trans activators

Summary

Summary: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

Top Publications

  1. ncbi Identification of c-MYC as a target of the APC pathway
    T C He
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 281:1509-12. 1998
  2. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  3. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  4. ncbi Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    Z Wu
    Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:115-24. 1999
  5. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
  6. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
  7. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  8. ncbi TGF-beta signal transduction
    J Massague
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 67:753-91. 1998
  9. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
  10. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002

Detail Information

Publications297 found, 100 shown here

  1. ncbi Identification of c-MYC as a target of the APC pathway
    T C He
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 281:1509-12. 1998
    ..These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers...
  2. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  3. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  4. ncbi Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    Z Wu
    Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:115-24. 1999
    ..These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function...
  5. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
    ..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology...
  6. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  7. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus...
  8. ncbi TGF-beta signal transduction
    J Massague
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 67:753-91. 1998
    ..Mutations in these pathways are the cause of various forms of human cancer and developmental disorders...
  9. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
    ..Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis...
  10. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
    ..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation...
  11. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  12. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  13. ncbi Stat3 as an oncogene
    J F Bromberg
    Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021 6399, USA
    Cell 98:295-303. 1999
    ..Thus, the activated Stat3 molecule by itself can mediate cellular transformation and the experiments focus attention on the importance of constitutive Stat3 activation in human tumors...
  14. ncbi p63 Is essential for the proliferative potential of stem cells in stratified epithelia
    Makoto Senoo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:523-36. 2007
    ..Together, these data identify p63 as a key, lineage-specific determinant of the proliferative capacity in stem cells of stratified epithelia...
  15. ncbi p63 is a p53 homologue required for limb and epidermal morphogenesis
    A A Mills
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 398:708-13. 1999
    ..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
  16. ncbi STATs and gene regulation
    J E Darnell
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA
    Science 277:1630-5. 1997
    ..The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins...
  17. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  18. ncbi Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    Yigong Shi
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Cell 113:685-700. 2003
    ..This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus...
  19. ncbi Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    R Dasgupta
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 126:4557-68. 1999
    ..Furthermore, our findings unveil the importance of activated LEF/TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place...
  20. ncbi System-level identification of transcriptional circuits underlying mammalian circadian clocks
    Hiroki R Ueda
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Nat Genet 37:187-92. 2005
    ..Our analysis further suggests that regulation of E/E' boxes is a topological vulnerability in mammalian circadian clocks, a concept that has been functionally verified using in vitro phenotype assay systems...
  21. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Thus, ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types...
  22. ncbi Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
    Joshua T Mendell
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 539 Broadway Research Building, 733 N Broadway, Baltimore, Maryland 21205, USA
    Nat Genet 36:1073-8. 2004
    ....
  23. pmc Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis
    Martin Schuster
    Department of Microbiology and W M Keck Microbial Communities and Cell Signaling Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 185:2066-79. 2003
    ..Acyl-homoserine lactone quorum sensing appears to be a system that allows ordered expression of hundreds of genes during P. aeruginosa growth in culture...
  24. ncbi STATs in oncogenesis
    T Bowman
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, FL 33612, USA
    Oncogene 19:2474-88. 2000
    ..This review presents the evidence for critical roles of STATs in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling. Oncogene (2000)...
  25. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
  26. pmc Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 425:851-6. 2003
    ..These data suggest that this pathway may have an early and critical role in the genesis of this cancer, and that maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis...
  27. ncbi XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    M Molenaar
    Department of Immunology University Hospital, Utrecht The Netherlands
    Cell 86:391-9. 1996
    ..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...
  28. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  29. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  30. pmc Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
    Isao Kashima
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Genes Dev 20:355-67. 2006
    ..Thus, the SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD...
  31. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  32. ncbi DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    S A Hahn
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 271:350-3. 1996
    ..1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers...
  33. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996
    ..p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF...
