angiotensinogen

Summary

Summary: An alpha-globulin of which a fragment of 14 amino acids is converted by renin to angiotensin I, the inactive precursor of angiotensin II. It is a member of the serpin superfamily.

Top Publications

  1. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
  2. pmc Urinary angiotensinogen as a novel early biomarker of intrarenal renin-angiotensin system activation in experimental type 1 diabetes
    Masumi Kamiyama
    Department of Physiology, Tulane University Health Sciences Center, USA
    J Pharmacol Sci 119:314-23. 2012
  3. pmc Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Kidney Int 61:579-85. 2002
  4. pmc Liver angiotensinogen is the primary source of renal angiotensin II
    Taiji Matsusaka
    Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Am Soc Nephrol 23:1181-9. 2012
  5. pmc Urinary angiotensinogen and risk of severe AKI
    Joseph L Alge
    Medical University of South Carolina, Charleston, SC 29425, USA
    Clin J Am Soc Nephrol 8:184-93. 2013
  6. ncbi Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis
    Lin dan Ji
    Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou, PR China
    J Hypertens 28:419-28. 2010
  7. ncbi Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice
    M L Brezniceanu
    Research Centre, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, Quebec, Canada
    Kidney Int 71:912-23. 2007
  8. pmc A redox switch in angiotensinogen modulates angiotensin release
    Aiwu Zhou
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Nature 468:108-11. 2010
  9. ncbi Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Department of Internal Medical, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Endocrinol Metab 286:E891-5. 2004
  10. ncbi Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Am J Hypertens 10:921-8. 1997

Detail Information

Publications316 found, 100 shown here

  1. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
    ..Proximal tubular angiotensinogen, collecting duct renin, and tubular angiotensin II type 1 (AT1) receptors are positively augmented by ..
  2. pmc Urinary angiotensinogen as a novel early biomarker of intrarenal renin-angiotensin system activation in experimental type 1 diabetes
    Masumi Kamiyama
    Department of Physiology, Tulane University Health Sciences Center, USA
    J Pharmacol Sci 119:314-23. 2012
    ..This study was performed to investigate whether urinary angiotensinogen (UAGT) level may serve as a useful marker of the early stage of experimental type 1 diabetes (T1DM)...
  3. pmc Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Kidney Int 61:579-85. 2002
    In rats maintained on a high salt diet (H/S) to suppress basal renal angiotensinogen levels, angiotensin II (Ang II) infusion for 13 days increased renal angiotensinogen mRNA and protein, thus providing a mechanism for further ..
  4. pmc Liver angiotensinogen is the primary source of renal angiotensin II
    Taiji Matsusaka
    Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Am Soc Nephrol 23:1181-9. 2012
    ..Because the kidney abundantly expresses angiotensinogen mRNA, transcriptional dysregulation of angiotensinogen within the kidney is one potential cause of increased ..
  5. pmc Urinary angiotensinogen and risk of severe AKI
    Joseph L Alge
    Medical University of South Carolina, Charleston, SC 29425, USA
    Clin J Am Soc Nephrol 8:184-93. 2013
    ..Biomarkers of AKI that can predict which patients will develop severe renal disease at the time of diagnosis will facilitate timely intervention in populations at risk of adverse outcomes...
  6. ncbi Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis
    Lin dan Ji
    Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou, PR China
    J Hypertens 28:419-28. 2010
    The polymorphisms of angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes have been linked to increased risk of essential hypertension in multiple populations, but the results were inconsistent.
  7. ncbi Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice
    M L Brezniceanu
    Research Centre, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, Quebec, Canada
    Kidney Int 71:912-23. 2007
    ..Hyperglycemic conditions increase oxidative stress and angiotensinogen gene expression...
  8. pmc A redox switch in angiotensinogen modulates angiotensin release
    Aiwu Zhou
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Nature 468:108-11. 2010
    ..by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease inhibitors...
  9. ncbi Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Department of Internal Medical, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Endocrinol Metab 286:E891-5. 2004
    Adipose tissue represents an important source of angiotensinogen (AGT)...
  10. ncbi Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy
    Y Yamada
    Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Am J Hypertens 10:921-8. 1997
    ..An allelic association study for the angiotensin converting enzyme (ACE) and angiotensinogen genes has now been performed with 71 patients with nonfamilial HCM, 88 patients with nonfamilial DCM, and 122 ..
  11. pmc Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice
    Frederique Yiannikouris
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Hypertension 60:1524-30. 2012
    ..Adipocytes express angiotensinogen and secrete angiotensin peptides...
  12. pmc Multiphoton imaging of the glomerular permeability of angiotensinogen
    Daisuke Nakano
    Department of Pharmacology, Kagawa University, Kagawa, Japan
    J Am Soc Nephrol 23:1847-56. 2012
    Patients and animals with renal injury exhibit increased urinary excretion of angiotensinogen. Although increased tubular synthesis of angiotensinogen contributes to the increased excretion, we do not know to what degree glomerular ..
  13. pmc Divergent localization of angiotensinogen mRNA and protein in proximal tubule segments of normal rat kidney
    Masumi Kamiyama
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Hypertens 30:2365-72. 2012
    b>Angiotensinogen in the kidneys is formed primarily in the proximal tubule cells and is secreted into the tubular fluid. Structurally, proximal tubules can be divided into three segments...
  14. pmc Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients
    Hiroyuki Kobori
    Department of Medicine, Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    Hypertension 53:344-50. 2009
    We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index of the intrarenal renin-angiotensin system (RAS) status in angiotensin II-dependent hypertensive rats...
  15. ncbi Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms
    E Poch
    Nephrology Department, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Hypertension 38:1204-9. 2001
    ..The polymorphisms evaluated correspond to the following genes: ACE (I/D), angiotensinogen (M235T), angiotensin II type 1 receptor (A1166C), 11beta-Hydroxysteroid dehydrogenase type 2 (11betaHSD2) (..
  16. pmc The renin-angiotensin system and diabetes: an update
    Antônio Ribeiro-Oliveira
    Laboratorio de Endocrinologia, Departamento de Clinica Medica, Centro Universitário de Belo Horizonte, UNIBH, Belo Horizonte, MG, Brazil
    Vasc Health Risk Manag 4:787-803. 2008
    ....
