biological factors

Summary

Summary: Compounds made by living organisms that contribute to or influence a phenomenon or process. They have biological or physiological activities.

Top Publications

  1. ncbi Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease
    Leanid Luksha
    Institution of Clinical Science, Technology and Intervention CLINTEC, Department of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Huddinge Campus, 14186 Stockholm, Sweden
    Atherosclerosis 202:330-44. 2009
  2. ncbi EDHF: bringing the concepts together
    Rudi Busse
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt, Germany
    Trends Pharmacol Sci 23:374-80. 2002
  3. pmc H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles
    Yanping Liu
    Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 108:566-73. 2011
  4. pmc Associations of leg fat accumulation with adiposity-related biological factors and risk of metabolic syndrome
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 21:824-30. 2013
  5. ncbi Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites
    Leanid Luksha
    Institution for Clinical Science, Intervention and Technology, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    Am J Physiol Regul Integr Comp Physiol 294:R510-9. 2008
  6. pmc Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery
    Ivica Grgic
    Department of Internal Medicine Nephrology, Philipps University, Marburg, Germany
    Br J Pharmacol 157:509-26. 2009
  7. ncbi Hydrogen peroxide as an endothelium-derived hyperpolarizing factor
    Hiroaki Shimokawa
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai, 980 8575, Japan
    Pflugers Arch 459:915-22. 2010
  8. ncbi Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other mis
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Mar Biotechnol (NY) 6:37-52. 2004
  9. ncbi Persistence of EDHF pathway and impairment of the nitric oxide pathway after chronic mercury chloride exposure in rats: mechanisms of endothelial dysfunction
    S Omanwar
    Indian Council of Medical Research ICMR, New Delhi, India
    Hum Exp Toxicol 30:1777-84. 2011
  10. ncbi Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery
    Hok Sum Leung
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Vascul Pharmacol 44:299-308. 2006

Detail Information

Publications236 found, 100 shown here

  1. ncbi Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease
    Leanid Luksha
    Institution of Clinical Science, Technology and Intervention CLINTEC, Department of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Huddinge Campus, 14186 Stockholm, Sweden
    Atherosclerosis 202:330-44. 2009
    ..Authors based on their own experience and data of literature propose several guidelines for future research in the field of EDHF...
  2. ncbi EDHF: bringing the concepts together
    Rudi Busse
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt, Germany
    Trends Pharmacol Sci 23:374-80. 2002
    ..Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization. The main concepts are considered in detail in this review...
  3. pmc H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles
    Yanping Liu
    Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 108:566-73. 2011
    ..However, H(2)O(2) has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to shear stress...
  4. pmc Associations of leg fat accumulation with adiposity-related biological factors and risk of metabolic syndrome
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 21:824-30. 2013
    ..To examine associations between regional fat mass (FM) distribution and cardiometabolic risk factors among ethnic minority groups, such as non-Hispanic blacks and Hispanics...
  5. ncbi Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites
    Leanid Luksha
    Institution for Clinical Science, Intervention and Technology, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    Am J Physiol Regul Integr Comp Physiol 294:R510-9. 2008
    ..We conclude that PE is associated with heterogeneous contribution of EDHF, and the mechanism behind EDHF-typed responses is mediated either by MEGJs alone or in combination with H(2)O(2) or cytochrome P-450 epoxygenase metabolites of AA...
  6. pmc Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery
    Ivica Grgic
    Department of Internal Medicine Nephrology, Philipps University, Marburg, Germany
    Br J Pharmacol 157:509-26. 2009
    ..1/KCa2.3 openers as novel types of blood pressure-lowering drugs...
  7. ncbi Hydrogen peroxide as an endothelium-derived hyperpolarizing factor
    Hiroaki Shimokawa
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai, 980 8575, Japan
    Pflugers Arch 459:915-22. 2010
    ..In this review, we summarize our current knowledge on H(2)O(2)/EDHF regarding its identification and mechanisms of synthesis and actions...
  8. ncbi Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other mis
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Mar Biotechnol (NY) 6:37-52. 2004
    ....
  9. ncbi Persistence of EDHF pathway and impairment of the nitric oxide pathway after chronic mercury chloride exposure in rats: mechanisms of endothelial dysfunction
    S Omanwar
    Indian Council of Medical Research ICMR, New Delhi, India
    Hum Exp Toxicol 30:1777-84. 2011
    ..The results imply that chronic mercury exposure selectively impairs the NO pathway as a consequence of oxidative stress, while EDHF is able to maintain endothelium-dependent relaxation at a reduced level...
  10. ncbi Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery
    Hok Sum Leung
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Vascul Pharmacol 44:299-308. 2006
    ..Thus, the eNOS-dependent H2O2 is likely to be the third mediator of acetylcholine-mediated relaxations in rat femoral arteries...
  11. ncbi A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum (Fr.) Karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice
    Bao Song Teng
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, People s Republic of China
    J Agric Food Chem 59:6492-500. 2011
    ..The toxicity of FYGL is very low. The results indicate that FYGL may serve as a drug candidate or a health-care food for diabetic therapy or protection...
  12. ncbi The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction
    Marco Mozzati
    Oral Surgery Unit, Dentistry Section, Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Biomed Mater Res A 95:741-6. 2010
    ..Furthermore, IL-1β and IL-6 induce fibroblast and keratinocyte proliferation, important events in wound healing. Postoperative pain and the swelling, measured at all experimental times, were reduced in the presence of PRGF...
  13. ncbi Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media
    Sofia Fernandez-Rodriguez
    Wales Heart Research Institute, Department of Diagnostic Radiology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 84:470-8. 2009
    ....
  14. ncbi The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Pharmacol Res 49:551-64. 2004
    ..This review will discuss the roles of these interacting signalling pathways in the mediation of the EDHF phenomenon...
  15. ncbi Altered myogenic constriction and endothelium-derived hyperpolarizing factor-mediated relaxation in small mesenteric arteries of hypertensive subtotally nephrectomized rats
    Simone Vettoretti
    Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration GUIDE, University of Groningen, The Netherlands
    J Hypertens 24:2215-23. 2006
    ..We investigated whether myogenic response and EDHF are altered in subtotally nephrectomized (sNX) rats and whether these changes are modifiable by chronic treatment with angiotensin-converting enzyme (ACE) inhibitor...
  16. ncbi Impaired EDHF-mediated vasodilation and function of endothelial Ca-activated K channels in uremic rats
    Ralf Köhler
    Department of Internal Medicine Nephrology, Philipps University, Marburg, Germany
    Kidney Int 67:2280-7. 2005
    ..Here we tested the hypothesis whether an altered function of endothelial K(Ca) and diminished EDHF-mediated vasodilation contribute to the endothelial dysfunction in the rat remnant kidney model of chronic renal failure...