  34. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
  35. pmc p63 identifies keratinocyte stem cells
    G Pellegrini
    Laboratory of Tissue Engineering IDI, Istituto Dermopatico dell Immacolata, 00040 Rome, Italy
    Proc Natl Acad Sci U S A 98:3156-61. 2001
    ..The identification of p63 as a keratinocyte stem cell marker will be of practical importance for the clinical application of epithelial cultures in cell therapy as well as for studies on epithelial tumorigenesis...
  36. ncbi Control mechanism of the circadian clock for timing of cell division in vivo
    Takuya Matsuo
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Science 302:255-9. 2003
    ..In contrast, the circadian clockwork oscillated independently of the cell cycle in single cells. Thus, the intracellular circadian clockwork can control the cell-division cycle directly and unidirectionally in proliferating cells...
  37. ncbi CBP/p300 in cell growth, transformation, and development
    R H Goodman
    Vollum Institute, Oregon Health Sciences University, Portland 97201 USA
    Genes Dev 14:1553-77. 2000
  38. ncbi Stepwise reprogramming of B cells into macrophages
    Huafeng Xie
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine Cancer Research Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 117:663-76. 2004
    ..Our observations indicate that C/EBPalpha and beta remodel the transcription network of B cells into that of macrophages through a series of parallel and sequential changes that require endogenous PU.1...
  39. ncbi A road map for those who don't know JAK-STAT
    David S Aaronson
    Department of Pharmacology and Biological Chemistry, Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 USA
    Science 296:1653-5. 2002
    ..In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue...
  40. pmc p63 is the molecular switch for initiation of an epithelial stratification program
    Maranke I Koster
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 18:126-31. 2004
    ..Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis...
  41. ncbi De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    U Gat
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Cell 95:605-14. 1998
    ..Our findings suggest that transient beta-catenin stabilization may be a key player in the long-sought epidermal signal leading to hair development and implicate aberrant beta-catenin activation in hair tumors...
  42. ncbi Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    Z Zhong
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Science 264:95-8. 1994
    ..Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface...
  43. ncbi Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  44. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  45. ncbi Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  46. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  47. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  48. ncbi A family of cytokine-inducible inhibitors of signalling
    R Starr
    The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
    Nature 387:917-21. 1997
    ..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction...
  49. pmc Role of the TMPRSS2-ERG gene fusion in prostate cancer
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 10:177-88. 2008
    ..Our results support previous work suggesting that TMPRSS2-ERG fusions mediate invasion, consistent with the defining histologic distinction between PIN and prostate cancer...
  50. pmc p63 regulates proliferation and differentiation of developmentally mature keratinocytes
    Amy B Truong
    VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Genes Dev 20:3185-97. 2006
    ..These data indicate that p63 is required for both the proliferative and differentiation potential of developmentally mature keratinocytes...
  51. ncbi The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    H Hayashi
    Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 89:1165-73. 1997
    ..These studies thus define a novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFbeta family receptors...
  52. pmc Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    Eric E Smith
    Genome Center, Program in Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:8487-92. 2006
    ..aeruginosa strains present in advanced CF infections differ systematically from those of "wild-type" P. aeruginosa and that these differences may offer new opportunities for treatment of this chronic disease...
  53. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  54. pmc Small molecule modulation of Smoothened activity
    James K Chen
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:14071-6. 2002
    ..The mechanistic differences between the Smo antagonists may be useful in the therapeutic manipulation of Hh signaling...
  55. ncbi Activating Smoothened mutations in sporadic basal-cell carcinoma
    J Xie
    Department of Dermatology, San Francisco General Hospital, University of California, 94110, USA
    Nature 391:90-2. 1998
    ..These findings support the role of SMO as a signalling component of the SHH-receptor complex and provide direct evidence that mutated SMO can function as an oncogene in BCCs...
  56. ncbi Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  57. ncbi Bacterial interference caused by autoinducing peptide variants
    G Ji
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Science 276:2027-30. 1997
    ..Cross-inhibition of gene expression represents a type of bacterial interference that could be correlated with the ability of one strain to exclude others from infection or colonization sites, or both...