  17. ncbi The angiotensinogen gene 235T variant is associated with an increased risk of restenosis after percutaneous transluminal coronary angioplasty
    H Volzke
    Clinic of Internal Medicine B, Ernst Moritz Arndt University, Greifswald, Germany
    Clin Sci (Lond) 99:19-25. 2000
    ..In the present study, we investigated the associations between the angiotensinogen T174M and M235T, the angiotensin I-converting enzyme (ACE) I/D and the angiotensin II type 1 receptor A1166C ..
  18. ncbi Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance
    Nishan S Kalupahana
    Obesity Research Center, University of Tennessee UT, Knoxville, Tennessee, USA
    Obesity (Silver Spring) 20:48-56. 2012
    ..We tested the hypothesis that overexpression of angiotensinogen (Agt) from WAT causes systemic insulin resistance via modulation of adipose inflammation...
  19. pmc Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells
    Ping Lu
    Department of Geriatrics, 9th People s Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Med Sci Monit 17:BR248-56. 2011
    ..b>Angiotensinogen (AGT) is an important precursor in tissue RAS...
  20. pmc Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese
    Yu Jing Fang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Hypertens 28:1203-9. 2010
    The angiotensinogen gene has been linked with human essential hypertension in whites but the relationship in Asian populations has been less consistent...
  21. ncbi Genetic basis of hypertension: revisiting angiotensinogen
    Matthew E Dickson
    Medical Scientist Training Program and Genetics Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 48:14-20. 2006
  22. pmc Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species--ERK/JNK pathways
    Naro Ohashi
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertens Res 33:1174-81. 2010
    Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pathological conditions...
  23. ncbi Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes
    Agnieszka Biala
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Blood Press 19:196-205. 2010
    ..Four-week-old double transgenic rats harboring human renin and human angiotensinogen genes (dTGR) were treated for 4 weeks either with SIRT1 activator resveratrol or SIRT1 inhibitor nicotinamide...
  24. pmc Regulation of intrarenal angiotensin II in hypertension
    L Gabriel Navar
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hypertension 39:316-22. 2002
    ..The enhanced intrarenal Ang II also exerts a positive feedback action to augment intrarenal levels of angiotensinogen (AGT) mRNA and protein, which contribute further to the increased intrarenal Ang II in hypertensive states...
  25. ncbi Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
    F Massiera
    CNRS UMR 6543, Institute of Signaling, Development and Cancer, Nice, France
    FASEB J 15:2727-9. 2001
    White adipose tissue and liver are important angiotensinogen (AGT) production sites. Until now, plasma AGT was considered to be a reflection of hepatic production...
  26. ncbi Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
    ..gene insertion/deletion (I/D) polymorphism; T174M, M235T, G-6A, A-20C, G-152A and G-217A polymorphisms of the angiotensinogen gene; and A1166C polymorphism of the angiotensin II type I receptor gene were genotyped...
  27. ncbi Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
    Tiago Veiga Pereira
    Heart Institute InCor, Faculty of Pharmaceutical Sciences, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Hypertension 51:778-83. 2008
    b>Angiotensinogen (AGT) gene polymorphisms have been linked to increased risk of hypertension, but the data remain controversial...
  28. pmc Urinary angiotensinogen as an indicator of intrarenal Angiotensin status in hypertension
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertension 41:42-9. 2003
    Angiotensin II (AngII) infusions augment renal angiotensinogen mRNA and protein and urinary angiotensinogen excretion (U(AGT))...
  29. ncbi Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    T Lau
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetologia 47:240-8. 2004
    ..This study aimed, primarily, to investigate the existence of a local angiotensin-generating system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin secretion...
  30. ncbi The M235T polymorphism of the angiotensinogen gene in South Indian patients of hypertrophic cardiomyopathy
    - Polugari Prem Kumar Manohar Rao
    Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India
    J Renin Angiotensin Aldosterone Syst 12:238-42. 2011
    ..The objective of the present study was to examine the association of the T704C polymorphism of exon 2 of the angiotensinogen (AGT) gene with HCM in a South Indian population from Andhra Pradesh. Subjects and methods...
  31. ncbi The intracellular renin-angiotensin system: a new paradigm
    Rajesh Kumar
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
    Trends Endocrinol Metab 18:208-14. 2007
    ..A more comprehensive understanding of the intracellular RAS provides for new strategies in system regulation and a more efficacious approach to the management of RAS-related diseases...
  32. pmc Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice
    Chao Sheng Lo
    Universite de Montreal, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu Hospital, Pavillon Masson, 3850 St Urbain St, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 302:F840-52. 2012
    ..Ace2) expression, hypertension, and renal proximal tubular cell (RPTC) apoptosis in type 1 diabetic Akita angiotensinogen (Agt)-transgenic (Tg) mice that specifically overexpress Agt in their RPTCs...
  33. ncbi Coronary heart disease, hypertension, and angiotensinogen gene variants in Indian population
    K G Nair
    Research Laboratories, PD Hinduja National Hospital and Medical Research Centre, Mumbai, India
    J Clin Lab Anal 17:141-6. 2003
    ..Two variants of the angiotensinogen (AGT) gene, M235T and T174M, have been shown to be associated with increased risk of hypertension...
  34. ncbi Cardiovascular diseases and molecular variants of the renin-angiotensin system components in Slovak population
    D Jurkovicova
    Institute of Molecular Physiology and Genetics, Centre of Excellence for Cardiovascular Research of Slovak Academy of Sciences, Bratislava, Slovakia
    Gen Physiol Biophys 26:27-32. 2007
    ..We examined frequencies of the M235T variant of angiotensinogen gene and I/D polymorphism of gene for angiotensin-converting enzyme in Slovak population: in hypertensive ..
  35. pmc Overexpression of angiotensinogen increases tubular apoptosis in diabetes
    Fang Liu
    Université de Montréal Centre hospitalier de l Université de Montréal Hôtel Dieu, Research Centre Pavillon Masson, 3850 Saint Urbain Street, Montreal, Quebec, Canada H2W 1T8
    J Am Soc Nephrol 19:269-80. 2008
    ..We have previously reported that mice overexpressing angiotensinogen in renal proximal tubular cells (RPTC) develop hypertension, albuminuria, and renal injury...
  36. ncbi Renal damage inhibited in mice lacking angiotensinogen gene subjected to unilateral ureteral obstruction
    Yasumitsu Uchida
    Department of Urology, Keio University School of Medicine, Tokyo, Japan
    Urology 74:938-43. 2009
    ..II (Ang II) contributes to renal interstitial fibrosis, the inflammatory response, and tubular cell apoptosis and proliferation in unilateral ureteral obstruction using mice genetically deficient in angiotensinogen (Agt(-/-)).