  17. pmc Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide
    Ambroise Garry
    Department of Diagnostic Radiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 84:218-26. 2009
    ..Our objective was to investigate whether pro-oxidant properties of ascorbic acid (AA) and tetrahydrobiopterin (BH(4)) modulate endothelium-dependent, electrotonically mediated arterial relaxation...
  18. ncbi Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans
    Hiroaki Shimokawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 39:725-32. 2005
    ..In this review, we summarize our knowledge on H(2)O(2)/EDHF regarding its identification, mechanisms of synthesis, and clinical implications...
  19. ncbi Biological factors influencing parathyroid localization
    F Pons
    Department of Nuclear Medicine and Renal Transplant Unit, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Nucl Med Commun 24:121-4. 2003
    ..In parathyroid glands with no P-glycoprotein or MDR-related protein expression, the radiotracers remain in the cells, making it easier to detect them by scintigraphy...
  20. ncbi Biological factors in the pathogenesis of rotator cuff tears
    Nicola Maffulli
    Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, Mile End Hospital, London E1 4DG, England
    Sports Med Arthrosc 19:194-201. 2011
    ..Little information is available from a cellular and molecular point of view. We reviewed the biological factors involved in the pathogenesis of rotator cuff tears...
  21. ncbi Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s)
    J J McGuire
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, AB, Canada
    Can J Physiol Pharmacol 79:443-70. 2001
    ..Because endothelium-dependent vasodilatation is dysfunctional in disease states (i.e., atherosclerosis), selective vasodilators may prove to be important therapeutic agents...
  22. pmc Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice
    T Matoba
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Clin Invest 106:1521-30. 2000
    ..These results indicate that H(2)O(2) is an EDHF in mouse small mesenteric arteries and that eNOS is a major source of the reactive oxygen species...
  23. ncbi Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids
    Florian Krotz
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munchen, Germany
    Arterioscler Thromb Vasc Biol 24:595-600. 2004
    ..In many vessels, they are an endothelium-derived hyperpolarizing factor (EDHF). However, it is unknown whether they act as an EDHF on platelets and whether this has functional consequences...
  24. pmc Flow-induced enhancement of vasoconstriction and blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the rat mesentery
    A Stirrat
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Br J Pharmacol 153:1162-8. 2008
    ..We previously reported that ascorbate inhibits flow- and agonist-induced, EDHF-mediated vasodilatation in the bovine ciliary circulation. This study examined whether ascorbate had similar actions in the rat mesenteric vasculature...
  25. pmc Differential effects of ascorbate on endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and coronary artery
    Alister J McNeish
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, U K
    Br J Pharmacol 138:1172-80. 2003
    ....
  26. ncbi Ascorbate elevates perfusion pressure in the bovine extraocular long posterior ciliary artery: role of endothelium-derived hyperpolarizing factor (EDHF)
    Alison Stirrat
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Eur J Pharmacol 534:152-8. 2006
    ..5 ml(-1) and above. We conclude that ascorbate augments vasoconstrictor tone through inhibition of flow-induced EDHF activity...
  27. pmc Requirement for flow in the blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the bovine ciliary artery
    Silvia Nelli
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, G12 8QQ, Scotland
    Br J Pharmacol 142:1081-90. 2004
    ..The mechanism by which flow renders EDHF susceptible to inhibition by ascorbate remains to be determined...
  28. ncbi EDHF: new therapeutic targets?
    Michel Feletou
    Département Diabète et Maladies Métaboliques, Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Pharmacol Res 49:565-80. 2004
    ..Activating endothelial IK(Ca) and/or SK(Ca) or increasing their expression as well as improving myo-endothelial communication, for instance by increasing the expression of connexin(s), could become interesting therapeutic targets...
  29. pmc Ascorbate blocks endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and rat mesentery
    Alister J McNeish
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ
    Br J Pharmacol 135:1801-9. 2002
    ..6. In conclusion, concentrations of ascorbate present in normal plasma block EDHF-mediated vasodilator responses in the bovine eye and rat mesentery. The mechanism and physiological consequences of this blockade remain to be determined...
  30. ncbi Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization
    David H Edwards
    Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UK
    Arterioscler Thromb Vasc Biol 28:1774-81. 2008
    ..The purpose of this study was to test the hypothesis that H(2)O(2) contributes to the EDHF phenomenon by mobilizing endothelial Ca(2+) stores...
  31. ncbi Marine sponges as pharmacy
    Detmer Sipkema
    Wageningen University, Food and Bioprocess Engineering Group, 8129, 6700 EV Wageningen, The Netherlands
    Mar Biotechnol (NY) 7:142-62. 2005
    ..The fact that a particular disease can be fought at different points increases the chance of developing selective drugs for specific targets...
  32. ncbi Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9
    Jens Passauer
    Division of Nephrology, Department of Medicine, University Hospital Carl Gustav Carus, Dresden, Germany
    Kidney Int 67:1907-12. 2005
    ..We therefore determined whether one of these pathways is involved in endothelial dysfunction of uremia...
  33. ncbi Endothelium-derived hyperpolarizing factor: where are we now?
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Arterioscler Thromb Vasc Biol 26:1215-25. 2006
    ..Additionally, the endothelium can produce other factors such as lipoxygenases derivatives or hydrogen peroxide (H2O2). These different mechanisms are not necessarily exclusive and can occur simultaneously...
  34. ncbi Introduction: mild cognitive impairment--cognitive, behavioral, and biological factors
    David Salmon
    Department of Neuroscience, University of California San Diego, San Diego, California, USA
    Neurocase 11:1-2. 2005
  35. ncbi Diatom/copepod interactions in plankton: the indirect chemical defense of unicellular algae
    Georg Pohnert
    Max Planck Institut für Chemische Okologie, Hans Knoll Strasse 8, 07745 Jena, Germany
    Chembiochem 6:946-59. 2005
    ..Aspects of biosynthesis, bioassays, and the possible implications of such a chemical defense for the plankton community structure are also discussed...
  36. pmc Myoendothelial gap junction frequency does not account for sex differences in EDHF responses in rat MCA
    Elke M Sokoya
    Department of Anesthesiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Microvasc Res 74:39-44. 2007
    ..We conclude that reduced myoendothelial coupling and/or homocellular coupling within the media may account for these differences...
  37. pmc Organ culture: a new model for vascular endothelium dysfunction
    Rikard Alm
    Experimental Vascular Research, Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    BMC Cardiovasc Disord 2:8. 2002
    ..Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the suitability of organ culture as a model for endothelium dysfunction...
