Summary: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Top Publications

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  2. pmc House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Nat Med 15:410-6. 2009
  3. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
  4. ncbi The asthma epidemic
    Waltraud Eder
    University Children s Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  5. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  6. pmc Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
  7. pmc A mechanism for the initiation of allergen-induced T helper type 2 responses
    Caroline L Sokol
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connceticut 06510, USA
    Nat Immunol 9:310-8. 2008
  8. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
  9. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
  10. ncbi Allergenic pollen and pollen allergy in Europe
    G D'Amato
    Division of Respiratory and Allergic Diseases, Department of Chest Diseases, High Speciality Hospital A Cardarelli Napoli, Italy
    Allergy 62:976-90. 2007

Detail Information

Publications394 found, 100 shown here

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  2. pmc House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Nat Med 15:410-6. 2009
    ..Our data identify an innate immune function of airway epithelial cells that drives allergic inflammation via activation of mucosal DCs...
  3. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals; in contrast, there is a high frequency of allergen-specific IL-4-secreting T cells in ..
  4. ncbi The asthma epidemic
    Waltraud Eder
    University Children s Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  5. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  6. pmc Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
    ..Why particular proteins tend to act as allergens in susceptible hosts is a fundamental mechanistic question that remains largely unanswered...
  7. pmc A mechanism for the initiation of allergen-induced T helper type 2 responses
    Caroline L Sokol
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connceticut 06510, USA
    Nat Immunol 9:310-8. 2008
    Both metazoan parasites and simple protein allergens induce T helper type 2 (TH2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown...
  8. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
    ..The opposing effects of C3a and C5a were mediated through their reciprocal regulation of IL-23 production. These data demonstrate a critical role for complement-mediated regulation of the IL-23-T(H)17 axis in severe asthma...
  9. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ..In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic ..
  10. ncbi Allergenic pollen and pollen allergy in Europe
    G D'Amato
    Division of Respiratory and Allergic Diseases, Department of Chest Diseases, High Speciality Hospital A Cardarelli Napoli, Italy
    Allergy 62:976-90. 2007
  11. ncbi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
    ..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
  12. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    ..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
  13. pmc The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Negl Trop Dis 6:e1593. 2012
    ..In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens.
  14. pmc A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming
    Padraic G Fallon
    Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Nat Genet 41:602-8. 2009
  15. ncbi Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
    E M Hollams
    Telethon Institute for Child Health, 100 Roberts Road, Subiaco WA 6008, Australia
    Eur Respir J 38:1320-7. 2011
    ..In a large unselected cohort, males with inadequate vitamin D at 6 and 14 yrs of age had increased atopy and BHR. Low vitamin D at age 6 yrs was a predictor of atopy and asthma at 14 yrs of age...
  16. ncbi Pathophysiology of allergic inflammation
    Peter J Barnes
    National Heart and Lung Institute, Imperial College, London, UK
    Immunol Rev 242:31-50. 2011
    ..Corticosteroids are highly effective with a broad spectrum of anti-inflammatory effects, including epigenetic modulation of the inflammatory response and suppression of GATA3...
  17. ncbi Epicutaneous allergen-specific immunotherapy ameliorates grass pollen-induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study
    Gabriela Senti
    Clinical Trials Center, University Hospital Zurich, Zurich, Switzerland
    J Allergy Clin Immunol 129:128-35. 2012
    ..Epicutaneous allergen administration using a patch may be an alternative to subcutaneous or sublingual immunotherapy...
  18. ncbi Allergen-specific immunotherapy with recombinant grass pollen allergens
    Marek Jutel
    Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland
    J Allergy Clin Immunol 116:608-13. 2005
    ..Recombinant DNA technology has enabled the cloning of many allergens, thus facilitating investigations aimed at improving efficacy and safety of immunotherapy.
  19. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    The regulation of normal and allergic immune responses to airborne allergens in the mucosa is still poorly understood, and the mechanism of specific immunotherapy (SIT) in normalizing the allergic response to such allergens is currently ..
  20. ncbi Immunological mechanisms of allergen-specific immunotherapy
    Mark Larché
    Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Nat Rev Immunol 6:761-71. 2006
    ..Approaches to address this problem include the use of modified allergens, novel adjuvants and alternative routes of administration...
  21. ncbi Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
    Jill R Johnson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    Am J Respir Crit Care Med 169:378-85. 2004
    ..Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly...
  22. ncbi Loosening of plant cell walls by expansins
    D J Cosgrove
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Nature 407:321-6. 2000
    ..Expansin's action has puzzling implications for plant cell-wall structure. The recent explosion of gene sequences and expression data has given new hints of additional biological functions for expansins...
  23. ncbi Defining a link with asthma in mice congenitally deficient in eosinophils
    James J Lee
    Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Science 305:1773-6. 2004
    ..The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis...
  24. pmc The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
    Hideaki Kouzaki
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 186:4375-87. 2011
    ..ATP and purinergic signaling in the respiratory epithelium are critical sensors for airway exposure to airborne allergens, and they may provide novel opportunities to dampen the hypersensitivity response in Th2-type airway diseases ..
  25. pmc Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts
    Karin C Lødrup Carlsen
    Department of Paediatrics, Oslo University Hospital, Ulleval, Norway
    PLoS ONE 7:e43214. 2012
    ..To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6-10 years...
  26. pmc Mesenteric lymph node transcriptome profiles in BALB/c mice sensitized to three common food allergens
    Mainul Husain
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    BMC Genomics 12:12. 2011
    ..Therefore, the present study analyzed the mesenteric lymph node (MLN) transcriptome profiles of BALB/c mice in response to three common food allergens.
  27. ncbi Allergens and their role in the allergic immune response
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Immunol Rev 242:51-68. 2011
    b>Allergens are recognized as the proteins that induce immunoglobulin E (IgE) responses in humans. The proteins come from a range of sources and, not surprisingly, have many different biological functions...
