gelatin

Summary

Summary: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.

Top Publications

  1. ncbi A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomaterials 33:2372-87. 2012
  2. ncbi Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells
    Shirzad Azarmi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 9:124-32. 2006
  3. ncbi Structure and properties of bilayer chitosan-gelatin scaffolds
    Jin Shu Mao
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China
    Biomaterials 24:1067-74. 2003
  4. ncbi Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
    Y Nakano
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
    J Biochem 120:803-12. 1996
  5. ncbi Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering
    Chih Hung Chang
    Institute of Biomedical Engineering, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan, ROC
    Biomaterials 24:4853-8. 2003
  6. ncbi Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells
    Javier Ramón-Azcón
    WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan
    Lab Chip 12:2959-69. 2012
  7. ncbi In vitro growth factor release from injectable calcium phosphate cements containing gelatin microspheres
    W J E M Habraken
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 91:614-22. 2009
  8. ncbi Synthesis of gelatin-stabilized gold nanoparticles and assembly of carboxylic single-walled carbon nanotubes/Au composites for cytosensing and drug uptake
    Jing jing Zhang
    Key Laboratory of Analytical Chemistry for Life Science Ministry of Education of China, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Anal Chem 81:6641-8. 2009
  9. ncbi Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, 33302, Taoyuan, Taiwan, Republic of China
    J Mater Sci Mater Med 21:1899-911. 2010
  10. ncbi Gelatin as a delivery vehicle for the controlled release of bioactive molecules
    Simon Young
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    J Control Release 109:256-74. 2005

Detail Information

Publications402 found, 100 shown here

  1. ncbi A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomaterials 33:2372-87. 2012
    In this study, the aminated gelatin was grafted with carboxylic end-capped poly(N-isopropylacrylamide) (PN) via a carbodiimide-mediated coupling reaction to fabricate biodegradable in situ forming delivery systems for intracameral ..
  2. ncbi Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells
    Shirzad Azarmi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 9:124-32. 2006
    ....
  3. ncbi Structure and properties of bilayer chitosan-gelatin scaffolds
    Jin Shu Mao
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China
    Biomaterials 24:1067-74. 2003
    Chitosan-gelatin hybrid polymer network scaffolds were prepared via the freeze-drying technique by using the ice microparticle as a porogen. Monolayer and bilayer scaffolds were obtained by using different pre-freezing methods...
  4. ncbi Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
    Y Nakano
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
    J Biochem 120:803-12. 1996
    By use of its affinity to gelatin-Cellulofine, a novel protein, GBP28 (gelatin-binding protein of 28 kDa), was obtained from human plasma. GBP28 bound to gelatin-Cellulofine could be eluted with 1 M NaCl...
  5. ncbi Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering
    Chih Hung Chang
    Institute of Biomedical Engineering, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan, ROC
    Biomaterials 24:4853-8. 2003
    ..The aim of the present work was to produce a gelatin/chondoitin-6-sulfate/hyaluronan tri-copolymer to mimic natural cartilage matrix for use as a scaffold for ..
  6. ncbi Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells
    Javier Ramón-Azcón
    WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan
    Lab Chip 12:2959-69. 2012
    ..In this study, we propose gelatin methacrylate (GelMA) as a promising hydrogel for use in cell dielectropatterning because of its biocompatibility ..
  7. ncbi In vitro growth factor release from injectable calcium phosphate cements containing gelatin microspheres
    W J E M Habraken
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 91:614-22. 2009
    ..purposes, in previous experiments macroporosity was introduced by the in situ degradation of incorporated gelatin microspheres...
  8. ncbi Synthesis of gelatin-stabilized gold nanoparticles and assembly of carboxylic single-walled carbon nanotubes/Au composites for cytosensing and drug uptake
    Jing jing Zhang
    Key Laboratory of Analytical Chemistry for Life Science Ministry of Education of China, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Anal Chem 81:6641-8. 2009
    b>Gelatin-stabilized gold nanoparticles (AuNPs-gelatin) with hydrophilic and biocompatible were prepared with a simple and "green" route by reducing in situ tetrachloroauric acid in gelatin...
  9. ncbi Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, 33302, Taoyuan, Taiwan, Republic of China
    J Mater Sci Mater Med 21:1899-911. 2010
    ..study, we investigated the effect of cross-linker functionality on ocular biocompatibility of chemically modified gelatin hydrogels...
  10. ncbi Gelatin as a delivery vehicle for the controlled release of bioactive molecules
    Simon Young
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    J Control Release 109:256-74. 2005
    b>Gelatin is a commonly used natural polymer which is derived from collagen...
  11. ncbi In situ localization of gelatinolytic activity in the extracellular matrix of metastases of colon cancer in rat liver using quenched fluorogenic DQ-gelatin
    Olaf R F Mook
    Academic Medical Centre, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
    J Histochem Cytochem 51:821-9. 2003
    ..We demonstrated with gelatin zymography that the tumors contained MMP-2 and MMP-9, but only MMP-2 was present in the active form...
  12. ncbi The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel
    Kazunari Ishida
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Tissue Eng 13:1103-12. 2007
    ..5-mm-diameter full-thickness defects were created in the avascular region of rabbit meniscus. Gelatin hydrogel (GH) was used as the drug delivery system for PRP growth factors...
  13. ncbi Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution
    E J Chong
    Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Acta Biomater 3:321-30. 2007
    ....
  14. ncbi Preparation of hydroxyapatite-gelatin nanocomposite
    Myung Chul Chang
    MDRCBB, School of Dentistry, University of Minnesota, 16 280 Moos Tower, 515 Delaware S E Minneapolis, MN 55455 0329, USA
    Biomaterials 24:2853-62. 2003
    A nanocomposite of gelatin[GEL]-hydroxyapatite[HAp] was prepared using the biomimetic process. The hydroxyapatite nanocrystals were precipitated in aqueous solution of gelatin at pH 8 and 38 degrees C...
  15. ncbi Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
    ..Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids...
  16. ncbi Bone regeneration using a bone morphogenetic protein-2 saturated slow-release gelatin hydrogel sheet: evaluation in a canine orbital floor fracture model
    Shinichi Asamura
    Department of Plastic and Reconstructive Surgery, Kinki University School of Medicine, Osaka, Japan
    Ann Plast Surg 64:496-502. 2010
    ..In this study, such a system was applied, using gelatin hydrogel as a carrier to slowly release (bone morphogenetic proteins) BMP-2 over a relatively long period in vivo...
  17. ncbi Secreted production of a custom-designed, highly hydrophilic gelatin in Pichia pastoris
    M W Werten
    Agrotechnological Research Institute ATO BV, Bornsesteeg 59, 6708 PD Wageningen, The Netherlands
    Protein Eng 14:447-54. 2001
    A custom-designed, highly hydrophilic gelatin was produced in Pichia pastoris...
