antigens

Summary

Summary: Substances that are recognized by the immune system and induce an immune reaction.

Top Publications

  1. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
  2. ncbi Control of B-cell responses by Toll-like receptors
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street New Haven, Connecticut 06510, USA
    Nature 438:364-8. 2005
  3. ncbi Antibody multispecificity mediated by conformational diversity
    Leo C James
    Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2HQ, UK
    Science 299:1362-7. 2003
  4. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
  5. doi Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells
    Stefano Vavassori
    Experimental Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Nat Immunol 14:908-16. 2013
  6. ncbi Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow
    E Mezey
    Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1779-82. 2000
  7. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
  8. ncbi Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    O Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 94305-5208, USA
    Nat Immunol 2:725-31. 2001
  9. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
  10. pmc Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
    Ramon Roozendaal
    Departments of Pediatrics and Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:264-76. 2009

Research Grants

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
  4. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  5. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
  6. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
  7. Ian C Michelow; Fiscal Year: 2016
  8. Tibor T Glant; Fiscal Year: 2016
  9. James D Bryers; Fiscal Year: 2016
  10. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010

Detail Information

Publications586 found, 100 shown here

  1. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
    ..The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens...
  2. ncbi Control of B-cell responses by Toll-like receptors
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street New Haven, Connecticut 06510, USA
    Nature 438:364-8. 2005
    ..We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells...
  3. ncbi Antibody multispecificity mediated by conformational diversity
    Leo C James
    Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2HQ, UK
    Science 299:1362-7. 2003
    A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting ..
  4. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
    ..When the antigens corresponded to tumor-expressed peptides, treatment with the antibody conjugate and adjuvant could prevent ..
  5. doi Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells
    Stefano Vavassori
    Experimental Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Nat Immunol 14:908-16. 2013
    ..variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC ..
  6. ncbi Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow
    E Mezey
    Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1779-82. 2000
    ..adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons ..
  7. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
    ..resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens. In this study we demonstrate the utility of a yeast surface display approach to identify tick salivary antigens ..
  8. ncbi Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    O Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 94305-5208, USA
    Nat Immunol 2:725-31. 2001
    ..These studies show that IL-10 production by DCs is critical for the induction of tolerance, and that phenotypically mature pulmonary DCs mediate tolerance induced by respiratory exposure to antigen...
  9. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
    ..Additional insight into these and other aspects of vascular morphogenesis should be possible through use of NG2 as a mural cell marker...
  10. pmc Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
    Ramon Roozendaal
    Departments of Pediatrics and Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:264-76. 2009
    To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells, we used the approach of multiphoton intravital microscopy...
  11. ncbi Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
    Marco Frentsch
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Nat Med 11:1118-24. 2005
    The direct assessment of T helper (T(H))-cell responses specific for antigens is essential to evaluate pathogenic and protective immunity...
  12. ncbi Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases
    P A Nuttall
    Centre for Ecology and Hydrology, Oxford, UK
    Parasite Immunol 28:155-63. 2006
    ..Two sources of candidate vaccine antigens have been identified: 'exposed' antigens that are secreted in tick saliva during attachment and feeding on a host ..
  13. ncbi Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
    Eve Orlandi-Pradines
    Unité de recherche en biologie et en épidémiologie parasitaires, Institut de Medecine Tropicale du Service de Sante des Armees, Parc le Pharo, BP 46, 13998 Marseille Armees, France
    Microbes Infect 9:1454-62. 2007
    Exposure to vectors of infectious diseases has been associated with antibody responses against salivary antigens of arthropods among people living in endemic areas...
  14. pmc Vesicular release of glutamate from unmyelinated axons in white matter
    Jennifer L Ziskin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe St, WBSB 813, Baltimore, Maryland 21205, USA
    Nat Neurosci 10:321-30. 2007
    ..This activity-dependent secretion of glutamate was prevalent in the developing and mature mouse corpus callosum, indicating that axons within white matter both conduct action potentials and engage in rapid neuron-glia communication...
  15. doi Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1⁺ macrophages to CD103⁺ dendritic cells
    Elisa Mazzini
    Department of Experimental Oncology, European Institute of Oncology, I 20139 Milan, Italy
    Immunity 40:248-61. 2014
    ..Chemokine receptor CX3CR1(+) macrophages were found to take up soluble fed antigens and quickly transfer them to CD103(+) dendritic cells (DCs)...
  16. ncbi NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells
    Ariel Savina
    Institut Curie, INSERM U653, Immunité et Cancer, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    Cell 126:205-18. 2006
    To initiate adaptative cytotoxic immune responses, proteolytic peptides derived from phagocytosed antigens are presented by dendritic cells (DCs) to CD8+ T lymphocytes through a process called antigen "crosspresentation...
  17. ncbi Targeting and tracing antigens in live cells with fluorescent nanobodies
    Ulrich Rothbauer
    Ludwig Maximilians University Munich, Department of Biology II, Grosshaderner Str 2, 82152 Planegg Martinsried, Germany
    Nat Methods 3:887-9. 2006
    ..We demonstrate that chromobodies can recognize and trace antigens in different subcellular compartments throughout S phase and mitosis...