  38. ncbi Properties of smooth muscle hyperpolarization and relaxation to K+ in the rat isolated mesenteric artery
    K A Dora
    Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
    Am J Physiol Heart Circ Physiol 280:H2424-9. 2001
    ....
  39. ncbi Diverse mechanisms of endothelium-derived hyperpolarizing factor-mediated dilatation in small myometrial arteries in normal human pregnancy and preeclampsia
    Leanid Luksha
    Institution of Clinical Science, Technology and Intervention, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital, Huddinge Campus, Stockholm, Sweden
    Biol Reprod 83:728-35. 2010
    ..We suggest that EDHF-type responses via MEGJs are primarily targeted in small myometrial arteries in women with preeclampsia. This could significantly contribute to the impaired uteroplacental blood flow in this disorder...
  40. ncbi Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure
    Simone Gschwend
    Institut fur Klinische Pharmakologie und Toxikologie, Charité Centrum für Therapieforschung, Germany
    Life Sci 85:431-7. 2009
    ....
  41. ncbi Safety of conventional systemic agents and biologic agents in the treatment of psoriasis
    Robert Bissonnette
    Innovaderm Research, Montreal, QC
    J Cutan Med Surg 13:S67-76. 2009
    ..This article reviews the safety profiles of both classes of treatments...
  42. pmc Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery
    Andrew T Chaytor
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Pharmacol 144:108-14. 2005
    ..The findings provide further evidence that the EDHF phenomenon is electrotonic in nature, and highlight the contribution of myoendothelial and homocellular smooth muscle communication via gap junctions to arterial function...
  43. ncbi Tumour targeting: biological factors and formulation advances in injectable lipid nanoparticles
    V S Shenoy
    New Drug Delivery Systems Laboratory, Pharmacy Department, Donors Plaza, Opp University Main Office, M S University of Baroda, Fatehgunj, Vadodara 390002, India
    J Pharm Pharmacol 57:411-22. 2005
    ..Following systemic administration, numerous biological factors associated with the tumours influence the delivery of the drugs to the tumours...
  44. ncbi Drugs from hidden bugs: their discovery via untapped resources
    Fabrice Lefevre
    LibraGen, 3 rue des Satellites, Bâtiment Canal Biotech I, 31400 Toulouse, France
    Res Microbiol 159:153-61. 2008
    ..Recent technological advances in metagenomics have provided reliable access to chemicals of these hidden bugs, thus opening up new opportunities for feeding the machine...
  45. ncbi Incidence of myoendothelial gap junctions in the proximal and distal mesenteric arteries of the rat is suggestive of a role in endothelium-derived hyperpolarizing factor-mediated responses
    S L Sandow
    Autonomic Synapse Group, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, A C T, Australia
    Circ Res 86:341-6. 2000
    ..Furthermore, the relative incidence of these sites suggests that there may be a relationship between the activity of EDHF and the presence of myoendothelial gap junctions...
  46. ncbi Novel endothelium-derived relaxing factors. Identification of factors and cellular targets
    H Ding
    Department of Pharmacology and Therapeutics and The Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Pharmacol Toxicol Methods 44:441-52. 2000
    ..We describe a number of techniques that are being used to identify EDHF and present data that address the contribution of a small increase in extracellular K(+) as an EDHF...
  47. ncbi Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans
    Tetsuya Matoba
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Pharmacol Sci 92:1-6. 2003
    ..This brief review summarizes our current knowledge about H(2)O(2) as an EDHF, with special reference to its production by the endothelium, its action on membrane potentials and its pathophysiological roles...
  48. ncbi Regulation of vascular tone: the fat connection
    Maria S Fernández-Alfonso
    Hypertension 44:255-6. 2004
  49. ncbi Factors, fiction and endothelium-derived hyperpolarizing factor
    Shaun L Sandow
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Clin Exp Pharmacol Physiol 31:563-70. 2004
    ..Furthermore, in addition to the reported heterogeneity in the nature and mechanism of action of EDH(F), the contribution of experimental design and technique to this heterogeneity will be examined...
  50. ncbi Endothelium-derived hyperpolarizing factor: is there a novel chemical mediator?
    Chris R Triggle
    Smooth Muscle Research Group and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin Exp Pharmacol Physiol 29:153-60. 2002
    ..5. In this paper we review the evidence that supports and refutes the existence of a novel EDHF versus a hyperpolarization event mediated solely by myoendothelial gap junctions...
  51. ncbi The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action
    Philippe Ghisdal
    Laboratoire de Pharmacologie expérimentale Université Catholique de Louvain UCL 5410 Avenue Hippocrate, 54 B 1200 Bruxelles, Belgium
    Eur J Pharmacol 517:97-102. 2005
    ..These results indicate that the potentiation of acetylcholine-evoked responses by RHC-80267 in rat mesenteric artery is caused by the inhibition of the cholinesterase activity in the vascular wall...
  52. ncbi An ethyl acetate fraction obtained from a Southern Brazilian red wine relaxes rat mesenteric arterial bed through hyperpolarization and NO-cGMP pathway
    Elke Zuleika Schuldt
    Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Coordenadoria Especial de Farmacologia BLOCO D, Campus Universitario Trinidade Florianópolis SC, CEP 88049 900, CP 476, Brazil
    Vascul Pharmacol 43:62-8. 2005
    ..The present study demonstrates that the vasodilator effect of EAF is partially dependent upon membrane hyperpolarization in combination with nitric oxide (NO) release...
  53. ncbi Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice
    Keiko Morikawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 45:485-90. 2005
    ....
  54. ncbi [Studies on antihypertensive effect of Luobuma (Apocynum venetum L.) leaf extract (3)]
    Chie Tagawa
    Hitachizosen Corporation, Hiroshima 722 2393, Japan
    Yakugaku Zasshi 124:851-6. 2004
    ..The higher concentrations of LLE may enhance NO production/release to cause vasodilation...
  55. ncbi Captopril reverses the reduced vasodilator response to bradykinin in hypertensive pregnant rats
    A C Resende
    Department of Pharmacology, IBRAG CB State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Clin Exp Pharmacol Physiol 31:756-61. 2004
    ..Pregnancy does not modify the relative contribution of the EDHF and NO to the vasodilator effect of BK...
  56. pmc Reciprocal changes in endothelium-derived hyperpolarizing factor- and nitric oxide-system in the mesenteric artery of adult female rats following ovariectomy
    Satoshi Nawate
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Br J Pharmacol 144:178-89. 2005
    ..Increased NO result from increased activity of eNOS subsequent to a decrease in caveolin-1 and from induction of iNOS. However, excessive NO generation with elevated plasma cholesterol would raise a risk for atherosclerosis...
