autoantigens

Summary

Summary: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

Top Publications

  1. pmc The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 200:45-60. 2013
  2. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  3. pmc Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP
    Daniel R Foltz
    Ludwig Institute for Cancer Research, La Jolla, CA 92093 0670, USA
    Cell 137:472-84. 2009
  4. ncbi Crystal structure of the human centromeric nucleosome containing CENP-A
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Nature 476:232-5. 2011
  5. ncbi Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
  6. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
  7. pmc HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
    Meghan C Barnhart
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Cell Biol 194:229-43. 2011
  8. ncbi HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres
    Elaine M Dunleavy
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR CNRS Institut Curie, Paris, France
    Cell 137:485-97. 2009
  9. ncbi CIP2A inhibits PP2A in human malignancies
    Melissa R Junttila
    Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland
    Cell 130:51-62. 2007
  10. pmc In vitro centromere and kinetochore assembly on defined chromatin templates
    Annika Guse
    Department of Biochemistry, Stanford Medical School, Beckman 409A, Stanford, California 94305 5307, USA
    Nature 477:354-8. 2011

Detail Information

Publications338 found, 100 shown here

  1. pmc The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 200:45-60. 2013
    ..Based on the analysis of these different engineered kinetochores, we conclude that the CCAN has two distinct roles: recruiting CENP-A to establish the kinetochore and serving as a structural core to directly recruit kinetochore proteins...
  2. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  3. pmc Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP
    Daniel R Foltz
    Ludwig Institute for Cancer Research, La Jolla, CA 92093 0670, USA
    Cell 137:472-84. 2009
    ..We propose HJURP to be a cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin assembly...
  4. ncbi Crystal structure of the human centromeric nucleosome containing CENP-A
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Nature 476:232-5. 2011
    ..The structure provides the first atomic-resolution picture of the centromere-specific nucleosome...
  5. ncbi Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
    ..We investigated the onset and progression of autoantibody development before the clinical diagnosis...
  6. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
  7. pmc HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
    Meghan C Barnhart
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Cell Biol 194:229-43. 2011
    ....
  8. ncbi HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres
    Elaine M Dunleavy
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR CNRS Institut Curie, Paris, France
    Cell 137:485-97. 2009
    ..We conclude that HJURP is a key factor for CENP-A deposition and maintenance at centromeres...
  9. ncbi CIP2A inhibits PP2A in human malignancies
    Melissa R Junttila
    Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland
    Cell 130:51-62. 2007
    ..Thus, our data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-Myc in human malignancies...
  10. pmc In vitro centromere and kinetochore assembly on defined chromatin templates
    Annika Guse
    Department of Biochemistry, Stanford Medical School, Beckman 409A, Stanford, California 94305 5307, USA
    Nature 477:354-8. 2011
    ..Our unique cell-free system enables complete control and manipulation of the chromatin substrate and thus presents a powerful tool to study centromere and kinetochore assembly...
  11. pmc Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
    I Ching Wang
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 60607 7170, USA
    Mol Cell Biol 25:10875-94. 2005
    ..Taken together, these results demonstrate that FoxM1 regulates transcription of cell cycle genes critical for progression into S-phase and mitosis...
  12. pmc Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes
    Karen E Gascoigne
    Whitehead Institute for Biomedical Research, Department of Biology, Nine Cambridge Center, MA 02142, USA
    Cell 145:410-22. 2011
    ..We additionally find that CENP-T phosphorylation regulates the mitotic assembly of both endogenous and ectopic kinetochores. Thus, CENP-C and CENP-T form a critical regulated platform for vertebrate kinetochore assembly...
  13. pmc Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo
    Minh Bui
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cell 150:317-26. 2012
    ..Our results reveal a cyclical nature to CENP-A nucleosome structure and have implications for the maintenance of epigenetic memory after centromere replication...
  14. pmc Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
    Sophie E Polo
    Department of Biochemistry, The Gurdon Institute, University of Cambridge, Cambridge, UK
    EMBO J 29:3130-9. 2010
    ..These results provide new insights into how the chromatin remodelling complex NuRD contributes to maintaining genome stability...
  15. pmc Assembly of centrosomal proteins and microtubule organization depends on PCM-1
    Alexander Dammermann
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 159:255-66. 2002
    ....
  16. pmc Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore
    Jan H Bergmann
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, UK
    EMBO J 30:328-40. 2011
    ..Our data provide a functional link between the centromeric chromatin, α-satellite transcription, maintenance of CENP-A levels and kinetochore stability...
  17. pmc H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G₁ phase
    Elaine M Dunleavy
    Department of Genome Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Nucleus 2:146-57. 2011
    ..1) at centromeres in G(1) phase compared to S phase. These observations are consistent with a replacement model, where both H3.1 and H3.3 are deposited at centromeres in S phase and 'placeholder' H3.3 is replaced with CENP-A in G(1)...
  18. pmc Characterization of a cis-Golgi matrix protein, GM130
    N Nakamura
    Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK
    J Cell Biol 131:1715-26. 1995
    ..Together these results suggest that GM130 is part of a cis-Golgi matrix and has a role in maintaining cis-Golgi structure...
  19. ncbi Cdk activity couples epigenetic centromere inheritance to cell cycle progression
    Mariana C C Silva
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Dev Cell 22:52-63. 2012
    ..Alleviation of this inhibition in G1 phase ensures tight coupling between DNA replication, cell division, and subsequent centromere maturation...
  20. pmc The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres
    Nikolina Sekulic
    Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6059, USA
    Nature 467:347-51. 2010
    ..Our results indicate that CENP-A marks centromere location by restructuring the nucleosome from within its folded histone core...
  21. pmc CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly
    Ben Moree
    Department of Biochemistry, Stanford University Medical School, Stanford, CA 94305, USA
    J Cell Biol 194:855-71. 2011
    ..We find that M18BP1 directly binds CENP-C through conserved domains in the CENP-C protein. Thus, CENP-C provides a link between existing CENP-A chromatin and the proteins required for new CENP-A nucleosome assembly...