  18. ncbi Detection of species-specific antibody response of humans and mice bitten by sand flies
    I Rohousova
    Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
    Parasitology 130:493-9. 2005
    ..Our data suggest that the antibody response to sand fly saliva could be used for monitoring the exposure of humans and other hosts to sand flies and might be used as a marker of risks for Leishmania transmission in endemic areas...
  19. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
    ..These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis...
  20. pmc Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    F Sallusto
    Basel Institute for Immunology, Switzerland
    J Exp Med 179:1109-18. 1994
    ....
  21. pmc The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin
    A K Gillingham
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO Rep 1:524-9. 2000
    ..When isolated from transfected cells the C-terminal domain of AKAP450 was associated with calmodulin, suggesting that this protein could contribute to centrosome assembly...
  22. ncbi The NG2 proteoglycan: past insights and future prospects
    William B Stallcup
    The Burnham Institute, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurocytol 31:423-35. 2002
    ..This research suggests that interaction of NG2 with extracellular and intracellular ligands regulates signaling events that are important for both cell proliferation and cell migration...
  23. pmc Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
    Elen Griffith
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nat Genet 40:232-6. 2008
    ..These findings also suggest that other known microcephaly genes implicated in either DNA repair responses or centrosomal function may act in common developmental pathways determining human brain and body size...
  24. ncbi Immunobiology of dendritic cells
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Annu Rev Immunol 18:767-811. 2000
    ..Although our understanding of DC biology is still in its infancy, we are now beginning to use DC-based immunotherapy protocols to elicit immunity against cancer and infectious diseases...
  25. pmc Assembly of centrosomal proteins and microtubule organization depends on PCM-1
    Alexander Dammermann
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 159:255-66. 2002
    ....
  26. pmc CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    Sandrine Henri
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 207:189-206. 2010
    ..that the quantitatively minor CD207+ CD103+ DDC subset is endowed with the unique capability of cross-presenting antigens expressed by keratinocytes irrespective of the presence of LCs...
  27. ncbi Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands
    S Das
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA
    J Infect Dis 184:1056-64. 2001
    ..To determine the salivary gland antigens that elicit antibodies in the host, an I...
  28. ncbi Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response
    M Wykes
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 161:1313-9. 1998
    ..Taken together, these observations show that DC have an important role in the initiation of Ab synthesis by direct interaction with B cells...
  29. pmc Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein
    J G Valenzuela
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Dr, Rm. 4/126, Bethesda, MD 20892, USA
    J Exp Med 194:331-42. 2001
    ..These results indicate that DTH response against saliva provides most or all of the protective effects of this vaccine and that salivary gland proteins or their cDNAs are viable vaccine targets against leishmaniasis...
  30. ncbi CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    Edith M Janssen
    Division of Cellular Immunology and Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 421:852-6. 2003
    ..Our results demonstrate that T-cell help is 'programmed' into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen...
  31. ncbi Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
    Lelia Delamarre
    Department of Cell Biology and Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 8002, USA
    Science 307:1630-4. 2005
    Antigen-presenting cells (APCs) internalize antigens and present antigen-derived peptides to T cells...
  32. pmc Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis
    Monisha Dhiman
    Department of Microbiology and Immunology, Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e28449. 2012
    ..We conclude that ROS-induced, cardiac-oxidized antigens are targets of immune recognition by antibodies and molecular determinants for pathogenesis during Chagas disease.
  33. ncbi The tick protective antigen, 4D8, is a conserved protein involved in modulation of tick blood ingestion and reproduction
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Vaccine 24:4082-95. 2006
    ....
  34. pmc IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE
    Caroline Grönwall
    Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Clin Immunol 142:390-8. 2012
    ..of IgM natural autoantibodies (NAbs) to apoptosis-associated phosphorylcholine (PC) or malondialdehyde (MDA) antigens, with lupus-associated autoantibodies and features of disease, in 120 SLE patients...
  35. ncbi Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
    Amy Bergtold
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Immunity 23:503-14. 2005
    Dendritic cells process internalized antigens to present degradative products on MHC for TCR recognition...
  36. pmc Follicular shuttling of marginal zone B cells facilitates antigen transport
    Guy Cinamon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 9:54-62. 2008
    ..population that inhabits this compartment has been linked to the capture and follicular delivery of blood-borne antigens. However, the mechanism of this antigen transport has remained unknown...
  37. pmc SVM-based prediction of linear B-cell epitopes using Bayes Feature Extraction
    Lawrence J K Wee
    Singapore Immunology Network, Biopolis, Singapore
    BMC Genomics 11:S21. 2010
    The identification of B-cell epitopes on antigens has been a subject of intense research as the knowledge of these markers has great implications for the development of peptide-based diagnostics, therapeutics and vaccines...
  38. doi Boosting antibody responses by targeting antigens to dendritic cells
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    Trends Immunol 33:71-7. 2012
    Delivering antigens directly to dendritic cells (DCs) in situ, by injecting antigens coupled to antibodies specific for DC surface molecules, is a promising strategy for enhancing vaccine efficacy...