  57. ncbi Novel mechanism of vasodilation in inflammatory bowel disease
    Ossama A Hatoum
    Department of Medicine, Zablocki VA Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Arterioscler Thromb Vasc Biol 25:2355-61. 2005
    ..The contributions of both nitric oxide (NO) and endothelial-derived hyperpolarizing factor (EDHF) are decreased. We hypothesized that the remaining dilation results from products of cyclooxygenase...
  58. pmc Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse
    Hong Ding
    School of Medical Sciences, RMIT University, Bundoora West Campus, Bundoora, Victoria 3083, Australia
    Br J Pharmacol 146:1110-8. 2005
    ..The microvasculature of STZ-induced apoE-deficient mice developed endothelial dysfunction, which may be linked to a decrease in the contribution of the EDHF component due to a decrease in SK2 and 3 and Cx 37 expression...
  59. ncbi Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR
    Maria Alvarez de Sotomayor
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    J Vasc Res 44:354-64. 2007
    ....
  60. ncbi Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor
    Sharyn M Fitzgerald
    Department of Physiology, Monash University, Victoria 3800, Australia
    Am J Physiol Regul Integr Comp Physiol 293:R707-13. 2007
    ..Thus, prior inhibition of NOS results in endothelial dysfunction in early diabetes, since the diabetes-induced reduction in EDHF function cannot be compensated by increases in NO production...
  61. ncbi Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels
    Louise S Harrington
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, The National Heart and Lung Institute, Imperial College, London, United Kingdom
    Am J Physiol Heart Circ Physiol 293:H1682-8. 2007
    ..These data show for the first time that EDHF is released transiently, whereas endothelial-derived NO is released in a sustained manner...
  62. ncbi Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats
    Gabor Csanyi
    Department of Pathophysiology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Semmelweis 1, 6725 Szeged, Hungary
    Pharmacol Rep 59:447-55. 2007
    ..The above alterations in the endothelial function may play an important role in the development of endothelial dysfunction and vascular complications of diabetes...
  63. pmc Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice
    Marie Line Gaubert
    Integrative neuro vascular biology, UMR CNRS 6214 Inserm 771, Medical School, University of Angers, France
    J Physiol 585:617-26. 2007
    ..However, as a back-up mechanism, EDHF did not completely restore cutaneous vasodilatation, since endothelial responses were reduced in old mice compared to young adult mice...
  64. ncbi Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta
    Wachirawadee Malakul
    Department of Physiology, Faculty of Pharmacy, Mahidol University, Thailand
    Clin Exp Pharmacol Physiol 35:192-200. 2008
    ..The attenuation of NO-mediated relaxation, at least in the presence of both diabetes and hypercholesterolaemia, is associated with enhanced superoxide generation...
  65. ncbi The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta
    Ayşe Saide Sahin
    Department of Pharmacology, Meram Medicine Faculty, Selcuk University, Konya, Turkey
    Fundam Clin Pharmacol 21:595-600. 2007
    ..These results suggest that leptin relaxes the rabbit aorta. The relaxation is mediated by endothelium-derived nitric oxide and hydrogen peroxide...
  66. ncbi Effect of chronic lithium administration on endothelium-dependent relaxation of rat mesenteric bed: role of nitric oxide
    Banafsheh Afsharimani
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Can J Physiol Pharmacol 85:1038-46. 2007
    ..Simultaneous acute L-NAME and indomethacin administration suggests the possible upregulation of EDHF (endothelium-derived hyperpolarizing factor) in lithium-treated rats...
  67. ncbi Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries
    Akiko Hirao
    Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Cardiovasc Res 79:161-8. 2008
    ..Denudation and regeneration of the vascular endothelium are important in the pathogenesis of atherosclerosis. The aim of this study is to clarify the mechanisms of functional alterations in remodelled arteries following endothelial injury...
  68. ncbi In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes
    Amanda J Edgley
    Department of Physiology, Monash University, Clayton, Australia
    Am J Physiol Regul Integr Comp Physiol 295:R829-39. 2008
    ..After prior inhibition of NO synthase, EDHF mediates transient renal vasodilation in vivo. Renal endothelium-dependent vasodilation is diminished in diabetes due to impaired NO function...
  69. pmc Spreading dilatation to luminal perfusion of ATP and UTP in rat isolated small mesenteric arteries
    Polly Winter
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Physiol 582:335-47. 2007
    ....
  70. ncbi Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo
    Sharyn M Fitzgerald
    Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia
    Am J Physiol Heart Circ Physiol 293:H1072-82. 2007
    ..EDHF can fully compensate for the loss of NO, but this cannot be explained by tonic inhibition of EDHF by NO. Control of basal vasodilator tone in the mouse hindlimb is dominated by NO...
  71. ncbi Disruption of endothelial caveolae is associated with impairment of both NO- as well as EDHF in acetylcholine-induced relaxation depending on their relative contribution in different vascular beds
    Y Xu
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University of Groningen, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Life Sci 80:1678-85. 2007
    ..In contrast, in mesenteric arteries, filipin treatment only reduced EDHF formation. Disruption of endothelial caveolae is associated with the impairment of both NO and EDHF in acetylcholine-induced relaxation...
  72. ncbi Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats
    Yuri Ozawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrology (Carlton) 9:272-7. 2004
    ..The present study examined whether free radicals interacted with nitric oxide-dependent and EDHF-dependent vasodilator mechanisms in renal microvessels of salt-sensitive hypertension, using the isolated perfused hydronephrotic kidney...
  73. ncbi Augmented endothelium-derived hyperpolarizing factor-mediated relaxations attenuate endothelial dysfunction in femoral and mesenteric, but not in carotid arteries from type I diabetic rats
    Yi Shi
    Department of Pharmacology, 2 F, Laboratory Block, Faculty of Medicine Bldg 21, Sassoon Rd, Pokfulam, University of Hong Kong, Hong Kong, China
    J Pharmacol Exp Ther 318:276-81. 2006
    ..In particular, the EDHF-mediated component not only compensates for the reduced bioavailability of nitric oxide in the femoral and mesenteric artery but also counteracts the augmented endothelium-dependent contractions in the former...
  74. ncbi Vascular effects of long-term propranolol administration after chronic nitric oxide blockade
    Fernanda B M Priviero
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, P O Box 6111, 13084 971, Campinas, Sao Paulo, Brazil
    Eur J Pharmacol 571:189-96. 2007
    ..Additional mechanisms involving blockade of Ca2+ entry in the vascular smooth muscle and increase in NO bioavailability contributes to beneficial effects of long-term propranolol treatment...