  22. pmc Epigenetic centromere propagation and the nature of CENP-a nucleosomes
    Ben E Black
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cell 144:471-9. 2011
    ..This model reconciles divergent data for CENP-A-containing nucleosomes and provides a basis for how centromere identity is stably inherited...
  23. ncbi NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
    Y Xue
    Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
    Mol Cell 2:851-61. 1998
    ..These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin...
  24. pmc Dual recognition of CENP-A nucleosomes is required for centromere assembly
    Christopher W Carroll
    Department of Biochemistry, Stanford University School of Medicine, Palo Alto, CA 94503, USA
    J Cell Biol 189:1143-55. 2010
    ..We propose that CENP-C binds directly to CENP-A chromatin and, together with CENP-N, provides the foundation upon which other centromere and kinetochore proteins are assembled...
  25. ncbi Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
    J K Tong
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 395:917-21. 1998
    ..Our results establish a physical and functional link between the distinct chromatin-modifying activities of histone deacetylases and nucleosome remodelling proteins...
  26. pmc Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly
    Jun Ichirou Ohzeki
    Department of Human Genome Research, Laboratory of Cell Engineering, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    EMBO J 31:2391-402. 2012
    ..CENP-A arrays assembled de novo by this mechanism can form human artificial chromosomes (HACs) that are propagated indefinitely in human cells...
  27. pmc Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    Jonathan A Deane
    Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
    Immunity 27:801-10. 2007
    ..These results underscore the importance of tightly regulating expression of TLR7 to prevent spontaneous triggering of harmful autoreactive and inflammatory responses...
  28. pmc Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections
    Nina Tavalai
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany
    J Virol 80:8006-18. 2006
    ..These results strongly suggest that PML functions as part of an intrinsic immune mechanism against cytomegalovirus infections...
  29. pmc Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression
    Young Eui Kim
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 300 Cheoncheondong Jangangu, Suwon, Gyeonggido 440 746, Republic of Korea
    J Virol 85:11928-37. 2011
    ..These findings indicate that the IE1-dependent loss of Sp100 proteins during HCMV infection may represent an important requirement for efficient viral growth...
  30. pmc Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini
    Tanya Panchenko
    Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:16588-93. 2011
    ..These findings have implications for understanding CENP-A-containing nucleosome structure and higher-order chromatin folding at the centromere...
  31. ncbi Octameric CENP-A nucleosomes are present at human centromeres throughout the cell cycle
    Abbas Padeganeh
    Institute for Research in Immunology and Cancer IRIC, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    Curr Biol 23:764-9. 2013
    ..Thus, our findings indicate that octameric CENP-A nucleosomes mark the centromeric region to ensure proper epigenetic inheritance and kinetochore assembly...
  32. pmc Autoimmunity and oxidatively modified autoantigens
    Biji T Kurien
    Arthritis and Immunology Program, USA
    Autoimmun Rev 7:567-73. 2008
    ..The fragmentation of scleroderma specific autoantigens occurs as a result of oxidative modification and is thought to be responsible for the production of ..
  33. pmc The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
    Aleksandra A Watson
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    J Mol Biol 422:3-17. 2012
    ....
  34. pmc CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1
    Masahiro Okada
    Center for Priority Areas, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan Department of Chemistry, Graduate School of Sciences and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan Innovative Drug Research Laboratories, Kyowa Hakko Kirin Co, Ltd, Takasaki, Gumma, 370 1295, Japan
    Mol Biol Cell 20:3986-95. 2009
    ..These findings indicate that the CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1...
  35. ncbi Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation
    M W Briggs
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14618, USA
    J Biol Chem 273:13255-63. 1998
    ..These findings indicate that Rrp6p plays a role in 5.8 S rRNA 3' end formation, and they identify a functional intermediate in the rRNA processing pathway...
  36. pmc Dynamics of inner kinetochore assembly and maintenance in living cells
    Peter Hemmerich
    Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany i leibniz de
    J Cell Biol 180:1101-14. 2008
    ..Our data reveal a wide range of cell cycle-specific assembly plasticity of the centromere that provides both stability through sustained binding of some components and flexibility through dynamic exchange of other components...
  37. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
    ..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth...
  38. ncbi Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    Katharina Aschenbrenner
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Nat Immunol 8:351-8. 2007
    ..Thus, 'routing' of mTEC-derived self antigens may determine whether specific thymocytes are deleted or enter the regulatory T cell lineage...
  39. pmc La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:6861-70. 2004
    ..These results provide strong evidence for a function of the La autoantigen in IRES-dependent translation and define the step of translation which is stimulated by La...
  40. pmc Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications
    Catherine A Musselman
    Department of Pharmacology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Biochem J 423:179-87. 2009
    ..Together our findings suggest that the PHD2 finger plays a role in targeting of the CHD4/NuRD complex to chromatin...
  41. pmc Tetrameric organization of vertebrate centromeric nucleosomes
    Emilios K Dimitriadis
    Scanning Probe Microscopy Unit, Biomedical Engineering and Physical Science Shared Resource, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:20317-22. 2010
    ..We discuss implications of our observations in the context of universal epigenetic and mechanical requirements for functional centromeres...
  42. pmc Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function
    Jan H Bergmann
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Building, Mayfield Road, Edinburgh EH9 3JR, UK
    J Cell Sci 125:411-21. 2012
    ..Our data reveal that functional centromeres in vivo show a remarkable plasticity--kinetochores tolerate profound changes to their chromatin environment, but appear to be critically sensitive to the level of centromeric transcription...
  43. ncbi Apoptosis in the pathogenesis of systemic lupus erythematosus
    L E Munoz
    Department of Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Lupus 17:371-5. 2008
    ..SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications...