  39. ncbi IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking
    Jennifer H Dufour
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 168:3195-204. 2002
    ..Taken together, our data suggest a role for IP-10 in both effector T cell generation and trafficking in vivo...
  40. ncbi The expression of human blood group antigens during erythropoiesis in a cell culture system
    M J Southcott
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 93:4425-35. 1999
    ..Rh c antigen appeared before Rh D antigen, and it is suggested that this may reflect a reorganization of the developing erythroid cell membrane involving the Rh polypeptides and other components, including GPA and Band 3...
  41. pmc Intestinal villous M cells: an antigen entry site in the mucosal epithelium
    Myoung Ho Jang
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:6110-5. 2004
    ..epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system...
  42. ncbi Simultaneous visualization of multiple antigens with tyramide signal amplification using antibodies from the same species
    Zsuzsanna E Toth
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Researh, National Institutes of Health, Bethesda, MD 20892 2190, USA
    J Histochem Cytochem 55:545-54. 2007
    ..It has two major advantages over existing methods. First, by using antibodies from the same host, two or more antigens can be visualized in the same section with commercially available fluorescent dyes...
  43. pmc NG2 cells: Properties, progeny and origin
    Jacqueline Trotter
    Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany
    Brain Res Rev 63:72-82. 2010
    ..The origin, heterogeneity and function of NG2 cells as modulators of the neuronal network are important incompletely resolved questions...
  44. ncbi Increased potency of Fc-receptor-targeted antigens
    P M Guyre
    Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Cancer Immunol Immunother 45:146-8. 1997
    ..In the present report we review the literature suggesting that CD64-targeted antigens are likely to be effective in vivo, and present data demonstrating enhanced immunogenicity in CD64 transgenic ..
  45. ncbi Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics
    M B Irving
    Department of Molecular Biology and Biochemistry, Simon Fraser University, BC V5A 1S6, Burnaby, Canada
    Curr Opin Chem Biol 5:314-24. 2001
    ..antigen-fragment libraries (also known as gene-fragment libraries) have been used to identify epitopes on protein antigens. These technologies promise to make significant contributions to diagnostic and vaccine development...
  46. pmc Plant-made vaccine antigens and biopharmaceuticals
    Henry Daniell
    Department of Molecular Biology and Microbiology, University of Central Florida, College of Medicine, 336 Biomolecular Science Building, Orlando, FL 32816 2364, USA
    Trends Plant Sci 14:669-79. 2009
    ....
  47. doi Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    Leda Dimou
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Neurosci 28:10434-42. 2008
    ..Thus, our results demonstrate the continuous generation of mature, myelinating oligodendrocytes in the WM, whereas cells in the GM generated mostly postmitotic NG2(+) glia...
  48. ncbi Memory B-cell persistence is independent of persisting immunizing antigen
    M Maruyama
    Institute for Genetics, University of Cologne, Germany
    Nature 407:636-42. 2000
    ....
  49. doi MAIT cells, surveyors of a new class of antigen: development and functions
    Lionel Le Bourhis
    INSERM U932, Institut Curie, Paris 75005, France
    Curr Opin Immunol 25:174-80. 2013
    ..MAIT cells react against a newly identified class of antigens: vitamin B metabolites, which are found in most bacteria and yeasts...
  50. ncbi Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells
    Praveen Elamanchili
    Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Vaccine 22:2406-12. 2004
    ..made of poly(D,L-lactic acid-co-glycolic acid) (PLGA) copolymer were characterized for enhanced delivery of antigens to murine bone marrow derived dendritic cells (DCs) in vitro...
  51. pmc Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity
    Rahul Purwar
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e16245. 2011
    ..that normal human lung contains large numbers of T(RM) cells, and these cells are poised to respond to recall antigens previously encountered through lung mucosa...
  52. pmc Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
    Poulami Mitra
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 103:16394-9. 2006
    ..Transport of S1P by ABCC1 influenced migration of mast cells toward antigen but not degranulation. These findings have important implications for S1P functions in mast cell-mediated immune responses...
  53. pmc Prediction of conformational B-cell epitopes from 3D structures by random forests with a distance-based feature
    Wen Zhang
    School of Computer, Wuhan University, Wuhan 430072, China
    BMC Bioinformatics 12:341. 2011
    ..In Antigen-antibody interactions, the specific sites on the antigens that are directly bound by the B-cell produced antibodies are well known as B-cell epitopes...
  54. ncbi Antigens drive memory IgE responses in human allergy via the nasal mucosa
    Verena Niederberger
    Department of Otorhinolaryngology, Center for Public Health, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 142:133-44. 2007
    ..The aim of this study was to analyze the influence of nasal allergen encounter on the molecular profile and magnitude of memory IgE responses and on systemic sensitivity...
  55. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
    ..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid...
  56. pmc The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    Hua Tang
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:608-17. 2010
    ..Thus, the T(H)2 response to cysteine proteases requires DC-basophil cooperation via ROS-mediated signaling...
  57. pmc Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR
    Eynav Klechevsky
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Blood 116:1685-97. 2010
    We evaluated human CD8(+) T-cell responses generated by targeting antigens to dendritic cells (DCs) through various lectin receptors...