  37. ncbi Association of angiotensinogen (M235T) gene polymorphism with blood pressure lowering response to angiotensin converting enzyme inhibitor (Enalapril)
    Kamna Srivastava
    Molecular Cardiology Lab, Dr B R Ambedkar Centre for Biomedical Research, University of Delhi, India
    J Pharm Pharm Sci 15:399-406. 2012
    ..We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the ..
  38. ncbi Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney
    Mieke van den Heuvel
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 29:2147-55. 2011
    ..To study which renin-angiotensin-aldosterone system (RAAS) component best reflects renal RAAS activity...
  39. ncbi Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells
    Tusty Jiuan Hsieh
    Research Centre, Centre Hospitalier de l Universite de Montreal CHUM, Hotel Dieu, 3850 Saint Urbain Street, Montreal, Quebec H2W 1T8, Canada
    J Endocrinol 183:535-50. 2004
    We reported previously that insulin inhibits the stimulatory effect of high glucose on the expression of angiotensinogen (ANG) gene in both rat immortalized renal proximal tubular cells (IRPTCs) and non-diabetic rat renal proximal ..
  40. pmc Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Nephrol Dial Transplant 26:170-7. 2011
    ..The present study was performed to test the hypothesis that urinary angiotensinogen provides a specific index of intrarenal RAS status in patients with immunoglobulin A (IgA) nephropathy.
  41. ncbi Angiotensinogen gene polymorphism in acute myocardial infarction patients
    Sounira Mehri
    Laboratoire de Biochimie UR Human Nutrition and Metabolic Disorders, Faculte de Medecine, Monastir, Tunisie, Unité de Recherche Epidémiologie Génétique et Moléculaire, Faculte de Medecine de Tunis, Tunisie
    J Renin Angiotensin Aldosterone Syst 12:42-7. 2011
    The objective of the study was to explore the role of a genetic variant of angiotensinogen (AGT), M235T, as an independent risk factor for acute myocardial infarction (AMI) and to investigate the possible association with the severity of ..
  42. pmc Proximal tubule angiotensinogen modulation of arterial pressure
    Nirupama Ramkumar
    Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Curr Opin Nephrol Hypertens 22:32-6. 2013
    ..Several recent studies have shed light on one component of the system, proximal tubule-derived angiotensinogen (AGT). This review discusses the synthesis, regulation and function of AGT in the proximal tubule.
  43. pmc Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy
    Yoshio Konishi
    Division of Nephrology and Hypertension, Osaka City General Hospital, 2 13 22 Miyakojima Hondori, Miyakojima ku, Osaka 534 0021, Japan
    Hypertension 58:205-11. 2011
    ..We also showed that increased urinary angiotensinogen levels in such patients closely correlate with augmented renal tissue angiotensinogen gene expression and ..
  44. ncbi Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians
    N Ranjith
    Department of Medicine and the Coronary Care Unit, R K Khan Hospital, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Cardiovasc J S Afr 15:22-6. 2004
    ..system, such as the angiotensin-converting enzyme (ACE) gene, angiotensin II type 1 (AT1) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects...
  45. ncbi Angiotensinogen polymorphisms and elevated blood pressure in the general population: the Copenhagen City Heart Study
    A A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Hypertension 37:875-81. 2001
    ..Homozygosity for both Thr235 and Thr174 was associated with a 10% increase in plasma angiotensinogen levels in both genders compared with homozygosity for Met235 and Thr174; however, systolic and diastolic ..
  46. pmc Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA
    Hiroyuki Kobori
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 294:F1257-63. 2008
    We recently reported that urinary excretion rates of angiotensinogen provide a specific index of the intrarenal renin-angiotensin system status in angiotensin II-dependent hypertensive rats...
  47. ncbi The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity
    V van Harmelen
    Department of Medicine and Research Center, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Int J Obes Relat Metab Disord 24:673-8. 2000
    To investigate in obese subjects the relationship between angiotensinogen gene expression in the abdominal omental and subcutaneous adipose tissue on the one hand and body fat distribution as measured by waist-to-hip ratio (WHR) on the ..
  48. pmc Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    FASEB J 26:1821-30. 2012
    Renal inflammation modulates angiotensinogen (AGT) production in renal proximal tubular cells (RPTCs) via inflammatory cytokines, including interleukin-6, tumor necrosis factor α, and interferon-γ (IFN-γ)...
  49. ncbi Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension--a case-control study
    Vamsi U Mohana
    Department of Genetics, Osmania University, Hyderabad 500 007, India
    Clin Exp Hypertens 34:38-44. 2012
    The human angiotensinogen (AGT) is a promising candidate gene for evaluating susceptibility to essential hypertension (EH). We aimed to assess the association of the variants of AGT gene and the extent of risk involved in developing EH.
  50. ncbi Association of the angiotensinogen M235T and APO E gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy
    Kadriye Altok Reis
    Department of Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey
    Ren Fail 33:469-74. 2011
    ....
  51. pmc Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma
    L Juillerat-Jeanneret
    University Institute of Pathology, CHUV, Bugnon 25, Lausanne CH1011, Switzerland
    Br J Cancer 90:1059-68. 2004
    ..Renin and angiotensinogen (AGT) mRNAs and proteins were found by in situ hybridisation and immunohistochemistry in glioblastoma cells...
  52. pmc Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease
    G E Hume
    J Med Genet 43:e51. 2006
    ..A variant in the angiotensinogen gene promoter results in increased peptide production, while transforming growth factor beta1 (TGFbeta1) ..
  53. pmc Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study)
    Hiroyuki Kobori
    Hypertension and Renal Center of Excellence, Department of Medicine, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Hypertens 28:1422-8. 2010
    ..Considerable sex and racial differences have been found to be related to cardiovascular disease. Urinary angiotensinogen (UAGT) is a novel biomarker for the intrarenal activity of the renin-angiotensin system in hypertension and ..
  54. ncbi Angiotensinogen gene knockout delays and attenuates cold-induced hypertension
    Zhongjie Sun
    Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0274, USA
    Hypertension 41:322-7. 2003
    ..Two groups of wild-type (WT) mice and 2 groups of angiotensinogen gene knockout (Agt-KO) mice (6 per group) were used...