  44. pmc Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome
    Xueyan Chen
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 26:843-52. 2007
    ..The role of REGgamma in cell-cycle regulation may extend beyond p21 regulation, because p16(INK4A) and p19(Arf) also bind to REGgamma and are stabilized in REGgamma-deficient cells...
  45. pmc CENP-A confers a reduction in height on octameric nucleosomes
    Matthew D D Miell
    Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    Nat Struct Mol Biol 20:763-5. 2013
    ..We demonstrate that octameric CENP-A nucleosomes assembled in vitro exhibit reduced heights, indicating that they are physically distinct from H3 nucleosomes and negating the need to invoke the presence of hemisomes...
  46. pmc Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival
    J Ren
    Department of Urology, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan, PRC
    Br J Cancer 105:1905-11. 2011
    ..Cancerous inhibitor of protein phosphatase 2A (CIP2A) drives cellular transformation. The objective of this study was to detect the potential effects of CIP2A in renal cell carcinomas (RCCs)...
  47. pmc Autoimmune liver serology: current diagnostic and clinical challenges
    Dimitrios P Bogdanos
    Institute of Liver Studies, King s College London School of Medicine, London SE5 9RS, UK
    World J Gastroenterol 14:3374-87. 2008
    ..Liver diagnostic serology is a fast-expanding area of investigation as new purified and recombinant autoantigens, and automated technologies such as ELISAs and bead assays, become available to complement (or even compete ..
  48. ncbi Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens
    Maurizio Bruschi
    Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genoa, Italy
    J Proteomics 74:2008-17. 2011
    ..Circulating anti α-enolase auto-antibodies can be detected in sera of a significant quota of MGN patients. Like other auto-antigens, α-enolase may be implicated in the pathogenesis of human MGN...
  49. pmc Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression
    Magdalena Murawska
    Institute of Tumor Research and Molecular Biology, Philipps University, Marburg, Germany
    PLoS Genet 7:e1002206. 2011
    ..We suggest that stress-induced chromatin PARylation serves to rapidly attract factors that are required for an efficient and timely transcriptional response...
  50. pmc Condensin regulates the stiffness of vertebrate centromeres
    Susana A Ribeiro
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Biol Cell 20:2371-80. 2009
    ..Loss of stiffness caused by condensin-depletion produces abnormal uncoordinated sister kinetochore movements, leads to an increase in Mad2(+) kinetochores near the metaphase plate and delays anaphase onset...
  51. ncbi Akt phosphorylation of La regulates specific mRNA translation in glial progenitors
    F Brenet
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Oncogene 28:128-39. 2009
    ..Therefore, La appears to be an important contributor to Akt-mediated translational regulation of these transcripts in murine glial cells...
  52. pmc HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly
    Emily A Bassett
    Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 22:749-62. 2012
    ..These data offer insight into the mechanism by which HJURP discriminates CENP-A from bulk histone complexes and chaperones CENP-A/H4 for a substantial portion of the cell cycle prior to mediating chromatin assembly at the centromere...
  53. ncbi CIP2A is associated with human breast cancer aggressivity
    Christophe Come
    Centre for Biotechnology, University of Turku, Turku, Finland
    Clin Cancer Res 15:5092-100. 2009
    ..To investigate the clinical relevance of the recently characterized human oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) in human breast cancer...
  54. pmc Chromogranin A is an autoantigen in type 1 diabetes
    Brian D Stadinski
    Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, Colorado, USA
    Nat Immunol 11:225-31. 2010
    ..This finding extends the list of T cell antigens in type 1 diabetes and supports the idea that autoreactive T cells respond to unusually presented self peptides...
  55. pmc The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases
    C Allmang
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR UK
    Genes Dev 13:2148-58. 1999
    ....
  56. ncbi How the TCR balances sensitivity and specificity for the recognition of self and pathogens
    Gerald P Morris
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:121-8. 2012
    ....
  57. ncbi The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A
    M Runte
    Institut fur Humangenetik, Universitatsklinikum Essen, 45122 Essen, Germany
    Hum Mol Genet 10:2687-700. 2001
    ..As we have not obtained any evidence for other genes in this region, which, from the mouse data appears to be critical for the neonatal Prader-Willi syndrome phenotype, a lack of these snoRNAs may be causally involved in this disease...
  58. pmc Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP
    Hao Hu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Genes Dev 25:901-6. 2011
    ..These findings provide key information for specific recognition of CENP-A and mechanistic insights into the process of centromeric chromatin assembly...
  59. pmc Autoantibodies to tumor-associated antigens: reporters from the immune system
    Eng M Tan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 222:328-40. 2008
    ..The immune system of cancer patients reveals the immune interactive sites or the autoepitopes of participants in tumorigenesis, and this information should be used in the design of immunotherapy...
  60. ncbi CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
    K F Chen
    Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Oncogene 29:6257-66. 2010
    ..In conclusion, inhibition of CIP2A determines the effects of bortezomib on apoptosis and PP2A-dependent Akt inactivation in HCC...
  61. ncbi Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
    J Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Immunity 10:345-55. 1999
    ..These studies reveal that Ikaros proteins are capable of targeting chromatin remodeling and deacetylation complexes in vivo. We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation...
  62. pmc Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
    M Mancini
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 149:603-12. 2000
    ..We propose that the Golgi complex, like mitochondria, senses and integrates unique local conditions, and transduces pro-apoptotic signals through local caspases, which regulate local effectors...
  63. ncbi Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease
    D Roggenbuck
    Institute of Immunology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Gut 58:1620-8. 2009
    ..Autoimmune mechanisms are thought to play a role in the development of Crohn's disease, but the target antigens and the underlying pathways have not been sufficiently identified...
  64. ncbi CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis
    Qian Ze Dong
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
    Ann Surg Oncol 18:857-65. 2011
    ..Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein inhibiting proteolytic degradation of c-MYC. In this study, we investigated the clinical relevance of CIP2A in NSCLC...