  58. pmc Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells
    Barbara A Sullivan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 184:141-53. 2010
    ..Therefore, we suggest that the pharmacokinetic properties of glycolipids are a major determinant of cytokine skewing, suggesting a pathway for designing therapeutic glycolipids for modulating invariant NKT cell responses...
  59. pmc Chronic bystander infections and immunity to unrelated antigens
    Erietta Stelekati
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Host Microbe 12:458-69. 2012
    ..Although these observations suggest an impact of chronic infections in modulating immunity to unrelated antigens, little is known regarding the underlying mechanisms...
  60. ncbi Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter
    A M Butt
    Division of Physiology, Guy s, King s and St Thomas School of Biomedical Sciences, King s College London, United Kingdom
    Glia 26:84-91. 1999
    ....
  61. doi Tick subolesin is an ortholog of the akirins described in insects and vertebrates
    Ruth C Galindo
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain
    Dev Comp Immunol 33:612-7. 2009
    ..These results suggest that these proteins have an important role in host-pathogen interactions...
  62. pmc CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
    Takeshi Nitta
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 106:17129-33. 2009
    ..Here, we show that the deletion of thymocytes specific for insulin-promoter-driven tissue-restricted antigens (TRAs) is significantly impaired in CCR7- or CCR7-ligand-deficient mice...
  63. doi Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation
    Guerard W Byrne
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Transplantation 91:287-92. 2011
    ..gene knockout (GTKO) pigs reduced the significance of antibody to galactose alpha 1,3-galactose (Gal) antigens but did not eliminate delayed xenograft rejection (DXR)...
  64. pmc Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination
    Irlanda Olvera-Gomez
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis MN 55414, USA
    Proc Natl Acad Sci U S A 109:2072-7. 2012
    ..Chemoenzymatic generation of CT-antigen fusion proteins led to efficient priming of the CD8 T-cell responses, paving the way for development of this immunization strategy as a therapeutic option...
  65. pmc Immune complex signatures of patients with active and inactive SLE revealed by multiplex protein binding analysis on antigen microarrays
    Krisztián Papp
    Department of Immunology, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 7:e44824. 2012
    ..Multivariate analysis was applied to identify contributions of binding data on 25 antigens to the discrimination of the study groups...
  66. doi Control of Rhipicephalus (Boophilus) microplus infestations by the combination of subolesin vaccination and tick autocidal control after subolesin gene knockdown in ticks fed on cattle
    Octavio Merino
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Autonoma de Tamaulipas, Km 5 carretera Victoria Mante, CP 87000 Ciudad Victoria, Tamaulipas, Mexico
    Vaccine 29:2248-54. 2011
    ..microplus tick infestations, alone or in combination with subolesin vaccination...
  67. pmc Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation
    Andre Boonstra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
    J Exp Med 197:101-9. 2003
    ..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops...
  68. ncbi Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells
    Jason Waithman
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 179:4535-41. 2007
    ..Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool...
  69. ncbi Bacteria and their toxins tamed for immunotherapy
    Irena Adkins
    Institute of Microbiology AS CR, v v i, Videnska 1083, CZ 142 20, Prague 4, Czech Republic
    Curr Pharm Biotechnol 13:1446-73. 2012
    ....
  70. ncbi Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL
    Thomas S Griffith
    Department of Urology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 178:2679-87. 2007
    ..Animals deficient in TRAIL were resistant to tolerance induction by apoptotic cells. Thus, the outcome of an immune response taking place in the presence of cell death can be determined by the presence of CD4+-mediated Th cell function...
  71. pmc Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma
    Kirk D C Jensen
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Immunity 29:90-100. 2008
    ..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens.
  72. doi Functional differences between M cells and enterocytes in sampling luminal antigens
    Jennelle M Kyd
    Central Queensland University, Rockhampton, Queensland 4702, Australia
    Vaccine 26:6221-4. 2008
    ..Elucidation of these signalling pathways may assist in the design of effective oral vaccines that target the gut-associated lymphoid tissue...
  73. doi Chitosan-based systems for the delivery of vaccine antigens
    H Ciğdem Arca
    Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey
    Expert Rev Vaccines 8:937-53. 2009
    ..Applications of chitosan and its derivatives will be reviewed and their proposed mechanisms in the enhancement of immune responses will be discussed...
  74. doi Salmonella enterica as a vaccine carrier
    Wael Abdel Halim Hegazy
    Abteilung Mikrobiologie, Fachbereich Biologie chemie, Universität Osnabrück Barbarastrasse 11, 49076 Osnabruck, Germany
    Future Microbiol 7:111-27. 2012
    ..to deploy regulatory circuits and protein secretion systems for efficient expression and delivery of foreign antigens by Salmonella carrier strains...
  75. pmc BEST: improved prediction of B-cell epitopes from antigen sequences
    Jianzhao Gao
    School of Mathematical Sciences and LPMC, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 7:e40104. 2012
    ..57 and 0.6, which is significantly and slightly better than the next best method we tested. We also present case studies to contrast the propensity profiles generated by BEST and several other methods...