  18. pmc Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
    Y Itoh
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    EMBO J 20:4782-93. 2001
    ..These findings elucidate a new function of the PEX domain: regulating MT1-MMP activity on the cell surface, which accelerates cellular invasiveness in the tissue...
  19. ncbi Novel silk sericin/gelatin 3-D scaffolds and 2-D films: fabrication and characterization for potential tissue engineering applications
    Biman B Mandal
    Department of Biotechnology, Indian Institute of Technology, Kharagpur 721302, India
    Acta Biomater 5:3007-20. 2009
    In this study, we report for the first time the fabrication of novel 3-D sericin/gelatin scaffolds and 2-D films using non-mulberry Antheraea mylitta silk cocoon sericin protein...
  20. ncbi In vitro uptake of gelatin nanoparticles by murine dendritic cells and their intracellular localisation
    Conrad Coester
    Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada
    Eur J Pharm Biopharm 62:306-14. 2006
    ..is to develop an efficient nanoscopic vaccine delivery system, based on the biodegradable and natural polymer gelatin, to deliver therapeutic protein antigens along with adjuvants into dendritic cells (DCs)...
  21. ncbi Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice
    Sushma Kommareddy
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    J Pharm Sci 96:397-407. 2007
    The objective of the present study was to modify thiolated gelatin nanoparticles with poly(ethylene glycol) (PEG) chains and examine their long circulating and tumor-targeting properties in vivo in an orthotopic a human breast ..
  22. ncbi Synthesis and characterization of elastic and macroporous chitosan-gelatin cryogels for tissue engineering
    Neeraj Kathuria
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India
    Acta Biomater 5:406-18. 2009
    Elastic chitosan-gelatin cryogels of varying concentration of polymer precursors have been synthesized using glutaraldehyde as a crosslinking agent...
  23. ncbi Fast detection of humidity with a subwavelength-diameter fiber taper coated with gelatin film
    Lei Zhang
    State Key Lab of Modern Optical Instrumentation Zhejiang University, Hangzhou 310027, China
    Opt Express 16:13349-53. 2008
    A subwavelength-diameter tapered optical fiber coated with gelatin layer for fast relative humidity (RH) sensing is reported...
  24. ncbi Effect of charge and molecular weight on the functionality of gelatin carriers for corneal endothelial cell therapy
    Jui Yang Lai
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, ROC
    Biomacromolecules 7:1836-44. 2006
    ..In this work, a cell-adhesive gelatin hydrogel carrier was fabricated to deliver cultivated human corneal endothelial cell (HCEC) sheets, which were ..
  25. pmc The terminal immunoglobulin-like repeats of LigA and LigB of Leptospira enhance their binding to gelatin binding domain of fibronectin and host cells
    Yi Pin Lin
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 5:e11301. 2010
    ..In this study, the gelatin binding domain of fibronectin was shown to interact with LigBCen2R (K(D) = 1.91+/-0.40 microM)...
  26. ncbi Bone marrow mesenchymal stem cells in a three-dimensional gelatin sponge scaffold attenuate inflammation, promote angiogenesis, and reduce cavity formation in experimental spinal cord injury
    Xiang Zeng
    Research center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, China
    Cell Transplant 20:1881-99. 2011
    Three-dimensional (3D) gelatin sponge (GS) scaffolds were constructed by ensheathing GS with a thin film of poly-(lactide-co-glycolide) (PLGA)...
  27. ncbi Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin
    Biji Balakrishnan
    Division of Polymer Chemistry, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum, Kerala 695 012, India
    Biomaterials 26:6335-42. 2005
    ..Here we describe such an in situ forming hydrogel wound dressing from gelatin, oxidized alginate and borax...
  28. ncbi Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography
    Marta Toth
    Department of Pathology, School of Medicine, Proteases and Cancer Program, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Methods Mol Biol 878:121-35. 2012
    b>Gelatin zymography is a simple yet powerful method to detect proteolytic enzymes capable of degrading gelatin from various biological sources...
  29. ncbi Studies on the characteristics of drug-loaded gelatin nanoparticles prepared by nanoprecipitation
    Eun Ju Lee
    Department of Chemical Engineering, College of Engineering, Kyungpook National University, Daegu, 702 701, Korea
    Bioprocess Biosyst Eng 35:297-307. 2012
    The morphology of gelatin nanoparticles loaded with three different drugs (Tizanidine hydrochloride, Gatifloxacin and Fluconazole) and their characteristics of entrapment and release from gelatin nanoparticles were investigated by the ..
  30. pmc Gelatin in situ zymography on fixed, paraffin-embedded tissue: zinc and ethanol fixation preserve enzyme activity
    Elin Hadler-Olsen
    Institute of Medical Biology, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway
    J Histochem Cytochem 58:29-39. 2010
    ..The yield, as analyzed by SDS-PAGE gelatin zymography and Western blotting, was influenced by the composition of the extraction buffer, but was generally ..
  31. ncbi Synthesis of silver nanoparticles in chitosan, gelatin and chitosan/gelatin bionanocomposites by a chemical reducing agent and their characterization
    Mansor Bin Ahmad
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia
    Molecules 16:7237-48. 2011
    In this research, silver nanoparticles (AgNPs) were synthesized in chitosan (Cts), Cts/gelatin and gelatin suspensions using a chemical reducing agent...
  32. pmc Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2
    Zarana S Patel
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, United States
    Acta Biomater 4:1126-38. 2008
    This work evaluated gelatin microparticles and biodegradable composite scaffolds for the controlled release of bone morphogenetic protein-2 (BMP-2) in vitro and in vivo...
  33. pmc Green synthesis and characterization of gelatin-based and sugar-reduced silver nanoparticles
    Majid Darroudi
    Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology ITMA, Universiti Putra Malaysia, Selangor, Malaysia
    Int J Nanomedicine 6:569-74. 2011
    ..have been successfully prepared with simple and "green" synthesis method by reducing Ag(+) ions in aqueous gelatin media with and in the absence of glucose as a reducing agent...
  34. ncbi Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B
    Sanyog Jain
    Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar Mohali, Punjab 160062, India
    Mol Pharm 9:2542-53. 2012
    ..Amphotericin B (AmB) loaded polymer lipid hybrid nanoparticles (AmB-PLNs) comprised of lecithin (anionic lipid) and gelatin (Type A, cationic below its isoelectric point 7.0-9...
  35. ncbi A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation
    Ryou Watanabe
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tissue Eng Part A 17:2213-9. 2011
    We examined the feasibility of using gelatin hydrogels as carrier sheets for the transplantation of cultivated corneal endothelial cells...
  36. ncbi Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method
    X Wu
    School of Science, Tianjin University, Tianjin 300072, China
    Acta Biomater 6:1167-77. 2010
    Porous gelatin scaffolds with microtubule orientation structure were manufactured by unidirectional freeze-drying technology, and their porous structure was characterized by scanning electron microscopy...