  65. pmc Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
    Chyi Ying A Chen
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, Texas, USA
    Nat Struct Mol Biol 16:1160-6. 2009
    ..These findings indicate that promotion of biphasic deadenylation to trigger mRNA decay is an intrinsic property of miRISCs...
  66. pmc Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series
    Meizan Lai
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:776-85. 2010
    ..However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify the real autoantigen associated with limbic encephalitis...
  67. ncbi Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
    A G Uren
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia
    Curr Biol 10:1319-28. 2000
    ..To determine the function of Survivin in mammals, we analyzed the pattern of localization of Survivin protein during the cell cycle, and deleted its gene by homologous recombination in mice...
  68. ncbi Features of systemic lupus erythematosus in Dnase1-deficient mice
    M Napirei
    Abteilung für Anatomie und Embryologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    Nat Genet 25:177-81. 2000
    ..Our findings suggest that lack or reduction of Dnase1 is a critical factor in the initiation of human SLE...
  69. ncbi The La protein
    Sandra L Wolin
    Departments of Cell Biology and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA
    Annu Rev Biochem 71:375-403. 2002
    ..This review focuses on the roles of the La protein in small RNA biogenesis and also discusses data that implicate the La protein in the translation of specific mRNAs...
  70. pmc Immunogenicity of autoantigens
    Christina Backes
    Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany
    BMC Genomics 12:340. 2011
    ..To this end, we have carried out the most comprehensive in-silicio study of different groups of autoantigens including large antigen sets identified by our groups combined with publicly available antigen sets.
  71. pmc An inverse relationship to germline transcription defines centromeric chromatin in C. elegans
    Reto Gassmann
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92037, USA
    Nature 484:534-7. 2012
    ..These findings link centromere identity to transcription and shed light on the evolutionary plasticity of centromeres...
  72. pmc UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
    Marija Sumakovic
    European Neuroscience Institute Goettingen, German Research Foundation Research Center for Molecular Physiology of the Brain, 37077 Goettingen, Germany
    J Cell Biol 186:897-914. 2009
    ..Thus, we propose that RAB-2 and its effector RIC-19 are required for neuronal DCV maturation...
  73. pmc The octamer is the major form of CENP-A nucleosomes at human centromeres
    Dan Hasson
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Struct Mol Biol 20:687-95. 2013
    ..Thus, the fundamental unit of the chromatin that epigenetically specifies centromere location in mammals is an octameric nucleosome with loose termini...
  74. pmc Autoantigens plus interleukin-10 suppress diabetes autoimmunity
    Bela Denes
    Center for Health Disparities and Molecular Medicine, Department of Biochemistry and Microbiology, Loma Linda University, Loma Linda, CA 92350, USA
    Diabetes Technol Ther 12:649-61. 2010
    ..Here we suggest that a vaccinia virus (VV)-mediated combination of CTB::GAD fusion and IL-10 proteins promises a effective and durable immunotherapeutic strategy for T1DM...
  75. pmc A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma
    J Y Zhang
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 189:1101-10. 1999
    ..However, the possible involvement of p62 autoantigen as a factor in the transformation process remains to be elucidated...
  76. pmc Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state
    Andrea Schietinger
    Department of Immunology, University of Washington UW, Seattle, WA 98195, USA
    Science 335:723-7. 2012
    ..These insights into the regulatory mechanisms that maintain or break self-tolerance may lead to new strategies for the treatment of cancer and autoimmunity...
  77. ncbi A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
    P A Wade
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 8:843-6. 1998
    ..This association of a histone deacetylase with a Snf2 superfamily ATPase suggests a functional link between these two disparate classes of chromatin regulators...
  78. ncbi Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway
    Xiaotao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 26:831-42. 2007
    ..Our study reveals that, in addition to degrading the SRC-3 growth coactivator, REGgamma also has a role in the regulation of the cell cycle through its ability to influence the level of a cell-cycle regulator(s)...
  79. ncbi Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis
    Alexei von Delwig
    Newcastle University, Newcastle upon Tyne, UK
    Arthritis Rheum 62:143-9. 2010
    Rheumatoid arthritis (RA) is considered to be a prototypical autoimmune disease. However, the autoantigens that play an important role in the development of RA remain unclear...
  80. pmc CIP2A expression is increased in prostate cancer
    Markku H Vaarala
    Department of Surgery, Oulu University Hospital, PO Box 21, 90029 OYS, Finland
    J Exp Clin Cancer Res 29:136. 2010
    ..Expression of CIP2A has been detected in several carcinomas, but its expression and significance in prostate cancer has not been examined so far...
  81. ncbi A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A
    Anaïck Lagana
    Institute for Research in Immunology and Cancer, Université de Montréal P O Box 6128, Station Centre Ville Montréal QC, H3C 3J7 Canada
    Nat Cell Biol 12:1186-93. 2010
    ..Thus, a small GTPase switch ensures epigenetic centromere maintenance after loading of new CENP-A...
  82. pmc Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens
    S Moses Dennison
    Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Virol 85:1340-7. 2011
    ..cluster I (gp41 amino acids [aa] 579 to 613) or cluster II (gp41 aa 644 to 667) for reactivity to autoantigens, to the gp140 protein, and with MPER peptide-lipid conjugates...
  83. ncbi Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities
    Andreea Ioan-Facsinay
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:188-93. 2011
    ..Likewise, it is unknown to what extent antibody responses to different citrullinated antigens are crossreactive...
  84. pmc Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics
    Yifat Merbl
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 117:712-8. 2007
    ..Thus, the obviously benign autoimmunity prevalent at birth may provide the basis for the emergence of some autoimmune diseases relatively prevalent later in life...
  85. pmc Active establishment of centromeric CENP-A chromatin by RSF complex
    Marinela Perpelescu
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Aichi, Japan
    J Cell Biol 185:397-407. 2009
    ..From these data, we propose the RSF complex as a new factor actively supporting the assembly of CENP-A chromatin...