  58. ncbi Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
    P Kavsak
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Mol Cell 6:1365-75. 2000
    ..These studies thus define Smad7 as an adaptor in an E3 ubiquitin-ligase complex that targets the TGF beta receptor for degradation...
  59. pmc Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    Brett S Carver
    Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, New York, USA
    Nat Genet 41:619-24. 2009
    ..Thus, ERG has a distinct role in prostate cancer progression and cooperates with PTEN haploinsufficiency to promote progression of HGPIN to invasive adenocarcinoma...
  60. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  61. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  62. ncbi A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
    Trey K Sato
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
    Neuron 43:527-37. 2004
    ..These results suggest that opposing activities of the orphan nuclear receptors Rora and Rev-erb alpha, which represses Bmal1 expression, are important in the maintenance of circadian clock function...
  63. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  64. ncbi Stat5a is mandatory for adult mammary gland development and lactogenesis
    X Liu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, Maryland 20892 1812, USA
    Genes Dev 11:179-86. 1997
    ..These results document that Stat5a is the principal and an obligate mediator of mammopoietic and lactogenic signaling...
  65. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997
    ..Epistasis analysis positions dTCF downstream of armadillo. The Armadillo-dTCF complex mediates Wingless signaling as a bipartite transcription factor...
  66. ncbi Human Smad3 and Smad4 are sequence-specific transcription activators
    L Zawel
    Molecular Genetics Laboratory, Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Mol Cell 1:611-7. 1998
    ..These results define a novel biochemical property of Smad proteins that is likely to play a direct role in the biologic responses to TGF beta and related ligands...
  67. ncbi Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    R J Wechsler-Reya
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Neuron 22:103-14. 1999
    ..Blocking Shh function in vivo dramatically reduces GCP proliferation. These findings provide insight into the mechanisms of normal growth and tumorigenesis in the cerebellum...
  68. pmc PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    T C He
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 99:335-45. 1999
    ..These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC...
  69. ncbi Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    Ian Chambers
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland
    Cell 113:643-55. 2003
    ..These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity...
  70. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    ..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
  71. ncbi LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    B Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 411:321-5. 2001
    ..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
  72. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
    ....
  73. pmc A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
    M Kretzschmar
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021 USA
    Genes Dev 13:804-16. 1999
    ..Our results suggest a mechanism for the counterbalanced regulation of Smad2/Smad3 by TGFbeta and Ras signals in normal cells, and for the silencing of antimitogenic TGFbeta functions by hyperactive Ras in cancer cells...
  74. ncbi Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    Sunil S Karhadkar
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:707-12. 2004
    ..Monitoring and manipulating Hh pathway activity may thus offer significant improvements in diagnosis and treatment of prostate cancers with metastatic potential...
  75. pmc Global gene expression in Staphylococcus aureus biofilms
    Karen E Beenken
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    J Bacteriol 186:4665-84. 2004
    ..A primary theme that emerged from the analysis of these genes is that persistence within a biofilm requires an adaptive response that limits the deleterious effects of the reduced pH associated with anaerobic growth conditions...
  76. ncbi Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
    A Nakao
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Nature 389:631-5. 1997
    ..TGF-beta rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGF-beta responses...
  77. ncbi Synchronization of cellular clocks in the suprachiasmatic nucleus
    Shun Yamaguchi
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Science 302:1408-12. 2003
    ..Na+-dependent action potentials contributed to establishing cellular synchrony and maintaining spontaneous oscillation across the SCN...
  78. ncbi Perp is a p63-regulated gene essential for epithelial integrity
    Rebecca A Ihrie
    Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell 120:843-56. 2005
    ..These findings demonstrate that Perp is a key effector in the p63 developmental program, playing an essential role in an adhesion subprogram central to epithelial integrity and homeostasis...