  55. pmc Oxidative stress/angiotensinogen/renin-angiotensin system axis in patients with diabetic nephropathy
    Masumi Kamiyama
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Int J Mol Sci 14:23045-62. 2013
    ..In rodent models, it has been reported that reactive oxygen species (ROS) are important for intrarenal angiotensinogen (AGT) augmentation in the progression of diabetic nephropathy...
  56. ncbi Concentrations and actions of intraluminal angiotensin II
    L G Navar
    Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Am Soc Nephrol 10:S189-95. 1999
    ..The high intratubular concentrations of AngII, as well as angiotensin I and angiotensinogen, are much greater than can be explained on the basis of delivery via glomerular filtration...
  57. ncbi Endothelial nitric oxide synthase and angiotensinogen gene polymorphism in coronary artery diseases in Egypt
    Tarek Motawi
    Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt
    Angiology 62:191-7. 2011
    ..healthy individuals to assess the association of endothelial nitric oxide (eNOS) polymorphism (Glu298Asp) and angiotensinogen polymorphisms (M235T) and CAD in an Egyptian population...
  58. ncbi Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients
    Georgia Ragia
    Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    J Renin Angiotensin Aldosterone Syst 11:136-45. 2010
    ..We examined the association of polymorphisms of angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT(1) receptor) with severe CAD in CABG patients.
  59. pmc JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts
    Amal Abdul-Hafez
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    FASEB J 23:1655-62. 2009
    Earlier work showed that TGF-beta1 potently increases angiotensinogen (AGT) gene mRNA in primary human lung fibroblasts. Here the mechanism of TGF-beta1-induced AGT expression was studied in the IMR90 human lung fibroblast cell line...
  60. pmc The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2533. 2008
    ..The M235T polymorphism in the AGT gene has been related to an increased risk of hypertension. This finding may also suggest an increased risk of coronary heart disease (CHD)...
  61. ncbi Differential regulation of central vasopressin receptors in transgenic rats with low brain angiotensinogen
    Luciana A Campos
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, Berlin Buch, D 13125, Germany
    Regul Pept 119:177-82. 2004
    ..system (RAS) on central vasopressinergic system was studied in transgenic rats with low brain angiotensinogen [TGR(ASrAOGEN)]...
  62. ncbi Evaluation of the contribution of renin angiotensin system polymorphisms to the risk of coronary artery disease among Tunisians
    Nesrine Abboud
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Genet Test Mol Biomarkers 14:661-6. 2010
    ..between these polymorphisms (angiotensin-converting enzyme [ACE] insertion/deletion [Ins/Del]; the angiotensinogen T174M and M235T; and the angiotensin II type 1 receptor A1166C polymorphisms) and CAD in Tunisians...
  63. pmc Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699, USA
    Hypertension 41:592-7. 2003
    This study was performed to examine whether there is an inappropriate regulation of intrarenal angiotensinogen in Dahl-salt sensitive rats (DS) fed a high salt diet (HS)...
  64. ncbi Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study
    X Jiang
    Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    J Hum Hypertens 23:176-81. 2009
    ..We examined six polymorphisms in the main component genes of RAS: angiotensin-converting enzyme (ACE) (I/D), angiotensinogen (AGT) (A-6G, A-20C, G-217A and T174 M) and angiotensin type 1 receptor (AT1R) (A1166C)...
  65. ncbi Angiotensinogen promoter B-haplotype associated with cerebral small vessel disease enhances basal transcriptional activity
    Helena Schmidt
    Institute of Medical Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria
    Stroke 35:2592-7. 2004
    Previously, we described the presence of 5 haplotypes (A to E) at the angiotensinogen (AGT) promoter and reported a significant association between the B-haplotype (nucleotide substitutions -6:G-->A and -20:A-->C compared with the ..
  66. ncbi Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis
    Igor Medica
    Division of Medical Genetics, Department of Gynecology and Obstetrics, University Clinical Centre, Ljubljana, Slovenia
    Eur J Obstet Gynecol Reprod Biol 131:115-26. 2007
    There are controversies in reports on the association of polymorphisms in endothelial nitric oxide synthase, angiotensinogen, angiotensin receptor type 1 and angiotensin-converting enzyme genes with an increased risk of developing ..
  67. pmc Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain
    Jonathan A Cohen
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1095, USA
    Am J Physiol Renal Physiol 299:F35-42. 2010
    ..Because estrogen and salt influence angiotensinogen (AGT), circulating and renal expression of the protein were assessed in the mRen2 using a sensitive and ..
  68. ncbi Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II
    Ramon Bataller
    Department of Medicine, Hospital Clinic, Institut d Investigacions Biomédiques August Pi y Sunyer, University of Brescia School of Medicine, Barcelona, Catalonia, Spain
    Gastroenterology 125:117-25. 2003
    ..The aim of this study was to investigate whether quiescent and activated human hepatic stellate cells contain the components of the renin-angiotensin system and synthesize angiotensin II...
  69. ncbi STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen
    Sutapa Ray
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 8709, USA
    Gastroenterology 129:1616-32. 2005
    ..transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown...
  70. pmc Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Hypertens 19:541-50. 2006
    ..These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for renin that is the rate-limiting enzyme of the renin-angiotensin system...
  71. pmc Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats
    Kayoko Miyata
    Department of Medicine, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Clin Exp Pharmacol Physiol 35:922-7. 2008
    1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker ..
  72. ncbi The paradox of the low-renin state in diabetic nephropathy
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 10:2382-91. 1999
    ..This increase could account for suppressed circulating renin, the exaggerated renal vasodilator response to irbesartan, and the therapeutic effectiveness of interrupting the renin system in diabetic nephropathy...
  73. pmc Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension
    H Kobori
    Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Am Soc Nephrol 12:431-9. 2001
    ..This study was designed to test the hypothesis that chronic AngII infusion increases renal angiotensinogen mRNA and protein levels, thus contributing to the increase in intrarenal AngII levels...
  74. ncbi Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease
    Tatsuo Yamamoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, Japan
    J Am Soc Nephrol 18:1558-65. 2007
    ..For assessment of the potential of urinary angiotensinogen as a marker of intrarenal AngII activity, the correlation of plasma and urinary renin-angiotensin system ..
  75. pmc Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes
    Toshie Saito
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Am J Med Sci 338:478-80. 2009
    We previously reported that kidney and urinary angiotensinogen levels were significantly increased before the development of diabetic nephropathy in diabetic rats...
  76. pmc Enhanced intrarenal oxidative stress and angiotensinogen in IgA nephropathy patients
    Hiroyuki Kobori
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Biochem Biophys Res Commun 358:156-63. 2007
    This study was performed to determine whether immunoreactivity of intrarenal hemeoxygenase-1 and angiotensinogen are increased in IgA nephropathy (IgAN) patients...
