tissue inhibitor of metalloproteinase 1

Summary

Summary: A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.

Top Publications

  1. ncbi Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer
    Zheng Sheng Wu
    Department of Pathology, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Int J Cancer 122:2050-6. 2008
  2. ncbi Dynamic changes in matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 levels during wound healing in diabetic rats
    Chuan Yang
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Am Podiatr Med Assoc 99:489-96. 2009
  3. ncbi Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases
    S Lorenzl
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street Room A 501, New York, NY 10021, USA
    J Neurol Sci 207:71-6. 2003
  4. pmc Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis
    L Guedez
    National Institutes of Health, National Cancer Institute, Extracellular Matrix Section, Laboratory of Pathology, Division of Clinical Sciences, Bethesda, MD 20892, USA
    Am J Pathol 158:1207-15. 2001
  5. pmc TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis
    M L Davidsen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Ridebanevej 9, DK 1870 Frederiksberg C, Denmark
    Br J Cancer 95:1114-20. 2006
  6. ncbi Plasma and serum levels of tissue inhibitor of metalloproteinases-1 are associated with prognosis in node-negative breast cancer: a prospective study
    Sidse Ørnbjerg Würtz
    Department of Veterinary Pathology, The Faculty of Life Sciences, University of Copenhagen, Ridebanevej 9, DK 1870 Frederiksberg C, Denmark
    Mol Cell Proteomics 7:424-30. 2008
  7. ncbi Matrix metalloproteinases and oral cancer
    G T Thomas
    Department of Oral Pathology, Eastman Dental Institute for Oral Healthcare Sciences, University of London, UK
    Oral Oncol 35:227-33. 1999
  8. ncbi High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases
    A H Ree
    Departments of Tumor Biology and Pathology, The Norwegian Radium Hospital, and Hormone Laboratory, Aker Hospital, University of Oslo, Oslo, Norway
    Clin Cancer Res 3:1623-8. 1997
  9. pmc Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
    Brian C McKaig
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Pathol 162:1355-60. 2003
  10. pmc Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls
    S A Young-Min
    Department of Rheumatology, University of Newcastle upon Tyne, UK
    Ann Rheum Dis 60:846-51. 2001

Detail Information

Publications299 found, 100 shown here

  1. ncbi Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer
    Zheng Sheng Wu
    Department of Pathology, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Int J Cancer 122:2050-6. 2008
    ..Our findings suggest that MMP-9 and TIMP-1 may further be evaluated as biomarkers for predicting progression and prognosis of breast cancer...
  2. ncbi Dynamic changes in matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 levels during wound healing in diabetic rats
    Chuan Yang
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Am Podiatr Med Assoc 99:489-96. 2009
    ..caused by diabetes and measured the dynamic changes in matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) levels...
  3. ncbi Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases
    S Lorenzl
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street Room A 501, New York, NY 10021, USA
    J Neurol Sci 207:71-6. 2003
    ..These findings show that TIMPs are elevated in the CSF of patients with neurodegenerative diseases suggesting a potential role of these endogenous inhibitors of matrix metalloproteinases in neurodegenerative diseases...
  4. pmc Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis
    L Guedez
    National Institutes of Health, National Cancer Institute, Extracellular Matrix Section, Laboratory of Pathology, Division of Clinical Sciences, Bethesda, MD 20892, USA
    Am J Pathol 158:1207-15. 2001
    ..These findings suggest that TIMP-1 is an important mediator of the in vivo growth properties of EBV-positive Burkitt's lymphoma...
  5. pmc TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis
    M L Davidsen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Ridebanevej 9, DK 1870 Frederiksberg C, Denmark
    Br J Cancer 95:1114-20. 2006
    ....
  6. ncbi Plasma and serum levels of tissue inhibitor of metalloproteinases-1 are associated with prognosis in node-negative breast cancer: a prospective study
    Sidse Ørnbjerg Würtz
    Department of Veterinary Pathology, The Faculty of Life Sciences, University of Copenhagen, Ridebanevej 9, DK 1870 Frederiksberg C, Denmark
    Mol Cell Proteomics 7:424-30. 2008
    ..This was especially true in the node-negative group of patients and in patients already defined as low risk patients using the currently available prognostic parameters...
  7. ncbi Matrix metalloproteinases and oral cancer
    G T Thomas
    Department of Oral Pathology, Eastman Dental Institute for Oral Healthcare Sciences, University of London, UK
    Oral Oncol 35:227-33. 1999
    ....
  8. ncbi High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases
    A H Ree
    Departments of Tumor Biology and Pathology, The Norwegian Radium Hospital, and Hormone Laboratory, Aker Hospital, University of Oslo, Oslo, Norway
    Clin Cancer Res 3:1623-8. 1997
    ..The present data suggest that high levels of TIMP-1 and TIMP-2 mRNAs in the primary carcinomas are strongly associated with development of metastasis in breast cancer...
  9. pmc Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
    Brian C McKaig
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Pathol 162:1355-60. 2003
    ..These studies illustrate a potential mechanism by which differential expression of isoforms of TGF-beta may lead to excessive deposition of extracellular matrix and stricture formation via TIMP-1-mediated inhibition of MMP activity...
  10. pmc Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls
    S A Young-Min
    Department of Rheumatology, University of Newcastle upon Tyne, UK
    Ann Rheum Dis 60:846-51. 2001
    ..It is suggested that decreased serum levels of matrix metalloproteinases (MMPs) or increased levels of tissue inhibitors of matrix metalloproteinases (TIMPs) may account for this matrix accumulation...