  79. ncbi The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    Yoshiya Kawaguchi
    Vanderbilt Developmental Biology Program, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232 2175, USA
    Nat Genet 32:128-34. 2002
    ..These experiments provide evidence that Ptf1a expression is specifically connected to the acquisition of pancreatic fate by undifferentiated foregut endoderm...
  80. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM...
  81. ncbi The Hedgehog and Wnt signalling pathways in cancer
    J Taipale
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 411:349-54. 2001
    ..This article focuses on Hh and Wnt signal transduction and reviews evidence suggesting that tumorigenesis associated with pathway activation may result from mis-specification of cells towards stem-cell or stem cell-like fates...
  82. pmc Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    Zachary Gerhart-Hines
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    EMBO J 26:1913-23. 2007
    ..These results have implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes...
  83. pmc Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    A Hata
    Cell Biology Program, Howard Hughes Medical Institute and The Sloan Kettering Division of the Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 12:186-97. 1998
    ..Smad6 specifically competes with Smad4 for binding to receptor-activated Smad1, yielding an apparently inactive Smad1-Smad6 complex. Therefore, Smad6 selectively antagonizes BMP-activated Smad1 by acting as a Smad4 decoy...
  84. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:1645-8. 2002
    ..HCF is shown to bind to both PGC-1alpha and -1beta and augment their transcriptional activity...
  85. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
    ....
  86. pmc Target hub proteins serve as master regulators of development in yeast
    Anthony R Borneman
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA
    Genes Dev 20:435-48. 2006
    ..Our results indicate that target hubs can serve as master regulators whose activity is sufficient for the induction of complex developmental responses and therefore represent important regulatory nodes in biological networks...
  87. ncbi Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    S J Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 289:2126-8. 2000
    ..These findings suggest that the increased longevity induced by calorie restriction requires the activation of Sir2p by NAD...
  88. ncbi RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    Niels Mailand
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Cell 131:887-900. 2007
    ..These data suggest that MDC1-mediated and RNF8-executed histone ubiquitylation protects genome integrity by licensing the DSB-flanking chromatin to concentrate repair factors near the DNA lesions...
  89. pmc Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
    Jun Zhu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3129-34. 2002
    ..Together these data suggest a role for quorum sensing in modulating expression of blocks of virulence genes in a reciprocal fashion in vivo...
  90. ncbi Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 10:39-49. 1999
    ..The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10...
  91. ncbi A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    H Sasaki
    Laboratory of Developmental Biology, Osaka University, Suita, Japan
    Development 124:1313-22. 1997
    ..These results also support the idea that Gli/Ci are evolutionary conserved transcription factors in the Hedgehog signalling pathway...
  92. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  93. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
    ..Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase...
  94. ncbi Autoinduction and signal transduction in the regulation of staphylococcal virulence
    Richard P Novick
    Program in Molecular Pathogenesis, Skirball Institute, Department of Microbiology, New York University School of Medicine, 10016, USA
    Mol Microbiol 48:1429-49. 2003
    ..This review is an attempt to integrate a large body of data into the beginnings of a model that will hopefully help to guide research towards a full-scale test...
  95. ncbi Smad regulation in TGF-beta signal transduction
    A Moustakas
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    J Cell Sci 114:4359-69. 2001
    ..Finally, the inhibitory Smads (I-Smads) block phosphorylation of R-Smads by the receptors and promote ubiquitination and degradation of receptor complexes, thus inhibiting signalling...
  96. pmc Multiple small RNAs act additively to integrate sensory information and control quorum sensing in Vibrio harveyi
    Kimberly C Tu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 21:221-33. 2007
    ..Other regulators appear to be involved in control of V. harveyi qrr expression, allowing the integration of additional sensory information into the regulation of quorum-sensing gene expression...
  97. ncbi Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    Takayuki Akimoto
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:19587-93. 2005
    ..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation...
  98. ncbi Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
    Gene A Lang
    Department of Molecular Genetics, Section of Cancer Genetics, The University of Texas MD Anderson Cancer Center and The University of Texas Graduate School of Biomedical Sciences, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 119:861-72. 2004
    ..These results provide in vivo validation for the gain-of-function properties of certain p53 missense mutations and suggest a mechanistic basis for these phenotypes...