  28. ncbi Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    N Mothes
    Department of Pathophysiology, Vienna General Hospital, University of Vienna, Vienna, Austria
    Clin Exp Allergy 33:1198-208. 2003
    ..The allergen extract-based analyses of immunotherapy-induced effects yielded highly controversial results regarding a beneficial role of therapy-induced IgG antibodies...
  29. ncbi Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1
    Yan Ma
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 139:53-62. 2006
    ..The objective of the present study was to evaluate whether this concept was applicable for the Bet v 1-homologous apple allergen, Mal d 1...
  30. ncbi Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
    Gail M Gauvreau
    McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 183:1007-14. 2011
    ..Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that bind to different epitopes and neutralize IL-13 bioactivity...
  31. ncbi Long-term clinical efficacy of grass-pollen immunotherapy
    S R Durham
    Department of Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    N Engl J Med 341:468-75. 1999
    ..Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment...
  32. pmc Hazelnut (Corylus avellana) vicilin Cor a 11: molecular characterization of a glycoprotein and its allergenic activity
    Iris Lauer
    Department of Allergology, Paul Ehrlich Institut, Langen, Germany
    Biochem J 383:327-34. 2004
    In Europe, hazelnuts (Corylus avellana) are a frequent cause of food allergies. Several important hazelnut allergens have been previously identified and characterized...
  33. ncbi Distribution and determinants of house dust mite allergens in Europe: the European Community Respiratory Health Survey II
    Jan Paul Zock
    Center for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain
    J Allergy Clin Immunol 118:682-90. 2006
  34. ncbi Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
    T Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
    Lancet 357:752-6. 2001
    Although asthma is strongly associated with immediate hypersensitivity to indoor allergens, several studies have suggested that a cat in the house can decrease the risk of asthma...
  35. ncbi Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study
    T Werfel
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    Allergy 61:202-5. 2006
    ..Therefore, a multi-centre, randomized dose-response trial, double-blind with respect to the efficacy of a biologically standardized depot house dust mite preparation was performed...
  36. ncbi Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates
    J Heinrich
    GSF Institute of Epidemiology, National Research Centre for Environment and Health, Neuherberg, Germany
    Eur Respir J 20:617-23. 2002
    ..35 kU x L(-1) was used as cut-off. These results, showing an association between prenatal allergen and endotoxin exposures and immunoglobulin E production, suggest that the development of foetal immune responses may be affected...
  37. ncbi Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
    Fabien Schmidlin
    Department of Surgery and Physiology, University of California, San Francisco 94143, USA
    J Immunol 169:5315-21. 2002
    ..Thus, PAR2 contributes to the development of immunity and to allergic inflammation of the airway. Our results support the proposal that tryptase inhibitors and PAR2 antagonists may be useful therapies for inflammatory airway disease...
  38. pmc Group I allergens of grass pollen as cell wall-loosening agents
    D J Cosgrove
    Department of Biology, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 94:6559-64. 1997
    Group I allergens are the major allergens of grass pollen, but their biological function is unknown. These proteins are shown here to be structurally related to expansins, which are able to induce extension (creep) of plant cell walls...
  39. ncbi The role of protein glycosylation in allergy
    Friedrich Altmann
    Divison of Biochemistry, Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Int Arch Allergy Immunol 142:99-115. 2007
    ..and suppress anti-CCD IgE without interference from peptide epitopes can be best met by artificial glycoprotein allergens. Hydroxyproline-linked arabinose (single beta-arabinofuranosyl residues) has been identified as a new IgE-..
  40. ncbi The spectrum of fungal allergy
    Birgit Simon-Nobbe
    Department of Cell Biology, University of Salzburg, Salzburg, Austria
    Int Arch Allergy Immunol 145:58-86. 2008
    ..Nonetheless, about 150 individual fungal allergens from approximately 80 mold genera have been identified in the last 20 years...
  41. ncbi Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens
    Mirela Curin
    Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 154:258-63. 2011
    Commercial skin prick test (SPT) extracts used for the diagnosis of dog allergy are prepared by extracting allergens from natural sources, e.g. dog hair and dander...
  42. ncbi Morphology changes in human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM₁.₀) and pollen allergens
    V Esposito
    Department of Medicine and Public Health, Section of Human Anatomy, Second University of Naples, Italy
    Environ Pollut 171:162-7. 2012
    ..These observations demonstrate morphological and functional alterations related to the PM(1.0) and P. officinalis and confirm the induction of the inflammatory response in lung cells exposed to the inhalable particles...
  43. ncbi The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands
    Jesper E Mogensen
    Department of Biotechnology, Institute of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, Aalborg DK 9000, Denmark
    J Biol Chem 277:23684-92. 2002
    ..This study provides the first qualitative and quantitative data on the ligand binding properties of this important pollen allergen. Our findings indicate that ligand binding is important for the biological function of Bet v 1...
  44. ncbi IgE-binding epitopes: a reappraisal
    R C Aalberse
    Department of Immunopathology, Sanquin Research and Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:1261-74. 2011
  45. pmc Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite
    Mohamed Emara
    School of Molecular Medical Sciences, Queen s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 287:5756-63. 2012 play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differentiation have remained ..
  46. ncbi Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM₁.₀) and pollen allergens
    G Mazzarella
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Italy
    Environ Pollut 161:64-9. 2012
    ..0) + ALL together, but is higher expressed when the cells are treated only with the allergen. Our data support the hypothesis that the urban environment damage the acinar lung units and activates cells of the immune system...
  47. ncbi Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy?
    K A B M Peeters
    Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Clin Exp Allergy 37:108-15. 2007
    Recognition of specific peanut allergens or the diversity of IgE binding to peanut allergens may play a role in the elicitation of severe allergic reactions.