  77. ncbi Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Hypertension 41:50-5. 2003
    ..wall in maximally dilated cerebral arterioles in transgenic mice that overexpress both human renin and human angiotensinogen and in spontaneously hypertensive mice, a model of chronic hypertension that is thought to develop ..
  78. ncbi Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity
    F Massiera
    Centre National de la Recherche Scientifique 6543, Centre de Biochimie, Nice 06108, France
    Endocrinology 142:5220-5. 2001
    ..is known to contain the components of the renin-angiotensin system, which gives rise to angiotensin II from angiotensinogen (AGT)...
  79. ncbi Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue
    Laurent Yvan-Charvet
    Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie, Centre Biomédical des Cordeliers, Paris, France
    Endocrinology 150:1421-8. 2009
    Increased angiotensinogen (AGT) production by white adipose tissue has been related to not only obesity but also hypertension...
  80. pmc 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway
    Dilip K Deb
    Department of Medicine and Committee on Molecular Metabolism and Nutrition, Division of Biological Sciences, The University of Chicago, Chicago, Illinois, USA
    Am J Physiol Renal Physiol 296:F1212-8. 2009
    ..D(3) [1,25(OH)(2)D(3)] plays a renoprotective role by suppressing the RAS, with renin and angiotensinogen (AGT) as the main targets...
  81. ncbi Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II
    C Karlsson
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 83:3925-9. 1998
    ..Angiotensin II is produced by cleavage of angiotensinogen by renin and angiotensin-converting enzyme in the circulation...
  82. pmc Intrarenal oxidative stress and augmented angiotensinogen are precedent to renal injury in Zucker diabetic fatty rats
    Yuki Suzaki
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Int J Biol Sci 3:40-6. 2007
    ..This study was performed to examine the possible involvement of enhanced intrarenal angiotensinogen in the development of renal injury in ZDF rats...
  83. ncbi Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination
    B Cvetkovic
    Molecular Biology Interdisciplinary Program, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 275:1073-8. 2000
    ..In this report, we describe the development of a human angiotensinogen transgenic mouse model generated by targeting the human angiotensinogen gene upstream of the mouse HPRT locus ..
  84. pmc Localisation of renin-angiotensin system (RAS) components in breast
    M Tahmasebi
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Br J Cancer 95:67-74. 2006
    ..1) mRNA coding for angiotensinogen, prorenin, angiotensin converting enzyme (ACE), and both AT1 and AT2 receptors was demonstrated in normal and ..
  85. ncbi Angiotensinogen-deficient mice with hypotension
    K Tanimoto
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Biol Chem 269:31334-7. 1994
    ..II, through its physiologically inactive intermediate decapeptide angiotensin I, from their precursor angiotensinogen. In the present study, we generated angiotensinogen-deficient mice by homologous recombination in mouse ..
  86. pmc Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice
    Hiroyuki Kobori
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 293:F938-45. 2007
    ..to test the hypothesis that the selective intrarenal overproduction of ANG II increases intrarenal mouse (m) angiotensinogen (AGT) expression...
  87. ncbi Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic and Department of Pathology, HELIOS Klinikum Berlin, Germany
    Hypertension 45:742-6. 2005
    We used rats transgenic for the human angiotensinogen (hAogen) gene and the human renin (hRen) gene and crossed the strains to produce a model of preeclampsia in the dams...
  88. ncbi Increased adipose angiotensinogen gene expression in human obesity
    V van Harmelen
    Department of Medicine and Research Center, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Obes Res 8:337-41. 2000
    Adipose angiotensinogen has been suggested as a stimulator of adipose tissue growth and development. Therefore, the association of subcutaneous adipose angiotensinogen gene expression with human obesity was studied.
  89. ncbi Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 15:478-84. 2007
    b>Angiotensinogen is an essential component of the renin-angiotensin system. ACE-inhibitors and beta-blockers both have a direct influence on this system...
  90. ncbi Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy
    Pardeep Kumar Aggarwal
    Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Hypertens Res 33:473-7. 2010
    ..in genes encoding endothelial nitric oxide synthase (NOS3), angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) in hypertensive disorders of pregnancy and the relationship between the polymorphisms and circulating ..
  91. ncbi A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system
    I Inoue
    Howard Hughes Medical Institute, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    J Biol Chem 270:11430-6. 1995
    b>Angiotensinogen exhibits genetic linkage to and association with essential hypertension and preeclampsia, a common hypertensive disorder of pregnancy; however, the polymorphisms detected thus far provide no functional clues...
  92. ncbi Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes
    A L Harte
    Division of Medical Sciences, Department of Medicine, University of Birmingham, Birmingham B15 2TH, UK
    Diabetes Obes Metab 5:462-7. 2003
    ..However, to date no study has investigated the influence of varying insulin concentrations on angiotensinogen (AGT) protein expression in human subcutaneous abdominal fat...
  93. ncbi Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen
    Atsushi Sakima
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 292:H1412-9. 2007
    ..endogenous to NTS on cardiovascular reflex function was investigated in transgenic rats with low brain angiotensinogen (Aogen) due to glial overexpression of an antisense to Aogen (ASrAOGEN) and in Sprague-Dawley (SD) rats...
  94. ncbi Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes
    Juan Carlos Yugar-Toledo
    Laboratory of Cardiovascular Pharmacology, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil
    DNA Cell Biol 30:555-64. 2011
    ..We examined the interaction of angiotensin I-converting enzyme (ACE), angiotensinogen (AGT), and endothelial nitric oxide synthase (NOS3) polymorphisms with environmental factors (gender, age, ..
  95. ncbi Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene
    Yoko Shimamoto
    Center for Tsukuba Advanced Research Alliance, Aspect of Functional Genomic Biology, Institute of Applied Biochemistry, University of Tsukuba, Ten noudai 1 1 1, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 279:7770-6. 2004
    ..In this study, we identified angiotensinogen (ANG), the precursor of vasoactive octapeptide angiotensin II, as a novel target gene of bile acids...
  96. pmc Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin-angiotensin system in the nigra
    Pablo Garrido-Gil
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
    Brain Struct Funct 218:373-88. 2013
    ..However, angiotensinogen and receptors for angiotensin and renin-prorenin were also observed at the cytoplasm and nuclear level, which ..