  86. ncbi La protein binding at the GCAC site near the initiator AUG facilitates the ribosomal assembly on the hepatitis C virus RNA to influence internal ribosome entry site-mediated translation
    Renuka Pudi
    Department of Microbiology and Cell Biology, Indian Institute of Science, Sir C V Raman Avenue, Bangalore 560012, India
    J Biol Chem 279:29879-88. 2004
    ....
  87. pmc Xenopus HJURP and condensin II are required for CENP-A assembly
    Rafael Bernad
    Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    J Cell Biol 192:569-82. 2011
    ..We propose that the chromatin structure imposed by condensin II at centromeres enables CENP-A incorporation initiated by xHJURP...
  88. ncbi BCR/ABL activates mdm2 mRNA translation via the La antigen
    Rossana Trotta
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
    Cancer Cell 3:145-60. 2003
    ..By contrast, La overexpression led to increased MDM2 levels and enhanced resistance to apoptosis. Thus, La-dependent activation of mdm2 translation might represent an important molecular mechanism involved in BCR/ABL leukemogenesis...
  89. pmc Propagation of centromeric chromatin requires exit from mitosis
    Lars E T Jansen
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 176:795-805. 2007
    ....
  90. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders...
  91. ncbi Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    M S Jordan
    The Wistar Institute, Philadelphia, PA 19104, USA
    Nat Immunol 2:301-6. 2001
    ..Our findings indicate that specificity for self-peptides directs the selection of CD4+CD25+ regulatory thymocytes by a process that is distinct from positive selection and deletion...
  92. ncbi The human Mi-2/NuRD complex and gene regulation
    S A Denslow
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Oncogene 26:5433-8. 2007
    ..In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity...
  93. ncbi Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366
    R V Intine
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 6:339-48. 2000
    ..Faithful phosphorylation of hLa on serine 366 reverses this block and promotes tRNA maturation. The results suggest that regulation of tRNA maturation at the level of RNase P cleavage may occur via phosphorylation of serine 366 of hLa...
  94. ncbi Chlamydomonas DIP13 and human NA14: a new class of proteins associated with microtubule structures is involved in cell division
    Frank Pfannenschmid
    Lehrstuhl fur Genetik, Universitat Regensburg, 93040 Regensburg, Germany
    J Cell Sci 116:1449-62. 2003
    ..Thus, DIP13/NA14 could represent the founding members of a new class of highly conserved proteins that are associated with microtubule structures...
  95. ncbi The RNA-binding protein La contributes to cell proliferation and CCND1 expression
    G Sommer
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Oncogene 30:434-44. 2011
    ..In conclusion, this study establishes a role of La in cell proliferation and CCND1 expression and demonstrates for the first time an overexpression of the RNA-binding protein La in solid tumors...
  96. pmc Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis
    A Kubo
    Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo ku, Kyoto 600 8813, Japan
    J Cell Biol 147:969-80. 1999
    ..These findings suggested that centriolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication...
  97. ncbi Autoantibodies and their antigens in autoimmune hepatitis
    Dimitrios P Bogdanos
    Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, London SE5 9RS, United Kingdom
    Semin Liver Dis 29:241-53. 2009
    ....
  98. ncbi Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid
    Giovanni Di Zenzo
    Istituto Dermopatico dell Immacolata, Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    Clin Immunol 128:415-26. 2008
    ..These results demonstrate the usefulness of the combined ELISAs based on various BP180 and BP230 fragments in establishing the diagnosis of BP and support the concept that BP180 is the major autoantigen of BP...
  99. pmc Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9
    Robyn E Mansfield
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
    J Biol Chem 286:11779-91. 2011
    ....
  100. pmc Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance
    Ralph Marvin Steinman
    Laboratories of Cellular Physiology and Immunology, and Molecular Immunology and Howard Hughes Institute, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 99:351-8. 2002
    ..The function of DCs in defining immunologic self provides a new focus for the study of autoimmunity and chronic immune-based diseases...
  101. pmc Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA
    Katherine L D Hands-Taylor
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Nucleic Acids Res 38:4052-66. 2010
    ....

Research Grants71

  1. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..It is unknown what effect this partial chronic sleep disruption has on the immune mediated flares from new autoantigens on the arthritic processes of RA and related arthritides...
  2. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..My immediate goals for the duration of the award are 1) to acquire the necessary skills to identify pathogenic autoantigens and the T cells that recognize them;2) to obtain guidance for maturation as a scientist and my preparation for ..
  3. Gene Transcription in SLE
    George C Tsokos; Fiscal Year: 2012
    ..Successful completion will introduce additional mechanisms that lead to the generation of autoantigens that drive autoimmunity...
  4. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..We will further characterize immune responses to the TSHR and other thyroid autoantigens in mice with thyroid infiltrates...
  5. Proteome Bead-Display for Discovery of Tumor Antigens
    Mark Lim; Fiscal Year: 2013
    ..One of the most promising candidates for such biomarkers is tumor-associated autoantigens (TAA), autoantibodies to which have been detected in patient's blood even in the early stages of cancer...
  6. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ..a non-specific stimulator of the innate immune system), collagen II/CFA or HCgp39/CFA (two joint-related autoantigens in RA) that activate the adaptive immune system, and to develop in vivo monitoring protocols using a ..
  7. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..are generated by the activation of cross-reactive T cells to environmental antigens and lupus related autoantigens in a HLA-DR restricted fashion...
  8. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ..neuropsychiatric disorders have resulted in the discovery of 6 novel immune responses to cell surface/synaptic autoantigens, including among others the GluR1/2 subunits of the AMPA receptor (AMPAR), the GABA(B1) receptor (GABA(B1)R), ..
  9. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2013
    ..signaling, exogenous signals from the innate immune system and T cell help in the initial loss of tolerance to autoantigens and in the perpetuation of the anti- phospholipid response...