  75. ncbi Effects of endothelium-derived hyperpolarizing factor and nitric oxide on endothelial function in femoral resistance arteries of spontaneously hypertensive rats
    Yoshitomo Mori
    Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Japan
    Hypertens Res 29:187-95. 2006
    ..EDHF-mediated vasodilatation was attenuated before the loss of NO-mediated vasodilatation in the femoral resistance arteries of SHR. The attenuation of this vasodilatation was mediated by the CTx plus apamin-sensitive EDHF...
  76. ncbi Vasorelaxant effect of Win 55,212-2 in rat aorta: new mechanisms involved
    M T Dannert
    Universidad Complutense de Madrid, Facultad de Medicina, Dpto Farmacologia, Avda Complutense s n 28040 Madrid, Spain
    Vascul Pharmacol 46:16-23. 2007
    ....
  77. ncbi Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
    ....
  78. pmc The oestrogen receptor beta contributes to sex related differences in endothelial function of murine small arteries via EDHF
    Leonid Luksha
    Institution for Clinical Science, Intervention and Technology CLINTEC, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    J Physiol 577:945-55. 2006
    ..The data suggest that in WT male mice, ERbeta reduces EDHF-mediated relaxation through gap junction communication...
  79. ncbi Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Açaí) extracts in mesenteric vascular bed of the rat
    A P M Rocha
    Department of Pharmacology and Psychobiology, IBRAG, UERJ, Rio de Janeiro, Brazil
    Vascul Pharmacol 46:97-104. 2007
    ..The vasodilator effect suggest a possibility to use ASE as a medicinal plant, in the treatment of cardiovascular diseases...
  80. ncbi Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats
    Masahito Kajiya
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5 1 Shikata cho, 2 chome, Okayama, 700 8558, Japan
    Am J Physiol Heart Circ Physiol 292:H2737-44. 2007
    ..Robust EDHF function will play a protective role in preserving coronary microvascular homeostasis in the event of NO dysfunction with increased superoxide levels...
  81. ncbi The role of NO-cGMP pathway and potassium channels on the relaxation induced by clonidine in the rat mesenteric arterial bed
    A M L Pimentel
    Departamento de Farmacologia e Psicobiologia, Instituto de Biologia, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Av 28 de setembro 87, Rio de Janeiro, Brazil
    Vascul Pharmacol 46:353-9. 2007
    ..Prostaglandins might participate in the vasodilator effect of clonidine when NO and EDHF mechanisms are blunted...
  82. ncbi Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries
    Xin Jin
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama, Japan
    J Pharmacol Sci 108:95-103. 2008
    ..These findings suggest that endothelium-derived hyperpolarizing factor (EDHF) via gap junctions mainly counteracts vasoconstriction induced by methoxamine in mesenteric resistance arteries...
  83. ncbi Effects of trientine, a metal chelator, on defective endothelium-dependent relaxation in the mesenteric vasculature of diabetic rats
    Melanie E Inkster
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Free Radic Res 36:1091-9. 2002
    ..Thus, the data suggest that metal catalysed ROS production makes a substantial contribution to defects in both the EDHF and NO endothelial mechanisms in diabetes, which has therapeutic implications for microvascular complications...
  84. ncbi Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery
    Xin Ma
    Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310058, China
    Life Sci 83:110-7. 2008
    ..Luteolin and apigenin protect resistance arteries from injury, implying that they may be effective in therapy for vascular diseases associated with oxidative stress...
  85. ncbi Heterogeneity of endothelium-dependent vasorelaxation in conductance and resistance arteries from Lyon normotensive and hypertensive rats
    Maria Regina Freitas
    Laboratoire de Pharmacologie et Physico Chimie des Interactions Cellulaires et Moléculaires, Universite Louis Pasteur de Strasbourg, Faculte de Pharmacie, Illkirch, France
    J Hypertens 21:1505-12. 2003
    ..Differences in endothelial function between the two strains were evaluated...
  86. ncbi Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery
    E Büssemaker
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Cardiovasc Res 59:181-8. 2003
    ..Hyperthyroidism has pronounced effects on vascular function and endothelium-dependent relaxation. The aim of the present study was to identify mechanisms underlying hyperthyroidism-induced alterations in endothelial function in rats...
  87. pmc Cellular target of voltage and calcium-dependent K(+) channel blockers involved in EDHF-mediated responses in rat superior mesenteric artery
    P Ghisdal
    Laboratoire de Pharmacologie, , UCL 5410, Avenue Hippocrate, 54 - B 1200 Bruxelles, Belgium
    Br J Pharmacol 134:1021-8. 2001
    ..The abolition of SMCs hyperpolarization to ACh by ChTX/Apa is not related to an interaction with the [Ca(2+)](endo)...
  88. ncbi Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles
    Dan Wang
    Division of Nephrology and Hypertension, Center for Renal Disease and Hypertension Research, Department of Medicine, Georgetown University, Washington, D C 20007, USA
    Kidney Int 63:2187-93. 2003
    ....
  89. pmc Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen
    Ichiro Sakuma
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Br J Pharmacol 135:48-54. 2002
    ....
  90. ncbi Acetylcholine-induced vasodilation in the uterine vascular bed of pregnant rats with adriamycin-induced nephrosis
    Mariam H Yousif
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 11:57-64. 2002
    ..This project was designed to study endothelium-dependent vasodilation in the uterine vascular bed during experimentally induced preeclampsia in rats...
  91. pmc Role for endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations in vivo
    Helena C Parkington
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    J Physiol 542:929-37. 2002
    ..However, EDHF accounts for a significant component of the conductance increase during endothelial stimulation by ACh and BK. In these beds, intermediate- and small-conductance K(Ca) channels underpin EDHF-mediated vasodilatation...
  92. ncbi Functional evidence that K+ is the non-nitric oxide, non-prostanoid endothelium-derived relaxing factor in rat femoral arteries
    Declan Savage
    Department of Human Anatomy and Physiology, University College Dublin, Ireland
    Vascul Pharmacol 40:23-8. 2003
    ..This study provides further functional evidence that EDHF is K(+) derived from endothelial cells that relaxes arterial smooth muscle subsequent to activation of Na(+)-K(+) ATPase and K(IR)...
  93. ncbi EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles
    Bernd Hoepfl
    Physiologisches Institut, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Am J Physiol Heart Circ Physiol 283:H996-H1004. 2002
    ....