  11. ncbi Pulmonary matrix metalloproteinase excess in hospital-acquired pneumonia
    Christine M Hartog
    Medizinische Klinik III and Klinik für Anaesthesiologie, Medical University of Lubeck, Lubeck, Germany
    Am J Respir Crit Care Med 167:593-8. 2003
    ..These are the first data suggesting that neutrophil-derived MMPs are increased in hospital-acquired pneumonia in association to the detection of causative microorganisms and clinical severity...
  12. pmc TIMP-2 is required for efficient activation of proMMP-2 in vivo
    Z Wang
    Roswell Park Cancer Institute, Department of Molecular and Cellular Biology, Buffalo, New York 16263, USA
    J Biol Chem 275:26411-5. 2000
    ..Mutant mice were overtly normal, viable, and fertile on the C57BL/6 background, indicating that both TIMP-2 and activated proMMP-2 are dispensable for normal development...
  13. ncbi Role of matrix metalloproteinases in inflammatory bowel disease
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Mol Aspects Med 26:379-90. 2005
    ..This review focuses on recent progress in elucidating the biological and pathological roles of MMPs in inflammatory bowel disease...
  14. pmc Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors
    Asmaa B Hamze
    College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Protein Sci 16:1905-13. 2007
    ..8 and 0.4 nM for MMP-2 and -9, respectively. Interestingly, the Gly mutant has a Ki of 2.1 nM for MMP-9 and >40 muM for MMP-2, indicating that engineered TIMPs can discriminate between MMPs in the same subfamily...
  15. ncbi Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer
    Allan Lipton
    Penn State University, Hershey Medical Center, Hematology Oncology, 500 University Dr, Hershey, PA 17033, USA
    J Clin Oncol 26:2653-8. 2008
    ..To determine the effect of elevated serum TIMP-1 on the response of patients with metastatic breast cancer to an aromatase inhibitor versus tamoxifen...
  16. ncbi Total levels of tissue inhibitor of metalloproteinases 1 in plasma yield high diagnostic sensitivity and specificity in patients with colon cancer
    Mads N Holten-Andersen
    The Finsen Laboratory, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
    Clin Cancer Res 8:156-64. 2002
    ....
  17. ncbi Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes
    Thomas Pufe
    Department of Anatomy, University of Kiel, D 24098 Kiel, Germany
    J Pathol 202:367-74. 2004
    ..These findings indicate that VEGF is an autocrine stimulator of immortalized chondrocytes that mediates mainly destructive processes in osteoarthritis...
  18. ncbi Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury
    Suzanne E G Fligiel
    Department of Pathology, The University of Michigan, Ann Arbor, 48109, USA
    Hum Pathol 37:422-30. 2006
    ..On the other hand, the presence of detectable MMP-1 and/or MMP-3 is an indicator of more ominous disease progression...
  19. pmc Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines
    C S Cleaver
    Department of Rheumatology, School of Clinical and Medical Sciences, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Ann Rheum Dis 60:150-7. 2001
    ..To investigate whether interleukin 13 (IL13) could act in a chondroprotective manner and protect cartilage stimulated to resorb with a combination of IL1alpha and oncostatin M (OSM), in a similar way to the anti-inflammatory cytokine, IL4...
  20. ncbi TIMP-1 is significantly associated with objective response and survival in metastatic colorectal cancer patients receiving combination of irinotecan, 5-fluorouracil, and folinic acid
    Nanna M Sørensen
    Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Cancer Res 13:4117-22. 2007
    ..We raised the hypothesis that elevated tumor tissue levels and thereby plasma levels of TIMP-1 would predict resistance to apoptosis-inducing chemotherapy...
  21. ncbi Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma
    B V Kallakury
    Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, USA
    Clin Cancer Res 7:3113-9. 2001
    ..More importantly, the recently documented paradoxical functions of TIMPs have not been characterized in these neoplasms...
  22. ncbi Matrix metalloproteinase-9 and its natural inhibitor TIMP-1 expressed or secreted by peripheral blood mononuclear cells from patients with systemic lupus erythematosus
    Cristiana Matache
    Department of Immunology, Cantacuzino National Institute of Research, Splaiul Independentei 103, Bucharest R 70 100, Romania
    J Autoimmun 20:323-31. 2003
    ..Taken together, these observations suggested the multiple roles of MMP-9 and TIMP-1 in progress of inflammation and tissue damage and/or in repair, depending on clinical stages of SLE...
  23. ncbi MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease
    D Cataldo
    Department of Pneumology, University of Liege, Liege, Belgium
    Int Arch Allergy Immunol 123:259-67. 2000
    ..The course of asthma and chronic obstructive pulmonary disease (COPD) is associated with bronchial morphological changes. Metalloproteinases are thought to play a role in these structural changes...
  24. ncbi Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and -9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2
    Muzahir H Tayebjee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, United Kingdom
    Thromb Res 115:205-10. 2005
    ..We therefore studied these aspects on plasma levels of MMP-2 and -9 and TIMP-1 and -2, as the major metalloproteinases (and their inhibitors) implicated in pathophysiology of vascular disease...
  25. ncbi Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas
    A E Kossakowska
    Department of Pathology, University of Calgary, Calgary Laboratory Services, Calgary, Alberta, Canada
    Blood 94:2080-9. 1999
    ..We postulate that IL-6 may play a role in the clinical aggressiveness of human NHL by stimulating MMP production...
  26. ncbi Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells
    Oualid Sbai
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie NICN, UMR 6184 CNRS Université de la Méditerranée, Faculte de Medecine, IFR Jean Roche, Bd Pierre Dramard, 13916 Marseille Cedex 20, France
    Mol Cell Neurosci 39:549-68. 2008
    ..Our results show differential trafficking of MMP and TIMP-1-containing vesicles in neuronal cells and suggest that these vesicles could play a role in neuronal and synaptic plasticity...