  48. pmc Transient dimers of allergens
    Juha Rouvinen
    Department of Chemistry, University of Eastern Finland, Joensuu, Finland
    PLoS ONE 5:e9037. 2010
    ..If an allergen is a homodimer, its allergenicity is enhanced because it would only need one type of antibody, instead of two, for cross-linking...
  49. ncbi Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
    Gabrielle Pauli
    University Hospital, Strasbourg, France
    J Allergy Clin Immunol 122:951-60. 2008
    ..Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition...
  50. pmc Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
    Erik Wambre
    Benaroya Research Institute at Virginia Mason, Seattle, Wash 98101, USA
    J Allergy Clin Immunol 129:544-51, 551.e1-7. 2012
  51. ncbi Bioaerosol health effects and exposure assessment: progress and prospects
    J Douwes
    Institute for Risk Assessment Sciences IRAS, Division of Environmental and Occupational Health, Utrecht University, The Netherlands
    Ann Occup Hyg 47:187-200. 2003
    ..Non-culture methods and assessment methods for microbial constituents [e.g. allergens, endotoxin, beta(1-->3)-glucans, fungal extracellular polysaccharides] appear more successful; however, ..
  52. ncbi Key pollen allergens in North America
    Jason F White
    University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0563, USA
    Ann Allergy Asthma Immunol 91:425-35; quiz 435-6, 492. 2003
    ..To discuss major pollen aeroallergens in North America that are essential for effective immunotherapy and to propose a list of pollen aeroallergens that could be prioritized for allergen standardization...
  53. ncbi Microarrayed recombinant allergens for diagnostic testing
    Wayne G Shreffler
    Food Allergy Center and Center for Immunology and Inflammatory Diseases at Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Allergy Clin Immunol 127:843-9; quiz 850-1. 2011
    The development of protein microarray-based immunoassays and the availability of recombinant allergens have, to a significant extent, emerged together over the past decade...
  54. ncbi Allergens to wheat and related cereals
    A S Tatham
    Cardiff School of Health Sciences, University of Wales Institute Cardiff, Cardiff, UK
    Clin Exp Allergy 38:1712-26. 2008
    ..Processing of wheat and of related cereals (barley and rye, which may contain related allergens) may lead to decreased allergenicity while genetic engineering technology offers opportunities to eliminate ..
  55. pmc Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma
    E C Matsui
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Allergy 65:1414-22. 2010
    ..Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic...
  56. ncbi Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 126:638-45.e1. 2010
    ..Oral mucosal Langerhans cells (oLCs) play a central role. However, little is known about allergen binding by oLCs during mucosal allergen resorption and its impact on oLC functions...
  57. ncbi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
    ..Their identification as key regulators of immunologic processes in peripheral tolerance to allergens has opened an important era in the prevention and treatment of allergic diseases...
  58. ncbi Selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology
    T Kleber-Janke
    Research Center Borstel, Germany
    Int Arch Allergy Immunol 119:265-74. 1999
    Peanut kernels contain many allergens able to elicit IgE-mediated type 1 allergic reactions in sensitized individuals. Sera from sensitized patients recognize variable patterns of IgE-binding proteins...
  59. ncbi Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D
    Roona Deb
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 282:36808-19. 2007
    ..They interact with a wide range of inhaled allergens, competing with their binding to cell-sequestered IgE resulting in inhibition of mast cell degranulation, and ..
  60. pmc Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family
    Iain W Chalmers
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 9:89. 2008
    ..protein/Tpx-1/Ag5/PR-1/Sc7 (SCP/TAPS) domain is found across phyla and is a major structural feature of insect allergens, mammalian sperm proteins and parasitic nematode secreted molecules...
  61. ncbi Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach
    G Frank Gerberick
    The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45252, USA
    Toxicol Sci 97:417-27. 2007
    ..One unifying characteristic of chemical allergens is the requirement that they react with proteins for the effective induction of skin sensitization...
  62. ncbi Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier
    Zora Markovic-Housley
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 325:123-33. 2003
    ..The role of BRs transport in PR-10 proteins may be of crucial importance in the plant defense response to pathological situations as well as in growth and development...
  63. ncbi The spectrum of allergens in ragweed and mugwort pollen
    Nicole Wopfner
    Department of Molecular Biology, Division of Allergy and Immunology, University of Salzburg, Salzburg, Austria
    Int Arch Allergy Immunol 138:337-46. 2005
    ..Amb a 1 and Art v 1, the major allergens of ragweed and mugwort, respectively, are unrelated proteins...
  64. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
    ..exposure in beekeepers by natural bee stings represents a model to understand mechanisms of T cell tolerance to allergens in healthy individuals...
  65. ncbi Environmental exposure to endotoxin and its relation to asthma in school-age children
    Charlotte Braun-Fahrlander
    Institute of Social and Preventive Medicine, Basel, Switzerland
    N Engl J Med 347:869-77. 2002
    ..Immune activation may direct the immune response, thus conferring tolerance to allergens such as animal dander or tree and grass pollen.
  66. ncbi Preventive and therapeutic effects of oral tolerance in a murine model of asthma
    Yeonseok Chung
    Laboratory of Immunology, College of Pharmacy, Seoul National University, Korea
    Immunobiology 206:408-23. 2002
    ..These results demonstrate that allergic asthma may be ameliorated by feeding allergen; there is hope that these results will provide a new immunotherapeutic strategy for allergic asthma...
  67. ncbi A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model
    William R Henderson
    Departments of Medicine and Pathology, University of Washington, Seattle, Washington 98195 6523, USA
    Am J Respir Crit Care Med 165:108-16. 2002
    ..These data suggest an important role for cysteinyl leukotrienes in the pathogenesis of chronic allergic airway inflammation with fibrosis...