  94. ncbi Role of endothelium-derived relaxing factors in adrenomedullin-induced vasodilation in the rat kidney
    Rosemary Wangensteen
    Departamento de Fisiologi a, Facultad de Medicina, Unidad de Nefrologi a Experimental, Hospital Virgen de las Nieves, E 18012, Granada, Spain
    Eur J Pharmacol 444:97-102. 2002
    ..Our data also provide evidence that prostaglandins play no role in the vasodilator response to adrenomedullin in the renal vasculature...
  95. ncbi Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors
    Luciana V Rossoni
    Department of Pharmacology and Therapeutics, Faculty of Medicine, Autonomous University of Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Am J Physiol Heart Circ Physiol 283:H2110-8. 2002
    ....
  96. ncbi Responses to endothelium-derived factors and their interaction in mesenteric arteries from Wistar-Kyoto and stroke-prone spontaneously hypertensive rats
    Fumiko Sekiguchi
    Department of Anatomy and Physiology, Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan
    Clin Exp Pharmacol Physiol 29:1066-74. 2002
    ..In addition, involvement of factors other than these three factors, which also differs between preparations from WKY rats and SHRSP, is suggested...
  97. ncbi Distinct role of nitric oxide and endothelium-derived hyperpolarizing factor in renal microcirculation. Studies in the isolated perfused hydronephrotic kidney
    Yuri Ozawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephron 92:905-13. 2002
    ..The relative contribution of these factors to the renal microvascular tone, however, has not been delineated...
  98. ncbi Endothelial G protein beta-subunits trigger nitric oxide-but not endothelium-derived hyperpolarizing factor-dependent dilation in rabbit resistance arteries
    P Véquaud
    Institut de Cardiologie de Montreal, Centre de Recherche, Montreal, Quebec, Canada
    Circ Res 89:716-22. 2001
    ..Although not directly activating the NO pathway, alpha-subunit activation is an absolute prerequisite for receptor-operated endothelium-dependent dilation of resistance arteries...
  99. pmc Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries
    C A McIntyre
    Department of Medical Sciences, Western General Hospital, University of Edinburgh, Edinburgh
    Br J Pharmacol 133:902-8. 2001
    ....
  100. ncbi Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and beta-adrenergic renal vasodilations
    Mahmoud M El-Mas
    Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
    Eur J Pharmacol 487:149-58. 2004
    ..It is concluded that the identity and relative contributions of endothelial factors to renal vasodilatory responses as well as to the inhibition of these responses by cyclosporine largely depend on the vasodilator stimulus...
  101. pmc Alterations in EDHF-mediated hyperpolarization and relaxation in mesenteric arteries of female rats in long-term deficiency of oestrogen and during oestrus cycle
    M Y Liu
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo 060-8638, Japan
    Br J Pharmacol 132:1035-46. 2001
    ....

Research Grants71

  1. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..We predict that important phenotypic variation affecting human health and disease will ultimately be traced to variation in sequence repeats of noncoding DNA in the human Y chromosome. ..
  2. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ....
  3. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..PUBLIC HEATLH RELEVANCE: Adolescent obesity develops during childhood in response to biological factors and social conditions...
  4. A Cohort Study of Preterm Delivery in Relation to Partner Abuse, Mood and Anxiety
    Michelle A Williams; Fiscal Year: 2013
    ..include individual-level behavioral and psychological factors, environmental exposures, medical conditions, biological factors, and genetics, many of which occur in combination...
  5. Prenatal Cocaine Exposure: Young Adult Follow Up
    Ruth Rose-Jacobs; Fiscal Year: 2013
    ....
  6. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..The study will be conducted in a large, prospective cohort study of endometrial cancer (GOG-0210). ..
  7. Violence Exposure, Immune Function &HIV/AIDS Risks in African American Young Ad
    FROUGH SAADATMAND; Fiscal Year: 2013
    ..Therefore, this proposal to examine behavioral and biological factors that may be related to HIV/AIDS in African American young adults is resubmitted in response to RFA-MD- 12-..
  8. IGF-II regulation of FABPs in the breast cancer survival disparity among AA women
    TELEKA CASSANDRA CALDERON; Fiscal Year: 2012
    ..is due to socioeconomic factors;however interaction of social and environmental factors can also modulate biological factors. A classic example is the protective effect that lactation has in preventing breast cancer in women...
  9. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2013
    ..disparities in health care utilization and the thrust to control costs, it is important not only to examine biological factors like type of cleft and extent of defect but {contextual factors like social class, family process}, payer ..
  10. Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence
    HILARY PATRICIA BLUMBERG; Fiscal Year: 2013
    ..Consortium core (Projects 13,14) measures of stress, biological factors and addictive behaviors will provide rich opportunities for study, including interactions between stress and ..
  11. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Despite evidence for a substantial genetic component, the inherited biological factors that promote extended life span (longevity) in humans remain unknown...
  12. Relation of Consummatory and Anticipatory Food Reward to Obesity
    Sonja Yokum; Fiscal Year: 2013
    Although twin studies imply that biological factors play a prominent role in the development of obesity, few prospective studies have identified biological factors that increase risk for future weight gain...
  13. ALCOHOL AND CELL ADHESION
    MICHAEL EDWARD CHARNESS; Fiscal Year: 2013
    ..FASD and has three broad goals: to better understand how ethanol disrupts fetal development;to identify biological factors that increase the susceptibility of women who drink during pregnancy to bear children with FASD;and to ..
  14. Young Women With Acute Myocardial Infarction
    HARLAN MARC KRUMHOLZ; Fiscal Year: 2012
    ..determine sex differences in quality of care;and 4) determine sex differences in the prevalence of selected biological factors (including sex hormones, biomarkers and genetic variations)...
  15. Sex differences in obesity and metabolic disease
    Karen Reue; Fiscal Year: 2013
    ..Thus, the FCG model offers significant advantages for discriminating among several classes of biological factors that lead to sex differences, including organizational and activational effects of gonadal hormones, and ..
  16. Estradiol, MCH and Food Intake
    Jessica C Santollo; Fiscal Year: 2010
    ..contribute to the greater prevalence of eating disorders in women, it is becoming increasing clear that biological factors may also play a key role...
  17. Prevalence and Correlates of Minor Depression in Type 2 Diabetes
    Sherita Hill Golden; Fiscal Year: 2012
    ..poor metabolic control, as is seen in MDD, and that this association might be explained by behavioral and biological factors associated with these disorders (i.e...
  18. Regulation of Type I IFNs in Tolerance and Autoimmunity
    Stefania Gallucci; Fiscal Year: 2013
    ..In addition, we will test two novel protocols of gene transfer targeting DCs that may be useful to deliver candidate genes for immune-modulation and induction of tolerance in autoimmunity and transplantation. ..