  37. pmc Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Int J Nanomedicine 7:1101-14. 2012
    ..occurring biopolymers as three-dimensional corneal keratocyte scaffolds and suggest that the porous structure of gelatin materials may play an important role in controlling nutrient uptake...
  38. pmc Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/ polycaprolactone membranes
    Huichuan Duan
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai, People s Republic of China
    Int J Nanomedicine 8:2077-84. 2013
    ..The aim of this study was to investigate the feasibility of a modified gelatin and polycaprolactone (GT/PCL) electrospun membrane for epidermis engineering...
  39. ncbi Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure
    Antonio Cittadini
    Department of Internal Medicine and Cardiovascular Sciences, University Federico II, Via Sergio Pansini 5, Naples, Italy
    Eur J Heart Fail 13:1264-74. 2011
    ..Our aim was to investigate the effects of sequential release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) from biodegradable gelatin microspheres in experimental heart failure.
  40. ncbi Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell Orientation
    Zuwei Ma
    Nanoscience and Nanotechnology Initiative, National University of Singapore
    Tissue Eng 11:1149-58. 2005
    ..To graft gelatin on the nanofiber surface, PCL nanofibers were first treated with air plasma to introduce -COOH groups on the ..
  41. ncbi Enhanced differentiation of mesenchymal stem cells co-cultured with ligament fibroblasts on gelatin/silk fibroin hybrid scaffold
    Hongbin Fan
    Department of Orthopaedic Surgery, National University of Singapore, 10 Kent Ridge Crescent, Singapore, Singapore
    Biomaterials 29:1017-27. 2008
    ..A kind of silk cable-reinforced gelatin/silk fibroin hybrid scaffold was used to provide three-dimensional (3-D) culture environments for MSCs...
  42. ncbi Chitosan-gelatin scaffolds for tissue engineering: physico-chemical properties and biological response of buffalo embryonic stem cells and transfectant of GFP-buffalo embryonic stem cells
    W W Thein-Han
    Biomaterials and Biomedical Engineering Research Laboratory, Center for Structural and Functional Materials, University of Louisiana at Lafayette, PO Box 44130, Lafayette, LA 70504 4130, USA
    Acta Biomater 5:3453-66. 2009
    ..of newly developed cell line, buffalo embryonic stem (ES) cells to three-dimensional biodegradable chitosan-gelatin composite scaffolds with regard to stem-cell-based tissue engineering is described...
  43. ncbi Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation
    Amandeep Kaur
    Department of Pharmaceutical Sciences, Drug Research Punjabi University, Patiala, Punjab, 147 002, India
    Acta Pharm 58:61-74. 2008
    ..4). Results of the present study showed that the mannan-coated nanoparticles targeted didanosine to the macrophage by mannosyl receptor mediated endocytosis...
  44. ncbi In vitro and in vivo degradability and cytocompatibility of poly(l-lactic acid) scaffold fabricated by a gelatin particle leaching method
    Yihong Gong
    Department of Polymer Science and Engineering, Zhejiang University, Key Laboratory of Macromolecule Synthesis and Functionalization, Ministry of Education, Hangzhou 310027, China
    Acta Biomater 3:531-40. 2007
    Porous poly(l-lactic acid) (PLLA) scaffolds fabricated by a gelatin particle-leaching technique have good mechanical property and cytocompatibility, as demonstrated by a previous in vitro study...
  45. ncbi Study of gelatin-containing artificial skin V: fabrication of gelatin scaffolds using a salt-leaching method
    Sang Bong Lee
    School of Chemical Engineering, College of Engineering, Hanyang University, Haengdang dong, Seungdong ku, Seoul 133 791, Republic of Korea
    Biomaterials 26:1961-8. 2005
    Porous gelatin scaffolds were prepared using a salt-leaching method and these were compared to scaffolds fabricated using a freeze-drying method...
  46. ncbi Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules
    Keng Shiang Huang
    Dept of Biomedical Engineering, I Shou University, Taiwan
    J Control Release 137:15-9. 2009
    This paper demonstrates a proof-of-concept approach for producing genipin-gelatin microcapsules of precisely controlled and monodisperse size distributions by the microfluidic channels...
  47. ncbi Delivery by cationic gelatin nanoparticles strongly increases the immunostimulatory effects of CpG oligonucleotides
    Klaus Zwiorek
    Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig Maximilians University, Butenandtstr 5 13, 81377, Munich, Germany
    Pharm Res 25:551-62. 2008
    Cationized gelatin nanoparticles (GNPs) were used as carrier to improve delivery of immunostimulatory CpG oligonucleotides (CpG ODN) both in vitro and in vivo.
  48. ncbi Novel approach to fabricate porous gelatin-siloxane hybrids for bone tissue engineering
    Lei Ren
    Biomaterial Laboratory, Faculty of Engineering, Okayama University, Tsushima, Okayama shi 700 8530, Japan
    Biomaterials 23:4765-73. 2002
    Porous and bioactive gelatin-siloxane hybrids were successfully synthesized by using a combined sol-gel processing, post-gelation soaking, and freeze-drying process to provide a novel kind of materials in the developments and ..
  49. ncbi Ultrasound enhancement of in vitro transfection of plasmid DNA by a cationized gelatin
    Hossein Hosseinkhani
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Drug Target 10:193-204. 2002
    ..Ethylenediamine was introduced to the carboxyl groups of gelatin to prepare a cationized gelatin as the vector of plasmid DNA encoding luciferase...
  50. ncbi Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate
    S K Kim
    Department of Chemistry, Pukyong National University, Pusan 608 737, Korea
    J Agric Food Chem 49:2992-7. 2001
    Bovine skin gelatin was hydrolyzed with sequential protease treatments in the order of Alcalase, Pronase E, and collagenase using a three-step ultrafiltration membrane reactor...
  51. ncbi Functional assessment of cross-linked porous gelatin hydrogels for bioengineered cell sheet carriers
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomacromolecules 11:1387-97. 2010
    ..Here we introduced a simple stirring process combined with freeze-drying (SFD1) method for the development of gelatin hydrogels with enlarged pore structure that can improve the aqueous humor circulation...
  52. ncbi Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate
    Yoshitake Takahashi
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 26:4856-65. 2005
    Biodegradable gelatin sponges at different contents of beta-tricalcium phosphate (beta-TCP) were fabricated to allow bone morphogenetic protein (BMP)-2 to incorporate into them...
  53. pmc Trypsin-like serine proteases in Lutzomyia longipalpis--expression, activity and possible modulation by Leishmania infantum chagasi
    Erich Loza Telleria
    Laboratório de Biologia Molecular de Parasitas e Vetores, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 5:e10697. 2010
    ..We have now characterized the expression and activity of trypsin-like proteases of Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil...
