causing intestinal inflammation...
  40. Identifying Periodontal Antigens By Protein Microarray
    Douglas Darling; Fiscal Year: 2006
    ..Extensive effort has identified the genes for relatively few bacterial antigens related to periodontitis...
  41. Novel Vaccine Strategy for Listeria monocytogenes
    DARREN HIGGINS; Fiscal Year: 2007
    ..monocytogenes vaccine vectors to deliver protective native bacterial antigens to the cytosol of professional and nonprofessional antigen presenting cells (APC) for endogenous processing ..
  42. REGULATION OF B CELL CLONAL DIVERSITY
    John Kearney; Fiscal Year: 2000
    ..The hypothesis will be tested that this B-cell subset expresses BCR's that bind common bacterial antigens and can mount a rapid, protective T-cell- independent antibody response to blood borne organisms...
  43. GUT FLORA AS A PROVOCATEUR OF AUTOIMMUNE COLITIS
    Peter Felsburg; Fiscal Year: 2002
    ..The IL-2/- mouse, however, seems to offer a promising model to probe the possible relationships between gut bacterial antigens and specific T cells that may initiate inflammatory bowl lesions...
  44. BACTERIAL ADHERENCE IN URINARY TRACT INFECTIONS
    DAVID UEHLING; Fiscal Year: 1980
    ..Following UTI, urinary secretory IgA also increases. Experimental animals immunized by placing bacterial antigens into the bladder subsequently demonstrate decreased bacterial adherence...
  45. Cannabinoid-induced apoptosis in T cell regulation
    Prakash Nagarkatti; Fiscal Year: 2007
    ..2, we will test the hypothesis that THC-induced apoptosis is responsible for decreased T cell response to bacterial antigens by using the superantigen model and analyzing antigen-specific Vbeta3+ and Vbetal 1+ T cells...
  46. IMMUNE RESPONSES TO YERSINIA IN THYROID DISEASE
    Louis Shenkman; Fiscal Year: 1980
    ..between Yersinia and thyroid disease, increase our understanding of cross-reactions between mammalian and bacterial antigens, and provide insights into possible immunologic mechanisms responsible for certain forms of thyroid disease.
  47. H. INFLUENZAE HMW ADHESION PROTEINS IN HOST IMMUNITY
    Stephen Barenkamp; Fiscal Year: 2002
    ..The long-term objectives of this project are to identify those surface-exposed bacterial antigens of NTHI that are important in a protective host immune response and ultimately to address the question of ..
  48. Differential Roles of TLR2 and TLR4 in Adaptive Immunity
    Matthew Fenton; Fiscal Year: 2004
    ..are crucial to the initiation of adaptive immune responses because of their ability to process and present bacterial antigens to na'fve T cells...
  49. CHRONIC INTESTINAL INFLAMMATION--MECHANISMS AND EFFECTS
    CHARLES ELSON; Fiscal Year: 2003
    ..the induction and regulation of the mucosal immune system, especially mucosal responses to enteric bacterial antigens,...
  50. Different bacterial species selectively induce TH1 cells
    Sandra Kim; Fiscal Year: 2009
    ..phenotypes in genetically susceptible hosts due to either regionally restricted mucosal immune responses to bacterial antigens or b...
  51. T Cell Expansion and Colitis in Immunodeficient Mice
    Charles Surh; Fiscal Year: 2009
    ..In this system, host ARC loaded with commensal bacterial antigens are believed to induce the donor CD4 cells to undergo strong activation and differentiation into effector T ..
  52. REAGINIC ANTIBODY FORMATION TO BACTERIAL ANTIGENS
    Gabriel Michael; Fiscal Year: 1980
    ..Several strains of E. coli, P. aeruginosa, S. typhosa and other gramnegative bacteria are being tested. Bacterial antigens responsible for induction of reaginic antibodies are being isolated and characterized...
  53. ANTIBIOTIC OF CHRONIC LYME DISEASE IN MONKEYS
    MARIO PHILIPP; Fiscal Year: 1999
    ..will include: culture and PCR of skin biopsies; PCR and RT-PCR applied to CSF; immunological detection of bacterial antigens in urine, and qualitated and quantitated analysis of anti-borrelial antibodies paired sera and CSF, anti p39 ..
  54. ANTIGEN DELIVERY SYSTEM DESIGN FOR HOST DEFENSE ANALYSIS
    Roy Curtiss; Fiscal Year: 2004
    ..The investigators will use heterologous bacterial antigens, and evaluate strains constructed in mice to assess mucosal, humoral and cellular immunity after oral ..
  55. MOLECULAR ANALYSIS T(11--18)(Q21--Q21)--MALT LYMPHOMA
    Jeffrey Sklar; Fiscal Year: 2001
    ..mucosal sites during early stages of dissemination, proliferation in respon to or dependent upon specific bacterial antigens, and regression or elimination by antibiotic treatment of the bacterial source of the stimulat y antigen...
  56. A novel therapy for sepsis
    Sunghee Kim; Fiscal Year: 2007
    ..Moreover, the level of DcR3 was significantly elevated in human cells in response to bacterial antigens and in sera of patients with bacterial infections thus indicating that the protein might play an important ..
  57. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  58. Etiology & pathogenesis of chronic tonsillar hypertrophy
    Zhiheng Pei; Fiscal Year: 2009
    ..The hypothesis to be tested is that CTH is caused by bacterial antigens from metacolonies. This hypothesis is based on our preliminary data: i...
  59. A therapeutic potential of soluble decoy receptor 3 in sepsis
    Sunghee Kim; Fiscal Year: 2006
    ..Moreover, the level of this protein was significantly elevated in human cells in response to bacterial antigens and in sera of patients with bacterial infections thus indicating that the protein might play an important ..
  60. IMMUNOREGULATION BY ANTI-IDIOTOPES
    Jan Cerny; Fiscal Year: 1992
    ..These Id- specific T cells (TId) are perceived as the major regulators of antibody response to bacterial antigens and, perhaps, as immunosurveillance cells for the Id-positive lymphomas...
  61. Events Leading to Loss Of Tolerance to Myelin Basic Pro*
    Joan Goverman; Fiscal Year: 2003
    ..We also show that the MBP-specific TCR does not appear to cross-react with bacterial antigens. Additional preliminary data demonstrate that endogenous MBP is normally processed and presented by ..
  62. Point Detection of Pathogens in Oral Samples via UPT
    Daniel Malamud; Fiscal Year: 2005
    ..multiple infectious diseases The technology platform will permit the simultaneous analyses of viral and/or bacterial antigens and nucleic acids, as well as antibodies to these pathogens...
  63. MATRIX-ASSISTED LASER DESORPTION MASS SPECTROMETER
    GEORGE KENYON; Fiscal Year: 1993
    ..receptors, fundamental studies of receptor mediated uptake of circulating proteins and glycoproteins, and bacterial antigens. The internal Advisory Committee will be responsible for the overall guidance of the instrument's shared use ..