  19. Stress, Gene-Environment Interaction and Cardiovascular Disease
    Belinda L Needham; Fiscal Year: 2013
    ..This study will investigate the links between stress and biological factors important to cardiovascular disease, including the interactions between stress and genes...
  20. Sensitivity to smoking reinforcement in women: menstrual cycle effects
    Elizabeth Van Voorhees; Fiscal Year: 2012
    ..Social, cultural, and biological factors likely interact to contribute to gender differences in smoking outcomes...
  21. Mouse Model of Age-Associated Monoclonal Gammopathy
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..This project will use genetically engineered mice to dissect the mechanisms of disease susceptibility, biology and progression, performing studies that cannot be done in man, but with direct relevance to the human disease. ..
  22. Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium
    Julie R Palmer; Fiscal Year: 2013
    ..By pooling our data, specimens, and importantly, expertise to investigate these synergist hypotheses, we will elucidate much of the etiology of aggressive, early onset breast cancers in AA women. ..
  23. Regulation of Na absorption by NHE3 in the intestine
    CHANGHYON CHRIS YUN; Fiscal Year: 2013
    ..However, the molecular basis and biological factors regulating NHE3 are not fully understood...
  24. Micellar Nanocarriers with Controlled Multivalent Ligand Presentation
    Ting Xu; Fiscal Year: 2013
    ..In addition to the biological factors such as tumor physiology, the influence of a targeting moiety on the in vivo pathway and fate of ..
  25. Oxytocin regulation of social buffering following stress
    ADAM STEVEN SMITH; Fiscal Year: 2012
    ..This is particularly true when support is derived from a social partner (e.g., spouse). However, biological factors that are involved with social support and their influence on the HPA axis following a stressful event are ..
  26. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..suggests that the co-occurrence of PTSD and alcohol use disorders may arise from inherited genetic and biological factors that influence the risk for both diseases...
  27. Nicotine Dependence in Early Adulthood
    Denise B Kandel; Fiscal Year: 2010
    ..of dependence symptoms from mid adolescence to early adulthood;(2) To identify the social, psychological and biological factors, within the Developmental Socialization framework, that promote (risk factors) and those that reduce (..
  28. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew J Silva; Fiscal Year: 2013
    ..A fundamental unknown remains - what are the biological factors that cause woven bone formation after fatigue loading versus lamellar bone formation after anabolic loading? ..
  29. Explaining the SES/Overweight and Obesity Relationship
    Deborah J Bowen; Fiscal Year: 2013
    ..in middle aged Caucasian and Hispanic women, to study mechanisms including social, psychological, and biological factors, and the intersection of these factors in explaining the observed associations of obesity risk with ..
  30. The Relationship Between Osteoporosis and Phenotypic Heterogeneity in COPD
    JESSICA BON FIELD; Fiscal Year: 2013
    ..abstract_text> ..
  31. Risk and Protective Factors for Immune Health in Pediatric Cancer
    MARCIA WINTER; Fiscal Year: 2013
    ..Broad sociodemographic and life stress (e.g., SES, life events), biological factors (e.g., age at disease onset), health behaviors (e.g., sleep, diet, exercise), and psychosocial processes (e...
  32. Mouse models of age-associated monoclonal gammopathy
    PETER BERGSAGEL; Fiscal Year: 2009
    ..The results will have important implications for the prognosis, prevention and treatment of individuals with MGUS, patients with MM, and cancer patients generally. ..
  33. Rotator cuff repair using hyaluronan enriched fascia extracellular matrix
    KATHLEEN ANNE DERWIN; Fiscal Year: 2013
    ..abstract_text> ..
  34. Functional characterization of pathways regulated by schizophrenia gene TCF4
    JOSEPH LOUIE MCCLAY; Fiscal Year: 2013
    ..b>Biological factors have been strongly implicated and large-scale genome-wide association studies have now converged on several ..
  35. Genetic Influences Over Nicotine Withdrawal
    Mariella De Biasi; Fiscal Year: 2011
    ..Therefore, there is a great need for a better understanding of the behavioral and biological factors underlying nicotine withdrawal...
  36. Prognostic Markers for HIV-Postive Diffuse Large B-Cell Lymphoma
    Chun R Chao; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: This project will contribute to the understanding of tumor-related biological factors underlying the HIV- related diffuse large B-cell lymphoma aggressiveness and heterogeneity in clinical ..
  37. Novel Regulators of Glucose Homeostasis in Aging
    RADHIKA HIREN MUZUMDAR; Fiscal Year: 2013
    ..The focus of our research has been to identify biological factors that change with age and may be involved in the etiology or pathogenesis of age-related diseases...
  38. Transcription Factor NFAT1 Deficiency and Osteoarthritis
    Jinxi Wang; Fiscal Year: 2013
    ..However, key upstream biological factors that regulate the expression of these catabolic molecules remain unclear...
  39. Stress, Anxiety, and Nicotine Withdrawal
    Mariella De Biasi; Fiscal Year: 2010
    ..Therefore, there is a great need for a better understanding of the behavioral and biological factors underlying nicotine withdrawal...
  40. Predicting Radiotherapy Outcomes by Combining Physical and Biological Factors
    ISSAM MUSTAFA EL NAQA; Fiscal Year: 2010
    ..g., volume irradiated to high dose) or biological factors (e.g., inherent radiosensitivity), but not both...
  41. Rakai Adolescent Project (RAP)
    John S Santelli; Fiscal Year: 2013
    ..include social context, individual psychosocial and social developmental factors, sexual behaviors, and biological factors. We will compare the specifics of HIV risks by marital status and age of partners, by school attendance and ..
  42. Beta-Catenin and Prostate Development
    Chad M Vezina; Fiscal Year: 2013
    ..b>Biological factors regulating growth during prostate development are also believed to be responsible for inappropriate growth ..
  43. Development, Trauma, and Genotype Effects on Biomarkers of Anxiety in Children
    Tanja Jovanovic; Fiscal Year: 2013
    ..Risk factors include biological factors such as genetics as well as environmental factors, such as increased risk of child trauma exposure...
  44. Loss of fat tissue and functional responses to exercise in older, obese adults
    Barbara J Nicklas; Fiscal Year: 2013
    ..The results will also provide information on the effects of dieting during an exercise program on specific biological factors, including single muscle fiber strength, fat storage within muscle fibers, and inflammation in muscle and ..