  54. ncbi Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    NUS Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore
    Biomaterials 29:4532-9. 2008
    ..Random and aligned PCL/gelatin biocomposite scaffolds were fabricated by varying the ratios of PCL and gelatin concentrations...
  55. ncbi Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix
    Lars Bryngelson Ohlsson
    Department of Cell and Molecular Biology, Section for Tumor Immunology, Lund University, Sweden
    Exp Mol Pathol 75:248-55. 2003
    A preformed gelatin matrix containing adherent rat colon carcinoma cells was transplanted subcutaneously into rats to analyze the outgrowth of the tumor and the inflammatory response...
  56. ncbi Low Bloom strength gelatin as a carrier for potential use in retinal sheet encapsulation and transplantation
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomacromolecules 10:310-9. 2009
    ..In the present work, we report the feasibility of applying sandwich-like gelatin membranes as encapsulating carriers for retinal sheet transplantation applications...
  57. ncbi In vitro characterization of chitosan-gelatin scaffolds for tissue engineering
    Yan Huang
    School of Chemical Engineering, Oklahoma State University, 423 Engineering North, Stillwater, OK 74078, USA
    Biomaterials 26:7616-27. 2005
    Recently, chitosan-gelatin scaffolds have gained much attention in various tissue engineering applications...
  58. ncbi Mechanical properties of biomimetic tissue adhesive based on the microbial transglutaminase-catalyzed crosslinking of gelatin
    Martin K McDermott
    Division of Mechanics and Materials Science, Office of Science and Technology, Food and Drug Administration, 9200 Corporate Blvd, HFZ 150, Rockville, Maryland 20850, USA
    Biomacromolecules 5:1270-9. 2004
    ..We are investigating an alternative biomimetic adhesive based on gelatin and a calcium-independent microbial transglutaminase (mTG)...
  59. ncbi Green process to prepare silk fibroin/gelatin biomaterial scaffolds
    Qiang Lu
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    Macromol Biosci 10:289-98. 2010
    ..Silk-based scaffolds are prepared using lyophilization. Gelatin is added to the aqueous silk fibroin solution to change the silk fibroin conformation and silk fibroin-water ..
  60. ncbi Proteome analysis of gelatin-bound urinary proteins from patients with bladder cancers
    Minoru Saito
    Fukuyama Medical Laboratory, Fukuyama, Japan
    Eur Urol 48:865-71. 2005
    ..The aim of the present study is to develop a method of proteomic analysis for urine of patients with bladder cancers...
  61. ncbi Cell delivery using an injectable and adhesive transglutaminase-gelatin gel
    Kenrick Kuwahara
    Department of Biomedical Engineering, USC, Los Angeles, CA 90032, USA
    Tissue Eng Part C Methods 16:609-18. 2010
    In this study, we developed an injectable gelatin-transglutaminase (TGase) gel for cell delivery. The procedure provides a minimally invasive approach to deliver cells into tissue in a manner that improves localization...
  62. ncbi Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione
    Sushma Kommareddy
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
    Bioconjug Chem 16:1423-32. 2005
    To enhance the intracellular delivery potential of plasmid DNA using nonviral vectors, we have developed thiolated gelatin nanoparticles that can release the payload in the highly reducing environment, such as in response to glutathione...
  63. ncbi Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds
    Hae won Kim
    School of Materials Science and Engineering, Seoul National University, Seoul 151 742, Republic of Korea
    Biomaterials 26:5221-30. 2005
    Collagen-derived gelatin/hydroxyapatite (HA) nanocomposites were biomimetically synthesized for hard tissue engineering scaffold...
  64. ncbi Generation of three-dimensional hepatocyte/gelatin structures with rapid prototyping system
    Xiaohong Wang
    Key Laboratory for Advanced Manufacturing by Materials Processing Technology and Center of Organism Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing, China
    Tissue Eng 12:83-90. 2006
    Using rapid prototyping technology, three-dimensional (3D) structures composed of hepatocytes and gelatin hydrogel have been formed...
  65. ncbi Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds
    Hani A Awad
    Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Biomaterials 25:3211-22. 2004
    ..of human adipose-derived adult stem (hADAS) cells seeded in alginate and agarose hydrogels, and porous gelatin scaffolds (Surgifoam), as well as the functional properties of tissue engineered cartilage constructs...
  66. ncbi The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability
    Thomas Billiet
    Polymer Chemistry and Biomaterials Research Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4 bis, Ghent B 9000, Belgium
    Biomaterials 35:49-62. 2014
    ..engineering and biology as a systemic approach for the fabrication of high viability 3D printed macroporous gelatin methacrylamide constructs...
  67. ncbi Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:432-6. 2006
    ..We observed that gelatin-based plasma expanders induced tubular low-molecular-weight proteinuria in healthy volunteers, suggesting that ..
  68. ncbi Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs
    Isotta Chimenti
    Dept of Molecular Medicine, Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University, 00161 Rome, Italy
    Biomaterials 32:9271-81. 2011
    ..Collagen and gelatin are among the most suitable materials used today for CTE approaches...
  69. ncbi Gelatin-nanogold bioconjugates as effective plasmonic platforms for SERS detection and tagging
    Sorina Suarasan
    Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute in Bio Nano Sciences and Faculty of Physics, Babes Bolyai University, M Kogalniceanu 1, 400084 Cluj Napoca, Romania
    Colloids Surf B Biointerfaces 103:475-81. 2013
    ..Specifically, the stability of the AuNPs against salt-induced aggregation was greatly improved in the presence of gelatin biopolymer and stabilization of individual or small assemblies of nanoparticles can be controlled by the amount ..
  70. pmc Brain ethanol levels in rats after voluntary ethanol consumption using a sweetened gelatin vehicle
    J Peris
    Department of Pharmacodynamics, University of Florida, Gainesville FL 32610 USA
    Pharmacol Biochem Behav 85:562-8. 2006
    ..The "jello shot" consists of 10% ethanol in gelatin along with a caloric source (Polycose)...
  71. pmc Gelatin microspheres crosslinked with genipin for local delivery of growth factors
    Luis Solorio
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
    J Tissue Eng Regen Med 4:514-23. 2010
    ..b>Gelatin is a denatured form of collagen that cells can bind to and degrade through enzymatic action...
  72. ncbi Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel
    Ke Cheng
    The Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Biomaterials 33:5317-24. 2012
    ..In situ polymerizable hydrogels made of hyaluronan and porcine gelatin (Hystem(®)-C™) were formulated as a liquid at room temperature so as to gel within 20 min at 37 °C...
  73. ncbi Gelatin nanocarrier enables efficient delivery and phototoxicity of hypocrellin B against a mice tumour model
    Anish Babu
    School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, TN, India
    J Biomed Nanotechnol 8:43-56. 2012
    Nanoparticles formulated from biodegradable and natural polymer gelatin, were investigated for their potential to enable efficient delivery and enhanced efficacy of a well-known photodynamic agent, Hypocrellin B (HB)...