  68. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
    ..This can be carried out applying the test in the routine diagnostic work-up...
  69. ncbi Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, New York, NY 10029, USA
    J Allergy Clin Immunol 123:43-52.e7. 2009
    ..About 70% of children with milk allergy tolerate extensively heated milk (HM) products and outgrow their allergy earlier than those who react to HM...
  70. ncbi Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis
    B Takkouche
    Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Allergy 63:857-64. 2008
    ..We sought to examine the association between exposure to furry pets and asthma and allergic rhinitis by means of a meta-analysis...
  71. ncbi Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response
    Meri K Tulic
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 113:235-41. 2004
    ..Clinical trials have documented reduced allergic response to AIC in comparison with licensed ragweed extract...
  72. pmc Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
    B N Lambrecht
    Department of Pulmonary Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Clin Invest 106:551-9. 2000
    ..These data demonstrate that DCs in the airways induce sensitization to inhaled antigen and that molecules expressed on the surface of these cells are critical for the development of Th2-dependent airway eosinophilia...
  73. ncbi A mouse model for food allergy using intraperitoneal sensitization
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Methods 41:91-8. 2007
    ..most foreign proteins are immunogenic (able to induce IgG antibody responses), relatively few are important food allergens with the capacity to provoke IgE antibody production...
  74. pmc Role of interleukin 10 in specific immunotherapy
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    J Clin Invest 102:98-106. 1998
    ..Accordingly, increased IL-10 production by SIT causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgG4-related immunity...
  75. ncbi Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    Eleanor M Ling
    Department of Allergy, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Lancet 363:608-15. 2004
    Allergic diseases are frequent and rising in prevalence, and result from activation of T-helper (Th) 2 cells by allergens. CD4+CD25+ regulatory T cells suppress T-cell activation in vitro and prevent pathological findings in animal ..
  76. ncbi Characterization and immunobiology of house dust mite allergens
    Wayne R Thomas
    Telethon Institute for Child Health Research, PO Box 855, West Perth, W A 6872, Australia
    Int Arch Allergy Immunol 129:1-18. 2002
    ..There are however dominant specificities especially the group 1 and 2 allergens which can account for much of the allergenicity of extracts...
  77. pmc Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways
    You Sun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea
    J Immunol 183:5113-20. 2009
    Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming to inhaled allergens requires LPS, which is ubiquitously present in ..
  78. ncbi Mechanisms of immunotherapy to aeroallergens
    M H Shamji
    Allergy and Clinical Immunology Section, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Clin Exp Allergy 41:1235-46. 2011
    ..These insights have resulted in novel approaches and portend future biomarkers that may be surrogate or predictive of the clinical response to treatment...
  79. pmc Interleukin-17 is a negative regulator of established allergic asthma
    Silvia Schnyder-Candrian
    Universite d Orleans, Centre National de la Recherche Scientifique CNRS, Molecular Immunology and Embryology, 45071 Orleans, France
    J Exp Med 203:2715-25. 2006
    ..Although it is essential during antigen sensitization to establish allergic asthma, in sensitized mice IL-17 attenuates the allergic response by inhibiting DCs and chemokine synthesis...
  80. ncbi The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity
    Pierre Joseph Royer
    School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, United Kingdom
    J Immunol 185:1522-31. 2010
    ..We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human monocyte-derived ..
  81. ncbi Crystal structure of hyaluronidase, a major allergen of bee venom
    Z Markovic-Housley
    Division of Structural Biology Biozentrum University of Basel CH 4056, Basel, Switzerland
    Structure 8:1025-35. 2000
    ..On the basis of sequence similarity, mammalian enzymes and Hya are assigned to glycosidase family 56 for which no structure has been reported yet...
  82. ncbi Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B
    G W Scadding
    National Heart and Lung Institute, Imperial College London, UK
    Clin Exp Allergy 40:598-606. 2010
    ..The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT)...
  83. ncbi Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
    Barbara Bohle
    Department of Pathophysiology, Center for Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 120:707-13. 2007
    ..The immunologic mechanisms underlying sublingual immunotherapy (SLIT) are still unclear, particularly the role of regulatory T cells...
  84. ncbi Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge
    A Kanehiro
    Division of Basic Sciences, Department of Pediatrics and Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 163:173-84. 2001
    ..The use of agents that inhibit PDE4 may have an important role in the treatment of asthma in previously sensitized mice...
  85. pmc Association of pediatric asthma severity with exposure to common household dust allergens
    Janneane F Gent
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, One Church Street, 6th Floor, New Haven, CT 06510, USA
    Environ Res 109:768-74. 2009
    Reducing exposure to household dust inhalant allergens has been proposed as one strategy to reduce asthma.
  86. ncbi Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation
    Narcy G Arizmendi
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 186:3164-72. 2011
    ..We hypothesized that PAR(2) activation in the airways by natural allergens with serine proteinase activity plays an important role in allergic sensitization...
  87. ncbi Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity
    Rebecca S Gruchalla
    University of Texas Southwestern Medical Center at Dallas, 75390 8859, USA
    J Allergy Clin Immunol 115:478-85. 2005
    ..Asthma-associated morbidity is rising, especially in inner city children...
  88. ncbi Cities as harbingers of climate change: common ragweed, urbanization, and public health
    Lewis H Ziska
    Alternate Crop and Systems Laboratory, United States Department of Agriculture, Agricultural Research Service, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    J Allergy Clin Immunol 111:290-5. 2003
    ..Although controlled laboratory experiments have been conducted to demonstrate the sensitivity of allergenic pollen production to future climatic change (ie, increased CO(2) and temperature), no in situ data are available...