  76. ncbi Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens
    Mohamed Badawy Abdel-Naser
    Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Parasitol Res 98:550-6. 2006
    ..of bedbug (Cimex lectularius) were assessed in comparison with mosquito (Culex pipiens) and flea (Pulex irritans) antigens in the sera of papular urticaria patients (group I), siblings without papular urticaria (group IIa), patients' ..
  77. pmc Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
    N Kerlero de Rosbo
    Neuroimmunology Laboratory, La Trobe University, Bundoora, Australia
    J Clin Invest 92:2602-8. 1993
    ..to be of importance in the course of multiple sclerosis (MS), cell-mediated autoimmune responses to other myelin antigens, in particular quantitatively minor myelin antigens, such as myelin-associated glycoprotein (MAG) and the central ..
  78. ncbi The oligodendrocyte precursor cell in health and disease
    J M Levine
    Dept of Neurobiology and Behavior, SUNY, Stony Brook, NY 11794, USA
    Trends Neurosci 24:39-47. 2001
    ..The cells produce several of the chondroitin sulphate proteoglycans that might inhibit axon regeneration...
  79. ncbi Phage versus phagemid libraries for generation of human monoclonal antibodies
    David O'Connell
    Department of Anesthesia and Pharmaceutical Chemistry, University of California, San Francisco, Rm 3C 38, San Francisco General Hospital, 1001 Potrero Ave, 94110, USA
    J Mol Biol 321:49-56. 2002
    ..This could be overcome by utilizing the scFv in a multivalent format, by affinity maturation, or by converting the library to monovalent display after the first round of selection...
  80. ncbi Two separate metalloproteinase activities are responsible for the shedding and processing of the NG2 proteoglycan in vitro
    Richard A Asher
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Mol Cell Neurosci 29:82-96. 2005
    ..Ectodomain shedding converts NG2 into a diffusible entity able to interact with the growth cone, and we suggest that this release is likely to enhance its axon growth-inhibitory activity...
  81. ncbi Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    Ulf Klein
    Institute for Cancer Genetics, Department of Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Immunol 7:773-82. 2006
    ..These results identify IRF4 as a crucial transcriptional 'switch' in the generation of functionally competent plasma cells...
  82. pmc Towards an understanding of the adjuvant action of aluminium
    Philippa Marrack
    HHMI, Integrated Department of Immunology, National Jewish Health, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Nat Rev Immunol 9:287-93. 2009
    ..We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work...
  83. doi Immunological mechanisms of contact hypersensitivity in mice
    Anne Deen Christensen
    Experimental Immunology, Department of Immunopharmacology, Måløv, Denmark
    APMIS 120:1-27. 2012
    ..Here, we have described the molecular and cellular pathways in the development of CHS and have focused on recent advances and novel knowledge in the understanding of the immunoregulatory mechanisms involved in CHS...
  84. pmc Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
    Balthasar A Heesters
    the Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Immunity 38:1164-75. 2013
    ..This would explain how antigens are protected from damage and retained over long periods of time, while remaining accessible for B cells.
  85. pmc Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 192:1213-22. 2000
    ..These data show that immature and mature DCs induce different types of T cell responses: inflammatory Th1 cells are induced by mature DCs, and IL-10-producing T cell regulatory 1-like cells by immature DCs...
  86. pmc L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes
    Elena Galkina
    Division of Cellular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Exp Med 198:1323-35. 2003
    ..These results suggest that the ability to shed L-selectin is not required for T cell recirculation and homing to PLNs. However, L-selectin shedding from antigen-activated T cells prevents reentry into PLNs...
  87. pmc Neuron-glia synapses in the brain
    Dwight E Bergles
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Brain Res Rev 63:130-7. 2010
    ..Future studies using transgenic mice in which expression of receptors can be manipulated selectively in NG2 cells have to define the functions of this enigmatic neuron-glia signaling in the normal and diseased CNS...
  88. ncbi Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo
    B C Schaefer
    National Jewish Medical and Research Center, 1400 Jackson Street, K512, Denver, Colorado 80206, USA
    Cell Immunol 214:110-22. 2001
    ..Dendritic cells undergo specific morphologic changes following interactions with antigen-specific T cells...
  89. ncbi Vesicular glutamate release from axons in white matter
    Maria Kukley
    Experimental Neurophysiology, Department of Neurosurgery, University Clinic Bonn, Germany
    Nat Neurosci 10:311-20. 2007
    ..This axonal transmitter release represents a widespread mechanism for high-fidelity, activity-dependent signaling at the axon-glia interface in white matter...
  90. pmc Computational design of antibody-affinity improvement beyond in vivo maturation
    Shaun M Lippow
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 25:1171-6. 2007
    ..These results demonstrate computational capabilities for enhancing and accelerating the development of protein reagents and therapeutics...
  91. pmc A subcortical maternal complex essential for preimplantation mouse embryogenesis
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 15:416-25. 2008
    ..However, these embryos do not progress beyond cleavage stage development and female mice are sterile. The proteins are conserved in humans, and similar maternal effect mutations may result in recurrent embryonic loss...