  10. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ..neuropsychiatric manifestations have led to the discovery of 4 novel immune responses to cell surface/synaptic autoantigens, including, among others, the GluR1/2 subunits of the AMPA receptor, and the GABA(B1) receptor...
  11. The role of neutrophil extracellular traps and NADPH oxidase in SLE pathogenesis
    ALLISON MARIE CAMPBELL; Fiscal Year: 2012
    ..Though several groups studying NETs have suggested they may provide lupus autoantigens in vivo, paradoxically, it has been observed that humans with an X-linked defect in NADPH oxidase and hence ..
  12. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    FELIX RODOLFO FERNANDEZ MADRID; Fiscal Year: 2010
    Development and validation of a panel of breast cancer autoantigens for the early diagnosis of breast cancer Abstract Detection of the early stages of breast cancer is one of the pillars of successful therapy and the identification of ..
  13. MECHANISMS OF AUTOIMMUNITY IN SLE
    David Stephen Pisetsky; Fiscal Year: 2013
    ..Specifically, we will explore the role of nuclear molecules as autoadjuvants and autoantigens in the context of microparticles...
  14. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..experimental autoimmune models have demonstrated clinical efficacy in that expression of Ig fusion proteins of autoantigens by B cells can both prevent and reverse autoimmune responsiveness...
  15. Mannose Binding Lectin in Neuroinflammation and NeuroAIDS
    Kumud K Singh; Fiscal Year: 2013
    ..increased susceptibility to HIV-1 infection and neuroinflammation, accumulation of viral/complement proteins or autoantigens in brain, and eventually neurocognitive impairment...
  16. Post Translational Modifications in Tolerance and Autoimmunity
    Mark J Mamula; Fiscal Year: 2012
    ..We have previously identified the presence of isoaspartyl modifications in two lupus autoantigens, the snRNP ribonucleoprotein and histone H2B...
  17. The Contribution of Protein Methylation in Systemic Lupus Erythematosus
    Hester A Doyle; Fiscal Year: 2011
    ..protein methylated self-antigens are processed for antigen presentation by digesting the known modified lupus autoantigens snRNP, histone H2B, and symmetrical dimethylarginine Sm D1 and D3 with enzymes involved in antigen processing ..
  18. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
    ..Since the effect of GILT is not limited to the presentation of TRP1 or cutaneous autoantigens, modulation of GILT expression or activity may be a broadly applied therapeutic approach for autoimmune disease. ..
  19. Identification of CNS-homing peptides for therapeutic use in multiple sclerosis
    Kamal D Moudgil; Fiscal Year: 2013
    ..A variety of autoantigens, including myelin oligodendrocyte glycoprotein (MOG), proteolipid protein (PLP), and myelin basic protein (MBP) ..
  20. Chemokines and Lymphoid Tissue Organization and Function
    Jason G Cyster; Fiscal Year: 2013
    ..for development of improved vaccines and may suggest novel approaches for reducing unwanted responses to autoantigens or allergens...
  21. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2009
    ..signaling, exogenous signals from the innate immune system and T cell help in the initial loss of tolerance to autoantigens and in the perpetuation of the anti-phospholipid response...
  22. Immunological Mechanisms in Systemic Autoimmune Disease
    Ann Marshak-Rothstein; Fiscal Year: 2012
    ..The specific aims of the application are as follows: (1) Determine whether the autoantigens routinely associated with SSc can activate B cells and/or dendritic cells, and if so, whether they are ..
  23. A protein array platform for anti-citrulline antibodies in Rheumatoid Arthritis
    Ji Qiu; Fiscal Year: 2013
    ..protein antibodies in RA at the proteome level and to map immuno-dominant epitopes of citrullinated autoantigens on array with the key advantages being high-throughput, multiplexed, quantitative, and low-cost so that enough ..
  24. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..and specificity requirements for the bleb and AMA and use a proteomic approach to identify additional autoantigens unique to BEC. In addition, we will determine if other mononuclear cells, e.g...
  25. dnTGF Beta RII Mice and PBC
    William M Ridgway; Fiscal Year: 2013
    ..the study of PBC, work which began nearly 25 years ago with the identification and cloning of the mitochondrial autoantigens. However, a breakthrough in PBC requires an animal model and over the past several years our laboratory has ..
  26. CD1 presentation of self glycolipids and lipopeptides to T cells
    DAVID BRANCH MOODY; Fiscal Year: 2013
    ..by applicant): CD1 presentation of self glycolipids and lipopeptides to T cells T cells that recognize autoantigens play a central role in psoriasis, thyroiditis, diabetes, multiple sclerosis, rheumatoid arthritis and other ..
  27. Exosome-induced innate and antigen-specific immune responses in Type 1 Diabetes
    Yang D Dai; Fiscal Year: 2013
    ..This suggests that islet autoantigens and their short peptides presented on the MHC molecules are the key elements leading to the destruction of the ..
  28. Definition of Serum Ribonucleoprotein Composition and its Regulation and Function
    Thomas Tuschl; Fiscal Year: 2013
    ..Identify the RNA targets and RNP structures of autoantigens in tRNA stress responses, their turnover, and their immune receptors.
  29. Specificity of CD8 cells in islets from type 1 diabetes patients
    Matthias G Von Herrath; Fiscal Year: 2013
    ..Possible targets are known autoantigens derived from beta cells such as insulin, IGRP, IA-2 and GAD (see Table 1 for abbreviations) and cellular matrix ..
  30. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Eric L Greidinger; Fiscal Year: 2011
    ..Immunity to snRNP autoantigens, including the Smith (Sm) and the U1-70RD polypeptide of the ribonucleoprotein (RNP) antigen, appears to have a ..
  31. Mechanisms of Autoimmune Activation and Regulation by Innate Immune Receptors
    Mark J Shlomchik; Fiscal Year: 2013
    ..provided by applicant): The autoantibody response in systemic autoimmune diseases focuses on a specific set of autoantigens, but it is not clear why...