  74. ncbi The role of stiffness of gelatin-hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell
    Li Shan Wang
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore
    Biomaterials 31:8608-16. 2010
    ..The hydrogels were composed of gelatin-hydroxyphenylpropionic acid (Gtn-HPA) conjugate were formed using the oxidative coupling of phenol moieties ..
  75. ncbi Gelatin nanofibrous membrane fabricated by electrospinning of aqueous gelatin solution for guided tissue regeneration
    Shen Zhang
    The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, People s Republic of China
    J Biomed Mater Res A 90:671-9. 2009
    The electrospinning of gelatin aqueous solution was successfully carried out by elevating the spinning temperature...
  76. pmc Characterization of cross-linked porous gelatin carriers and their interaction with corneal endothelium: biopolymer concentration effect
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    PLoS ONE 8:e54058. 2013
    ..of bioengineered corneal endothelial cell (CEC) monolayers allows us to take advantage of cross-linked porous gelatin hydrogels as cell sheet carriers for intraocular delivery...
  77. ncbi Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system
    Z X Meng
    Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin, China
    Colloids Surf B Biointerfaces 84:97-102. 2011
    Drug (Fenbufen, FBF)-loaded poly(D,L-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique...
  78. ncbi Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite
    Chun Hsu Yao
    Department of Radiological Technology, Institute of Biomedical Engineering and Material Science, Chung Tai Institute of Health Science and Technology, Takun, Taichung, Taiwan
    Biomaterials 26:3065-74. 2005
    A biodegradable composite which was composed of genipin cross-linked gelatin mixing with tricalcium phosphate ceramic particles (GGT) was developed as a bone substitute...
  79. ncbi Macroporous interpenetrating cryogel network of poly(acrylonitrile) and gelatin for biomedical applications
    Era Jain
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India
    J Mater Sci Mater Med 20:S173-9. 2009
    ..In the following work we have synthesized full interpenetrating network of polyacrylonitrile (PAN)-gelatin with varied gelatin concentration...
  80. ncbi Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element
    Andrew P Golden
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Lab Chip 7:720-5. 2007
    ..In this procedure, micromolded meshes of gelatin served as sacrificial materials...
  81. ncbi Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair
    Hiroyuki Kobayashi
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 5011194, Japan
    Cardiovasc Res 79:611-20. 2008
    We investigated the effect of an erythropoietin (EPO)-gelatin hydrogel drug delivery system (DDS) applied to the heart on myocardial infarct (MI) size, left ventricular (LV) remodelling and function.
  82. ncbi Study on gelatin-containing artificial skin IV: A comparative study on the effect of antibiotic and EGF on cell proliferation during epidermal healing
    S R Hong
    School of Chemical Engineering, Department of Biomedical Engineering, College of Engineering, Hanyang University, Seoul, South Korea
    Biomaterials 22:2777-83. 2001
    b>Gelatin-hyaluronate sponge with and without antibiotic and epidermal growth factor (EGF) were prepared and compared. Four types of sponges were applied on the full-thickness dorsal skin defect of Wistar rat...
  83. ncbi Bioactive and degradable hybridized nanofibers of gelatin-siloxane for bone regeneration
    Ju Ha Song
    School of Materials Science and Engineering, Seoul National University, Seoul 151 742, Korea
    J Biomed Mater Res A 84:875-84. 2008
    Organic-inorganic hybridized nanofibers constituted of gelatin and siloxane were generated by the electrospinning technique for use as bone regeneration matrices...
  84. ncbi Gelatin-derived bioadhesives for closing skin wounds: an in vivo study
    H W Sung
    Department of Chemical Engineering, National Central University, Chung Li, Taiwan, ROC
    J Biomater Sci Polym Ed 10:751-71. 1999
    Bioadhesives have been used in surgery as hemostatic and wound healing agents. GRF (gelatin + resorcinol + formaldehyde) glue, composed of a mixture of gelatin and resorcinol polymerized by the addition of formaldehyde, has been used for ..
  85. ncbi Development of porous chitosan-gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applications
    C Isikli
    Department of Biomedical Engineering, Middle East Technical University, Ankara, Turkey
    J Tissue Eng Regen Med 6:135-43. 2012
    ..Although there are various natural polymers available for this purpose, chitosan (C) and gelatin (G) are commonly studied because of their inherent properties...
  86. ncbi Poly(Glycerol sebacate)/gelatin core/shell fibrous structure for regeneration of myocardial infarction
    Rajeswari Ravichandran
    Healthcare and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore, Singapore
    Tissue Eng Part A 17:1363-73. 2011
    ..The present study was to fabricate poly (glycerol sebacate)/gelatin (PGS/gelatin) core/shell fibers and gelatin fibers alone by electrospinning for cardiac tissue engineering...
  87. ncbi Increased matrix synthesis by fibroblasts with decreased proliferation on synthetic chitosan-gelatin porous structures
    Pooja Iyer
    School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Biotechnol Bioeng 109:1314-25. 2012
    ..We used chitosan alone and in combination with gelatin. Injectable hydrogels were prepared using 2-glycerol phosphate...
  88. ncbi In vitro and in vivo release of vascular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds
    Zarana S Patel
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Pharm Res 25:2370-8. 2008
    This work evaluated gelatin microparticles and biodegradable composite scaffolds for the controlled release of vascular endothelial growth factor (VEGF) in vitro and in vivo.
  89. ncbi Micropatterning and characterization of electrospun poly(ε-caprolactone)/gelatin nanofiber tissue scaffolds by femtosecond laser ablation for tissue engineering applications
    Yong Chae Lim
    Laboratory for Multiscale Processing and Characterization, The Ohio State University, 1248 Arthur E Adams Dr, Columbus, Ohio 43210, USA
    Biotechnol Bioeng 108:116-26. 2011
    ..of femtosecond (FS) laser ablation for creating microscale features on electrospun poly(ε-caprolactone) (PCL)/gelatin nanofiber tissue scaffold capable of controlling cell distribution are described...
  90. ncbi Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications
    Tianhong Chen
    Center for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, MD 20742, USA
    Biomaterials 24:2831-41. 2003
    We compared the ability of two enzymes to catalyze the formation of gels from solutions of gelatin and chitosan...
  91. pmc Understanding the molecular basis for differential binding of integrins to collagen and gelatin
    Muhammad H Zaman
    Biophys J 92:L17-9. 2007
    ..the molecular specificity, which increases integrin adhesion to native collagen but results in poor integrin-gelatin interaction, is not understood...
  92. ncbi Porous gelatin hydrogels: 1. Cryogenic formation and structure analysis
    Sandra Van Vlierberghe
    Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, Building S4 Bis, B 9000 Ghent, Belgium
    Biomacromolecules 8:331-7. 2007
    In the present work, porous gelatin scaffolds were prepared by cryogenic treatment of a chemically cross-linked gelatin hydrogel, followed by removal of the ice crystals formed through lyophilization...