  89. ncbi Occupational asthma: current concepts in pathogenesis, diagnosis, and management
    Mark S Dykewicz
    Allergy and Immunology Service, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 123:519-28; quiz 529-30. 2009
    ..Preventive and management approaches are reviewed. Longitudinal studies of patients with OA continue to show that timely removal from exposure leads to the best prognosis...
  90. ncbi Noninjection routes for immunotherapy
    Giorgio Walter Canonica
    Division of Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    J Allergy Clin Immunol 111:437-48; quiz 449. 2003
    ..Although the long-lasting efficacy has been recently documented for the sublingual route, several points still need to be elucidated, including mechanisms of action, optimal dosage, cost-effectiveness, and adherence...
  91. ncbi Tropomyosin: an invertebrate pan-allergen
    G Reese
    Section of Allergy and Clinical Immunology, Tulane University School of Medicine, New Orleans, LA, USA
    Int Arch Allergy Immunol 119:247-58. 1999
    Among food allergens, crustaceans, such as shrimp, crab, crawfish and lobster, are a frequent cause of adverse food reactions in allergic individuals. The major allergen has been identified as the muscle protein tropomyosin...
  92. ncbi Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy
    Louisa K James
    Randall Division of Cell and Molecular Biophysics, King s College London, London, United Kingdom
    J Allergy Clin Immunol 130:663-670.e3. 2012
  93. ncbi Mechanisms of immune tolerance to allergens
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Chem Immunol Allergy 96:30-8. 2012
    In allergic diseases, immune responses are induced by normally well-tolerated allergens, which result in chronic inflammation characterized by antibody secretion and T cell activation...
  94. pmc Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice
    M Niedzwiecki
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Allergy 67:904-10. 2012
    ..fumigatus) would be associated with decreased immunoglobulin (Ig) E and airway eosinophilia and alterations in CpG methylation of T-helper genes in third-generation mice (F2)...
  95. pmc T cell homing to epithelial barriers in allergic disease
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Nat Med 18:705-15. 2012
    ..Inflammation- and tissue-specific T lymphocyte trafficking pathways are currently being targeted as new treatments for non-allergic inflammatory diseases and may yield effective new therapeutics for allergic diseases...
  96. pmc The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms
    A Konieczny
    ImmuLogic Pharmaceutical Corporation, Waltham MA 02154, USA
    Immunology 92:577-86. 1997
    Canis familiaris allergen 1 (Can f 1) and Canis familiaris allergen 2 (Can f 2) are the two major allergens present in dog dander extracts...
  97. ncbi Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy
    S Saarelainen
    Department of Clinical Microbiology, University of Kuopio, Kuopio, Finland
    Clin Exp Allergy 34:1576-82. 2004
    The use of recombinant allergens for the diagnosis and immunotherapy of allergy may offer several advantages over allergen extracts.
  98. ncbi Impacts of climate change on aeroallergens: past and future
    P J Beggs
    Department of Physical Geography, Division of Environmental and Life Sciences, Macquarie University, NSW 2109, Australia
    Clin Exp Allergy 34:1507-13. 2004
    ..It is important that public health authorities and allergy practitioners be aware of these changes in the environment, and that research scientists embrace the challenges that face further work in this area...
  99. ncbi Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures
    D Van Hemelen
    Laboratory of Allergology and Pulmonary Diseases, Dept Pathology and Medical Biology, University Medical Center of Groningen, GRIAC Research Institute, University of Groningen, The Netherlands
    J Immunol Methods 371:114-21. 2011
    ..Since this T(H) cell-population only accounts for a small percentage of T(H) cells, they are difficult to phenotype without prior selection or expansion...
  100. pmc Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6
    Iris Bellinghausen
    Department of Dermatology, University of Mainz, Mainz, Germany
    Immunology 108:167-76. 2003
    ..cells (DC) are able to induce not only T helper 1 (Th1) but also Th2 immune responses after stimulation with allergens. While DC-derived interleukin (IL)-12 and IL-18 are the key factors for the induction of Th1 cells, early ..
  101. ncbi Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative
    C G Tischer
    Helmholtz Centre Munich, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany
    Allergy 66:1570-9. 2011
    ..Several cross-sectional studies during the past 10 years have observed an increased risk of allergic outcomes for children living in damp or mouldy environments...

Research Grants78

  1. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): By crosslinking IgE bound to the high affinity IgE receptor, FceRI, allergens initiate a complex sequence of events leading to release of mast cell inflammatory mediators...
    Thomas A Platts Mills; Fiscal Year: 2010
    ..These studies have provided extensive evidence about effects of chronic exposure to indoor allergens, as well as the relevance of viruses to acute episodes in the hospital;the role of chronic sinus disease;and ..
  3. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..conclusion, by targeting IgE constant regions, PIT regimens may alleviate IgE- mediated diseases by a myriad of allergens. It is possible that PIT as a single biologics may include therapeutic indications of numerous recombinant ..
  4. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..from a well-defined cohort of human samples, with which we will explore the effect of pre-birth exposure of allergens in asthma development. The potential impact of our project is both broad and significant...
  5. Regulation/Role of AcylCer in Normal Epidermis and Atopic Dermatitis
    Peter M Elias; Fiscal Year: 2013
    ..which displays selective acylceramide (acylCer) deficiency, resulting in increased transcutaneous exposure to allergens which induce AD, and stimulate progression of AD to asthma and allergic rhinitis...
    Kwang Chul Kim; Fiscal Year: 2010
    ..cells (LDC) are also key regulators of pulmonary inflammation in response to both inhaled pathogens and allergens. DC expresses both MUC1/Muc1 and various TLRs. However, the role of MUC1/Muc1 in DC function is not known...
  7. Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    Laurence E Cheng; Fiscal Year: 2013
    ..a central role in the clinical expression of allergic disease, largely by acquiring the capacity to respond to allergens. Though the acute effects of mast cell activation by allergens are well known, the regulation of the acquisition ..