  99. pmc Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    S R McKercher
    Burnham Institute, La Jolla, CA, USA
    EMBO J 15:5647-58. 1996
    ..While the PU.1 protein appears not to be essential for myeloid and lymphoid lineage commitment, it is absolutely required for the normal differentiation of B cells and macrophages...
  100. ncbi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
    ..Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake...
  101. ncbi Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    Keith Baar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 16:1879-86. 2002
    ..These findings suggest that increases in PGC-1, NRF-1, and NRF-2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that PGC-1 mediates the coordinated increases in GLUT4 and mitochondria...

Research Grants72

  1. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ....
  2. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..abstract_text> ..
  3. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..If successful, such beneficial outcomes may improve the health of veterans with acute ischemic syndromes during cardiac transplantation, coronary bypass surgery, and other acquired cardiac conditions. ..
  4. Cell Cycle Regulation and Adult T Cell Leukemia
    Chou Zen Giam; Fiscal Year: 2013
    ..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer ..
  5. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ....
  6. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2013
    ..We will use a conditional gene knockout technology to examine the effects of hsf1 deficiency in the Her2/Neu-induced breast cancer model for tumors of epithelial origin. ..
  7. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..It is expected that the proposed mouse models will permit significant insights into the etiology, identification and treatment of these disorders. ..
  8. Regulation of HIV-1 by Rad51 in CNS cells
    Kamel Khalili; Fiscal Year: 2013
    ..The identification of novel host-viral interaction pathways can provide important information regarding the pathogenesis of AIDS/CNS disease and promote the development of more effective therapeutic strategies. ..
  9. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ....
  10. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    ..Additionally the results of these studies will shed light on the dynamics of immune cell interactions during chronic viral infections such as HTLV-1, HIV-1, hepatitis virus and herpes simplex virus. ..
  11. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    ....
  12. FEASIBILITY OF REPAIRING GBM DEFECTS IN VIVO
    Jeffrey H Miner; Fiscal Year: 2012
    ..The overall goal of this proposal is to use a mouse model system to investigate whether an abnormal GBM composition can be normalized in patients and whether this will improve and/or prolong kidney function. ..
  13. The Biosynthesis of Anandamide
    Dale G Deutsch; Fiscal Year: 2010
    ....
  14. Role of a pro-apoptotic Bcl-2 protein in the survival and death of leukemia cells
    Ameeta Kelekar; Fiscal Year: 2013
    ....
  15. Transactivation of Fetal Hemoglobin
    Kenneth R Peterson; Fiscal Year: 2011
    ....
  16. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2013
    ....
  17. Regulatory Functions of APE1 - An Essential Repair Protein
    Sankar Mitra; Fiscal Year: 2010
    ..Furthermore, our studies should help identify APE1-regulated key signaling pathways in tumor induction and promotion which could be potential targets for cancer therapy. ..
  18. Human tendon stem progenitor cell aging and regeneration
    Hui Bin Sun; Fiscal Year: 2013
    ..These findings may provide new insights into the basis for age-related tendon disorders, and the development of new strategies for tendon repair and regeneration. ..
  19. AIDS, Immune Activation and Mental Health
    Robert Dantzer; Fiscal Year: 2010
    ....
  20. Varicella-zoster Virus: Tegument Proteins in Pathogenesis
    Ann Arvin; Fiscal Year: 2012
    ..abstract_text> ..
  21. A Genetic Model of Perinatal Hippocampal Iron Deficiency
    Michael Georgieff; Fiscal Year: 2009
    ..The models will be used to determine whether the lack of iron, per se, is responsible for the cognitive deficits in humans and animal models with dietary ID without the numerous confounding variables found in dietary models. ..
  22. Targeting PCSK9 Transcription to Combat Hypercholesterolemia by Berberine
    Jingwen Liu; Fiscal Year: 2013
    ....