  97. ncbi ACE and angiotensinogen gene genotypes and left ventricular mass in athletes
    F Diet
    Klinik fur Innere Medizin III, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Eur J Clin Invest 31:836-42. 2001
    ..The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known...
  98. pmc Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats
    Licy L Yanes
    Univ of Mississippi Medical Center, Dept of Physiology and Biophysics, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 296:F771-9. 2009
    ..to the systemic renin-angiotensin system, which is suppressed in response to HS in male DS, intrarenal angiotensinogen expression is increased, and intrarenal levels of ANG II are not suppressed...
  99. ncbi Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study
    L P Svetkey
    Duke Hypertension Center and Sarah W Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Hypertens 19:1949-56. 2001
    To determine the relationship between angiotensinogen (ANG) genotype and blood pressure response to the dietary patterns of the Dietary Approaches to Stop Hypertension (DASH) trial...
  100. ncbi Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging
    Sherry O Kasper
    The Hypertension and Vascular Disease Center and Physiology Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Endocrine 30:167-74. 2006
    ..compared responses to an oral glucose load in transgenic rats with selective antisense suppression of brain angiotensinogen (ASrAogen); (mRen2)27 rats with high brain angiotensin II; and control Hannover Sprague-Dawley (SD) rats, at ..
  101. ncbi The predominant role of brain angiotensinogen and angiotensin in environmentally induced hypertension
    JianFeng Peng
    Department of Pharmacology, University of California, San Diego, Box 0636, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
    Regul Pept 110:25-32. 2002
    ..The goal of the present study was to evaluate the role of central and peripheral circulating RAS components, angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin (Ang) II, in CIH...

Research Grants63

  1. Angiotensin II and NADPH Oxidase in Hepatic Fibrosis
    David Brenner; Fiscal Year: 2009
    ..The underlying hypotheses that serve as the basis for this proposal are the following: 1.The renin-angiotensinogen system is a critical pathway in hepatic fibrosis. 2...
  2. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Common genetic variation in the angiotensinogen (AGT) gene predisposes to essential hypertension (EH) and increased plasma AGT in humans...
  3. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..To test this hypothesis, there transgenic mice models, R+A+ (renin and angiotensinogen over-expression), ACE2+ (ACE2 over-expressed in the brain) and R+A+ACE2+ (ACE2 over-expressed in the brain of ..
  4. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..an alternate precursor of angiotensin peptides in the heart and that its regulation and expression from angiotensinogen critically influences the cellular actions of the cardiac RAS: Proiect 2 investigates the hypothesis that Ang-..
  5. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..In preliminary studies, enalapril decreases BP more in HAF rats than in controls, and angiotensinogen is increased, suggesting that the RAS is upregulated and in part mediates their HT...
  6. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..In particular, studies have shown that adipose-derived angiotensinogen (AGT) can contribute to approximately 20% of plasma AGT concentrations and modulate blood pressure...
  7. Stress-induced hypertension and the role of the neuroimmune system
    PAUL MARVAR; Fiscal Year: 2012
    ..us to specifically identify CRH producing cells in the BNST as well as the ability to delete genes such as angiotensinogen in CRH producing neurons...
  8. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ-VILLALOBOS; Fiscal Year: 2013
    ..Previous studies by the applicant demonstrate that the kidneys from Ang II-infused mice display an augmented angiotensinogen expression and persistence of renin and angiotensin-converting enzyme (ACE) activities that suggest the ..
  9. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Angiotensinogen (Ao) and other components of the local cardiac renin-angiotensin system (RAS) are upregulated in the hemodynamically overloaded heart...
  10. SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSION
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..b>Angiotensinogen (AGT), the initiating substrate of the system has been genetically linked to hypertension...
  11. GENETICS OF HYPERTENSION
    Ashok Kumar; Fiscal Year: 2013
    ..b>Angiotensinogen (AGT) gene locus is associated with human essential hypertension and its expression is increased by ..
  12. Multiphoton imaging of the juxtaglomerular apparatus
    Janos Peti-Peterdi; Fiscal Year: 2013
    ..research is the discovery of the (pro)renin receptor [(P)RR] challenging the existing simplistic RAS model (angiotensinogen, renin, converting enzyme, angiotensin (Ang) peptides and receptors)...
  13. Mitigation of Radiation Pneumonitis and Fibrosis
    ERIC PHIN COHEN; Fiscal Year: 2013
    ..2. To test the mechanism of mitigation of radiation lung injury by enalapril. a. Angiotensinogen, plasma renin activity, and angiotensin II will be measured as renin-angiotensin system markers in all ..
  14. Genetic Epidemiology of Treatment Resistant Hypertension in African Americans
    CHRISTOPHER O apos BRIAN PHILLIPS; Fiscal Year: 2013
    ..augmentation index [Aix]) compared with age/sex matched controls: ii) Allele frequencies for gain of function angiotensinogen (AGT) variants and AGT levels are significantly higher: iii) levels of pro-inflammatory cytokines, biomarker ..
  15. Transcriptional Regulation of Angiotensinogen Gene
    Ashok Kumar; Fiscal Year: 2013
    ..Previous studies have suggested that: (a) angiotensinogen (AGT) gene locus is associated with human essential hypertension, (b) variant -6A of the AGT gene is ..
  16. Role of Redox-Mediated Activation of NFkappaB and AP-1 in Neurogenic Hypertension
    Robin L Davisson; Fiscal Year: 2010
    ..cardiovascular nuclei of mice with Ang-ll slow-pressor, renovascular (2K1C) and life-long (human renin/human angiotensinogen) hypertension;Aim 2) Dissect the role of superoxide and H2O2 in Ang-ll-stimulated induction of NFkappaB and ..
  17. Placental Insufficiency in Transgenic Mouse Model of Preeclampsia and IUGR
    TERRY KNUD MORGAN; Fiscal Year: 2013
    ..To test this hypothesis, we validated a genetically engineered mouse model that simulates a common human angiotensinogen (AGT) variant that is associated with preeclampsia and IUGR...
  18. Angiotensin: A Link Between Obesity and Hypertension
    Lisa A Cassis; Fiscal Year: 2012
    ..b>Angiotensinogen (AGT), angiotensin type 1a receptors (AT1aR), and ACE2 are three components of the RAS that were regulated ..
  19. Receptor-mediated actions of renin in kidney fibrosis
    Yufeng Huang; Fiscal Year: 2012
    ..The specific hypothesis is that renin, in addition to its role to convert angiotensinogen to Ang I, has novel receptor- mediated actions that could play a role in renal fibrosis...