  45. Frailty, Inflammation, and Psychological Well-being in Older Adults
    Rachel Roiland; Fiscal Year: 2011
    ..The causes of frailty are not known, but much focus has been given to understanding the biological factors associated with the condition with particular emphasis on the role of inflammation...
  46. Role of Angiogenesis and Endothelial Progenitor Cells in Diabetic Heart Failure
    Young Sup Yoon; Fiscal Year: 2010
    ..The long-term goal of this project is to define the role of the vasculature and its related biological factors in the development of diabetic HF and to establish more effective therapeutic strategies to treat diabetic ..
  47. Biomarkers of Psychological Risk and Resilience in World Trade Center Responders
    STEVEN M M SOUTHWICK; Fiscal Year: 2013
    ..125 selected from each of the four trajectories) to identify a range of exposure, psychological and biological factors that distinguis responders in the four trajectories...
  48. Alcohol Induced Chronic Pancreatitis
    Craig D Logsdon; Fiscal Year: 2013
    ..Yet, only a small percentage of those who abuse alcohol develop pancreatic disease. Clearly there are other biological factors which predispose to the development of pancreatitis and alcohol abuse is acting as a triggering mechanism...
  49. Imaging Based Dosimetry for Individualized Internal Emitter Therapy
    Yuni K Dewaraja; Fiscal Year: 2013
    ....
  50. Tools for Measuring and Analyzing Cortisol Levels in Population Studies of Health
    Ana V Diez Roux; Fiscal Year: 2010
    ..g. from community-level or neighborhood processes to biological factors) and that explicates common or interrelated processes that generate disparities in multiple health ..
  51. Transdisciplinary Training for Predoctoral Behavioral Scientists
    Melbourne F Hovell; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Behavioral factors contribute significantly to and often interact with biological factors to influence health and disease...
  52. Mechanisms of Sleepiness Symptoms in Sleep Apnea and Cardiovascular Disease
    Victoria M Pak; Fiscal Year: 2013
    ..Thus, genetic and biological factors associated with risk for sleepiness likely predict individuals who develop adverse cardiovascular outcomes...
  53. Sociodemographic, Biosocial and Behavioral Mechanisms Linked to Earlier Oral Agin
    Jung Ki Kim; Fiscal Year: 2010
    ..HEALTH RELEVANCE: It is important to understand how demographic, socioeconomic, psychological, medical and biological factors interact to produce oral health disparities across population subgroups in the United States...
  54. Aging: Insomnia Treatment and Energy Balance
    Sarosh J Motivala; Fiscal Year: 2010
    ....
  55. Brain integration of adiposity and satiety signals in the control of food intake
    Diana Williams; Fiscal Year: 2009
    ..Our studies will improve our understanding of the neural circuitry that regulates food intake and body weight, and will help identify biological factors that contribute to the development and maintenance of obesity.
  56. Understanding predictors of post-traumatic stress after pediatric medical events
    Meghan L Marsac; Fiscal Year: 2013
    ..injury period in predicting post- trauma child PTSD symptoms 2) elucidate the contribution of peri-trauma biological factors (i.e...
  57. Engineered Regeneration of Bone through a Small Molecule Cyclic Adenosine Monopho
    Cato T Laurencin; Fiscal Year: 2012
    ..Unfortunately, the use of these biological factors has shortcomings...
  58. VWF Multimer Distribution a Phenotypic Modifier of Hemophilia A
    CHAR MARIE WITMER; Fiscal Year: 2013
    ..Poncz, with an outstanding reputation in supporting the development of junior faculty into independent, NIH-funded, clinical researchers. ..
  59. Neuroimaging approaches to improve prediction of relapse during smoking cessation
    Lawrence H Sweet; Fiscal Year: 2013
    ..While biological factors, such as genetic predisposition are directly observable, other known risk factors for relapse such as ..
  60. Determinants and Consequences of Frailty among Aging HIV-infected Persons
    DAMANI PIGGOTT; Fiscal Year: 2013
    ..The epidemiologic and biological factors that determine transitions between frailty states (frailty progression and recovery) are not well-..
  61. Transmission of KSHV/HHV-8 in South Africa
    Lisa Michelle Butler; Fiscal Year: 2010
    ....
  62. Understanding Disparities in Quitting in African American and White Smokers
    Nicole L Nollen; Fiscal Year: 2013
    ..AA and White smokers treated with varenicline, 2) identify the smoking, psychosocial, treatment process, and biological factors that independently explain the relationship between race/ethnicity and cotinine-verified 7-day abstinence in ..
  63. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..Tissue engineering approach uses a biodegradable scaffold to carry biological factors and/or cells to facilitate tissue regeneration...
  64. RADON, BRONCHIAL MORPHOMETRY, AND OCCUPATIONAL HEALTH
    David Brenner; Fiscal Year: 1993
    ..factors (bronchial epithelial dose /WLM) in the two situations, but almost no attention to the relative biological factors (risk/unit bronchial dose in miners vs general public)...
  65. Fatigue After Myocardial Infarction in Older Adults
    Patricia Crane; Fiscal Year: 2005
    ..relationships of 11 variables -- age, sex, comorbidities, beta-blockers, cardiac function (heart rate, BMP), biological factors (anemia, IL-6), sleep, depression, and social support - to fatigue in older adults after Ml; and (c) explore ..
  66. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2004
    ..However, few studies have addressed genetic and other biological factors and that influence individual differences in ketamine and PCP sensitivity...
  67. JAPANESE AMERICAN COMMUNITY DIABETES STUDY
    Wilfred Fujimoto; Fiscal Year: 1990
    ..S. population, the above hypothesized relationships...
  68. CLINICAL AND PSYCHOSOCIAL INFLUENCES ON HIV THERAPY
    Richard Rothenberg; Fiscal Year: 1999
    ....
  69. BIOLOGICAL FACTORS RESPONSIBLE FOR NEUROBEHAVIORAL AGING
    CONSTANCE MEYD; Fiscal Year: 1991
    ..for age-related ani gender-related differences in the performance of cognitive and psychomotor tasks, biological factors known to alter neural function will be measured and correlated with performance...
  70. TOLERANCE TO MORPHINE ANALGESIA--BIOBEHAVIOR FACTORS
    ANTHONY VACCARINO; Fiscal Year: 1999
    ..proposal is aimed at using basic animal research to understand the relative contribution of behavioral and biological factors to analgesic tolerance in the clinical setting...
  71. DETERMINANTS OF DISABILITY IN ELDERLY MEN
    MIRJA NISSINEN; Fiscal Year: 1993
    The general aim is to analyze the long-term association of sociodemographic, behavioral and biological factors with transitions from good to morbid or disabled health status, and eventually to death...