  27. ncbi Matrix metalloproteinases (MMPs) are required for re-epithelialization of cutaneous wounds
    M S Agren
    Department of Dermatology D92, Bispebjerg Hospital, University of Copenhagen, Denmark
    Arch Dermatol Res 291:583-90. 1999
    ..Our results suggest that MMPs are directly involved and necessary in epithelial resurfacing of moist skin wounds...
  28. ncbi Quantitative estimation of matrix metalloproteinases 2 and 7 (MMP-2, MMP-7) and tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1, TIMP-2) in colorectal carcinoma tissue samples
    M Pesta
    Central Laboratory of Radioisotopes, Charles University and Faculty Hospital, Pilsen, Czech Republic
    Anticancer Res 25:3387-91. 2005
    ..The aim of our study was to assess the levels of MMP-2, MMP-7, TIMP-1 and TIMP-2 mRNA expression in colorectal carcinoma tissue samples and to correlate them with the stage of the disease...
  29. pmc Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
    M Kajita
    Department of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Cell Biol 153:893-904. 2001
    ..These findings revealed a novel interaction of the two molecules that have each been implicated in tumor cell migration and invasion...
  30. ncbi TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src
    Seo Jin Lee
    Department of Biochemistry, College of Science, and Protein Network Research Center, Yonsei University, Seoul, Republic of Korea
    Biochem Biophys Res Commun 312:1196-201. 2003
    ..These findings demonstrate that the ability of TIMP-1 to inhibit apoptosis in T-47D cells is mediated by the sequential activation of pertussis toxin-sensitive G protein, c-Src, PI3 kinase, and Akt...
  31. ncbi Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis
    Victor Ruiz
    Instituto Nacional de Enfermedades Respiratorias, Mexico City, DF, CP 14080, Mexico
    Am J Physiol Lung Cell Mol Physiol 285:L1026-36. 2003
    ..Resistant animals behave as controls. These findings suggest that an imbalance between collagenases and TIMPs, excessive gelatinolytic activity, and epithelial apoptosis participate in the fibrotic response in this experimental model...
  32. pmc Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    A Ducharme
    Cardiovascular Division, Department of Medicine, and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:55-62. 2000
    ..The decrease in collagen accumulation and the enhanced expression of other MMPs suggest that MMP-9 plays a prominent role in extracellular matrix remodeling after MI...
  33. pmc Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia
    Radhika Suryadevara
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 44:47-56. 2003
    ..Our studies reveal new opportunities for repair-based therapeutic strategies in HAD...
  34. ncbi Divergent associations of tissue inhibitors of metalloproteinases-1 and -2 with the prothrombotic/fibrinolytic state
    Konstantinos Aznaouridis
    Atherosclerosis 195:212-5. 2007
  35. ncbi TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis
    Mark Bloomston
    Department of Surgery, University of South Florida, Tampa, Florida 33601, USA
    J Surg Res 102:39-44. 2002
    ..This study was undertaken to determine the effects of overexpression of a natural tissue inhibitor of MMP (TIMP-1) on pancreatic cancer cell growth, metastasis, and angiogenesis...
  36. ncbi Differential regulation of MMP-1/9 and TIMP-1 secretion in human monocytic cells in response to Mycobacterium tuberculosis
    J S Friedland
    Department of Infectious Diseases, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Matrix Biol 21:103-10. 2002
    ..Divergent effects of i on MMP and TIMP secretion from monocytes may be important in influencing matrix degradation in vivo...
  37. ncbi The role of C-C chemokines and their receptors in osteoarthritis
    G H Yuan
    St. Marianna University, Kawasaki, Japan
    Arthritis Rheum 44:1056-70. 2001
    ....
  38. ncbi Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair
    C Soo
    Department of Surgery, University of California at Los Angeles, 90095, USA
    Plast Reconstr Surg 105:638-47. 2000
    ..In conclusion, there is a distinct pattern of MMP and TIMP expression during normal excisional wound repair...
  39. pmc Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways
    Lisa A Ridnour
    Radiation Biology Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:16898-903. 2007
    ....
  40. pmc Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer
    Tae Dong Kim
    Department of Surgery, College of Medicine, Chungnam National University and Hospital, Daejeon, 301 721, Korea
    BMC Cancer 6:211. 2006
    ..We designed this study to determine any differences in the expression of MMP-2, MMP-9 and uPA system between colon and rectal cancer tissues...
  41. ncbi TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)
    M Kashiwagi
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 276:12501-4. 2001
    ..This provides a starting point for developing a biologically available aggrecanase inhibitor suitable for the treatment of arthritis...
  42. ncbi Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases
    B Vaillant
    Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 167:7017-26. 2001
    ..Indeed, our findings suggest that inhibiting profibrotic cytokines or specific MMP may be a more effective strategy to ameliorate fibrotic pathology...
  43. ncbi TIMP-1 alters susceptibility to carcinogenesis
    Jin Sae Rhee
    Medical Scientist Training Program, Cancer Research Institute, University of California, San Francisco, California, USA
    Cancer Res 64:952-61. 2004
    ..The combined implications of these studies suggest that TIMP-1 is an important contributor to epithelial neoplastic progression and supports the concept that TIMP-1 exerts differential regulation on tissues in a stage-dependent manner...
  44. ncbi Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study
    N J Peake
    Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Rheumatology (Oxford) 44:1383-9. 2005
    ....
  45. ncbi Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease
    Richard E K Russell
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science, London, United Kingdom
    Am J Respir Cell Mol Biol 26:602-9. 2002
    ....
  46. ncbi The significance of membrane type 1 metalloproteinase in structural involution of human corpora lutea
    Kengo Manase
    Department of Obstetrics and Gynecology, Cancer Research Institute, Sapporo Medical University School of Medicine, South 1 West 16 Chuo Ku, Japan
    Mol Hum Reprod 8:742-9. 2002
    ..These results suggest that increased expression of MT1-MMP may be a major factor in remodelling of the human corpus luteum during structural luteolysis...