  20. Uterine Vascular Remodeling during Pregnancy
    James K Pru; Fiscal Year: 2013
    ..established that renin, an enzyme that generates active hemodynamic peptides through proteolytic cleavage of angiotensinogen, is up-regulated in the endometrium during early gestation...
  21. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ VILLALOBOS; Fiscal Year: 2010
    ..that chronic Ang II infusions in mice cause increases in blood pressure that are associated with augmented angiotensinogen expression and the persistence of renin activity in the kidneys as well as high intrarenal Ang II content...
  22. Central Cardiovascular Regulation and Proangiotensin-12
    Hreday N Sapru; Fiscal Year: 2013
    ..The significance of the proposed studies is high considering that over 61 million Americans suffer from some type of cardiovascular disease which is the leading cause of death in this country. ..
  23. Potential of Urinary AGT as a Novel Biomarker for Intrarenal RAS Activity in T1DM
    LUIS GABRIEL NAVAR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Angiotensinogen (AGT) is the only known substrate for renin, which is the rate-limiting enzyme of the renin-angiotensin system (RAS)...
  24. Sources and effects of angiotensin peptides in atherosclerosis
    Alan Daugherty; Fiscal Year: 2012
    ..application, for which we have now developed the mice that were requested in the previous reviews: floxed angiotensinogen and AT1a receptors. Therefore, all the critical reagents to the proposed studies are now available...
  25. GENETICS OF BLOOD PRESSURE CONTROL IN MEXICAN AMERICANS
    Larry Atwood; Fiscal Year: 2000
    ..genetic methods will be used to identify and characterize genes that affect plasma or serum levels of angiotensinogen (AGT), tissue kallikrein, and angiotensin converting enzyme (ACE) in 40 families comprising approximately ..
  26. RENIN-ANGIOTENSIN AND GROWTH IN URETERAL OBSTRUCTION
    ROBERT CHEVALIER; Fiscal Year: 1991
    ..Renin and angiotensinogen messenger RNA (mRNA) will be measured by complementary DNA (cDNA) probe, and renin release by individual ..
  27. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..Preliminary data suggest that Stx increases angiotensinogen and angiotensin converting enzyme (ACE) generation in PTCs, which are exquisitely sensitive to Stx 2...
  28. ACE Inhibition and Novel Cardiovascular Risk Factors
    Marco Pahor; Fiscal Year: 2004
    ..But, clinical trial evidence on these effects is limited. In addition, polymorphisms of the ACE, angiotensinogen, PAI-1 and IL-6 genes may modify the therapeutic response to ACE inhibitors...
  29. CELLULAR MECHANISMS FOR ANGIOTENSIN RESPONSES IN BRAIN
    ELISABETH TALLANT; Fiscal Year: 1999
    ..C and the release of prostacyclin; 3) Ang II differentially regulates expression of the mRNA for angiotensinogen (Aogen) in region-specific astrocytes, which may be regulated by a nuclear Ang II receptor that responds to ..
  30. TRANSGENIC IN HYPERTENSION--RAS RIBOZYNE INHIBITION
    John Mullins; Fiscal Year: 1992
    ..We plan to work with the two key genes of the renin angiotensin system (RAS), renin and angiotensinogen, which complement each other with respect to already available materials, functional analysis in transgenic ..
  31. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 2000
    ..the hypothesis, the investigator will address four Specific Aims: 1) to determine the relationship between angiotensinogen (AGT) genotype and hypertension in DM; 2) to test the hypothesis that variation in the pressor and ..
  32. GENETIC RISK FACTORS OF PREECLAMPSIA AMONG PERUVIAN WOME
    Michelle Williams; Fiscal Year: 2002
    ..tumor necrosis factor-alpha (TNF-alpha) gene, the methylenetetrahydrofolate reductase (MTHFR) gene, and the angiotensinogen (AGT) gene will also be assessed...
  33. ANGIOTENSIN II & HYPERTENSION
    Kevin Lynch; Fiscal Year: 1990
    The ability of the brain to synthesize angiotensinogen, angiotensin I and angiotensin II is now well established and it is widely accepted that angiotensin I and II produced by the brain itself can affect neuronal activity, autonomic ..
  34. ANGIOTENSIN II IN ENDOCRINE ORGANS
    Christian Deschepper; Fiscal Year: 1991
    ..Its generation in the blood involves a cascade in which the kidney enzyme renin cleaves angiotensinogen (secreted by the liver) into angiotensin I (AI). Converting enzyme then converts AI and AII...
  35. STABLE ISOTOPE LABELED PROTEINS AND DRUG DISPOSITION
    Fred Abramson; Fiscal Year: 2002
    ..The three protein disposition studies proposed are: (1) the angiotensinogen cascade and the effect of a protease inhibitor on that cascade; (2) the intracellular proteolysis of ..
  36. ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTS
    Bruce Psaty; Fiscal Year: 2004
    ..subunit (GB3) polymorphism, B2AR-16 polymorphism, the amiloride-sensitive epithelial sodium channel, and the angiotensinogen Met235Thr polymorphism...
  37. INTRARENAL ANGIOTENSINOGEN: LOCALIZATION & REGULATION
    Julie Ingelfinger; Fiscal Year: 1990
    ..The recent documentation of angiotensinogen mRNA in rat and mouse kidney provides strong evidence for the presence of an independent local RAS...
  38. HORMONAL REGULATION OF ANGIOTENSINOGEN GENE
    David Feldman; Fiscal Year: 1990
    ..We have focused on angiotensinogen (angen), important in the circulating renin angiotensin system, but also synthesized in extra-hepatic tissues...
  39. ANGIOTENSINOGEN VARIANTS AND ADVERSE PREGNANCY OUTCOMES
    Kenneth Ward; Fiscal Year: 2002
    ..Molecular variants of the angiotensinogen gene, which increase angiotensinogen expression in certain local systems, predispose women to develop ..
  40. NEURAL AND HUMORAL CONTROL OF ENDOCRINE FUNCTION
    Ian Reid; Fiscal Year: 1992
    ..II, with particular emphasis on hypothalamic control of renin secretion and neuroendocrine control of angiotensinogen secretion. The second project (P.I.: I.A...
  41. The Angiotensinogen Gene and Human Hypertension
    Lynn Jorde; Fiscal Year: 2006
    ..Many, but not all, studies have shown that variants of the angiotensinogen gene (AGT) affect the risk of hypertension, but association studies conducted to date have been compromised ..