  92. doi NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain
    Sameh Geha
    Department of Neuropathology, Sainte Anne Hospital, Paris, France
    Brain Pathol 20:399-411. 2010
    ..These results provide evidence for a persistent gliogenesis in the human cortex and white matter that is enhanced in an epileptic environment...
  93. pmc Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus
    Jitka Hostomska
    Charles University in Prague, Faculty of Science, Department of Parasitology, Vinicna 7, 128 44 Praha 2, Czech Republic
    BMC Genomics 10:282. 2009
    ..In the present work, we focused on Phlebotomus (Adlerius) arabicus, which was recently shown to transmit Leishmania tropica, the causative agent of cutaneous leishmaniasis in Israel...
  94. pmc Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library
    Y T Chen
    Cornell University Medical College, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:6919-23. 1998
    Cancer/testis (CT) antigens-immunogenic protein antigens that are expressed in testis and a proportion of diverse human cancer types-are promising targets for cancer vaccines...
  95. ncbi The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids
    S A Porcelli
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Immunol 17:297-329. 1999
    ..Identification of naturally occurring antigens presented by CD1 has revealed the surprising finding that these are predominantly a variety of foreign lipids and ..
  96. ncbi Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci Res 69:826-36. 2002
    ....
  97. ncbi The use of allele-specific recombinant Fc gamma receptor IIIb antigens for the detection of granulocyte antibodies
    J Bux
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    Blood 93:357-62. 1999
    ..of typed panel cells, we therefore established stable mammalian cells expressing recombinant NA1, NA2, and SH antigens. We isolated mRNA from typed neutrophils and then transcribed it in cDNA...
  98. ncbi Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment
    M Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 17:221-53. 1999
    ..and tolerance by countering the profound changes in the number and types of T cells stimulated by diverse antigens. T cell apoptosis occurs in at least two major forms: antigen-driven and lymphokine withdrawal...
  99. ncbi Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
    Blood 100:2908-16. 2002
    ..Strikingly, these MZMs are in direct contact with the bloodstream and efficiently capture specific polysaccharide antigens present on the surface of encapsulated bacteria...
  100. ncbi The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens
    Michael K Maier
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Eur J Immunol 37:2214-25. 2007
    ..Therefore, CD155 may assist in an efficient humoral immune response generated within the intestinal immune system...
  101. ncbi Definition of Drosophila hemocyte subsets by cell-type specific antigens
    Eva Kurucz
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
    Acta Biol Hung 58:95-111. 2007
    We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria...

Research Grants84

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..Many have complex mechanisms to rapidly generate diversity in critical antigens. Mycobacterium tuberculosis chronically infects one third of the worlds'population and similarly must avoid ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  4. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..Some enzyme immunoassays used for routine screening may detect viral antigens or antibodies, but not the infectious agents themselves...
  5. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..Results of these analyses will contribute important new insight into the nature and assembly of membrane microdomains controlling immune cell signaling. ..
  6. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..a subgingival microbial biofilm on the tooth surface that releases bacterial lipopolysaccharide (LPS) and other antigens. In turn, LPS induces leukocyte and monocyte-mediated inflammation that causes gingival tissue destruction and ..
  7. Ian C Michelow; Fiscal Year: 2016
    ..The objective of this proposal is to identify conserved Plasmodium falciparum antigens that are uniquely recognized by IgG antibodies in venous blood obtained at delivery from mothers whose infants ..
  8. Tibor T Glant; Fiscal Year: 2016
    ....
  9. James D Bryers; Fiscal Year: 2016
    ..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
  10. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Using this approach, we predict that we will be able to correlate SIV specific mucosal immune responses with reduction of viremia and protection from disease progression in macaques infected with pathogenic viruses. ..
  11. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  12. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  13. Emilio B Gonzalez; Fiscal Year: 2014
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  14. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    B cells respond to environmental antigens by assembling signalosomes at the plasma membrane for signal transduction...
  15. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  16. Craig T Morita; Fiscal Year: 2016
    ..variety of approaches are now being tried to stimulate tumor immunity by 12 T cells using tumor-specific peptide antigens. However, since CD4 and CD8 12 T cells recognize these peptides bound to MHC molecules in an MHC-restricted ..
  17. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..From previous NIH/NIAID funding we have discovered serodiagnostic antigens for 12 NIAID priority agents (Brucella melitensis, Francisella tularensis, Burkholderia pseudomallei, Coxiella ..
  18. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..Test the hypothesis that human mast cells and basophils in vitro undergo cross-desensitization to different antigens and heterologous desensitization through FcyRI and FcyRlla...
  19. Michael Demetriou; Fiscal Year: 2014
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  20. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..The findings would shed light on the role of immune system in health and disease and may identify new therapeutic approaches for arthritis. ..
  21. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..This will be tested by comparing behavior and brain health in several mouse groups including: A( vaccinated (alone) and those treated with lovastatin plus A( vaccination. ..
  22. Mitchell Kronenberg; Fiscal Year: 2014
    ..to mount robust responses against invading pathogens, but at the same time is tolerant to self-tissues or self-antigens. The mechanisms governing immune tolerance are not clear...