  47. ncbi Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains
    Martin Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:141-50. 2002
    ....
  48. ncbi Novel functions of TIMPs in cell signaling
    Rosemarie Chirco
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Cancer Metastasis Rev 25:99-113. 2006
    ....
  49. ncbi Tissue inhibitor of metalloproteinase 1 adenoviral gene therapy alone is equally effective in reducing restenosis as combination gene therapy in a rabbit restenosis model
    Hanna L Puhakka
    A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    J Vasc Res 42:361-7. 2005
    ..vascular endothelial growth factor (VEGF)-A with VEGF-C is more effective than the combination of tissue inhibitor of metalloproteinase 1 (TIMP-1) alone or with VEGF-C in a rabbit balloon denudation model...
  50. ncbi Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen-induced arthritis
    F Apparailly
    INSERM U475, Montpellier, France
    Arthritis Rheum 44:1444-54. 2001
    ....
  51. ncbi Plasma levels of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 correlate with disease stage and survival in colorectal cancer patients
    Erwin T Waas
    Department of Surgery, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Dis Colon Rectum 48:700-10. 2005
    ..Our objective was to investigate the potential diagnostic and prognostic value of plasma matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 in colorectal cancer...
  52. pmc The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
    M D Sternlicht
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 98:137-46. 1999
    ..The premalignant and malignant lesions have stereotyped genomic changes unlike those seen in other murine mammary cancer models. These data indicate that Str1 influences tumor initiation and alters neoplastic risk...
  53. ncbi TIMP-1 as a tumor marker in breast cancer--an update
    Sidse O Würtz
    Department of Veterinary Pathobiology, Ridebanevej 9, University of Copenhagen, Faculty of Life Sciences, Frederiksberg C, Denmark
    Acta Oncol 47:580-90. 2008
    ..Furthermore, we link the clinical findings with studies of the molecular actions of the TIMP-1 protein, raising hypotheses that may explain why TIMP-1 could play an important role in future management of breast cancer patients...
  54. pmc Lung matrix metalloproteinase-9 correlates with cigarette smoking and obstruction of airflow
    Min Jong Kang
    Department of Internal Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea
    J Korean Med Sci 18:821-7. 2003
    ....
  55. ncbi Effect of latanoprost on the expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase 1 on the ocular surface
    Norihiko Honda
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Arch Ophthalmol 128:466-71. 2010
    ..To investigate the effect of topical latanoprost on the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase 1 (TIMP-1) on the ocular surface...
  56. ncbi Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker
    Nicolas Dagues
    Pfizer Global R and D, Drug Safety, Amboise, France
    Toxicol Sci 100:238-47. 2007
    ..Activation of genes coding for pro- and antioxidant enzymes, cytokines, adhesion molecules, and tissue inhibitor of metalloproteinase 1 (TIMP-1) indicates that biomechanical stimuli may contribute to vascular oxidant stress, ..
  57. ncbi Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway
    Xu Wen Liu
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:40364-72. 2003
    ..Taken together, the present study unveils some of the mechanisms mediating the anti-apoptotic effects of TIMP-1 in human breast epithelial cells through TIMP-1-specific signal transduction pathways...
  58. ncbi Increased expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) in a more tumourigenic colon cancer cell line
    R E Hewitt
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Pathol 192:455-9. 2000
    ..This association between TIMP-1 expression and tumour progression may be related to additional growth factor-like effects described for TIMP-1 in some systems...
  59. ncbi Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons
    Hiang Khoon Tan
    University Research Centre for Neuroendocrinology and MRC Centre for Synaptic Plasticity, University of Bristol, Marlborough Street, Bristol BS2 8HW, UK
    Mol Cell Neurosci 22:98-106. 2003
    ..These findings have a fundamental implication for our understanding of the physiological role of secreted TIMP-1 in the central nervous system...
  60. ncbi Impact of plasma tissue inhibitor of matrix metalloproteinase-1 on long-term survival in patients with colorectal cancer
    Norio Yukawa
    Department of Surgery, Yokohama City University, Yokohama, Japan
    Oncology 72:205-8. 2007
    ..Our results suggested that the preoperative plasma TIMP-1 concentration could be a useful prognosticator of long-term survival in patients with colorectal carcinoma...
  61. ncbi Serum tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1 and TIMP-2) levels in colorectal cancer patients: associations with clinicopathological variables and patient survival
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Int J Biol Markers 24:245-52. 2009
    ..0379 and p=0.0451, respectively). In conclusion, assessment of serum TIMP-1 can be considered a useful biomarker in colon cancer, whereas TIMP-2 appears to be of limited value...
  62. ncbi Both tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 activate Ras but through different pathways
    Ting Wang
    Department of Biochemistry, School of Dentistry, Aichi Gakuin University, 464 8650, Nagoya, Japan
    Biochem Biophys Res Commun 296:201-5. 2002
    ..Furthermore, TIMP-2 promoted the formation of a complex between Ras-GTP and phosphoinositide 3-kinase...
  63. ncbi Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway
    S Palejwala
    Department of Obstetrics, Gynecology, and Women's Health, New Jersey Medical School, Newark, New Jersey 07103, USA
    Endocrinology 142:3405-13. 2001
    ....
  64. pmc Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma
    Y Oshita
    First Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume 830 0011, Japan
    Thorax 58:757-60. 2003
    ..The role of these enzymes in the pathogenesis of asthma exacerbations is unknown...