  8. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..Because several different contact allergens are known to induce IL-1[unreadable] mRNA expression by dendritic cells (DCs) in the skin, we have developed a ..
  9. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
    ..Exposure to common environmental allergens along with respiratory allergies to house dust mites, fungal spores, and cockroaches are risk factors in the ..
  10. Regulation of TSLP receptor expression and function in eczema in mice and man
    Steven F Ziegler; Fiscal Year: 2013
    ..In Aim 1, an array of molecules that bind surface receptors on DCs (allergens and toll-like receptor ligands) will be tested for their capacity to upregulate TSLPR and the relevant signaling ..
  11. Continuation of FERN Activities at the Connecticut Agricultural Experiment Statio
    LAURIE J PETERSON-WRIGHT; Fiscal Year: 2013
    ..We have used ELISA methods for surveillance samples, proficiency tests, and to determine peanut allergens in foods. We evaluated Tetracore Ricin kits and are developing techniques for Abrin analysis...
  12. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
  13. Role of Interleukin-1 in mediating epithelial-dendritic cell crosstalk in the lun
    BART N contact LAMBRECHT; Fiscal Year: 2010
    ..Recent data show that the administration of house dust mite (HDM) allergens to the airways of mice induced an increase in several DC-activating cytokines, amongst which interleukin (IL)-1[..
  14. Functional impact of IL33 polymorphisms on asthma &other Th2-mediated diseases
    Kathleen C Barnes; Fiscal Year: 2013
    ..lower airway inflammation characteristic of asthma is a Th2-mediated reaction initiated by common environmental allergens which involves the production of antigen-specific IgE antibodies...
  15. Computational and Cell Culture Models for Mucus Clearance
    Richard Superfine; Fiscal Year: 2010
    ..The particulates, pathogens and allergens are in a diffusive race for the cell membrane before they can be cleared by the entraining flow of mucus...
  16. Development and validation of a chitin assay for environmental samples
    CHRISTINE ANNE ROGERS; Fiscal Year: 2012
    ..assess chitin loads in the indoor environment since there is no assay available to do so, as there is for indoor allergens. The lack of a chitin specific assay is a critical barrier to our ability to assess the extent to which chitin ..
  17. Training in Environmental Health to Reduce Chronic Disease in Latin America
    Philip J Landrigan; Fiscal Year: 2013
    ..the most common chronic disease in children is caused or aggravated by environmental factors including indoor allergens, air pollution and tobacco smoke;2) obesity and diabetes are epidemic in developed countries and are increasing ..
  18. Nature of mamalian Cutaneous Permeablilty Barrier
    Peter M Elias; Fiscal Year: 2012
    ..role of inherited and acquired factors that could converge to degrade barrier function, allowing uptake of allergens leading to disease provocation...
  19. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills-Karp; Fiscal Year: 2013 currently thought to arise as a result of inappropriate CD4+Th2-mediated inflammatory responses to airborne allergens in susceptible individuals...
  20. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..However, the mechanisms underlying the preferential activation by environmental allergens of Th2 cells in atopic individuals still remain obscure...
  21. Chemokines and Lymphoid Tissue Organization and Function
    Jason G Cyster; Fiscal Year: 2013
    ..of improved vaccines and may suggest novel approaches for reducing unwanted responses to autoantigens or allergens. Public Health Relevance: Humoral immune responses are critical for protection against pathogens and are a cause ..
  22. Dual role of the bradykinin B2 receptor during inflammation
    Bruce L Zuraw; Fiscal Year: 2013
    ..Project Summary/Abstract Environmental exposure to viruses, noxious stimuli and allergens leads to the rapid generation of kinins in the airway...
  23. The Epidemiology of Home Allergens and Asthma
    Diane R Gold; Fiscal Year: 2010
    Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood...
  24. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..This would be predicted to result in susceptibility to pulmonary infections and hypersensitivity to inhaled allergens. Our preliminary findings indicate that induction of 15-lipoxygenase-1 may be responsible...
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..In keeping with that, the experiments proposed here take advantage of the fact that there are two allergens (alpha-gal and peanut) where sensitization appears to have become more common and which i) give rise to high ..
  26. Controlling Th2 immunity by tuning CXCL13 dependent DC migration in lymph nodes
    Frances E Lund; Fiscal Year: 2013
    ..therapeutics that can "re-direct" non-protective or pathogenic Th2 responses to parasites such as Leishmania or allergens like House Dust Mite will remain elusive...
  27. Oxidant signaling for airway remodeling and inflammation
    YUICHIRO JUSTIN SUZUKI; Fiscal Year: 2012
    ..Further, in vivo treatment of mice with allergens to induce asthma promoted degradation of annexin A1...
  28. Airway Epithelial Responses to Allergic Inflammation
    David J Erle; Fiscal Year: 2010
    ..The airway epithelium responds dramatically to cytokines produced in response to allergens and other stimuli...
  29. DC-T Cell Interactions in Pulmonary Immune Responses
    Anuradha Ray; Fiscal Year: 2012
    ..renewal application is that DC-mediated T cell differentiation in the lung-draining lymph node in response to allergens or pathogens is orchestrated by: I...
  30. Role of the Indoor Environment on Oxidative Stress Related Sinonasal Inflammation
    Murugappan Ramanathan; Fiscal Year: 2013
    ..Ramanathan seeks to better understand the impact of indoor environmental exposure (particulate matter and allergens) on oxidative stress based sinonasal inflammation regulated by the Nrf2 anti- oxidant pathway. Dr...
  31. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
    ..results from deficient Treg responses leading to inappropriate TH2 cell-mediated immune response to common allergens, and several investigators have suggested that alteration of GI mucosal barrier function may be relevant to ..