  23. Papillomavirus E2 Functions: Cellular Regulation and Effectors
    Peter M Howley; Fiscal Year: 2013
    ..Such compounds would be useful tools for further studies of HPV-host cell interactions and could serve as potential leads for modeling novel antivirals to treat papillomavirus infections. ..
  24. Immunological Mechanisms in Systemic Autoimmune Disease
    Ann Marshak-Rothstein; Fiscal Year: 2012
    ..This study could lead to significant insights into the factors that trigger the development of SSc and strategies that might prove useful in limiting the progression of disease in afflicted patients. ..
  25. Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization
    Jun Zhu; Fiscal Year: 2010
    ..Understanding this mechanism will have the potential to facilitate the development of effective smoking cessation programs in HIV-positive population. ..
  26. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2011
    ..This project will develop novel estrogen receptor transgenic mouse models to activate estrogen-regulated gene expression in different organs to study the diverse physiological and pathological processes controlled by estrogen. ..
  27. Activation of rapamycin-sensitive TORC1 by endomembrane amino acid transporters
    MARIA E CARDENAS-CORONA; Fiscal Year: 2013
    ..Characterization of this pathway in yeast is continuing to reveal basic aspects of TORC1 signaling that could foster analogous studies in mammals and lead to improved anticancer therapies. ..
  28. Mechanisms of Immunosuppressive Actions of Glucocorticoids
    Inez Rogatsky; Fiscal Year: 2011
    ..abstract_text> ..
  29. Effects of short-chain fatty acids on Epstein-Barr virus in B cell lymphoma
    Kelly L Gorres; Fiscal Year: 2013
    ..In addition, these mechanistic studies on SCFAs and HDAC inhibitors may help to explain the connection between diet and carcinogenesis and provide clues to how SCFAs can be applied for clinical use. ..
  30. Virus-Cell Interaction Affecting HSV Gene Expression
    Neal A DeLuca; Fiscal Year: 2013
    ..Detailed knowledge of how HSV genes are transcribed and what interactions contribute to their regulated expression may allow for strategies to block activated transcription and hence virus multiplication. ..
  31. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2011
    ..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGFalpha and acetaldehyde on the human alpha1 (I) collagen promoter will be investigated. ..
  32. hnRNP A1 inhibition of HIV-1 replication
    Massimo Caputi; Fiscal Year: 2011
    ..We propose to create to deliver this gene, or portions of it, in leukocytes, the primary target of the virus, to inhibit viral replication and block the progression of the infection. ..
  33. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..This work will shed new light on the role of chromatin in Tat-mediated HIV-1 expression. ..
  34. Context-specific Functions of CDK8
    Jun Yuan Ji; Fiscal Year: 2013
    ..The importance of this project is highlighted by the fact that dysregulation of lipid homeostasis durin development is closely linked to diseases such as diabetes, obesity, cardiovascular diseases, and certain types of cancers. ..
  35. Aging Features in Mice with Conditional Expression of p16Ink4a
    Gregory H Enders; Fiscal Year: 2013
    ..Further, this work will explore the fundamental reversibility of such aging features while defining their relationship to stem/progenitor cell arrest and senescence. ..
  36. Coordinate Regulation of p53 and c-MYC in an HTLV-1 Model of Carcinogenesis
    Robert L Harrod; Fiscal Year: 2012
    ..This R15 AREA project will provide excellent cancer research training opportunities for undergraduates and graduate students to better prepare them for future careers in the basic or clinical oncological sciences. ..
  37. Virus/host interaction in HIV neuropathogenesis
    LISA JANE HENDERSON; Fiscal Year: 2012
    ..Greater understanding of the relationship between Beta-catenin signaling and HIV infection could lead to identification of new strategies to treat HIV infection in the CNS. ..
  38. K-Rta as a Novel SUMO and Epigenetic Regulator
    Yoshihiro Izumiya; Fiscal Year: 2013
    ..abstract_text> ..