  32. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2012
    ..the phenotype of infiltrating cells and their cytokine, d) define the specificity of infiltrating T cells to autoantigens collagen V and K-11 tubulin, and e) determine the autoantigenic epitopes for helper T cell stimulation and Ab ..
  33. Program Project for Mechanisms and Treatment of Arthritis
    John M Stuart; Fiscal Year: 2013
    ..Once inflammation and arthritis have developed, they are perpetuated by ongoing autoimmune reactions. Several autoantigens have been identified that may be responsible for this process but the relative importance of particular ..
  34. Antigen Identification in a Novel Model of Spontaneous Autoimmune Ovarian Disease
    Mickie H Cheng; Fiscal Year: 2012
    ..Aim 2: To identify ovarian autoantigens targeted in aire-deficient mice. Aim 3: To establish clinical correlations of disease markers in AOD...
  35. PATHOGENESIS OF AUTOANTIBODIES IN PRISTANE-INDUCED LUPUS
    Westley H Reeves; Fiscal Year: 2013
    ..bone marrow chimeras and knockout mice, Aim 1 will define the roles of TLR7, IRF5/7, and the IFNAR as well as autoantigens released from dying cells in autoantibody and IFN-I production...
  36. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2012
    ..by applicant): In systemic autoimmune diseases, B cells secrete pathogenic autoantibodies and also present autoantigens to autoreactive T cells...
  37. Interferons and cytotoxic lymphocytes in dermatomyositis and cutaneous lupus
    DAVID FRANKLIN FIORENTINO; Fiscal Year: 2013
    ..Our preliminary studies show that there are novel type I and/or type II IFN-inducible autoantigens targeted in DM and SLE (such specificities are undetected in conventional antibody screens) and provide ..
  38. Small Molecules Targeting Allele Specific MHC Class II Presentation
    Aaron W Michels; Fiscal Year: 2013
    ..By targeting MHC class II molecules, it is possible to use small molecules to block the presentation of autoantigens to T cells while other molecules can stimulate the production of protective cytokines (e.g. IL10)...
  39. Immunologic mechanisms in post-Lyme disease syndrome
    Armin Alaedini; Fiscal Year: 2011
    ..aims: 1) To characterize the specificity and pattern of reactivity of the observed antibody response to autoantigens;2) To determine the specificity and cross-reactivity of the discovered differential immune response to B...
  40. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..The precursor frequencies of T cells specific for OspA163-i75 or implicated autoantigens will be determined in both the infectious and post-antibiotic periods of the illness, the clonal ..
  41. Mechansim of activation of innate immunity by ISS-DNA
    Wen Ming Chu; Fiscal Year: 2013
    ..Intriguingly, both HMGB1 and Ku proteins are autoantigens of SLE, and autoantibodies against both of them are present in the serum of some SLE patients...
  42. Environmental Control of the Immunological Synapse
    MICHAEL LORAN DUSTIN; Fiscal Year: 2013
    ..and STOP and Treg PKC-8 signals lead to failure of peripheral tolerance to low potency ligands that can become autoantigens in the context of tissue injury or inflammatory stimuli...
  43. Characterization of a novel C1q-dependent engulfment pathway in autoimmunity
    Suzanne Slater Bohlson; Fiscal Year: 2013
    ..associated with the inefficient disposal of apoptotic cells, whih are considered the major source of lupus autoantigens. Complement component C1q triggers engulfment of apoptotic cells (efferocytosis), and deficiency in C1q is the ..
  44. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..Sm peptide immunization with epitope spreading and genesis of autoantibodies to other parts of the Sm and nRNP autoantigens, as well as positive ANA and antibodies to DNA...
  45. Role of chemokines in diabetes
    Sergio A Lira; Fiscal Year: 2013
    ..We hypothesize that the trafficking of DC carrying autoantigens produced during the initial inflammatory process into the peripancreactic lymph nodes is dependent on CCR7...
  46. Paraneoplastic Disorders of the CNS: Autoantigen Profiling
    Josep O Dalmau; Fiscal Year: 2013
    ..This proposal is an extension of this work and focuses on the comprehensive identification of autoantigens in four disorders: 1) rapidly progressive dementia with CSF inflammatory/autoimmune features, 2) opsoclonus-..
  47. Tertiary lymphoid neogenesis in human lupus nephritis
    Marcus R Clark; Fiscal Year: 2012
    ..that lupus tubulointerstitial nephritis is not a manifestation of systemic autoimmunity to ubiquitous autoantigens. Rather, it might result from a break in tolerance to locally expressed antigens...
  48. Induced Autoantigen Expression Exacerbates EAE
    Kenneth L Bost; Fiscal Year: 2011
    ..as macrophages, dendritic cells, and B lymphocytes might serve as professional antigen presenting cells for autoantigens. The presence of auto-reactive CD4+ T lymphocytes will also be determined in the peripheral tissues and in the ..
  49. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2013
    ..Given these findings, we hypothesize that ps1 delivered autoantigens can induce tolerance and is sialic acid binding-dependent, and tolerance is facilitated via apoptosis of target ..
  50. Discovery of Novel Autoantigens in Patients with Inclusion Body Myositis
    KEVIN C O'CONNOR; Fiscal Year: 2013
    ..these single cells will be tested for reactivity to muscle intermediate filament proteins and other candidate autoantigens. In the second part of the project, the sero-prevalence of IBM autoantibodies will be determined...
  51. Proteomic Analyses of Pediatric Systemic Lupus Erythematosus
    IMELDA MARIE BALBONI; Fiscal Year: 2013
    ..in pSLE correlates with the presence of autoantibodies directed against specific nucleic-acid-containing autoantigens;and 3. histone modifications occurring in pSLE patients serve as unique targets for autoreactivity...