  42. ROLE OF RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION
    Ashok Kumar; Fiscal Year: 1991
    ..most active pressor substance known, is synthesized by the proteolytic cleavage of its precursor molecule, angiotensinogen. Understanding the regulation of angiotensinogen synthesis is of vital importance as the renin - angiotensin ..
  43. PATHOGENESIS OF RADIATION-INDUCED KIDNEY INJURY
    Michael Robbins; Fiscal Year: 2004
    ..PAI-1), tissue inhibitor of metalloproteinases-2 (TIMP-2) matrix metalloproteinase-2 (MMP-2), TGF-B and angiotensinogen (AGT, precursor of Ang II)...
  44. Cell-specific Gene Targeting in Urologic Tissues
    JAMES CATTERALL; Fiscal Year: 2005
    ..transgene (1542 bp of the kidney androgen-regulated protein gene promoter fused to 9/7 kb of the human angiotensinogen gene) was expressed specifically in the proximal convoluted tubule (PCT) epithelial cells of the kidney and ..
  45. GENETIC DETERMINANTS OF HIGH BLOOD PRESSURE
    Alan Weder; Fiscal Year: 1999
    ..elements of the renin-angiotensin system (plasma renin and angiotensin-converting enzyme activity and serum angiotensinogen concentration)...
  46. ADIPOSE ANGIOTENSIONOGEN-ANGIOTENSIN SYSTEM
    Lisa Cassis; Fiscal Year: 1993
    b>Angiotensinogen is the only known precursor to the angiotensin peptides, which are important regulators in the control of blood pressure...
  47. NEUROHORMONAL CONTROL OF SALT APPETITE & BLOOD PRESSURE
    BRANDON YONGUE; Fiscal Year: 1992
    The proposed experiments will investigate the relationship of brain aldosterone binding angiotensinogen gene expression to control of a model motivated behavior (salt consumption) and a regulated physiological process (the circulation)...
  48. ANGIOTENSIN II INDUCTION OF PDGF SMOOTH MUSCLE CELLS
    Allen Naftilan; Fiscal Year: 1993
    ..Recently, angiotensinogen mRNA, the precursor for angiotensin (ang) II, has been localized in the blood vessel wall...
  49. OXIDATIVE STRESS AND DIABETIC CARDIOMYOPATHY
    Piero Anversa; Fiscal Year: 2003
    ..and secretion of Ang II Hyperglycemia-mediated enzymatic glycosylation of p53 may enhance transcription of angiotensinogen (Aogen) and AT1 receptor; Aogen is the limiting factor in the generation of Ang II and the AT1 effector ..
  50. PROPOSED INTRAOCULAR RENIN-ANGIOTENSIN SYSTEM
    INGOLF WALLOW; Fiscal Year: 1992
    ..Monoclonal or affinity-purified antibodies are available against five major components of the RAS: angiotensinogen, prorenin, renin, angiotensin-converting enzyme, and angiotensin II...
  51. Fetal origins of adult hypertension in microswine
    Susan Bagby; Fiscal Year: 2007
    ..in vivo ECV excess; 1B) MPR leads to intrarenal AnglI excess or activates AnglI-generating elements: renin, angiotensinogen (Aogn), AnglI Converting Enzyme (ACE); and 1C) MPR induces increased renal vascular contractile reactivity to ..
  52. NEUROENDOCRINOLOGY OF SALT APPETITE AND BLOOD PRESSURE
    BRANDON YONGUE; Fiscal Year: 1993
    ..training and research, the Candidate will investigate the relationship of brain aldosterone binding and brain angiotensinogen gene expression to control of a model motivated behavior (salt consumption) and a regulated physiological ..
  53. Intrarenal Augmentation of Angiotensinogen by Ang II
    Hiroyuki Kobori; Fiscal Year: 2010
    Angiotensin ll-infused rats exhibit increases in renal angiotensinogen (AGT) mRNA and protein, and this may be one mechanism by which low levels of circulating angiotensin II induce progressive hypertension...
  54. ROLE OF ANGIOTENSINOGEN IN HYPERTENSION AND STROKE
    Morton Printz; Fiscal Year: 1980
    ..factor which occurs with a very high frequency in hypertensive situations is an elevation of plasma levels of angiotensinogen. Angiotensinogen, molecular weight of 57,700, is the precursor protein of angiotensin II, molecular weight of ..
  55. RADIOIMMUNOASSAY OF ANGIOTENSINOGEN
    J Wilkinson; Fiscal Year: 1980
    ..A penultimate moiety will be selectively cleaved by chemical means from angiotensinogen and used as an antigen...
  56. FOREFRONTS IN NEPHROLOGY SYMPOSIUM--GENE THERAPY
    Paul Klotman; Fiscal Year: 2000
    ..The evidence from angiotensinogen knock-outs and quantitative "knock-in" experiments has provided proof of concept and molecular evidence that ..
  57. AGING AND HYPERTENSION--GENDER, GENES AND RISK
    Naomi Fisher; Fiscal Year: 2002
    ..to cause human hypertension, one of the very few for which linkage has been documented is that coding for angiotensinogen (AGT), a key element of the renin-angiotensin system - yet linkage has been convincingly shown only in males...
  58. ROLE OF ENHANCERS REGULATING RENIN GENE EXPRESSION
    CURT SIGMUND; Fiscal Year: 2004
    ..The PI anticipates that the experiments proposed in these aims should provide, for the first time, important information on the factors regulating renin expression and their relevance in in vivo setting. ..
  59. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  60. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  61. Significance of Genetic Variation in NOS3 and SOD3 Genes
    CURT SIGMUND; Fiscal Year: 2007
    ..These aims will allow us to assess the physiological importance of allelic variation in six genes implicated as risk factors in the pathogenesis of human essential hypertension or atherosclerosis. ..
  62. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..will cross the transgenic mice with null-Aogen mice to determine whether intracellular expression of Aogen (angiotensinogen) and subsequent intracellular generation of All can compensate for an absence of extracellular All and, thus, ..
  63. Renal Function Derangements in Hypertension
    LUIS GABRIEL NAVAR; Fiscal Year: 2010
    ..and interstitial Ang II, AT1 receptor mediated uptake of Ang II into endosomes and augmentation of intrarenal angiotensinogen (AGT) and tubular renin mRNA and protein via AT1 receptor mechanisms...