  23. PAUL CAMILLE TUMEH; Fiscal Year: 2015
    ..immunity through targeting of the epidermal Langerhans cells (LCs), and 2) enabling existing vaccine antigens to be co-delivered with adjuvant by a needle-free route...
  24. Mitzi Nagarkatti; Fiscal Year: 2015
    ..is an animal model that recapitulates many features of MS in which Th1 and Th17 cells reactive against myelin antigens, cross the blood-brain barrier (BBB), enter the CNS and trigger inflammation, thereby causing demyelination and ..
  25. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..cell receptor that exerts controls on B cell immunity while playing a role in antibody production to carbohydrate antigens. We hypothesize that mutations in this receptor and its isoforms can be used to elucidate the complex functions ..
  26. DHAN V KALVAKOLANU; Fiscal Year: 2014
    ..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
  27. Xianglin Shi; Fiscal Year: 2015
    ..Present study attempts to identify cyanidin-3-glucoside, a plant-derived compound, as a mechanism-based preventive agent against UV-induced skin cancers. ..
  28. Susan L Deutscher; Fiscal Year: 2016
    ..It can be envisioned that the use of molecules that specifically target antigens on carcinomas and metastases will lead to improved cancer detection and treatment modalities...
  29. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..Recently, we have obtained evidence for an obligatory role for immune responses to lung associated self-antigens (Ags) and cross talk between immune responses to self-Ags and allo-Ags in pre-disposing for the development of ..
  30. Roy Curtiss Iii; Fiscal Year: 2016
    ..are (i) to enhance induction of mucosal and systemic antibody responses to RASV-expressed protective pneumococcal antigens (as a model antigen) by increased production and release of membrane vesicles and by altering RASV cell adherence ..
  31. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Our findings suggest that DV infected ECs contribute to viremia, viral dissemination and the presentation of DV antigens on ECs that make them targets of antibodies and immune cells...
  32. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..control of mechanisms in reproduction, molecular control of spermatogenesis and oogenesis, autoimmunity to sperm antigens;sperm maturation in the epididymis, and circadian rhythms...
  33. Yaya Wang; Fiscal Year: 2014
    ..In this grant I wil study the function of a genetic variant associated with multiple autoimmune diseases, the PTPN22 1858T variant, to examine its role in immune responses and disease pathogenesis. ..
  34. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..If this project is successful, it will prevent much human suffering, enable people to return to work more quickly, and save money. ..
  35. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..Sufficient supplies of the assay components (e.g. antibodies and antigens) will be produced under quality assured conditions...
  36. Roy Curtiss Iii; Fiscal Year: 2014
    ..inducing cross-protective immunity to enteric pathogens and of delivering genus- or species-specific protective antigens to further enhance induction of immunity to enteric pathogens...
  37. Farrah Kheradmand; Fiscal Year: 2016
    ..This is an exciting area of research that could benefit the veterans that make a large portion of the general smoking population. ..
  38. Gautam Bhave; Fiscal Year: 2016
    ..Ultimately, Dr. Bhave hopes to translate his seminal biochemical discovery into an independent line of investigation examining the role of peroxidasin in matrix remodeling and expansion in renal disease. ..
  39. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..clinical tool used for diagnosis of hematopoietic malignancies based on measuring the levels of differentiation antigens. One model for the genesis of acute myeloid leukemia (AML) is that at least two mutations are leukemogenic: 1) in ..
  40. Rafi Ahmed; Fiscal Year: 2016
    ....
  41. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  42. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ....
  43. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..S. Veteran and active military population, and because of the increasing incidence of this disease in the U.S. ..
  44. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..This information will be important since the primary goal of our genetic-based investigations is to identify susceptible groups for targeted therapeutic interventions. ..
  45. Cornelia M Weyand; Fiscal Year: 2016
    ..The studies will include vaccinating RA patients with an influenza vaccine to test whether they can build sufficient T cells to be protected from infection. ..
  46. JUSTIN RICHARD BAILEY; Fiscal Year: 2016
    ..HCV vaccine development by identifying immunogenic but fitness-constrained epitopes that might serve as vaccine antigens and also by defining genetic features of broadly nAb that should be induced by a vaccine against HCV...
  47. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses...
  48. PEARLIE K BURNETTE; Fiscal Year: 2016
    ..is not clear whether the T lymphocytes become activated locally in the bone marrow against specific bone marrow antigens, or within the peripheral lymphoid system and then home to the bone marrow...
  49. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..developing a nanoemulsion (NE) based adjuvant to enhance the immunogenicity and intranasal delivery of vaccine antigens. Nanoemulsion adjuvants are oil-in-water emulsions prepared by high speed homogenization using innocuous ..
  50. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..analyses of all proteins encoded by the Mycobacterium tuberculosis (Mtb) genome, yielding a pool of protective antigens that will immediately enter development as subunit vaccines for tuberculosis...
  51. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ....
  52. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..The outstanding research environment at UCLA, the guidance from my experienced mentors, and this award will greatly facilitate my success in reaching my goals and will open a new dimension in my professional development. ..