  39. Role of Cited2 in lens development and hyaloid vascular regression
    Yu Chung Yang; Fiscal Year: 2010
    ....
  40. CCCTC-binding factor (CTCF) in trinucleotide repeat instability and disease
    Albert R La Spada; Fiscal Year: 2010
    ..Finally, we will attempt to validate the function of the antisense non-coding RNA in vivo. ..
  41. Profiling and characterizing axonal precursor micro RNAs in regenerating nerve
    Soonmoon Yoo; Fiscal Year: 2013
    ..We also anticipate that these studies should identify new targets that could be manipulated to promote axonal regrowth in various neurological disorders including spinal cord injury and demyelinating neuropathies. ..
  42. MHC Class II Transactivator Function and Regulation
    JEREMY BOSS; Fiscal Year: 2009
    ..The results of these studies will ultimately identify targets for immune based therapies for the infectious disease, autoimmune disorders, and organ transplantation. ..
  43. Pathophysiological effects of cocaine/HIV-1 Tat on the medial prefrontal cortex
    Wesley N Wayman; Fiscal Year: 2013
    ..The training experiences will help assure that I complete my PhD, present and publish the work, and locate an exceptional post doctoral position in the field. ..
  44. DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
    Bernard Roizman; Fiscal Year: 2012
    ..The studies on ICPO are central to an understanding of the mechanisms by which viruses thwart fundamental mechanisms of cellular defences to infection. ..
  45. Co-evolution of HIV-1 Regulators in CNS Disease
    Brian Wigdahl; Fiscal Year: 2009
    ..This unique approach to studying regulated HIV-1 expression in the context of CNS disease and HAART will provide greater insights into HIV-1-associated pathogenesis and may lead to more efficacious treatments of HIV-1 CNS disease. ..
  46. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2012
    ....
  47. Immunoglobulin class switch DNA recombination
    Paolo Casali; Fiscal Year: 2012
    ..g., to IgG autoantibodies or atopic IgE. ..
  48. Mechanisms of Transient Transcription in Yeast
    RANDY S STRICH; Fiscal Year: 2012
    ..Aim2. Determine the role that acetylation plays in Ume6p activity and regulation. Aim3. Identify and characterize the meiotic pathways that mediate Ume6p destruction. ..
  49. Developmental role of Neuregulin-1 in subventricular zone stem cell fate
    Heather El-Amamy; Fiscal Year: 2013
    ..abstract_text> ..
  50. Genome Persistence of KSHV
    Erle S Robertson; Fiscal Year: 2013
    ....
  51. REPRESSION AND ACTIVATION OF PERSISTING HSV GENOMES
    Neal A DeLuca; Fiscal Year: 2013
    ..The completion of these studies will provide a better understanding of the repression and activation of latent genomes. ..
  52. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2009
    ..4) To develop a human xenograft model from unfolded Iobules to study early breast cancer progression for comparison with the progression models in the mouse. ..
  53. Bmal1 as a Central and Peripheral Regulator of Sleep Homeostasis
    ALLISON JOY BRAGER; Fiscal Year: 2013
    ....
  54. Fetal Postnatal Regulation of Expression of the GH Receptor
    Ram K Menon; Fiscal Year: 2010
    ..This hypothesis will be tested by analyzing the effect of podocyte- targeted deletion of the GHR gene on DM nephropathy. ..
  55. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley K Taylor; Fiscal Year: 2013
    ..Such studies are critical not only to determine whether NPY is a natural long-lasting analgesic that reduces the duration of pain, but also to harness its therapeutic potential towards the development of new analgesic drugs. ..
  56. Regulation of the MHC Class II Transactivator CIITA
    Jeremy M Boss; Fiscal Year: 2010
    ..abstract_text> ..
  57. Bioactive compound modulation of epigenetic regulator Sp1/NFkB/miR network in AML
    Shujun Liu; Fiscal Year: 2012
    ..abstract_text> ..