  65. ncbi Peripheral neuropathy in systemic lupus erythematosus: pathomorphological features and distribution pattern of matrix metalloproteinases
    Christian Mawrin
    Institut für Neuropathologie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen, Aachen, Germany
    Acta Neuropathol 105:365-72. 2003
    ....
  66. ncbi Decreased MMP-9 activity in the serum of patients with diffuse cutaneous systemic sclerosis
    K Kikuchi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Exp Dermatol 27:301-5. 2002
    ..Serum MMP-9 activity and TIMP-1 level in patients with SSc were not correlated. Serum MMP-9 activity might be a useful indicator of disease activity, especially skin severity, in SSc patients...
  67. ncbi Johne's disease in cattle is associated with enhanced expression of genes encoding IL-5, GATA-3, tissue inhibitors of matrix metalloproteinases 1 and 2, and factors promoting apoptosis in peripheral blood mononuclear cells
    Paul M Coussens
    Center for Animal Functional Genomics, Department of Animal Science, Michigan State University, 1205H Anthony Hall, East Lansing, MI 4882, USA
    Vet Immunol Immunopathol 105:221-34. 2005
    ..paratuberculosis-infected cows are likely poised for rapid apoptosis (upregulation of CIDE-A, Bad, TNFRI, and Fas)...
  68. ncbi Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach
    Wael Kafienah
    University of Bristol, Bristol, UK
    Arthritis Rheum 48:709-18. 2003
    ..To determine if tissue-engineered cartilage can be protected from cytokine-induced degradation using a gene therapy approach...
  69. ncbi The balance between MMP-2/-9 and TIMP-1/-2 is shifted towards MMP in renal cell carcinomas and can be further disturbed by hydrogen peroxide
    Bernhard Hemmerlein
    Department of Pathology, University of Goettingen, D 37075 Gottingen, Germany
    Int J Oncol 24:1069-76. 2004
    ..In RCC the balance between MMP and TIMP is disturbed. Oxidative stress potentially increases this imbalance. TAM might be one source of hydrogen peroxide thus supporting the invasive properties of RCCs...
  70. ncbi Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts
    XiuXia Zhou
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:1388-97. 2007
    TGF-beta induces expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), a potent inhibitor of matrix metalloproteinases that controls extracellular matrix metabolism and deposition...
  71. ncbi Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma
    S V Culpitt
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Respir Med 99:703-10. 2005
    ..The MMP profile in COPD differs to that in asthma and cigarette smokers. This may contribute to, or be a marker of, different pathophysiologies of asthma and COPD...
  72. ncbi Primary tumor levels of tissue inhibitor of metalloproteinases-1 are predictive of resistance to chemotherapy in patients with metastatic breast cancer
    Anne Sofie Schrohl
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Clin Cancer Res 12:7054-8. 2006
    ....
  73. ncbi Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons
    Zubair Ahmed
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Mol Cell Neurosci 28:64-78. 2005
    ..These results suggest that activation of MMP and coincident down-regulation of TIMP may act to attenuate the inhibitory scarring in the regenerating ON, thus transforming the ON into a noninhibitory pathway for axon regrowth...
  74. ncbi Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers
    G Keyszer
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin Buch, Berlin, Germany
    J Rheumatol 26:251-8. 1999
    ....
  75. pmc Stromelysin-1 regulates adipogenesis during mammary gland involution
    C M Alexander
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706 1599, USA
    J Cell Biol 152:693-703. 2001
    ..We conclude that MMPs, especially Str1, determine the rate of adipocyte differentiation during involutive mammary gland remodeling...
  76. ncbi Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis
    Frank R Murphy
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Hampshire SO16 6YD, United Kingdom
    J Biol Chem 277:11069-76. 2002
    ..We conclude that TIMP-1 inhibits apoptosis of activated HSC via MMP inhibition...
  77. ncbi Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects
    K M Beeh
    Pulmonary Department, Internal Medicine University Hospital Mainz, Lagen beckstr 1, Main 2 55131, Germany
    Respir Med 97:634-9. 2003
    ..We have compared sputum concentrations of MMP-9, TIMP-1 and the controlling cytokine tumor necrosis factor (TNF)-alpha in patients with COPD, IPF and healthy subjects...
  78. ncbi Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents
    Barbara Głowińska-Olszewska
    2nd Department of Children s Diseases, Medical University of Białystok, 15 274 Białystok, Poland
    Metabolism 56:799-805. 2007
    ..It might be hypothesized that elevated MMP and TIMP concentrations may be related to increased cardiovascular risk in obese and particularly in obese hypertensive children and adolescents...
  79. ncbi Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment
    C Avolio
    Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    Mult Scler 11:441-6. 2005
    ..85; P < 0.05) of the numbers of MRI Gd-TD active lesions. These data confirm that serum MMP-9/TMIP-1 ratio may be viewed as a reliable marker and may be predictive of MRI activity in RR MS...
  80. ncbi Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent
    Valerie Gouyer
    Unité INSERM 560, Place de Verdun, Lille, France
    Cancer 103:1676-84. 2005
    ..In this study, mRNA expression levels of MMP-1, MMP-9, TIMP-1, and TIMP-2 were evaluated in patients with resected NSCLC, and their associations with disease progression and prognosis were determined...
  81. ncbi Metalloproteinase-9 is increased after toluene diisocyanate exposure in the induced sputum from patients with toluene diisocyanate-induced asthma
    H S Park
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    Clin Exp Allergy 33:113-8. 2003
    ..The aim of this study was to evaluate MMPs and TIMP involvement in toluene diisocyanate (TDI)-induced asthma...
  82. ncbi Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells
    Marie Fukushima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 25:829-38. 2005
    ..We investigated the effects of fasudil hydrochloride hydrate (fasudil), a Rho-kinase (ROCK) inhibitor, on cell growth, collagen production, and collagenase activity in HSCs...