  53. MARCEL WUETHRICH; Fiscal Year: 2015
    ..In this proposal, we will identify the host-pathogen interactions that are the foundation of vaccine-induced resistance. The knowledge gained from this research will lead to the development of fungal vaccines and adjuvants. ..
  54. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ....
  55. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..This work has the capacity to fundamentally alter our perceptions of the biology of GVHD and offer new avenues for therapy. ..
  56. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..to enteric pathogens or downregulation (via immunoregulatory T cells and mediators like TGF[unreadable]) to food antigens and commensals...
  57. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ..defective immunoregulation, mucosal barrier integrity/repair and bacterial killing, while enteric bacterial antigens stimulate intestinal inflammation...
  58. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..systemic lupus (SLE), in which heavily mutated and class-switched (mainly IgG) autoantibodies to nuclear antigens, as secreted by large numbers of plasma cells, produce widespread tissue and organ injury...
  59. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
    ....
  60. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..This study will also test to see if there are any adverse effects of gene therapy. This may result in a treatment for patients with this severe genetic disease. ..
  61. Ameae M Walker; Fiscal Year: 2015
    ..Results may also lead to the development of procedures for safely enhancing immunity in children. ..
  62. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..The applicant is an excellent candidate for this award and has outstanding potential to combine basic science with clinical applications as an MD-PhD. ..
  63. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..
  64. EVA MARIA CARMONA PORQUERA; Fiscal Year: 2016
    ..with good immunogenic properties are essential for effective vaccine therapies especially when using recombinant antigens which are generally poorly immunogenic...
  65. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..Conventional CD4+ and CD8+ T cells of the immune system recognize specific peptide antigens bound to major histocompatibility complex (MHC) class II or MHC class I molecules, respectively...
  66. Selection and Characterization of PSMA Ligands from Phage-Displayed Libraries
    Gary Fujii; Fiscal Year: 2006
    ..It has been shown that tumors often express specific antigens, such as PSMA, that are either absent or are expressed in low amounts in normal tissue...
  67. Genetics and biosynthesis of an O antigen essential for symbiosis
    KENNETH D NOEL; Fiscal Year: 2010
    ..It also is important in other interactions with animal and plant hosts. This property is a type of carbohydrate chain on the surfaces of many bacteria. The question addressed in this work is how this chain is synthesized. ..
  68. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..The process of repertoire selection is critical to the development of effective immunity to foreign antigens, transplant rejection, antigens, transplant rejection, immunosuppression and also to the pathogenesis of ..
  69. REGULATION OF IMMUNE RESPONSE IN THE ORAL CAVITY
    Suzanne Michalek; Fiscal Year: 2003
    ..mutans antigens and mucosal adjuvants. The recombinant (r) S...
  70. IMMUNE MONITORING OF ANTIGEN SPECIFIC THERAPY
    David Hafler; Fiscal Year: 2000
    ..patients orally tolerized with myelin as myelin basic protein and proteolipid protein represent sequestered brain antigens as compared to insulin, which is present in the serum...
  71. Clinical Trial of DRibble Vaccine in NSCLC
    Walter Urba; Fiscal Year: 2009
    ..to lung cancer immunotherapy that incorporates docetaxel chemotherapy to debulk the cancer, unmask hidden antigens and provide relative lymphodepletion with possible elimination of T regulatory cells combined with a novel ..
  72. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    ..will explore the molecular pathways and genetic modifiers of central and peripheral T-cell tolerance to self-antigens. Project 1. Mechanisms of peripheral CD4 T-cell tolerance (PI: A. Abbas)...
  73. MOLECULAR CLONING OF HLA CLASS II TUMOR ANTIGENS
    Dorothee Herlyn; Fiscal Year: 2003
    Our major goal is to develop a novel technology to identify HLA class II tumor antigens using a unique cloning approach in filamentous phages which has not been applied to the cloning of class II antigens in the past...
  74. MOLECULAR CLONING OF HLA CLASS II TUMOR ANTIGENS
    Dorothee Herlyn; Fiscal Year: 2000
    Our major goal is to develop a novel technology to identify HLA class II tumor antigens using a unique cloning approach in filamentous phages which has not been applied to the cloning of class II antigens in the past...
  75. Maternal transfer of protection from allergic gastrointestinal disease
    Lynn Puddington; Fiscal Year: 2009
    ..by induction of oral tolerance as a mechanism to prevent allergic gastrointestinal disease in response to food antigens. Our preliminary data demonstrate that low dose of antigen delivered from mother to child in breast milk induces ..
  76. Dual Antigen Nanoparticle Vaccine System For Bacillus Infectious Disease
    Puthupparampil Scaria; Fiscal Year: 2009
    ..However, despite most antigens being highly hydrophilic, the vast majority of nanoparticle systems (NP) being developed for vaccines are best ..
  77. MEMBRANE RECEPTOR TRAFFICKING AND ANTIGEN PROCESSING
    Richard Mitchell; Fiscal Year: 1999
    ..While a low-density compartment plays a central role in processing certain mIg-internalized antigens in A20 cells, other antigens and other B cell lines appear to require distinct high-density organelles...