  58. Mitogenic Signal Transduction in Pancreatic Beta-Cells
    Christopher J Rhodes; Fiscal Year: 2013
    ..abstract_text> ..
  59. Molecular genetics of MLL-associated leukemia
    Manuel Diaz; Fiscal Year: 2009
    ..The results of these studies may allow the design of new prevention and therapeutic strategies. ..
  60. C57BI/6 Mouse Lines Expressing CRE-Recombinase in the Nervous System
    Ulrich Mueller; Fiscal Year: 2010
    ..targeting the dopamine system) and neurodegenerative disorders (e.g. targeting the limbic system and adult stem cells). ..
  61. PRODUCTION OF ALTERNATIVE FGF RECEPTOR FORMS IN TUMORS
    Gilbert J Cote; Fiscal Year: 2010
    ..A better understanding of this process may shed light on the transformation of astrocytes and provide new targets for suppressing their malignant growth. ..
  62. Plexin-A1: Regulation by CIITA and immunologic function
    Jenny P Y Ting; Fiscal Year: 2013
    ..In the new proposal, we plan to examine the role of plexins in inflammatory disorders, and to study the regulation of NLR gene transcription. ..
  63. MECHANISM OF HTLV-I TAX-MEDIATED PHOSPHORYLATION OF IKBA
    EMMETT CUNNINGHAM; Fiscal Year: 2000
    ..The candidate plans ultimately to apply the approaches and techniques learned during the five years of the training program to the study of infectious and immune-mediated eye disease. ..
  64. Effect of Cdk inhibitor on HIV-1 replication
    Fatah Kashanchi; Fiscal Year: 2007
    ..Therefore, the current proposal is aimed at determining whether drugs such as ATP analogs are a viable option in treating HIV-1 infected cells both in vitro and in vivo. [unreadable] [unreadable] [unreadable]..
  65. INHIBITING TRANSACTIVATION OF HIV-1
    Robert Ricciardi; Fiscal Year: 1992
    ..In the long term, understanding the details of both transactivation and squelching of the HIV LTR may lead to methods of gene therapy and help in the design of therapeutic agents...
  66. Modulation of c-MYC Functions in an HTLV-1 Model for Carcinogenesis
    Robert Harrod; Fiscal Year: 2009
    ..These studies may lead to the development of targeted therapeutic strategies to inhibit c-MYC oncogenic functions in hematological malignancies and solid tumors. ..
  67. MOLECULAR MECHANISM OF TAT INDUCED ANGIOGENESIS
    Cindy Morris; Fiscal Year: 2002
    ....
  68. Biological role of modifications to C/EBPbeta-1 and -2
    Linda Sealy; Fiscal Year: 2007
    ..These studies will provide important insights into how misregulated C/EBPbeta isoform expression may contribute to the development of metastatic mammary carcinoma. ..
  69. DETECTION OF VIRAL TRANSACTIVATORS IN PRIMARY CELLS
    Roger Strair; Fiscal Year: 1993
    ..The experiments proposed in the application are designed to extend these observations to other diseases and to detect and ultimately isolate as yet uncharacterized viruses which are associated with human diseases...
  70. GENETIC ANALYSIS OF MYOMETRIAL FUNCTION IN PARTURITION
    Kathleen Bethin; Fiscal Year: 2004
    ..In the future, this system will be used to study factors involved in stimulation of myometrial contraction rather than maintenance of uterine quiescence. ..
  71. GENE EXPRESSION IN XENOBIOTICS METABOLISM
    CHEN PEI TU; Fiscal Year: 1999
    ..Results from this study should enhance the overall understanding of the effects of xenobiotics in modulating mammalian and human gene activities, especially those encoding the xenobiotic metabolizing enzymes. ..
  72. PLAGL2 Expression in Emphysema Patient Lungs
    Yih Sheng Yang; Fiscal Year: 2009
    ..This research will use the LTRC collected human patient samples to establish the concept of this molecule as a novel mechanism of pathogenesis of emphysema in humans. ..