  83. ncbi Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix meta
    Takashi Sato
    Department of Biochemistry, Tokyo University of Pharmacy and Life Science, School of Pharmacy, Hachioji, Tokyo 192 0392, Japan
    Cancer Res 62:1025-9. 2002
    ..Furthermore, we suggest a possible mechanism by which nobiletin may interfere in the phosphatidylinositol 3-kinase pathway, which divergently regulates the production of MMP and TIMP-1...
  84. ncbi Apolipoprotein E knockout mice over-expressing human tissue inhibitor of metalloproteinase 1 are protected against aneurysm formation but not against atherosclerotic plaque development
    Clarisse Cuaz-Pérolin
    INSERM U 545, Institut Pasteur de Lille, Departement d Atherosclerose, Lille, France
    J Vasc Res 43:493-501. 2006
    ..We investigated the effect of plasma levels of human tissue inhibitor of metalloproteinase (hTIMP)-1 on arterial lesion development and aneurysm formation in apolipoprotein-E-deficient mice (ApoE(-/-))...
  85. ncbi Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia
    Santiago Rivera
    IFR Jean Roche, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Eur J Neurosci 15:19-32. 2002
    ....
  86. ncbi Respiratory syncytial virus infection induces matrix metalloproteinase-9 expression in epithelial cells
    S J Yeo
    Department of Microbiology and Cancer Research Institute, SNUMRC, Seoul National University College of Medicine, Korea
    Arch Virol 147:229-42. 2002
    ..Thus, this study concludes that although RSV infection induces MMP-9, which can enhance the syncytia formation leading to RSV multiplication and spread it can be inhibited by MMP inhibitors...
  87. pmc Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer
    M N Holten Andersen
    The Finsen Laboratory, Copenhagen University Hospital, Denmark
    Br J Cancer 80:495-503. 1999
    ..It is proposed that plasma measurements of TIMP-1 may have value in the management of cancer patients...
  88. ncbi Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80218, USA
    Pediatr Pulmonol 39:224-32. 2005
    ..The observed relationships of MMP-9 with lung function and other measures of airway inflammation suggest that this enzyme may be a useful marker of airway injury and airflow obstruction in persons with CF...
  89. ncbi Matrix metalloproteinases in asthma and COPD
    Ingel K Demedts
    Department of Respiratory Diseases, Ghent University Hospital 7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium
    Curr Opin Pharmacol 5:257-63. 2005
    ..There is increasing evidence that MMPs are involved in the pathogenesis of both asthma and COPD, and several MMPs are possible therapeutic targets in these common chronic airway diseases...
  90. ncbi TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex
    Pawel Okulski
    Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland
    Biol Psychiatry 62:359-62. 2007
    ..The extracellular proteolytic system composed of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) has recently been shown to play major role in the hippocampal plasticity...
  91. ncbi Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways
    J M Milner
    Department of Rheumatology, The Medical School, University of Newcastle-upon-Tyne, England, UK
    Arthritis Rheum 44:2084-96. 2001
    ..CONCLUSION: The activation of procollagenases is a key control point in cartilage collagen breakdown, and serine proteinase pathways activate MMPs...
  92. ncbi Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma
    Y Ogata
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Kurume Med J 48:211-8. 2001
    ..These results suggest that the balance between the expressions of MMP-9 and TIMP-1 in the tumor cells is more closely related to tumor biological behavior rather than the balance in the stromal cells...
  93. ncbi Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis
    A Shaida
    Department of Otolaryngology, St Bartholomew's and the Royal London School of Medicine and Dentistry, United Kingdom
    J Allergy Clin Immunol 108:791-6. 2001
    ..There is no upregulation of MMPs or changes in TIMP expression in the nasal mucosa of patients with allergic rhinitis...
  94. ncbi Increased matrix metalloproteinase 9 activity and mRNA expression in lung ischemia-reperfusion injury
    M Yano
    Department of Surgery II, Nagoya City University School of Medicine, Nagoya, Japan
    J Heart Lung Transplant 20:679-86. 2001
    ..We evaluated the changes in the activity of MMP-2 and MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) gene expressions using rat lung transplantation models...
  95. ncbi Suppressive activity of fexofenadine hydrochloride on metalloproteinase production from nasal fibroblasts in vitro
    K Asano
    Department of Physiology, School of Medicine, Showa University, Tokyo 142 8555, Japan
    Clin Exp Allergy 34:1890-8. 2004
    ..Matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are the major proteolytic enzymes that induce airway remodelling. These enzymes are also important in the migration of inflammatory cells through basement membrane components...
  96. ncbi Increased expression of tissue inhibitor of metalloproteinase-2 in clear cell carcinoma of the ovary
    Tomomitsu Okamoto
    Department of Obstetrics and Gynaecology, Chukyo Hospital, 1 1 10, Sanjo, Minami Ku, Nagoya 457 8510, Japan
    Mol Hum Reprod 9:569-75. 2003
    ..Taken together, the present study shows that TIMP-2 expression is markedly increased in clear cell carcinoma of the ovary, suggesting a role of TIMP-2 in its unique characteristics among ovarian cancers...
  97. ncbi Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma
    Nozomu Kawata
    Department of Urology, Nihon University School of Medicine, Tokyo, Japan
    Urology 69:1049-53. 2007
    ....
  98. ncbi Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma
    M Mori
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Int J Cancer 88:575-8. 2000
    ..Our findings suggest that TIMP-1 expression correlates with tumor extension of esophageal carcinoma and might, if validated, prove useful as a novel prognostic marker for esophageal carcinoma...