  93. ncbi A genipin-crosslinked gelatin membrane as wound-dressing material: in vitro and in vivo studies
    Wen Hsiang Chang
    Department of Chemical Engineering National Tsing Hua University, Hsinchu, Taiwan 30013, ROC
    J Biomater Sci Polym Ed 14:481-95. 2003
    A naturally occurring crosslinking agent (genipin) was used in this study to crosslink gelatin hydrogel to develop a wound-dressing membrane...
  94. ncbi Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles
    Dennis P Link
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 29:675-82. 2008
    This study focused at the potential of transforming growth factor beta 1 (TGF-beta 1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (..
  95. ncbi Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    A Schramko
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki HUS, Finland
    Br J Anaesth 104:691-7. 2010
    ..Cardiac surgical patients have an increased risk of bleeding. Both hydroxyethylstarch (HES) and gelatin solutions impair haemostasis. We examined the impact and dose effect on coagulation of HES 130/0...
  96. ncbi Study of novel chitosan-gelatin artificial skin in vitro
    Jinshu Mao
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, Peoples Republic of China
    J Biomed Mater Res A 64:301-8. 2003
    A novel absorbable scaffold composed of chitosan and gelatin was fabricated by freezing and lyophilizing methods, resulting in an asymmetric structure. This bilaminar texture is suitable for preparing a bilayer skin substitute...
  97. ncbi In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor
    Shao Hong Li
    Key Laboratory for Biomechanical and Tissue Engineering, State Ministry of Education, College of Bioengineerin, Chongqing University, Chongqing 400030, China
    Acta Pharmacol Sin 27:754-9. 2006
    ..With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time...
  98. ncbi Effects on coagulation of balanced (130/0.42) and non-balanced (130/0.4) hydroxyethyl starch or gelatin compared with balanced Ringer's solution: an in vitro study using two different viscoelastic coagulation tests ROTEMTM and SONOCLOTTM
    M Casutt
    Institute of Anesthesiology and Intensive Care, Kantonsspital Lucerne, Lucerne, Switzerland
    Br J Anaesth 105:273-81. 2010
    ..42 solution (HES(BAL)), a saline-based 6% HES 130/0.4 solution (HES(SAL)), a balanced lactated Ringer's solution (RL) and a saline-based 4% gelatin solution (GEL).
  99. ncbi Adrenomedullin gene transfer induces therapeutic angiogenesis in a rabbit model of chronic hind limb ischemia: benefits of a novel nonviral vector, gelatin
    Noriyuki Tokunaga
    Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Osaka, Japan
    Circulation 109:526-31. 2004
    ..However, whether AM has angiogenic potential remains unknown. This study investigated whether AM gene transfer induces therapeutic angiogenesis in chronic hind limb ischemia...
  100. ncbi Nanofibrous poly(acrylonitrile-co-maleic acid) membranes functionalized with gelatin and chitosan for lipase immobilization
    Peng Ye
    Institute of Polymer Science, Zhejiang University, Hangzhou 310027, PR China
    Biomaterials 27:4169-76. 2006
    ..Two natural macromolecules, chitosan and gelatin, were tethered on these nanofibrous membranes to fabricate dual-layer biomimetic supports for enzyme ..
  101. ncbi Gelatin based microfluidic devices for cell culture
    A Paguirigan
    Engineering Centers Bldg, 1550 Engineering Dr, Madison, WI 53704, USA
    Lab Chip 6:407-13. 2006
    We have developed a technique for fabricating microfluidic devices from gelatin using a natural crosslinking process...

Research Grants62

  1. IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERING
    Antonios Mikos; Fiscal Year: 2002
    ..Additional components of an injectable formulation will include gelatin porogen, a radical polymerization initiator, and an accelerator...
  2. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..Next, the motility of B. burgdorferi will be examined in gelatin matrices, in order to quantify motility through a controllable model system that mimics the ECM...
  3. Recombinant Polymers for Transarterial Chemoembolization of Liver Cancer
    AZADEH POURSAID; Fiscal Year: 2013
    ..presently approved product, Lipiodol, is an oily emulsion mixed with a chemotherapeutic used in conjunction with gelatin particles or synthetic polymer beads that act as emboli...
  4. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..The drug has been approved by the Food and Drug Administration (FDA) (Marinol(r) soft gelatin capsules) for the treatment of nausea and vomiting associated with chemotherapy and for appetite stimulation in ..
  5. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2011
    ..These samples include tissue phantoms based on gelatin embedded micro spheres covering a USAF 1951 target, onion skin, and tadpole...
  6. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2012
    ..These samples include tissue phantoms based on gelatin embedded micro spheres covering a USAF 1951 target, onion skin, and tadpole...
  7. Injectable Anabolic Biomaterials for Bone Regeneration
    LAKSHMI SREEDHARAN NAIR; Fiscal Year: 2013
    ..Cell culture conditions that are known to induce cellular apoptosis will be used. An injectable gelatin gel will be used as a control matrix to evaluate the efficacy of lactoferrin gel microenvironment in improving ..
  8. Fibronectin Binding MSCRAMMs
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..Many MSCRAMMs bind to multiple domains in Fn. The Gelatin Binding Domain (GBD) is targeted by several microbial proteins...
  9. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..This approach is based on the physical and coagulation properties of a mixture of Teleostan Gelatin type A, Polyvinylpyrrolidone, Sucrose and Fibrinogen, with a water-soluble foam inducer; the addition of thrombin ..
  10. Brain-targeted nanomedicine via buccal administration
    Hu Yang; Fiscal Year: 2010
    ..of brain-targeted dendrimer nanoparticles across the BBB in vitro;Aim 3: Formulate a mucoadhesive PEG/gelatin IPN hydrogel for buccal administration of brain-targeted dendrimer nanoparticles, and determine the controlled ..
  11. Rapid release paclitaxel nanoparticles for bladder cancer intravestical therapy
    Ze Lu; Fiscal Year: 2009
    ..During the Phase I SBIR grant, we evaluated several drug carriers and identified paclitaxel-loaded gelatin nanoparticles (PNP) as the candidate...
  12. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
    ..b>Gelatin will be modified similar to rhLF to form cross-linked gels, which will serve as the control biomaterial in these ..
  13. Driving tissue formation by inductive stem cell sheet technology
    Eben Alsberg; Fiscal Year: 2013
    ..b>Gelatin is used as the base biomaterial for the microspheres, as it forms biocompatible, biodegradable hydrogels that can ..
  14. Biodegradable, hyaluronic acid-based microcarriers for mesenchymal stem cell prop
    ISAAC EDWARD ERICKSON; Fiscal Year: 2011
    ..In our first and second aims, we will synthesize recombinant thiol-modified human gelatin (rhGelin-S) and optimize the matrix composition for performance in a stirred flask bioreactor...