  52. Defining genetic pathways to severe systemic autoimmunity
    Edward K Wakeland; Fiscal Year: 2010
    ..leading to B cell expansions in vivo and increased production of IgM autoantibodies recognizing a variety of autoantigens. We have produced a series of truncated congenic strains across the S/e3 and S/e5 congenic intervals that will ..
  53. Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Michael J Stern; Fiscal Year: 2010
    ..Our central hypothesis is that desiccating ocular surface stress reveals autoantigens in the ocular surface epithelia that initiate a tissue specific T cell response which causes dysfunction and ..
  54. Estrogen Receptor a Regulation of Lupus Development and Pathogenesis
    Karen A Gould; Fiscal Year: 2013
    ..and to determine the cell types and pathways through which estrogens augment the immune response to nuclear autoantigens. A long term goal of our laboratory is to understand how genetic and hormonal factors interact to influence ..
  55. Prolactin as a lacrimal gland immunomodulator
    Joel Schechter; Fiscal Year: 2009
    ..A by-product of the sIgA delivery mechanism is the release of autoantigens. Certain paracrine mediators tend to enforce tolerance to the autoantigens, while others are potentially pro-..
  56. Rheumatic Disease Sera: Probes of Disease Mechanisms
    Livia A Casciola-Rosen; Fiscal Year: 2012
    ..Recent studies have demonstrated that autoantigens in myositis are expressed at high levels in inflamed muscle, particularly in regenerating muscle cells...
  57. ISLET CELL MEMBRANE ANTIBODIES IN DIABETES
    Christiane S Hampe; Fiscal Year: 2013
    ..Autoantigen-Fc fusion proteins of all four major autoantigens (insulin, GAD65, IA-2, and ZnT8) will be used in this approach...
  58. Novel Neutrophil Autoantigens in Systemic Lupus Erythematosus
    Kaihong Su; Fiscal Year: 2013
    ..Results from our studies will identify potential bio-markers for prediction of tissue damage in SLE and also help to develop novel preventive and therapeutic interventions for tissue damage in SLE patients. ..
  59. UNIQUE SURFACE STRUCTURES ON SYNOVIAL CELLS
    DAVID ALAN FOX; Fiscal Year: 2011
    ..Our work has shown that FLS can function as APCs, even for presentation of peptides from arthritogenic autoantigens to clonal T cell populations in an MHC- restricted manner...
  60. Cloning of molecular targets of Cell Mediated Autoimmunity in Type 1 Diabetes
    Howard W Davidson; Fiscal Year: 2013
    ..We anticipate that our results will confirm that both autoantigens can be effective therapeutic targets in NOD mice, both early and late during diabetogenesis, and will provide ..
  61. The Role of IGRP in the Pathogenesis of Type 1 Diabetes
    RICHARD M O apos BRIEN; Fiscal Year: 2010
    ..reactive T-cells persist in these animals and the impact on the autoimmune response directed at other islet autoantigens (ii) gene rescue experiments to determine whether re-introduction of IGRP as a BAG or cDNA restores diabetes ..
  62. Mechanisms of B Cell Survival and Death
    Roberta Pelanda; Fiscal Year: 2011
    ..Recent studies in mice indicate that newly generated immature B cells that react with autoantigens in the bone marrowundergo receptor editing and anergy, and that receptor editing contributes to a significant ..
  63. Specialized Center of Research in Systemic Lupus Erythe*
    Shu Man Fu; Fiscal Year: 2006
    ..been obtained regarding the mechanism of epitope spreading in the autoantibody diversification to SLE-related autoantigens. The identification of crossreactive T cells is a major advance in the understanding of this process...
  64. VACCINIA VIRUS VACCINE FOR TYPE 1 DIABETES
    William Langridge; Fiscal Year: 2003
    ..disease that is partially suppressed by oral administration of small amounts of insulin or other diabetes autoantigens. To strengthen this promising immunotolerization approach to diabetes prevention, new innovative strategies are ..
  65. ROLE OF ANTI-PROTEINASE-3 IN WEGENER'S VASCULOPATHY
    Judith James; Fiscal Year: 2003
    ..Over the past decade our lab has conducted extensive work on the immunochemistry of lupus autoantigens (1-7). These previous studies provide the technical background for this proposal...
  66. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2009
    ..question concerning spontaneous organ specific autoimmune disorders is whether there exist essential target autoantigens such that deletion of an immune response to one or more of such targets will abrogate disease...
  67. Prevention of Type I Diabetes Mellitus using a Cell Vac*
    Nick Giannoukakis; Fiscal Year: 2002
    ..animals to date have focused on the induction of tolerance to either soluble islet antigens or putative autoantigens like insulin and glutamic acid decarboxylase...
  68. MULTILPLE AUTOANTIGENS OF PRETYPE I DM
    George Eisenbarth; Fiscal Year: 1999
    ..3) Finish the sequencing of the PM-1 molecule and with PM-1, carboxypeptidase H and synaptophysin analyze the relationship of autoantibodies to these peptides and restricted ICA and disease progression. ..
  69. Tolerance to the Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2006
    ..Yet, the majority of autoantigens, like La/SS-B, targeted in the systemic autoimmune diseases Sjogren?s syndrome and systemic lupus erythematosus ..
  70. New Approaches to the Biology and Treatment of Myelodysplastic Syndromes (MDS)
    Hagop Kantarjian; Fiscal Year: 2009
    ..Molldrem's hypothesis that peptides derived from normal tissue proteins can be autoantigens for cytotoxic T-lymphocytes (CTL) if peptide overexpression breaks immune tolerance...
  71. NOD T CELL RECEPTORS FOR SPECIFIC ISLET AUTOANTIGENS
    Eric Simone; Fiscal Year: 2000
    ..3a TCR peptides selected from the polymorphic CDR regions or V(alpha)13.3 DNA constructs, in an attempt to eliminate or immunomodulate endogenous V(alpha)13.3a containing T cells that are potentially autoreactive. ..