  99. ncbi Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis
    A Katrib
    Rheumatology Unit, Prince of Wales Hospital, Inflammation Research Unit, School of Pathology, University of New South Wales, Sydney, Australia
    Rheumatology (Oxford) 40:988-94. 2001
    ..Targeting chemokines which play a role in the migration of macrophages into the joints may be of therapeutic benefit in RA patients...
  100. ncbi Expression levels of vascular endothelial growth factor, matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 and 2 in the plasma of patients with ovarian carcinoma
    L Manenti
    Department of Oncology, Mario Negri Institute for Pharmacological Research, 24125 Bergamo, Italy
    Eur J Cancer 39:1948-56. 2003
    ..Throughout the study, and in the univariate analysis, no correlation was found between the VEGF, MMP and TIMP levels. Only TIMP-1 was associated with a poor survival and mortality risk...
  101. ncbi Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers
    Steven Young-Min
    Queen Alexandra Hospital, Portsmouth, UK
    Arthritis Rheum 56:3236-47. 2007
    ..To evaluate the performance of biochemical and traditional markers in predicting radiographic progression in rheumatoid arthritis (RA)...

Research Grants67

  1. Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque Formation
    Suresh C Tyagi; Fiscal Year: 2013
    ..The results of the proposed research should uncover the molecular mechanisms regulating Hcy-Fg-Ab-collagen complex formation and lead to effective strategies for the treatment of cerebrovascular complications during diseases such as AD. ..
  2. Mechanisms of Reduced Fecundity in Endometriosis: A role for MMPs and TIMPs
    KATHY L TIMMS; Fiscal Year: 2012
    ..abstract_text> ..
  3. Spinal Matrix Metalloproteinases in Hyperalgesia and Allodynia
    CHRISTINA CHRISTIANSON; Fiscal Year: 2010
    ..localization of matrix metalloproteinase 3 (MMP-3), and associated regulatory proteins such as tissue inhibitor of metalloproteinase 1 (TIMP-1), and osteopontin in a model of inflammatory pain...
  4. ACE Inhibition and Novel Cardiovascular Risk Factors
    Marco Pahor; Fiscal Year: 2004
    ..abstract_text> ..
  5. The Role and Regulation of TIMP-1 in Lung Inflammation
    DAVID MADTES; Fiscal Year: 2005
    ..Studies are proposed to define if CD4O induces TIMP-1 translation by usage of alternative 5' transcription start sites, increased transcript translocation or increased translational efficiency. ..
  6. Estrogen regulation of uterine microRNAs: Novel factors in MMP-9 regulation
    Warren Nothnick; Fiscal Year: 2008
    ..Enhancing our understanding on the regulation of MMP-9 expression may lead to the establishment of novel approaches to counteract mis-expression of this protease and the diseases associated with it. [unreadable] [unreadable] [unreadable]..
  7. The Role of TIMP-1 in Uterine Physiology
    Warren Nothnick; Fiscal Year: 2005
    ..These studies will broaden our understanding on the role of TIMP-1 in uterine physiology and may help to develop new strategies to treat uterine disorders such as infertility, endometriosis and uterine cancer. ..
  8. Collagenolysis and Elastolysis in Urinary Incontinence
    Bertha Chen; Fiscal Year: 2008
    ..Our goal is to identify specific pathophysiologic changes related to reproductive events and aging which underlie the development of SUI as a first step to identifying potential targets for therapeutic intervention. ..
  9. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  10. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2007
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. [unreadable] [unreadable]..
  11. IL-10 Regulation of Lymphangiogenesis in Prostate Cancer
    Mark Stearns; Fiscal Year: 2008
    ..Overall, the studies should demonstrate whether the IL-10R axis and down stream effector genes (and specifically IL-10S1-VEGF D, and VEGF D) play a pivotal role in lymphangiogenesis and/or angiogenesis processes. ..
  12. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2003
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  13. IL10 and IGF1 Receptor Axis in Prostate Cancer
    Mark Stearns; Fiscal Year: 2005
    ..Development of therapeutic agents, which target the IL-10R or IGF-R1 axis should be beneficial in the treatment of the disease. ..
  14. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  15. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  16. ROLE OF TIMPS AND MMPS IN CORNEAL ULCERATION
    KAREN KERNACKI; Fiscal Year: 2004
    ..Aim 4: To similarly examine specific TIMPs (TIMP-1 and -4) in the pathogenesis of corneal alkali-burn in inbred mice using moderate vs severe burns. ..
  17. High Throughput Real-Time PCR System for the Microarray Core
    Richard Dennis; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. Novel Roles for MMP-8 in Acute Lung Injury
    Caroline Owen; Fiscal Year: 2008
    ..We anticipate that in the future, our studies will facilitate the development of new treatment strategies that may reduce mortality and morbidity in ALl syndromes. ..
  19. Pilot Testing of VEGF/PDGF inhibitors for chemoprevention of bone metastasis
    Hyeong Reh Kim; Fiscal Year: 2007
    ..This information will be useful in designing more rational therapeutic interventions aimed at modulating the PDGF/VEGF signaling pathways. [unreadable] [unreadable] [unreadable]..
  20. Tissue Kallikrein, Oxidative Stress and Renal Fibrosis
    Julie Chao; Fiscal Year: 2007
    ..abstract_text> ..
  21. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..We will use these results to design a multicenter clinical trial evaluating the diagnostic and prognostic value of ECM1 and TMPRSS4 expression in patients with thyroid neoplasm. [unreadable] [unreadable] [unreadable]..
  22. Urokinase-type Plasminogen Activator System and Pancreatic Stellate Cells
    Aurelia Lugea; Fiscal Year: 2007
    ..Therapeutic strategies focusing on the regulation of uPA activation may be central in preventing or reverting alcohol-induced pancreas fibrosis. [unreadable] [unreadable] [unreadable]..