  15. Soft Hydrogels for Expansion of Quiescent Human MSCs
    Sarah Atzet; Fiscal Year: 2010
    ..We will compare MP-attached gels with the gelatin-containing HyStem-C hydrogel to identify conditions that maintain quiescence of mesenchymal stem cell (MSC) and ..
  16. Development of Experimental and Computational Models for Traumatic Aortic Rupture
    Kurosh Darvish; Fiscal Year: 2009
    ..The lungs will be represented by compressible foams and the rest of the space will be filled 10% gelatin and saline to hold the specimen in place...
  17. Hemorrhage Control During Brain Surgery
    Weiliam Chen; Fiscal Year: 2010
    ..for bleeding control during brain surgery has practically not changed for many decades, with oxidized cellulose, gelatin and collagen as the commonly used materials;thrombin is often deployed in conjunction with these materials to ..
  18. Synthetic Scaffolds for Bladder Regeneration
    Sundararajan Madihally; Fiscal Year: 2009
    ..properties using synthetic polymers while the biological response will be regulated by natural polymers such as gelatin. For this purpose, scaffolds of two distinct configurations with amorphous 50:50 poly-lactide- co-glycolide (PLGA)..
  19. MICROFABRICATED 3D VASCULARIZED CARDIAC TISSUE CONSTRUCTS
    Mehdi Nikkhah; Fiscal Year: 2013
    ..We will primarily use natural-based photocrosslinkable hydrogels (gelatin methacrylate, GelMA) to develop highly organized 3D vascularized networks...
  20. MINIR-II: Minimally Invasive Neurosurgical Intracranial Robot
    J Marc Simard; Fiscal Year: 2013
    ..for accurate targeting and resection of the tumor, and finally 4) the safety and efficacy of MINIR-II in gelatin phantoms and clinically relevant models of metastatic brain tumor including, a cadaveric pig model, a live pig ..
  21. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..SCC9/PTF co-cultures organized a rich FN matrix, which was decreased in SCC9beta6/PTF co-cultures. Gelatin zymographs indicated SCC9 and SCC9beta6 cells expressed equivalent levels of matrix metalloproteinases MMP2 and ..
  22. A Novel Biomimetic Bone Cement For Immediately Loaded Dental Implants
    DAVID ALLEN GAUL; Fiscal Year: 2010
    ..We have developed a sol gel modified biomimetic hydroxyapatite-gelatin nano- composite, called GEMOSIL, that has great potential to be a bone cement that can permit the immediate ..
  23. Mast Cell-Mediated Intestinal Permeability
    Katherine Groschwitz; Fiscal Year: 2010
    ..We will perform gelatin zymography to examine the role of mMCP-4 in intestinal MMP-9 activation...
  24. PillStream: Agile High-Throughput Assembly of Custom Multi-Medication Packaging
    EDWARD ACWORTH; Fiscal Year: 2013
    ..9% placement accuracy for surrogate pills and gelatin capsules while exceeding our target fill rate (100 blisters/min) by 50%. Specific Aims...
  25. Designing Optimal Microbicide Delivery Integrating Rheology and Acceptability
    GREGORY RAY ZIEGLER; Fiscal Year: 2012
    ..These products will be an adaptation of current softgel capsule technology. However, unlike current gelatin capsules, we will develop a range of non-gelatin capsules varying in shape and firmness (texture)...
  26. INDUCTION OF DE NOVO DENTAL PAPILLAE FROM YOUNG RODENT
    Mina Mina; Fiscal Year: 2001
    ..from early odotogenic epithelium; 2) to examine the response of in vitro expanded pulp fibroblasts grown within gelatin sponges to the inductive signals from odontogenic epithelium; and 3) to determine whether growth factors can ..
  27. Safe Flexible Intracerebral Navigation with Steerable Needles
    Cameron N Riviere; Fiscal Year: 2012
    ..Preliminary testing of the system has been performed in vitro in a gelatin substrate and in human cadavers...
  28. Designing Optimal Microbicide Delivery Integrating Rheology and Acceptability
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..These products will be an adaptation of current softgel capsule technology. However, unlike current gelatin capsules, we will develop a range of non-gelatin capsules varying in shape and firmness (texture)...
  29. Microengineered Osteoinductive and Vasculogenic Scaffold
    Esmaiel Jabbari; Fiscal Year: 2013
    ..In Aim 1.3, we will synthesize a gelatin-based GelMA hydrogel as a permissive matrix to support vasculogenic differentiation and maturation of bone marrow ..
  30. 92K-GL (MMP 9) AND THE INVASIVE PHENOTYPE
    MARTIN BODDEN; Fiscal Year: 1999
    ..MMP-l,-2, -3, -9, TIMP-l and TIMP-2, on the dissolution of type I collagen, type IV collagen, denatured collagen (gelatin), and a synthetic peptide substrate will be examined...
  31. Raman Markers of Allograft Osseointegration
    MICHAEL DAVID MORRIS; Fiscal Year: 2012
    ..Phantoms will contain gelatin (matrix surrogate), hydroxyapatite (mineral surrogate), lipids, and light absorbing molecules to model both ..
  32. Adolescent Alcohol Exposure and Risky Decision-Making
    Nicholas Nasrallah; Fiscal Year: 2009
    ..of rats do not freely consume significant amounts of alcohol in solution, these studies will employ an ethanol gelatin preparation that has been shown to yield high levels of intake...
  33. AMPLIFIED IMMUNOASSAY OF BACTERIA AND RECOVERY
    SAGYPASH SADIEV; Fiscal Year: 1999
    ..After measurement, these bound bacteria will be eluted using fluoresceyl gelatin or fluoresceyl casein, counted by quantitative PCR and tested for their viability...
  34. GENETIC STUDY OF PROTEASES IN BACTEROIDES GINGIVALIS
    Jeffrey Felton; Fiscal Year: 1991
    ..In addition. overlays of gelatin, casein, or other non-specific substrates will be employed to detect a variety of proteases, and the cloned ..
  35. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..mice, rats, cats, and dogs following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules showed favorable pharmacokinetics...
  36. Ethyl Nitrite and Subarachnoid Hemorrhage
    Huaxin Sheng; Fiscal Year: 2009
    ..g. motor, sensory, and reflexes), rotarod performance, learning set Morris water maze testing, ink-gelatin vascular casting and brain histopathology...
  37. MECHANISMS OF RADIATION SUPPRESSED CORNEAL ANGIOGENESIS
    MARK SCROGGS; Fiscal Year: 1991
    ..Four days after injury, rats will be sacrificed and the vasculature will be immediately perfused with gelatin containing colloidal carbon...