  32. Genetic Susceptibility to Nanoparticle-Induced Respiratory Disease
    ..We have also reported that CNTs increase pulmonary fibrosis in mice pre-exposed to allergens or bacterial lipopolysaccharide...
  33. Role of the Prolyl Isomerase Pin1 in the Development and Treatment of Asthma
    Kun Ping Lu; Fiscal Year: 2013
    ..induced by overexpression of proinflammatory genes that are regulated by signal pathways in response to various allergens. [For example, it has been shown that house dust mites (HDM) allergens activate TLR4 signaling in epithelial ..
  34. Immunologic Basis of Cow's Milk-Induced Hypersensitivities
    Hugh Sampson; Fiscal Year: 2013
    ..Diagnosis is definitive with the blinded food challenge, the responsible allergens [milk proteins] are well characterized including their 3-dimensional structures, and good animal models have ..
  35. Antigenic determinants of asthma-associated allergens for design of immunotherapy
    Anna Pomes; Fiscal Year: 2012
    Antigenic determinants of asthma-associated allergens for design of immunotherapy Project Summary/Abstract Allergic reactions to cockroach and dust mite are important health problems in the U.S...
  36. Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..Spdef drives mucus cell metaplasia, eosinophilic chemokine, and TH2 cytokine expression from AECs in response to allergens and rhinoviral infection...
  37. Oxidative stress in asthma initiation
    Sanjiv Sur; Fiscal Year: 2010
    ..We propose that RW (and many other pollen and mold allergens) contains POPAC, a protein complex of at least two physically associated components, the well-known antigenic ..
  38. Research Training on Chronic Lung Diseases in Southern Africa
    Thomas G Robins; Fiscal Year: 2013
    ..g., silica associated with mining &construction industries, respirable dust in coal mines, allergens and endotoxin associated with agriculture and food processing) exposures...
  39. Role of a schistosome cysteine protease in Th response polarization
    Stephen J Davies; Fiscal Year: 2013 supported by the observation that cysteine protease activity is also associated with many Th2-inducing allergens, and that cysteine proteases derived from non-helminth sources such as plants also induce Th2 responses...
  40. Role of IL-4R-alpha signaling in food allergen sensitization and anaphylaxis
    Hans C Oettgen; Fiscal Year: 2012
    ..3: To examine the effects of pharmacologic mast cell inhibition or IgE blockade on immune sensitization to food allergens and on regulation of established responses Anticipated outcome: By defining specific alterations in mechanisms ..
  41. Dual Oxidase in Airway Epithelial Injury and Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..The respiratory epithelium is critical in coordinating innate and adaptive immune responses to airborne allergens, by production of epithelial cytokines such as interleukin-33 (IL-33)...
  42. TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
    Mark E Lauer; Fiscal Year: 2013
    ..the airways that is typically accompanied by increased airway hyper-responsiveness to various stimuli, including allergens, pollutants and viruses, resulting in airway obstruction that leads to recurrent episodes of wheezing and ..
  43. Mucosal Mechanisms Linking Pulmonary and Gastrointestinal Inflammation/Immunity
    Gary B Huffnagle; Fiscal Year: 2010
    ..are being increasingly recognized to be a determining factor in the outcome of an immune response to unrelated allergens/infections...
  44. Alternaria and ribonucleases in Th2-type immunity
    Hirohito Kita; Fiscal Year: 2013
    ..We now hypothesize that the so-called "Th2-type immune response" to airborne allergens is mediated by two distinct CD4+ T cell subsets, namely Th2 cells and follicular T (Tfh) cells, which are ..
  45. Genes, Home Allergens and Asthma in Puerto Rican Children
    JUAN CARLOS CELEDON; Fiscal Year: 2010
    ..bronchodilator response) and atopy phenotypes (serum total and allergen-specific IgE, skin test reactivity to allergens, and peripheral blood eosinophil count) separately in cases and in controls, and c) asthma severity in cases...
  46. An Evaluation of Treatment with Omalizumab to Improve the Asthmatic Response to a
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..of evidence shows that patients who develop an exacerbation with RV are allergic to one or more common inhalant allergens. When patients presenting with acute asthma are studied in an emergency department, they have evidence of ..
  47. Sensitization to Cockroach Allergen: Immune Regulation and Genetic Determinants
    Peisong Gao; Fiscal Year: 2013
    ..advances have demonstrated that members of the C-type lectin receptor (CLR) family functionally interact with allergens and are critical in controllng immune response...
  48. G-Protein Coupled Receptor Kinase-2 on IgE Signaling in Mast Cells
    Hydar Ali; Fiscal Year: 2012
    ..These diseases are caused by an overzealous Th2 immune response to allergens in which immunoglobulin E (IgE) and mast cells play critical roles...
  49. Mechanisms of airway neurogenic inflammation by asthma-inducing allergens
    Armen N Akopian; Fiscal Year: 2013
    ..Though avoiding allergens and irritants while utilizing inhaled corticosteroids may help some patients, these preventatives are still ..
  50. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..with cells of both the adaptive and innate immune systems to coordinately maximize defense against inhaled allergens and that cause and exacerbate asthma, while minimizing an over exuberant immune response that could result in ..
  51. Multiplexed Bead-based In Vitro Pediatric Allergy Test
    Mark Lim; Fiscal Year: 2013
    ..Specific identification of individual allergens can also be critical for developing treatments including new forms personalized desensitizing therapies...
  52. The Epidemiology of Home Allergens and Asthma
    Diane R Gold; Fiscal Year: 2011
    ..abstract_text> ..
  53. Effect of the PPAR Agonist Pioglitazone on Epidermal Barrier in Atopic Dermatitis
    LISA ANN BECK; Fiscal Year: 2012
    ..inflammatory disorder of the skin and is initiated by Th2-driven inflammation in response to environmental allergens. Research suggests that barrier defects enable this robust immunologic response to allergens...