  23. LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS
    Jenny Mao; Fiscal Year: 2007
    ..The finding from this pilot project will provide important insight into the design and conduct of future chemopreventive trials. ..
  24. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Matrix Metalloproteinases in Gastric Injury
    Emily Robinson; Fiscal Year: 2008
    ..These facilities as well as close guidance and supervision from her sponsor will ensure success of the proposed project. [unreadable] [unreadable]..
  26. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  27. Vascular Protection & Endothelin B Receptors in Diabetes
    Adviye Ergul; Fiscal Year: 2009
    ..abstract_text> ..
  28. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  29. Tumor metastasis: Biobehavioral mechanisms
    Anil K Sood; Fiscal Year: 2009
    ....
  30. Mechanism of Vascular Remodeling in Hyperhomocysteinemia
    Suresh C Tyagi; Fiscal Year: 2010
    ..This study will provide new insights into the mechanism of arterial remodeling and will have therapeutic ramifications for vessel wall disease. ..
  31. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..These studies will delineate the mechanism of Hcy-dependent endothelial-myocyte uncoupling in cardiac arrhythmia and failure, and will have therapeutic ramifications for sudden cardiac death. ..
  32. Novel Roles for ADAM15 in Acute Lung Injury
    Caroline A Owen; Fiscal Year: 2010
    ..abstract_text> ..
  33. Molecular Analysis of the Human Aqueous Outflow Pathway
    Michael P Fautsch; Fiscal Year: 2010
    ..We will also determine gene and protein expression changes in the meshwork induced by normal and POAG aqueous humor. Develop a medium that can be used to mimic aqueous humor for trabecular meshwork cell culture. ..
  34. RELAXIN FAMILY PEPTIDES AND HEPATIC FIBROSIS
    Robert Bennett; Fiscal Year: 2009
    ..The research proposed in this application may lead to targeted therapeutic strategies for the treatment of liver disease, a major health concern in the United States. ..
  35. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  36. Chemokine induced hematopoietic stem cell mobilization
    LOUIS PELUS; Fiscal Year: 2009
    ....
  37. Pressure Induced Dynamic 3D Changes in Lamina Cribrosa
    Donald Brown; Fiscal Year: 2008
    ..This technique allows for direct measurement of the structural changes in the associated with glaucoma and has direct clinical relevance and application. [unreadable] [unreadable] [unreadable]..
  38. Estrogen and Aging effects on Transvaginal Transport
    George Gorodeski; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  40. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  41. CD Expression in Prostate Cancer
    Alvin Liu; Fiscal Year: 2004
    ..CD10 and CD13 are both peptidases and are likely involved in the processing of bioactive signaling peptides. Their absence might lead to the aberrant cellular differentiation and development of cancer. ..
  42. 1Treatment of Cholestatic Pruritus With Sertraline
    MARLYN MAYO; Fiscal Year: 2004
    ..These studies will serve as pilot trials. The results of this proposed project will be used to design a larger controlled trial that could be proposed for funding through an R01 mechanism. ..
  43. ROLE OF CD40-CD40 LIGAND IN PRIMARY BILIARY CIRRHOSIS
    MARLYN MAYO; Fiscal Year: 2003
    ..These studies will provide insight into the role of T cells in the pathogenesis of PBC and provide information useful in developing new treatment modalities. ..
  44. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..
  45. SCLERODERMA LUNG STUDY
    David Riley; Fiscal Year: 2003
    ..abstract_text> ..
  46. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  47. EXTRACELLULAR MATRIX ABNORMALITIES IN CORNEAL EDEMA
    MARIA KENNEY; Fiscal Year: 2002
    ....
  48. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  49. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..
  50. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  51. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..The results of this study are essential to understand the molecular basis of deranged metabolism in sepsis. Understanding the mechanism might be useful for developing appropriate therapeutic intervention during sepsis. ..
  52. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  53. Mast Cell Role in Masseter Muscle Repair
    JOYCE MORRIS WIMAN; Fiscal Year: 2005
    ....
  54. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  55. Role of Fibroblast-Derived MT1-MMP in Oral Cancer
    Eben Rosenthal; Fiscal Year: 2006
    ..abstract_text> ..
  56. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  58. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  59. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  60. Urologic Epithelial Stem Cells
    Alvin Liu; Fiscal Year: 2004
    ....
  61. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  62. BIOLOGICAL EFFECTS OF BASIC CALCIUM PHOSPHATE CRYSTALS
    Herman Cheung; Fiscal Year: 2004
    ..Hypothesis 5: There are specific cis elements in the promotor of Tissue Inhibitor of Metalloproteinase (TIMP)-2 that regulate crystal inhibition of TIMP- 2 expression. ..
  63. C1Q-INDUCED CA2+ RESPONSES IN FIBROBLAST HETEROGENEITY
    Sandra Bordin; Fiscal Year: 2002
    ..While this work focuses on periodontitis, its results should be applicable to a variety of inflammatory diseases as well as wound healing. ..
  64. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  65. 800 MHz Spectrometer for Biomolecular NMR in Missouri
    STEVEN VAN DOREN; Fiscal Year: 2006
    ..The CdtB subunit is sufficient to cause DNA damage and to arrest the cell cycle in mammalian cells. [unreadable] [unreadable]..
  66. Identification of Serum Markers of Liver Fibrogenesis/ Fibrolysis by Proteomics
    Detlef Schuppan; Fiscal Year: 2008
    ..Adaptation to the human proteome and prospective validation shall allow noninvasive monitoring of fibrosis progression and regression in patients with liver diseases. [unreadable] [unreadable] [unreadable]..
  67. Mouse Models for Celiac Disease
    Detlef Schuppan; Fiscal Year: 2007
    ..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..