  38. NMR Studies of Plasminogen and Related Genomic Domains
    Miguel Llinas; Fiscal Year: 2004
    ..Implicated in tissue remodeling is the matrix metalloproteinase 2, which digests denatured collagen (gelatin) via adhesion through three fibronectin type II domains...
  39. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..prepare microparticles of the bioerodible poly(d,l-lactide-co-glycolide) (PLGA), including therein both GTF and gelatin as a bioadhesive, for nasal administration...
  40. ECM MATRIX, PROTEASE AND MELANOMA PROLIFERATION
    Yves DeClerck; Fiscal Year: 2007
    ..In contrast, in the presence of denatured, non-fibrillar collagen (gelatin), p27KIP1 is down-regulated, cells spread, the focal adhesion kinase protein p125 FAK is phosphorylated, and ..
  41. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..in mice, dogs, and cats following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules...
  42. INTRA-ARTICULAR DELIVERY OF PEPTIDES AND PROTEINS
    Paul Simpson; Fiscal Year: 1999
    ..Initial studies have demonstrated that microspheres formed by complex coacervation from chondroitin sulfate and gelatin can efficiently encapsulate and release model proteins...
  43. STRUCTURE-FUNCTION STUDIES OF HUMAN PLASMA FIBRONECTIN
    Robert Smith; Fiscal Year: 1990
    ..of the ligand-binding high molecular weight glycoprotein fibronectin (FN) and fragments of denatured collagen (gelatin). Of particular interest are the effects of heparin on the FN fragment-gelatin fragment interactions...
  44. A Biodegradable Doxorubicin Conjugate for Enhanced Tumor Uptake and Efficacy
    CLYDE OFNER; Fiscal Year: 2009
    ..Specific aim one is to develop and characterize a soluble macromolecular conjugate composed of a gelatin carrier at different molecular weights covalently linked to doxorubicin HCl (DOX) by an acid labile hydrazone ..
  45. Protease Inhibitor Related Adipogenesis in HIV Infection
    Krishna Agrawal; Fiscal Year: 2003
    ..by SDS-PAGE electrophoresis and the activation of ECM degrading proteolytic enzymes (MMPs) will be monitored by gelatin zymography...
  46. Bubble Based Acoustic Force Elasticity for Presbyopia
    KYLE HOLLMAN; Fiscal Year: 2006
    ..First we will study physical functional relationships by measuring bubble motion in gelatin phantoms with known elastic and viscoelastic properties...
  47. T CELLS AND IMMUNITY TO CRYPTOCOCCOSIS
    JUNEANN MURPHY; Fiscal Year: 2003
    ..We have developed a murine model in which we implant gelatin sponges into immunized mice, and once the immune response is established then we inject the sponges with either ..
  48. IMAGING OF THREE-DIMENSIONAL DOSE DISTRIBUTIONS NMR
    Robert Schulz; Fiscal Year: 1990
    ..In preliminary trials, gelatin prepared with Fricke dosimeter solution was irradiated by high-energy x rays...
  49. tPA plus MMP inhibition for combination stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..DQ-FITC-gelatin will be infused into the cranial windows, then in vivo 2-photon imaging will be used to mapneurovascular MMP ..
  50. ADVANCES IN DNA VACCINES AGAINST EBOLA & DENGUE VIRUSES
    J August; Fiscal Year: 2001
    ..2) A non-viral system for the in vivo delivery of genes as a DNA-gelatin nanosphere coacervate as a means to deliver the DNA vaccine to antigen presenting cells and for the co-delivery ..
  51. Novel Device with Hemostatic Injection System to Control Post Biopsy Bleeding
    Philip Wong; Fiscal Year: 2009
    ..The device with be bench tested in clear gelatin and subsequently in slaughterhouse porcine kidneys to verify proper deployment of the biopsy needle and ..
  52. MMP1 & MMP9: Mechanism of Activation & Substrate Binding
    Gregory Goldberg; Fiscal Year: 2009
    ..Binding of pro-MMP-9 to gelatin or type IV collagen substrates is sufficient for the enzyme to acquire partial activity with its pro-peptide ..
  53. Modified Hyaluronic Acid for Extrasynovial Tendon Graft
    Chunfeng Zhao; Fiscal Year: 2006
    ..We have found that carbodiimide derivatization of HA (cd-HA) gelatin enhances the binding ability of HA to the tendon surface, decreases the friction, and increase the half-life of ..
  54. CELL CONTACT INDUCED DRUG RESISTANCE
    Marilyn Cornwell; Fiscal Year: 1999
    ..molecular determinants of the multicellular contact effect, we have used a novel II culture model (macroporous gelatin microcarriers, or CultiSphers)...
  55. REGULATION OF GROWTH AND DIFFERENTIATION BY RETINOIDS
    Richard Niles; Fiscal Year: 1990
    ..F9 cells grown on either gelatin or laminin-coated dishes can be induced to differentiate into parietal endoderm-like cells by cholera toxin + 1-..
  56. STRATEGIES TO IMPROVE AAV CFTR PERSISTENCE & EXPRESSION
    Terence Flotte; Fiscal Year: 1999
    ..We plan to make use of a novel non-viral delivery system, gelatin bead complexes, which are capable of incorporating both AAV-vector DNA sequences and Rep protein molecules in a ..
  57. CANDIDATE GENE FOR DIABETIC NEPHROPATHY--MEPRIN BETA
    JUDITH BOND; Fiscal Year: 2002
    ..proteins, including glucagon, insulin B chain, parathyroid hormone, gastrin, cholecystokinin, protein kinase A, gelatin, and collagen...
  58. MECHANISMS TO ENHANCE CYTOLYTIC T CELL RESPONSES TO HIV
    J August; Fiscal Year: 1999
    ..2) A non-viral system for in vivo delivery of genes as a DNA-gelatin nanosphere coacervate is being applied for the delivery of the DNA vaccine to antigen-presenting cells, and for ..
  59. Molecular probing for the mechanism of neuropathic pain
    Ichiro Nishimura; Fiscal Year: 2006
    ..proposes to develop a novel non-invasive gene transfer to sensory neurons using a biocompatible cationized gelatin (CG) vector complexed with plasmid DMA...
  60. SURGICAL ADHESIVE FOR JOINING AND HEALING MOIST TISSUE
    Michael Wilson; Fiscal Year: 2001
    ..The material will overcome the problems of low-strength adhesion exhibited by currently available gelatin and fibrin surgical adhesives...
  61. Crosslinkable Hydrogels for Growth Factor Release
    ROBERT PEATTIE; Fiscal Year: 2005
    ..of the time course of release of sequestered GFs, will be fabricated from chemically modified HA, or HA and gelatin (Gtn)...
  62. A Test of Iron Malabsorption in Patients with IDA
    Morteza Janghorbani; Fiscal Year: 2005
    ..The modification involves ingesting a gelatin capsule at bedtime that contains small quantities of Fe labeled with a non-radioactive (stable) isotope (Fe ), ..