  54. Genetic analysis of loci associated with naive airway hyperresponsiveness
    EMILY NONE COZZI; Fiscal Year: 2010
    ..The two main causes of asthma include environmental allergens and underlying genetic susceptibility, each of which accounts for a 50% risk of developing the disease...
  55. Integrated Genomic and Functional Studies of Tolerance Therapy for Peanut Allerg
    STEPHEN JOSEPH GALLI; Fiscal Year: 2013
    ..In the U.S., ingestion of offending food allergens is the single most common cause of anaphylaxis seen in hospital emergency departments, and it is estimated that ..
  56. Innate Mechanisms Regulating CD8+ T Cell Immunity
    ROBERT LESLIE FAIRCHILD; Fiscal Year: 2010
    ..Epicutaneous contact with haptens or contact allergens such as urushiol, the reactive agent in poison ivy, and subsequent challenge results n the development and ..
  57. Defining mechanisms for how Ndfip1 regulates T cell-mediated allergic responses
    ALLISON MARIE BEAL; Fiscal Year: 2012
    ..Thus, Tregs play a key role in the maintenance of tolerance to self-antigens as well as environmental allergens. The studies proposed here will test the hypothesis that Ndfipl regulates Treg development and/or function at ..
  58. Signaling in Airway Inflammation
    Roberto P Garofalo; Fiscal Year: 2013
    ..are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants...
  59. Role of Innate Immunity in Pathogenesis of Chlamydia Pneumonia Infection
    Moshe Arditi; Fiscal Year: 2010
    ..We also observed that UV killed or live C. pneumoniae infection sensitizes the mice for allergens and exacerbates allergen-mediated eosinophilic airway inflammation with a Th2 type response in the lung...
  60. Phase II studies of gamma tocopherol as an intervention for environmental asthma
    David B Peden; Fiscal Year: 2013
    ..LPS and O3 induces influx of neutrophils (PMNs) and eosinophils in AAs as well as augmenting response to inhaled allergens. O3 is also an oxidant, and both O3 and LPS increase radical production by airway cells, with both nutritional ..
  61. Mucosal Immune Barrier in Infection and Immunity
    Keith E Mostov; Fiscal Year: 2012
    ..The epithelial cell layer is the principal barrier to entry of infectious agents, allergens and other noxious antigens...
  62. TSLP and the Pathophysiology of Asthma
    Steven F Ziegler; Fiscal Year: 2013
    ..However, the mechanisms underlying the preferential activation by environmental allergens of Th2 cells in atopic individuals still remain obscure...
  63. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ..the offending food allergen(s), whereas SPTs remain the best available test to identify relevant food allergens. Standard of care for EE includes initial endoscopy with biopsy for obtaining esophageal tissue to determine the ..
    Thomas Platts Mills; Fiscal Year: 1999
    ..The important allergens will be purified, characterized, and cloned to derive the amino acid or nucleotide sequence, as has already been ..
    Martin Chapman; Fiscal Year: 1992 determine the primary structures and the antigenic relationships between the two major groups of dust mite allergens: the 24kd Group I allergens (der p I, Der f I, and Der m I) and the 15kd Group II allergens (Der p II and Der f ..
    Thomas Robins; Fiscal Year: 2001
    ..spirometry and methacholine challenge tests, skin prick tests (for common aeroallergens and specific seafood allergens) and skin patch testing...
  67. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
    DESCRIPTION: (provided by applicant): Indoor allergens including molds and bacterial byproducts (e.g., endotoxin) have the potential to act as protective agents versus allergens capable of sensitizing and causing allergies and asthma...
  68. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2009
    ..results from deficient Treg responses leading to inappropriate TH2 cell-mediated immune response to common allergens, and several investigators have suggested that alteration of GI mucosal barrier function may be relevant to ..
    Charles Reed; Fiscal Year: 1991
    ..There is good reason to think that continued exposure to allergens in the home or outdoors might have similar, adverse long term consequences...
  70. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..objective of research at the University of Virginia has been to understand the role of foreign antigens or allergens in causing and maintaining the chronic inflammation of asthma...
  71. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    ..idea that the storage proteins in soybeans would share enough amino acid homology with the respective peanut allergens to down regulate peanut-specific T cells, we have utilized soybean protein IT in a peanut allergic mouse model ..
  72. Rapid Test for Monitoring Dust Mite Avoidance in Homes
    Martin Chapman; Fiscal Year: 2004
    b>Allergens found in the home derived from dust mites, animal dander, cockroaches and fungi are commonly associated with the development of asthma...
  73. Socio-Cultural Influences on Allergic Sensitization
    Ginger Chew; Fiscal Year: 2006
    ..In addition, we understand that housing factors influence levels of indoor allergens, such that poor housing lends rise to cockroach and mouse allergens, and high humidity is associated with high ..
  74. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    ..Deviation of immune response to allergens from a pathogenic T helper-2 type response to T helper-1 type may provide a practical approach to modifying the ..
    Thomas Platts Mills; Fiscal Year: 2001
    The objective of these studies is to improve understanding of the role that indoor allergens play in asthma and to establish effective regimes for treating the disease by reducing exposure to allergens in homes...
    ARISTO WOJDANI; Fiscal Year: 1990
    ..Since for modification of allergens this approach has not yet been used by other investigators, in this study our major goal is to encapsulate ..
  77. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..According to this paradigm, microbial exposures inhibit the development of Th2-skewed responses to environmental allergens, putatively through the induction of Th1 and/or regulatory-type responses...
    Suzanne Teuber; Fiscal Year: 2002
    Over the last ten years, genes encoding food allergens have been cloned and sequenced but no consensus sequences or motifs associated with allergy have been determined...